locus-tag	class	description
IR188_RS00005	COG2186	Transcriptional regulator
IR188_RS00010	COG0477	Major facilitator Superfamily
IR188_RS00015	COG1609	Transcriptional regulator
IR188_RS00020	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IR188_RS00025	COG1879	ABC-type sugar transport system periplasmic component
IR188_RS00030	COG1172	Belongs to the binding-protein-dependent transport system permease family
IR188_RS00035	COG1129	ABC transporter
IR188_RS00040	COG1869	D-ribose catabolic process
IR188_RS00045	COG3397	chitin binding
IR188_RS00055	COG2425	protein containing a von Willebrand factor type A (vWA) domain
IR188_RS00060	COG2502	aspartate--ammonia ligase
IR188_RS00065	COG1522	sequence-specific DNA binding
IR188_RS00070	COG0716	FMN binding
IR188_RS00075	COG0445	tRNA wobble uridine modification
IR188_RS00080	COG0357	Ribosomal RNA small subunit methyltransferase G
IR188_RS00085	COG3312	ion transport
IR188_RS00090	COG0356	it plays a direct role in the translocation of protons across the membrane
IR188_RS00100	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IR188_RS00105	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IR188_RS00110	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
IR188_RS00115	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IR188_RS00120	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IR188_RS00125	COG0355	proton-transporting ATP synthase activity, rotational mechanism
IR188_RS00130	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IR188_RS00135	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IR188_RS00210	COG0840	transmembrane signaling receptor activity
IR188_RS00215	COG0840	transmembrane signaling receptor activity
IR188_RS00230	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IR188_RS00235	COG0076	glutamate decarboxylase activity
IR188_RS00240	COG0531	amino acid
IR188_RS00245	COG2066	Belongs to the glutaminase family
IR188_RS00250	COG0531	amino acid
IR188_RS00265	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IR188_RS00285	COG0594	ribonuclease P activity
IR188_RS00290	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
IR188_RS00295	COG0706	membrane insertase activity
IR188_RS00300	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
IR188_RS00305	COG0697	spore germination
IR188_RS00345	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
IR188_RS00355	COG0437	4 iron, 4 sulfur cluster binding
IR188_RS00360	COG2864	formate dehydrogenase
IR188_RS00365	COG3058	Necessary for formate dehydrogenase activity
IR188_RS00370	COG1921	L-seryl-tRNASec selenium transferase activity
IR188_RS00375	COG3276	selenocysteine insertion sequence binding
IR188_RS00420	COG1275	C4-dicarboxylate transporter malic acid transport protein
IR188_RS00425	COG2233	PERMEase
IR188_RS00440	COG1561	YicC-like family, N-terminal region
IR188_RS00445	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
IR188_RS00450	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
IR188_RS00455	COG1309	transcriptional regulator
IR188_RS00460	COG0756	dUTP diphosphatase activity
IR188_RS00465	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IR188_RS00470	COG2003	Belongs to the UPF0758 family
IR188_RS00475	COG0227	Belongs to the bacterial ribosomal protein bL28 family
IR188_RS00480	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IR188_RS00485	COG0463	Glycosyl transferase, family 2
IR188_RS00495	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IR188_RS00500	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IR188_RS00510	COG1519	Transferase
IR188_RS00515	COG0859	PFAM glycosyl transferase family 9
IR188_RS00535	COG0859	PFAM glycosyl transferase family 9
IR188_RS00545	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IR188_RS00555	COG2861	carbohydrate metabolic process
IR188_RS00560	COG4942	peptidase
IR188_RS00565	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IR188_RS00570	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
IR188_RS00580	COG1045	serine acetyltransferase
IR188_RS00585	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
IR188_RS00590	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IR188_RS00615	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
IR188_RS00625	COG0438	transferase activity, transferring glycosyl groups
IR188_RS00630	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
IR188_RS00635	COG4750	Nucleotidyl transferase
IR188_RS00650	COG2205	protein histidine kinase activity
IR188_RS00655	COG0745	RESPONSE REGULATOR receiver
IR188_RS00670	COG0205	6-phosphofructokinase activity
IR188_RS00675	COG0149	triose-phosphate isomerase activity
IR188_RS00685	COG3152	Membrane
IR188_RS00695	COG2814	Major facilitator Superfamily
IR188_RS00700	COG0584	glycerophosphoryl diester phosphodiesterase
IR188_RS00705	COG2271	Major facilitator Superfamily
IR188_RS00710	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IR188_RS00720	COG3074	FtsZ-dependent cytokinesis
IR188_RS00725	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IR188_RS00730	COG1575	Belongs to the MenA family. Type 1 subfamily
IR188_RS00735	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
IR188_RS00740	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
IR188_RS00745	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IR188_RS00750	COG1609	Transcriptional regulator
IR188_RS00755	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IR188_RS00770	COG0626	cystathionine gamma-synthase activity
IR188_RS00775	COG0527	aspartate kinase activity
IR188_RS00775	COG0460	homoserine dehydrogenase
IR188_RS00780	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
IR188_RS00800	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IR188_RS00805	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
IR188_RS00810	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IR188_RS00815	COG0137	argininosuccinate synthase activity
IR188_RS00820	COG0165	Argininosuccinate lyase
IR188_RS00830	COG0583	DNA-binding transcription factor activity
IR188_RS00835	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IR188_RS00865	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IR188_RS00885	COG1217	gtp-binding protein TYPA
IR188_RS00890	COG1011	Hydrolase
IR188_RS00900	COG0456	acetyltransferase
IR188_RS00905	COG2982	Protein involved in outer membrane biogenesis
IR188_RS00910	COG2233	PERMEase
IR188_RS00915	COG0786	glutamate:sodium symporter activity
IR188_RS00920	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IR188_RS00925	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IR188_RS00930	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IR188_RS00935	COG1758	RNA polymerase activity
IR188_RS00945	COG2860	membrane
IR188_RS00950	COG0823	Involved in the tonB-independent uptake of proteins
IR188_RS00955	COG5645	(Lipo)protein
IR188_RS00960	COG2818	Glycosylase
IR188_RS00975	COG3210	domain, Protein
IR188_RS00990	COG0747	negative chemotaxis
IR188_RS00995	COG0601	transmembrane transport
IR188_RS01000	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IR188_RS01005	COG0444	Belongs to the ABC transporter superfamily
IR188_RS01010	COG4608	Belongs to the ABC transporter superfamily
IR188_RS01015	COG2199	diguanylate cyclase activity
IR188_RS01015	COG2200	EAL domain
IR188_RS01030	COG1942	4-Oxalocrotonate Tautomerase
IR188_RS01035	COG1295	ribonuclease BN
IR188_RS01045	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
IR188_RS01050	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IR188_RS01070	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
IR188_RS01080	COG0746	molybdenum cofactor guanylyltransferase activity
IR188_RS01085	COG3084	Protein conserved in bacteria
IR188_RS01090	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
IR188_RS01095	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IR188_RS01100	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IR188_RS01100	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IR188_RS01105	COG0242	peptide deformylase activity
IR188_RS01110	COG0218	Necessary for normal cell division and for the maintenance of normal septation
IR188_RS01115	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IR188_RS01125	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IR188_RS01130	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IR188_RS01135	COG1765	OsmC-like protein
IR188_RS01140	COG3954	Phosphoribulokinase
IR188_RS01145	COG3089	Belongs to the UPF0270 family
IR188_RS01150	COG0429	hydrolase of the alpha beta-hydrolase fold
IR188_RS01160	COG1263	PTS System
IR188_RS01160	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IR188_RS01165	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
IR188_RS01175	COG0488	(ABC) transporter
IR188_RS01180	COG2249	NAD(P)H dehydrogenase (quinone) activity
IR188_RS01190	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
IR188_RS01195	COG1047	Peptidyl-prolyl cis-trans
IR188_RS01200	COG2900	Belongs to the SlyX family
IR188_RS01205	COG0545	Peptidyl-prolyl cis-trans isomerase
IR188_RS01210	COG2964	Protein conserved in bacteria
IR188_RS01230	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IR188_RS01235	COG0049	tRNA binding
IR188_RS01240	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IR188_RS01255	COG0250	Participates in transcription elongation, termination and antitermination
IR188_RS01260	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IR188_RS01265	COG0081	regulation of translation
IR188_RS01270	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IR188_RS01280	COG0085	RNA polymerase activity
IR188_RS01285	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IR188_RS01290	COG0726	polysaccharide deacetylase
IR188_RS01300	COG0626	cystathionine gamma-synthase activity
IR188_RS01305	COG1115	amino acid carrier protein
IR188_RS01310	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IR188_RS01315	COG2022	thiamine diphosphate biosynthetic process
IR188_RS01320	COG2104	thiamine diphosphate biosynthetic process
IR188_RS01325	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IR188_RS01330	COG0352	thiamine-phosphate diphosphorylase activity
IR188_RS01335	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
IR188_RS01340	COG0840	transmembrane signaling receptor activity
IR188_RS01350	COG3842	ATPase activity
IR188_RS01375	COG2816	NAD+ diphosphatase activity
IR188_RS01380	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
IR188_RS01385	COG1515	deoxyribonuclease V activity
IR188_RS01390	COG3068	Protein conserved in bacteria
IR188_RS01405	COG0151	Belongs to the GarS family
IR188_RS01410	COG0138	bifunctional purine biosynthesis protein purh
IR188_RS01440	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
IR188_RS01445	COG0800	Aldolase
IR188_RS01450	COG0129	dihydroxy-acid dehydratase activity
IR188_RS01455	COG0646	methionine synthase
IR188_RS01455	COG1410	methionine synthase
IR188_RS01465	COG0527	aspartate kinase activity
IR188_RS01480	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
IR188_RS01485	COG2937	Belongs to the GPAT DAPAT family
IR188_RS01490	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
IR188_RS01495	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IR188_RS01500	COG0735	belongs to the Fur family
IR188_RS01505	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IR188_RS01510	COG1396	sequence-specific DNA binding
IR188_RS01540	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
IR188_RS01550	COG5532	Uncharacterized conserved protein (DUF2303)
IR188_RS01645	COG1403	HNH endonuclease
IR188_RS01685	COG3772	lysozyme
IR188_RS01725	COG0740	serine-type endopeptidase activity
IR188_RS01830	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IR188_RS01855	COG1448	Aminotransferase
IR188_RS01860	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IR188_RS01870	COG0629	single-stranded DNA binding
IR188_RS01875	COG2801	Transposase and inactivated derivatives
IR188_RS01890	COG0028	Belongs to the TPP enzyme family
IR188_RS01895	COG0440	acetolactate synthase activity
IR188_RS01915	COG2252	PERMEase
IR188_RS01920	COG0025	NhaP-type Na H and K H
IR188_RS01930	COG0583	DNA-binding transcription factor activity
IR188_RS01935	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
IR188_RS01940	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
IR188_RS01945	COG1690	Belongs to the RtcB family
IR188_RS01955	COG2365	Tyrosine phosphatase family
IR188_RS01960	COG0586	Pfam SNARE associated Golgi protein
IR188_RS01965	COG1322	Protein conserved in bacteria
IR188_RS01970	COG2226	methyltransferase
IR188_RS01980	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IR188_RS01985	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IR188_RS01990	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IR188_RS01995	COG0805	protein transport
IR188_RS02010	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
IR188_RS02020	COG0183	Belongs to the thiolase family
IR188_RS02030	COG0006	proline dipeptidase activity
IR188_RS02035	COG1739	Uncharacterized protein family UPF0029
IR188_RS02040	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IR188_RS02045	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
IR188_RS02080	COG1472	Belongs to the glycosyl hydrolase 3 family
IR188_RS02090	COG0583	DNA-binding transcription factor activity
IR188_RS02095	COG1124	(ABC) transporter
IR188_RS02135	COG2813	Specifically methylates the guanine in position
IR188_RS02140	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
IR188_RS02155	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
IR188_RS02165	COG4667	esterase of the alpha-beta hydrolase superfamily
IR188_RS02170	COG0084	hydrolase, TatD family'
IR188_RS02175	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IR188_RS02180	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
IR188_RS02185	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
IR188_RS02190	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
IR188_RS02200	COG0612	Peptidase, M16
IR188_RS02205	COG4178	(ABC) transporter
IR188_RS02210	COG4771	TonB-dependent receptor
IR188_RS02240	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IR188_RS02245	COG4172	Belongs to the ABC transporter superfamily
IR188_RS02255	COG0832	Belongs to the urease beta subunit family
IR188_RS02260	COG0804	urea catabolic process
IR188_RS02275	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
IR188_RS02285	COG4413	Urea transporter
IR188_RS02290	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IR188_RS02295	COG1289	transmembrane transporter activity
IR188_RS02300	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IR188_RS02305	COG3726	membrane protein affecting hemolysin expression
IR188_RS02310	COG0560	Phosphoserine phosphatase
IR188_RS02315	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
IR188_RS02325	COG0488	(ABC) transporter
IR188_RS02335	COG0741	lytic transglycosylase activity
IR188_RS02340	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
IR188_RS02355	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
IR188_RS02360	COG0406	alpha-ribazole phosphatase activity
IR188_RS02365	COG3708	Transcriptional regulator
IR188_RS02365	COG2207	Transcriptional regulator
IR188_RS02370	COG3045	CreA protein
IR188_RS02375	COG0745	RESPONSE REGULATOR receiver
IR188_RS02390	COG0083	homoserine kinase activity
IR188_RS02405	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IR188_RS02410	COG0521	Mo-molybdopterin cofactor biosynthetic process
IR188_RS02420	COG0443	Heat shock 70 kDa protein
IR188_RS02425	COG0484	heat shock protein binding
IR188_RS02435	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
IR188_RS02440	COG0583	DNA-binding transcription factor activity
IR188_RS02445	COG0268	Binds directly to 16S ribosomal RNA
IR188_RS02450	COG0196	riboflavin kinase activity
IR188_RS02455	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
IR188_RS02460	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
IR188_RS02465	COG1047	Peptidyl-prolyl cis-trans
IR188_RS02470	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
IR188_RS02480	COG0505	Belongs to the CarA family
IR188_RS02490	COG1293	RNA-binding protein homologous to eukaryotic snRNP
IR188_RS02490	COG5295	Hep Hag repeat protein
IR188_RS02500	COG1979	alcohol dehydrogenase
IR188_RS02505	COG0586	Pfam SNARE associated Golgi protein
IR188_RS02515	COG0848	biopolymer transport protein
IR188_RS02525	COG4991	sh3 domain protein
IR188_RS02530	COG3025	triphosphatase activity
IR188_RS02535	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
IR188_RS02540	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
IR188_RS02540	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
IR188_RS02550	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IR188_RS02555	COG3384	dioxygenase
IR188_RS02560	COG0754	glutathionylspermidine amidase activity
IR188_RS02575	COG0494	nUDIX hydrolase
IR188_RS02580	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
IR188_RS02585	COG3150	esterase
IR188_RS02600	COG0204	Acyl-transferase
IR188_RS02605	COG2132	Multicopper oxidase
IR188_RS02615	COG1280	lysine exporter protein (LysE YggA)
IR188_RS02625	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
IR188_RS02635	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IR188_RS02640	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IR188_RS02645	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IR188_RS02650	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
IR188_RS02655	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
IR188_RS02660	COG0564	pseudouridine synthase activity
IR188_RS02665	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IR188_RS02670	COG0417	DNA replication proofreading
IR188_RS02675	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
IR188_RS02680	COG1178	ABC-type Fe3 transport system permease component
IR188_RS02685	COG4143	(ABC) transporter
IR188_RS02690	COG0494	nUDIX hydrolase
IR188_RS02700	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IR188_RS02705	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
IR188_RS02715	COG4795	General secretion pathway protein
IR188_RS02730	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
IR188_RS02740	COG1074	ATP-dependent DNA helicase activity
IR188_RS02745	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IR188_RS02750	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IR188_RS02750	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
IR188_RS02755	COG0860	N-Acetylmuramoyl-L-alanine amidase
IR188_RS02775	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
IR188_RS02780	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
IR188_RS02785	COG2166	iron-sulfur cluster assembly
IR188_RS02790	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IR188_RS02795	COG0583	DNA-binding transcription factor activity
IR188_RS02800	COG2363	Small membrane protein
IR188_RS02815	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IR188_RS02820	COG1611	Belongs to the LOG family
IR188_RS02835	COG3098	single-species biofilm formation
IR188_RS02840	COG0564	pseudouridine synthase activity
IR188_RS02845	COG0716	FMN binding
IR188_RS02860	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
IR188_RS02875	COG0052	Belongs to the universal ribosomal protein uS2 family
IR188_RS02880	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IR188_RS02885	COG0528	UMP kinase activity
IR188_RS02890	COG0233	cytoplasmic translational termination
IR188_RS02900	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IR188_RS02905	COG0575	Belongs to the CDS family
IR188_RS02915	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IR188_RS02925	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IR188_RS02930	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IR188_RS02935	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IR188_RS02940	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IR188_RS02945	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
IR188_RS02955	COG0825	malonyl-CoA metabolic process
IR188_RS02960	COG0037	tRNA processing
IR188_RS02965	COG4568	rho-dependent transcription termination
IR188_RS02970	COG3015	lipoprotein NlpE involved in copper resistance
IR188_RS02975	COG0442	prolyl-tRNA aminoacylation
IR188_RS02980	COG1720	tRNA m6t6A37 methyltransferase activity
IR188_RS02990	COG1464	Belongs to the NlpA lipoprotein family
IR188_RS03000	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IR188_RS03005	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
IR188_RS03030	COG3021	interspecies interaction between organisms
IR188_RS03050	COG0602	queuosine metabolic process
IR188_RS03055	COG0720	synthase
IR188_RS03060	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
IR188_RS03070	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
IR188_RS03075	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
IR188_RS03080	COG0585	pseudouridine synthase activity
IR188_RS03090	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
IR188_RS03095	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IR188_RS03100	COG1388	LysM domain
IR188_RS03100	COG4942	peptidase
IR188_RS03110	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
IR188_RS03145	COG0471	metal ion transport
IR188_RS03175	COG1301	dicarboxylic acid transport
IR188_RS03180	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
IR188_RS03180	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
IR188_RS03190	COG0501	Belongs to the peptidase M48B family
IR188_RS03195	COG0583	DNA-binding transcription factor activity
IR188_RS03205	COG0588	phosphoglycerate mutase activity
IR188_RS03215	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
IR188_RS03220	COG1492	cobalamin metabolic process
IR188_RS03285	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
IR188_RS03305	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IR188_RS03305	COG1648	precorrin-2 dehydrogenase activity
IR188_RS03320	COG1648	precorrin-2 dehydrogenase activity
IR188_RS03320	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IR188_RS03325	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IR188_RS03335	COG4865	methylaspartate mutase activity
IR188_RS03340	COG3799	methylaspartate ammonia-lyase activity
IR188_RS03355	COG1301	dicarboxylic acid transport
IR188_RS03365	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IR188_RS03370	COG2271	Major facilitator Superfamily
IR188_RS03375	COG1082	Xylose isomerase domain protein TIM barrel
IR188_RS03380	COG2188	Transcriptional regulator
IR188_RS03390	COG4810	utilization protein
IR188_RS03395	COG4917	ethanolamine utilization protein
IR188_RS03405	COG4812	Cobalamin adenosyltransferase
IR188_RS03410	COG0280	phosphate acetyltransferase
IR188_RS03420	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
IR188_RS03430	COG4820	ethanolamine utilization protein (EutJ)
IR188_RS03445	COG4819	ethanolamine utilization protein
IR188_RS03450	COG4303	Ethanolamine ammonia lyase large subunit
IR188_RS03460	COG4816	utilization protein
IR188_RS03465	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
IR188_RS03470	COG4656	Part of a membrane complex involved in electron transport
IR188_RS03485	COG0252	asparaginase activity
IR188_RS03490	COG4206	TonB-dependent receptor
IR188_RS03520	COG2252	PERMEase
IR188_RS03525	COG0402	S-adenosylhomocysteine deaminase activity
IR188_RS03530	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IR188_RS03530	COG2080	2 iron, 2 sulfur cluster binding
IR188_RS03535	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
IR188_RS03540	COG0402	S-adenosylhomocysteine deaminase activity
IR188_RS03545	COG0493	'glutamate synthase
IR188_RS03545	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
IR188_RS03550	COG2068	MobA-Related Protein
IR188_RS03555	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IR188_RS03560	COG3608	succinylglutamate desuccinylase aspartoacylase
IR188_RS03560	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
IR188_RS03565	COG1914	H( )-stimulated, divalent metal cation uptake system
IR188_RS03575	COG0668	transmembrane transport
IR188_RS03600	COG0477	Major facilitator Superfamily
IR188_RS03610	COG0549	Belongs to the carbamate kinase family
IR188_RS03620	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IR188_RS03625	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IR188_RS03630	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IR188_RS03635	COG3829	transcription factor binding
IR188_RS03645	COG1733	regulation of RNA biosynthetic process
IR188_RS03650	COG2080	2 iron, 2 sulfur cluster binding
IR188_RS03655	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
IR188_RS03660	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IR188_RS03675	COG4566	intracellular signal transduction
IR188_RS03685	COG2962	Rard protein
IR188_RS03705	COG1966	Carbon starvation protein
IR188_RS03710	COG0523	cobalamin synthesis protein
IR188_RS03720	COG0534	Mate efflux family protein
IR188_RS03725	COG0673	inositol 2-dehydrogenase activity
IR188_RS03735	COG3033	Beta-eliminating lyase
IR188_RS03740	COG0814	amino acid
IR188_RS03745	COG5564	TIM-barrel signal transduction protein
IR188_RS03750	COG5441	Belongs to the UPF0261 family
IR188_RS03775	COG3842	ATPase activity
IR188_RS03785	COG1840	ABC-type Fe3 transport system, periplasmic component
IR188_RS03790	COG2271	Major facilitator Superfamily
IR188_RS03820	COG0288	reversible hydration of carbon dioxide
IR188_RS03825	COG1131	(ABC) transporter
IR188_RS03830	COG0842	Transport permease protein
IR188_RS03860	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
IR188_RS03865	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IR188_RS03885	COG1489	DNA binding
IR188_RS03890	COG1643	Atp-dependent helicase
IR188_RS03895	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IR188_RS03910	COG2864	formate dehydrogenase
IR188_RS03915	COG0437	4 iron, 4 sulfur cluster binding
IR188_RS03930	COG0243	molybdopterin cofactor binding
IR188_RS03935	COG0437	4 iron, 4 sulfur cluster binding
IR188_RS03945	COG3381	protein complex oligomerization
IR188_RS03955	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IR188_RS03960	COG0316	Belongs to the HesB IscA family
IR188_RS03980	COG0437	4 iron, 4 sulfur cluster binding
IR188_RS04000	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
IR188_RS04015	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IR188_RS04020	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IR188_RS04025	COG3956	TIGRFAM MazG family protein
IR188_RS04030	COG0504	CTP synthase activity
IR188_RS04035	COG0148	phosphopyruvate hydratase activity
IR188_RS04040	COG0471	metal ion transport
IR188_RS04045	COG0741	lytic transglycosylase activity
IR188_RS04045	COG1388	LysM domain
IR188_RS04050	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IR188_RS04055	COG2226	methyltransferase
IR188_RS04060	COG0328	RNA-DNA hybrid ribonuclease activity
IR188_RS04065	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IR188_RS04080	COG2233	PERMEase
IR188_RS04085	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IR188_RS04090	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IR188_RS04115	COG1358	cellular component organization or biogenesis
IR188_RS04175	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IR188_RS04185	COG1846	Transcriptional regulator
IR188_RS04190	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IR188_RS04205	COG1349	DNA-binding transcription factor activity
IR188_RS04210	COG0561	phosphatase activity
IR188_RS04215	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IR188_RS04225	COG1304	FMN binding
IR188_RS04230	COG1620	l-lactate permease
IR188_RS04265	COG2211	Major facilitator Superfamily
IR188_RS04280	COG1840	ABC-type Fe3 transport system, periplasmic component
IR188_RS04285	COG0395	ABC-type sugar transport system, permease component
IR188_RS04290	COG3842	ATPase activity
IR188_RS04300	COG0500	methyltransferase
IR188_RS04305	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IR188_RS04310	COG1737	Transcriptional regulator
IR188_RS04315	COG2731	YhcH YjgK YiaL family protein
IR188_RS04320	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IR188_RS04330	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
IR188_RS04335	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
IR188_RS04365	COG2375	cellular response to nickel ion
IR188_RS04365	COG1132	(ABC) transporter
IR188_RS04385	COG3433	isochorismatase activity
IR188_RS04385	COG2226	methyltransferase
IR188_RS04385	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IR188_RS04395	COG2814	Major facilitator Superfamily
IR188_RS04400	COG4771	TonB-dependent receptor
IR188_RS04405	COG0582	viral genome integration into host DNA
IR188_RS04415	COG0741	lytic transglycosylase activity
IR188_RS04420	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
IR188_RS04425	COG1194	a g-specific adenine glycosylase
IR188_RS04435	COG3171	Protein conserved in bacteria
IR188_RS04440	COG2066	Belongs to the glutaminase family
IR188_RS04450	COG4607	ABC-type enterochelin transport system periplasmic component
IR188_RS04455	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IR188_RS04460	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
IR188_RS04465	COG0762	integral membrane protein
IR188_RS04470	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
IR188_RS04475	COG2805	Type II/IV secretion system protein
IR188_RS04480	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IR188_RS04485	COG1678	Uncharacterized ACR, COG1678
IR188_RS04490	COG0189	ligase activity
IR188_RS04495	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IR188_RS04515	COG0583	DNA-binding transcription factor activity
IR188_RS04520	COG0583	DNA-binding transcription factor activity
IR188_RS04530	COG1902	pentaerythritol trinitrate reductase activity
IR188_RS04540	COG1960	acyl-CoA dehydrogenase activity
IR188_RS04550	COG0121	glutamine amidotransferase
IR188_RS04555	COG3034	peptidoglycan biosynthetic process
IR188_RS04560	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
IR188_RS04565	COG1805	sodium ion transport
IR188_RS04570	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
IR188_RS04575	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
