locus-tag	class	description
HQ865_RS00010	COG3256	nitric oxide reductase
HQ865_RS00015	COG0633	Ferredoxin
HQ865_RS00020	COG0492	ferredoxin-NADP+ reductase activity
HQ865_RS00075	COG1959	2 iron, 2 sulfur cluster binding
HQ865_RS00140	COG4804	nuclease activity
HQ865_RS00155	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HQ865_RS00160	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HQ865_RS00175	COG1388	LysM domain
HQ865_RS00175	COG0791	NLP P60 protein
HQ865_RS00185	COG4122	O-methyltransferase activity
HQ865_RS00190	COG2267	carboxylic ester hydrolase activity
HQ865_RS00200	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HQ865_RS00205	COG0470	DNA polymerase III
HQ865_RS00210	COG1774	PSP1 C-terminal conserved region
HQ865_RS00235	COG0047	phosphoribosylformylglycinamidine synthase activity
HQ865_RS00255	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HQ865_RS00290	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HQ865_RS00295	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HQ865_RS00300	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HQ865_RS00320	COG4771	TonB-dependent receptor
HQ865_RS00325	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HQ865_RS00365	COG0632	four-way junction helicase activity
HQ865_RS00380	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HQ865_RS00415	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HQ865_RS00420	COG0459	protein refolding
HQ865_RS00425	COG0668	transmembrane transport
HQ865_RS00430	COG1760	l-serine dehydratase
HQ865_RS00465	COG0010	Belongs to the arginase family
HQ865_RS00470	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HQ865_RS00475	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HQ865_RS00485	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HQ865_RS00505	COG1216	Glycosyl transferase, family 2
HQ865_RS00515	COG0745	RESPONSE REGULATOR receiver
HQ865_RS00530	COG2755	lipolytic protein G-D-S-L family
HQ865_RS00530	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HQ865_RS00575	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HQ865_RS00590	COG0513	Belongs to the DEAD box helicase family
HQ865_RS00610	COG0148	phosphopyruvate hydratase activity
HQ865_RS00630	COG2197	response regulator
HQ865_RS00640	COG4585	Histidine kinase
HQ865_RS00645	COG4585	Histidine kinase
HQ865_RS00660	COG2972	Histidine kinase
HQ865_RS00685	COG3291	Pkd domain containing protein
HQ865_RS00690	COG3279	Response regulator of the LytR AlgR family
HQ865_RS00695	COG3275	phosphorelay sensor kinase activity
HQ865_RS00770	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HQ865_RS00775	COG2890	protein-(glutamine-N5) methyltransferase activity
HQ865_RS00990	COG4974	Belongs to the 'phage' integrase family
HQ865_RS01045	COG1629	transport
HQ865_RS01045	COG4206	TonB-dependent receptor
HQ865_RS01095	COG4974	Belongs to the 'phage' integrase family
HQ865_RS01530	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HQ865_RS01530	COG0321	lipoyl(octanoyl) transferase activity
HQ865_RS01545	COG1472	Belongs to the glycosyl hydrolase 3 family
HQ865_RS01565	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HQ865_RS01580	COG3250	beta-galactosidase activity
HQ865_RS01585	COG3408	Glycogen debranching enzyme
HQ865_RS01595	COG3250	beta-galactosidase activity
HQ865_RS01600	COG1609	Transcriptional regulator
HQ865_RS01620	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HQ865_RS01625	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HQ865_RS01645	COG4771	TonB-dependent receptor
HQ865_RS01685	COG3250	beta-galactosidase activity
HQ865_RS01690	COG3250	beta-galactosidase activity
HQ865_RS01725	COG0673	inositol 2-dehydrogenase activity
HQ865_RS01730	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HQ865_RS01745	COG3940	Belongs to the glycosyl hydrolase 43 family
HQ865_RS01770	COG0138	bifunctional purine biosynthesis protein purh
HQ865_RS01775	COG1077	Cell shape determining protein MreB Mrl
HQ865_RS01790	COG0768	penicillin binding
HQ865_RS01795	COG0772	Belongs to the SEDS family
HQ865_RS01805	COG1201	RNA secondary structure unwinding
HQ865_RS01820	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HQ865_RS01830	COG0590	tRNA wobble adenosine to inosine editing
HQ865_RS01840	COG1132	(ABC) transporter
HQ865_RS01845	COG0233	cytoplasmic translational termination
HQ865_RS01875	COG3511	phospholipase C
HQ865_RS01885	COG0745	RESPONSE REGULATOR receiver
HQ865_RS01885	COG2205	protein histidine kinase activity
HQ865_RS01885	COG3292	Two component regulator propeller
HQ865_RS01885	COG0745	RESPONSE REGULATOR receiver
HQ865_RS01885	COG2205	protein histidine kinase activity
HQ865_RS01885	COG3292	Two component regulator propeller
HQ865_RS01895	COG4771	TonB-dependent receptor
HQ865_RS01935	COG0702	epimerase
HQ865_RS01940	COG4771	TonB-dependent receptor
HQ865_RS01955	COG3345	alpha-galactosidase
HQ865_RS01985	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HQ865_RS02005	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HQ865_RS02005	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HQ865_RS02040	COG0415	Belongs to the DNA photolyase family
HQ865_RS02050	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HQ865_RS02055	COG1597	lipid kinase activity
HQ865_RS02060	COG0023	Translation Initiation Factor
HQ865_RS02070	COG0484	heat shock protein binding
HQ865_RS02105	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HQ865_RS02115	COG1595	DNA-templated transcription, initiation
HQ865_RS02125	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HQ865_RS02140	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HQ865_RS02145	COG0811	peptide transport
HQ865_RS02175	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HQ865_RS02180	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HQ865_RS02185	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HQ865_RS02190	COG0649	NAD binding
HQ865_RS02195	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
HQ865_RS02205	COG1034	ATP synthesis coupled electron transport
HQ865_RS02210	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HQ865_RS02215	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HQ865_RS02225	COG0713	ATP synthesis coupled electron transport
HQ865_RS02230	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HQ865_RS02235	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HQ865_RS02240	COG1007	ATP synthesis coupled electron transport
HQ865_RS02245	COG0586	Pfam SNARE associated Golgi protein
HQ865_RS02255	COG1253	flavin adenine dinucleotide binding
HQ865_RS02270	COG4770	biotin carboxylase activity
HQ865_RS02285	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HQ865_RS02295	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HQ865_RS02315	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HQ865_RS02320	COG5654	RES domain protein
HQ865_RS02330	COG0006	proline dipeptidase activity
HQ865_RS02345	COG0251	oxidation-reduction process
HQ865_RS02355	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HQ865_RS02375	COG0004	ammonium transporteR
HQ865_RS02450	COG1028	Short-chain dehydrogenase reductase Sdr
HQ865_RS02455	COG2226	methyltransferase
HQ865_RS02490	COG0557	exoribonuclease II activity
HQ865_RS02500	COG2442	InterPro IPR007367
HQ865_RS02505	COG4172	Belongs to the ABC transporter superfamily
HQ865_RS02525	COG0463	Glycosyl transferase, family 2
HQ865_RS02535	COG1754	DNA topoisomerase type I activity
HQ865_RS02535	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HQ865_RS02540	COG0482	sulfurtransferase activity
HQ865_RS02545	COG0714	Associated with various cellular activities
HQ865_RS02605	COG1629	transport
HQ865_RS02605	COG4206	TonB-dependent receptor
HQ865_RS02625	COG0366	Alpha amylase catalytic
HQ865_RS02635	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HQ865_RS02645	COG0484	heat shock protein binding
HQ865_RS02655	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HQ865_RS02665	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HQ865_RS02680	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HQ865_RS02690	COG0137	argininosuccinate synthase activity
HQ865_RS02710	COG2731	YhcH YjgK YiaL family protein
HQ865_RS02720	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HQ865_RS02725	COG0800	Aldolase
HQ865_RS02730	COG2271	Major facilitator Superfamily
HQ865_RS02735	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HQ865_RS02745	COG0745	RESPONSE REGULATOR receiver
HQ865_RS02755	COG0745	RESPONSE REGULATOR receiver
HQ865_RS02760	COG0745	RESPONSE REGULATOR receiver
HQ865_RS02765	COG0492	ferredoxin-NADP+ reductase activity
HQ865_RS02770	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HQ865_RS02790	COG4120	Belongs to the binding-protein-dependent transport system permease family
HQ865_RS02820	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HQ865_RS02835	COG0657	acetylesterase activity
HQ865_RS02835	COG2755	lipolytic protein G-D-S-L family
HQ865_RS02840	COG3279	Response regulator of the LytR AlgR family
HQ865_RS02845	COG2972	Histidine kinase
HQ865_RS02860	COG1070	Carbohydrate kinase
HQ865_RS02865	COG1609	Transcriptional regulator
HQ865_RS02870	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HQ865_RS02890	COG2096	Adenosyltransferase
HQ865_RS02915	COG1228	amidohydrolase
HQ865_RS02925	COG0514	ATP-dependent DNA helicase (RecQ)
HQ865_RS02945	COG2001	Belongs to the MraZ family
HQ865_RS02950	COG0275	rRNA processing
HQ865_RS02965	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HQ865_RS02975	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HQ865_RS02980	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HQ865_RS02985	COG0772	Belongs to the SEDS family
HQ865_RS02990	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HQ865_RS02995	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HQ865_RS03010	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HQ865_RS03015	COG0156	8-amino-7-oxononanoate synthase activity
HQ865_RS03030	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
HQ865_RS03035	COG3119	arylsulfatase activity
HQ865_RS03040	COG1629	transport
HQ865_RS03050	COG3119	arylsulfatase activity
HQ865_RS03065	COG4771	TonB-dependent receptor
HQ865_RS03070	COG0702	epimerase
HQ865_RS03075	COG4771	TonB-dependent receptor
HQ865_RS03120	COG3590	peptidase
HQ865_RS03130	COG3590	peptidase
HQ865_RS03140	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HQ865_RS03145	COG4206	TonB-dependent receptor
HQ865_RS03170	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HQ865_RS03185	COG1408	metallophosphoesterase
HQ865_RS03200	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HQ865_RS03205	COG3258	Cytochrome c
HQ865_RS03245	COG1595	DNA-templated transcription, initiation
HQ865_RS03250	COG3958	Transketolase
HQ865_RS03255	COG3959	Transketolase, thiamine diphosphate binding domain
HQ865_RS03260	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HQ865_RS03270	COG0179	Fumarylacetoacetate (FAA) hydrolase
HQ865_RS03275	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HQ865_RS03290	COG2207	Transcriptional regulator
HQ865_RS03290	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HQ865_RS03310	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HQ865_RS03350	COG0306	phosphate transporter
HQ865_RS03375	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
HQ865_RS03380	COG3959	Transketolase, thiamine diphosphate binding domain
HQ865_RS03385	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HQ865_RS03390	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HQ865_RS03395	COG1028	Short-chain dehydrogenase reductase Sdr
HQ865_RS03405	COG2089	acid synthase
HQ865_RS03415	COG4221	oxidoreductase activity
HQ865_RS03465	COG0673	inositol 2-dehydrogenase activity
HQ865_RS03490	COG0673	inositol 2-dehydrogenase activity
HQ865_RS03505	COG2211	Major facilitator Superfamily
HQ865_RS03530	COG1629	transport
HQ865_RS03535	COG1349	DNA-binding transcription factor activity
HQ865_RS03540	COG2270	Major facilitator Superfamily
HQ865_RS03565	COG1172	Belongs to the binding-protein-dependent transport system permease family
HQ865_RS03570	COG1129	ABC transporter
HQ865_RS03585	COG3958	Transketolase
HQ865_RS03590	COG3959	Transketolase, thiamine diphosphate binding domain
HQ865_RS03615	COG1850	ribulose-bisphosphate carboxylase activity
HQ865_RS03620	COG0738	Major facilitator superfamily
HQ865_RS03640	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HQ865_RS03660	COG0501	Belongs to the peptidase M48B family
HQ865_RS03675	COG0247	lactate metabolic process
HQ865_RS03680	COG1139	Iron-sulfur cluster binding protein
HQ865_RS03685	COG1556	Lactate utilization protein
HQ865_RS03695	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HQ865_RS03700	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HQ865_RS03725	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HQ865_RS03745	COG2197	response regulator
HQ865_RS03765	COG2207	Transcriptional regulator
HQ865_RS03775	COG3158	transport of potassium into the cell
HQ865_RS03820	COG0640	Transcriptional regulator
HQ865_RS03825	COG4771	TonB-dependent receptor
HQ865_RS03830	COG0702	epimerase
HQ865_RS03850	COG1472	Belongs to the glycosyl hydrolase 3 family
HQ865_RS03855	COG1028	Short-chain dehydrogenase reductase Sdr
HQ865_RS03890	COG1595	DNA-templated transcription, initiation
HQ865_RS03905	COG0450	alkyl hydroperoxide reductase
HQ865_RS03925	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
HQ865_RS03930	COG1028	Short-chain dehydrogenase reductase Sdr
HQ865_RS03940	COG0746	molybdenum cofactor guanylyltransferase activity
HQ865_RS03945	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HQ865_RS03950	COG0626	cystathionine gamma-synthase activity
HQ865_RS03955	COG0531	amino acid
HQ865_RS03990	COG0681	Belongs to the peptidase S26 family
HQ865_RS03995	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HQ865_RS04005	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HQ865_RS04030	COG0156	8-amino-7-oxononanoate synthase activity
HQ865_RS04035	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HQ865_RS04055	COG0702	epimerase
HQ865_RS04060	COG4771	TonB-dependent receptor
HQ865_RS04065	COG1250	3-hydroxyacyl-CoA dehydrogenase
HQ865_RS04080	COG0179	Fumarylacetoacetate (FAA) hydrolase
HQ865_RS04085	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HQ865_RS04090	COG3185	4-Hydroxyphenylpyruvate dioxygenase
HQ865_RS04110	COG2226	methyltransferase
HQ865_RS04125	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
HQ865_RS04145	COG3250	beta-galactosidase activity
HQ865_RS04155	COG0360	Binds together with S18 to 16S ribosomal RNA
HQ865_RS04160	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HQ865_RS04165	COG0359	binds to the 23S rRNA
HQ865_RS04225	COG0247	lactate metabolic process
HQ865_RS04225	COG2181	nitrate reductase activity
HQ865_RS04235	COG0247	lactate metabolic process
HQ865_RS04235	COG2181	nitrate reductase activity
HQ865_RS04295	COG0280	phosphate acetyltransferase
HQ865_RS04295	COG0281	malic enzyme
HQ865_RS04305	COG2824	Alkylphosphonate utilization operon protein PhnA
HQ865_RS04315	COG3040	lipid binding
HQ865_RS04330	COG4771	TonB-dependent receptor
HQ865_RS04355	COG3537	Alpha-1,2-mannosidase
HQ865_RS04370	COG1472	Belongs to the glycosyl hydrolase 3 family
HQ865_RS04395	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HQ865_RS04405	COG2382	esterase
HQ865_RS04415	COG4771	TonB-dependent receptor
HQ865_RS04425	COG0745	RESPONSE REGULATOR receiver
HQ865_RS04425	COG2205	protein histidine kinase activity
HQ865_RS04425	COG3292	Two component regulator propeller
HQ865_RS04435	COG1619	proteins homologs of microcin C7 resistance protein MccF
HQ865_RS04465	COG0784	Response regulator, receiver
HQ865_RS04465	COG2205	protein histidine kinase activity
HQ865_RS04505	COG1022	Amp-dependent synthetase and ligase
HQ865_RS04525	COG0506	proline dehydrogenase activity
HQ865_RS04525	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HQ865_RS04525	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HQ865_RS04530	COG0288	reversible hydration of carbon dioxide
HQ865_RS04545	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HQ865_RS04550	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HQ865_RS04555	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HQ865_RS04560	COG0288	reversible hydration of carbon dioxide
HQ865_RS04575	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HQ865_RS04620	COG0051	transcription antitermination factor activity, RNA binding
HQ865_RS04625	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HQ865_RS04630	COG0049	tRNA binding
HQ865_RS04635	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HQ865_RS04645	COG1196	nuclear chromosome segregation
HQ865_RS04665	COG1970	mechanosensitive ion channel activity
HQ865_RS04710	COG1136	(ABC) transporter
HQ865_RS04735	COG1196	nuclear chromosome segregation
HQ865_RS04740	COG0436	Aminotransferase
HQ865_RS04760	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HQ865_RS04780	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HQ865_RS04785	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HQ865_RS04790	COG2226	methyltransferase
HQ865_RS04800	COG4221	oxidoreductase activity
HQ865_RS04805	COG1610	YqeY-like protein
HQ865_RS04820	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HQ865_RS04845	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HQ865_RS04850	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HQ865_RS04865	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HQ865_RS04885	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HQ865_RS04890	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HQ865_RS04895	COG0839	Belongs to the complex I subunit 6 family
HQ865_RS04900	COG0713	ATP synthesis coupled electron transport
HQ865_RS04910	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HQ865_RS04920	COG1007	ATP synthesis coupled electron transport
HQ865_RS04925	COG0004	ammonium transporteR
HQ865_RS04975	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HQ865_RS04985	COG0564	pseudouridine synthase activity
HQ865_RS05005	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HQ865_RS05010	COG3876	Protein conserved in bacteria
HQ865_RS05015	COG4591	ABC-type transport system involved in lipoprotein release permease component
HQ865_RS05025	COG1595	DNA-templated transcription, initiation
HQ865_RS05035	COG3956	TIGRFAM MazG family protein
HQ865_RS05100	COG0667	Aldo Keto reductase
HQ865_RS05140	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HQ865_RS05145	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HQ865_RS05150	COG2226	methyltransferase
HQ865_RS05155	COG0473	3-isopropylmalate dehydrogenase activity
HQ865_RS05160	COG0066	3-isopropylmalate dehydratase activity
HQ865_RS05170	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HQ865_RS05175	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HQ865_RS05180	COG0440	acetolactate synthase activity
HQ865_RS05185	COG0028	Belongs to the TPP enzyme family
HQ865_RS05195	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HQ865_RS05210	COG1309	transcriptional regulator
HQ865_RS05220	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HQ865_RS05275	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HQ865_RS05280	COG1984	allophanate hydrolase subunit 2
HQ865_RS05285	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HQ865_RS05290	COG1914	H( )-stimulated, divalent metal cation uptake system
HQ865_RS05310	COG1629	transport
HQ865_RS05310	COG4206	TonB-dependent receptor
HQ865_RS05335	COG4977	sequence-specific DNA binding
HQ865_RS05340	COG5492	domain, Protein
HQ865_RS05350	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
HQ865_RS05365	COG4771	TonB-dependent receptor
HQ865_RS05410	COG1595	DNA-templated transcription, initiation
HQ865_RS05420	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HQ865_RS05430	COG0302	gtp cyclohydrolase
HQ865_RS05435	COG2270	Major facilitator Superfamily
HQ865_RS05440	COG0247	lactate metabolic process
HQ865_RS05460	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HQ865_RS05465	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HQ865_RS05470	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HQ865_RS05475	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HQ865_RS05480	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HQ865_RS05490	COG1119	ATPase activity
HQ865_RS05510	COG2723	6-phospho-beta-galactosidase activity
HQ865_RS05515	COG2205	protein histidine kinase activity
HQ865_RS05520	COG1960	acyl-CoA dehydrogenase activity
HQ865_RS05530	COG0277	FAD linked oxidase domain protein
HQ865_RS05540	COG0071	Belongs to the small heat shock protein (HSP20) family
HQ865_RS05550	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HQ865_RS05555	COG1506	peptidase
HQ865_RS05555	COG0823	Involved in the tonB-independent uptake of proteins
HQ865_RS05590	COG0300	oxidoreductase activity
HQ865_RS05600	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HQ865_RS05605	COG1127	ABC transporter
HQ865_RS05610	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HQ865_RS05610	COG0116	Belongs to the methyltransferase superfamily
HQ865_RS05635	COG2197	response regulator
HQ865_RS05645	COG0542	response to heat
HQ865_RS05660	COG0488	(ABC) transporter
HQ865_RS05675	COG3590	peptidase
HQ865_RS05685	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HQ865_RS05695	COG1666	GTP binding
HQ865_RS05710	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HQ865_RS05730	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HQ865_RS05735	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HQ865_RS05745	COG0483	inositol monophosphate 1-phosphatase activity
HQ865_RS05770	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HQ865_RS05775	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HQ865_RS05785	COG1028	Short-chain dehydrogenase reductase Sdr
HQ865_RS05785	COG3321	synthase
HQ865_RS05785	COG0604	alcohol dehydrogenase
HQ865_RS05805	COG0563	adenylate kinase activity
HQ865_RS05810	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HQ865_RS05815	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HQ865_RS05835	COG0572	uridine kinase
HQ865_RS05850	COG0783	Belongs to the Dps family
HQ865_RS05865	COG0442	prolyl-tRNA aminoacylation
HQ865_RS05875	COG0626	cystathionine gamma-synthase activity
HQ865_RS05895	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HQ865_RS05950	COG2095	MarC family integral membrane protein
HQ865_RS05955	COG0531	amino acid
HQ865_RS05960	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HQ865_RS05965	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HQ865_RS05975	COG1301	dicarboxylic acid transport
HQ865_RS06015	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HQ865_RS06020	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HQ865_RS06040	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HQ865_RS06055	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HQ865_RS06065	COG3250	beta-galactosidase activity
HQ865_RS06105	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HQ865_RS06135	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HQ865_RS06140	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HQ865_RS06155	COG0735	belongs to the Fur family
HQ865_RS06160	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HQ865_RS06170	COG0386	Belongs to the glutathione peroxidase family
HQ865_RS06195	COG1595	DNA-templated transcription, initiation
HQ865_RS06230	COG0393	Putative heavy-metal-binding
HQ865_RS06245	COG1629	transport
HQ865_RS06265	COG1215	transferase activity, transferring glycosyl groups
HQ865_RS06275	COG2755	lipolytic protein G-D-S-L family
HQ865_RS06275	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HQ865_RS06295	COG4804	nuclease activity
HQ865_RS06315	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HQ865_RS06325	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HQ865_RS06325	COG0517	IMP dehydrogenase activity
HQ865_RS06330	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HQ865_RS06350	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HQ865_RS06360	COG1028	Short-chain dehydrogenase reductase Sdr
HQ865_RS06365	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HQ865_RS06375	COG2089	acid synthase
HQ865_RS06380	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HQ865_RS06385	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HQ865_RS06395	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HQ865_RS06400	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HQ865_RS06430	COG0438	transferase activity, transferring glycosyl groups
HQ865_RS06450	COG1216	Glycosyl transferase, family 2
HQ865_RS06455	COG1090	epimerase
HQ865_RS06475	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HQ865_RS06475	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HQ865_RS06485	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HQ865_RS06515	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
HQ865_RS06530	COG3757	hydrolase, family 25
HQ865_RS06555	COG4895	conserved protein (DUF2196)
HQ865_RS06560	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HQ865_RS06565	COG0165	Argininosuccinate lyase
HQ865_RS06575	COG0488	(ABC) transporter
HQ865_RS06590	COG0167	dihydroorotate dehydrogenase activity
HQ865_RS06605	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HQ865_RS06615	COG0488	(ABC) transporter
HQ865_RS06620	COG5002	protein histidine kinase activity
HQ865_RS06630	COG1959	2 iron, 2 sulfur cluster binding
HQ865_RS06635	COG3250	beta-galactosidase activity
HQ865_RS06645	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HQ865_RS06655	COG2514	catechol 2,3-dioxygenase activity
HQ865_RS06670	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HQ865_RS06685	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HQ865_RS06690	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HQ865_RS06690	COG1648	precorrin-2 dehydrogenase activity
HQ865_RS06695	COG0730	response to heat
HQ865_RS06700	COG0175	sulfate reduction
HQ865_RS06705	COG0175	sulfate reduction
HQ865_RS06725	COG2814	Major facilitator Superfamily
HQ865_RS06735	COG1185	polyribonucleotide nucleotidyltransferase activity
HQ865_RS06740	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HQ865_RS06755	COG3852	Histidine kinase
HQ865_RS06760	COG0477	Major facilitator Superfamily
HQ865_RS06785	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HQ865_RS06785	COG0574	Belongs to the PEP-utilizing enzyme family
HQ865_RS06790	COG0497	DNA recombination
HQ865_RS06800	COG3682	Transcriptional regulator
HQ865_RS06825	COG0484	heat shock protein binding
HQ865_RS06830	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HQ865_RS06845	COG0018	arginyl-trna synthetase
HQ865_RS06855	COG1733	regulation of RNA biosynthetic process
HQ865_RS06860	COG1028	Short-chain dehydrogenase reductase Sdr
HQ865_RS06870	COG0140	phosphoribosyl-ATP diphosphatase activity
HQ865_RS06870	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HQ865_RS06880	COG0107	imidazoleglycerol-phosphate synthase activity
HQ865_RS06885	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HQ865_RS06890	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HQ865_RS06895	COG0131	Imidazoleglycerol-phosphate dehydratase
HQ865_RS06900	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HQ865_RS06905	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HQ865_RS06910	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HQ865_RS06915	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HQ865_RS06925	COG2311	Membrane
HQ865_RS06940	COG0538	isocitrate dehydrogenase activity
HQ865_RS06960	COG1482	cell wall glycoprotein biosynthetic process
HQ865_RS06970	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HQ865_RS07005	COG1609	Transcriptional regulator
HQ865_RS07010	COG1960	acyl-CoA dehydrogenase activity
HQ865_RS07015	COG2086	electron transfer activity
HQ865_RS07020	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HQ865_RS07040	COG1250	3-hydroxyacyl-CoA dehydrogenase
HQ865_RS07040	COG1024	Enoyl-CoA hydratase
HQ865_RS07045	COG0183	Belongs to the thiolase family
HQ865_RS07050	COG1022	Amp-dependent synthetase and ligase
HQ865_RS07060	COG1028	Short-chain dehydrogenase reductase Sdr
HQ865_RS07065	COG3408	Glycogen debranching enzyme
HQ865_RS07080	COG4771	TonB-dependent receptor
HQ865_RS07085	COG0745	RESPONSE REGULATOR receiver
HQ865_RS07085	COG2205	protein histidine kinase activity
HQ865_RS07085	COG3292	Two component regulator propeller
HQ865_RS07085	COG3292	Two component regulator propeller
HQ865_RS07085	COG0745	RESPONSE REGULATOR receiver
HQ865_RS07085	COG2205	protein histidine kinase activity
HQ865_RS07100	COG3250	beta-galactosidase activity
HQ865_RS07120	COG1247	-acetyltransferase
HQ865_RS07145	COG2353	YceI-like domain
HQ865_RS07150	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HQ865_RS07160	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HQ865_RS07165	COG0488	(ABC) transporter
HQ865_RS07180	COG0488	(ABC) transporter
HQ865_RS07185	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HQ865_RS07190	COG0515	serine threonine protein kinase
HQ865_RS07190	COG2815	serine threonine protein kinase
HQ865_RS07200	COG0631	protein serine/threonine phosphatase activity
HQ865_RS07205	COG0772	Belongs to the SEDS family
HQ865_RS07225	COG4953	penicillin-binding protein 1C
HQ865_RS07230	COG2373	Large extracellular alpha-helical protein
HQ865_RS07250	COG0484	heat shock protein binding
HQ865_RS07255	COG0577	efflux transmembrane transporter activity
HQ865_RS07255	COG1136	(ABC) transporter
HQ865_RS07260	COG1136	(ABC) transporter
HQ865_RS07280	COG1629	transport
HQ865_RS07280	COG4206	TonB-dependent receptor
HQ865_RS07300	COG0579	oxidoreductase
HQ865_RS07305	COG1609	Transcriptional regulator
HQ865_RS07310	COG4771	TonB-dependent receptor
HQ865_RS07315	COG0702	epimerase
HQ865_RS07325	COG2755	lipolytic protein G-D-S-L family
HQ865_RS07345	COG0246	Mannitol dehydrogenase
HQ865_RS07350	COG2721	sulfolactate sulfo-lyase activity
HQ865_RS07355	COG0174	glutamine synthetase
HQ865_RS07390	COG1011	Hydrolase
HQ865_RS07410	COG0784	Response regulator, receiver
HQ865_RS07410	COG2205	protein histidine kinase activity
HQ865_RS07415	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HQ865_RS07425	COG2205	protein histidine kinase activity
HQ865_RS07425	COG0784	Response regulator, receiver
HQ865_RS07430	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HQ865_RS07455	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HQ865_RS07485	COG0633	Ferredoxin
HQ865_RS07495	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HQ865_RS07500	COG0424	maF-like protein
HQ865_RS07520	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HQ865_RS07560	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HQ865_RS07575	COG2255	four-way junction helicase activity
HQ865_RS07580	COG0463	Glycosyl transferase, family 2
HQ865_RS07585	COG3104	oligopeptide transport
HQ865_RS07595	COG0183	Belongs to the thiolase family
HQ865_RS07610	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HQ865_RS07615	COG0706	membrane insertase activity
HQ865_RS07620	COG0504	CTP synthase activity
HQ865_RS07630	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HQ865_RS07635	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HQ865_RS07640	COG1428	Deoxynucleoside kinase
HQ865_RS07645	COG0180	Tryptophanyl-tRNA synthetase
HQ865_RS07665	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HQ865_RS07670	COG1136	(ABC) transporter
HQ865_RS07695	COG0745	RESPONSE REGULATOR receiver
HQ865_RS07700	COG5002	protein histidine kinase activity
HQ865_RS07700	COG3850	Histidine kinase
HQ865_RS07710	COG3781	membrane
HQ865_RS07720	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HQ865_RS07730	COG0366	Alpha amylase catalytic
HQ865_RS07760	COG0069	glutamate synthase activity
HQ865_RS07760	COG0067	glutamate synthase
HQ865_RS07760	COG0070	glutamate synthase
HQ865_RS07800	COG0667	Aldo Keto reductase
HQ865_RS07815	COG0544	peptidyl-prolyl cis-trans isomerase activity
HQ865_RS07825	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HQ865_RS07830	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HQ865_RS07840	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HQ865_RS07850	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HQ865_RS07855	COG0077	Prephenate dehydratase
HQ865_RS07855	COG1605	Chorismate mutase
HQ865_RS07860	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HQ865_RS07890	COG0784	Response regulator, receiver
HQ865_RS07890	COG5002	protein histidine kinase activity
HQ865_RS07890	COG2205	protein histidine kinase activity
HQ865_RS07905	COG5002	protein histidine kinase activity
HQ865_RS07940	COG0791	NLP P60 protein
HQ865_RS07945	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HQ865_RS07960	COG2884	Cell division ATP-binding protein ftsE
HQ865_RS07965	COG1309	transcriptional regulator
HQ865_RS07970	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
HQ865_RS07975	COG2814	Major facilitator Superfamily
HQ865_RS07980	COG0527	aspartate kinase activity
HQ865_RS08000	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HQ865_RS08010	COG1193	negative regulation of DNA recombination
HQ865_RS08015	COG2910	NAD(P)H-binding
HQ865_RS08035	COG0519	Catalyzes the synthesis of GMP from XMP
HQ865_RS08035	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HQ865_RS08045	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HQ865_RS08045	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HQ865_RS08060	COG0667	Aldo Keto reductase
HQ865_RS08065	COG0673	inositol 2-dehydrogenase activity
HQ865_RS08080	COG0110	maltose O-acetyltransferase activity
HQ865_RS08085	COG0813	purine-nucleoside phosphorylase activity
HQ865_RS08090	COG0628	permease
HQ865_RS08110	COG0285	dihydrofolate synthase activity
HQ865_RS08300	COG3507	Belongs to the glycosyl hydrolase 43 family
HQ865_RS08310	COG4771	TonB-dependent receptor
HQ865_RS08315	COG0702	epimerase
HQ865_RS08330	COG4771	TonB-dependent receptor
HQ865_RS08340	COG3250	beta-galactosidase activity
HQ865_RS08345	COG3401	FG-GAP repeat protein
HQ865_RS08350	COG3401	FG-GAP repeat protein
HQ865_RS08355	COG3507	Belongs to the glycosyl hydrolase 43 family
HQ865_RS08390	COG1028	Short-chain dehydrogenase reductase Sdr
HQ865_RS08390	COG3347	Dehydrogenase
HQ865_RS08395	COG3254	rhamnose metabolic process
HQ865_RS08400	COG4952	isomerase
HQ865_RS08420	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HQ865_RS08455	COG4413	Urea transporter
HQ865_RS08460	COG0019	diaminopimelate decarboxylase activity
HQ865_RS08465	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HQ865_RS08480	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HQ865_RS08480	COG2755	lipolytic protein G-D-S-L family
HQ865_RS08485	COG3279	Response regulator of the LytR AlgR family
HQ865_RS08490	COG2972	Histidine kinase
HQ865_RS08520	COG1247	-acetyltransferase
HQ865_RS08560	COG0823	Involved in the tonB-independent uptake of proteins
HQ865_RS08560	COG1506	peptidase
HQ865_RS08565	COG0700	Nucleoside recognition
HQ865_RS08585	COG0598	Magnesium transport protein CorA
HQ865_RS08605	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
HQ865_RS08605	COG3264	Mechanosensitive ion channel
HQ865_RS08610	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HQ865_RS08615	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HQ865_RS08620	COG4974	Belongs to the 'phage' integrase family
HQ865_RS08625	COG2890	protein-(glutamine-N5) methyltransferase activity
HQ865_RS08630	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HQ865_RS08630	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HQ865_RS08635	COG0697	spore germination
HQ865_RS08640	COG1739	Uncharacterized protein family UPF0029
HQ865_RS08650	COG2239	Acts as a magnesium transporter
HQ865_RS08655	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HQ865_RS08660	COG0443	Heat shock 70 kDa protein
HQ865_RS08670	COG3142	Participates in the control of copper homeostasis
HQ865_RS08675	COG1446	asparaginase
HQ865_RS08680	COG2378	regulation of single-species biofilm formation
HQ865_RS08685	COG1794	racemase activity, acting on amino acids and derivatives
HQ865_RS08690	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HQ865_RS08695	COG0492	ferredoxin-NADP+ reductase activity
HQ865_RS08705	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HQ865_RS08715	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HQ865_RS08720	COG0019	diaminopimelate decarboxylase activity
HQ865_RS08750	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HQ865_RS08775	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HQ865_RS08775	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HQ865_RS08790	COG1360	Flagellar Motor Protein
HQ865_RS08815	COG0577	efflux transmembrane transporter activity
HQ865_RS08825	COG0577	efflux transmembrane transporter activity
HQ865_RS08830	COG1136	(ABC) transporter
HQ865_RS08830	COG0577	efflux transmembrane transporter activity
HQ865_RS08835	COG0577	efflux transmembrane transporter activity
HQ865_RS08840	COG1136	(ABC) transporter
HQ865_RS08840	COG0577	efflux transmembrane transporter activity
HQ865_RS08860	COG2211	Major facilitator Superfamily
HQ865_RS08880	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HQ865_RS08930	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HQ865_RS08935	COG2086	electron transfer activity
HQ865_RS08945	COG2059	Chromate
HQ865_RS08970	COG0305	Participates in initiation and elongation during chromosome replication
HQ865_RS08990	COG0514	ATP-dependent DNA helicase (RecQ)
HQ865_RS09000	COG0602	queuosine metabolic process
HQ865_RS09020	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HQ865_RS09030	COG0481	GTPase activity
HQ865_RS09050	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HQ865_RS09055	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HQ865_RS09065	COG1501	Belongs to the glycosyl hydrolase 31 family
HQ865_RS09075	COG4206	TonB-dependent receptor
HQ865_RS09075	COG1629	transport
HQ865_RS09085	COG4771	TonB-dependent receptor
HQ865_RS09120	COG1309	transcriptional regulator
HQ865_RS09130	COG2814	Major facilitator Superfamily
HQ865_RS09135	COG1132	(ABC) transporter
HQ865_RS09185	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HQ865_RS09210	COG1442	glycosyl transferase family 8
HQ865_RS09210	COG1216	Glycosyl transferase, family 2
HQ865_RS09230	COG0463	Glycosyl transferase, family 2
HQ865_RS09270	COG3940	Belongs to the glycosyl hydrolase 43 family
HQ865_RS09285	COG1136	(ABC) transporter
HQ865_RS09285	COG0577	efflux transmembrane transporter activity
HQ865_RS09295	COG1289	transmembrane transporter activity
HQ865_RS09300	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HQ865_RS09340	COG0408	coproporphyrinogen oxidase activity
HQ865_RS09345	COG2814	Major facilitator Superfamily
HQ865_RS09350	COG1278	Cold shock
HQ865_RS09360	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
HQ865_RS09365	COG0588	phosphoglycerate mutase activity
HQ865_RS09370	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HQ865_RS09380	COG0626	cystathionine gamma-synthase activity
HQ865_RS09385	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HQ865_RS09390	COG0460	homoserine dehydrogenase
HQ865_RS09400	COG0463	Glycosyl transferase, family 2
HQ865_RS09405	COG0726	polysaccharide deacetylase
HQ865_RS09410	COG0508	dehydrogenase complex catalyzes the overall conversion of
HQ865_RS09415	COG1058	Belongs to the CinA family
HQ865_RS09415	COG1546	Belongs to the CinA family
HQ865_RS09455	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HQ865_RS09460	COG1702	phosphate starvation-inducible protein PhoH
HQ865_RS09475	COG1132	(ABC) transporter
HQ865_RS09485	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HQ865_RS09490	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HQ865_RS09530	COG2808	Putative FMN-binding domain
HQ865_RS09540	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HQ865_RS09550	COG0667	Aldo Keto reductase
HQ865_RS09580	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HQ865_RS09610	COG0667	Aldo Keto reductase
HQ865_RS09625	COG0307	riboflavin synthase, alpha
HQ865_RS09640	COG0439	Biotin carboxylase
HQ865_RS09650	COG4152	abc transporter atp-binding protein
HQ865_RS09655	COG1668	transmembrane transport
HQ865_RS09660	COG0248	Ppx GppA phosphatase
HQ865_RS09700	COG4771	TonB-dependent receptor
HQ865_RS09720	COG1999	signal sequence binding
HQ865_RS09770	COG0588	phosphoglycerate mutase activity
HQ865_RS09775	COG1584	GPR1 FUN34 yaaH family protein
HQ865_RS09785	COG2205	protein histidine kinase activity
HQ865_RS09790	COG1607	acyl-coa hydrolase
HQ865_RS09815	COG1131	(ABC) transporter
HQ865_RS09825	COG1506	peptidase
HQ865_RS09875	COG2217	Heavy metal translocating P-type atpase
HQ865_RS09880	COG0328	RNA-DNA hybrid ribonuclease activity
HQ865_RS09885	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HQ865_RS09895	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HQ865_RS09900	COG0346	lactoylglutathione lyase activity
HQ865_RS09905	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HQ865_RS09920	COG0123	including yeast histone deacetylase and acetoin utilization protein
HQ865_RS09925	COG3844	kynureninase activity
HQ865_RS09930	COG2094	Belongs to the DNA glycosylase MPG family
HQ865_RS09940	COG1956	GAF domain-containing protein
HQ865_RS09960	COG1028	Short-chain dehydrogenase reductase Sdr
HQ865_RS09965	COG1309	transcriptional regulator
HQ865_RS09970	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HQ865_RS09975	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HQ865_RS09995	COG0513	Belongs to the DEAD box helicase family
HQ865_RS10005	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HQ865_RS10020	COG0517	IMP dehydrogenase activity
HQ865_RS10020	COG0516	GMP reductase activity
HQ865_RS10040	COG0612	Peptidase, M16
HQ865_RS10055	COG0577	efflux transmembrane transporter activity
HQ865_RS10055	COG1136	(ABC) transporter
HQ865_RS10060	COG0577	efflux transmembrane transporter activity
HQ865_RS10060	COG1136	(ABC) transporter
HQ865_RS10070	COG0577	efflux transmembrane transporter activity
HQ865_RS10075	COG0577	efflux transmembrane transporter activity
HQ865_RS10080	COG0577	efflux transmembrane transporter activity
HQ865_RS10090	COG0577	efflux transmembrane transporter activity
HQ865_RS10100	COG1136	(ABC) transporter
HQ865_RS10100	COG0577	efflux transmembrane transporter activity
HQ865_RS10115	COG3852	Histidine kinase
HQ865_RS10125	COG4628	conserved protein (DUF2132)
HQ865_RS10140	COG0326	Molecular chaperone. Has ATPase activity
HQ865_RS10150	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HQ865_RS10175	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HQ865_RS10185	COG1331	Highly conserved protein containing a thioredoxin domain
HQ865_RS10190	COG3549	Plasmid maintenance system killer
HQ865_RS10215	COG3620	sequence-specific DNA binding
HQ865_RS10250	COG2755	lipolytic protein G-D-S-L family
HQ865_RS10255	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HQ865_RS10260	COG4948	Mandelate Racemase Muconate Lactonizing
HQ865_RS10270	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HQ865_RS10275	COG2885	chlorophyll binding
HQ865_RS10285	COG1765	OsmC-like protein
HQ865_RS10295	COG1252	NADH dehydrogenase
HQ865_RS10300	COG0596	Alpha beta hydrolase
HQ865_RS10315	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HQ865_RS10325	COG0527	aspartate kinase activity
HQ865_RS10345	COG1764	response to oxidative stress
HQ865_RS10355	COG0531	amino acid
HQ865_RS10365	COG2223	nitrite transmembrane transporter activity
HQ865_RS10410	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HQ865_RS10445	COG0640	Transcriptional regulator
HQ865_RS10465	COG0784	Response regulator, receiver
HQ865_RS10465	COG2198	Histidine kinase
HQ865_RS10465	COG5002	protein histidine kinase activity
HQ865_RS10470	COG0513	Belongs to the DEAD box helicase family
HQ865_RS10515	COG0784	Response regulator, receiver
HQ865_RS10515	COG2205	protein histidine kinase activity
HQ865_RS10520	COG3664	PFAM glycoside hydrolase family 39
HQ865_RS10555	COG2755	lipolytic protein G-D-S-L family
HQ865_RS10565	COG2755	lipolytic protein G-D-S-L family
HQ865_RS10570	COG3250	beta-galactosidase activity
HQ865_RS10590	COG2755	lipolytic protein G-D-S-L family
HQ865_RS10595	COG0784	Response regulator, receiver
HQ865_RS10595	COG2205	protein histidine kinase activity
HQ865_RS10615	COG1278	Cold shock
HQ865_RS10625	COG4206	TonB-dependent receptor
HQ865_RS10625	COG1629	transport
HQ865_RS10645	COG2081	HI0933 family
HQ865_RS10650	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HQ865_RS10655	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HQ865_RS10670	COG0473	3-isopropylmalate dehydrogenase activity
HQ865_RS10675	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HQ865_RS10690	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HQ865_RS10695	COG1678	Uncharacterized ACR, COG1678
HQ865_RS10700	COG0259	pyridoxamine-phosphate oxidase activity
HQ865_RS10705	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HQ865_RS10715	COG0649	NAD binding
HQ865_RS10730	COG0004	ammonium transporteR
HQ865_RS10745	COG2989	Protein conserved in bacteria
HQ865_RS10760	COG0022	dehydrogenase e1 component
HQ865_RS10770	COG0436	Aminotransferase
HQ865_RS10875	COG3511	phospholipase C
HQ865_RS10880	COG1629	transport
HQ865_RS10920	COG4771	TonB-dependent receptor
HQ865_RS10970	COG5002	protein histidine kinase activity
HQ865_RS10975	COG2205	protein histidine kinase activity
HQ865_RS10985	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HQ865_RS10995	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HQ865_RS11005	COG2204	response regulator
HQ865_RS11015	COG5002	protein histidine kinase activity
HQ865_RS11015	COG0784	Response regulator, receiver
HQ865_RS11050	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HQ865_RS11055	COG1278	Cold shock
HQ865_RS11120	COG0438	transferase activity, transferring glycosyl groups
HQ865_RS11125	COG4974	Belongs to the 'phage' integrase family
HQ865_RS11205	COG4206	TonB-dependent receptor
HQ865_RS11205	COG1629	transport
HQ865_RS11270	COG4974	Belongs to the 'phage' integrase family
HQ865_RS11355	COG2205	protein histidine kinase activity
HQ865_RS11360	COG2204	response regulator
HQ865_RS11370	COG0577	efflux transmembrane transporter activity
HQ865_RS11375	COG1136	(ABC) transporter
HQ865_RS11410	COG2205	protein histidine kinase activity
HQ865_RS11415	COG0745	RESPONSE REGULATOR receiver
HQ865_RS11415	COG2205	protein histidine kinase activity
HQ865_RS11415	COG3292	Two component regulator propeller
HQ865_RS11425	COG2354	Protein conserved in bacteria
HQ865_RS11430	COG0702	epimerase
HQ865_RS11435	COG4771	TonB-dependent receptor
HQ865_RS11450	COG4682	membrane
HQ865_RS11490	COG4974	Belongs to the 'phage' integrase family
HQ865_RS11580	COG0205	6-phosphofructokinase activity
HQ865_RS11590	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HQ865_RS11600	COG0577	efflux transmembrane transporter activity
HQ865_RS11615	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HQ865_RS11620	COG0750	zinc metalloprotease
HQ865_RS11625	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HQ865_RS11645	COG1216	Glycosyl transferase, family 2
HQ865_RS11650	COG0463	Glycosyl transferase, family 2
HQ865_RS11675	COG0542	response to heat
HQ865_RS11680	COG5002	protein histidine kinase activity
HQ865_RS11690	COG0401	homolog of Blt101
HQ865_RS11695	COG1741	Belongs to the pirin family
HQ865_RS11765	COG3189	MarR family transcriptional regulator
HQ865_RS11775	COG4773	Receptor
HQ865_RS11785	COG1063	alcohol dehydrogenase
HQ865_RS11790	COG0667	Aldo Keto reductase
HQ865_RS11810	COG2235	arginine
HQ865_RS11820	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HQ865_RS11855	COG0126	phosphoglycerate kinase activity
HQ865_RS11870	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HQ865_RS11875	COG1215	transferase activity, transferring glycosyl groups
HQ865_RS11885	COG0489	protein tyrosine kinase activity
HQ865_RS11895	COG0367	asparagine synthase
HQ865_RS11925	COG1215	transferase activity, transferring glycosyl groups
HQ865_RS11935	COG0438	transferase activity, transferring glycosyl groups
HQ865_RS11970	COG0463	Glycosyl transferase, family 2
HQ865_RS11980	COG1216	Glycosyl transferase, family 2
HQ865_RS11990	COG0438	transferase activity, transferring glycosyl groups
HQ865_RS12010	COG0438	transferase activity, transferring glycosyl groups
HQ865_RS12020	COG0297	glycogen (starch) synthase activity
HQ865_RS12025	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HQ865_RS12080	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HQ865_RS12085	COG0159	tryptophan synthase activity
HQ865_RS12090	COG0133	tryptophan synthase activity
HQ865_RS12095	COG0135	phosphoribosylanthranilate isomerase activity
HQ865_RS12100	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HQ865_RS12120	COG4221	oxidoreductase activity
HQ865_RS12130	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HQ865_RS12140	COG1611	Belongs to the LOG family
HQ865_RS12180	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HQ865_RS12200	COG0456	acetyltransferase
HQ865_RS12205	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HQ865_RS12210	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
HQ865_RS12240	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HQ865_RS12260	COG0640	Transcriptional regulator
HQ865_RS12275	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
HQ865_RS12330	COG1278	Cold shock
HQ865_RS12345	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HQ865_RS12355	COG1480	7TM receptor with intracellular HD hydrolase
HQ865_RS12380	COG0284	orotidine-5'-phosphate decarboxylase activity
HQ865_RS12390	COG1183	phosphatidylcholine synthase activity
HQ865_RS12410	COG0616	signal peptide processing
HQ865_RS12420	COG1796	DNA polymerase
HQ865_RS12420	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HQ865_RS12425	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HQ865_RS12425	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HQ865_RS12430	COG0859	PFAM glycosyl transferase family 9
HQ865_RS12445	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HQ865_RS12445	COG0758	DNA mediated transformation
HQ865_RS12480	COG0357	Ribosomal RNA small subunit methyltransferase G
HQ865_RS12485	COG1595	DNA-templated transcription, initiation
HQ865_RS12490	COG1215	transferase activity, transferring glycosyl groups
HQ865_RS12495	COG0343	queuine tRNA-ribosyltransferase activity
HQ865_RS12515	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HQ865_RS12520	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HQ865_RS12535	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HQ865_RS12540	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HQ865_RS12545	COG1252	NADH dehydrogenase
HQ865_RS12565	COG0191	fructose-bisphosphate aldolase activity
HQ865_RS12570	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HQ865_RS12595	COG1104	cysteine desulfurase activity
HQ865_RS12600	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HQ865_RS12605	COG0671	phosphoesterase, PA-phosphatase related
HQ865_RS12620	COG1846	Transcriptional regulator
HQ865_RS12655	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HQ865_RS12665	COG1132	(ABC) transporter
HQ865_RS12680	COG2239	Acts as a magnesium transporter
HQ865_RS12685	COG0012	GTP binding
HQ865_RS12690	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HQ865_RS12700	COG2814	Major facilitator Superfamily
HQ865_RS12715	COG2188	Transcriptional regulator
HQ865_RS12720	COG3119	arylsulfatase activity
HQ865_RS12725	COG1629	transport
HQ865_RS12725	COG4206	TonB-dependent receptor
HQ865_RS12730	COG0702	epimerase
HQ865_RS12765	COG0702	epimerase
HQ865_RS12770	COG4771	TonB-dependent receptor
HQ865_RS12780	COG1609	Transcriptional regulator
HQ865_RS12800	COG3279	Response regulator of the LytR AlgR family
HQ865_RS12845	COG1858	cytochrome C peroxidase
HQ865_RS12860	COG2226	methyltransferase
HQ865_RS12870	COG0655	NAD(P)H dehydrogenase (quinone) activity
HQ865_RS12890	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HQ865_RS12895	COG2310	stress, protein
HQ865_RS12925	COG3853	Toxic anion resistance protein (TelA)
HQ865_RS12935	COG0861	Integral membrane protein TerC family
HQ865_RS12945	COG0671	phosphoesterase, PA-phosphatase related
HQ865_RS12955	COG1349	DNA-binding transcription factor activity
HQ865_RS12960	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HQ865_RS12965	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HQ865_RS12970	COG1442	glycosyl transferase family 8
HQ865_RS12970	COG1216	Glycosyl transferase, family 2
HQ865_RS12985	COG2271	Major facilitator Superfamily
HQ865_RS12990	COG0584	glycerophosphoryl diester phosphodiesterase
HQ865_RS13005	COG4206	TonB-dependent receptor
HQ865_RS13005	COG1629	transport
HQ865_RS13010	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HQ865_RS13015	COG1312	Catalyzes the dehydration of D-mannonate
HQ865_RS13060	COG0640	Transcriptional regulator
HQ865_RS13065	COG0824	Thioesterase
HQ865_RS13075	COG1121	(ABC) transporter
HQ865_RS13085	COG1181	Belongs to the D-alanine--D-alanine ligase family
HQ865_RS13110	COG1295	ribonuclease BN
HQ865_RS13125	COG0612	Peptidase, M16
HQ865_RS13130	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HQ865_RS13135	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HQ865_RS13140	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HQ865_RS13155	COG4771	TonB-dependent receptor
HQ865_RS13175	COG0612	Peptidase, M16
HQ865_RS13180	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HQ865_RS13185	COG0702	epimerase
HQ865_RS13190	COG4771	TonB-dependent receptor
HQ865_RS13205	COG0584	glycerophosphoryl diester phosphodiesterase
HQ865_RS13215	COG4771	TonB-dependent receptor
HQ865_RS13220	COG0702	epimerase
HQ865_RS13275	COG0702	epimerase
HQ865_RS13280	COG1629	transport
HQ865_RS13280	COG4206	TonB-dependent receptor
HQ865_RS13285	COG3292	Two component regulator propeller
HQ865_RS13285	COG2205	protein histidine kinase activity
HQ865_RS13285	COG0745	RESPONSE REGULATOR receiver
HQ865_RS13295	COG4941	Belongs to the sigma-70 factor family
HQ865_RS13305	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HQ865_RS13315	COG0025	NhaP-type Na H and K H
HQ865_RS13325	COG1629	transport
HQ865_RS13345	COG0745	RESPONSE REGULATOR receiver
HQ865_RS13355	COG3940	Belongs to the glycosyl hydrolase 43 family
HQ865_RS13360	COG2205	protein histidine kinase activity
HQ865_RS13360	COG3292	Two component regulator propeller
HQ865_RS13360	COG0745	RESPONSE REGULATOR receiver
HQ865_RS13385	COG3292	Two component regulator propeller
HQ865_RS13385	COG2205	protein histidine kinase activity
HQ865_RS13385	COG0745	RESPONSE REGULATOR receiver
HQ865_RS13395	COG4771	TonB-dependent receptor
HQ865_RS13415	COG3867	Arabinogalactan endo-beta-1,4-galactanase
HQ865_RS13430	COG0673	inositol 2-dehydrogenase activity
HQ865_RS13450	COG0745	RESPONSE REGULATOR receiver
HQ865_RS13450	COG3292	Two component regulator propeller
HQ865_RS13450	COG2205	protein histidine kinase activity
HQ865_RS13465	COG0702	epimerase
HQ865_RS13470	COG1629	transport
HQ865_RS13490	COG3507	Belongs to the glycosyl hydrolase 43 family
HQ865_RS13510	COG0745	RESPONSE REGULATOR receiver
HQ865_RS13510	COG2205	protein histidine kinase activity
HQ865_RS13510	COG3292	Two component regulator propeller
HQ865_RS13525	COG4771	TonB-dependent receptor
HQ865_RS13535	COG2382	esterase
HQ865_RS13545	COG3661	Belongs to the glycosyl hydrolase 67 family
HQ865_RS13610	COG3250	beta-galactosidase activity
HQ865_RS13640	COG0702	epimerase
HQ865_RS13645	COG4771	TonB-dependent receptor
HQ865_RS13665	COG3279	Response regulator of the LytR AlgR family
HQ865_RS13690	COG4221	oxidoreductase activity
HQ865_RS13700	COG0477	Major facilitator Superfamily
HQ865_RS13715	COG2755	lipolytic protein G-D-S-L family
HQ865_RS13725	COG4677	pectinesterase activity
HQ865_RS13735	COG0702	epimerase
HQ865_RS13740	COG1629	transport
HQ865_RS13745	COG0745	RESPONSE REGULATOR receiver
HQ865_RS13745	COG3292	Two component regulator propeller
HQ865_RS13745	COG2205	protein histidine kinase activity
HQ865_RS13775	COG3458	cephalosporin-C deacetylase activity
HQ865_RS13785	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HQ865_RS13785	COG2755	lipolytic protein G-D-S-L family
HQ865_RS13795	COG1242	4 iron, 4 sulfur cluster binding
HQ865_RS13820	COG0492	ferredoxin-NADP+ reductase activity
HQ865_RS13825	COG3852	Histidine kinase
HQ865_RS13910	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HQ865_RS13915	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HQ865_RS13935	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HQ865_RS13950	COG5002	protein histidine kinase activity
HQ865_RS13960	COG0113	porphobilinogen synthase activity
HQ865_RS13965	COG0181	hydroxymethylbilane synthase activity
HQ865_RS13980	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HQ865_RS13995	COG2267	carboxylic ester hydrolase activity
HQ865_RS14015	COG3275	phosphorelay sensor kinase activity
HQ865_RS14025	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HQ865_RS14055	COG0714	Associated with various cellular activities
HQ865_RS14115	COG2027	D-alanyl-D-alanine carboxypeptidase
HQ865_RS14120	COG0531	amino acid
HQ865_RS14125	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HQ865_RS14165	COG1137	ATPase activity
HQ865_RS14180	COG1166	arginine decarboxylase activity
HQ865_RS14210	COG2755	lipolytic protein G-D-S-L family
HQ865_RS14210	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HQ865_RS14225	COG0789	Transcriptional regulator
HQ865_RS14225	COG4978	Transcriptional regulator
HQ865_RS14230	COG0045	succinate-CoA ligase (ADP-forming) activity
HQ865_RS14245	COG0438	transferase activity, transferring glycosyl groups
HQ865_RS14245	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HQ865_RS14260	COG2353	YceI-like domain
HQ865_RS14265	COG0009	L-threonylcarbamoyladenylate synthase
HQ865_RS14270	COG2264	protein methyltransferase activity
HQ865_RS14280	COG0149	triose-phosphate isomerase activity
HQ865_RS14290	COG0254	rRNA binding
HQ865_RS14300	COG0708	Exodeoxyribonuclease III
HQ865_RS14325	COG1104	cysteine desulfurase activity
HQ865_RS14330	COG0822	iron-sulfur transferase activity
HQ865_RS14335	COG0316	Belongs to the HesB IscA family
HQ865_RS14345	COG1069	ribulokinase activity
HQ865_RS14355	COG2160	L-arabinose isomerase activity
HQ865_RS14360	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HQ865_RS14375	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HQ865_RS14380	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HQ865_RS14385	COG0745	RESPONSE REGULATOR receiver
HQ865_RS14395	COG0564	pseudouridine synthase activity
HQ865_RS14445	COG0456	acetyltransferase
HQ865_RS14465	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HQ865_RS14500	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HQ865_RS14510	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HQ865_RS14525	COG0363	glucosamine-6-phosphate deaminase activity
HQ865_RS14530	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HQ865_RS14535	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HQ865_RS14545	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HQ865_RS14550	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HQ865_RS14555	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HQ865_RS14575	COG3279	Response regulator of the LytR AlgR family
HQ865_RS14580	COG3275	phosphorelay sensor kinase activity
HQ865_RS14605	COG0196	riboflavin kinase activity
HQ865_RS14610	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HQ865_RS14635	COG1899	peptidyl-lysine modification to peptidyl-hypusine
HQ865_RS14665	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HQ865_RS14710	COG0405	Gamma-glutamyltransferase
HQ865_RS14755	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HQ865_RS14755	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HQ865_RS14790	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HQ865_RS14795	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HQ865_RS14800	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HQ865_RS14805	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HQ865_RS14810	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HQ865_RS14815	COG0356	it plays a direct role in the translocation of protons across the membrane
HQ865_RS14835	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HQ865_RS14840	COG0322	excinuclease ABC activity
HQ865_RS14910	COG1523	belongs to the glycosyl hydrolase 13 family
HQ865_RS14915	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HQ865_RS14935	COG1904	glucuronate isomerase
HQ865_RS14970	COG1363	Peptidase, m42
HQ865_RS15010	COG0295	cytidine deaminase activity
HQ865_RS15055	COG3537	Alpha-1,2-mannosidase
HQ865_RS15085	COG5002	protein histidine kinase activity
HQ865_RS15095	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HQ865_RS15105	COG0583	DNA-binding transcription factor activity
HQ865_RS15115	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HQ865_RS15145	COG0784	Response regulator, receiver
HQ865_RS15145	COG2205	protein histidine kinase activity
HQ865_RS15150	COG0525	valine-tRNA ligase activity
HQ865_RS15190	COG4771	TonB-dependent receptor
HQ865_RS15220	COG1629	transport
HQ865_RS15230	COG1595	DNA-templated transcription, initiation
HQ865_RS15235	COG1459	type II secretion system
HQ865_RS15280	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HQ865_RS15355	COG3119	arylsulfatase activity
HQ865_RS15370	COG3345	alpha-galactosidase
HQ865_RS15375	COG3250	beta-galactosidase activity
HQ865_RS15420	COG4771	TonB-dependent receptor
HQ865_RS15435	COG0702	epimerase
HQ865_RS15440	COG1629	transport
HQ865_RS15450	COG0673	inositol 2-dehydrogenase activity
HQ865_RS15465	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HQ865_RS15475	COG0363	glucosamine-6-phosphate deaminase activity
HQ865_RS15480	COG1472	Belongs to the glycosyl hydrolase 3 family
HQ865_RS15485	COG1609	Transcriptional regulator
HQ865_RS15500	COG0243	molybdopterin cofactor binding
HQ865_RS15505	COG2223	nitrite transmembrane transporter activity
HQ865_RS15520	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HQ865_RS15520	COG2146	nitrite reductase [NAD(P)H] activity
HQ865_RS15525	COG2146	nitrite reductase [NAD(P)H] activity
HQ865_RS15525	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HQ865_RS15530	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HQ865_RS15530	COG1648	precorrin-2 dehydrogenase activity
HQ865_RS15545	COG3220	belongs to the UPF0276 family
HQ865_RS15580	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HQ865_RS15585	COG3279	Response regulator of the LytR AlgR family
HQ865_RS15590	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HQ865_RS15605	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HQ865_RS15610	COG1132	(ABC) transporter
HQ865_RS15615	COG0101	tRNA pseudouridine synthase activity
HQ865_RS15625	COG1090	epimerase
HQ865_RS15630	COG0415	Belongs to the DNA photolyase family
HQ865_RS15660	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HQ865_RS15665	COG1522	sequence-specific DNA binding
HQ865_RS15675	COG1914	H( )-stimulated, divalent metal cation uptake system
HQ865_RS15680	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HQ865_RS15715	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HQ865_RS15720	COG1192	Involved in chromosome partitioning
HQ865_RS15725	COG1475	DNA binding
HQ865_RS15735	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HQ865_RS15760	COG0745	RESPONSE REGULATOR receiver
HQ865_RS15825	COG2322	membrane
HQ865_RS15830	COG1999	signal sequence binding
HQ865_RS15845	COG1845	cytochrome c oxidase, subunit III
HQ865_RS15850	COG0109	protoheme IX farnesyltransferase activity
HQ865_RS15860	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HQ865_RS15890	COG0437	4 iron, 4 sulfur cluster binding
HQ865_RS15905	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HQ865_RS15910	COG3938	Belongs to the proline racemase family
HQ865_RS15920	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HQ865_RS15930	COG1674	ftsk spoiiie
HQ865_RS15940	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HQ865_RS15960	COG2197	response regulator
HQ865_RS15965	COG2205	protein histidine kinase activity
HQ865_RS15965	COG3292	Two component regulator propeller
HQ865_RS15965	COG0745	RESPONSE REGULATOR receiver
HQ865_RS15965	COG0745	RESPONSE REGULATOR receiver
HQ865_RS15965	COG2205	protein histidine kinase activity
HQ865_RS15965	COG3292	Two component regulator propeller
HQ865_RS15975	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HQ865_RS16005	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HQ865_RS16010	COG2731	YhcH YjgK YiaL family protein
HQ865_RS16020	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HQ865_RS16025	COG2363	Small membrane protein
HQ865_RS16055	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HQ865_RS16060	COG0640	Transcriptional regulator
HQ865_RS16070	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HQ865_RS16075	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HQ865_RS16090	COG1629	transport
HQ865_RS16095	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HQ865_RS16110	COG2205	protein histidine kinase activity
HQ865_RS16110	COG0784	Response regulator, receiver
HQ865_RS16115	COG1136	(ABC) transporter
HQ865_RS16115	COG0577	efflux transmembrane transporter activity
HQ865_RS16120	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HQ865_RS16155	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HQ865_RS16160	COG3408	Glycogen debranching enzyme
HQ865_RS16160	COG3119	arylsulfatase activity
HQ865_RS16165	COG1846	Transcriptional regulator
HQ865_RS16170	COG1595	DNA-templated transcription, initiation
HQ865_RS16190	COG2986	histidine ammonia-lyase
HQ865_RS16195	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HQ865_RS16200	COG1228	amidohydrolase
HQ865_RS16225	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HQ865_RS16240	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HQ865_RS16245	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HQ865_RS16255	COG0552	protein localization to endoplasmic reticulum
HQ865_RS16260	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HQ865_RS16265	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
HQ865_RS16280	COG0436	Aminotransferase
HQ865_RS16285	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HQ865_RS16290	COG2366	antibiotic biosynthetic process
HQ865_RS16295	COG2814	Major facilitator Superfamily
HQ865_RS16300	COG0457	Tetratricopeptide repeat
HQ865_RS16310	COG1082	Xylose isomerase domain protein TIM barrel
HQ865_RS16315	COG0673	inositol 2-dehydrogenase activity
HQ865_RS16345	COG3279	Response regulator of the LytR AlgR family
HQ865_RS16350	COG3275	phosphorelay sensor kinase activity
HQ865_RS16385	COG3186	Phenylalanine-4-hydroxylase
HQ865_RS16400	COG4221	oxidoreductase activity
HQ865_RS16410	COG0436	Aminotransferase
HQ865_RS16420	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HQ865_RS16455	COG3693	PFAM glycoside hydrolase, family 10
HQ865_RS16455	COG2382	esterase
HQ865_RS16455	COG3507	Belongs to the glycosyl hydrolase 43 family
HQ865_RS16460	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HQ865_RS16470	COG0738	Major facilitator superfamily
HQ865_RS16475	COG3254	rhamnose metabolic process
HQ865_RS16485	COG1607	acyl-coa hydrolase
HQ865_RS16490	COG0443	Heat shock 70 kDa protein
HQ865_RS16500	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HQ865_RS16510	COG0203	ribosomal protein L17
HQ865_RS16515	COG0202	RNA polymerase activity
HQ865_RS16520	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HQ865_RS16525	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HQ865_RS16530	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HQ865_RS16535	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HQ865_RS16540	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HQ865_RS16555	COG0200	Binds to the 23S rRNA
HQ865_RS16560	COG1841	ribosomal large subunit assembly
HQ865_RS16565	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HQ865_RS16570	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HQ865_RS16575	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HQ865_RS16580	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HQ865_RS16585	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HQ865_RS16590	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HQ865_RS16595	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HQ865_RS16600	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HQ865_RS16605	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HQ865_RS16610	COG0255	Belongs to the universal ribosomal protein uL29 family
HQ865_RS16615	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HQ865_RS16620	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HQ865_RS16625	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HQ865_RS16630	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HQ865_RS16635	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HQ865_RS16640	COG0089	rRNA binding
HQ865_RS16645	COG0088	Forms part of the polypeptide exit tunnel
HQ865_RS16650	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HQ865_RS16665	COG0705	Rhomboid family
HQ865_RS16715	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HQ865_RS16740	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HQ865_RS16755	COG0477	Major facilitator Superfamily
HQ865_RS16770	COG1028	Short-chain dehydrogenase reductase Sdr
HQ865_RS16775	COG2133	pyrroloquinoline quinone binding
HQ865_RS16785	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HQ865_RS16805	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HQ865_RS16810	COG0540	Belongs to the ATCase OTCase family
HQ865_RS16825	COG2177	Part of the ABC transporter FtsEX involved in
HQ865_RS16835	COG1968	undecaprenyl-diphosphatase activity
HQ865_RS16890	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HQ865_RS16900	COG1607	acyl-coa hydrolase
HQ865_RS16910	COG1454	alcohol dehydrogenase
HQ865_RS16915	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HQ865_RS16920	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HQ865_RS16925	COG3395	kinase activity
HQ865_RS16930	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HQ865_RS16945	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HQ865_RS16955	COG4585	Histidine kinase
HQ865_RS16960	COG0252	asparaginase activity
HQ865_RS16965	COG0084	hydrolase, TatD family'
HQ865_RS16985	COG0545	Peptidyl-prolyl cis-trans isomerase
HQ865_RS16995	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HQ865_RS17000	COG0105	UTP biosynthetic process
HQ865_RS17015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HQ865_RS17025	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HQ865_RS17035	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HQ865_RS17060	COG1595	DNA-templated transcription, initiation
HQ865_RS17075	COG0670	Belongs to the BI1 family
HQ865_RS17085	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HQ865_RS17090	COG0793	Belongs to the peptidase S41A family
HQ865_RS17095	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HQ865_RS17100	COG0604	alcohol dehydrogenase
HQ865_RS17130	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
HQ865_RS17135	COG0745	RESPONSE REGULATOR receiver
HQ865_RS17140	COG5002	protein histidine kinase activity
HQ865_RS17150	COG0438	transferase activity, transferring glycosyl groups
HQ865_RS17165	COG1132	(ABC) transporter
HQ865_RS17170	COG1216	Glycosyl transferase, family 2
HQ865_RS17175	COG1216	Glycosyl transferase, family 2
HQ865_RS17205	COG1472	Belongs to the glycosyl hydrolase 3 family
HQ865_RS17215	COG0210	DNA helicase
HQ865_RS17245	COG3275	phosphorelay sensor kinase activity
HQ865_RS17305	COG0187	DNA topoisomerase II activity
HQ865_RS17315	COG0590	tRNA wobble adenosine to inosine editing
HQ865_RS17325	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HQ865_RS17360	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HQ865_RS17365	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HQ865_RS17370	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HQ865_RS17400	COG0673	inositol 2-dehydrogenase activity
HQ865_RS17430	COG1083	cytidylyl-transferase
HQ865_RS17440	COG0483	inositol monophosphate 1-phosphatase activity
HQ865_RS17445	COG1028	Short-chain dehydrogenase reductase Sdr
HQ865_RS17450	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HQ865_RS17455	COG0673	inositol 2-dehydrogenase activity
HQ865_RS17460	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HQ865_RS17480	COG0438	transferase activity, transferring glycosyl groups
HQ865_RS17485	COG2382	esterase
HQ865_RS17485	COG3507	Belongs to the glycosyl hydrolase 43 family
HQ865_RS17485	COG3693	PFAM glycoside hydrolase, family 10
HQ865_RS17490	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HQ865_RS17505	COG1215	transferase activity, transferring glycosyl groups
HQ865_RS17520	COG2089	acid synthase
HQ865_RS17525	COG0028	Belongs to the TPP enzyme family
HQ865_RS17530	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HQ865_RS17545	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HQ865_RS17550	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HQ865_RS17555	COG0489	protein tyrosine kinase activity
HQ865_RS17575	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HQ865_RS17580	COG0085	RNA polymerase activity
HQ865_RS17585	COG0222	ribosome binding
HQ865_RS17590	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HQ865_RS17595	COG0081	regulation of translation
HQ865_RS17600	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HQ865_RS17650	COG4974	Belongs to the 'phage' integrase family
HQ865_RS17655	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HQ865_RS17675	COG1960	acyl-CoA dehydrogenase activity
HQ865_RS17680	COG0300	oxidoreductase activity
HQ865_RS17690	COG0745	RESPONSE REGULATOR receiver
HQ865_RS17705	COG0495	leucyl-tRNA aminoacylation
HQ865_RS17710	COG1435	thymidine kinase activity
HQ865_RS17730	COG1917	Cupin 2, conserved barrel domain protein
HQ865_RS17740	COG2271	Major facilitator Superfamily
HQ865_RS17750	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HQ865_RS17750	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HQ865_RS17780	COG1064	alcohol dehydrogenase
HQ865_RS17795	COG0303	'Molybdopterin
HQ865_RS17805	COG0746	molybdenum cofactor guanylyltransferase activity
HQ865_RS17815	COG0314	molybdopterin synthase activity
HQ865_RS17825	COG1301	dicarboxylic acid transport
HQ865_RS17830	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HQ865_RS17845	COG0564	pseudouridine synthase activity
HQ865_RS17850	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HQ865_RS17855	COG0505	Belongs to the CarA family
HQ865_RS17860	COG1216	Glycosyl transferase, family 2
HQ865_RS17865	COG0438	transferase activity, transferring glycosyl groups
HQ865_RS17870	COG1045	serine acetyltransferase
HQ865_RS17885	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HQ865_RS17900	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HQ865_RS17905	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HQ865_RS17925	COG1393	Belongs to the ArsC family
HQ865_RS17935	COG0193	aminoacyl-tRNA hydrolase activity
HQ865_RS17950	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HQ865_RS17955	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HQ865_RS17995	COG3118	belongs to the thioredoxin family
HQ865_RS18000	COG1040	competence protein
HQ865_RS18025	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HQ865_RS18030	COG0556	nucleotide-excision repair
HQ865_RS18055	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HQ865_RS18080	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HQ865_RS18085	COG1595	DNA-templated transcription, initiation
HQ865_RS18115	COG0653	protein targeting
HQ865_RS18135	COG0151	Belongs to the GarS family
HQ865_RS18145	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HQ865_RS18155	COG1392	Phosphate transport regulator
HQ865_RS18170	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HQ865_RS18175	COG1663	tetraacyldisaccharide 4'-kinase activity
HQ865_RS18220	COG5002	protein histidine kinase activity
HQ865_RS18225	COG0745	RESPONSE REGULATOR receiver
HQ865_RS18250	COG1388	LysM domain
HQ865_RS18250	COG3584	3D domain protein
HQ865_RS18255	COG0154	amidase activity
HQ865_RS18260	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HQ865_RS18265	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HQ865_RS18285	COG0756	dUTP diphosphatase activity
HQ865_RS18295	COG1254	Belongs to the acylphosphatase family
HQ865_RS18300	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HQ865_RS18305	COG3483	tryptophan 2,3-dioxygenase activity
HQ865_RS18315	COG0363	glucosamine-6-phosphate deaminase activity
HQ865_RS18330	COG1028	Short-chain dehydrogenase reductase Sdr
HQ865_RS18345	COG0321	lipoyl(octanoyl) transferase activity
HQ865_RS18360	COG0612	Peptidase, M16
HQ865_RS18370	COG2205	protein histidine kinase activity
HQ865_RS18380	COG0423	glycine-tRNA ligase activity
HQ865_RS18410	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HQ865_RS18415	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HQ865_RS18420	COG3275	phosphorelay sensor kinase activity
HQ865_RS18425	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HQ865_RS18435	COG3279	Response regulator of the LytR AlgR family
HQ865_RS18445	COG0545	Peptidyl-prolyl cis-trans isomerase
HQ865_RS18450	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HQ865_RS18465	COG2972	Histidine kinase
HQ865_RS18470	COG3279	Response regulator of the LytR AlgR family
HQ865_RS18480	COG0038	chloride channel
HQ865_RS18485	COG0589	response to stress
HQ865_RS18500	COG1999	signal sequence binding
HQ865_RS18505	COG1011	Hydrolase
HQ865_RS18510	COG1598	PFAM Uncharacterised protein family UPF0150
HQ865_RS18555	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HQ865_RS18575	COG0592	DNA-directed DNA polymerase activity
HQ865_RS18605	COG0612	Peptidase, M16
HQ865_RS18635	COG0586	Pfam SNARE associated Golgi protein
HQ865_RS18665	COG0268	Binds directly to 16S ribosomal RNA
HQ865_RS18670	COG2003	Belongs to the UPF0758 family
HQ865_RS18705	COG1418	mRNA catabolic process
HQ865_RS18710	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HQ865_RS18715	COG1595	DNA-templated transcription, initiation
HQ865_RS18745	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HQ865_RS18755	COG2183	response to ionizing radiation
HQ865_RS18760	COG2819	hydrolase of the alpha beta superfamily
HQ865_RS18765	COG0714	Associated with various cellular activities
HQ865_RS18770	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HQ865_RS18780	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HQ865_RS18800	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HQ865_RS18810	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HQ865_RS18815	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HQ865_RS18820	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HQ865_RS18855	COG1131	(ABC) transporter
HQ865_RS18860	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HQ865_RS18865	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HQ865_RS18865	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HQ865_RS18870	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HQ865_RS18875	COG1078	dGTPase activity
HQ865_RS18900	COG0686	Belongs to the AlaDH PNT family
HQ865_RS18925	COG1522	sequence-specific DNA binding
HQ865_RS18930	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HQ865_RS18950	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HQ865_RS18955	COG1295	ribonuclease BN
HQ865_RS18980	COG0793	Belongs to the peptidase S41A family
HQ865_RS19010	COG1561	YicC-like family, N-terminal region
HQ865_RS19015	COG0194	GDP metabolic process
HQ865_RS19020	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HQ865_RS19065	COG5002	protein histidine kinase activity
HQ865_RS19070	COG0745	RESPONSE REGULATOR receiver
HQ865_RS19095	COG0509	glycine decarboxylation via glycine cleavage system
HQ865_RS19105	COG4941	Belongs to the sigma-70 factor family
HQ865_RS19120	COG0825	malonyl-CoA metabolic process
HQ865_RS19130	COG0508	dehydrogenase complex catalyzes the overall conversion of
HQ865_RS19135	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HQ865_RS19195	COG4206	TonB-dependent receptor
HQ865_RS19195	COG1629	transport
HQ865_RS19220	COG4206	TonB-dependent receptor
HQ865_RS19230	COG0583	DNA-binding transcription factor activity
HQ865_RS19240	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HQ865_RS19250	COG0297	glycogen (starch) synthase activity
HQ865_RS19255	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HQ865_RS19260	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HQ865_RS19280	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HQ865_RS19320	COG1012	belongs to the aldehyde dehydrogenase family
HQ865_RS19335	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HQ865_RS19345	COG4591	ABC-type transport system involved in lipoprotein release permease component
HQ865_RS19355	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HQ865_RS19375	COG0741	lytic transglycosylase activity
HQ865_RS19375	COG0739	heme binding
HQ865_RS19375	COG1196	nuclear chromosome segregation
HQ865_RS19380	COG1196	nuclear chromosome segregation
HQ865_RS19380	COG0741	lytic transglycosylase activity
HQ865_RS19380	COG0739	heme binding
HQ865_RS19390	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HQ865_RS19405	COG2267	carboxylic ester hydrolase activity
HQ865_RS19420	COG0571	ribonuclease III activity
HQ865_RS19425	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HQ865_RS19430	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HQ865_RS19455	COG0702	epimerase
HQ865_RS19460	COG4771	TonB-dependent receptor
HQ865_RS19465	COG3250	beta-galactosidase activity
HQ865_RS19470	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HQ865_RS19475	COG3345	alpha-galactosidase
HQ865_RS19505	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HQ865_RS19505	COG0116	Belongs to the methyltransferase superfamily
HQ865_RS19520	COG1418	mRNA catabolic process
HQ865_RS19565	COG5002	protein histidine kinase activity
HQ865_RS19575	COG0306	phosphate transporter
HQ865_RS19595	COG3290	protein histidine kinase activity
HQ865_RS19605	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HQ865_RS19605	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HQ865_RS19610	COG2197	response regulator
HQ865_RS19660	COG0667	Aldo Keto reductase
HQ865_RS19685	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
HQ865_RS19695	COG1335	isochorismatase
HQ865_RS19715	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HQ865_RS19750	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HQ865_RS19765	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HQ865_RS19790	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HQ865_RS19795	COG4948	Mandelate Racemase Muconate Lactonizing
HQ865_RS19800	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HQ865_RS19810	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HQ865_RS19825	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HQ865_RS19835	COG2211	Major facilitator Superfamily
HQ865_RS19840	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HQ865_RS19860	COG0792	nuclease activity
HQ865_RS19865	COG0358	DNA primase activity
HQ865_RS19880	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HQ865_RS19890	COG4680	protein conserved in bacteria
HQ865_RS19915	COG4771	TonB-dependent receptor
HQ865_RS19935	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HQ865_RS19935	COG4447	cellulose binding
HQ865_RS19950	COG3041	Addiction module toxin RelE StbE family
HQ865_RS19965	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
HQ865_RS19985	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HQ865_RS19995	COG1487	ribonuclease activity
HQ865_RS20000	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HQ865_RS20020	COG4115	mRNA cleavage
HQ865_RS20025	COG2161	toxin-antitoxin pair type II binding
HQ865_RS20040	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HQ865_RS20055	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HQ865_RS20065	COG2721	sulfolactate sulfo-lyase activity
HQ865_RS20075	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HQ865_RS20105	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HQ865_RS20110	COG2234	aminopeptidase activity
HQ865_RS20125	COG0577	efflux transmembrane transporter activity
HQ865_RS20125	COG1136	(ABC) transporter
HQ865_RS20130	COG0242	peptide deformylase activity
HQ865_RS20135	COG1690	Belongs to the RtcB family
HQ865_RS20140	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HQ865_RS20150	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HQ865_RS20175	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HQ865_RS20185	COG1309	transcriptional regulator
HQ865_RS20195	COG0330	HflC and HflK could
HQ865_RS20210	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HQ865_RS20215	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HQ865_RS20220	COG0577	efflux transmembrane transporter activity
HQ865_RS20250	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HQ865_RS20260	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HQ865_RS20265	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HQ865_RS20310	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HQ865_RS20345	COG2204	response regulator
HQ865_RS20355	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HQ865_RS20360	COG1288	antiporter activity
HQ865_RS20390	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HQ865_RS20395	COG0386	Belongs to the glutathione peroxidase family
HQ865_RS20405	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HQ865_RS20415	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HQ865_RS20415	COG2755	lipolytic protein G-D-S-L family
HQ865_RS20420	COG3530	Putative quorum-sensing-regulated virulence factor
HQ865_RS20455	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HQ865_RS20510	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HQ865_RS20555	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HQ865_RS20565	COG3119	arylsulfatase activity
HQ865_RS20620	COG2070	2-Nitropropane dioxygenase
HQ865_RS20640	COG2885	chlorophyll binding
HQ865_RS20675	COG2321	neutral zinc metallopeptidase
HQ865_RS20680	COG1028	Short-chain dehydrogenase reductase Sdr
HQ865_RS20685	COG5002	protein histidine kinase activity
HQ865_RS20700	COG0477	Major facilitator Superfamily
HQ865_RS20705	COG3119	arylsulfatase activity
HQ865_RS20715	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HQ865_RS20720	COG0438	transferase activity, transferring glycosyl groups
HQ865_RS20735	COG3279	Response regulator of the LytR AlgR family
HQ865_RS20740	COG2972	Histidine kinase
HQ865_RS20750	COG0494	nUDIX hydrolase
HQ865_RS20770	COG1704	LemA family
HQ865_RS20775	COG3537	Alpha-1,2-mannosidase
HQ865_RS20810	COG2308	Evidence 4 Homologs of previously reported genes of
HQ865_RS20820	COG1305	Transglutaminase-like
HQ865_RS20830	COG1858	cytochrome C peroxidase
HQ865_RS20885	COG2169	Transcriptional regulator
HQ865_RS20900	COG1793	dna ligase
HQ865_RS20920	COG3541	Predicted nucleotidyltransferase
HQ865_RS20960	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HQ865_RS20960	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HQ865_RS20970	COG2201	protein-glutamate methylesterase activity
HQ865_RS20995	COG1752	Esterase of the alpha-beta hydrolase superfamily
HQ865_RS21000	COG0336	Belongs to the RNA methyltransferase TrmD family
HQ865_RS21005	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HQ865_RS21020	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HQ865_RS21030	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HQ865_RS21040	COG1028	Short-chain dehydrogenase reductase Sdr
HQ865_RS21045	COG2986	histidine ammonia-lyase
HQ865_RS21050	COG1764	response to oxidative stress
HQ865_RS21065	COG0017	Asparaginyl-tRNA synthetase
HQ865_RS21080	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HQ865_RS21085	COG0217	transcriptional regulatory protein
HQ865_RS21110	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HQ865_RS21110	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HQ865_RS21115	COG1619	proteins homologs of microcin C7 resistance protein MccF
HQ865_RS21120	COG2259	Doxx family
HQ865_RS21140	COG1629	transport
HQ865_RS21140	COG4206	TonB-dependent receptor
HQ865_RS21145	COG1695	Transcriptional regulator
HQ865_RS21150	COG1983	PspC domain protein
HQ865_RS21165	COG0514	ATP-dependent DNA helicase (RecQ)
HQ865_RS21170	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HQ865_RS21185	COG4589	Belongs to the CDS family
HQ865_RS21200	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HQ865_RS21205	COG2967	ApaG domain
HQ865_RS21225	COG1090	epimerase
HQ865_RS21255	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HQ865_RS21260	COG2706	6-phosphogluconolactonase activity
HQ865_RS21265	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HQ865_RS21310	COG3655	Transcriptional regulator
HQ865_RS21390	COG0335	large ribosomal subunit rRNA binding
HQ865_RS21400	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HQ865_RS21410	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
HQ865_RS21415	COG4251	negative regulation of phosphorylation
HQ865_RS21420	COG4251	negative regulation of phosphorylation
HQ865_RS21425	COG5002	protein histidine kinase activity
HQ865_RS21435	COG1960	acyl-CoA dehydrogenase activity
HQ865_RS21470	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HQ865_RS21475	COG1160	GTP binding
HQ865_RS21480	COG2267	carboxylic ester hydrolase activity
HQ865_RS21490	COG0640	Transcriptional regulator
HQ865_RS21495	COG0300	oxidoreductase activity
HQ865_RS21535	COG0673	inositol 2-dehydrogenase activity
HQ865_RS21540	COG1477	protein flavinylation
HQ865_RS21550	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HQ865_RS21575	COG3279	Response regulator of the LytR AlgR family
HQ865_RS21580	COG3275	phosphorelay sensor kinase activity
HQ865_RS21590	COG2353	YceI-like domain
HQ865_RS21620	COG0134	indole-3-glycerol-phosphate synthase activity
HQ865_RS21625	COG0512	Glutamine amidotransferase of anthranilate synthase
HQ865_RS21655	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HQ865_RS21660	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HQ865_RS21675	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HQ865_RS21685	COG0445	tRNA wobble uridine modification
HQ865_RS21695	COG0488	(ABC) transporter
HQ865_RS21705	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HQ865_RS21710	COG1127	ABC transporter
HQ865_RS21720	COG1309	transcriptional regulator
HQ865_RS21730	COG0297	glycogen (starch) synthase activity
HQ865_RS21735	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HQ865_RS21750	COG0154	amidase activity
HQ865_RS21755	COG2318	DinB family
HQ865_RS21795	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HQ865_RS21800	COG1028	Short-chain dehydrogenase reductase Sdr
HQ865_RS21810	COG0179	Fumarylacetoacetate (FAA) hydrolase
HQ865_RS21820	COG1028	Short-chain dehydrogenase reductase Sdr
HQ865_RS21830	COG1012	belongs to the aldehyde dehydrogenase family
HQ865_RS21865	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HQ865_RS21870	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HQ865_RS21875	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HQ865_RS21885	COG1139	Iron-sulfur cluster binding protein
HQ865_RS21890	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HQ865_RS21920	COG3250	beta-galactosidase activity
HQ865_RS21935	COG4771	TonB-dependent receptor
HQ865_RS21940	COG1312	Catalyzes the dehydration of D-mannonate
HQ865_RS21955	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HQ865_RS21995	COG0037	tRNA processing
HQ865_RS22010	COG5002	protein histidine kinase activity
HQ865_RS22010	COG3850	Histidine kinase
HQ865_RS22015	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HQ865_RS22030	COG2045	Belongs to the ComB family
HQ865_RS22060	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HQ865_RS22070	COG0564	pseudouridine synthase activity
HQ865_RS22080	COG1294	oxidase, subunit
HQ865_RS22085	COG1271	oxidase subunit
HQ865_RS22090	COG1187	pseudouridine synthase activity
HQ865_RS22100	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HQ865_RS22110	COG1381	Involved in DNA repair and RecF pathway recombination
HQ865_RS22120	COG3279	Response regulator of the LytR AlgR family
HQ865_RS22165	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HQ865_RS22175	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HQ865_RS22190	COG1028	Short-chain dehydrogenase reductase Sdr
HQ865_RS22195	COG1215	transferase activity, transferring glycosyl groups
HQ865_RS22210	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HQ865_RS22215	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HQ865_RS22220	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HQ865_RS22230	COG1024	Enoyl-CoA hydratase
HQ865_RS22235	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HQ865_RS22235	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HQ865_RS22240	COG0537	adenosine 5'-monophosphoramidase activity
HQ865_RS22245	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HQ865_RS22250	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HQ865_RS22270	COG0612	Peptidase, M16
HQ865_RS22275	COG0724	RNA recognition motif
HQ865_RS22300	COG0124	histidyl-tRNA synthetase
HQ865_RS22310	COG1649	PFAM Uncharacterised BCR, COG1649
HQ865_RS22315	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HQ865_RS22320	COG1595	DNA-templated transcription, initiation
HQ865_RS22350	COG0024	Methionine aminopeptidase
HQ865_RS22385	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HQ865_RS22410	COG0531	amino acid
HQ865_RS22415	COG2226	methyltransferase
HQ865_RS22425	COG1741	Belongs to the pirin family
HQ865_RS22450	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HQ865_RS22475	COG0508	dehydrogenase complex catalyzes the overall conversion of
HQ865_RS22480	COG0708	Exodeoxyribonuclease III
HQ865_RS22495	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HQ865_RS22500	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HQ865_RS22505	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HQ865_RS22535	COG2814	Major facilitator Superfamily
HQ865_RS22565	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HQ865_RS22565	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HQ865_RS22580	COG0519	Catalyzes the synthesis of GMP from XMP
HQ865_RS22605	COG2304	oxidoreductase activity
HQ865_RS22615	COG4771	TonB-dependent receptor
HQ865_RS22720	COG3209	COG3209 Rhs family protein
HQ865_RS22830	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HQ865_RS22835	COG0517	IMP dehydrogenase activity
HQ865_RS22835	COG1125	glycine betaine transport
HQ865_RS22845	COG1174	glycine betaine transport
HQ865_RS22850	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HQ865_RS22855	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
HQ865_RS22875	COG1053	succinate dehydrogenase
HQ865_RS22885	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HQ865_RS22900	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HQ865_RS22905	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
HQ865_RS22910	COG0736	holo-[acyl-carrier-protein] synthase activity
HQ865_RS22945	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HQ865_RS22955	COG3590	peptidase
HQ865_RS22970	COG2195	Cleaves the N-terminal amino acid of tripeptides
HQ865_RS22980	COG2315	Protein conserved in bacteria
HQ865_RS22995	COG0215	cysteine-tRNA ligase activity
HQ865_RS23005	COG2442	InterPro IPR007367
HQ865_RS23015	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HQ865_RS23020	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HQ865_RS23030	COG3279	Response regulator of the LytR AlgR family
HQ865_RS23055	COG0494	nUDIX hydrolase
HQ865_RS23065	COG0528	UMP kinase activity
HQ865_RS23070	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HQ865_RS23075	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HQ865_RS23080	COG0052	Belongs to the universal ribosomal protein uS2 family
HQ865_RS23085	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HQ865_RS23090	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HQ865_RS23095	COG0606	chelatase, subunit chli
HQ865_RS23115	COG2610	gluconate transmembrane transporter activity
HQ865_RS23120	COG1070	Carbohydrate kinase
HQ865_RS23150	COG5180	pathogenesis
HQ865_RS23150	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HQ865_RS23155	COG0195	Participates in both transcription termination and antitermination
HQ865_RS23160	COG0779	Required for maturation of 30S ribosomal subunits
HQ865_RS23170	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HQ865_RS23175	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HQ865_RS23190	COG0673	inositol 2-dehydrogenase activity
HQ865_RS23200	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
HQ865_RS23220	COG0302	gtp cyclohydrolase
HQ865_RS23225	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HQ865_RS23230	COG5000	phosphorelay sensor kinase activity
HQ865_RS23240	COG1733	regulation of RNA biosynthetic process
HQ865_RS23245	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HQ865_RS23270	COG4585	Histidine kinase
HQ865_RS23290	COG1556	Lactate utilization protein
HQ865_RS23320	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HQ865_RS23365	COG0228	four-way junction DNA binding
HQ865_RS23370	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HQ865_RS23395	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HQ865_RS23405	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HQ865_RS23425	COG2814	Major facilitator Superfamily
HQ865_RS23440	COG0492	ferredoxin-NADP+ reductase activity
HQ865_RS23450	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HQ865_RS23455	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HQ865_RS23460	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HQ865_RS23465	COG4771	TonB-dependent receptor
HQ865_RS23485	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HQ865_RS23490	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HQ865_RS23495	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HQ865_RS23500	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HQ865_RS23515	COG4232	protein-disulfide reductase activity
HQ865_RS23520	COG1104	cysteine desulfurase activity
HQ865_RS23525	COG0730	response to heat
HQ865_RS23530	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HQ865_RS23530	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HQ865_RS23535	COG1522	sequence-specific DNA binding
HQ865_RS23560	COG2205	protein histidine kinase activity
HQ865_RS23580	COG2814	Major facilitator Superfamily
HQ865_RS23595	COG0667	Aldo Keto reductase
HQ865_RS23600	COG4771	TonB-dependent receptor
HQ865_RS23625	COG4948	Mandelate Racemase Muconate Lactonizing
HQ865_RS23630	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HQ865_RS23640	COG3119	arylsulfatase activity
HQ865_RS23650	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HQ865_RS23660	COG0667	Aldo Keto reductase
HQ865_RS23670	COG1028	Short-chain dehydrogenase reductase Sdr
HQ865_RS23675	COG1028	Short-chain dehydrogenase reductase Sdr
HQ865_RS23685	COG1012	belongs to the aldehyde dehydrogenase family
HQ865_RS23690	COG1454	alcohol dehydrogenase
HQ865_RS23700	COG0251	oxidation-reduction process
HQ865_RS23710	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HQ865_RS23730	COG0179	Fumarylacetoacetate (FAA) hydrolase
HQ865_RS23740	COG0247	lactate metabolic process
HQ865_RS23740	COG0277	FAD linked oxidase domain protein
HQ865_RS23750	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HQ865_RS23780	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HQ865_RS23790	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HQ865_RS23795	COG1028	Short-chain dehydrogenase reductase Sdr
HQ865_RS23810	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HQ865_RS23825	COG1131	(ABC) transporter
HQ865_RS23835	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HQ865_RS23840	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HQ865_RS23845	COG0489	protein tyrosine kinase activity
HQ865_RS23850	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HQ865_RS23860	COG1477	protein flavinylation
HQ865_RS23875	COG2234	aminopeptidase activity
HQ865_RS23890	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HQ865_RS23920	COG2204	response regulator
HQ865_RS23940	COG0805	protein transport
HQ865_RS23945	COG0439	Biotin carboxylase
HQ865_RS23950	COG0511	ligase activity, forming carbon-carbon bonds
HQ865_RS23955	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HQ865_RS23960	COG0416	fatty acid biosynthetic process
HQ865_RS23965	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HQ865_RS23980	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HQ865_RS24000	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HQ865_RS24025	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HQ865_RS24030	COG0083	homoserine kinase activity
HQ865_RS24035	COG0460	homoserine dehydrogenase
HQ865_RS24035	COG0527	aspartate kinase activity
HQ865_RS24040	COG1162	GTPase activity
HQ865_RS24045	COG1490	D-aminoacyl-tRNA deacylase activity
HQ865_RS24055	COG1694	Mazg nucleotide pyrophosphohydrolase
HQ865_RS24075	COG3119	arylsulfatase activity
HQ865_RS24085	COG1809	phosphosulfolactate synthase activity
HQ865_RS24095	COG4948	Mandelate Racemase Muconate Lactonizing
HQ865_RS24130	COG0577	efflux transmembrane transporter activity
HQ865_RS24130	COG1136	(ABC) transporter
HQ865_RS24140	COG0316	Belongs to the HesB IscA family
HQ865_RS24150	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HQ865_RS24150	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HQ865_RS24155	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HQ865_RS24170	COG1595	DNA-templated transcription, initiation
HQ865_RS24185	COG0508	dehydrogenase complex catalyzes the overall conversion of
HQ865_RS24185	COG0022	dehydrogenase e1 component
HQ865_RS24205	COG3279	Response regulator of the LytR AlgR family
HQ865_RS24210	COG3275	phosphorelay sensor kinase activity
HQ865_RS24230	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HQ865_RS24285	COG0697	spore germination
HQ865_RS24300	COG3275	phosphorelay sensor kinase activity
HQ865_RS24305	COG3279	Response regulator of the LytR AlgR family
HQ865_RS24320	COG0022	dehydrogenase e1 component
HQ865_RS24330	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HQ865_RS24360	COG2197	response regulator
HQ865_RS24385	COG2205	protein histidine kinase activity
HQ865_RS24390	COG0745	RESPONSE REGULATOR receiver
HQ865_RS24405	COG0612	Peptidase, M16
HQ865_RS24445	COG1629	transport
HQ865_RS24455	COG2843	Capsule synthesis protein
HQ865_RS24460	COG0791	NLP P60 protein
HQ865_RS24480	COG3401	FG-GAP repeat protein
HQ865_RS24485	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HQ865_RS24495	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HQ865_RS24515	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HQ865_RS24525	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HQ865_RS24525	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HQ865_RS24535	COG4232	protein-disulfide reductase activity
HQ865_RS24545	COG0205	6-phosphofructokinase activity
HQ865_RS24560	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HQ865_RS24590	COG1530	ribonuclease E activity
HQ865_RS24600	COG0776	regulation of translation
HQ865_RS24635	COG4771	TonB-dependent receptor
HQ865_RS24655	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HQ865_RS24680	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HQ865_RS24875	COG0673	inositol 2-dehydrogenase activity
HQ865_RS24895	COG4771	TonB-dependent receptor
HQ865_RS25020	COG0210	DNA helicase
HQ865_RS25025	COG4942	peptidase
HQ865_RS25050	COG4974	Belongs to the 'phage' integrase family
HQ865_RS25065	COG1192	Involved in chromosome partitioning
HQ865_RS25090	COG3285	dna ligase
HQ865_RS25090	COG1793	dna ligase
HQ865_RS25100	COG0745	RESPONSE REGULATOR receiver
HQ865_RS25105	COG3685	Protein conserved in bacteria
HQ865_RS25115	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HQ865_RS25135	COG3546	catalase activity
HQ865_RS25145	COG1546	Belongs to the CinA family
HQ865_RS25145	COG1058	Belongs to the CinA family
HQ865_RS25160	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
HQ865_RS25185	COG1028	Short-chain dehydrogenase reductase Sdr
HQ865_RS25190	COG0300	oxidoreductase activity
HQ865_RS25210	COG1028	Short-chain dehydrogenase reductase Sdr
HQ865_RS25270	COG0655	NAD(P)H dehydrogenase (quinone) activity
HQ865_RS25295	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HQ865_RS25325	COG2267	carboxylic ester hydrolase activity
HQ865_RS25355	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HQ865_RS25410	COG0156	8-amino-7-oxononanoate synthase activity
HQ865_RS25415	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HQ865_RS25420	COG0509	glycine decarboxylation via glycine cleavage system
HQ865_RS25500	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
HQ865_RS25530	COG4152	abc transporter atp-binding protein
HQ865_RS25575	COG1136	(ABC) transporter
HQ865_RS25575	COG0577	efflux transmembrane transporter activity
HQ865_RS25580	COG1136	(ABC) transporter
HQ865_RS25590	COG1914	H( )-stimulated, divalent metal cation uptake system
HQ865_RS25615	COG1612	heme a metabolic process
HQ865_RS25625	COG0720	synthase
HQ865_RS25650	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
HQ865_RS25655	COG2217	Heavy metal translocating P-type atpase
HQ865_RS25665	COG3278	Belongs to the heme-copper respiratory oxidase family
HQ865_RS25710	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HQ865_RS25715	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HQ865_RS25720	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HQ865_RS25730	COG4191	Histidine kinase
HQ865_RS25740	COG1611	Belongs to the LOG family
HQ865_RS25745	COG0427	acetyl-CoA hydrolase
HQ865_RS25750	COG5002	protein histidine kinase activity
HQ865_RS25760	COG2989	Protein conserved in bacteria
HQ865_RS25770	COG4206	TonB-dependent receptor
HQ865_RS25795	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing