locus-tag	class	description
RBRH_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
RBRH_RS00030	COG0464	growth
RBRH_RS00060	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
RBRH_RS00060	COG4797	methyltransferase
RBRH_RS00155	COG1538	Outer membrane efflux protein
RBRH_RS00165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RBRH_RS00185	COG5265	(ABC) transporter
RBRH_RS00215	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RBRH_RS00215	COG2205	protein histidine kinase activity
RBRH_RS00235	COG2271	Major facilitator Superfamily
RBRH_RS00240	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
RBRH_RS00245	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
RBRH_RS00250	COG0277	FAD linked oxidase domain protein
RBRH_RS00265	COG1454	alcohol dehydrogenase
RBRH_RS00270	COG0583	DNA-binding transcription factor activity
RBRH_RS00300	COG2918	glutathione biosynthetic process
RBRH_RS00305	COG2169	Transcriptional regulator
RBRH_RS00305	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
RBRH_RS00310	COG0534	Mate efflux family protein
RBRH_RS00405	COG0523	cobalamin synthesis protein
RBRH_RS00485	COG0445	tRNA wobble uridine modification
RBRH_RS00495	COG1192	Involved in chromosome partitioning
RBRH_RS00500	COG1475	DNA binding
RBRH_RS00505	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
RBRH_RS00515	COG0356	it plays a direct role in the translocation of protons across the membrane
RBRH_RS00525	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
RBRH_RS00530	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
RBRH_RS00540	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
RBRH_RS00550	COG0355	proton-transporting ATP synthase activity, rotational mechanism
RBRH_RS00555	COG0318	PFAM AMP-dependent synthetase and ligase
RBRH_RS00565	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
RBRH_RS00580	COG0506	proline dehydrogenase activity
RBRH_RS00580	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
RBRH_RS00580	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
RBRH_RS00590	COG1760	l-serine dehydratase
RBRH_RS00605	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
RBRH_RS00605	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
RBRH_RS00610	COG0509	glycine decarboxylation via glycine cleavage system
RBRH_RS00615	COG0404	The glycine cleavage system catalyzes the degradation of glycine
RBRH_RS00620	COG0210	DNA helicase
RBRH_RS00625	COG3245	cytochrome
RBRH_RS00640	COG4453	Protein conserved in bacteria
RBRH_RS00655	COG0582	viral genome integration into host DNA
RBRH_RS00860	COG2155	Conserved Protein
RBRH_RS00870	COG2070	2-Nitropropane dioxygenase
RBRH_RS00880	COG3038	cytochrome b561
RBRH_RS00895	COG1012	belongs to the aldehyde dehydrogenase family
RBRH_RS00900	COG3384	dioxygenase
RBRH_RS00910	COG3971	2-oxopent-4-enoate hydratase activity
RBRH_RS00930	COG0561	phosphatase activity
RBRH_RS00935	COG0438	transferase activity, transferring glycosyl groups
RBRH_RS00945	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RBRH_RS00950	COG2746	aminoglycoside 3-N-acetyltransferase activity
RBRH_RS00955	COG3568	Endonuclease Exonuclease Phosphatase
RBRH_RS00980	COG1028	Short-chain dehydrogenase reductase Sdr
RBRH_RS00990	COG0037	tRNA processing
RBRH_RS00995	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
RBRH_RS01000	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
RBRH_RS01030	COG0300	oxidoreductase activity
RBRH_RS01040	COG0859	PFAM glycosyl transferase family 9
RBRH_RS01045	COG2192	nodulation
RBRH_RS01080	COG0297	glycogen (starch) synthase activity
RBRH_RS01105	COG3121	Chaperone
RBRH_RS01110	COG3188	usher protein
RBRH_RS01120	COG1280	lysine exporter protein (LysE YggA)
RBRH_RS01125	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
RBRH_RS01130	COG1881	PFAM PEBP family protein
RBRH_RS01135	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
RBRH_RS01140	COG0281	malic enzyme
RBRH_RS01140	COG0280	phosphate acetyltransferase
RBRH_RS01165	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
RBRH_RS01170	COG2151	metal-sulfur cluster biosynthetic enzyme
RBRH_RS01175	COG3396	Phenylacetate-CoA oxygenase
RBRH_RS01180	COG3460	Phenylacetate-CoA oxygenase
RBRH_RS01185	COG3396	Phenylacetate-CoA oxygenase
RBRH_RS01215	COG1473	amidohydrolase
RBRH_RS01230	COG0318	PFAM AMP-dependent synthetase and ligase
RBRH_RS01235	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
RBRH_RS01240	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
RBRH_RS01250	COG0275	rRNA processing
RBRH_RS01255	COG3116	cell division
RBRH_RS01265	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
RBRH_RS01270	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
RBRH_RS01280	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
RBRH_RS01290	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
RBRH_RS01295	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
RBRH_RS01300	COG1181	Belongs to the D-alanine--D-alanine ligase family
RBRH_RS01305	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
RBRH_RS01315	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
RBRH_RS01325	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
RBRH_RS01350	COG0494	nUDIX hydrolase
RBRH_RS01355	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
RBRH_RS01360	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
RBRH_RS01375	COG1459	type II secretion system
RBRH_RS01385	COG4536	flavin adenine dinucleotide binding
RBRH_RS01400	COG0142	geranyltranstransferase activity
RBRH_RS01410	COG0211	Belongs to the bacterial ribosomal protein bL27 family
RBRH_RS01415	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
RBRH_RS01420	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
RBRH_RS01435	COG0442	prolyl-tRNA aminoacylation
RBRH_RS01440	COG2095	MarC family integral membrane protein
RBRH_RS01450	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
RBRH_RS01455	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
RBRH_RS01470	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
RBRH_RS01470	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
RBRH_RS01500	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
RBRH_RS01505	COG2264	protein methyltransferase activity
RBRH_RS01510	COG0439	Biotin carboxylase
RBRH_RS01515	COG0511	ligase activity, forming carbon-carbon bonds
RBRH_RS01520	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
RBRH_RS01525	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
RBRH_RS01535	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
RBRH_RS01540	COG3150	esterase
RBRH_RS01545	COG0557	exoribonuclease II activity
RBRH_RS01550	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
RBRH_RS01555	COG0284	orotidine-5'-phosphate decarboxylase activity
RBRH_RS01560	COG1546	Belongs to the CinA family
RBRH_RS01565	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
RBRH_RS01590	COG1385	rRNA (uridine-N3-)-methyltransferase activity
RBRH_RS01595	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
RBRH_RS01600	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
RBRH_RS01610	COG0735	belongs to the Fur family
RBRH_RS01615	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
RBRH_RS01645	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
RBRH_RS01650	COG1981	membrane
RBRH_RS01685	COG3265	gluconokinase activity
RBRH_RS01700	COG0482	sulfurtransferase activity
RBRH_RS01715	COG1862	Preprotein translocase
RBRH_RS01720	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
RBRH_RS01725	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
RBRH_RS01740	COG2995	paraquat-inducible protein a
RBRH_RS01745	COG2995	paraquat-inducible protein a
RBRH_RS01750	COG3008	intermembrane lipid transfer
RBRH_RS01760	COG0343	queuine tRNA-ribosyltransferase activity
RBRH_RS01765	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
RBRH_RS01770	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
RBRH_RS01775	COG0583	DNA-binding transcription factor activity
RBRH_RS01795	COG0247	lactate metabolic process
RBRH_RS01800	COG0277	FAD linked oxidase domain protein
RBRH_RS01805	COG0277	FAD linked oxidase domain protein
RBRH_RS01810	COG0277	FAD linked oxidase domain protein
RBRH_RS01815	COG2096	Adenosyltransferase
RBRH_RS01820	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
RBRH_RS01825	COG0312	modulator of DNA gyrase
RBRH_RS01830	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
RBRH_RS01840	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
RBRH_RS01845	COG0497	DNA recombination
RBRH_RS01850	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
RBRH_RS01855	COG1420	regulation of RNA biosynthetic process
RBRH_RS01860	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
RBRH_RS01880	COG0443	Heat shock 70 kDa protein
RBRH_RS01900	COG1428	Deoxynucleoside kinase
RBRH_RS01910	COG0617	tRNA 3'-terminal CCA addition
RBRH_RS01920	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
RBRH_RS01925	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
RBRH_RS01935	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
RBRH_RS01940	COG0586	Pfam SNARE associated Golgi protein
RBRH_RS01945	COG0860	N-Acetylmuramoyl-L-alanine amidase
RBRH_RS01950	COG0802	atpase or kinase
RBRH_RS01955	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
RBRH_RS01965	COG4974	Belongs to the 'phage' integrase family
RBRH_RS01995	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
RBRH_RS02000	COG1666	GTP binding
RBRH_RS02005	COG0812	UDP-N-acetylmuramate dehydrogenase activity
RBRH_RS02010	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
RBRH_RS02020	COG0268	Binds directly to 16S ribosomal RNA
RBRH_RS02025	COG0728	peptidoglycan biosynthetic process
RBRH_RS02155	COG0563	adenylate kinase activity
RBRH_RS02160	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
RBRH_RS02175	COG1570	exodeoxyribonuclease VII activity
RBRH_RS02185	COG2814	Major facilitator Superfamily
RBRH_RS02220	COG4771	TonB-dependent receptor
RBRH_RS02225	COG1278	Cold shock
RBRH_RS02230	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
RBRH_RS02235	COG0542	response to heat
RBRH_RS02240	COG0756	dUTP diphosphatase activity
RBRH_RS02250	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
RBRH_RS02255	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
RBRH_RS02260	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
RBRH_RS02265	COG0196	riboflavin kinase activity
RBRH_RS02270	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
RBRH_RS02275	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
RBRH_RS02275	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
RBRH_RS02280	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
RBRH_RS02280	COG3264	Mechanosensitive ion channel
RBRH_RS02290	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
RBRH_RS02300	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
RBRH_RS02320	COG1047	Peptidyl-prolyl cis-trans
RBRH_RS02325	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
RBRH_RS02355	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
RBRH_RS02385	COG1253	flavin adenine dinucleotide binding
RBRH_RS02395	COG0583	DNA-binding transcription factor activity
RBRH_RS02410	COG0175	sulfate reduction
RBRH_RS02420	COG2895	sulfate adenylyltransferase (ATP) activity
RBRH_RS02425	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
RBRH_RS02425	COG1648	precorrin-2 dehydrogenase activity
RBRH_RS02445	COG0795	lipopolysaccharide-transporting ATPase activity
RBRH_RS02450	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
RBRH_RS02465	COG0583	DNA-binding transcription factor activity
RBRH_RS02470	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
RBRH_RS02495	COG4206	TonB-dependent receptor
RBRH_RS02505	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
RBRH_RS02525	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
RBRH_RS02530	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
RBRH_RS02565	COG2885	chlorophyll binding
RBRH_RS02565	COG3047	cAMP biosynthetic process
RBRH_RS02585	COG0717	Belongs to the dCTP deaminase family
RBRH_RS02620	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
RBRH_RS02630	COG2827	Endonuclease containing a URI domain
RBRH_RS02650	COG1193	negative regulation of DNA recombination
RBRH_RS02655	COG0492	ferredoxin-NADP+ reductase activity
RBRH_RS02660	COG1674	ftsk spoiiie
RBRH_RS02665	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
RBRH_RS02670	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
RBRH_RS02675	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
RBRH_RS02690	COG0850	regulation of cytokinetic process
RBRH_RS02700	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
RBRH_RS02730	COG0635	Involved in the biosynthesis of porphyrin-containing compound
RBRH_RS02735	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
RBRH_RS02740	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
RBRH_RS02750	COG0194	GDP metabolic process
RBRH_RS02755	COG1758	RNA polymerase activity
RBRH_RS02760	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
RBRH_RS02775	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
RBRH_RS02785	COG1278	Cold shock
RBRH_RS02810	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
RBRH_RS02815	COG0308	aminopeptidase N
RBRH_RS02825	COG2119	membrane
RBRH_RS02830	COG0402	S-adenosylhomocysteine deaminase activity
RBRH_RS02835	COG2252	PERMEase
RBRH_RS02840	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
RBRH_RS02845	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
RBRH_RS02855	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
RBRH_RS02875	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
RBRH_RS02885	COG3383	formate dehydrogenase (NAD+) activity
RBRH_RS02900	COG1910	domain protein
RBRH_RS02925	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
RBRH_RS02945	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
RBRH_RS02955	COG0287	Prephenate dehydrogenase
RBRH_RS02960	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
RBRH_RS02975	COG0776	regulation of translation
RBRH_RS02985	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
RBRH_RS02995	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
RBRH_RS03000	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RBRH_RS03015	COG2951	lytic endotransglycosylase activity
RBRH_RS03030	COG2011	ABC-type metal ion transport system permease component
RBRH_RS03080	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
RBRH_RS03085	COG0336	Belongs to the RNA methyltransferase TrmD family
RBRH_RS03090	COG0335	large ribosomal subunit rRNA binding
RBRH_RS03095	COG0494	nUDIX hydrolase
RBRH_RS03110	COG1162	GTPase activity
RBRH_RS03115	COG0501	Belongs to the peptidase M48B family
RBRH_RS03125	COG0521	Mo-molybdopterin cofactor biosynthetic process
RBRH_RS03130	COG3028	Belongs to the UPF0307 family
RBRH_RS03135	COG0312	modulator of DNA gyrase
RBRH_RS03145	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
RBRH_RS03150	COG0114	fumarate hydratase activity
RBRH_RS03155	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RBRH_RS03160	COG0534	Mate efflux family protein
RBRH_RS03175	COG3045	CreA protein
RBRH_RS03210	COG1139	Iron-sulfur cluster binding protein
RBRH_RS03235	COG0303	'Molybdopterin
RBRH_RS03245	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
RBRH_RS03250	COG1530	ribonuclease E activity
RBRH_RS03285	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
RBRH_RS03330	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
RBRH_RS03355	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RBRH_RS03375	COG0571	ribonuclease III activity
RBRH_RS03380	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
RBRH_RS03390	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
RBRH_RS03395	COG0736	holo-[acyl-carrier-protein] synthase activity
RBRH_RS03410	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
RBRH_RS03420	COG0322	excinuclease ABC activity
RBRH_RS03445	COG2153	protein acetylation
RBRH_RS03455	COG1999	signal sequence binding
RBRH_RS03465	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
RBRH_RS03475	COG0438	transferase activity, transferring glycosyl groups
RBRH_RS03550	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
RBRH_RS03555	COG0328	RNA-DNA hybrid ribonuclease activity
RBRH_RS03560	COG2226	methyltransferase
RBRH_RS03565	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RBRH_RS03570	COG0741	lytic transglycosylase activity
RBRH_RS03570	COG1388	LysM domain
RBRH_RS03575	COG0583	DNA-binding transcription factor activity
RBRH_RS03585	COG0505	Belongs to the CarA family
RBRH_RS03595	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
RBRH_RS03605	COG1534	Rna-binding protein
RBRH_RS03615	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
RBRH_RS03630	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
RBRH_RS03635	COG0573	inorganic phosphate transmembrane transporter activity
RBRH_RS03640	COG0581	inorganic phosphate transmembrane transporter activity
RBRH_RS03645	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
RBRH_RS03655	COG0745	RESPONSE REGULATOR receiver
RBRH_RS03675	COG1522	sequence-specific DNA binding
RBRH_RS03680	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
RBRH_RS03685	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
RBRH_RS03695	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
RBRH_RS03700	COG0259	pyridoxamine-phosphate oxidase activity
RBRH_RS03705	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
RBRH_RS03715	COG1741	Belongs to the pirin family
RBRH_RS03730	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
RBRH_RS03750	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
RBRH_RS03775	COG0425	Belongs to the sulfur carrier protein TusA family
RBRH_RS03780	COG1210	Utp--glucose-1-phosphate uridylyltransferase
RBRH_RS03785	COG0525	valine-tRNA ligase activity
RBRH_RS03790	COG0210	DNA helicase
RBRH_RS03800	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
RBRH_RS03810	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
RBRH_RS03900	COG3077	Addiction module antitoxin, RelB DinJ family
RBRH_RS04030	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
RBRH_RS04100	COG3093	addiction module antidote protein HigA
RBRH_RS04120	COG1611	Belongs to the LOG family
RBRH_RS04130	COG1252	NADH dehydrogenase
RBRH_RS04150	COG1722	exodeoxyribonuclease VII activity
RBRH_RS04155	COG0142	geranyltranstransferase activity
RBRH_RS04160	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
RBRH_RS04165	COG1469	GTP cyclohydrolase I activity
RBRH_RS04170	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
RBRH_RS04175	COG2081	HI0933 family
RBRH_RS04315	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
RBRH_RS04330	COG0081	regulation of translation
RBRH_RS04335	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
RBRH_RS04340	COG0222	ribosome binding
RBRH_RS04350	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
RBRH_RS04365	COG0514	ATP-dependent DNA helicase (RecQ)
RBRH_RS04370	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
RBRH_RS04390	COG0051	transcription antitermination factor activity, RNA binding
RBRH_RS04400	COG0088	Forms part of the polypeptide exit tunnel
RBRH_RS04405	COG0089	rRNA binding
RBRH_RS04410	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
RBRH_RS04425	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
RBRH_RS04435	COG0255	Belongs to the universal ribosomal protein uL29 family
RBRH_RS04440	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
RBRH_RS04450	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
RBRH_RS04465	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
RBRH_RS04475	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
RBRH_RS04495	COG0201	protein transport
RBRH_RS04510	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
RBRH_RS04515	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
RBRH_RS04520	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
RBRH_RS04525	COG0202	RNA polymerase activity
RBRH_RS04530	COG0203	ribosomal protein L17
RBRH_RS04535	COG1324	tolerance protein
RBRH_RS04540	COG4232	protein-disulfide reductase activity
RBRH_RS04550	COG0218	Necessary for normal cell division and for the maintenance of normal septation
RBRH_RS04560	COG1333	cytochrome c biogenesis protein
RBRH_RS04565	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
RBRH_RS04580	COG1965	Belongs to the frataxin family
RBRH_RS04620	COG0232	Belongs to the dGTPase family. Type 2 subfamily
RBRH_RS04625	COG0584	glycerophosphoryl diester phosphodiesterase
RBRH_RS04655	COG0070	glutamate synthase
RBRH_RS04655	COG0069	glutamate synthase activity
RBRH_RS04655	COG0067	glutamate synthase
RBRH_RS04670	COG4178	(ABC) transporter
RBRH_RS04700	COG1127	ABC transporter
RBRH_RS04705	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
RBRH_RS04710	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
RBRH_RS04715	COG2853	Lipoprotein
RBRH_RS04730	COG1131	(ABC) transporter
RBRH_RS04735	COG0842	Transport permease protein
RBRH_RS04745	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
RBRH_RS04750	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
RBRH_RS04755	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
RBRH_RS04760	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
RBRH_RS04765	COG0131	Imidazoleglycerol-phosphate dehydratase
RBRH_RS04775	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
RBRH_RS04790	COG0140	phosphoribosyl-ATP diphosphatase activity
RBRH_RS04800	COG0537	adenosine 5'-monophosphoramidase activity
RBRH_RS04805	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
RBRH_RS04815	COG0805	protein transport
RBRH_RS04820	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RBRH_RS04825	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
RBRH_RS04835	COG0723	plastoquinol--plastocyanin reductase activity
RBRH_RS04840	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
RBRH_RS04845	COG2857	Cytochrome c1
RBRH_RS04850	COG0625	glutathione transferase activity
RBRH_RS04855	COG2969	positive regulation of protein catabolic process
RBRH_RS04885	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
RBRH_RS04930	COG0443	Heat shock 70 kDa protein
RBRH_RS04935	COG1278	Cold shock
RBRH_RS04940	COG0531	amino acid
RBRH_RS04955	COG3384	dioxygenase
RBRH_RS04965	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
RBRH_RS04970	COG2890	protein-(glutamine-N5) methyltransferase activity
RBRH_RS04975	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
RBRH_RS04980	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
RBRH_RS04990	COG0006	proline dipeptidase activity
RBRH_RS05000	COG0488	(ABC) transporter
RBRH_RS05005	COG5265	(ABC) transporter
RBRH_RS05010	COG0012	GTP binding
RBRH_RS05020	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RBRH_RS05040	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
RBRH_RS05055	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
RBRH_RS05060	COG0512	Glutamine amidotransferase of anthranilate synthase
RBRH_RS05070	COG0546	phosphoglycolate phosphatase activity
RBRH_RS05080	COG2967	ApaG domain
RBRH_RS05085	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
RBRH_RS05095	COG2050	protein possibly involved in aromatic compounds catabolism
RBRH_RS05100	COG1024	Enoyl-CoA hydratase
RBRH_RS05115	COG1024	Enoyl-CoA hydratase
RBRH_RS05190	COG1566	PFAM secretion protein HlyD family protein
RBRH_RS05210	COG0583	DNA-binding transcription factor activity
RBRH_RS05215	COG0277	FAD linked oxidase domain protein
RBRH_RS05230	COG1295	ribonuclease BN
RBRH_RS05250	COG1028	Short-chain dehydrogenase reductase Sdr
RBRH_RS05275	COG0251	oxidation-reduction process
RBRH_RS05280	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
RBRH_RS05300	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
RBRH_RS05305	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
RBRH_RS05310	COG0291	Belongs to the bacterial ribosomal protein bL35 family
RBRH_RS05330	COG0776	regulation of translation
RBRH_RS05340	COG1418	mRNA catabolic process
RBRH_RS05360	COG2205	protein histidine kinase activity
RBRH_RS05385	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
RBRH_RS05395	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
RBRH_RS05420	COG5002	protein histidine kinase activity
RBRH_RS05425	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
RBRH_RS05435	COG5642	Protein of unknown function (DUF2384)
RBRH_RS05440	COG1028	Short-chain dehydrogenase reductase Sdr
RBRH_RS05460	COG2223	nitrite transmembrane transporter activity
RBRH_RS05465	COG0789	Transcriptional regulator
RBRH_RS05470	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
RBRH_RS05485	COG0556	nucleotide-excision repair
RBRH_RS05495	COG4633	Protein conserved in bacteria
RBRH_RS05500	COG0672	)-iron permease
RBRH_RS05530	COG0583	DNA-binding transcription factor activity
RBRH_RS05540	COG4166	transmembrane transport
RBRH_RS05545	COG4174	ABC transporter (Permease)
RBRH_RS05550	COG4239	(ABC) transporter, permease
RBRH_RS05555	COG4172	Belongs to the ABC transporter superfamily
RBRH_RS05560	COG0791	NLP P60 protein
RBRH_RS05565	COG1752	Esterase of the alpha-beta hydrolase superfamily
RBRH_RS05590	COG5265	(ABC) transporter
RBRH_RS05610	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
RBRH_RS05615	COG3012	SEC-C Motif Domain Protein
RBRH_RS05620	COG4372	Transposase
RBRH_RS05625	COG3436	PFAM IS66 Orf2 family protein
RBRH_RS05650	COG1487	ribonuclease activity
RBRH_RS05685	COG0534	Mate efflux family protein
RBRH_RS05700	COG3228	Belongs to the MtfA family
RBRH_RS05710	COG0789	Transcriptional regulator
RBRH_RS05715	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
RBRH_RS05730	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
RBRH_RS05745	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
RBRH_RS05775	COG0670	Belongs to the BI1 family
RBRH_RS05785	COG0820	rRNA (adenine-C2-)-methyltransferase activity
RBRH_RS05795	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
RBRH_RS05810	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
RBRH_RS05815	COG1160	GTP binding
RBRH_RS05820	COG1923	regulation of RNA biosynthetic process
RBRH_RS05825	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
RBRH_RS05830	COG0330	HflC and HflK could
RBRH_RS05835	COG0330	HflC and HflK could
RBRH_RS05845	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
RBRH_RS05855	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
RBRH_RS05860	COG3158	transport of potassium into the cell
RBRH_RS05865	COG2183	response to ionizing radiation
RBRH_RS05880	COG1199	ATP-dependent helicase activity
RBRH_RS05890	COG0564	pseudouridine synthase activity
RBRH_RS05895	COG1496	oxidoreductase activity
RBRH_RS05900	COG3243	poly(R)-hydroxyalkanoic acid synthase
RBRH_RS05905	COG0183	Belongs to the thiolase family
RBRH_RS05910	COG1028	Short-chain dehydrogenase reductase Sdr
RBRH_RS05920	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
RBRH_RS05940	COG0560	Phosphoserine phosphatase
RBRH_RS05955	COG0488	(ABC) transporter
RBRH_RS05960	COG0252	asparaginase activity
RBRH_RS05975	COG0360	Binds together with S18 to 16S ribosomal RNA
RBRH_RS05980	COG2965	DNA replication, synthesis of RNA primer
RBRH_RS05990	COG0359	binds to the 23S rRNA
RBRH_RS06005	COG0306	phosphate transporter
RBRH_RS06010	COG0791	NLP P60 protein
RBRH_RS06015	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
RBRH_RS06020	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
RBRH_RS06025	COG0726	polysaccharide deacetylase
RBRH_RS06040	COG0463	Glycosyl transferase, family 2
RBRH_RS06045	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
RBRH_RS06050	COG2076	Multidrug Resistance protein
RBRH_RS06055	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
RBRH_RS06065	COG0436	Aminotransferase
RBRH_RS06085	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
RBRH_RS06090	COG0314	molybdopterin synthase activity
RBRH_RS06115	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
RBRH_RS06125	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
RBRH_RS06130	COG0784	Response regulator, receiver
RBRH_RS06130	COG4191	Histidine kinase
RBRH_RS06140	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
RBRH_RS06155	COG1434	Gram-negative-bacterium-type cell wall biogenesis
RBRH_RS06175	COG0583	DNA-binding transcription factor activity
RBRH_RS06185	COG1187	pseudouridine synthase activity
RBRH_RS06195	COG0779	Required for maturation of 30S ribosomal subunits
RBRH_RS06200	COG0195	Participates in both transcription termination and antitermination
RBRH_RS06200	COG2251	uridine kinase activity
RBRH_RS06205	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
RBRH_RS06230	COG2814	Major facilitator Superfamily
RBRH_RS06235	COG1566	PFAM secretion protein HlyD family protein
RBRH_RS06250	COG1217	gtp-binding protein TYPA
RBRH_RS06260	COG0508	dehydrogenase complex catalyzes the overall conversion of
RBRH_RS06265	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RBRH_RS06270	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
RBRH_RS06305	COG3685	Protein conserved in bacteria
RBRH_RS06330	COG0557	exoribonuclease II activity
RBRH_RS06335	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RBRH_RS06350	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
RBRH_RS06355	COG0488	(ABC) transporter
RBRH_RS06360	COG0386	Belongs to the glutathione peroxidase family
RBRH_RS06370	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RBRH_RS06380	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RBRH_RS06385	COG1393	Belongs to the ArsC family
RBRH_RS06390	COG2171	N-acyltransferase activity
RBRH_RS06395	COG0436	Aminotransferase
RBRH_RS06415	COG0242	peptide deformylase activity
RBRH_RS06445	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
RBRH_RS06455	COG0233	cytoplasmic translational termination
RBRH_RS06460	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
RBRH_RS06470	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
RBRH_RS06475	COG0750	zinc metalloprotease
RBRH_RS06485	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
RBRH_RS06490	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RBRH_RS06500	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RBRH_RS06505	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RBRH_RS06515	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RBRH_RS06520	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
RBRH_RS06570	COG2914	Belongs to the UPF0125 (RnfH) family
RBRH_RS06575	COG0697	spore germination
RBRH_RS06590	COG0519	Catalyzes the synthesis of GMP from XMP
RBRH_RS06590	COG0518	GMP synthase (glutamine-hydrolyzing) activity
RBRH_RS06600	COG2207	Transcriptional regulator
RBRH_RS06605	COG1028	Short-chain dehydrogenase reductase Sdr
RBRH_RS06615	COG0583	DNA-binding transcription factor activity
RBRH_RS06625	COG0655	NAD(P)H dehydrogenase (quinone) activity
RBRH_RS06655	COG0789	Transcriptional regulator
RBRH_RS06660	COG0546	phosphoglycolate phosphatase activity
RBRH_RS06680	COG1278	Cold shock
RBRH_RS06735	COG2070	2-Nitropropane dioxygenase
RBRH_RS06740	COG3979	chitinase
RBRH_RS06745	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
RBRH_RS06750	COG1802	Transcriptional regulator
RBRH_RS06755	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
RBRH_RS06805	COG1902	pentaerythritol trinitrate reductase activity
RBRH_RS06815	COG0583	DNA-binding transcription factor activity
RBRH_RS06835	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
RBRH_RS06860	COG3093	addiction module antidote protein HigA
RBRH_RS06875	COG1487	ribonuclease activity
RBRH_RS06890	COG3547	Transposase (IS116 IS110 IS902 family)
RBRH_RS06915	COG2719	SpoVR family
RBRH_RS06920	COG2718	Belongs to the UPF0229 family
RBRH_RS06925	COG2766	serine protein kinase
RBRH_RS06930	COG1129	ABC transporter
RBRH_RS06950	COG0438	transferase activity, transferring glycosyl groups
RBRH_RS06955	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
RBRH_RS06975	COG0084	hydrolase, TatD family'
RBRH_RS06980	COG1247	-acetyltransferase
RBRH_RS06995	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
RBRH_RS07020	COG2130	NADP-dependent
RBRH_RS07045	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
RBRH_RS07050	COG2917	probably involved in intracellular septation
RBRH_RS07060	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
RBRH_RS07065	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
RBRH_RS07065	COG0047	phosphoribosylformylglycinamidine synthase activity
RBRH_RS07105	COG2814	Major facilitator Superfamily
RBRH_RS07135	COG0776	regulation of translation
RBRH_RS07140	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
RBRH_RS07145	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
RBRH_RS07155	COG0544	peptidyl-prolyl cis-trans isomerase activity
RBRH_RS07200	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
RBRH_RS07205	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
RBRH_RS07210	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
RBRH_RS07235	COG1573	uracil-dna glycosylase
RBRH_RS07315	COG3321	synthase
RBRH_RS07315	COG0300	oxidoreductase activity
RBRH_RS07315	COG4221	oxidoreductase activity
RBRH_RS07315	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
RBRH_RS07320	COG4221	oxidoreductase activity
RBRH_RS07320	COG3321	synthase
RBRH_RS07320	COG0300	oxidoreductase activity
RBRH_RS07320	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
RBRH_RS07325	COG2124	cytochrome p450
RBRH_RS07330	COG1028	Short-chain dehydrogenase reductase Sdr
RBRH_RS07330	COG3321	synthase
RBRH_RS07330	COG4221	oxidoreductase activity
RBRH_RS07330	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
RBRH_RS07335	COG4221	oxidoreductase activity
RBRH_RS07335	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
RBRH_RS07335	COG1028	Short-chain dehydrogenase reductase Sdr
RBRH_RS07335	COG3321	synthase
RBRH_RS07340	COG1028	Short-chain dehydrogenase reductase Sdr
RBRH_RS07340	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RBRH_RS07340	COG3321	synthase
RBRH_RS07340	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
RBRH_RS07340	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
RBRH_RS07345	COG3321	synthase
RBRH_RS07345	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
RBRH_RS07345	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
RBRH_RS07345	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
RBRH_RS07355	COG2226	methyltransferase
RBRH_RS07405	COG2831	hemolysin activation secretion protein
RBRH_RS07410	COG1280	lysine exporter protein (LysE YggA)
RBRH_RS07430	COG1222	aaa ATPase
RBRH_RS07560	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
RBRH_RS07575	COG4251	negative regulation of phosphorylation
RBRH_RS07585	COG0583	DNA-binding transcription factor activity
RBRH_RS07590	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
RBRH_RS07595	COG4208	sulfate ABC transporter
RBRH_RS07600	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
RBRH_RS07605	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
RBRH_RS07610	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
RBRH_RS07685	COG4702	Belongs to the UPF0303 family
RBRH_RS07705	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
RBRH_RS07710	COG0167	dihydroorotate dehydrogenase activity
RBRH_RS07715	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RBRH_RS07720	COG0765	amino acid transport
RBRH_RS07725	COG0438	transferase activity, transferring glycosyl groups
RBRH_RS07740	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
RBRH_RS07795	COG1619	proteins homologs of microcin C7 resistance protein MccF
RBRH_RS07800	COG0590	tRNA wobble adenosine to inosine editing
RBRH_RS07810	COG1562	ergosterol biosynthetic process
RBRH_RS07845	COG0415	Belongs to the DNA photolyase family
RBRH_RS07860	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RBRH_RS07910	COG0308	aminopeptidase N
RBRH_RS07940	COG3685	Protein conserved in bacteria
RBRH_RS07950	COG0243	molybdopterin cofactor binding
RBRH_RS07975	COG0527	aspartate kinase activity
RBRH_RS07980	COG0037	tRNA processing
RBRH_RS07985	COG0825	malonyl-CoA metabolic process
RBRH_RS07995	COG0215	cysteine-tRNA ligase activity
RBRH_RS08005	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
RBRH_RS08010	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
RBRH_RS08015	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RBRH_RS08020	COG1045	serine acetyltransferase
RBRH_RS08025	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
RBRH_RS08030	COG0483	inositol monophosphate 1-phosphatase activity
RBRH_RS08050	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
RBRH_RS08065	COG2850	peptidyl-arginine hydroxylation
RBRH_RS08115	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
RBRH_RS08120	COG1960	acyl-CoA dehydrogenase activity
RBRH_RS08125	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
RBRH_RS08130	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
RBRH_RS08135	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RBRH_RS08145	COG0180	Tryptophanyl-tRNA synthetase
RBRH_RS08150	COG1994	Peptidase M50
RBRH_RS08155	COG0009	L-threonylcarbamoyladenylate synthase
RBRH_RS08160	COG0613	PHP domain protein
RBRH_RS08165	COG0596	Alpha beta hydrolase
RBRH_RS08170	COG2833	Protein of unknown function (DUF455)
RBRH_RS08180	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
RBRH_RS08190	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
RBRH_RS08195	COG0148	phosphopyruvate hydratase activity
RBRH_RS08200	COG2877	3-deoxy-8-phosphooctulonate synthase activity
RBRH_RS08205	COG0504	CTP synthase activity
RBRH_RS08215	COG0352	thiamine-phosphate diphosphorylase activity
RBRH_RS08225	COG0084	hydrolase, TatD family'
RBRH_RS08230	COG1136	(ABC) transporter
RBRH_RS08250	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
RBRH_RS08285	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
RBRH_RS08295	COG0822	iron-sulfur transferase activity
RBRH_RS08300	COG1104	cysteine desulfurase activity
RBRH_RS08310	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
RBRH_RS08315	COG1024	Enoyl-CoA hydratase
RBRH_RS08320	COG0247	lactate metabolic process
RBRH_RS08325	COG1414	Transcriptional regulator
RBRH_RS08340	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RBRH_RS08345	COG0508	dehydrogenase complex catalyzes the overall conversion of
RBRH_RS08350	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
RBRH_RS08360	COG4566	intracellular signal transduction
RBRH_RS08365	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
RBRH_RS08375	COG0402	S-adenosylhomocysteine deaminase activity
RBRH_RS08385	COG2155	Conserved Protein
RBRH_RS08395	COG0708	Exodeoxyribonuclease III
RBRH_RS08410	COG0174	glutamine synthetase
RBRH_RS08420	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RBRH_RS08425	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RBRH_RS08480	COG4942	peptidase
RBRH_RS08545	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
RBRH_RS08555	COG0824	Thioesterase
RBRH_RS08565	COG0848	biopolymer transport protein
RBRH_RS08575	COG0823	Involved in the tonB-independent uptake of proteins
RBRH_RS08595	COG3657	addiction module killer protein
RBRH_RS08600	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
RBRH_RS08620	COG0412	Dienelactone hydrolase
RBRH_RS08635	COG2192	nodulation
RBRH_RS08645	COG4615	Cyclic peptide transporter
RBRH_RS08695	COG3971	2-oxopent-4-enoate hydratase activity
RBRH_RS08700	COG1942	4-Oxalocrotonate Tautomerase
RBRH_RS08715	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
RBRH_RS08750	COG0285	dihydrofolate synthase activity
RBRH_RS08755	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
RBRH_RS08770	COG0133	tryptophan synthase activity
RBRH_RS08775	COG0135	phosphoribosylanthranilate isomerase activity
RBRH_RS08780	COG0101	tRNA pseudouridine synthase activity
RBRH_RS08795	COG0473	3-isopropylmalate dehydrogenase activity
RBRH_RS08800	COG0066	3-isopropylmalate dehydratase activity
RBRH_RS08810	COG0372	Belongs to the citrate synthase family
RBRH_RS08815	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
RBRH_RS08825	COG1053	succinate dehydrogenase
RBRH_RS08830	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
RBRH_RS08840	COG2188	Transcriptional regulator
RBRH_RS08845	COG0039	L-malate dehydrogenase activity
RBRH_RS08860	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
RBRH_RS08880	COG1063	alcohol dehydrogenase
RBRH_RS08905	COG2866	Carboxypeptidase
RBRH_RS08910	COG3022	response to hydroperoxide
RBRH_RS08920	COG0436	Aminotransferase
RBRH_RS08930	COG1024	Enoyl-CoA hydratase
RBRH_RS08935	COG0625	glutathione transferase activity
RBRH_RS08950	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
RBRH_RS08955	COG5265	(ABC) transporter
RBRH_RS08960	COG0391	Required for morphogenesis under gluconeogenic growth conditions
RBRH_RS08965	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
RBRH_RS09015	COG1007	ATP synthesis coupled electron transport
RBRH_RS09030	COG0713	ATP synthesis coupled electron transport
RBRH_RS09045	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
RBRH_RS09050	COG1034	ATP synthesis coupled electron transport
RBRH_RS09065	COG0649	NAD binding
RBRH_RS09070	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RBRH_RS09075	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RBRH_RS09095	COG0149	triose-phosphate isomerase activity
RBRH_RS09105	COG1185	polyribonucleotide nucleotidyltransferase activity
RBRH_RS09110	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
RBRH_RS09115	COG0683	leucine binding
RBRH_RS09125	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
RBRH_RS09130	COG1183	phosphatidylcholine synthase activity
RBRH_RS09135	COG0688	phosphatidylethanolamine metabolic process
RBRH_RS09150	COG0028	Belongs to the TPP enzyme family
RBRH_RS09205	COG0745	RESPONSE REGULATOR receiver
RBRH_RS09210	COG2205	protein histidine kinase activity
RBRH_RS09220	COG1028	Short-chain dehydrogenase reductase Sdr
RBRH_RS09230	COG0217	transcriptional regulatory protein
RBRH_RS09235	COG0151	Belongs to the GarS family
RBRH_RS09240	COG0408	coproporphyrinogen oxidase activity
RBRH_RS09250	COG0799	negative regulation of ribosome biogenesis
RBRH_RS09255	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
RBRH_RS09265	COG1530	ribonuclease E activity
RBRH_RS09285	COG3328	transposase activity
RBRH_RS09325	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
RBRH_RS09330	COG0513	Belongs to the DEAD box helicase family
RBRH_RS09335	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
RBRH_RS09365	COG1309	transcriptional regulator
RBRH_RS09370	COG2878	Part of a membrane complex involved in electron transport
RBRH_RS09375	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
RBRH_RS09405	COG3135	benzoate transporter
RBRH_RS09410	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
RBRH_RS09420	COG2818	Glycosylase
RBRH_RS09430	COG0675	Transposase, IS605 OrfB family
RBRH_RS09480	COG2944	sequence-specific DNA binding
RBRH_RS09505	COG3161	chorismate lyase activity
RBRH_RS09545	COG0488	(ABC) transporter
RBRH_RS09550	COG1773	rubredoxin
RBRH_RS09570	COG1881	PFAM PEBP family protein
RBRH_RS09595	COG1295	ribonuclease BN
RBRH_RS09600	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
RBRH_RS09615	COG2204	response regulator
RBRH_RS09620	COG2204	response regulator
RBRH_RS09630	COG1116	anion transmembrane transporter activity
RBRH_RS09670	COG0837	glucose binding
RBRH_RS09670	COG1737	Transcriptional regulator
RBRH_RS09680	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
RBRH_RS09685	COG1846	Transcriptional regulator
RBRH_RS09690	COG2814	Major facilitator Superfamily
RBRH_RS09695	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
RBRH_RS09700	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
RBRH_RS09700	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
RBRH_RS09725	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
RBRH_RS09735	COG0436	Aminotransferase
RBRH_RS09740	COG0741	lytic transglycosylase activity
RBRH_RS09745	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
RBRH_RS09765	COG0762	integral membrane protein
RBRH_RS09785	COG1968	undecaprenyl-diphosphatase activity
RBRH_RS09805	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
RBRH_RS09810	COG1054	Belongs to the UPF0176 family
RBRH_RS09850	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
RBRH_RS09865	COG3307	-O-antigen
RBRH_RS09875	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
RBRH_RS09955	COG1678	Uncharacterized ACR, COG1678
RBRH_RS09975	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
RBRH_RS09980	COG0540	Belongs to the ATCase OTCase family
RBRH_RS09985	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
RBRH_RS09990	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
RBRH_RS09995	COG1678	Uncharacterized ACR, COG1678
RBRH_RS10015	COG0459	protein refolding
RBRH_RS10020	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
RBRH_RS10035	COG2066	Belongs to the glutaminase family
RBRH_RS10050	COG0583	DNA-binding transcription factor activity
RBRH_RS10060	COG2814	Major facilitator Superfamily
RBRH_RS10090	COG0842	Transport permease protein
RBRH_RS10095	COG1131	(ABC) transporter
RBRH_RS10105	COG1121	(ABC) transporter
RBRH_RS10110	COG1108	ABC-type Mn2 Zn2 transport systems permease components
RBRH_RS10125	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RBRH_RS10150	COG0642	Histidine kinase
RBRH_RS10160	COG2027	D-alanyl-D-alanine carboxypeptidase
RBRH_RS10170	COG0009	L-threonylcarbamoyladenylate synthase
RBRH_RS10175	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
RBRH_RS10180	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
RBRH_RS10185	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
RBRH_RS10200	COG0126	phosphoglycerate kinase activity
RBRH_RS10225	COG0859	PFAM glycosyl transferase family 9
RBRH_RS10235	COG0429	hydrolase of the alpha beta-hydrolase fold
RBRH_RS10245	COG4783	chaperone-mediated protein folding
RBRH_RS10250	COG0315	cyclic pyranopterin monophosphate synthase activity
RBRH_RS10260	COG4969	Belongs to the N-Me-Phe pilin family
RBRH_RS10265	COG0861	Integral membrane protein TerC family
RBRH_RS10270	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
RBRH_RS10285	COG2137	regulation of response to DNA damage stimulus
RBRH_RS10290	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
RBRH_RS10320	COG0628	permease
RBRH_RS10325	COG1914	H( )-stimulated, divalent metal cation uptake system
RBRH_RS10335	COG3546	catalase activity
RBRH_RS10360	COG2863	cytochrome
RBRH_RS10370	COG0513	Belongs to the DEAD box helicase family
RBRH_RS10405	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
RBRH_RS10425	COG1702	phosphate starvation-inducible protein PhoH
RBRH_RS10430	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
RBRH_RS10435	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
RBRH_RS10445	COG0815	Transfers the fatty acyl group on membrane lipoproteins
RBRH_RS10450	COG0752	glycyl-tRNA synthetase alpha subunit
RBRH_RS10455	COG0751	glycine-tRNA ligase activity
RBRH_RS10465	COG0204	Acyl-transferase
RBRH_RS10610	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
RBRH_RS10625	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
RBRH_RS10635	COG0006	proline dipeptidase activity
RBRH_RS10640	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RBRH_RS10650	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
RBRH_RS10655	COG0138	bifunctional purine biosynthesis protein purh
RBRH_RS10660	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
RBRH_RS10665	COG0632	four-way junction helicase activity
RBRH_RS10670	COG2255	four-way junction helicase activity
RBRH_RS10695	COG0316	Belongs to the HesB IscA family
RBRH_RS10710	COG1765	OsmC-like protein
RBRH_RS10720	COG0418	dihydroorotase activity
RBRH_RS10730	COG1126	abc transporter atp-binding protein
RBRH_RS10735	COG0765	amino acid transport
RBRH_RS10740	COG0765	amino acid transport
RBRH_RS10745	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RBRH_RS10750	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
RBRH_RS10755	COG0583	DNA-binding transcription factor activity
RBRH_RS10780	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
RBRH_RS10785	COG1024	Enoyl-CoA hydratase
RBRH_RS10790	COG0183	Belongs to the thiolase family
RBRH_RS10800	COG1960	acyl-CoA dehydrogenase activity
RBRH_RS10810	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RBRH_RS10840	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
RBRH_RS10855	COG2226	methyltransferase
RBRH_RS10880	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
RBRH_RS10885	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
RBRH_RS10885	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
RBRH_RS10900	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
RBRH_RS10905	COG1737	Transcriptional regulator
RBRH_RS10920	COG0477	Major facilitator Superfamily
RBRH_RS10940	COG3344	reverse transcriptase
RBRH_RS10945	COG0629	single-stranded DNA binding
RBRH_RS10950	COG2814	Major facilitator Superfamily
RBRH_RS10980	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
RBRH_RS10995	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
RBRH_RS11010	COG1137	ATPase activity
RBRH_RS11015	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
RBRH_RS11020	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
RBRH_RS11030	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
RBRH_RS11035	COG1660	Displays ATPase and GTPase activities
RBRH_RS11045	COG1194	a g-specific adenine glycosylase
RBRH_RS11050	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
RBRH_RS11075	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
RBRH_RS11080	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
RBRH_RS11090	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
RBRH_RS11095	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
RBRH_RS11100	COG0742	ribosomal rna small subunit methyltransferase
RBRH_RS11140	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
RBRH_RS11155	COG1294	oxidase, subunit
RBRH_RS11180	COG0109	protoheme IX farnesyltransferase activity
RBRH_RS11230	COG2226	methyltransferase
RBRH_RS11235	COG1040	competence protein
RBRH_RS11250	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
RBRH_RS11260	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
RBRH_RS11265	COG0588	phosphoglycerate mutase activity
RBRH_RS11275	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
RBRH_RS11280	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
RBRH_RS11290	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
RBRH_RS11300	COG0189	ligase activity
RBRH_RS11310	COG0004	ammonium transporteR
RBRH_RS11325	COG2960	long-chain fatty acid transporting porin activity
RBRH_RS11360	COG0583	DNA-binding transcription factor activity
RBRH_RS11365	COG2921	Belongs to the UPF0250 family
RBRH_RS11370	COG1686	Belongs to the peptidase S11 family
RBRH_RS11395	COG1127	ABC transporter
RBRH_RS11400	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
RBRH_RS11415	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
RBRH_RS11455	COG1410	methionine synthase
RBRH_RS11455	COG0646	methionine synthase
RBRH_RS11465	COG0018	arginyl-trna synthetase
RBRH_RS11475	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
RBRH_RS11485	COG0747	negative chemotaxis
RBRH_RS11515	COG0288	reversible hydration of carbon dioxide
RBRH_RS11525	COG3012	SEC-C Motif Domain Protein
RBRH_RS11540	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
RBRH_RS11550	COG0635	Involved in the biosynthesis of porphyrin-containing compound
RBRH_RS11585	COG0583	DNA-binding transcription factor activity
RBRH_RS11605	COG3842	ATPase activity
RBRH_RS11610	COG0725	ABC transporter, periplasmic molybdate-binding protein
RBRH_RS11615	COG1028	Short-chain dehydrogenase reductase Sdr
RBRH_RS11650	COG4654	Cytochrome c, class I
RBRH_RS11655	COG2823	Periplasmic or secreted lipoprotein
RBRH_RS11660	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
RBRH_RS11685	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RBRH_RS11695	COG0438	transferase activity, transferring glycosyl groups
RBRH_RS11700	COG1522	sequence-specific DNA binding
RBRH_RS11705	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
RBRH_RS11710	COG2916	Histone family protein nucleoid-structuring protein H-NS
RBRH_RS11735	COG0617	tRNA 3'-terminal CCA addition
RBRH_RS11740	COG0741	lytic transglycosylase activity
RBRH_RS11745	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
RBRH_RS11755	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
RBRH_RS11760	COG1984	allophanate hydrolase subunit 2
RBRH_RS11765	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
RBRH_RS11785	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
RBRH_RS11795	COG4608	Belongs to the ABC transporter superfamily
RBRH_RS11800	COG0444	Belongs to the ABC transporter superfamily
RBRH_RS11805	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RBRH_RS11810	COG0601	transmembrane transport
RBRH_RS11815	COG0747	negative chemotaxis
RBRH_RS11820	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
RBRH_RS11825	COG1950	PFAM Membrane protein of
RBRH_RS11830	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
RBRH_RS11835	COG1346	cytolysis
RBRH_RS11840	COG1380	Effector of murein hydrolase LrgA
RBRH_RS11845	COG0583	DNA-binding transcription factor activity
RBRH_RS11860	COG4774	siderophore transport
RBRH_RS11865	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
RBRH_RS11890	COG1560	Kdo2-lipid A biosynthetic process
RBRH_RS11905	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
RBRH_RS11910	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
RBRH_RS11915	COG0523	cobalamin synthesis protein
RBRH_RS11925	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
RBRH_RS11930	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
RBRH_RS11935	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
RBRH_RS11945	COG0477	Major facilitator Superfamily
RBRH_RS11955	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
RBRH_RS11975	COG2814	Major facilitator Superfamily
RBRH_RS11985	COG0708	Exodeoxyribonuclease III
RBRH_RS12000	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
RBRH_RS12020	COG0768	penicillin binding
RBRH_RS12025	COG0772	Belongs to the SEDS family
RBRH_RS12035	COG0602	queuosine metabolic process
RBRH_RS12045	COG0438	transferase activity, transferring glycosyl groups
RBRH_RS12065	COG3344	reverse transcriptase
RBRH_RS12080	COG2204	response regulator
RBRH_RS12100	COG0501	Belongs to the peptidase M48B family
RBRH_RS12105	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
RBRH_RS12110	COG0242	peptide deformylase activity
RBRH_RS12140	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
RBRH_RS12145	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
RBRH_RS12205	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
RBRH_RS12215	COG0706	membrane insertase activity
RBRH_RS12270	COG1522	sequence-specific DNA binding
RBRH_RS12290	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
RBRH_RS12300	COG0427	acetyl-CoA hydrolase
RBRH_RS12325	COG1254	Belongs to the acylphosphatase family
RBRH_RS12345	COG2084	Dehydrogenase
RBRH_RS12350	COG1960	acyl-CoA dehydrogenase activity
RBRH_RS12360	COG0517	IMP dehydrogenase activity
RBRH_RS12360	COG0516	GMP reductase activity
RBRH_RS12400	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
RBRH_RS12420	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
RBRH_RS12435	COG0745	RESPONSE REGULATOR receiver
RBRH_RS12440	COG1752	Esterase of the alpha-beta hydrolase superfamily
RBRH_RS12445	COG4160	amino acid transport
RBRH_RS12460	COG2223	nitrite transmembrane transporter activity
RBRH_RS12480	COG2916	Histone family protein nucleoid-structuring protein H-NS
RBRH_RS12495	COG1509	lysine 2,3-aminomutase activity
RBRH_RS12615	COG1484	DNA-dependent DNA replication
RBRH_RS12620	COG4584	PFAM Integrase catalytic
RBRH_RS12640	COG0598	Magnesium transport protein CorA
RBRH_RS12645	COG1285	pathogenesis
RBRH_RS12655	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RBRH_RS12660	COG0765	amino acid transport
RBRH_RS12665	COG0765	amino acid transport
RBRH_RS12680	COG4191	Histidine kinase
RBRH_RS12680	COG0784	Response regulator, receiver
RBRH_RS12715	COG2192	nodulation
RBRH_RS12730	COG2205	protein histidine kinase activity
RBRH_RS12740	COG1448	Aminotransferase
RBRH_RS12745	COG1113	amino acid transport
RBRH_RS12770	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
RBRH_RS12795	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
RBRH_RS12805	COG3177	Filamentation induced by cAMP protein fic
RBRH_RS12825	COG2204	response regulator
RBRH_RS12830	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
RBRH_RS12850	COG1596	polysaccharide export
RBRH_RS12865	COG3284	Transcriptional regulator
RBRH_RS12870	COG0745	RESPONSE REGULATOR receiver
RBRH_RS12875	COG3360	Dodecin
RBRH_RS12885	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RBRH_RS12895	COG1309	transcriptional regulator
RBRH_RS12915	COG0038	chloride channel
RBRH_RS12925	COG2855	membrane
RBRH_RS12935	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RBRH_RS12970	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
RBRH_RS12980	COG3047	cAMP biosynthetic process
RBRH_RS13050	COG0668	transmembrane transport
RBRH_RS13055	COG3493	citrate carrier protein
RBRH_RS13065	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
RBRH_RS13085	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
RBRH_RS13095	COG0534	Mate efflux family protein
RBRH_RS13105	COG1970	mechanosensitive ion channel activity
RBRH_RS13175	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
RBRH_RS13175	COG0493	'glutamate synthase
RBRH_RS13200	COG1573	uracil-dna glycosylase
RBRH_RS13360	COG2336	PFAM SpoVT AbrB
RBRH_RS13375	COG3077	Addiction module antitoxin, RelB DinJ family
RBRH_RS13435	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
RBRH_RS13440	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
RBRH_RS13455	COG1960	acyl-CoA dehydrogenase activity
RBRH_RS13505	COG1487	ribonuclease activity
RBRH_RS13515	COG3344	reverse transcriptase
RBRH_RS13525	COG3344	reverse transcriptase
RBRH_RS13535	COG3547	Transposase (IS116 IS110 IS902 family)
RBRH_RS13555	COG1271	oxidase subunit
RBRH_RS13560	COG1294	oxidase, subunit
RBRH_RS13575	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
RBRH_RS13595	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
RBRH_RS13600	COG1074	ATP-dependent DNA helicase activity
RBRH_RS13605	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
RBRH_RS13610	COG1289	transmembrane transporter activity
RBRH_RS13615	COG5002	protein histidine kinase activity
RBRH_RS13620	COG4251	negative regulation of phosphorylation
RBRH_RS13625	COG1058	Belongs to the CinA family
RBRH_RS13625	COG1546	Belongs to the CinA family
RBRH_RS13635	COG1643	Atp-dependent helicase
RBRH_RS13640	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
RBRH_RS13640	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
RBRH_RS13660	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
RBRH_RS13665	COG0477	Major facilitator Superfamily
RBRH_RS13670	COG0351	phosphomethylpyrimidine kinase
RBRH_RS13680	COG1573	uracil-dna glycosylase
RBRH_RS13700	COG0513	Belongs to the DEAD box helicase family
RBRH_RS13705	COG2224	Isocitrate lyase
RBRH_RS13715	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
RBRH_RS13770	COG1309	transcriptional regulator
RBRH_RS13790	COG4191	Histidine kinase
RBRH_RS13790	COG0784	Response regulator, receiver
RBRH_RS13840	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RBRH_RS13850	COG0583	DNA-binding transcription factor activity
RBRH_RS13860	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
RBRH_RS13865	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
RBRH_RS13955	COG3394	polysaccharide catabolic process
RBRH_RS14010	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
RBRH_RS14060	COG0859	PFAM glycosyl transferase family 9
RBRH_RS14075	COG1408	metallophosphoesterase
RBRH_RS14085	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
RBRH_RS14090	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
RBRH_RS14130	COG1024	Enoyl-CoA hydratase
RBRH_RS14130	COG1250	3-hydroxyacyl-CoA dehydrogenase
RBRH_RS14145	COG2814	Major facilitator Superfamily
RBRH_RS14190	COG2851	Citrate transporter
RBRH_RS14225	COG1695	Transcriptional regulator
RBRH_RS14295	COG2201	protein-glutamate methylesterase activity
RBRH_RS14365	COG0330	HflC and HflK could
RBRH_RS14370	COG0492	ferredoxin-NADP+ reductase activity
RBRH_RS14415	COG1562	ergosterol biosynthetic process
RBRH_RS14420	COG1657	PFAM Prenyltransferase squalene oxidase
RBRH_RS14435	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RBRH_RS14470	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
RBRH_RS14475	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
RBRH_RS14480	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
RBRH_RS14480	COG0028	Belongs to the TPP enzyme family
RBRH_RS14490	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
RBRH_RS14525	COG4191	Histidine kinase
RBRH_RS14560	COG0494	nUDIX hydrolase
RBRH_RS14570	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
RBRH_RS14575	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
RBRH_RS14580	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
RBRH_RS14585	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
RBRH_RS14610	COG0517	IMP dehydrogenase activity
RBRH_RS14615	COG1573	uracil-dna glycosylase
RBRH_RS14660	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
RBRH_RS14680	COG1024	Enoyl-CoA hydratase
RBRH_RS14685	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
RBRH_RS14690	COG1960	acyl-CoA dehydrogenase activity
RBRH_RS14745	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
RBRH_RS14760	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
RBRH_RS14760	COG1024	Enoyl-CoA hydratase
RBRH_RS14780	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
RBRH_RS14790	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
RBRH_RS14815	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RBRH_RS14825	COG4943	cyclic-guanylate-specific phosphodiesterase activity
RBRH_RS14860	COG2207	Transcriptional regulator
RBRH_RS14875	COG4791	protein targeting
RBRH_RS14890	COG1317	bacterial-type flagellum organization
RBRH_RS14915	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
RBRH_RS14920	COG4789	Type iii secretion
RBRH_RS15000	COG1917	Cupin 2, conserved barrel domain protein
RBRH_RS15020	COG1063	alcohol dehydrogenase
RBRH_RS15050	COG1192	Involved in chromosome partitioning
RBRH_RS15065	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
RBRH_RS15085	COG0583	DNA-binding transcription factor activity
RBRH_RS15090	COG0657	acetylesterase activity
RBRH_RS15110	COG0438	transferase activity, transferring glycosyl groups
RBRH_RS15120	COG3284	Transcriptional regulator
RBRH_RS15125	COG3199	ATP-NAD kinase
RBRH_RS15130	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
RBRH_RS15145	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
RBRH_RS15160	COG2181	nitrate reductase activity
RBRH_RS15220	COG0450	alkyl hydroperoxide reductase
RBRH_RS15225	COG3634	alkyl hydroperoxide reductase activity
RBRH_RS15255	COG1115	amino acid carrier protein
RBRH_RS15325	COG1475	DNA binding
RBRH_RS15350	COG4974	Belongs to the 'phage' integrase family
RBRH_RS15375	COG1192	Involved in chromosome partitioning
RBRH_RS15380	COG1475	DNA binding
RBRH_RS15495	COG3657	addiction module killer protein
RBRH_RS15500	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
RBRH_RS15530	COG2201	protein-glutamate methylesterase activity
RBRH_RS15570	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
RBRH_RS15590	COG0681	Belongs to the peptidase S26 family
RBRH_RS15650	COG0501	Belongs to the peptidase M48B family
RBRH_RS15695	COG1484	DNA-dependent DNA replication
RBRH_RS15730	COG0587	DNA-directed DNA polymerase activity
RBRH_RS15775	COG3609	addiction module antidote protein, CC2985 family
RBRH_RS15820	COG3093	addiction module antidote protein HigA
RBRH_RS15840	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
RBRH_RS15855	COG3493	citrate carrier protein
RBRH_RS15895	COG4974	Belongs to the 'phage' integrase family
RBRH_RS15910	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RBRH_RS15940	COG2337	Toxic component of a toxin-antitoxin (TA) module
RBRH_RS15945	COG2336	PFAM SpoVT AbrB
RBRH_RS16025	COG1484	DNA-dependent DNA replication
RBRH_RS16030	COG4584	PFAM Integrase catalytic
RBRH_RS16135	COG0181	hydroxymethylbilane synthase activity
RBRH_RS16225	COG3210	domain, Protein
RBRH_RS16280	COG2264	protein methyltransferase activity
RBRH_RS16375	COG2264	protein methyltransferase activity
RBRH_RS16385	COG2264	protein methyltransferase activity
RBRH_RS16395	COG0484	heat shock protein binding
RBRH_RS16710	COG5487	UPF0391 membrane protein
RBRH_RS16750	COG1674	ftsk spoiiie
RBRH_RS17130	COG0183	Belongs to the thiolase family
RBRH_RS17140	COG1187	pseudouridine synthase activity
RBRH_RS17190	COG3537	Alpha-1,2-mannosidase
RBRH_RS17195	COG3537	Alpha-1,2-mannosidase
RBRH_RS17455	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
RBRH_RS17695	COG3077	Addiction module antitoxin, RelB DinJ family
RBRH_RS17840	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
RBRH_RS18135	COG2986	histidine ammonia-lyase
RBRH_RS18140	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
RBRH_RS18175	COG5295	Hep Hag repeat protein
RBRH_RS18415	COG2916	Histone family protein nucleoid-structuring protein H-NS
RBRH_RS18675	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
RBRH_RS18765	COG0635	Involved in the biosynthesis of porphyrin-containing compound
RBRH_RS18840	COG3537	Alpha-1,2-mannosidase
RBRH_RS18940	COG3493	citrate carrier protein
RBRH_RS18960	COG2079	MmgE PrpD family protein
RBRH_RS18985	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RBRH_RS19025	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
RBRH_RS19050	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RBRH_RS19170	COG3724	N-succinylarginine dihydrolase activity
RBRH_RS19230	COG0589	response to stress
RBRH_RS19310	COG1214	PFAM Peptidase M22, glycoprotease
RBRH_RS19625	COG2176	DNA-directed DNA polymerase activity
RBRH_RS19640	COG2801	Transposase and inactivated derivatives
RBRH_RS19760	COG3328	transposase activity
RBRH_RS19800	COG2963	transposase activity