locus-tag	class	description
MURRU_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
MURRU_RS00010	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MURRU_RS00015	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
MURRU_RS00025	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
MURRU_RS00035	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
MURRU_RS00040	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MURRU_RS00055	COG0336	Belongs to the RNA methyltransferase TrmD family
MURRU_RS00060	COG0335	large ribosomal subunit rRNA binding
MURRU_RS00070	COG2610	gluconate transmembrane transporter activity
MURRU_RS00085	COG1363	Peptidase, m42
MURRU_RS00095	COG0124	histidyl-tRNA synthetase
MURRU_RS00120	COG0359	binds to the 23S rRNA
MURRU_RS00125	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
MURRU_RS00130	COG0360	Binds together with S18 to 16S ribosomal RNA
MURRU_RS00135	COG3279	Response regulator of the LytR AlgR family
MURRU_RS00140	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
MURRU_RS00150	COG1295	ribonuclease BN
MURRU_RS00160	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
MURRU_RS00165	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MURRU_RS00175	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
MURRU_RS00180	COG0513	Belongs to the DEAD box helicase family
MURRU_RS00190	COG0366	Alpha amylase catalytic
MURRU_RS00220	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
MURRU_RS00240	COG0668	transmembrane transport
MURRU_RS00260	COG1595	DNA-templated transcription, initiation
MURRU_RS00280	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
MURRU_RS00330	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MURRU_RS00390	COG3279	Response regulator of the LytR AlgR family
MURRU_RS00395	COG3275	phosphorelay sensor kinase activity
MURRU_RS00410	COG0254	rRNA binding
MURRU_RS00425	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MURRU_RS00430	COG1132	(ABC) transporter
MURRU_RS00440	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MURRU_RS00440	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MURRU_RS00445	COG4221	oxidoreductase activity
MURRU_RS00465	COG1022	Amp-dependent synthetase and ligase
MURRU_RS00480	COG1024	Enoyl-CoA hydratase
MURRU_RS00480	COG1250	3-hydroxyacyl-CoA dehydrogenase
MURRU_RS00490	COG0183	Belongs to the thiolase family
MURRU_RS00500	COG1960	acyl-CoA dehydrogenase activity
MURRU_RS00505	COG3387	PFAM Glycoside hydrolase 15-related
MURRU_RS00530	COG4654	Cytochrome c, class I
MURRU_RS00540	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
MURRU_RS00560	COG1595	DNA-templated transcription, initiation
MURRU_RS00570	COG0598	Magnesium transport protein CorA
MURRU_RS00600	COG3279	Response regulator of the LytR AlgR family
MURRU_RS00635	COG3275	phosphorelay sensor kinase activity
MURRU_RS00645	COG2808	Putative FMN-binding domain
MURRU_RS00655	COG0456	acetyltransferase
MURRU_RS00655	COG0454	-acetyltransferase
MURRU_RS00690	COG0494	nUDIX hydrolase
MURRU_RS00750	COG4948	Mandelate Racemase Muconate Lactonizing
MURRU_RS00755	COG0156	8-amino-7-oxononanoate synthase activity
MURRU_RS00770	COG4771	TonB-dependent receptor
MURRU_RS00780	COG0492	ferredoxin-NADP+ reductase activity
MURRU_RS00785	COG0189	ligase activity
MURRU_RS00785	COG4067	protein conserved in archaea
MURRU_RS00805	COG0010	Belongs to the arginase family
MURRU_RS00815	COG2010	Cytochrome c
MURRU_RS00815	COG1529	Aldehyde oxidase and xanthine dehydrogenase
MURRU_RS00860	COG2378	regulation of single-species biofilm formation
MURRU_RS00895	COG2207	Transcriptional regulator
MURRU_RS00895	COG4753	response regulator
MURRU_RS00900	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
MURRU_RS00935	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MURRU_RS00945	COG0828	Belongs to the bacterial ribosomal protein bS21 family
MURRU_RS00975	COG3275	phosphorelay sensor kinase activity
MURRU_RS00980	COG3279	Response regulator of the LytR AlgR family
MURRU_RS01005	COG1131	(ABC) transporter
MURRU_RS01010	COG1131	(ABC) transporter
MURRU_RS01015	COG0842	Transport permease protein
MURRU_RS01020	COG0842	Transport permease protein
MURRU_RS01020	COG1129	ABC transporter
MURRU_RS01025	COG1611	Belongs to the LOG family
MURRU_RS01055	COG0659	secondary active sulfate transmembrane transporter activity
MURRU_RS01065	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
MURRU_RS01070	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
MURRU_RS01110	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
MURRU_RS01150	COG4974	Belongs to the 'phage' integrase family
MURRU_RS01160	COG2133	pyrroloquinoline quinone binding
MURRU_RS01165	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
MURRU_RS01170	COG1349	DNA-binding transcription factor activity
MURRU_RS01175	COG0363	glucosamine-6-phosphate deaminase activity
MURRU_RS01185	COG1472	Belongs to the glycosyl hydrolase 3 family
MURRU_RS01190	COG2226	methyltransferase
MURRU_RS01200	COG2814	Major facilitator Superfamily
MURRU_RS01210	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
MURRU_RS01215	COG0439	Biotin carboxylase
MURRU_RS01220	COG0511	ligase activity, forming carbon-carbon bonds
MURRU_RS01225	COG0572	uridine kinase
MURRU_RS01235	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
MURRU_RS01240	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
MURRU_RS01240	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
MURRU_RS01245	COG1192	Involved in chromosome partitioning
MURRU_RS01250	COG1475	DNA binding
MURRU_RS01260	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
MURRU_RS01265	COG0681	Belongs to the peptidase S26 family
MURRU_RS01295	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
MURRU_RS01305	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
MURRU_RS01315	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
MURRU_RS01330	COG0105	UTP biosynthetic process
MURRU_RS01340	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
MURRU_RS01350	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
MURRU_RS01360	COG1228	amidohydrolase
MURRU_RS01375	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MURRU_RS01385	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MURRU_RS01390	COG0735	belongs to the Fur family
MURRU_RS01395	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
MURRU_RS01400	COG0783	Belongs to the Dps family
MURRU_RS01410	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MURRU_RS01430	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
MURRU_RS01440	COG0517	IMP dehydrogenase activity
MURRU_RS01440	COG0516	GMP reductase activity
MURRU_RS01445	COG1418	mRNA catabolic process
MURRU_RS01500	COG0514	ATP-dependent DNA helicase (RecQ)
MURRU_RS01505	COG0517	IMP dehydrogenase activity
MURRU_RS01505	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
MURRU_RS01510	COG0805	protein transport
MURRU_RS01520	COG1137	ATPase activity
MURRU_RS01525	COG1183	phosphatidylcholine synthase activity
MURRU_RS01535	COG0488	(ABC) transporter
MURRU_RS01555	COG0653	protein targeting
MURRU_RS01570	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MURRU_RS01585	COG1595	DNA-templated transcription, initiation
MURRU_RS01590	COG1764	response to oxidative stress
MURRU_RS01600	COG0463	Glycosyl transferase, family 2
MURRU_RS01610	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
MURRU_RS01615	COG0671	phosphoesterase, PA-phosphatase related
MURRU_RS01625	COG0534	Mate efflux family protein
MURRU_RS01630	COG3956	TIGRFAM MazG family protein
MURRU_RS01655	COG0242	peptide deformylase activity
MURRU_RS01660	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
MURRU_RS01665	COG2171	N-acyltransferase activity
MURRU_RS01670	COG0438	transferase activity, transferring glycosyl groups
MURRU_RS01675	COG0562	UDP-galactopyranose mutase
MURRU_RS01685	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
MURRU_RS01685	COG0463	Glycosyl transferase, family 2
MURRU_RS01695	COG0009	L-threonylcarbamoyladenylate synthase
MURRU_RS01700	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
MURRU_RS01700	COG0517	IMP dehydrogenase activity
MURRU_RS01700	COG0617	tRNA 3'-terminal CCA addition
MURRU_RS01705	COG1612	heme a metabolic process
MURRU_RS01725	COG1131	(ABC) transporter
MURRU_RS01735	COG0556	nucleotide-excision repair
MURRU_RS01740	COG0071	Belongs to the small heat shock protein (HSP20) family
MURRU_RS01755	COG0045	succinate-CoA ligase (ADP-forming) activity
MURRU_RS01765	COG0019	diaminopimelate decarboxylase activity
MURRU_RS01775	COG0516	GMP reductase activity
MURRU_RS01775	COG0517	IMP dehydrogenase activity
MURRU_RS01805	COG0167	dihydroorotate dehydrogenase activity
MURRU_RS01815	COG2195	Cleaves the N-terminal amino acid of tripeptides
MURRU_RS01850	COG2326	polyphosphate kinase activity
MURRU_RS01860	COG2204	response regulator
MURRU_RS01870	COG3264	Mechanosensitive ion channel
MURRU_RS01870	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
MURRU_RS01875	COG1668	transmembrane transport
MURRU_RS01880	COG4152	abc transporter atp-binding protein
MURRU_RS01885	COG0484	heat shock protein binding
MURRU_RS01890	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
MURRU_RS01895	COG1090	epimerase
MURRU_RS01910	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MURRU_RS01930	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MURRU_RS01935	COG0347	Belongs to the P(II) protein family
MURRU_RS01940	COG0004	ammonium transporteR
MURRU_RS01960	COG1522	sequence-specific DNA binding
MURRU_RS01970	COG1703	isobutyryl-CoA mutase activity
MURRU_RS01970	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
MURRU_RS01970	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
MURRU_RS01975	COG0788	formyltetrahydrofolate deformylase activity
MURRU_RS01985	COG1554	hydrolase, family 65, central catalytic
MURRU_RS02005	COG0284	orotidine-5'-phosphate decarboxylase activity
MURRU_RS02010	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
MURRU_RS02025	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MURRU_RS02035	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