IR188_RS04580	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
IR188_RS04585	COG2871	sodium ion transport
IR188_RS04590	COG1477	protein flavinylation
IR188_RS04595	COG2991	Protein conserved in bacteria
IR188_RS04610	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IR188_RS04615	COG2195	Cleaves the N-terminal amino acid of tripeptides
IR188_RS04620	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
IR188_RS04625	COG1073	alpha beta
IR188_RS04635	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
IR188_RS04640	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
IR188_RS04645	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IR188_RS04660	COG1546	Belongs to the CinA family
IR188_RS04665	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IR188_RS04670	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IR188_RS04675	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
IR188_RS04705	COG2918	glutathione biosynthetic process
IR188_RS04715	COG4536	flavin adenine dinucleotide binding
IR188_RS04720	COG4137	Cytochrome C assembly protein
IR188_RS04725	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IR188_RS04740	COG0336	Belongs to the RNA methyltransferase TrmD family
IR188_RS04745	COG0335	large ribosomal subunit rRNA binding
IR188_RS04750	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IR188_RS04755	COG0287	Prephenate dehydrogenase
IR188_RS04755	COG1605	Chorismate mutase
IR188_RS04765	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
IR188_RS04770	COG0077	Prephenate dehydratase
IR188_RS04770	COG1605	Chorismate mutase
IR188_RS04775	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
IR188_RS04780	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IR188_RS04795	COG0542	response to heat
IR188_RS04835	COG5544	Lipoprotein
IR188_RS04840	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IR188_RS04845	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IR188_RS04845	COG0045	succinate-CoA ligase (ADP-forming) activity
IR188_RS04845	COG1042	CoA-binding domain protein
IR188_RS04850	COG3148	PFAM DTW domain containing protein
IR188_RS04855	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IR188_RS04860	COG2814	Major facilitator Superfamily
IR188_RS04865	COG1566	PFAM secretion protein HlyD family protein
IR188_RS04870	COG1846	Transcriptional regulator
IR188_RS04875	COG2814	Major facilitator Superfamily
IR188_RS04880	COG2113	Glycine betaine
IR188_RS04885	COG4176	ABC-type proline glycine betaine transport system permease component
IR188_RS04890	COG4175	Glycine betaine
IR188_RS04910	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
IR188_RS04915	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
IR188_RS04920	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IR188_RS04925	COG1278	Cold shock
IR188_RS04930	COG0697	spore germination
IR188_RS04935	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
IR188_RS04945	COG2921	Belongs to the UPF0250 family
IR188_RS04950	COG1686	Belongs to the peptidase S11 family
IR188_RS04955	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IR188_RS04960	COG0772	Belongs to the SEDS family
IR188_RS04965	COG0768	penicillin binding
IR188_RS04970	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
IR188_RS04975	COG0799	negative regulation of ribosome biogenesis
IR188_RS04985	COG1733	regulation of RNA biosynthetic process
IR188_RS04990	COG4221	oxidoreductase activity
IR188_RS05000	COG1466	dna polymerase III delta subunit
IR188_RS05005	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
IR188_RS05010	COG0495	leucyl-tRNA aminoacylation
IR188_RS05015	COG1126	abc transporter atp-binding protein
IR188_RS05020	COG0765	amino acid transport
IR188_RS05025	COG0765	amino acid transport
IR188_RS05040	COG4232	protein-disulfide reductase activity
IR188_RS05050	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IR188_RS05055	COG0815	Transfers the fatty acyl group on membrane lipoproteins
IR188_RS05065	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
IR188_RS05070	COG1702	phosphate starvation-inducible protein PhoH
IR188_RS05075	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IR188_RS05080	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IR188_RS05120	COG1940	carbohydrate kinase activity
IR188_RS05120	COG1846	Transcriptional regulator
IR188_RS05125	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IR188_RS05130	COG0363	glucosamine-6-phosphate deaminase activity
IR188_RS05135	COG2190	(PTS) system
IR188_RS05135	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IR188_RS05135	COG1263	PTS System
IR188_RS05140	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IR188_RS05145	COG0735	belongs to the Fur family
IR188_RS05150	COG0716	FMN binding
IR188_RS05170	COG0596	Alpha beta hydrolase
IR188_RS05175	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
IR188_RS05180	COG0033	Phosphoglucomutase
IR188_RS05195	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
IR188_RS05200	COG2814	Major facilitator Superfamily
IR188_RS05210	COG0372	Belongs to the citrate synthase family
IR188_RS05220	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
IR188_RS05225	COG1053	succinate dehydrogenase
IR188_RS05235	COG0567	Dehydrogenase, E1 component
IR188_RS05240	COG0508	dehydrogenase complex catalyzes the overall conversion of
IR188_RS05245	COG0045	succinate-CoA ligase (ADP-forming) activity
IR188_RS05250	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
IR188_RS05255	COG1271	oxidase subunit
IR188_RS05260	COG1294	oxidase, subunit
IR188_RS05265	COG4890	Cyd operon protein YbgT
IR188_RS05270	COG3790	cyd operon protein YbgE
IR188_RS05275	COG0583	DNA-binding transcription factor activity
IR188_RS05280	COG2814	Major facilitator Superfamily
IR188_RS05290	COG0824	Thioesterase
IR188_RS05295	COG0811	peptide transport
IR188_RS05300	COG0848	biopolymer transport protein
IR188_RS05305	COG3064	Membrane
IR188_RS05305	COG3064	Membrane
IR188_RS05310	COG0823	Involved in the tonB-independent uptake of proteins
IR188_RS05315	COG2885	chlorophyll binding
IR188_RS05320	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
IR188_RS05350	COG2354	Protein conserved in bacteria
IR188_RS05355	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IR188_RS05360	COG0588	phosphoglycerate mutase activity
IR188_RS05370	COG1119	ATPase activity
IR188_RS05380	COG3585	molybdate ion transport
IR188_RS05380	COG2005	Transcriptional regulator
IR188_RS05395	COG0725	ABC transporter, periplasmic molybdate-binding protein
IR188_RS05400	COG4149	molybdate abc transporter
IR188_RS05405	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
IR188_RS05415	COG0561	phosphatase activity
IR188_RS05420	COG2706	6-phosphogluconolactonase activity
IR188_RS05430	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IR188_RS05440	COG2226	methyltransferase
IR188_RS05445	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
IR188_RS05455	COG0556	nucleotide-excision repair
IR188_RS05470	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IR188_RS05480	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
IR188_RS05485	COG0314	molybdopterin synthase activity
IR188_RS05490	COG0670	Belongs to the BI1 family
IR188_RS05495	COG0842	Transport permease protein
IR188_RS05500	COG0842	Transport permease protein
IR188_RS05505	COG1131	(ABC) transporter
IR188_RS05515	COG1309	transcriptional regulator
IR188_RS05520	COG0513	Belongs to the DEAD box helicase family
IR188_RS05525	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IR188_RS05530	COG2261	transglycosylase associated protein
IR188_RS05535	COG2897	thiosulfate sulfurtransferase activity
IR188_RS05560	COG5006	permease, DMT superfamily
IR188_RS05580	COG0531	amino acid
IR188_RS05585	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
IR188_RS05590	COG0402	S-adenosylhomocysteine deaminase activity
IR188_RS05595	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IR188_RS05600	COG0303	'Molybdopterin
IR188_RS05605	COG0477	Major facilitator Superfamily
IR188_RS05615	COG0302	gtp cyclohydrolase
IR188_RS05620	COG2311	Membrane
IR188_RS05625	COG2949	membrane
IR188_RS05630	COG0281	malic enzyme
IR188_RS05640	COG1346	cytolysis
IR188_RS05645	COG1380	Effector of murein hydrolase LrgA
IR188_RS05650	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IR188_RS05650	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IR188_RS05655	COG0489	protein tyrosine kinase activity
IR188_RS05660	COG0572	uridine kinase
IR188_RS05665	COG0717	Belongs to the dCTP deaminase family
IR188_RS05670	COG2982	Protein involved in outer membrane biogenesis
IR188_RS05675	COG3069	C4-dicarboxylate transmembrane transporter activity
IR188_RS05680	COG0307	riboflavin synthase, alpha
IR188_RS05695	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
IR188_RS05710	COG0025	NhaP-type Na H and K H
IR188_RS05720	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IR188_RS05725	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IR188_RS05725	COG0140	phosphoribosyl-ATP diphosphatase activity
IR188_RS05740	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
IR188_RS05745	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
IR188_RS05745	COG0131	Imidazoleglycerol-phosphate dehydratase
IR188_RS05750	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IR188_RS05750	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
IR188_RS05755	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
IR188_RS05760	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
IR188_RS05770	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IR188_RS05775	COG0625	glutathione transferase activity
IR188_RS05780	COG1686	Belongs to the peptidase S11 family
IR188_RS05790	COG1760	l-serine dehydratase
IR188_RS05795	COG0814	amino acid
IR188_RS05800	COG0814	amino acid
IR188_RS05805	COG0671	phosphoesterase, PA-phosphatase related
IR188_RS05825	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IR188_RS05830	COG4160	amino acid transport
IR188_RS05835	COG4215	(ABC) transporter
IR188_RS05840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IR188_RS05845	COG1126	abc transporter atp-binding protein
IR188_RS05850	COG0702	epimerase
IR188_RS05855	COG2431	L-lysine efflux transmembrane transporter activity
IR188_RS05860	COG3593	DNA synthesis involved in DNA repair
IR188_RS05865	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IR188_RS05870	COG1136	(ABC) transporter
IR188_RS05870	COG0577	efflux transmembrane transporter activity
IR188_RS05875	COG1278	Cold shock
IR188_RS05880	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
IR188_RS05885	COG0542	response to heat
IR188_RS05890	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
IR188_RS05895	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
IR188_RS05900	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
IR188_RS05910	COG0492	ferredoxin-NADP+ reductase activity
IR188_RS05915	COG1522	sequence-specific DNA binding
IR188_RS05920	COG3107	peptidoglycan biosynthetic process
IR188_RS05920	COG1674	ftsk spoiiie
IR188_RS05925	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
IR188_RS05930	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IR188_RS05935	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
IR188_RS05945	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
IR188_RS05950	COG1882	Formate acetyltransferase
IR188_RS05955	COG2116	formate transmembrane transporter activity
IR188_RS05960	COG1944	ATP diphosphatase activity
IR188_RS05965	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
IR188_RS05970	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IR188_RS05975	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
IR188_RS05980	COG0539	negative regulation of cytoplasmic translation
IR188_RS05990	COG0658	competence protein
IR188_RS05990	COG2333	competence protein COMEC
IR188_RS06000	COG1663	tetraacyldisaccharide 4'-kinase activity
IR188_RS06005	COG1278	Cold shock
IR188_RS06010	COG2835	tetraacyldisaccharide 4'-kinase activity
IR188_RS06015	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
IR188_RS06020	COG1434	Gram-negative-bacterium-type cell wall biogenesis
IR188_RS06025	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IR188_RS06030	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
IR188_RS06035	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
IR188_RS06040	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
IR188_RS06045	COG1335	isochorismatase
IR188_RS06055	COG2989	Protein conserved in bacteria
IR188_RS06060	COG3108	Peptidase M15
IR188_RS06065	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IR188_RS06070	COG1448	Aminotransferase
IR188_RS06085	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
IR188_RS06090	COG0308	aminopeptidase N
IR188_RS06095	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
IR188_RS06100	COG0167	dihydroorotate dehydrogenase activity
IR188_RS06110	COG0633	Ferredoxin
IR188_RS06110	COG3217	Mosc domain protein beta barrel domain protein
IR188_RS06115	COG0116	Belongs to the methyltransferase superfamily
IR188_RS06115	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IR188_RS06120	COG0488	(ABC) transporter
IR188_RS06125	COG2995	paraquat-inducible protein a
IR188_RS06130	COG3008	intermembrane lipid transfer
IR188_RS06130	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IR188_RS06140	COG3130	regulation of translation
IR188_RS06150	COG1067	ATP-dependent peptidase activity
IR188_RS06155	COG3120	sequence-specific DNA binding
IR188_RS06175	COG1289	transmembrane transporter activity
IR188_RS06180	COG0210	DNA helicase
IR188_RS06185	COG1803	Methylglyoxal synthase
IR188_RS06190	COG1832	CoA-binding protein
IR188_RS06195	COG3785	DNA binding
IR188_RS06200	COG1254	Belongs to the acylphosphatase family
IR188_RS06205	COG2920	part of a sulfur-relay system
IR188_RS06220	COG3383	formate dehydrogenase (NAD+) activity
IR188_RS06225	COG2391	methyltransferase activity
IR188_RS06230	COG0425	Belongs to the sulfur carrier protein TusA family
IR188_RS06240	COG1811	Na channel or pump
IR188_RS06250	COG2388	GCN5-related N-acetyl-transferase
IR188_RS06260	COG3615	Tellurite resistance protein tehB
IR188_RS06285	COG3539	Fimbrial protein
IR188_RS06295	COG3708	Transcriptional regulator
IR188_RS06295	COG2207	Transcriptional regulator
IR188_RS06300	COG0840	transmembrane signaling receptor activity
IR188_RS06310	COG4221	oxidoreductase activity
IR188_RS06320	COG1982	Orn Lys Arg decarboxylase major
IR188_RS06330	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IR188_RS06335	COG0583	DNA-binding transcription factor activity
IR188_RS06340	COG0583	DNA-binding transcription factor activity
IR188_RS06345	COG0697	spore germination
IR188_RS06370	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IR188_RS06385	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
IR188_RS06390	COG1924	4 iron, 4 sulfur cluster binding
IR188_RS06400	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IR188_RS06400	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
IR188_RS06400	COG0674	pyruvate-flavodoxin oxidoreductase activity
IR188_RS06400	COG1013	pyruvate-flavodoxin oxidoreductase activity
IR188_RS06415	COG1683	Conserved Protein
IR188_RS06420	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
IR188_RS06430	COG1953	Uracil, thiamine, allantoin
IR188_RS06450	COG1247	-acetyltransferase
IR188_RS06460	COG2914	Belongs to the UPF0125 (RnfH) family
IR188_RS06465	COG2867	negative regulation of translational initiation
IR188_RS06505	COG1414	Transcriptional regulator
IR188_RS06510	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IR188_RS06515	COG2271	Major facilitator Superfamily
IR188_RS06520	COG2721	sulfolactate sulfo-lyase activity
IR188_RS06525	COG0477	Major facilitator Superfamily
IR188_RS06530	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IR188_RS06535	COG0497	DNA recombination
IR188_RS06540	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
IR188_RS06545	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IR188_RS06550	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
IR188_RS06555	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
IR188_RS06565	COG0513	Belongs to the DEAD box helicase family
IR188_RS06570	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
IR188_RS06585	COG3026	antisigma factor binding
IR188_RS06590	COG3086	response to oxidative stress
IR188_RS06610	COG0681	Belongs to the peptidase S26 family
IR188_RS06615	COG0571	ribonuclease III activity
IR188_RS06620	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
IR188_RS06630	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
IR188_RS06640	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
IR188_RS06685	COG0024	Methionine aminopeptidase
IR188_RS06690	COG1309	transcriptional regulator
IR188_RS06695	COG0477	Major facilitator Superfamily
IR188_RS06710	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
IR188_RS06715	COG0047	phosphoribosylformylglycinamidine synthase activity
IR188_RS06715	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IR188_RS06720	COG4771	TonB-dependent receptor
IR188_RS06725	COG4178	(ABC) transporter
IR188_RS06730	COG0612	Peptidase, M16
IR188_RS06740	COG2205	protein histidine kinase activity
IR188_RS06745	COG3170	Tfp pilus assembly protein FimV
IR188_RS06750	COG2204	response regulator
IR188_RS06755	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
IR188_RS06755	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IR188_RS06760	COG0347	Belongs to the P(II) protein family
IR188_RS06770	COG1017	nitric oxide dioxygenase activity
IR188_RS06770	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IR188_RS06775	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IR188_RS06780	COG2814	Major facilitator Superfamily
IR188_RS06790	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
IR188_RS06795	COG1959	2 iron, 2 sulfur cluster binding
IR188_RS06800	COG1104	cysteine desulfurase activity
IR188_RS06805	COG0822	iron-sulfur transferase activity
IR188_RS06810	COG0316	Belongs to the HesB IscA family
IR188_RS06815	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
IR188_RS06820	COG0443	Heat shock 70 kDa protein
IR188_RS06825	COG0633	Ferredoxin
IR188_RS06830	COG2975	iron-sulfur cluster assembly
IR188_RS06835	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IR188_RS06845	COG2373	Large extracellular alpha-helical protein
IR188_RS06850	COG4953	penicillin-binding protein 1C
IR188_RS06855	COG0105	UTP biosynthetic process
IR188_RS06860	COG0589	response to stress
IR188_RS06865	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IR188_RS06880	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
IR188_RS06885	COG0124	histidyl-tRNA synthetase
IR188_RS06890	COG2976	Protein conserved in bacteria
IR188_RS06895	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IR188_RS06900	COG1160	GTP binding
IR188_RS06930	COG2837	iron assimilation
IR188_RS06935	COG4150	thiosulfate binding
IR188_RS06940	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
IR188_RS06945	COG4208	sulfate ABC transporter
IR188_RS06950	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
IR188_RS06955	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IR188_RS06960	COG0519	Catalyzes the synthesis of GMP from XMP
IR188_RS06975	COG0727	PFAM Uncharacterised protein family (UPF0153)
IR188_RS06980	COG2207	Transcriptional regulator
IR188_RS06985	COG2249	NAD(P)H dehydrogenase (quinone) activity
IR188_RS07000	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IR188_RS07000	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IR188_RS07005	COG2207	Transcriptional regulator
IR188_RS07015	COG2814	Major facilitator Superfamily
IR188_RS07020	COG1560	Kdo2-lipid A biosynthetic process
IR188_RS07055	COG0418	dihydroorotase activity
IR188_RS07065	COG1396	sequence-specific DNA binding
IR188_RS07135	COG0835	chemotaxis
IR188_RS07145	COG0840	transmembrane signaling receptor activity
IR188_RS07150	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
IR188_RS07155	COG2201	protein-glutamate methylesterase activity
IR188_RS07160	COG0745	RESPONSE REGULATOR receiver
IR188_RS07175	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IR188_RS07210	COG1815	bacterial-type flagellum-dependent cell motility
IR188_RS07215	COG1558	bacterial-type flagellum-dependent cell motility
IR188_RS07220	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
IR188_RS07235	COG4786	Flagellar basal body rod
IR188_RS07240	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
IR188_RS07245	COG1706	bacterial-type flagellum-dependent cell motility
IR188_RS07255	COG1256	bacterial-type flagellum assembly
IR188_RS07260	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IR188_RS07270	COG1028	Short-chain dehydrogenase reductase Sdr
IR188_RS07280	COG1987	bacterial-type flagellum assembly
IR188_RS07285	COG1338	Plays a role in the flagellum-specific transport system
IR188_RS07305	COG1580	Controls the rotational direction of flagella during chemotaxis
IR188_RS07310	COG3144	bacterial-type flagellum assembly
IR188_RS07315	COG2882	bacterial-type flagellum organization
IR188_RS07320	COG1157	protein secretion by the type III secretion system
IR188_RS07325	COG1317	bacterial-type flagellum organization
IR188_RS07330	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
IR188_RS07335	COG1766	The M ring may be actively involved in energy transduction
IR188_RS07340	COG1677	Flagellar hook-basal body complex protein FliE
IR188_RS07360	COG3042	response to heat
IR188_RS07405	COG1191	sigma factor activity
IR188_RS07415	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
IR188_RS07415	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
IR188_RS07415	COG0506	proline dehydrogenase activity
IR188_RS07425	COG1113	amino acid transport
IR188_RS07435	COG1216	Glycosyl transferase, family 2
IR188_RS07440	COG2194	sulfuric ester hydrolase activity
IR188_RS07450	COG2252	PERMEase
IR188_RS07465	COG0765	amino acid transport
IR188_RS07480	COG4589	Belongs to the CDS family
IR188_RS07495	COG0626	cystathionine gamma-synthase activity
IR188_RS07500	COG0814	amino acid
IR188_RS07505	COG0633	Ferredoxin
IR188_RS07510	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IR188_RS07515	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IR188_RS07520	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IR188_RS07530	COG2205	protein histidine kinase activity
IR188_RS07530	COG0784	Response regulator, receiver
IR188_RS07535	COG2197	response regulator
IR188_RS07540	COG2198	Histidine kinase
IR188_RS07540	COG0642	Histidine kinase
IR188_RS07575	COG1278	Cold shock
IR188_RS07595	COG0071	Belongs to the small heat shock protein (HSP20) family
IR188_RS07615	COG3772	lysozyme
IR188_RS07680	COG0438	transferase activity, transferring glycosyl groups
IR188_RS07765	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
IR188_RS07780	COG3738	Protein conserved in bacteria
IR188_RS07795	COG3708	Transcriptional regulator
IR188_RS07795	COG2207	Transcriptional regulator
IR188_RS07820	COG0668	transmembrane transport
IR188_RS07825	COG3247	response to pH
IR188_RS07865	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
IR188_RS07865	COG0321	lipoyl(octanoyl) transferase activity
IR188_RS07875	COG1770	oligopeptidase
IR188_RS07880	COG1570	exodeoxyribonuclease VII activity
IR188_RS07885	COG0516	GMP reductase activity
IR188_RS07885	COG0517	IMP dehydrogenase activity
IR188_RS07890	COG0519	Catalyzes the synthesis of GMP from XMP
IR188_RS07890	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IR188_RS07895	COG0582	viral genome integration into host DNA
IR188_RS07995	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
IR188_RS08115	COG3274	enterobacterial common antigen metabolic process
IR188_RS08140	COG1335	isochorismatase
IR188_RS08150	COG2814	Major facilitator Superfamily
IR188_RS08160	COG0823	Involved in the tonB-independent uptake of proteins
IR188_RS08180	COG2226	methyltransferase
IR188_RS08185	COG1971	Probably functions as a manganese efflux pump
IR188_RS08190	COG4811	Protein of unknown function (DUF986)
IR188_RS08195	COG3716	PTS system mannose fructose sorbose family IID component
IR188_RS08200	COG3715	PTS system
IR188_RS08205	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
IR188_RS08205	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IR188_RS08210	COG1760	l-serine dehydratase
IR188_RS08215	COG0494	nUDIX hydrolase
IR188_RS08240	COG1528	Iron-storage protein
IR188_RS08250	COG1276	copper resistance
IR188_RS08260	COG1956	GAF domain-containing protein
IR188_RS08265	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
IR188_RS08275	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IR188_RS08280	COG3189	MarR family transcriptional regulator
IR188_RS08285	COG0113	porphobilinogen synthase activity
IR188_RS08310	COG0589	response to stress
IR188_RS08335	COG2966	Psort location CytoplasmicMembrane, score
IR188_RS08340	COG3610	response to peptide
IR188_RS08350	COG2356	endonuclease I
IR188_RS08355	COG1702	phosphate starvation-inducible protein PhoH
IR188_RS08360	COG2375	cellular response to nickel ion
IR188_RS08370	COG1294	oxidase, subunit
IR188_RS08375	COG1271	oxidase subunit
IR188_RS08380	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IR188_RS08385	COG1280	lysine exporter protein (LysE YggA)
IR188_RS08400	COG1172	Belongs to the binding-protein-dependent transport system permease family
IR188_RS08405	COG1172	Belongs to the binding-protein-dependent transport system permease family
IR188_RS08410	COG1129	ABC transporter
IR188_RS08420	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IR188_RS08425	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IR188_RS08445	COG0012	GTP binding
IR188_RS08450	COG0193	aminoacyl-tRNA hydrolase activity
IR188_RS08460	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IR188_RS08465	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
IR188_RS08470	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
IR188_RS08475	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
IR188_RS08480	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IR188_RS08495	COG2877	3-deoxy-8-phosphooctulonate synthase activity
IR188_RS08500	COG1242	4 iron, 4 sulfur cluster binding
IR188_RS08510	COG0659	secondary active sulfate transmembrane transporter activity
IR188_RS08520	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IR188_RS08525	COG3381	protein complex oligomerization
IR188_RS08530	COG2851	Citrate transporter
IR188_RS08540	COG0477	Major facilitator Superfamily
IR188_RS08545	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IR188_RS08560	COG0018	arginyl-trna synthetase
IR188_RS08565	COG3102	Protein conserved in bacteria
IR188_RS08570	COG3142	Participates in the control of copper homeostasis
IR188_RS08580	COG0500	methyltransferase
IR188_RS08590	COG3788	relative of glutathione S-transferase, MAPEG superfamily
IR188_RS08595	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
IR188_RS08600	COG0494	nUDIX hydrolase
IR188_RS08605	COG0217	transcriptional regulatory protein
IR188_RS08610	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
IR188_RS08615	COG0632	four-way junction helicase activity
IR188_RS08620	COG2255	four-way junction helicase activity
IR188_RS08630	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IR188_RS08635	COG1121	(ABC) transporter
IR188_RS08640	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
IR188_RS08645	COG0739	heme binding
IR188_RS08650	COG1560	Kdo2-lipid A biosynthetic process
IR188_RS08655	COG0469	pyruvate kinase activity
IR188_RS08660	COG1737	Transcriptional regulator
IR188_RS08665	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IR188_RS08670	COG2076	Multidrug Resistance protein
IR188_RS08675	COG2076	Multidrug Resistance protein
IR188_RS08680	COG0745	RESPONSE REGULATOR receiver
IR188_RS08685	COG2205	protein histidine kinase activity
IR188_RS08715	COG1830	Aldolase
IR188_RS08725	COG1172	Belongs to the binding-protein-dependent transport system permease family
IR188_RS08730	COG1172	Belongs to the binding-protein-dependent transport system permease family
IR188_RS08740	COG2390	Transcriptional regulator
IR188_RS08745	COG1070	Carbohydrate kinase
IR188_RS08750	COG0251	oxidation-reduction process
IR188_RS08755	COG1199	ATP-dependent helicase activity
IR188_RS08765	COG3065	identical protein binding
IR188_RS08770	COG0318	PFAM AMP-dependent synthetase and ligase
IR188_RS08775	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
IR188_RS08780	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
IR188_RS08785	COG2894	cell division
IR188_RS08790	COG0850	regulation of cytokinetic process
IR188_RS08795	COG3100	YcgL domain-containing protein
IR188_RS08800	COG2951	lytic endotransglycosylase activity
IR188_RS08805	COG0179	Fumarylacetoacetate (FAA) hydrolase
IR188_RS08810	COG2983	Belongs to the UPF0260 family
IR188_RS08820	COG2226	methyltransferase
IR188_RS08830	COG1120	ATPase activity
IR188_RS08835	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IR188_RS08885	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IR188_RS08890	COG2911	Protein conserved in bacteria
IR188_RS08900	COG3784	Protein of unknown function (DUF1318)
IR188_RS08910	COG1643	Atp-dependent helicase
IR188_RS08915	COG0531	amino acid
IR188_RS08925	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
IR188_RS08930	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
IR188_RS08940	COG0589	response to stress
IR188_RS08950	COG1028	Short-chain dehydrogenase reductase Sdr
IR188_RS08950	COG0604	alcohol dehydrogenase
IR188_RS08950	COG3321	synthase
IR188_RS08955	COG1695	Transcriptional regulator
IR188_RS08965	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
IR188_RS08970	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IR188_RS08970	COG1263	PTS System
IR188_RS08975	COG1609	Transcriptional regulator
IR188_RS08995	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
IR188_RS09025	COG0697	spore germination
IR188_RS09050	COG2850	peptidyl-arginine hydroxylation
IR188_RS09060	COG4628	conserved protein (DUF2132)
IR188_RS09065	COG2897	thiosulfate sulfurtransferase activity
IR188_RS09070	COG2391	methyltransferase activity
IR188_RS09075	COG4771	TonB-dependent receptor
IR188_RS09085	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IR188_RS09090	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
IR188_RS09095	COG1902	pentaerythritol trinitrate reductase activity
IR188_RS09100	COG1309	transcriptional regulator
IR188_RS09105	COG0443	Heat shock 70 kDa protein
IR188_RS09120	COG0402	S-adenosylhomocysteine deaminase activity
IR188_RS09125	COG4807	Protein conserved in bacteria
IR188_RS09170	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IR188_RS09175	COG1671	Belongs to the UPF0178 family
IR188_RS09190	COG0488	(ABC) transporter
IR188_RS09200	COG2076	Multidrug Resistance protein
IR188_RS09215	COG0697	spore germination
IR188_RS09235	COG0494	nUDIX hydrolase
IR188_RS09240	COG1846	Transcriptional regulator
IR188_RS09240	COG0456	acetyltransferase
IR188_RS09245	COG0583	DNA-binding transcription factor activity
IR188_RS09250	COG0814	amino acid
IR188_RS09255	COG0626	cystathionine gamma-synthase activity
IR188_RS09285	COG0590	tRNA wobble adenosine to inosine editing
IR188_RS09290	COG0583	DNA-binding transcription factor activity
IR188_RS09305	COG0477	Major facilitator Superfamily
IR188_RS09325	COG2814	Major facilitator Superfamily
IR188_RS09335	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IR188_RS09405	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IR188_RS09415	COG0789	Transcriptional regulator
IR188_RS09420	COG2814	Major facilitator Superfamily
IR188_RS09460	COG0488	(ABC) transporter
IR188_RS09470	COG2169	Transcriptional regulator
IR188_RS09470	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IR188_RS09475	COG3145	DNA-N1-methyladenine dioxygenase activity
IR188_RS09495	COG2079	MmgE PrpD family protein
IR188_RS09505	COG4221	oxidoreductase activity
IR188_RS09520	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
IR188_RS09525	COG1940	carbohydrate kinase activity
IR188_RS09535	COG0583	DNA-binding transcription factor activity
IR188_RS09540	COG2814	Major facilitator Superfamily
IR188_RS09555	COG0114	fumarate hydratase activity
IR188_RS09560	COG1482	cell wall glycoprotein biosynthetic process
IR188_RS09565	COG5339	Protein conserved in bacteria
IR188_RS09570	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
IR188_RS09575	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
IR188_RS09580	COG0385	Bile acid
IR188_RS09585	COG0673	inositol 2-dehydrogenase activity
IR188_RS09590	COG4657	Part of a membrane complex involved in electron transport
IR188_RS09600	COG4656	Part of a membrane complex involved in electron transport
IR188_RS09610	COG4659	FMN binding
IR188_RS09620	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IR188_RS09625	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
IR188_RS09635	COG0023	Translation Initiation Factor
IR188_RS09640	COG0284	orotidine-5'-phosphate decarboxylase activity
IR188_RS09645	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
IR188_RS09650	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
IR188_RS09655	COG0671	phosphoesterase, PA-phosphatase related
IR188_RS09660	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IR188_RS09675	COG0583	DNA-binding transcription factor activity
IR188_RS09690	COG0616	signal peptide processing
IR188_RS09695	COG1028	Short-chain dehydrogenase reductase Sdr
IR188_RS09710	COG0009	L-threonylcarbamoyladenylate synthase
IR188_RS09725	COG0512	Glutamine amidotransferase of anthranilate synthase
IR188_RS09725	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IR188_RS09730	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IR188_RS09730	COG0512	Glutamine amidotransferase of anthranilate synthase
IR188_RS09735	COG0134	indole-3-glycerol-phosphate synthase activity
IR188_RS09735	COG0135	phosphoribosylanthranilate isomerase activity
IR188_RS09740	COG0133	tryptophan synthase activity
IR188_RS09745	COG0159	tryptophan synthase activity
IR188_RS09755	COG3047	cAMP biosynthetic process
IR188_RS09770	COG3111	PFAM Bacterial OB fold (BOF) protein
IR188_RS09780	COG0642	Histidine kinase
IR188_RS09790	COG2917	probably involved in intracellular septation
IR188_RS09800	COG0513	Belongs to the DEAD box helicase family
IR188_RS09820	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IR188_RS09825	COG3099	Belongs to the UPF0263 family
IR188_RS09850	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IR188_RS09855	COG0601	transmembrane transport
IR188_RS09865	COG4166	transmembrane transport
IR188_RS09870	COG0747	negative chemotaxis
IR188_RS09875	COG0601	transmembrane transport
IR188_RS09880	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IR188_RS09885	COG0444	Belongs to the ABC transporter superfamily
IR188_RS09890	COG4608	Belongs to the ABC transporter superfamily
IR188_RS09895	COG2095	MarC family integral membrane protein
IR188_RS09900	COG1012	belongs to the aldehyde dehydrogenase family
IR188_RS09900	COG1454	alcohol dehydrogenase
IR188_RS09905	COG1435	thymidine kinase activity
IR188_RS09925	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IR188_RS09930	COG0745	RESPONSE REGULATOR receiver
IR188_RS09935	COG3012	SEC-C Motif Domain Protein
IR188_RS09940	COG0788	formyltetrahydrofolate deformylase activity
IR188_RS09955	COG0708	Exodeoxyribonuclease III
IR188_RS09960	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IR188_RS09970	COG0778	Nitroreductase
IR188_RS09975	COG0616	signal peptide processing
IR188_RS09980	COG0252	asparaginase activity
IR188_RS09985	COG1335	isochorismatase
IR188_RS09990	COG3139	Protein of unknown function (DUF1315)
IR188_RS09995	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IR188_RS10000	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IR188_RS10010	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
IR188_RS10015	COG3713	MltA-interacting MipA family protein
IR188_RS10020	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
IR188_RS10025	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IR188_RS10030	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IR188_RS10040	COG2186	Transcriptional regulator
IR188_RS10045	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
IR188_RS10050	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
IR188_RS10055	COG3042	response to heat
IR188_RS10075	COG0488	(ABC) transporter
IR188_RS10110	COG1396	sequence-specific DNA binding
IR188_RS10115	COG1396	sequence-specific DNA binding
IR188_RS10125	COG0598	Magnesium transport protein CorA
IR188_RS10130	COG4166	transmembrane transport
IR188_RS10145	COG3768	UPF0283 membrane protein
IR188_RS10150	COG3106	COG3106 Predicted ATPase
IR188_RS10160	COG1983	PspC domain protein
IR188_RS10170	COG1842	Phage shock protein A
IR188_RS10175	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
IR188_RS10180	COG4166	transmembrane transport
IR188_RS10190	COG4171	peptide transport system, permease
IR188_RS10200	COG4172	Belongs to the ABC transporter superfamily
IR188_RS10235	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
IR188_RS10240	COG3133	Outer membrane lipoprotein
IR188_RS10245	COG1846	Transcriptional regulator
IR188_RS10250	COG3313	Fe-S protein
IR188_RS10255	COG0346	lactoylglutathione lyase activity
IR188_RS10270	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IR188_RS10275	COG1280	lysine exporter protein (LysE YggA)
IR188_RS10290	COG3122	Protein conserved in bacteria
IR188_RS10310	COG1609	Transcriptional regulator
IR188_RS10315	COG0583	DNA-binding transcription factor activity
IR188_RS10320	COG2814	Major facilitator Superfamily
IR188_RS10325	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IR188_RS10330	COG0307	riboflavin synthase, alpha
IR188_RS10335	COG0534	Mate efflux family protein
IR188_RS10360	COG1376	ErfK ybiS ycfS ynhG family protein
IR188_RS10360	COG1388	LysM domain
IR188_RS10365	COG2166	iron-sulfur cluster assembly
IR188_RS10370	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IR188_RS10375	COG0719	Fe-S assembly protein
IR188_RS10380	COG0396	ATPase activity
IR188_RS10385	COG0719	Fe-S assembly protein
IR188_RS10390	COG0316	Belongs to the HesB IscA family
IR188_RS10395	COG2050	protein possibly involved in aromatic compounds catabolism
IR188_RS10400	COG0247	lactate metabolic process
IR188_RS10400	COG0277	FAD linked oxidase domain protein
IR188_RS10405	COG0628	permease
IR188_RS10410	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IR188_RS10410	COG0574	Belongs to the PEP-utilizing enzyme family
IR188_RS10415	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
IR188_RS10420	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IR188_RS10425	COG4256	Hemin uptake protein
IR188_RS10430	COG3720	iron ion transport
IR188_RS10435	COG4558	Periplasmic binding protein
IR188_RS10440	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IR188_RS10445	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
IR188_RS10455	COG2207	Transcriptional regulator
IR188_RS10470	COG0791	NLP P60 protein
IR188_RS10475	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
IR188_RS10480	COG2076	Multidrug Resistance protein
IR188_RS10485	COG2076	Multidrug Resistance protein
IR188_RS10490	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
IR188_RS10495	COG0726	polysaccharide deacetylase
IR188_RS10500	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IR188_RS10500	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IR188_RS10505	COG0463	Glycosyl transferase, family 2
IR188_RS10510	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IR188_RS10515	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
IR188_RS10520	COG4139	cobalamin transport
IR188_RS10525	COG0776	regulation of translation
IR188_RS10530	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IR188_RS10530	COG0072	phenylalanine-tRNA ligase activity
IR188_RS10535	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IR188_RS10550	COG0291	Belongs to the bacterial ribosomal protein bL35 family
IR188_RS10560	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
IR188_RS10565	COG2194	sulfuric ester hydrolase activity
IR188_RS10575	COG0803	Belongs to the bacterial solute-binding protein 9 family
IR188_RS10580	COG1121	(ABC) transporter
IR188_RS10585	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IR188_RS10590	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IR188_RS10595	COG3001	Fructosamine kinase
IR188_RS10605	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IR188_RS10610	COG1988	membrane-bound metal-dependent
IR188_RS10615	COG1823	symporter activity
IR188_RS10620	COG0501	Belongs to the peptidase M48B family
IR188_RS10625	COG0346	lactoylglutathione lyase activity
IR188_RS10630	COG0281	malic enzyme
IR188_RS10630	COG0280	phosphate acetyltransferase
IR188_RS10635	COG2197	response regulator
IR188_RS10645	COG1393	Belongs to the ArsC family
IR188_RS10655	COG1876	peptidase activity
IR188_RS10660	COG2832	Protein of unknown function (DUF454)
IR188_RS10675	COG1444	tRNA N-acetyltransferase activity
IR188_RS10680	COG2707	UPF0756 membrane protein
IR188_RS10685	COG2321	neutral zinc metallopeptidase
IR188_RS10690	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
IR188_RS10695	COG1349	DNA-binding transcription factor activity
IR188_RS10700	COG0483	inositol monophosphate 1-phosphatase activity
IR188_RS10705	COG2223	nitrite transmembrane transporter activity
IR188_RS10710	COG1216	Glycosyl transferase, family 2
IR188_RS10715	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
IR188_RS10725	COG2716	regulation of RNA biosynthetic process
IR188_RS10730	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IR188_RS10735	COG3210	domain, Protein
IR188_RS10740	COG0628	permease
IR188_RS10745	COG4783	chaperone-mediated protein folding
IR188_RS10750	COG1393	Belongs to the ArsC family
IR188_RS10775	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IR188_RS10780	COG2267	carboxylic ester hydrolase activity
IR188_RS10785	COG0671	phosphoesterase, PA-phosphatase related
IR188_RS10785	COG2453	phosphatase
IR188_RS10795	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IR188_RS10800	COG2233	PERMEase
IR188_RS10805	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
IR188_RS10810	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
IR188_RS10815	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IR188_RS10825	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IR188_RS10830	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
IR188_RS10835	COG0248	Ppx GppA phosphatase
IR188_RS10840	COG2239	Acts as a magnesium transporter
IR188_RS10865	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IR188_RS10870	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IR188_RS10875	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IR188_RS10880	COG2205	protein histidine kinase activity
IR188_RS10885	COG0745	RESPONSE REGULATOR receiver
IR188_RS10895	COG0826	peptidase U32
IR188_RS10900	COG1597	lipid kinase activity
IR188_RS10905	COG1830	Aldolase
IR188_RS10910	COG1187	pseudouridine synthase activity
IR188_RS10915	COG0351	phosphomethylpyrimidine kinase
IR188_RS10930	COG1113	amino acid transport
IR188_RS10940	COG2207	Transcriptional regulator
IR188_RS10945	COG0561	phosphatase activity
IR188_RS10950	COG1114	Component of the transport system for branched-chain amino acids
IR188_RS10955	COG3023	N-Acetylmuramoyl-L-alanine amidase
IR188_RS10970	COG1115	amino acid carrier protein
IR188_RS10990	COG1584	GPR1 FUN34 yaaH family protein
IR188_RS11005	COG0318	PFAM AMP-dependent synthetase and ligase
IR188_RS11010	COG1441	menaquinone biosynthetic process
IR188_RS11020	COG0596	Alpha beta hydrolase
IR188_RS11025	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
IR188_RS11030	COG1169	isochorismate synthase
IR188_RS11045	COG1007	ATP synthesis coupled electron transport
IR188_RS11050	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IR188_RS11055	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IR188_RS11060	COG0713	ATP synthesis coupled electron transport
IR188_RS11065	COG0839	Belongs to the complex I subunit 6 family
IR188_RS11070	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IR188_RS11075	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
IR188_RS11095	COG0649	NAD binding
IR188_RS11095	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IR188_RS11105	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IR188_RS11110	COG0583	DNA-binding transcription factor activity
IR188_RS11115	COG0436	Aminotransferase
IR188_RS11120	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
IR188_RS11125	COG0490	domain, Protein
IR188_RS11125	COG0471	metal ion transport
IR188_RS11130	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IR188_RS11135	COG3013	Belongs to the UPF0304 family
IR188_RS11140	COG3092	negative regulation of chromosome organization
IR188_RS11145	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
IR188_RS11150	COG0280	phosphate acetyltransferase
IR188_RS11150	COG0857	belongs to the CobB CobQ family
IR188_RS11165	COG1090	epimerase
IR188_RS11170	COG0163	prenyltransferase activity
IR188_RS11175	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
IR188_RS11180	COG1286	toxin biosynthetic process
IR188_RS11185	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
IR188_RS11190	COG0285	dihydrofolate synthase activity
IR188_RS11195	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
IR188_RS11200	COG0586	Pfam SNARE associated Golgi protein
IR188_RS11205	COG0101	tRNA pseudouridine synthase activity
IR188_RS11210	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IR188_RS11215	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IR188_RS11225	COG0697	spore germination
IR188_RS11245	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IR188_RS11250	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
IR188_RS11250	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IR188_RS11275	COG3101	peptidyl-lysine hydroxylation
IR188_RS11280	COG0730	response to heat
IR188_RS11285	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
IR188_RS11295	COG2840	Smr protein MutS2
IR188_RS11300	COG2062	phosphohistidine phosphatase, SixA
IR188_RS11305	COG1024	Enoyl-CoA hydratase
IR188_RS11305	COG1250	3-hydroxyacyl-CoA dehydrogenase
IR188_RS11310	COG0183	Belongs to the thiolase family
IR188_RS11315	COG3691	Protein conserved in bacteria
IR188_RS11330	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
IR188_RS11335	COG3048	D-serine ammonia-lyase activity
IR188_RS11340	COG2610	gluconate transmembrane transporter activity
IR188_RS11345	COG0583	DNA-binding transcription factor activity
IR188_RS11355	COG0582	viral genome integration into host DNA
IR188_RS11525	COG3646	Phage regulatory protein
IR188_RS11595	COG1484	DNA-dependent DNA replication
IR188_RS11640	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IR188_RS11645	COG3723	Recombinational DNA repair protein, rece pathway
IR188_RS11710	COG3772	lysozyme
IR188_RS11735	COG1464	Belongs to the NlpA lipoprotein family
IR188_RS11765	COG3422	double-strand break repair
IR188_RS11775	COG2841	Protein conserved in bacteria
IR188_RS11800	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IR188_RS11805	COG2315	Protein conserved in bacteria
IR188_RS11815	COG0702	epimerase
IR188_RS11820	COG1733	regulation of RNA biosynthetic process
IR188_RS11825	COG0582	viral genome integration into host DNA
IR188_RS11835	COG0538	isocitrate dehydrogenase activity
IR188_RS11840	COG1187	pseudouridine synthase activity
IR188_RS11850	COG0482	sulfurtransferase activity
IR188_RS11855	COG2915	High frequency lysogenization protein hflD homolog
IR188_RS11860	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IR188_RS11865	COG0745	RESPONSE REGULATOR receiver
IR188_RS11875	COG2850	peptidyl-arginine hydroxylation
IR188_RS11885	COG3188	usher protein
IR188_RS11890	COG3121	Chaperone
IR188_RS11910	COG4591	ABC-type transport system involved in lipoprotein release permease component
IR188_RS11915	COG1136	(ABC) transporter
IR188_RS11920	COG4591	ABC-type transport system involved in lipoprotein release permease component
IR188_RS11925	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IR188_RS11930	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IR188_RS11945	COG1252	NADH dehydrogenase
IR188_RS11950	COG3150	esterase
IR188_RS11955	COG1472	Belongs to the glycosyl hydrolase 3 family
IR188_RS11965	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
IR188_RS11970	COG0537	adenosine 5'-monophosphoramidase activity
IR188_RS11975	COG0084	hydrolase, TatD family'
IR188_RS11980	COG0470	DNA polymerase III
IR188_RS11990	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IR188_RS11995	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IR188_RS12000	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IR188_RS12005	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IR188_RS12015	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
IR188_RS12020	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IR188_RS12025	COG0416	fatty acid biosynthetic process
IR188_RS12030	COG0333	Belongs to the bacterial ribosomal protein bL32 family
IR188_RS12035	COG1399	metal-binding, possibly nucleic acid-binding protein
IR188_RS12040	COG0424	maF-like protein
IR188_RS12050	COG0564	pseudouridine synthase activity
IR188_RS12055	COG1530	ribonuclease E activity
IR188_RS12060	COG2926	Belongs to the UPF0265 family
IR188_RS12065	COG2925	Exonuclease
IR188_RS12075	COG0277	FAD linked oxidase domain protein
IR188_RS12080	COG0730	response to heat
IR188_RS12085	COG0531	amino acid
IR188_RS12090	COG4771	TonB-dependent receptor
IR188_RS12095	COG1120	ATPase activity
IR188_RS12100	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IR188_RS12110	COG0833	amino acid
IR188_RS12115	COG0583	DNA-binding transcription factor activity
IR188_RS12120	COG2855	membrane
IR188_RS12125	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
IR188_RS12130	COG1105	Belongs to the carbohydrate kinase PfkB family
IR188_RS12135	COG0494	nUDIX hydrolase
IR188_RS12140	COG0814	amino acid
IR188_RS12145	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IR188_RS12160	COG0671	phosphoesterase, PA-phosphatase related
IR188_RS12165	COG0791	NLP P60 protein
IR188_RS12175	COG2814	Major facilitator Superfamily
IR188_RS12180	COG1187	pseudouridine synthase activity
IR188_RS12185	COG1061	Type III restriction enzyme res subunit
IR188_RS12190	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
IR188_RS12195	COG3081	Nucleoid-associated protein
IR188_RS12200	COG3082	Protein of unknown function (DUF1414)
IR188_RS12205	COG3083	sulfuric ester hydrolase activity
IR188_RS12215	COG1278	Cold shock
IR188_RS12220	COG3969	phosphoadenosine phosphosulfate
IR188_RS12225	COG1475	DNA binding
IR188_RS12235	COG0730	response to heat
IR188_RS12245	COG0586	Pfam SNARE associated Golgi protein
IR188_RS12255	COG1278	Cold shock
IR188_RS12275	COG2814	Major facilitator Superfamily
IR188_RS12285	COG1032	radical SAM domain protein
IR188_RS12305	COG1032	radical SAM domain protein
IR188_RS12310	COG1032	radical SAM domain protein
IR188_RS12320	COG1032	radical SAM domain protein
IR188_RS12495	COG2369	cell adhesion
IR188_RS12530	COG3772	lysozyme
IR188_RS12540	COG3272	Protein of unknown function (DUF1722)
IR188_RS12595	COG4626	Terminase
IR188_RS12595	COG1802	Transcriptional regulator
IR188_RS12685	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IR188_RS12690	COG0322	excinuclease ABC activity
IR188_RS12695	COG2197	response regulator
IR188_RS12700	COG0778	Nitroreductase
IR188_RS12710	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IR188_RS12715	COG1028	Short-chain dehydrogenase reductase Sdr
IR188_RS12720	COG2837	iron assimilation
IR188_RS12725	COG2822	iron ion transport
IR188_RS12735	COG4633	Protein conserved in bacteria
IR188_RS12830	COG3530	Putative quorum-sensing-regulated virulence factor
IR188_RS12835	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IR188_RS12840	COG3115	cell septum assembly
IR188_RS12855	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IR188_RS12860	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IR188_RS12890	COG3135	benzoate transporter
IR188_RS12895	COG1396	sequence-specific DNA binding
IR188_RS12920	COG1309	transcriptional regulator
IR188_RS12935	COG2246	polysaccharide biosynthetic process
IR188_RS13055	COG3728	DNA packaging
IR188_RS13055	COG5484	DNA packaging
IR188_RS13240	COG0582	viral genome integration into host DNA
IR188_RS13265	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IR188_RS13270	COG0813	purine-nucleoside phosphorylase activity
IR188_RS13285	COG0477	Major facilitator Superfamily
IR188_RS13295	COG4771	TonB-dependent receptor
IR188_RS13300	COG1609	Transcriptional regulator
IR188_RS13305	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IR188_RS13310	COG2017	converts alpha-aldose to the beta-anomer
IR188_RS13315	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
IR188_RS13320	COG1085	galactose-1-phosphate uridylyltransferase
IR188_RS13325	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IR188_RS13330	COG1609	Transcriptional regulator
IR188_RS13335	COG3250	beta-galactosidase activity
IR188_RS13340	COG2731	YhcH YjgK YiaL family protein
IR188_RS13345	COG0531	amino acid
IR188_RS13355	COG2233	PERMEase
IR188_RS13375	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
IR188_RS13395	COG2841	Protein conserved in bacteria
IR188_RS13415	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IR188_RS13425	COG3842	ATPase activity
IR188_RS13430	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
IR188_RS13435	COG0725	ABC transporter, periplasmic molybdate-binding protein
IR188_RS13455	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
IR188_RS13470	COG0583	DNA-binding transcription factor activity
IR188_RS13505	COG1309	transcriptional regulator
IR188_RS13510	COG0531	amino acid
IR188_RS13515	COG1982	Orn Lys Arg decarboxylase major
IR188_RS13530	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
IR188_RS13540	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IR188_RS13545	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IR188_RS13555	COG0716	FMN binding
IR188_RS13570	COG0354	folic acid binding
IR188_RS13580	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IR188_RS13580	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IR188_RS13585	COG0509	glycine decarboxylation via glycine cleavage system
IR188_RS13590	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IR188_RS13595	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IR188_RS13600	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IR188_RS13605	COG0006	proline dipeptidase activity
IR188_RS13610	COG3079	Belongs to the UPF0149 family
IR188_RS13625	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IR188_RS13630	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IR188_RS13635	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
IR188_RS13640	COG0583	DNA-binding transcription factor activity
IR188_RS13650	COG1279	arginine transmembrane transporter activity
IR188_RS13660	COG0668	transmembrane transport
IR188_RS13665	COG3112	Uncharacterised protein family (UPF0231)
IR188_RS13670	COG1049	propionate catabolic process, 2-methylcitrate cycle
IR188_RS13675	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IR188_RS13680	COG0508	dehydrogenase complex catalyzes the overall conversion of
IR188_RS13685	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
IR188_RS13695	COG3023	N-Acetylmuramoyl-L-alanine amidase
IR188_RS13700	COG4969	Belongs to the N-Me-Phe pilin family
IR188_RS13705	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IR188_RS13715	COG0237	dephospho-CoA kinase activity
IR188_RS13720	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
IR188_RS13730	COG0494	nUDIX hydrolase
IR188_RS13735	COG0653	protein targeting
IR188_RS13750	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
IR188_RS13755	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
IR188_RS13760	COG0849	cell division
IR188_RS13765	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
IR188_RS13775	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IR188_RS13780	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IR188_RS13785	COG0772	Belongs to the SEDS family
IR188_RS13795	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IR188_RS13800	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IR188_RS13805	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IR188_RS13810	COG0768	penicillin binding
IR188_RS13815	COG3116	cell division
IR188_RS13820	COG0275	rRNA processing
IR188_RS13825	COG2001	Belongs to the MraZ family
IR188_RS13840	COG0028	Belongs to the TPP enzyme family
IR188_RS13845	COG1022	Amp-dependent synthetase and ligase
IR188_RS13855	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IR188_RS13860	COG0473	3-isopropylmalate dehydrogenase activity
IR188_RS13865	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
IR188_RS13875	COG4533	DNA binding
IR188_RS13880	COG3066	DNA modification
IR188_RS13900	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IR188_RS13915	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IR188_RS13930	COG0583	DNA-binding transcription factor activity
IR188_RS13950	COG1129	ABC transporter
IR188_RS13960	COG0010	Belongs to the arginase family
IR188_RS13965	COG1166	arginine decarboxylase activity
IR188_RS13970	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IR188_RS13985	COG0640	Transcriptional regulator
IR188_RS13995	COG2239	Acts as a magnesium transporter
IR188_RS14005	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IR188_RS14010	COG1151	hydroxylamine reductase activity
IR188_RS14015	COG4772	TonB-dependent receptor
IR188_RS14025	COG1115	amino acid carrier protein
IR188_RS14045	COG2814	Major facilitator Superfamily
IR188_RS14050	COG1566	PFAM secretion protein HlyD family protein
IR188_RS14060	COG2353	YceI-like domain
IR188_RS14065	COG3038	cytochrome b561
IR188_RS14100	COG2390	Transcriptional regulator
IR188_RS14105	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IR188_RS14110	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IR188_RS14115	COG1129	ABC transporter
IR188_RS14115	COG0842	Transport permease protein
IR188_RS14120	COG0842	Transport permease protein
IR188_RS14125	COG1609	Transcriptional regulator
IR188_RS14140	COG1070	Carbohydrate kinase
IR188_RS14145	COG1129	ABC transporter
IR188_RS14150	COG1172	Belongs to the binding-protein-dependent transport system permease family
IR188_RS14155	COG1879	ABC-type sugar transport system periplasmic component
IR188_RS14165	COG3961	Belongs to the TPP enzyme family
IR188_RS14180	COG1349	DNA-binding transcription factor activity
IR188_RS14190	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IR188_RS14200	COG3716	PTS system mannose fructose sorbose family IID component
IR188_RS14205	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
IR188_RS14210	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IR188_RS14215	COG2222	sugar isomerase
IR188_RS14225	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IR188_RS14225	COG1263	PTS System
IR188_RS14235	COG2233	PERMEase
IR188_RS14240	COG0493	'glutamate synthase
IR188_RS14240	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
IR188_RS14245	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IR188_RS14250	COG2313	pseudouridylate synthase activity
IR188_RS14255	COG1522	sequence-specific DNA binding
IR188_RS14255	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IR188_RS14260	COG3443	Belongs to the bacterial solute-binding protein 9 family
IR188_RS14265	COG0257	Belongs to the bacterial ribosomal protein bL36 family
IR188_RS14270	COG0254	rRNA binding
IR188_RS14275	COG0754	glutathionylspermidine amidase activity
IR188_RS14280	COG2233	PERMEase
IR188_RS14290	COG1064	alcohol dehydrogenase
IR188_RS14325	COG0604	alcohol dehydrogenase
IR188_RS14330	COG1309	transcriptional regulator
IR188_RS14340	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
IR188_RS14355	COG0640	Transcriptional regulator
IR188_RS14480	COG4695	Portal protein
IR188_RS14490	COG4626	Terminase
IR188_RS14490	COG1802	Transcriptional regulator
IR188_RS14515	COG3772	lysozyme
IR188_RS14545	COG1403	HNH endonuclease
IR188_RS14610	COG5532	Uncharacterized conserved protein (DUF2303)
IR188_RS14620	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
IR188_RS14640	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IR188_RS14645	COG2501	S4 domain
IR188_RS14650	COG3038	cytochrome b561
IR188_RS14655	COG3783	Cytochrome b(562)
IR188_RS14665	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IR188_RS14670	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IR188_RS14675	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
IR188_RS14680	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
IR188_RS14690	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
IR188_RS14695	COG4181	ATPase activity
IR188_RS14700	COG2755	lipolytic protein G-D-S-L family
IR188_RS14705	COG0300	oxidoreductase activity
IR188_RS14710	COG3118	belongs to the thioredoxin family
IR188_RS14715	COG0330	HflC and HflK could
IR188_RS14720	COG1585	Membrane protein implicated in regulation of membrane protease activity
IR188_RS14730	COG3041	Addiction module toxin RelE StbE family
IR188_RS14735	COG3077	Addiction module antitoxin, RelB DinJ family
IR188_RS14755	COG2217	Heavy metal translocating P-type atpase
IR188_RS14760	COG3735	TraB family
IR188_RS14765	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IR188_RS14775	COG0737	Belongs to the 5'-nucleotidase family
IR188_RS14780	COG4651	solute:proton antiporter activity
IR188_RS14780	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IR188_RS14785	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IR188_RS14790	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
IR188_RS14795	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
IR188_RS14810	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
IR188_RS14815	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
IR188_RS14825	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IR188_RS14840	COG3264	Mechanosensitive ion channel
IR188_RS14840	COG1196	nuclear chromosome segregation
IR188_RS14845	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
IR188_RS14850	COG1309	transcriptional regulator
IR188_RS14855	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IR188_RS14860	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IR188_RS14880	COG1946	Acyl-CoA thioesterase
IR188_RS14885	COG0004	ammonium transporteR
IR188_RS14890	COG0347	Belongs to the P(II) protein family
IR188_RS14895	COG1132	(ABC) transporter
IR188_RS14900	COG1132	(ABC) transporter
IR188_RS14905	COG1522	sequence-specific DNA binding
IR188_RS14920	COG0824	Thioesterase
IR188_RS14925	COG1555	photosystem II stabilization
IR188_RS14930	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IR188_RS14940	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IR188_RS14945	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
IR188_RS14950	COG0740	serine-type endopeptidase activity
IR188_RS14955	COG0544	peptidyl-prolyl cis-trans isomerase activity
IR188_RS14960	COG0271	Belongs to the BolA IbaG family
IR188_RS14965	COG3056	Lipoprotein
IR188_RS14970	COG2223	nitrite transmembrane transporter activity
IR188_RS14980	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IR188_RS14985	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IR188_RS14990	COG1845	cytochrome c oxidase, subunit III
IR188_RS14995	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
IR188_RS15000	COG0109	protoheme IX farnesyltransferase activity
IR188_RS15005	COG2814	Major facilitator Superfamily
IR188_RS15010	COG1666	GTP binding
IR188_RS15015	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
IR188_RS15020	COG0693	protein deglycase activity
IR188_RS15030	COG0301	tRNA thio-modification
IR188_RS15030	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IR188_RS15040	COG0142	geranyltranstransferase activity
IR188_RS15045	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IR188_RS15050	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
IR188_RS15055	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IR188_RS15060	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
IR188_RS15065	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IR188_RS15065	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IR188_RS15070	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
IR188_RS15075	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IR188_RS15080	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IR188_RS15085	COG1862	Preprotein translocase
IR188_RS15090	COG0343	queuine tRNA-ribosyltransferase activity
IR188_RS15095	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
IR188_RS15100	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
IR188_RS15105	COG0450	alkyl hydroperoxide reductase
IR188_RS15115	COG5002	protein histidine kinase activity
IR188_RS15120	COG0745	RESPONSE REGULATOR receiver
IR188_RS15125	COG0420	3'-5' exonuclease activity
IR188_RS15130	COG0419	ATPase involved in DNA repair
IR188_RS15140	COG1940	carbohydrate kinase activity
IR188_RS15145	COG2974	May be involved in recombination
IR188_RS15160	COG0425	Belongs to the sulfur carrier protein TusA family
IR188_RS15165	COG2391	methyltransferase activity
IR188_RS15170	COG0309	Hydrogenase expression formation protein (HypE)
IR188_RS15175	COG0409	Hydrogenase expression formation protein
IR188_RS15180	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
IR188_RS15185	COG1968	undecaprenyl-diphosphatase activity
IR188_RS15190	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IR188_RS15195	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
IR188_RS15200	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IR188_RS15205	COG0828	Belongs to the bacterial ribosomal protein bS21 family
IR188_RS15210	COG0358	DNA primase activity
IR188_RS15230	COG4953	penicillin-binding protein 1C
IR188_RS15235	COG2373	Large extracellular alpha-helical protein
IR188_RS15255	COG1773	rubredoxin
IR188_RS15260	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
IR188_RS15265	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
IR188_RS15270	COG5557	Pfam Polysulphide reductase, NrfD
IR188_RS15275	COG0437	4 iron, 4 sulfur cluster binding
IR188_RS15280	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
IR188_RS15285	COG0733	neurotransmitter:sodium symporter activity
IR188_RS15295	COG2990	Protein conserved in bacteria
IR188_RS15300	COG0586	Pfam SNARE associated Golgi protein
IR188_RS15305	COG4575	ribosome binding
IR188_RS15310	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
IR188_RS15320	COG2259	Doxx family
IR188_RS15330	COG0583	DNA-binding transcription factor activity
IR188_RS15335	COG1741	Belongs to the pirin family
IR188_RS15345	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
IR188_RS15355	COG0792	nuclease activity
IR188_RS15360	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
IR188_RS15365	COG2823	Periplasmic or secreted lipoprotein
IR188_RS15370	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IR188_RS15375	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
IR188_RS15380	COG0784	Response regulator, receiver
IR188_RS15380	COG2198	Histidine kinase
IR188_RS15380	COG5002	protein histidine kinase activity
IR188_RS15385	COG0070	glutamate synthase
IR188_RS15385	COG0069	glutamate synthase activity
IR188_RS15385	COG0067	glutamate synthase
IR188_RS15390	COG0493	'glutamate synthase
IR188_RS15395	COG2969	positive regulation of protein catabolic process
IR188_RS15400	COG0625	glutathione transferase activity
IR188_RS15405	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IR188_RS15410	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IR188_RS15415	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
IR188_RS15420	COG3105	Protein conserved in bacteria
IR188_RS15425	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IR188_RS15430	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IR188_RS15435	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
IR188_RS15440	COG4521	taurine ABC transporter
IR188_RS15445	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
IR188_RS15450	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IR188_RS15455	COG2175	clavaminate synthase activity
IR188_RS15460	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IR188_RS15465	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IR188_RS15470	COG5007	Belongs to the BolA IbaG family
IR188_RS15480	COG2854	intermembrane phospholipid transfer
IR188_RS15485	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IR188_RS15490	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IR188_RS15495	COG1127	ABC transporter
IR188_RS15500	COG0530	calcium, potassium:sodium antiporter activity
IR188_RS15505	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
IR188_RS15505	COG0517	IMP dehydrogenase activity
IR188_RS15510	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
IR188_RS15515	COG3117	lipopolysaccharide transmembrane transporter activity
IR188_RS15520	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
IR188_RS15525	COG1137	ATPase activity
IR188_RS15530	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
IR188_RS15535	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
IR188_RS15545	COG1660	Displays ATPase and GTPase activities
IR188_RS15550	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IR188_RS15555	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IR188_RS15570	COG0312	modulator of DNA gyrase
IR188_RS15575	COG3028	Belongs to the UPF0307 family
IR188_RS15580	COG2732	(Barnase) inhibitor
IR188_RS15585	COG4290	ribonuclease
IR188_RS15590	COG0312	modulator of DNA gyrase
IR188_RS15595	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IR188_RS15600	COG3164	Protein of unknown function
IR188_RS15615	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
IR188_RS15620	COG1792	Involved in formation and maintenance of cell shape
IR188_RS15625	COG1077	Cell shape determining protein MreB Mrl
IR188_RS15630	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
IR188_RS15635	COG0511	ligase activity, forming carbon-carbon bonds
IR188_RS15640	COG0439	Biotin carboxylase
IR188_RS15645	COG2264	protein methyltransferase activity
IR188_RS15650	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IR188_RS15655	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
IR188_RS15670	COG0477	Major facilitator Superfamily
IR188_RS15675	COG4774	siderophore transport
IR188_RS15680	COG0402	S-adenosylhomocysteine deaminase activity
IR188_RS15685	COG0840	transmembrane signaling receptor activity
IR188_RS15690	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
IR188_RS15695	COG0745	RESPONSE REGULATOR receiver
IR188_RS15700	COG2205	protein histidine kinase activity
IR188_RS15705	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
IR188_RS15725	COG0454	-acetyltransferase
IR188_RS15735	COG0410	ABC transporter
IR188_RS15740	COG0411	ABC transporter
IR188_RS15745	COG4177	L-phenylalanine transmembrane transporter activity
IR188_RS15750	COG0559	Belongs to the binding-protein-dependent transport system permease family
IR188_RS15770	COG1929	Belongs to the glycerate kinase type-1 family
IR188_RS15775	COG2610	gluconate transmembrane transporter activity
IR188_RS15780	COG3835	regulator
IR188_RS15795	COG2177	Part of the ABC transporter FtsEX involved in
IR188_RS15800	COG2884	Cell division ATP-binding protein ftsE
IR188_RS15805	COG0552	protein localization to endoplasmic reticulum
IR188_RS15805	COG0552	protein localization to endoplasmic reticulum
IR188_RS15810	COG0742	ribosomal rna small subunit methyltransferase
IR188_RS15815	COG3776	membrane
IR188_RS15825	COG3714	YhhN family
IR188_RS15835	COG3739	integral membrane protein
IR188_RS15840	COG0425	Belongs to the sulfur carrier protein TusA family
IR188_RS15845	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
IR188_RS15860	COG0247	lactate metabolic process
IR188_RS15870	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
IR188_RS15875	COG1053	succinate dehydrogenase
IR188_RS15880	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IR188_RS15885	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
IR188_RS15895	COG1621	beta-fructofuranosidase activity
IR188_RS15900	COG0298	carbon dioxide binding
IR188_RS15905	COG0375	protein maturation
IR188_RS15910	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
IR188_RS15915	COG3604	Transcriptional regulator
IR188_RS15945	COG1966	Carbon starvation protein
IR188_RS15950	COG2879	small protein
IR188_RS15960	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
IR188_RS15970	COG3260	NADH ubiquinone oxidoreductase 20
IR188_RS15975	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IR188_RS15980	COG3261	NADH dehydrogenase
IR188_RS15980	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
IR188_RS15985	COG0651	ATP synthesis coupled electron transport
IR188_RS15990	COG4237	Hydrogenase 4 membrane
IR188_RS15995	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IR188_RS16000	COG0650	Formate hydrogenlyase subunit 4
IR188_RS16005	COG0651	ATP synthesis coupled electron transport
IR188_RS16010	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
IR188_RS16015	COG2194	sulfuric ester hydrolase activity
IR188_RS16025	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IR188_RS16035	COG2226	methyltransferase
IR188_RS16050	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IR188_RS16055	COG1263	PTS System
IR188_RS16055	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IR188_RS16060	COG1737	Transcriptional regulator
IR188_RS16065	COG0459	protein refolding
IR188_RS16085	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
IR188_RS16090	COG1309	transcriptional regulator
IR188_RS16110	COG1396	sequence-specific DNA binding
IR188_RS16130	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IR188_RS16135	COG0601	transmembrane transport
IR188_RS16140	COG0747	negative chemotaxis
IR188_RS16145	COG2824	Alkylphosphonate utilization operon protein PhnA
IR188_RS16150	COG1396	sequence-specific DNA binding
IR188_RS16155	COG0582	viral genome integration into host DNA
IR188_RS16180	COG3121	Chaperone
IR188_RS16185	COG3188	usher protein
IR188_RS16200	COG0582	viral genome integration into host DNA
IR188_RS16225	COG3539	Fimbrial protein
IR188_RS16235	COG3188	usher protein
IR188_RS16245	COG3539	Fimbrial protein
IR188_RS16250	COG0582	viral genome integration into host DNA
IR188_RS16255	COG1957	nucleoside hydrolase
IR188_RS16260	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
IR188_RS16295	COG2137	regulation of response to DNA damage stimulus
IR188_RS16325	COG2992	FlgJ-related protein
IR188_RS16330	COG1696	Membrane protein involved in D-alanine export
IR188_RS16345	COG0124	histidyl-tRNA synthetase
IR188_RS16350	COG0531	amino acid
IR188_RS16360	COG0531	amino acid
IR188_RS16365	COG0124	histidyl-tRNA synthetase
IR188_RS16370	COG2188	Transcriptional regulator
IR188_RS16375	COG1397	ADP-ribosylglycohydrolase
IR188_RS16385	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IR188_RS16395	COG2610	gluconate transmembrane transporter activity
IR188_RS16400	COG3265	gluconokinase activity
IR188_RS16405	COG1609	Transcriptional regulator
IR188_RS16415	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IR188_RS16420	COG1120	ATPase activity
IR188_RS16425	COG0500	methyltransferase
IR188_RS16430	COG0157	Belongs to the NadC ModD family
IR188_RS16450	COG4978	Transcriptional regulator
IR188_RS16450	COG0789	Transcriptional regulator
IR188_RS16455	COG0668	transmembrane transport
IR188_RS16510	COG4790	Type iii secretion
IR188_RS16555	COG2207	Transcriptional regulator
IR188_RS16595	COG1396	sequence-specific DNA binding
IR188_RS16600	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
IR188_RS16605	COG1177	transmembrane transport
IR188_RS16635	COG2814	Major facilitator Superfamily
IR188_RS16670	COG2373	Large extracellular alpha-helical protein
IR188_RS16670	COG4932	domain protein
IR188_RS16670	COG1388	LysM domain
IR188_RS16685	COG0584	glycerophosphoryl diester phosphodiesterase
IR188_RS16690	COG2197	response regulator
IR188_RS16695	COG3850	Histidine kinase
IR188_RS16700	COG2223	nitrite transmembrane transporter activity
IR188_RS16705	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
IR188_RS16710	COG1140	nitrate reductase beta subunit
IR188_RS16715	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
IR188_RS16720	COG2181	nitrate reductase activity
IR188_RS16735	COG1280	lysine exporter protein (LysE YggA)
IR188_RS16775	COG1473	amidohydrolase
IR188_RS16840	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IR188_RS16855	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IR188_RS16890	COG3727	T/G mismatch-specific endonuclease activity
IR188_RS16895	COG2378	regulation of single-species biofilm formation
IR188_RS16900	COG0625	glutathione transferase activity
IR188_RS16910	COG1396	sequence-specific DNA binding
IR188_RS16915	COG3468	outer membrane autotransporter barrel domain protein
IR188_RS16945	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
IR188_RS16970	COG0582	viral genome integration into host DNA
IR188_RS16980	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IR188_RS16985	COG1690	Belongs to the RtcB family
IR188_RS16990	COG4650	regulator
IR188_RS16995	COG0795	lipopolysaccharide-transporting ATPase activity
IR188_RS17000	COG0795	lipopolysaccharide-transporting ATPase activity
IR188_RS17005	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IR188_RS17010	COG2927	DNA polymerase III (CHI subunit)
IR188_RS17015	COG0525	valine-tRNA ligase activity
IR188_RS17020	COG0456	acetyltransferase
IR188_RS17025	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
IR188_RS17030	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IR188_RS17035	COG0540	Belongs to the ATCase OTCase family
IR188_RS17040	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
IR188_RS17050	COG1309	transcriptional regulator
IR188_RS17060	COG1328	CTP reductase activity
IR188_RS17065	COG0602	queuosine metabolic process
IR188_RS17070	COG3787	Belongs to the UPF0306 family
IR188_RS17085	COG3153	acetyltransferase
IR188_RS17090	COG3154	lipid carrier protein
IR188_RS17095	COG0826	peptidase U32
IR188_RS17100	COG0826	peptidase U32
IR188_RS17125	COG3275	phosphorelay sensor kinase activity
IR188_RS17135	COG0513	Belongs to the DEAD box helicase family
IR188_RS17155	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
IR188_RS17160	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
IR188_RS17165	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
IR188_RS17170	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
IR188_RS17175	COG0195	Participates in both transcription termination and antitermination
IR188_RS17195	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IR188_RS17200	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IR188_RS17205	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IR188_RS17210	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IR188_RS17215	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
IR188_RS17220	COG1534	Rna-binding protein
IR188_RS17230	COG2027	D-alanyl-D-alanine carboxypeptidase
IR188_RS17235	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IR188_RS17240	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IR188_RS17245	COG0261	This protein binds to 23S rRNA in the presence of protein L20
IR188_RS17250	COG0142	geranyltranstransferase activity
IR188_RS17260	COG3423	Transcriptional regulator
IR188_RS17265	COG0039	L-malate dehydrogenase activity
IR188_RS17270	COG1438	arginine binding
IR188_RS17275	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IR188_RS17280	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
IR188_RS17290	COG2105	PFAM AIG2 family protein
IR188_RS17300	COG0729	surface antigen
IR188_RS17305	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IR188_RS17310	COG1253	flavin adenine dinucleotide binding
IR188_RS17320	COG1218	3'(2'),5'-bisphosphate nucleotidase
IR188_RS17325	COG0545	Peptidyl-prolyl cis-trans isomerase
IR188_RS17335	COG0359	binds to the 23S rRNA
IR188_RS17340	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
IR188_RS17345	COG2965	DNA replication, synthesis of RNA primer
IR188_RS17350	COG0360	Binds together with S18 to 16S ribosomal RNA
IR188_RS17355	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IR188_RS17360	COG0557	exoribonuclease II activity
IR188_RS17365	COG1959	2 iron, 2 sulfur cluster binding
IR188_RS17370	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IR188_RS17375	COG0330	HflC and HflK could
IR188_RS17380	COG0330	HflC and HflK could
IR188_RS17385	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IR188_RS17390	COG1923	regulation of RNA biosynthetic process
IR188_RS17400	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
IR188_RS17405	COG0860	N-Acetylmuramoyl-L-alanine amidase
IR188_RS17410	COG0802	atpase or kinase
IR188_RS17415	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IR188_RS17440	COG1162	GTPase activity
IR188_RS17445	COG0688	phosphatidylethanolamine metabolic process
IR188_RS17450	COG3264	Mechanosensitive ion channel
IR188_RS17450	COG1511	domain protein
IR188_RS17455	COG0814	amino acid
IR188_RS17460	COG0561	phosphatase activity
IR188_RS17465	COG2267	carboxylic ester hydrolase activity
IR188_RS17470	COG0514	ATP-dependent DNA helicase (RecQ)
IR188_RS17475	COG2962	Rard protein
IR188_RS17490	COG0210	DNA helicase
IR188_RS17495	COG1011	Hydrolase
IR188_RS17510	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
IR188_RS17520	COG1965	Belongs to the frataxin family
IR188_RS17535	COG1587	Uroporphyrinogen-III synthase
IR188_RS17540	COG2959	enzyme of heme biosynthesis
IR188_RS17545	COG3071	HemY protein
IR188_RS17570	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
IR188_RS17580	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IR188_RS17585	COG2244	polysaccharide biosynthetic process
IR188_RS17590	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IR188_RS17595	COG0456	acetyltransferase
IR188_RS17600	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
IR188_RS17605	COG1088	dTDP-glucose 4,6-dehydratase activity
IR188_RS17610	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
IR188_RS17615	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
IR188_RS17620	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
IR188_RS17625	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IR188_RS17630	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
IR188_RS17635	COG3118	belongs to the thioredoxin family
IR188_RS17640	COG0513	Belongs to the DEAD box helicase family
IR188_RS17645	COG0248	Ppx GppA phosphatase
IR188_RS17650	COG0210	DNA helicase
IR188_RS17655	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
IR188_RS17665	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IR188_RS17670	COG0129	dihydroxy-acid dehydratase activity
IR188_RS17680	COG3978	acetolactate synthase activity
IR188_RS17700	COG3085	chromosome segregation
IR188_RS17705	COG0583	DNA-binding transcription factor activity
IR188_RS17740	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IR188_RS17755	COG0009	L-threonylcarbamoyladenylate synthase
IR188_RS17760	COG0551	DNA topoisomerase type I activity
IR188_RS17765	COG0758	DNA mediated transformation
IR188_RS17770	COG0242	peptide deformylase activity
IR188_RS17775	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IR188_RS17780	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IR188_RS17780	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IR188_RS17785	COG0569	domain protein
IR188_RS17795	COG3036	rescue of stalled ribosome
IR188_RS17800	COG0789	Transcriptional regulator
IR188_RS17815	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
IR188_RS17820	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IR188_RS17825	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
IR188_RS17830	COG0257	Belongs to the bacterial ribosomal protein bL36 family
IR188_RS17835	COG0201	protein transport
IR188_RS17840	COG0200	Binds to the 23S rRNA
IR188_RS17845	COG1841	ribosomal large subunit assembly
IR188_RS17850	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
IR188_RS17860	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
IR188_RS17865	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
IR188_RS17870	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
IR188_RS17880	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
IR188_RS17885	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
IR188_RS17890	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IR188_RS17895	COG0255	Belongs to the universal ribosomal protein uL29 family
IR188_RS17900	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IR188_RS17905	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
IR188_RS17910	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
IR188_RS17915	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
IR188_RS17920	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
IR188_RS17935	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IR188_RS17940	COG0051	transcription antitermination factor activity, RNA binding
IR188_RS17980	COG1072	(Pantothenic acid kinase))
IR188_RS17990	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IR188_RS18025	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
IR188_RS18030	COG4206	TonB-dependent receptor
IR188_RS18035	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IR188_RS18040	COG5266	PFAM Nickel transport complex, NikM subunit, transmembrane
IR188_RS18045	COG0310	cobalt ion transport
IR188_RS18050	COG0310	cobalt ion transport
IR188_RS18060	COG1122	ATPase activity
IR188_RS18065	COG2252	PERMEase
IR188_RS18070	COG0765	amino acid transport
IR188_RS18075	COG0765	amino acid transport
IR188_RS18080	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IR188_RS18090	COG3121	Chaperone
IR188_RS18095	COG3188	usher protein
IR188_RS18115	COG0704	Plays a role in the regulation of phosphate uptake
IR188_RS18125	COG0581	inorganic phosphate transmembrane transporter activity
IR188_RS18130	COG0573	inorganic phosphate transmembrane transporter activity
IR188_RS18135	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
IR188_RS18150	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IR188_RS18155	COG2183	response to ionizing radiation
IR188_RS18160	COG1918	ferrous iron import across plasma membrane
IR188_RS18175	COG2267	carboxylic ester hydrolase activity
IR188_RS18180	COG1040	competence protein
IR188_RS18185	COG0316	Belongs to the HesB IscA family
IR188_RS18185	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
IR188_RS18195	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IR188_RS18200	COG0705	Rhomboid family
IR188_RS18205	COG1349	DNA-binding transcription factor activity
IR188_RS18210	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
IR188_RS18225	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
IR188_RS18230	COG0028	Belongs to the TPP enzyme family
IR188_RS18235	COG1473	amidohydrolase
IR188_RS18240	COG0583	DNA-binding transcription factor activity
IR188_RS18245	COG1396	sequence-specific DNA binding
IR188_RS18250	COG0477	Major facilitator Superfamily
IR188_RS18270	COG0814	amino acid
IR188_RS18275	COG1396	sequence-specific DNA binding
IR188_RS18280	COG0183	Belongs to the thiolase family
IR188_RS18285	COG2031	fatty acid transporter
IR188_RS18290	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
IR188_RS18295	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
IR188_RS18300	COG2204	response regulator
IR188_RS18305	COG3852	Histidine kinase
IR188_RS18310	COG0800	Aldolase
IR188_RS18315	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IR188_RS18320	COG1904	glucuronate isomerase
IR188_RS18325	COG0246	Mannitol dehydrogenase
IR188_RS18340	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
IR188_RS18350	COG2186	Transcriptional regulator
IR188_RS18355	COG0626	cystathionine gamma-synthase activity
IR188_RS18360	COG1757	Na H antiporter
IR188_RS18365	COG2515	1-aminocyclopropane-1-carboxylate deaminase
IR188_RS18375	COG3121	Chaperone
IR188_RS18380	COG3188	usher protein
IR188_RS18395	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IR188_RS18400	COG3162	membrane
IR188_RS18405	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IR188_RS18410	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IR188_RS18415	COG2258	MOSC domain
IR188_RS18425	COG3381	protein complex oligomerization
IR188_RS18430	COG3302	dmso reductase anchor subunit
IR188_RS18435	COG0437	4 iron, 4 sulfur cluster binding
IR188_RS18440	COG0243	molybdopterin cofactor binding
IR188_RS18450	COG0180	Tryptophanyl-tRNA synthetase
IR188_RS18455	COG0546	phosphoglycolate phosphatase activity
IR188_RS18460	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IR188_RS18470	COG3266	domain, Protein
IR188_RS18475	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IR188_RS18485	COG4796	Type ii and iii secretion system protein
IR188_RS18505	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
IR188_RS18510	COG0494	nUDIX hydrolase
IR188_RS18520	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
IR188_RS18525	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
IR188_RS18530	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
IR188_RS18535	COG1741	Belongs to the pirin family
IR188_RS18540	COG2081	HI0933 family
IR188_RS18545	COG0306	phosphate transporter
IR188_RS18555	COG0589	response to stress
IR188_RS18560	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IR188_RS18565	COG0742	ribosomal rna small subunit methyltransferase
IR188_RS18580	COG0582	viral genome integration into host DNA
IR188_RS18620	COG0640	Transcriptional regulator
IR188_RS18700	COG3039	Transposase
IR188_RS18710	COG3436	PFAM IS66 Orf2 family protein
IR188_RS18770	COG4584	PFAM Integrase catalytic
IR188_RS18775	COG1484	DNA-dependent DNA replication
IR188_RS18780	COG3468	outer membrane autotransporter barrel domain protein
IR188_RS18800	COG2003	Belongs to the UPF0758 family
IR188_RS18870	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
IR188_RS18875	COG3683	transport system, periplasmic component
IR188_RS18880	COG0840	transmembrane signaling receptor activity
IR188_RS18885	COG0625	glutathione transferase activity