MURRU_RS02045	COG0174	glutamine synthetase
MURRU_RS02070	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MURRU_RS02080	COG3119	arylsulfatase activity
MURRU_RS02085	COG1262	PFAM Formylglycine-generating sulfatase enzyme
MURRU_RS02100	COG0589	response to stress
MURRU_RS02120	COG1136	(ABC) transporter
MURRU_RS02130	COG0071	Belongs to the small heat shock protein (HSP20) family
MURRU_RS02135	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
MURRU_RS02145	COG0745	RESPONSE REGULATOR receiver
MURRU_RS02155	COG1127	ABC transporter
MURRU_RS02160	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
MURRU_RS02180	COG0589	response to stress
MURRU_RS02225	COG0574	Belongs to the PEP-utilizing enzyme family
MURRU_RS02225	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MURRU_RS02235	COG1028	Short-chain dehydrogenase reductase Sdr
MURRU_RS02250	COG0716	FMN binding
MURRU_RS02305	COG2264	protein methyltransferase activity
MURRU_RS02310	COG0149	triose-phosphate isomerase activity
MURRU_RS02325	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
MURRU_RS02350	COG1132	(ABC) transporter
MURRU_RS02355	COG0101	tRNA pseudouridine synthase activity
MURRU_RS02390	COG0268	Binds directly to 16S ribosomal RNA
MURRU_RS02405	COG0442	prolyl-tRNA aminoacylation
MURRU_RS02435	COG0302	gtp cyclohydrolase
MURRU_RS02440	COG0215	cysteine-tRNA ligase activity
MURRU_RS02445	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
MURRU_RS02450	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
MURRU_RS02465	COG1119	ATPase activity
MURRU_RS02475	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MURRU_RS02495	COG0187	DNA topoisomerase II activity
MURRU_RS02500	COG0367	asparagine synthase
MURRU_RS02510	COG1574	metal-dependent hydrolase with the TIM-barrel fold
MURRU_RS02525	COG1704	LemA family
MURRU_RS02535	COG2884	Cell division ATP-binding protein ftsE
MURRU_RS02545	COG1217	gtp-binding protein TYPA
MURRU_RS02565	COG2877	3-deoxy-8-phosphooctulonate synthase activity
MURRU_RS02600	COG2354	Protein conserved in bacteria
MURRU_RS02655	COG0471	metal ion transport
MURRU_RS02670	COG1629	transport
MURRU_RS02670	COG4206	TonB-dependent receptor
MURRU_RS02680	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
MURRU_RS02695	COG1346	cytolysis
MURRU_RS02700	COG1380	Effector of murein hydrolase LrgA
MURRU_RS02705	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MURRU_RS02710	COG3525	Glycosyl hydrolase, family 20, catalytic domain
MURRU_RS02725	COG2186	Transcriptional regulator
MURRU_RS02730	COG0702	epimerase
MURRU_RS02735	COG4771	TonB-dependent receptor
MURRU_RS02765	COG0702	epimerase
MURRU_RS02770	COG4771	TonB-dependent receptor
MURRU_RS02795	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
MURRU_RS02805	COG0702	epimerase
MURRU_RS02810	COG1629	transport
MURRU_RS02820	COG3250	beta-galactosidase activity
MURRU_RS02830	COG1262	PFAM Formylglycine-generating sulfatase enzyme
MURRU_RS02830	COG0515	serine threonine protein kinase
MURRU_RS02845	COG0513	Belongs to the DEAD box helicase family
MURRU_RS02850	COG1278	Cold shock
MURRU_RS02855	COG1278	Cold shock
MURRU_RS02865	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
MURRU_RS02875	COG5183	chlorophyll binding
MURRU_RS02875	COG2133	pyrroloquinoline quinone binding
MURRU_RS02885	COG4771	TonB-dependent receptor
MURRU_RS02900	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MURRU_RS02920	COG3118	belongs to the thioredoxin family
MURRU_RS02945	COG2160	L-arabinose isomerase activity
MURRU_RS02995	COG1506	peptidase
MURRU_RS02995	COG0823	Involved in the tonB-independent uptake of proteins
MURRU_RS03000	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MURRU_RS03005	COG3938	Belongs to the proline racemase family
MURRU_RS03015	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MURRU_RS03025	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
MURRU_RS03030	COG4771	TonB-dependent receptor
MURRU_RS03050	COG0577	efflux transmembrane transporter activity
MURRU_RS03055	COG3876	Protein conserved in bacteria
MURRU_RS03080	COG0602	queuosine metabolic process
MURRU_RS03090	COG0433	COG0433 Predicted ATPase
MURRU_RS03100	COG1733	regulation of RNA biosynthetic process
MURRU_RS03120	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
MURRU_RS03125	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MURRU_RS03155	COG2852	Protein conserved in bacteria
MURRU_RS03160	COG0018	arginyl-trna synthetase
MURRU_RS03170	COG0702	epimerase
MURRU_RS03205	COG0148	phosphopyruvate hydratase activity
MURRU_RS03210	COG0505	Belongs to the CarA family
MURRU_RS03215	COG0203	ribosomal protein L17
MURRU_RS03220	COG0202	RNA polymerase activity
MURRU_RS03225	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
MURRU_RS03230	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
MURRU_RS03235	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
MURRU_RS03240	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
MURRU_RS03250	COG0200	Binds to the 23S rRNA
MURRU_RS03255	COG1841	ribosomal large subunit assembly
MURRU_RS03260	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
MURRU_RS03270	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
MURRU_RS03275	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
MURRU_RS03280	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
MURRU_RS03285	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
MURRU_RS03290	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
MURRU_RS03295	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
MURRU_RS03300	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
MURRU_RS03305	COG0255	Belongs to the universal ribosomal protein uL29 family
MURRU_RS03310	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
MURRU_RS03315	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
MURRU_RS03320	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
MURRU_RS03325	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
MURRU_RS03330	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
MURRU_RS03335	COG0089	rRNA binding
MURRU_RS03340	COG0088	Forms part of the polypeptide exit tunnel
MURRU_RS03345	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
MURRU_RS03350	COG0051	transcription antitermination factor activity, RNA binding
MURRU_RS03355	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MURRU_RS03360	COG0049	tRNA binding
MURRU_RS03365	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
MURRU_RS03370	COG1629	transport
MURRU_RS03395	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MURRU_RS03405	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
MURRU_RS03425	COG1011	Hydrolase
MURRU_RS03435	COG2003	Belongs to the UPF0758 family
MURRU_RS03445	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
MURRU_RS03465	COG3279	Response regulator of the LytR AlgR family
MURRU_RS03470	COG3275	phosphorelay sensor kinase activity
MURRU_RS03485	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MURRU_RS03490	COG0563	adenylate kinase activity
MURRU_RS03495	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
MURRU_RS03500	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
MURRU_RS03510	COG0339	signal peptide processing
MURRU_RS03520	COG2201	protein-glutamate methylesterase activity
MURRU_RS03540	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MURRU_RS03540	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MURRU_RS03545	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MURRU_RS03555	COG1216	Glycosyl transferase, family 2
MURRU_RS03575	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
MURRU_RS03580	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
MURRU_RS03585	COG1127	ABC transporter
MURRU_RS03610	COG1028	Short-chain dehydrogenase reductase Sdr
MURRU_RS03615	COG2234	aminopeptidase activity
MURRU_RS03625	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
MURRU_RS03645	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
MURRU_RS03665	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
MURRU_RS03710	COG2801	Transposase and inactivated derivatives
MURRU_RS03710	COG3415	Transposase
MURRU_RS03715	COG2963	transposase activity
MURRU_RS03730	COG0285	dihydrofolate synthase activity
MURRU_RS03740	COG0848	biopolymer transport protein
MURRU_RS03745	COG0811	peptide transport
MURRU_RS03755	COG1960	acyl-CoA dehydrogenase activity
MURRU_RS03760	COG0067	glutamate synthase
MURRU_RS03760	COG0069	glutamate synthase activity
MURRU_RS03760	COG0070	glutamate synthase
MURRU_RS03810	COG1629	transport
MURRU_RS03810	COG4206	TonB-dependent receptor
MURRU_RS03815	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
MURRU_RS03860	COG0321	lipoyl(octanoyl) transferase activity
MURRU_RS03870	COG2197	response regulator
MURRU_RS03875	COG3118	belongs to the thioredoxin family
MURRU_RS03880	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
MURRU_RS03885	COG1629	transport
MURRU_RS03885	COG4206	TonB-dependent receptor
MURRU_RS03890	COG0471	metal ion transport
MURRU_RS03965	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
MURRU_RS03980	COG2515	1-aminocyclopropane-1-carboxylate deaminase
MURRU_RS04020	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MURRU_RS04025	COG4942	peptidase
MURRU_RS04035	COG1704	LemA family
MURRU_RS04045	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
MURRU_RS04060	COG4953	penicillin-binding protein 1C
MURRU_RS04070	COG1160	GTP binding
MURRU_RS04080	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
MURRU_RS04085	COG1115	amino acid carrier protein
MURRU_RS04105	COG1629	transport
MURRU_RS04125	COG2814	Major facilitator Superfamily
MURRU_RS04160	COG0488	(ABC) transporter
MURRU_RS04190	COG1262	PFAM Formylglycine-generating sulfatase enzyme
MURRU_RS04205	COG4447	cellulose binding
MURRU_RS04215	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MURRU_RS04220	COG3604	Transcriptional regulator
MURRU_RS04240	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
MURRU_RS04245	COG0459	protein refolding
MURRU_RS04260	COG2217	Heavy metal translocating P-type atpase
MURRU_RS04280	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MURRU_RS04295	COG0138	bifunctional purine biosynthesis protein purh
MURRU_RS04300	COG1077	Cell shape determining protein MreB Mrl
MURRU_RS04320	COG0772	Belongs to the SEDS family
MURRU_RS04330	COG0793	Belongs to the peptidase S41A family
MURRU_RS04335	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
MURRU_RS04345	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MURRU_RS04350	COG0791	NLP P60 protein
MURRU_RS04355	COG0658	competence protein
MURRU_RS04355	COG2333	competence protein COMEC
MURRU_RS04390	COG4771	TonB-dependent receptor
MURRU_RS04410	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MURRU_RS04440	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
MURRU_RS04495	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MURRU_RS04525	COG1621	beta-fructofuranosidase activity
MURRU_RS04535	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
MURRU_RS04540	COG2226	methyltransferase
MURRU_RS04560	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MURRU_RS04575	COG1215	transferase activity, transferring glycosyl groups
MURRU_RS04590	COG0137	argininosuccinate synthase activity
MURRU_RS04595	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
MURRU_RS04600	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
MURRU_RS04605	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MURRU_RS04610	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
MURRU_RS04615	COG1028	Short-chain dehydrogenase reductase Sdr
MURRU_RS04620	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
MURRU_RS04625	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MURRU_RS04630	COG0165	Argininosuccinate lyase
MURRU_RS04650	COG2161	toxin-antitoxin pair type II binding
MURRU_RS04655	COG4115	mRNA cleavage
MURRU_RS04660	COG1187	pseudouridine synthase activity
MURRU_RS04680	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
MURRU_RS04695	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
MURRU_RS04700	COG2081	HI0933 family
MURRU_RS04705	COG0584	glycerophosphoryl diester phosphodiesterase
MURRU_RS04715	COG1609	Transcriptional regulator
MURRU_RS04720	COG1629	transport
MURRU_RS04720	COG4206	TonB-dependent receptor
MURRU_RS04725	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
MURRU_RS04760	COG0514	ATP-dependent DNA helicase (RecQ)
MURRU_RS04805	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
MURRU_RS04810	COG1132	(ABC) transporter
MURRU_RS04820	COG0633	Ferredoxin
MURRU_RS04825	COG0492	ferredoxin-NADP+ reductase activity
MURRU_RS04835	COG0489	protein tyrosine kinase activity
MURRU_RS04840	COG0154	amidase activity
MURRU_RS04855	COG0220	tRNA (guanine-N7-)-methyltransferase activity
MURRU_RS04865	COG5002	protein histidine kinase activity
MURRU_RS04870	COG0745	RESPONSE REGULATOR receiver
MURRU_RS04880	COG1629	transport
MURRU_RS04880	COG4206	TonB-dependent receptor
MURRU_RS04900	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
MURRU_RS04915	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
MURRU_RS04920	COG0463	Glycosyl transferase, family 2
MURRU_RS04940	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
MURRU_RS04945	COG2363	Small membrane protein
MURRU_RS04955	COG1522	sequence-specific DNA binding
MURRU_RS04965	COG1528	Iron-storage protein
MURRU_RS04990	COG0495	leucyl-tRNA aminoacylation
MURRU_RS04995	COG2177	Part of the ABC transporter FtsEX involved in
MURRU_RS05005	COG1968	undecaprenyl-diphosphatase activity
MURRU_RS05010	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
MURRU_RS05035	COG2274	protein secretion by the type I secretion system
MURRU_RS05045	COG0519	Catalyzes the synthesis of GMP from XMP
MURRU_RS05050	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
MURRU_RS05060	COG5000	phosphorelay sensor kinase activity
MURRU_RS05075	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
MURRU_RS05085	COG0667	Aldo Keto reductase
MURRU_RS05095	COG3850	Histidine kinase
MURRU_RS05095	COG4999	Histidine kinase
MURRU_RS05095	COG2205	protein histidine kinase activity
MURRU_RS05095	COG3437	response regulator, receiver
MURRU_RS05140	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
MURRU_RS05165	COG0211	Belongs to the bacterial ribosomal protein bL27 family
MURRU_RS05170	COG0261	This protein binds to 23S rRNA in the presence of protein L20
MURRU_RS05215	COG0629	single-stranded DNA binding
MURRU_RS05225	COG0776	regulation of translation
MURRU_RS05230	COG1530	ribonuclease E activity
MURRU_RS05265	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
MURRU_RS05300	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
MURRU_RS05305	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
MURRU_RS05310	COG0297	glycogen (starch) synthase activity
MURRU_RS05320	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
MURRU_RS05340	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
MURRU_RS05345	COG4993	Dehydrogenase
MURRU_RS05350	COG0667	Aldo Keto reductase
MURRU_RS05355	COG0708	Exodeoxyribonuclease III
MURRU_RS05360	COG1335	isochorismatase
MURRU_RS05390	COG2759	Belongs to the formate--tetrahydrofolate ligase family
MURRU_RS05395	COG0423	glycine-tRNA ligase activity
MURRU_RS05405	COG1040	competence protein
MURRU_RS05415	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MURRU_RS05425	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
MURRU_RS05480	COG4771	TonB-dependent receptor
MURRU_RS05485	COG0166	Belongs to the GPI family
MURRU_RS05495	COG3483	tryptophan 2,3-dioxygenase activity
MURRU_RS05505	COG1752	Esterase of the alpha-beta hydrolase superfamily
MURRU_RS05510	COG0322	excinuclease ABC activity
MURRU_RS05520	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
MURRU_RS05525	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
MURRU_RS05540	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
MURRU_RS05555	COG1381	Involved in DNA repair and RecF pathway recombination
MURRU_RS05560	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
MURRU_RS05565	COG0626	cystathionine gamma-synthase activity
MURRU_RS05615	COG2070	2-Nitropropane dioxygenase
MURRU_RS05620	COG0429	hydrolase of the alpha beta-hydrolase fold
MURRU_RS05635	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
MURRU_RS05660	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
MURRU_RS05710	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
MURRU_RS05715	COG2329	Antibiotic biosynthesis monooxygenase
MURRU_RS05745	COG1012	belongs to the aldehyde dehydrogenase family
MURRU_RS05765	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MURRU_RS05775	COG4221	oxidoreductase activity
MURRU_RS05780	COG4989	oxidoreductase activity
MURRU_RS05785	COG0714	Associated with various cellular activities
MURRU_RS05800	COG2304	oxidoreductase activity
MURRU_RS05805	COG2304	oxidoreductase activity
MURRU_RS05830	COG0659	secondary active sulfate transmembrane transporter activity
MURRU_RS05840	COG0659	secondary active sulfate transmembrane transporter activity
MURRU_RS05850	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
MURRU_RS05880	COG1309	transcriptional regulator
MURRU_RS05890	COG1396	sequence-specific DNA binding
MURRU_RS05905	COG2954	triphosphatase activity
MURRU_RS05910	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MURRU_RS05915	COG0612	Peptidase, M16
MURRU_RS05925	COG0469	pyruvate kinase activity
MURRU_RS05935	COG0571	ribonuclease III activity
MURRU_RS05940	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MURRU_RS05945	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MURRU_RS05955	COG0328	RNA-DNA hybrid ribonuclease activity
MURRU_RS05955	COG3341	Caulimovirus viroplasmin
MURRU_RS05980	COG1074	ATP-dependent DNA helicase activity
MURRU_RS05985	COG0156	8-amino-7-oxononanoate synthase activity
MURRU_RS06000	COG1028	Short-chain dehydrogenase reductase Sdr
MURRU_RS06015	COG0564	pseudouridine synthase activity
MURRU_RS06035	COG0534	Mate efflux family protein
MURRU_RS06040	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
MURRU_RS06055	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MURRU_RS06060	COG2211	Major facilitator Superfamily
MURRU_RS06065	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
MURRU_RS06065	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
MURRU_RS06070	COG2827	Endonuclease containing a URI domain
MURRU_RS06080	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
MURRU_RS06085	COG1573	uracil-dna glycosylase
MURRU_RS06115	COG1476	TRANSCRIPTIONal
MURRU_RS06120	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
MURRU_RS06130	COG1435	thymidine kinase activity
MURRU_RS06140	COG1970	mechanosensitive ion channel activity
MURRU_RS06145	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
MURRU_RS06160	COG1505	serine-type exopeptidase activity
MURRU_RS06170	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
MURRU_RS06205	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
MURRU_RS06215	COG0333	Belongs to the bacterial ribosomal protein bL32 family
MURRU_RS06220	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MURRU_RS06225	COG0511	ligase activity, forming carbon-carbon bonds
MURRU_RS06230	COG0439	Biotin carboxylase
MURRU_RS06240	COG1136	(ABC) transporter
MURRU_RS06245	COG1136	(ABC) transporter
MURRU_RS06245	COG0577	efflux transmembrane transporter activity
MURRU_RS06250	COG0577	efflux transmembrane transporter activity
MURRU_RS06255	COG0577	efflux transmembrane transporter activity
MURRU_RS06255	COG1136	(ABC) transporter
MURRU_RS06260	COG0577	efflux transmembrane transporter activity
MURRU_RS06270	COG1136	(ABC) transporter
MURRU_RS06270	COG0577	efflux transmembrane transporter activity
MURRU_RS06290	COG5000	phosphorelay sensor kinase activity
MURRU_RS06300	COG2382	esterase
MURRU_RS06325	COG2204	response regulator
MURRU_RS06330	COG5002	protein histidine kinase activity
MURRU_RS06335	COG3693	PFAM glycoside hydrolase, family 10
MURRU_RS06335	COG2382	esterase
MURRU_RS06345	COG0346	lactoylglutathione lyase activity
MURRU_RS06350	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
MURRU_RS06370	COG0481	GTPase activity
MURRU_RS06380	COG0471	metal ion transport
MURRU_RS06380	COG3273	potassium ion transport
MURRU_RS06390	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MURRU_RS06395	COG1404	Belongs to the peptidase S8 family
MURRU_RS06395	COG1404	Belongs to the peptidase S8 family
MURRU_RS06415	COG0594	ribonuclease P activity
MURRU_RS06420	COG0793	Belongs to the peptidase S41A family
MURRU_RS06455	COG2153	protein acetylation
MURRU_RS06465	COG0698	ribose 5-phosphate isomerase
MURRU_RS06470	COG0557	exoribonuclease II activity
MURRU_RS06515	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MURRU_RS06540	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MURRU_RS06550	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
MURRU_RS06555	COG0445	tRNA wobble uridine modification
MURRU_RS06605	COG0126	phosphoglycerate kinase activity
MURRU_RS06610	COG1388	LysM domain
MURRU_RS06610	COG3942	CHAP domain
MURRU_RS06620	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
MURRU_RS06620	COG2885	chlorophyll binding
MURRU_RS06625	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MURRU_RS06630	COG4942	peptidase
MURRU_RS06650	COG1091	dTDP-4-dehydrorhamnose reductase activity
MURRU_RS06680	COG0529	Catalyzes the synthesis of activated sulfate
MURRU_RS06685	COG0175	sulfate reduction
MURRU_RS06705	COG2244	polysaccharide biosynthetic process
MURRU_RS06710	COG1045	serine acetyltransferase
MURRU_RS06735	COG0297	glycogen (starch) synthase activity
MURRU_RS06735	COG0438	transferase activity, transferring glycosyl groups
MURRU_RS06745	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MURRU_RS06750	COG0151	Belongs to the GarS family
MURRU_RS06770	COG0859	PFAM glycosyl transferase family 9
MURRU_RS06795	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
MURRU_RS06800	COG1752	Esterase of the alpha-beta hydrolase superfamily
MURRU_RS06805	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
MURRU_RS06805	COG1017	nitric oxide dioxygenase activity
MURRU_RS06840	COG0356	it plays a direct role in the translocation of protons across the membrane
MURRU_RS06845	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MURRU_RS06850	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
MURRU_RS06855	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MURRU_RS06860	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
MURRU_RS06870	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
MURRU_RS06880	COG0756	dUTP diphosphatase activity
MURRU_RS06885	COG1210	Utp--glucose-1-phosphate uridylyltransferase
MURRU_RS06905	COG0656	L-ascorbic acid biosynthetic process
MURRU_RS06925	COG4260	virion core protein, lumpy skin disease virus
MURRU_RS06940	COG0673	inositol 2-dehydrogenase activity
MURRU_RS06950	COG4447	cellulose binding
MURRU_RS06960	COG1981	membrane
MURRU_RS06995	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
MURRU_RS07000	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
MURRU_RS07010	COG1774	PSP1 C-terminal conserved region
MURRU_RS07020	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
MURRU_RS07045	COG3275	phosphorelay sensor kinase activity
MURRU_RS07060	COG0180	Tryptophanyl-tRNA synthetase
MURRU_RS07080	COG1024	Enoyl-CoA hydratase
MURRU_RS07085	COG5000	phosphorelay sensor kinase activity
MURRU_RS07100	COG1053	succinate dehydrogenase
MURRU_RS07110	COG0189	ligase activity
MURRU_RS07125	COG0006	proline dipeptidase activity
MURRU_RS07130	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
MURRU_RS07155	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
MURRU_RS07160	COG0316	Belongs to the HesB IscA family
MURRU_RS07165	COG0719	Fe-S assembly protein
MURRU_RS07170	COG0396	ATPase activity
MURRU_RS07180	COG0719	Fe-S assembly protein
MURRU_RS07190	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MURRU_RS07195	COG2166	iron-sulfur cluster assembly
MURRU_RS07200	COG2151	metal-sulfur cluster biosynthetic enzyme
MURRU_RS07235	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MURRU_RS07260	COG1253	flavin adenine dinucleotide binding
MURRU_RS07265	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
MURRU_RS07280	COG0113	porphobilinogen synthase activity
MURRU_RS07300	COG0408	coproporphyrinogen oxidase activity
MURRU_RS07310	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
MURRU_RS07320	COG0181	hydroxymethylbilane synthase activity
MURRU_RS07325	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
MURRU_RS07350	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
MURRU_RS07360	COG2706	6-phosphogluconolactonase activity
MURRU_RS07375	COG1506	peptidase
MURRU_RS07390	COG1418	mRNA catabolic process
MURRU_RS07425	COG0793	Belongs to the peptidase S41A family
MURRU_RS07435	COG2095	MarC family integral membrane protein
MURRU_RS07445	COG2972	Histidine kinase
MURRU_RS07450	COG3279	Response regulator of the LytR AlgR family
MURRU_RS07470	COG2318	DinB family
MURRU_RS07475	COG2211	Major facilitator Superfamily
MURRU_RS07485	COG0673	inositol 2-dehydrogenase activity
MURRU_RS07510	COG1561	YicC-like family, N-terminal region
MURRU_RS07515	COG0194	GDP metabolic process
MURRU_RS07520	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
MURRU_RS07545	COG0232	Belongs to the dGTPase family. Type 2 subfamily
MURRU_RS07555	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
MURRU_RS07560	COG0590	tRNA wobble adenosine to inosine editing
MURRU_RS07565	COG1278	Cold shock
MURRU_RS07580	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
MURRU_RS07590	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MURRU_RS07595	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MURRU_RS07605	COG1309	transcriptional regulator
MURRU_RS07630	COG2361	Protein of unknown function DUF86
MURRU_RS07640	COG4771	TonB-dependent receptor
MURRU_RS07685	COG1028	Short-chain dehydrogenase reductase Sdr
MURRU_RS07700	COG2363	Small membrane protein
MURRU_RS07735	COG1999	signal sequence binding
MURRU_RS07740	COG0750	zinc metalloprotease
MURRU_RS07755	COG0450	alkyl hydroperoxide reductase
MURRU_RS07765	COG0783	Belongs to the Dps family
MURRU_RS07770	COG1271	oxidase subunit
MURRU_RS07775	COG1294	oxidase, subunit
MURRU_RS07785	COG2197	response regulator
MURRU_RS07850	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MURRU_RS07850	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MURRU_RS07870	COG1070	Carbohydrate kinase
MURRU_RS07875	COG2115	Belongs to the xylose isomerase family
MURRU_RS07880	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MURRU_RS07895	COG2353	YceI-like domain
MURRU_RS07925	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MURRU_RS07945	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MURRU_RS07985	COG1929	Belongs to the glycerate kinase type-1 family
MURRU_RS08000	COG0783	Belongs to the Dps family
MURRU_RS08010	COG0629	single-stranded DNA binding
MURRU_RS08030	COG0123	including yeast histone deacetylase and acetoin utilization protein
MURRU_RS08040	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MURRU_RS08040	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MURRU_RS08055	COG0792	nuclease activity
MURRU_RS08080	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
MURRU_RS08090	COG1201	RNA secondary structure unwinding
MURRU_RS08100	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
MURRU_RS08110	COG0527	aspartate kinase activity
MURRU_RS08120	COG0456	acetyltransferase
MURRU_RS08140	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MURRU_RS08155	COG2239	Acts as a magnesium transporter
MURRU_RS08160	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
MURRU_RS08180	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
MURRU_RS08190	COG0196	riboflavin kinase activity
MURRU_RS08195	COG1404	Belongs to the peptidase S8 family
MURRU_RS08195	COG4935	Belongs to the peptidase S8 family
MURRU_RS08205	COG0193	aminoacyl-tRNA hydrolase activity
MURRU_RS08210	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
MURRU_RS08215	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
MURRU_RS08230	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MURRU_RS08245	COG1648	precorrin-2 dehydrogenase activity
MURRU_RS08245	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MURRU_RS08250	COG3279	Response regulator of the LytR AlgR family
MURRU_RS08255	COG3275	phosphorelay sensor kinase activity
MURRU_RS08295	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
MURRU_RS08300	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
MURRU_RS08305	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MURRU_RS08315	COG0828	Belongs to the bacterial ribosomal protein bS21 family
MURRU_RS08410	COG3118	belongs to the thioredoxin family
MURRU_RS08425	COG0228	four-way junction DNA binding
MURRU_RS08430	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
MURRU_RS08440	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
MURRU_RS08445	COG1960	acyl-CoA dehydrogenase activity
MURRU_RS08460	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
MURRU_RS08465	COG0010	Belongs to the arginase family
MURRU_RS08470	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
MURRU_RS08475	COG1228	amidohydrolase
MURRU_RS08480	COG2986	histidine ammonia-lyase
MURRU_RS08485	COG0583	DNA-binding transcription factor activity
MURRU_RS08495	COG2839	Protein conserved in bacteria
MURRU_RS08505	COG4206	TonB-dependent receptor
MURRU_RS08530	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
MURRU_RS08535	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MURRU_RS08560	COG2315	Protein conserved in bacteria
MURRU_RS08565	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
MURRU_RS08585	COG2824	Alkylphosphonate utilization operon protein PhnA
MURRU_RS08705	COG3850	Histidine kinase
MURRU_RS08705	COG5002	protein histidine kinase activity
MURRU_RS08710	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
MURRU_RS08720	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MURRU_RS08735	COG3278	Belongs to the heme-copper respiratory oxidase family
MURRU_RS08745	COG2010	Cytochrome c
MURRU_RS08750	COG0348	domain, Protein
MURRU_RS08765	COG0427	acetyl-CoA hydrolase
MURRU_RS08770	COG0589	response to stress
MURRU_RS08775	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MURRU_RS08795	COG1940	carbohydrate kinase activity
MURRU_RS08820	COG2814	Major facilitator Superfamily
MURRU_RS08825	COG1519	Transferase
MURRU_RS08835	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
MURRU_RS08850	COG0567	Dehydrogenase, E1 component
MURRU_RS08855	COG0508	dehydrogenase complex catalyzes the overall conversion of
MURRU_RS08865	COG0084	hydrolase, TatD family'
MURRU_RS08870	COG0252	asparaginase activity
MURRU_RS08880	COG0811	peptide transport
MURRU_RS08915	COG0017	Asparaginyl-tRNA synthetase
MURRU_RS08925	COG0233	cytoplasmic translational termination
MURRU_RS08930	COG0528	UMP kinase activity
MURRU_RS08935	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
MURRU_RS08940	COG0052	Belongs to the universal ribosomal protein uS2 family
MURRU_RS08945	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
MURRU_RS08950	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
MURRU_RS08975	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MURRU_RS08985	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
MURRU_RS08990	COG3185	4-Hydroxyphenylpyruvate dioxygenase
MURRU_RS09010	COG0793	Belongs to the peptidase S41A family
MURRU_RS09010	COG4946	Tricorn protease homolog
MURRU_RS09035	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MURRU_RS09035	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MURRU_RS09040	COG1446	asparaginase
MURRU_RS09085	COG0779	Required for maturation of 30S ribosomal subunits
MURRU_RS09090	COG0195	Participates in both transcription termination and antitermination
MURRU_RS09090	COG2251	uridine kinase activity
MURRU_RS09095	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
MURRU_RS09110	COG0437	4 iron, 4 sulfur cluster binding
MURRU_RS09125	COG3258	Cytochrome c
MURRU_RS09135	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
MURRU_RS09140	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
MURRU_RS09155	COG2255	four-way junction helicase activity
MURRU_RS09160	COG3258	Cytochrome c
MURRU_RS09175	COG2827	Endonuclease containing a URI domain
MURRU_RS09180	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
MURRU_RS09185	COG0280	phosphate acetyltransferase
MURRU_RS09185	COG0281	malic enzyme
MURRU_RS09190	COG0632	four-way junction helicase activity
MURRU_RS09200	COG0509	glycine decarboxylation via glycine cleavage system
MURRU_RS09215	COG0109	protoheme IX farnesyltransferase activity
MURRU_RS09220	COG1845	cytochrome c oxidase, subunit III
MURRU_RS09240	COG1999	signal sequence binding
MURRU_RS09245	COG2322	membrane
MURRU_RS09255	COG1136	(ABC) transporter
MURRU_RS09260	COG0577	efflux transmembrane transporter activity
MURRU_RS09260	COG1136	(ABC) transporter
MURRU_RS09270	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MURRU_RS09280	COG1214	PFAM Peptidase M22, glycoprotease
MURRU_RS09285	COG0668	transmembrane transport
MURRU_RS09290	COG1331	Highly conserved protein containing a thioredoxin domain
MURRU_RS09300	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
MURRU_RS09315	COG3275	phosphorelay sensor kinase activity
MURRU_RS09320	COG3279	Response regulator of the LytR AlgR family
MURRU_RS09325	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
MURRU_RS09330	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
MURRU_RS09380	COG2827	Endonuclease containing a URI domain
MURRU_RS09390	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
MURRU_RS09400	COG1428	Deoxynucleoside kinase
MURRU_RS09405	COG0616	signal peptide processing
MURRU_RS09440	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
MURRU_RS09450	COG0544	peptidyl-prolyl cis-trans isomerase activity
MURRU_RS09455	COG1950	PFAM Membrane protein of
MURRU_RS09465	COG0596	Alpha beta hydrolase
MURRU_RS09470	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
MURRU_RS09480	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
MURRU_RS09490	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MURRU_RS09510	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
MURRU_RS09515	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
MURRU_RS09560	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
MURRU_RS09565	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MURRU_RS09575	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
MURRU_RS09580	COG2086	electron transfer activity
MURRU_RS09585	COG0022	dehydrogenase e1 component
MURRU_RS09585	COG0508	dehydrogenase complex catalyzes the overall conversion of
MURRU_RS09595	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
MURRU_RS09600	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
MURRU_RS09615	COG1428	Deoxynucleoside kinase
MURRU_RS09620	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
MURRU_RS09635	COG0460	homoserine dehydrogenase
MURRU_RS09635	COG0527	aspartate kinase activity
MURRU_RS09645	COG1959	2 iron, 2 sulfur cluster binding
MURRU_RS09655	COG0175	sulfate reduction
MURRU_RS09660	COG0175	sulfate reduction
MURRU_RS09665	COG2895	sulfate adenylyltransferase (ATP) activity
MURRU_RS09670	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MURRU_RS09680	COG0492	ferredoxin-NADP+ reductase activity
MURRU_RS09690	COG1028	Short-chain dehydrogenase reductase Sdr
MURRU_RS09695	COG1410	methionine synthase
MURRU_RS09695	COG0646	methionine synthase
MURRU_RS09705	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
MURRU_RS09725	COG0076	glutamate decarboxylase activity
MURRU_RS09730	COG1131	(ABC) transporter
MURRU_RS09735	COG0077	Prephenate dehydratase
MURRU_RS09740	COG0436	Aminotransferase
MURRU_RS09745	COG0287	Prephenate dehydrogenase
MURRU_RS09750	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
MURRU_RS09770	COG1162	GTPase activity
MURRU_RS09775	COG1490	D-aminoacyl-tRNA deacylase activity
MURRU_RS09805	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
MURRU_RS09810	COG0820	rRNA (adenine-C2-)-methyltransferase activity
MURRU_RS09815	COG0142	geranyltranstransferase activity
MURRU_RS09820	COG1595	DNA-templated transcription, initiation
MURRU_RS09850	COG2936	dipeptidyl-peptidase activity
MURRU_RS09855	COG0358	DNA primase activity
MURRU_RS09860	COG2197	response regulator
MURRU_RS09865	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
MURRU_RS09885	COG1741	Belongs to the pirin family
MURRU_RS09890	COG0218	Necessary for normal cell division and for the maintenance of normal septation
MURRU_RS09900	COG2001	Belongs to the MraZ family
MURRU_RS09905	COG0275	rRNA processing
MURRU_RS09915	COG0768	penicillin binding
MURRU_RS09920	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
MURRU_RS09925	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MURRU_RS09930	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
MURRU_RS09940	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
MURRU_RS09945	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
MURRU_RS09960	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
MURRU_RS09965	COG1610	YqeY-like protein
MURRU_RS10030	COG0386	Belongs to the glutathione peroxidase family
MURRU_RS10040	COG0492	ferredoxin-NADP+ reductase activity
MURRU_RS10045	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
MURRU_RS10050	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MURRU_RS10055	COG1185	polyribonucleotide nucleotidyltransferase activity
MURRU_RS10060	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
MURRU_RS10065	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
MURRU_RS10070	COG0191	fructose-bisphosphate aldolase activity
MURRU_RS10080	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MURRU_RS10095	COG2226	methyltransferase
MURRU_RS10100	COG0569	domain protein
MURRU_RS10105	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MURRU_RS10115	COG3239	Fatty acid desaturase
MURRU_RS10120	COG0357	Ribosomal RNA small subunit methyltransferase G
MURRU_RS10135	COG1012	belongs to the aldehyde dehydrogenase family
MURRU_RS10140	COG2967	ApaG domain
MURRU_RS10155	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
MURRU_RS10160	COG1805	sodium ion transport
MURRU_RS10165	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
MURRU_RS10170	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
MURRU_RS10175	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
MURRU_RS10190	COG1477	protein flavinylation
MURRU_RS10195	COG2226	methyltransferase
MURRU_RS10205	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
MURRU_RS10215	COG0501	Belongs to the peptidase M48B family
MURRU_RS10255	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MURRU_RS10270	COG0456	acetyltransferase
MURRU_RS10275	COG3844	kynureninase activity
MURRU_RS10295	COG1595	DNA-templated transcription, initiation
MURRU_RS10310	COG0740	serine-type endopeptidase activity
MURRU_RS10315	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MURRU_RS10325	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
MURRU_RS10330	COG1663	tetraacyldisaccharide 4'-kinase activity
MURRU_RS10340	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MURRU_RS10345	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
MURRU_RS10365	COG1595	DNA-templated transcription, initiation
MURRU_RS10370	COG0812	UDP-N-acetylmuramate dehydrogenase activity
MURRU_RS10375	COG0436	Aminotransferase
MURRU_RS10380	COG0750	zinc metalloprotease
MURRU_RS10390	COG0525	valine-tRNA ligase activity
MURRU_RS10395	COG0673	inositol 2-dehydrogenase activity
MURRU_RS10400	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
MURRU_RS10420	COG0688	phosphatidylethanolamine metabolic process
MURRU_RS10425	COG4589	Belongs to the CDS family
MURRU_RS10435	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MURRU_RS10440	COG0799	negative regulation of ribosome biogenesis
MURRU_RS10455	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
MURRU_RS10470	COG2201	protein-glutamate methylesterase activity
MURRU_RS10480	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
MURRU_RS10485	COG1181	Belongs to the D-alanine--D-alanine ligase family
MURRU_RS10490	COG0515	serine threonine protein kinase
MURRU_RS10490	COG2815	serine threonine protein kinase
MURRU_RS10495	COG0564	pseudouridine synthase activity
MURRU_RS10500	COG3022	response to hydroperoxide
MURRU_RS10505	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
MURRU_RS10530	COG0159	tryptophan synthase activity
MURRU_RS10535	COG0133	tryptophan synthase activity
MURRU_RS10540	COG0135	phosphoribosylanthranilate isomerase activity
MURRU_RS10545	COG0134	indole-3-glycerol-phosphate synthase activity
MURRU_RS10550	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MURRU_RS10555	COG0512	Glutamine amidotransferase of anthranilate synthase
MURRU_RS10560	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MURRU_RS10570	COG2353	YceI-like domain
MURRU_RS10575	COG0778	Nitroreductase
MURRU_RS10580	COG1846	Transcriptional regulator
MURRU_RS10585	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MURRU_RS10615	COG1115	amino acid carrier protein
MURRU_RS10630	COG0828	Belongs to the bacterial ribosomal protein bS21 family
MURRU_RS10635	COG4974	Belongs to the 'phage' integrase family
MURRU_RS10640	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
MURRU_RS10685	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
MURRU_RS10690	COG0081	regulation of translation
MURRU_RS10695	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
MURRU_RS10700	COG0222	ribosome binding
MURRU_RS10705	COG0085	RNA polymerase activity
MURRU_RS10710	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MURRU_RS10725	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
MURRU_RS10760	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
MURRU_RS10770	COG1482	cell wall glycoprotein biosynthetic process
MURRU_RS10810	COG2258	MOSC domain
MURRU_RS10820	COG1595	DNA-templated transcription, initiation
MURRU_RS10840	COG0326	Molecular chaperone. Has ATPase activity
MURRU_RS10855	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MURRU_RS10875	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
MURRU_RS10880	COG0508	dehydrogenase complex catalyzes the overall conversion of
MURRU_RS10885	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
MURRU_RS10890	COG0179	Fumarylacetoacetate (FAA) hydrolase
MURRU_RS10900	COG1546	Belongs to the CinA family
MURRU_RS10900	COG1058	Belongs to the CinA family
MURRU_RS10905	COG0227	Belongs to the bacterial ribosomal protein bL28 family
MURRU_RS10910	COG0267	Belongs to the bacterial ribosomal protein bL33 family
MURRU_RS10915	COG0552	protein localization to endoplasmic reticulum
MURRU_RS10920	COG0154	amidase activity
MURRU_RS10925	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MURRU_RS10965	COG0714	Associated with various cellular activities
MURRU_RS10980	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MURRU_RS11005	COG1115	amino acid carrier protein
MURRU_RS11020	COG0668	transmembrane transport
MURRU_RS11025	COG0813	purine-nucleoside phosphorylase activity
MURRU_RS11030	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
MURRU_RS11040	COG5002	protein histidine kinase activity
MURRU_RS11050	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
MURRU_RS11055	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
MURRU_RS11075	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
MURRU_RS11085	COG0343	queuine tRNA-ribosyltransferase activity
MURRU_RS11095	COG0825	malonyl-CoA metabolic process
MURRU_RS11100	COG0305	Participates in initiation and elongation during chromosome replication
MURRU_RS11120	COG0561	phosphatase activity
MURRU_RS11130	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
MURRU_RS11135	COG0291	Belongs to the bacterial ribosomal protein bL35 family
MURRU_RS11140	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
MURRU_RS11145	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MURRU_RS11175	COG1272	protein, Hemolysin III
MURRU_RS11195	COG0116	Belongs to the methyltransferase superfamily
MURRU_RS11195	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
MURRU_RS11220	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MURRU_RS11225	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MURRU_RS11230	COG1366	Belongs to the anti-sigma-factor antagonist family
MURRU_RS11250	COG5479	isomerase activity
MURRU_RS11250	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
MURRU_RS11265	COG2851	Citrate transporter
MURRU_RS11275	COG0673	inositol 2-dehydrogenase activity
MURRU_RS11295	COG4771	TonB-dependent receptor
MURRU_RS11300	COG0702	epimerase
MURRU_RS11315	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MURRU_RS11320	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
MURRU_RS11350	COG1385	rRNA (uridine-N3-)-methyltransferase activity
MURRU_RS11355	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
MURRU_RS11365	COG0205	6-phosphofructokinase activity
MURRU_RS11380	COG0251	oxidation-reduction process
MURRU_RS11390	COG0860	N-Acetylmuramoyl-L-alanine amidase
MURRU_RS11400	COG2181	nitrate reductase activity
MURRU_RS11400	COG0247	lactate metabolic process
MURRU_RS11405	COG2181	nitrate reductase activity
MURRU_RS11405	COG0247	lactate metabolic process
MURRU_RS11420	COG0438	transferase activity, transferring glycosyl groups
MURRU_RS11430	COG2885	chlorophyll binding
MURRU_RS11435	COG1959	2 iron, 2 sulfur cluster binding
MURRU_RS11440	COG3291	Pkd domain containing protein
MURRU_RS11495	COG0438	transferase activity, transferring glycosyl groups
MURRU_RS11515	COG0438	transferase activity, transferring glycosyl groups
MURRU_RS11520	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
MURRU_RS11545	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
MURRU_RS11610	COG0492	ferredoxin-NADP+ reductase activity
MURRU_RS11630	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MURRU_RS11640	COG1619	proteins homologs of microcin C7 resistance protein MccF
MURRU_RS11655	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
MURRU_RS11660	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MURRU_RS11665	COG0519	Catalyzes the synthesis of GMP from XMP
MURRU_RS11665	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MURRU_RS11670	COG1388	LysM domain
MURRU_RS11670	COG0860	N-Acetylmuramoyl-L-alanine amidase
MURRU_RS11700	COG3530	Putative quorum-sensing-regulated virulence factor
MURRU_RS11705	COG0504	CTP synthase activity
MURRU_RS11710	COG0706	membrane insertase activity
MURRU_RS11720	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
MURRU_RS11725	COG0482	sulfurtransferase activity
MURRU_RS11745	COG0714	Associated with various cellular activities
MURRU_RS11775	COG2860	membrane
MURRU_RS11790	COG0412	Dienelactone hydrolase
MURRU_RS11820	COG1473	amidohydrolase
MURRU_RS11825	COG1252	NADH dehydrogenase
MURRU_RS11840	COG4974	Belongs to the 'phage' integrase family
MURRU_RS11860	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
MURRU_RS11870	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MURRU_RS11880	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MURRU_RS11885	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MURRU_RS11895	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
MURRU_RS11910	COG2270	Major facilitator Superfamily
MURRU_RS11940	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
MURRU_RS11945	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
MURRU_RS11955	COG4680	protein conserved in bacteria
MURRU_RS11970	COG1652	LysM domain
MURRU_RS11970	COG2823	Periplasmic or secreted lipoprotein
MURRU_RS11975	COG0539	negative regulation of cytoplasmic translation
MURRU_RS11980	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
MURRU_RS11985	COG0540	Belongs to the ATCase OTCase family
MURRU_RS11995	COG1234	tRNA 3'-trailer cleavage
MURRU_RS12000	COG0259	pyridoxamine-phosphate oxidase activity
MURRU_RS12010	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
MURRU_RS12055	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
MURRU_RS12085	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
MURRU_RS12095	COG1454	alcohol dehydrogenase
MURRU_RS12110	COG0217	transcriptional regulatory protein
MURRU_RS12115	COG2154	pterin-4-alpha-carbinolamine dehydratase
MURRU_RS12125	COG0404	The glycine cleavage system catalyzes the degradation of glycine
MURRU_RS12130	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
MURRU_RS12135	COG0083	homoserine kinase activity
MURRU_RS12140	COG0527	aspartate kinase activity
MURRU_RS12140	COG0460	homoserine dehydrogenase
MURRU_RS12145	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
MURRU_RS12155	COG0542	response to heat
MURRU_RS12170	COG0791	NLP P60 protein
MURRU_RS12175	COG0183	Belongs to the thiolase family
MURRU_RS12180	COG1480	7TM receptor with intracellular HD hydrolase
MURRU_RS12220	COG2217	Heavy metal translocating P-type atpase
MURRU_RS12225	COG1742	UPF0060 membrane protein
MURRU_RS12260	COG0629	single-stranded DNA binding
MURRU_RS12265	COG2003	Belongs to the UPF0758 family
MURRU_RS12295	COG0433	COG0433 Predicted ATPase
MURRU_RS12315	COG1396	sequence-specific DNA binding
MURRU_RS12330	COG1629	transport
MURRU_RS12335	COG0702	epimerase
MURRU_RS12360	COG2169	Transcriptional regulator
MURRU_RS12410	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
MURRU_RS12430	COG1595	DNA-templated transcription, initiation
MURRU_RS12445	COG1228	amidohydrolase
MURRU_RS12495	COG1063	alcohol dehydrogenase
MURRU_RS12540	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
MURRU_RS12555	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
MURRU_RS12570	COG0860	N-Acetylmuramoyl-L-alanine amidase
MURRU_RS12645	COG4974	Belongs to the 'phage' integrase family
MURRU_RS12670	COG1475	DNA binding
MURRU_RS12685	COG0587	DNA-directed DNA polymerase activity
MURRU_RS12695	COG0629	single-stranded DNA binding
MURRU_RS12700	COG2003	Belongs to the UPF0758 family
MURRU_RS12805	COG4771	TonB-dependent receptor
MURRU_RS12810	COG0702	epimerase
MURRU_RS12840	COG0156	8-amino-7-oxononanoate synthase activity
MURRU_RS12875	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MURRU_RS12880	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
MURRU_RS12885	COG0351	phosphomethylpyrimidine kinase
MURRU_RS12885	COG0352	thiamine-phosphate diphosphorylase activity
MURRU_RS12890	COG0352	thiamine-phosphate diphosphorylase activity
MURRU_RS12895	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
MURRU_RS12995	COG0583	DNA-binding transcription factor activity
MURRU_RS13000	COG0450	alkyl hydroperoxide reductase
MURRU_RS13005	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
MURRU_RS13010	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MURRU_RS13015	COG0626	cystathionine gamma-synthase activity
MURRU_RS13025	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
MURRU_RS13040	COG4771	TonB-dependent receptor
MURRU_RS13055	COG3189	MarR family transcriptional regulator
MURRU_RS13060	COG4221	oxidoreductase activity
MURRU_RS13065	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
MURRU_RS13075	COG1764	response to oxidative stress
MURRU_RS13080	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
MURRU_RS13090	COG3483	tryptophan 2,3-dioxygenase activity
MURRU_RS13100	COG2346	COG2346, Truncated hemoglobins
MURRU_RS13145	COG0302	gtp cyclohydrolase
MURRU_RS13175	COG1333	cytochrome c biogenesis protein
MURRU_RS13175	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MURRU_RS13180	COG0076	glutamate decarboxylase activity
MURRU_RS13225	COG1959	2 iron, 2 sulfur cluster binding
MURRU_RS13230	COG0038	chloride channel
MURRU_RS13235	COG0076	glutamate decarboxylase activity
MURRU_RS13240	COG1999	signal sequence binding
MURRU_RS13300	COG4771	TonB-dependent receptor
MURRU_RS13320	COG0179	Fumarylacetoacetate (FAA) hydrolase
MURRU_RS13325	COG1304	FMN binding
MURRU_RS13330	COG0574	Belongs to the PEP-utilizing enzyme family
MURRU_RS13330	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MURRU_RS13355	COG3550	peptidyl-serine autophosphorylation
MURRU_RS13365	COG1131	(ABC) transporter
MURRU_RS13370	COG3655	Transcriptional regulator
MURRU_RS13385	COG0778	Nitroreductase
MURRU_RS13395	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
MURRU_RS13400	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
MURRU_RS13470	COG4974	Belongs to the 'phage' integrase family
MURRU_RS13500	COG1028	Short-chain dehydrogenase reductase Sdr
MURRU_RS13525	COG1629	transport
MURRU_RS13525	COG4206	TonB-dependent receptor
MURRU_RS13540	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
MURRU_RS13550	COG1012	belongs to the aldehyde dehydrogenase family
MURRU_RS13555	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
MURRU_RS13565	COG4585	Histidine kinase
MURRU_RS13575	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MURRU_RS13575	COG2146	nitrite reductase [NAD(P)H] activity
MURRU_RS13580	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MURRU_RS13590	COG2223	nitrite transmembrane transporter activity
MURRU_RS13605	COG0243	molybdopterin cofactor binding
MURRU_RS13610	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MURRU_RS13610	COG1773	rubredoxin
MURRU_RS13625	COG4206	TonB-dependent receptor
MURRU_RS13625	COG1629	transport
MURRU_RS13675	COG1028	Short-chain dehydrogenase reductase Sdr
MURRU_RS13680	COG1312	Catalyzes the dehydration of D-mannonate
MURRU_RS13685	COG1904	glucuronate isomerase
MURRU_RS13695	COG0800	Aldolase
MURRU_RS13705	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
MURRU_RS13720	COG0673	inositol 2-dehydrogenase activity
MURRU_RS13725	COG0673	inositol 2-dehydrogenase activity
MURRU_RS13755	COG0659	secondary active sulfate transmembrane transporter activity
MURRU_RS13795	COG4251	negative regulation of phosphorylation
MURRU_RS13800	COG0784	Response regulator, receiver
MURRU_RS13810	COG2197	response regulator
MURRU_RS13815	COG0784	Response regulator, receiver
MURRU_RS13815	COG2198	Histidine kinase
MURRU_RS13815	COG5002	protein histidine kinase activity
MURRU_RS13820	COG4191	Histidine kinase
MURRU_RS13835	COG4771	TonB-dependent receptor
MURRU_RS13840	COG0702	epimerase
MURRU_RS13860	COG4771	TonB-dependent receptor
MURRU_RS13865	COG0702	epimerase
MURRU_RS13895	COG3119	arylsulfatase activity
MURRU_RS13915	COG0667	Aldo Keto reductase
MURRU_RS13940	COG1959	2 iron, 2 sulfur cluster binding
MURRU_RS13985	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
MURRU_RS13995	COG1959	2 iron, 2 sulfur cluster binding
MURRU_RS14000	COG0746	molybdenum cofactor guanylyltransferase activity
MURRU_RS14010	COG2272	Belongs to the type-B carboxylesterase lipase family
MURRU_RS14015	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MURRU_RS14025	COG0673	inositol 2-dehydrogenase activity
MURRU_RS14030	COG0823	Involved in the tonB-independent uptake of proteins
MURRU_RS14040	COG4181	ATPase activity
MURRU_RS14065	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MURRU_RS14075	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
MURRU_RS14080	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
MURRU_RS14085	COG0484	heat shock protein binding
MURRU_RS14095	COG0589	response to stress
MURRU_RS14105	COG5002	protein histidine kinase activity
MURRU_RS14110	COG0745	RESPONSE REGULATOR receiver
MURRU_RS14115	COG0589	response to stress
MURRU_RS14155	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MURRU_RS14160	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MURRU_RS14170	COG0312	modulator of DNA gyrase
MURRU_RS14180	COG0714	Associated with various cellular activities
MURRU_RS14205	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
MURRU_RS14210	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MURRU_RS14210	COG0574	Belongs to the PEP-utilizing enzyme family
MURRU_RS14240	COG0667	Aldo Keto reductase
MURRU_RS14245	COG2814	Major facilitator Superfamily
MURRU_RS14290	COG2249	NAD(P)H dehydrogenase (quinone) activity
MURRU_RS14295	COG1733	regulation of RNA biosynthetic process
MURRU_RS14300	COG1733	regulation of RNA biosynthetic process
MURRU_RS14305	COG2249	NAD(P)H dehydrogenase (quinone) activity
MURRU_RS14380	COG0745	RESPONSE REGULATOR receiver
MURRU_RS14390	COG1215	transferase activity, transferring glycosyl groups
MURRU_RS14395	COG5002	protein histidine kinase activity
MURRU_RS14410	COG0720	synthase
MURRU_RS14415	COG1959	2 iron, 2 sulfur cluster binding
MURRU_RS14420	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
MURRU_RS14425	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
MURRU_RS14460	COG4680	protein conserved in bacteria
MURRU_RS14465	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
MURRU_RS14475	COG0592	DNA-directed DNA polymerase activity
MURRU_RS14485	COG0842	Transport permease protein
MURRU_RS14500	COG1702	phosphate starvation-inducible protein PhoH
MURRU_RS14505	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
MURRU_RS14515	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MURRU_RS14520	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MURRU_RS14565	COG1678	Uncharacterized ACR, COG1678
MURRU_RS14575	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
MURRU_RS14580	COG0514	ATP-dependent DNA helicase (RecQ)
MURRU_RS14600	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
MURRU_RS14615	COG0640	Transcriptional regulator
MURRU_RS14625	COG1473	amidohydrolase
MURRU_RS14630	COG0415	Belongs to the DNA photolyase family
MURRU_RS14665	COG0424	maF-like protein
MURRU_RS14680	COG1333	cytochrome c biogenesis protein
MURRU_RS14680	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MURRU_RS14690	COG0534	Mate efflux family protein
MURRU_RS14695	COG0626	cystathionine gamma-synthase activity
MURRU_RS14700	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
MURRU_RS14705	COG2202	Pas domain
MURRU_RS14705	COG2205	protein histidine kinase activity
MURRU_RS14715	COG2234	aminopeptidase activity
MURRU_RS14720	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MURRU_RS14735	COG2050	protein possibly involved in aromatic compounds catabolism
MURRU_RS14745	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
MURRU_RS14765	COG1575	Belongs to the MenA family. Type 1 subfamily
MURRU_RS14770	COG0784	Response regulator, receiver
MURRU_RS14780	COG4948	Mandelate Racemase Muconate Lactonizing
MURRU_RS14785	COG1266	CAAX protease self-immunity
MURRU_RS14800	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
MURRU_RS14815	COG0488	(ABC) transporter
MURRU_RS14855	COG1393	Belongs to the ArsC family
MURRU_RS14860	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
MURRU_RS14875	COG2827	Endonuclease containing a URI domain
MURRU_RS14880	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
MURRU_RS14895	COG0156	8-amino-7-oxononanoate synthase activity
MURRU_RS14920	COG2801	Transposase and inactivated derivatives
MURRU_RS14920	COG3415	Transposase
MURRU_RS14925	COG2963	transposase activity
MURRU_RS14945	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MURRU_RS14950	COG4974	Belongs to the 'phage' integrase family
MURRU_RS14960	COG2207	Transcriptional regulator
MURRU_RS15000	COG2885	chlorophyll binding
MURRU_RS15030	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
MURRU_RS15035	COG1595	DNA-templated transcription, initiation
MURRU_RS15040	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MURRU_RS15045	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
MURRU_RS15075	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
MURRU_RS15085	COG1216	Glycosyl transferase, family 2
MURRU_RS15085	COG0463	Glycosyl transferase, family 2
MURRU_RS15110	COG0673	inositol 2-dehydrogenase activity
MURRU_RS15115	COG2318	DinB family
MURRU_RS15135	COG1132	(ABC) transporter
MURRU_RS15140	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MURRU_RS15150	COG1862	Preprotein translocase
MURRU_RS15165	COG1136	(ABC) transporter
MURRU_RS15170	COG0450	alkyl hydroperoxide reductase
MURRU_RS15175	COG1278	Cold shock
MURRU_RS15185	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
MURRU_RS15190	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MURRU_RS15195	COG0302	gtp cyclohydrolase
MURRU_RS15205	COG4771	TonB-dependent receptor
MURRU_RS15230	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MURRU_RS15235	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
MURRU_RS15245	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
MURRU_RS15250	COG0012	GTP binding
MURRU_RS15290	COG1522	sequence-specific DNA binding
MURRU_RS15305	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
MURRU_RS15380	COG1078	dGTPase activity
MURRU_RS15385	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MURRU_RS15390	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
MURRU_RS15390	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
MURRU_RS15395	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MURRU_RS15400	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
MURRU_RS15405	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MURRU_RS15410	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
MURRU_RS15415	COG1028	Short-chain dehydrogenase reductase Sdr
MURRU_RS15430	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
MURRU_RS15435	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
MURRU_RS15440	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MURRU_RS15445	COG0131	Imidazoleglycerol-phosphate dehydratase
MURRU_RS15460	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
MURRU_RS15470	COG0107	imidazoleglycerol-phosphate synthase activity
MURRU_RS15475	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
MURRU_RS15475	COG0140	phosphoribosyl-ATP diphosphatase activity
MURRU_RS15500	COG1045	serine acetyltransferase
MURRU_RS15530	COG1607	acyl-coa hydrolase
MURRU_RS15550	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MURRU_RS15565	COG1193	negative regulation of DNA recombination
MURRU_RS15570	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
MURRU_RS15600	COG0022	dehydrogenase e1 component
MURRU_RS15620	COG0697	spore germination
MURRU_RS15655	COG3386	PFAM SMP-30 Gluconolaconase
MURRU_RS15665	COG0405	Gamma-glutamyltransferase
MURRU_RS15675	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MURRU_RS15690	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MURRU_RS15700	COG0247	lactate metabolic process
MURRU_RS15700	COG0277	FAD linked oxidase domain protein
MURRU_RS15705	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MURRU_RS15710	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
MURRU_RS15715	COG1301	dicarboxylic acid transport
MURRU_RS15720	COG4771	TonB-dependent receptor
MURRU_RS15725	COG3011	Protein conserved in bacteria
MURRU_RS15730	COG2388	GCN5-related N-acetyl-transferase
MURRU_RS15780	COG1012	belongs to the aldehyde dehydrogenase family
MURRU_RS15810	COG1047	Peptidyl-prolyl cis-trans
MURRU_RS15845	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
MURRU_RS15855	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
MURRU_RS15870	COG0640	Transcriptional regulator
MURRU_RS15880	COG2003	Belongs to the UPF0758 family
MURRU_RS15890	COG5002	protein histidine kinase activity
MURRU_RS15930	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
MURRU_RS15935	COG1611	Belongs to the LOG family
MURRU_RS15975	COG0009	L-threonylcarbamoyladenylate synthase
MURRU_RS15985	COG1073	alpha beta
MURRU_RS16005	COG1473	amidohydrolase
MURRU_RS16015	COG0069	glutamate synthase activity
MURRU_RS16040	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
MURRU_RS16045	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
MURRU_RS16050	COG0066	3-isopropylmalate dehydratase activity
MURRU_RS16060	COG0473	3-isopropylmalate dehydrogenase activity
MURRU_RS16065	COG1012	belongs to the aldehyde dehydrogenase family
MURRU_RS16070	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
MURRU_RS16075	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
MURRU_RS16080	COG0440	acetolactate synthase activity
MURRU_RS16085	COG0028	Belongs to the TPP enzyme family
MURRU_RS16090	COG0129	dihydroxy-acid dehydratase activity
MURRU_RS16100	COG1984	allophanate hydrolase subunit 2
MURRU_RS16105	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
MURRU_RS16115	COG1914	H( )-stimulated, divalent metal cation uptake system
MURRU_RS16130	COG0606	chelatase, subunit chli
MURRU_RS16145	COG0037	tRNA processing
MURRU_RS16160	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MURRU_RS16175	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MURRU_RS16190	COG1522	sequence-specific DNA binding
MURRU_RS16195	COG0626	cystathionine gamma-synthase activity
MURRU_RS16200	COG1757	Na H antiporter
MURRU_RS16205	COG0450	alkyl hydroperoxide reductase
MURRU_RS16210	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MURRU_RS16225	COG1674	ftsk spoiiie
MURRU_RS16240	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MURRU_RS16240	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MURRU_RS16265	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MURRU_RS16270	COG1120	ATPase activity
MURRU_RS16285	COG2852	Protein conserved in bacteria
MURRU_RS16295	COG0363	glucosamine-6-phosphate deaminase activity
MURRU_RS16300	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
MURRU_RS16305	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
MURRU_RS16315	COG4946	Tricorn protease homolog
MURRU_RS16315	COG0823	Involved in the tonB-independent uptake of proteins
MURRU_RS16315	COG1506	peptidase
MURRU_RS16355	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
MURRU_RS16410	COG1741	Belongs to the pirin family
MURRU_RS16420	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
MURRU_RS16425	COG0730	response to heat
MURRU_RS16435	COG4974	Belongs to the 'phage' integrase family
MURRU_RS16440	COG4974	Belongs to the 'phage' integrase family
MURRU_RS16445	COG3550	peptidyl-serine autophosphorylation
MURRU_RS16465	COG0471	metal ion transport
MURRU_RS16475	COG1940	carbohydrate kinase activity
MURRU_RS16480	COG0738	Major facilitator superfamily
MURRU_RS16490	COG0702	epimerase
MURRU_RS16495	COG4771	TonB-dependent receptor
MURRU_RS16505	COG1595	DNA-templated transcription, initiation
MURRU_RS16565	COG0673	inositol 2-dehydrogenase activity
MURRU_RS16575	COG2814	Major facilitator Superfamily
MURRU_RS16590	COG0702	epimerase
MURRU_RS16595	COG1629	transport
MURRU_RS16600	COG4193	domain, Protein
MURRU_RS16615	COG2197	response regulator
MURRU_RS16620	COG4585	Histidine kinase
MURRU_RS16635	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
MURRU_RS16640	COG1538	Outer membrane efflux protein
MURRU_RS16650	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MURRU_RS16670	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
MURRU_RS16685	COG1629	transport
MURRU_RS16720	COG0730	response to heat
MURRU_RS16725	COG0303	'Molybdopterin
MURRU_RS16735	COG0521	Mo-molybdopterin cofactor biosynthetic process
MURRU_RS16735	COG0315	cyclic pyranopterin monophosphate synthase activity
MURRU_RS16740	COG0314	molybdopterin synthase activity
MURRU_RS16745	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
MURRU_RS16755	COG2068	MobA-Related Protein
MURRU_RS16760	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
MURRU_RS16765	COG1104	cysteine desulfurase activity
MURRU_RS16785	COG0798	PFAM Bile acid sodium symporter
MURRU_RS16800	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MURRU_RS16815	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MURRU_RS16825	COG0659	secondary active sulfate transmembrane transporter activity
MURRU_RS16845	COG0443	Heat shock 70 kDa protein
MURRU_RS16850	COG1760	l-serine dehydratase
MURRU_RS16860	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
MURRU_RS16865	COG0564	pseudouridine synthase activity
MURRU_RS16875	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MURRU_RS16880	COG0473	3-isopropylmalate dehydrogenase activity
MURRU_RS16905	COG0488	(ABC) transporter
MURRU_RS16915	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
MURRU_RS16920	COG0300	oxidoreductase activity
MURRU_RS16960	COG4585	Histidine kinase
MURRU_RS16975	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
MURRU_RS16985	COG3118	belongs to the thioredoxin family
MURRU_RS16990	COG0542	response to heat
MURRU_RS16995	COG2610	gluconate transmembrane transporter activity
MURRU_RS17035	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
MURRU_RS17040	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
MURRU_RS17045	COG0673	inositol 2-dehydrogenase activity
MURRU_RS17050	COG1250	3-hydroxyacyl-CoA dehydrogenase
MURRU_RS17060	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
MURRU_RS17070	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MURRU_RS17075	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
MURRU_RS17080	COG3265	gluconokinase activity
MURRU_RS17105	COG1216	Glycosyl transferase, family 2
MURRU_RS17105	COG0463	Glycosyl transferase, family 2
MURRU_RS17110	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
MURRU_RS17115	COG0497	DNA recombination
MURRU_RS17140	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MURRU_RS17155	COG0737	Belongs to the 5'-nucleotidase family
MURRU_RS17175	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
MURRU_RS17180	COG2890	protein-(glutamine-N5) methyltransferase activity
MURRU_RS17190	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MURRU_RS17190	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MURRU_RS17195	COG1011	Hydrolase
MURRU_RS17200	COG0697	spore germination
MURRU_RS17205	COG1739	Uncharacterized protein family UPF0029
MURRU_RS17210	COG0824	Thioesterase
MURRU_RS17270	COG1366	Belongs to the anti-sigma-factor antagonist family
MURRU_RS17270	COG2202	Pas domain
MURRU_RS17345	COG3292	Two component regulator propeller
MURRU_RS17345	COG2205	protein histidine kinase activity
MURRU_RS17345	COG0745	RESPONSE REGULATOR receiver
MURRU_RS17370	COG2133	pyrroloquinoline quinone binding
MURRU_RS17370	COG5183	chlorophyll binding
MURRU_RS17385	COG5002	protein histidine kinase activity
MURRU_RS17450	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate