locus-tag	class	description
CAK77_RS00015	COG0592	DNA-directed DNA polymerase activity
CAK77_RS00020	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
CAK77_RS00025	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CAK77_RS00030	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
CAK77_RS00035	COG0187	DNA topoisomerase II activity
CAK77_RS00185	COG0640	Transcriptional regulator
CAK77_RS00220	COG2132	Multicopper oxidase
CAK77_RS00255	COG0596	Alpha beta hydrolase
CAK77_RS00275	COG2814	Major facilitator Superfamily
CAK77_RS00280	COG0583	DNA-binding transcription factor activity
CAK77_RS00295	COG0705	Rhomboid family
CAK77_RS00295	COG0457	Tetratricopeptide repeat
CAK77_RS00325	COG0515	serine threonine protein kinase
CAK77_RS00325	COG2815	serine threonine protein kinase
CAK77_RS00330	COG0515	serine threonine protein kinase
CAK77_RS00335	COG0768	penicillin binding
CAK77_RS00350	COG1716	ATPase activity
CAK77_RS00355	COG1716	ATPase activity
CAK77_RS00380	COG0754	glutathionylspermidine amidase activity
CAK77_RS00390	COG1309	transcriptional regulator
CAK77_RS00410	COG4842	Belongs to the WXG100 family
CAK77_RS00430	COG0590	tRNA wobble adenosine to inosine editing
CAK77_RS00440	COG0583	DNA-binding transcription factor activity
CAK77_RS00445	COG1643	Atp-dependent helicase
CAK77_RS00450	COG1028	Short-chain dehydrogenase reductase Sdr
CAK77_RS00480	COG1960	acyl-CoA dehydrogenase activity
CAK77_RS00525	COG2072	flavoprotein involved in K transport
CAK77_RS00535	COG0346	lactoylglutathione lyase activity
CAK77_RS00540	COG1414	Transcriptional regulator
CAK77_RS00560	COG1053	succinate dehydrogenase
CAK77_RS00590	COG1785	Belongs to the alkaline phosphatase family
CAK77_RS00615	COG0070	glutamate synthase
CAK77_RS00615	COG0069	glutamate synthase activity
CAK77_RS00615	COG0067	glutamate synthase
CAK77_RS00645	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CAK77_RS00645	COG1796	DNA polymerase
CAK77_RS00655	COG2072	flavoprotein involved in K transport
CAK77_RS00665	COG2124	cytochrome p450
CAK77_RS00710	COG2372	response to copper ion
CAK77_RS00765	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CAK77_RS00785	COG3447	MASE1 domain protein
CAK77_RS00785	COG5001	Diguanylate cyclase
CAK77_RS00785	COG5002	protein histidine kinase activity
CAK77_RS00795	COG1528	Iron-storage protein
CAK77_RS00800	COG1528	Iron-storage protein
CAK77_RS00805	COG1316	TRANSCRIPTIONal
CAK77_RS00830	COG0406	alpha-ribazole phosphatase activity
CAK77_RS00840	COG0028	Belongs to the TPP enzyme family
CAK77_RS00855	COG2072	flavoprotein involved in K transport
CAK77_RS00875	COG2072	flavoprotein involved in K transport
CAK77_RS00895	COG1285	pathogenesis
CAK77_RS00945	COG2146	nitrite reductase [NAD(P)H] activity
CAK77_RS00945	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CAK77_RS00955	COG4133	protoheme IX ABC transporter activity
CAK77_RS00960	COG2070	2-Nitropropane dioxygenase
CAK77_RS00965	COG1942	4-Oxalocrotonate Tautomerase
CAK77_RS00970	COG0583	DNA-binding transcription factor activity
CAK77_RS00985	COG1028	Short-chain dehydrogenase reductase Sdr
CAK77_RS00990	COG0204	Acyl-transferase
CAK77_RS01000	COG0561	phosphatase activity
CAK77_RS01020	COG1216	Glycosyl transferase, family 2
CAK77_RS01025	COG0671	phosphoesterase, PA-phosphatase related
CAK77_RS01030	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CAK77_RS01035	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CAK77_RS01055	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
CAK77_RS01060	COG0318	PFAM AMP-dependent synthetase and ligase
CAK77_RS01065	COG3321	synthase
CAK77_RS01065	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
CAK77_RS01065	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CAK77_RS01070	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CAK77_RS01120	COG1028	Short-chain dehydrogenase reductase Sdr
CAK77_RS01125	COG0277	FAD linked oxidase domain protein
CAK77_RS01135	COG2376	Dihydroxyacetone kinase
CAK77_RS01140	COG2267	carboxylic ester hydrolase activity
CAK77_RS01145	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CAK77_RS01150	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CAK77_RS01165	COG0671	phosphoesterase, PA-phosphatase related
CAK77_RS01175	COG1216	Glycosyl transferase, family 2
CAK77_RS01240	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CAK77_RS01245	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CAK77_RS01315	COG1960	acyl-CoA dehydrogenase activity
CAK77_RS01330	COG1028	Short-chain dehydrogenase reductase Sdr
CAK77_RS01350	COG1174	glycine betaine transport
CAK77_RS01365	COG0287	Prephenate dehydrogenase
CAK77_RS01375	COG0590	tRNA wobble adenosine to inosine editing
CAK77_RS01400	COG0343	queuine tRNA-ribosyltransferase activity
CAK77_RS01405	COG2124	cytochrome p450
CAK77_RS01410	COG0765	amino acid transport
CAK77_RS01415	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CAK77_RS01420	COG1793	dna ligase
CAK77_RS01465	COG2271	Major facilitator Superfamily
CAK77_RS01470	COG0604	alcohol dehydrogenase
CAK77_RS01520	COG1028	Short-chain dehydrogenase reductase Sdr
CAK77_RS01555	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CAK77_RS01580	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CAK77_RS01590	COG0148	phosphopyruvate hydratase activity
CAK77_RS01620	COG0860	N-Acetylmuramoyl-L-alanine amidase
CAK77_RS01635	COG1492	cobalamin metabolic process
CAK77_RS01660	COG1960	acyl-CoA dehydrogenase activity
CAK77_RS01675	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CAK77_RS01705	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CAK77_RS01750	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CAK77_RS01760	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CAK77_RS01790	COG2070	2-Nitropropane dioxygenase
CAK77_RS01830	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CAK77_RS01835	COG2971	BadF BadG BcrA BcrD
CAK77_RS01840	COG2814	Major facilitator Superfamily
CAK77_RS01860	COG3572	ergothioneine biosynthetic process
CAK77_RS01865	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CAK77_RS01870	COG0121	glutamine amidotransferase
CAK77_RS01875	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
CAK77_RS01880	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CAK77_RS01910	COG2030	dehydratase
CAK77_RS01915	COG1028	Short-chain dehydrogenase reductase Sdr
CAK77_RS01920	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CAK77_RS01930	COG1695	Transcriptional regulator
CAK77_RS01940	COG0475	glutathione-regulated potassium exporter activity
CAK77_RS01940	COG0569	domain protein
CAK77_RS01960	COG0714	Associated with various cellular activities
CAK77_RS02000	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CAK77_RS02005	COG1074	ATP-dependent DNA helicase activity
CAK77_RS02010	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
CAK77_RS02020	COG2755	lipolytic protein G-D-S-L family
CAK77_RS02245	COG4974	Belongs to the 'phage' integrase family
CAK77_RS02255	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CAK77_RS02260	COG1408	metallophosphoesterase
CAK77_RS02265	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CAK77_RS02295	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CAK77_RS02335	COG0596	Alpha beta hydrolase
CAK77_RS02335	COG2945	thiolester hydrolase activity
CAK77_RS02350	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CAK77_RS02355	COG0747	negative chemotaxis
CAK77_RS02365	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CAK77_RS02405	COG0640	Transcriptional regulator
CAK77_RS02530	COG1695	Transcriptional regulator
CAK77_RS02535	COG0657	acetylesterase activity
CAK77_RS02540	COG1902	pentaerythritol trinitrate reductase activity
CAK77_RS02545	COG1205	dead DEAH box helicase
CAK77_RS02545	COG1111	helicase
CAK77_RS02550	COG1278	Cold shock
CAK77_RS02560	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CAK77_RS02560	COG1754	DNA topoisomerase type I activity
CAK77_RS02675	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CAK77_RS02710	COG2027	D-alanyl-D-alanine carboxypeptidase
CAK77_RS02740	COG1063	alcohol dehydrogenase
CAK77_RS02750	COG2267	carboxylic ester hydrolase activity
CAK77_RS02760	COG1309	transcriptional regulator
CAK77_RS02775	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CAK77_RS02820	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CAK77_RS02830	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CAK77_RS02850	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CAK77_RS02855	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CAK77_RS02895	COG4977	sequence-specific DNA binding
CAK77_RS02900	COG1194	a g-specific adenine glycosylase
CAK77_RS02910	COG1316	TRANSCRIPTIONal
CAK77_RS02920	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
CAK77_RS02930	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CAK77_RS02950	COG1329	Transcriptional regulator
CAK77_RS02955	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CAK77_RS02965	COG0215	cysteine-tRNA ligase activity
CAK77_RS02975	COG0584	glycerophosphoryl diester phosphodiesterase
CAK77_RS02985	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CAK77_RS02990	COG1120	ATPase activity
CAK77_RS02995	COG0803	Belongs to the bacterial solute-binding protein 9 family
CAK77_RS03005	COG1309	transcriptional regulator
CAK77_RS03010	COG1960	acyl-CoA dehydrogenase activity
CAK77_RS03025	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CAK77_RS03035	COG0346	lactoylglutathione lyase activity
CAK77_RS03075	COG1960	acyl-CoA dehydrogenase activity
CAK77_RS03085	COG1960	acyl-CoA dehydrogenase activity
CAK77_RS03090	COG0318	PFAM AMP-dependent synthetase and ligase
CAK77_RS03095	COG1960	acyl-CoA dehydrogenase activity
CAK77_RS03110	COG0183	Belongs to the thiolase family
CAK77_RS03140	COG1024	Enoyl-CoA hydratase
CAK77_RS03145	COG1028	Short-chain dehydrogenase reductase Sdr
CAK77_RS03150	COG1028	Short-chain dehydrogenase reductase Sdr
CAK77_RS03170	COG0183	Belongs to the thiolase family
CAK77_RS03180	COG1960	acyl-CoA dehydrogenase activity
CAK77_RS03185	COG1960	acyl-CoA dehydrogenase activity
CAK77_RS03190	COG2030	dehydratase
CAK77_RS03215	COG2030	dehydratase
CAK77_RS03220	COG1053	succinate dehydrogenase
CAK77_RS03230	COG3971	2-oxopent-4-enoate hydratase activity
CAK77_RS03280	COG0651	ATP synthesis coupled electron transport
CAK77_RS03290	COG2111	Na H antiporter
CAK77_RS03290	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CAK77_RS03295	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CAK77_RS03315	COG0647	UMP catabolic process
CAK77_RS03350	COG4221	oxidoreductase activity
CAK77_RS03370	COG0459	protein refolding
CAK77_RS03385	COG0714	Associated with various cellular activities
CAK77_RS03435	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CAK77_RS03450	COG4842	Belongs to the WXG100 family
CAK77_RS03495	COG0745	RESPONSE REGULATOR receiver
CAK77_RS03500	COG5000	phosphorelay sensor kinase activity
CAK77_RS03500	COG5002	protein histidine kinase activity
CAK77_RS03505	COG0537	adenosine 5'-monophosphoramidase activity
CAK77_RS03510	COG0697	spore germination
CAK77_RS03520	COG0596	Alpha beta hydrolase
CAK77_RS03550	COG0436	Aminotransferase
CAK77_RS03560	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CAK77_RS03585	COG0477	Major facilitator Superfamily
CAK77_RS03590	COG0386	Belongs to the glutathione peroxidase family
CAK77_RS03600	COG3573	Dehydrogenase
CAK77_RS03610	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CAK77_RS03625	COG2837	iron assimilation
CAK77_RS03630	COG1362	aminopeptidase activity
CAK77_RS03705	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CAK77_RS03715	COG0601	transmembrane transport
CAK77_RS03720	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CAK77_RS03725	COG4172	Belongs to the ABC transporter superfamily
CAK77_RS03740	COG0604	alcohol dehydrogenase
CAK77_RS03745	COG1309	transcriptional regulator
CAK77_RS03785	COG1902	pentaerythritol trinitrate reductase activity
CAK77_RS03805	COG1028	Short-chain dehydrogenase reductase Sdr
CAK77_RS03880	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CAK77_RS03910	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CAK77_RS03920	COG0354	folic acid binding
CAK77_RS03975	COG2897	thiosulfate sulfurtransferase activity
CAK77_RS03995	COG0745	RESPONSE REGULATOR receiver
CAK77_RS04015	COG0581	inorganic phosphate transmembrane transporter activity
CAK77_RS04020	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CAK77_RS04025	COG0604	alcohol dehydrogenase
CAK77_RS04080	COG1250	3-hydroxyacyl-CoA dehydrogenase
CAK77_RS04105	COG0697	spore germination
CAK77_RS04125	COG0442	prolyl-tRNA aminoacylation
CAK77_RS04130	COG2814	Major facilitator Superfamily
CAK77_RS04165	COG5651	PPE family
CAK77_RS04170	COG0436	Aminotransferase
CAK77_RS04180	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CAK77_RS04185	COG1960	acyl-CoA dehydrogenase activity
CAK77_RS04190	COG1012	belongs to the aldehyde dehydrogenase family
CAK77_RS04195	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CAK77_RS04210	COG1028	Short-chain dehydrogenase reductase Sdr
CAK77_RS04225	COG1028	Short-chain dehydrogenase reductase Sdr
CAK77_RS04240	COG1024	Enoyl-CoA hydratase
CAK77_RS04285	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CAK77_RS04290	COG0657	acetylesterase activity
CAK77_RS04310	COG0183	Belongs to the thiolase family
CAK77_RS04325	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CAK77_RS04345	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CAK77_RS04360	COG1061	Type III restriction enzyme res subunit
CAK77_RS04400	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CAK77_RS04425	COG1278	Cold shock
CAK77_RS04465	COG2814	Major facilitator Superfamily
CAK77_RS04540	COG1764	response to oxidative stress
CAK77_RS04545	COG1846	Transcriptional regulator
CAK77_RS04550	COG1216	Glycosyl transferase, family 2
CAK77_RS04555	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CAK77_RS04555	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CAK77_RS04585	COG0259	pyridoxamine-phosphate oxidase activity
CAK77_RS04595	COG0318	PFAM AMP-dependent synthetase and ligase
CAK77_RS04600	COG5651	PPE family
CAK77_RS04605	COG2409	Drug exporters of the RND superfamily
CAK77_RS04630	COG4977	sequence-specific DNA binding
CAK77_RS04650	COG1846	Transcriptional regulator
CAK77_RS04655	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CAK77_RS04665	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CAK77_RS04670	COG0833	amino acid
CAK77_RS04685	COG2186	Transcriptional regulator
CAK77_RS04690	COG0545	Peptidyl-prolyl cis-trans isomerase
CAK77_RS04730	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CAK77_RS04735	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
CAK77_RS04780	COG1012	belongs to the aldehyde dehydrogenase family
CAK77_RS04795	COG3022	response to hydroperoxide
CAK77_RS04805	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CAK77_RS04840	COG1309	transcriptional regulator
CAK77_RS04900	COG1309	transcriptional regulator
CAK77_RS04975	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CAK77_RS04980	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CAK77_RS04990	COG1393	Belongs to the ArsC family
CAK77_RS04995	COG0583	DNA-binding transcription factor activity
CAK77_RS05035	COG0183	Belongs to the thiolase family
CAK77_RS05080	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CAK77_RS05120	COG0438	transferase activity, transferring glycosyl groups
CAK77_RS05130	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CAK77_RS05145	COG2382	esterase
CAK77_RS05175	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
CAK77_RS05180	COG1846	Transcriptional regulator
CAK77_RS05230	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CAK77_RS05240	COG2326	polyphosphate kinase activity
CAK77_RS05260	COG0523	cobalamin synthesis protein
CAK77_RS05265	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CAK77_RS05270	COG0235	Class ii aldolase
CAK77_RS05275	COG1396	sequence-specific DNA binding
CAK77_RS05280	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CAK77_RS05285	COG0166	Belongs to the GPI family
CAK77_RS05330	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CAK77_RS05385	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CAK77_RS05415	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CAK77_RS05420	COG0315	cyclic pyranopterin monophosphate synthase activity
CAK77_RS05420	COG0521	Mo-molybdopterin cofactor biosynthetic process
CAK77_RS05455	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CAK77_RS05460	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CAK77_RS05505	COG1063	alcohol dehydrogenase
CAK77_RS05555	COG2235	arginine
CAK77_RS05570	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CAK77_RS05585	COG1252	NADH dehydrogenase
CAK77_RS05595	COG0084	hydrolase, TatD family'
CAK77_RS05600	COG3583	domain protein
CAK77_RS05615	COG0515	serine threonine protein kinase
CAK77_RS05615	COG2815	serine threonine protein kinase
CAK77_RS05635	COG0456	acetyltransferase
CAK77_RS05635	COG1846	Transcriptional regulator
CAK77_RS05640	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CAK77_RS05645	COG0318	PFAM AMP-dependent synthetase and ligase
CAK77_RS05660	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CAK77_RS05695	COG1309	transcriptional regulator
CAK77_RS05740	COG3956	TIGRFAM MazG family protein
CAK77_RS05755	COG2837	iron assimilation
CAK77_RS05760	COG2822	iron ion transport
CAK77_RS05795	COG0596	Alpha beta hydrolase
CAK77_RS05820	COG0318	PFAM AMP-dependent synthetase and ligase
CAK77_RS05890	COG0427	acetyl-CoA hydrolase
CAK77_RS05945	COG1846	Transcriptional regulator
CAK77_RS05960	COG1024	Enoyl-CoA hydratase
CAK77_RS05985	COG0183	Belongs to the thiolase family
CAK77_RS05990	COG2755	lipolytic protein G-D-S-L family
CAK77_RS05995	COG0657	acetylesterase activity
CAK77_RS06005	COG1714	RDD family
CAK77_RS06020	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CAK77_RS06040	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CAK77_RS06050	COG1331	Highly conserved protein containing a thioredoxin domain
CAK77_RS06055	COG3631	Ketosteroid isomerase-related protein
CAK77_RS06070	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CAK77_RS06075	COG1028	Short-chain dehydrogenase reductase Sdr
CAK77_RS06080	COG2124	cytochrome p450
CAK77_RS06100	COG1028	Short-chain dehydrogenase reductase Sdr
CAK77_RS06140	COG2272	Belongs to the type-B carboxylesterase lipase family
CAK77_RS06150	COG1174	glycine betaine transport
CAK77_RS06155	COG1125	glycine betaine transport
CAK77_RS06155	COG0517	IMP dehydrogenase activity
CAK77_RS06160	COG1174	glycine betaine transport
CAK77_RS06205	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CAK77_RS06215	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CAK77_RS06220	COG0726	polysaccharide deacetylase
CAK77_RS06295	COG1570	exodeoxyribonuclease VII activity
CAK77_RS06305	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CAK77_RS06320	COG1966	Carbon starvation protein
CAK77_RS06345	COG3189	MarR family transcriptional regulator
CAK77_RS06350	COG0012	GTP binding
CAK77_RS06375	COG2132	Multicopper oxidase
CAK77_RS06385	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CAK77_RS06395	COG0488	(ABC) transporter
CAK77_RS06450	COG2409	Drug exporters of the RND superfamily
CAK77_RS06485	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CAK77_RS06505	COG1716	ATPase activity
CAK77_RS06535	COG1051	belongs to the nudix hydrolase family
CAK77_RS06565	COG1217	gtp-binding protein TYPA
CAK77_RS06575	COG2015	COG2015, Alkyl sulfatase and related hydrolases
CAK77_RS06645	COG1902	pentaerythritol trinitrate reductase activity
CAK77_RS06645	COG0446	pyridine nucleotide-disulphide oxidoreductase
CAK77_RS06655	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CAK77_RS06665	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CAK77_RS06670	COG1012	belongs to the aldehyde dehydrogenase family
CAK77_RS06675	COG0506	proline dehydrogenase activity
CAK77_RS06680	COG0318	PFAM AMP-dependent synthetase and ligase
CAK77_RS06705	COG2207	Transcriptional regulator
CAK77_RS06720	COG1611	Belongs to the LOG family
CAK77_RS06725	COG1611	Belongs to the LOG family
CAK77_RS06730	COG0318	PFAM AMP-dependent synthetase and ligase
CAK77_RS06740	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CAK77_RS06750	COG0463	Glycosyl transferase, family 2
CAK77_RS06765	COG0519	Catalyzes the synthesis of GMP from XMP
CAK77_RS06775	COG0297	glycogen (starch) synthase activity
CAK77_RS06800	COG3559	Exporter of polyketide antibiotics
CAK77_RS06805	COG1131	(ABC) transporter
CAK77_RS06810	COG1309	transcriptional regulator
CAK77_RS06820	COG1595	DNA-templated transcription, initiation
CAK77_RS06825	COG5662	AntiSigma factor
CAK77_RS06830	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CAK77_RS06900	COG0598	Magnesium transport protein CorA
CAK77_RS06905	COG1309	transcriptional regulator
CAK77_RS06925	COG2095	MarC family integral membrane protein
CAK77_RS06940	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CAK77_RS06945	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CAK77_RS06965	COG3835	regulator
CAK77_RS06970	COG1073	alpha beta
CAK77_RS06975	COG0567	Dehydrogenase, E1 component
CAK77_RS06975	COG0508	dehydrogenase complex catalyzes the overall conversion of
CAK77_RS06985	COG2814	Major facilitator Superfamily
CAK77_RS07045	COG0277	FAD linked oxidase domain protein
CAK77_RS07050	COG1028	Short-chain dehydrogenase reductase Sdr
CAK77_RS07065	COG0668	transmembrane transport
CAK77_RS07160	COG2814	Major facilitator Superfamily
CAK77_RS07190	COG0019	diaminopimelate decarboxylase activity
CAK77_RS07195	COG0460	homoserine dehydrogenase
CAK77_RS07200	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CAK77_RS07240	COG2890	protein-(glutamine-N5) methyltransferase activity
CAK77_RS07250	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CAK77_RS07260	COG0356	it plays a direct role in the translocation of protons across the membrane
CAK77_RS07265	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CAK77_RS07290	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CAK77_RS07355	COG0346	lactoylglutathione lyase activity
CAK77_RS07360	COG0183	Belongs to the thiolase family
CAK77_RS07365	COG2409	Drug exporters of the RND superfamily
CAK77_RS07380	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CAK77_RS07385	COG0366	Alpha amylase catalytic
CAK77_RS07390	COG0058	SHG alpha-glucan phosphorylase activity
CAK77_RS07405	COG1335	isochorismatase
CAK77_RS07415	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CAK77_RS07430	COG3191	aminopeptidase activity
CAK77_RS07475	COG0604	alcohol dehydrogenase
CAK77_RS07495	COG0318	PFAM AMP-dependent synthetase and ligase
CAK77_RS07510	COG0419	ATPase involved in DNA repair
CAK77_RS07515	COG1024	Enoyl-CoA hydratase
CAK77_RS07525	COG0243	molybdopterin cofactor binding
CAK77_RS07540	COG2188	Transcriptional regulator
CAK77_RS07600	COG0596	Alpha beta hydrolase
CAK77_RS07605	COG3757	hydrolase, family 25
CAK77_RS07625	COG1051	belongs to the nudix hydrolase family
CAK77_RS07645	COG1309	transcriptional regulator
CAK77_RS07660	COG4585	Histidine kinase
CAK77_RS07665	COG2197	response regulator
CAK77_RS07675	COG2239	Acts as a magnesium transporter
CAK77_RS07685	COG0300	oxidoreductase activity
CAK77_RS07695	COG0656	L-ascorbic acid biosynthetic process
CAK77_RS07710	COG1376	ErfK ybiS ycfS ynhG family protein
CAK77_RS07725	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
CAK77_RS07730	COG0433	COG0433 Predicted ATPase
CAK77_RS07745	COG0300	oxidoreductase activity
CAK77_RS07760	COG1301	dicarboxylic acid transport
CAK77_RS07770	COG0531	amino acid
CAK77_RS07790	COG4424	Sulfotransferase
CAK77_RS07795	COG3119	arylsulfatase activity
CAK77_RS07835	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CAK77_RS07835	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CAK77_RS07875	COG2902	Dehydrogenase
CAK77_RS07880	COG0824	Thioesterase
CAK77_RS07895	COG0366	Alpha amylase catalytic
CAK77_RS07930	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CAK77_RS07950	COG1309	transcriptional regulator
CAK77_RS08080	COG0740	serine-type endopeptidase activity
CAK77_RS08085	COG0740	serine-type endopeptidase activity
CAK77_RS08135	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CAK77_RS08145	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CAK77_RS08145	COG0674	pyruvate-flavodoxin oxidoreductase activity
CAK77_RS08150	COG1013	pyruvate-flavodoxin oxidoreductase activity
CAK77_RS08160	COG1388	LysM domain
CAK77_RS08190	COG0525	valine-tRNA ligase activity
CAK77_RS08195	COG0285	dihydrofolate synthase activity
CAK77_RS08210	COG1530	ribonuclease E activity
CAK77_RS08230	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CAK77_RS08250	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CAK77_RS08255	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CAK77_RS08260	COG0542	response to heat
CAK77_RS08270	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CAK77_RS08280	COG0406	alpha-ribazole phosphatase activity
CAK77_RS08285	COG2755	lipolytic protein G-D-S-L family
CAK77_RS08305	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CAK77_RS08340	COG2308	Evidence 4 Homologs of previously reported genes of
CAK77_RS08350	COG1305	Transglutaminase-like
CAK77_RS08380	COG3387	PFAM Glycoside hydrolase 15-related
CAK77_RS08395	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CAK77_RS08430	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
CAK77_RS08435	COG4208	sulfate ABC transporter
CAK77_RS08490	COG0484	heat shock protein binding
CAK77_RS08590	COG0076	glutamate decarboxylase activity
CAK77_RS08625	COG0318	PFAM AMP-dependent synthetase and ligase
CAK77_RS08630	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CAK77_RS08675	COG0423	glycine-tRNA ligase activity
CAK77_RS08680	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CAK77_RS08685	COG2515	1-aminocyclopropane-1-carboxylate deaminase
CAK77_RS08705	COG0358	DNA primase activity
CAK77_RS08765	COG1175	transmembrane transport
CAK77_RS08780	COG0745	RESPONSE REGULATOR receiver
CAK77_RS08785	COG5002	protein histidine kinase activity
CAK77_RS08845	COG3038	cytochrome b561
CAK77_RS08875	COG0488	(ABC) transporter
CAK77_RS08900	COG1960	acyl-CoA dehydrogenase activity
CAK77_RS08905	COG1335	isochorismatase
CAK77_RS08915	COG0058	SHG alpha-glucan phosphorylase activity
CAK77_RS08955	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CAK77_RS08960	COG1960	acyl-CoA dehydrogenase activity
CAK77_RS08965	COG0183	Belongs to the thiolase family
CAK77_RS08985	COG1228	amidohydrolase
CAK77_RS09035	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CAK77_RS09065	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CAK77_RS09110	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CAK77_RS09180	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
CAK77_RS09185	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
CAK77_RS09245	COG0714	Associated with various cellular activities
CAK77_RS09280	COG0318	PFAM AMP-dependent synthetase and ligase
CAK77_RS09305	COG0174	glutamine synthetase
CAK77_RS09310	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
CAK77_RS09340	COG2205	protein histidine kinase activity
CAK77_RS09390	COG0174	glutamine synthetase
CAK77_RS09400	COG0477	Major facilitator Superfamily
CAK77_RS09410	COG3486	L-lysine 6-monooxygenase (NADPH) activity
CAK77_RS09430	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CAK77_RS09435	COG0321	lipoyl(octanoyl) transferase activity
CAK77_RS09450	COG1872	DUF167
CAK77_RS09465	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CAK77_RS09470	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CAK77_RS09480	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
CAK77_RS09485	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CAK77_RS09515	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CAK77_RS09565	COG2010	Cytochrome c
CAK77_RS09570	COG1845	cytochrome c oxidase, subunit III
CAK77_RS09610	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CAK77_RS09635	COG0003	Pfam Anion-transporting ATPase
CAK77_RS09645	COG0204	Acyl-transferase
CAK77_RS09650	COG5650	phosphatidylinositol metabolic process
CAK77_RS09660	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
CAK77_RS09685	COG0142	geranyltranstransferase activity
CAK77_RS09725	COG0768	penicillin binding
CAK77_RS09745	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CAK77_RS09755	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CAK77_RS09770	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CAK77_RS09795	COG0640	Transcriptional regulator
CAK77_RS09845	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CAK77_RS09855	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CAK77_RS09865	COG1028	Short-chain dehydrogenase reductase Sdr
CAK77_RS09895	COG2814	Major facilitator Superfamily
CAK77_RS09975	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CAK77_RS09980	COG2030	dehydratase
CAK77_RS10000	COG1024	Enoyl-CoA hydratase
CAK77_RS10015	COG1309	transcriptional regulator
CAK77_RS10035	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CAK77_RS10080	COG2072	flavoprotein involved in K transport
CAK77_RS10095	COG0318	PFAM AMP-dependent synthetase and ligase
CAK77_RS10100	COG1960	acyl-CoA dehydrogenase activity
CAK77_RS10120	COG1960	acyl-CoA dehydrogenase activity
CAK77_RS10130	COG2801	Transposase and inactivated derivatives
CAK77_RS10155	COG3621	Patatin-like phospholipase
CAK77_RS10215	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CAK77_RS10245	COG1968	undecaprenyl-diphosphatase activity
CAK77_RS10280	COG1218	3'(2'),5'-bisphosphate nucleotidase
CAK77_RS10290	COG1028	Short-chain dehydrogenase reductase Sdr
CAK77_RS10315	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CAK77_RS10325	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
CAK77_RS10325	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CAK77_RS10340	COG2860	membrane
CAK77_RS10350	COG0646	methionine synthase
CAK77_RS10350	COG1410	methionine synthase
CAK77_RS10355	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CAK77_RS10365	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CAK77_RS10400	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
CAK77_RS10405	COG1034	ATP synthesis coupled electron transport
CAK77_RS10410	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CAK77_RS10415	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CAK77_RS10455	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CAK77_RS10455	COG1017	nitric oxide dioxygenase activity
CAK77_RS10505	COG0513	Belongs to the DEAD box helicase family
CAK77_RS10540	COG0028	Belongs to the TPP enzyme family
CAK77_RS10555	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CAK77_RS10560	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
CAK77_RS10565	COG4122	O-methyltransferase activity
CAK77_RS10595	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CAK77_RS10600	COG4521	taurine ABC transporter
CAK77_RS10605	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
CAK77_RS10645	COG2378	regulation of single-species biofilm formation
CAK77_RS10650	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CAK77_RS10685	COG0300	oxidoreductase activity
CAK77_RS10740	COG1574	metal-dependent hydrolase with the TIM-barrel fold
CAK77_RS10750	COG0463	Glycosyl transferase, family 2
CAK77_RS10780	COG3321	synthase
CAK77_RS10780	COG1028	Short-chain dehydrogenase reductase Sdr
CAK77_RS10780	COG0604	alcohol dehydrogenase
CAK77_RS10800	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CAK77_RS10810	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CAK77_RS10815	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CAK77_RS10835	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
CAK77_RS10845	COG1404	Belongs to the peptidase S8 family
CAK77_RS10860	COG4842	Belongs to the WXG100 family
CAK77_RS10890	COG0464	growth
CAK77_RS10910	COG0583	DNA-binding transcription factor activity
CAK77_RS10940	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CAK77_RS10945	COG1169	isochorismate synthase
CAK77_RS10950	COG0789	Transcriptional regulator
CAK77_RS10955	COG1021	2,3-dihydroxybenzoate-AMP ligase
CAK77_RS10985	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
CAK77_RS10990	COG1132	(ABC) transporter
CAK77_RS10995	COG1132	(ABC) transporter
CAK77_RS10995	COG2375	cellular response to nickel ion
CAK77_RS11000	COG0477	Major facilitator Superfamily
CAK77_RS11005	COG5285	phytanoyl-CoA dioxygenase
CAK77_RS11015	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CAK77_RS11020	COG0456	acetyltransferase
CAK77_RS11035	COG2837	iron assimilation
CAK77_RS11045	COG2186	Transcriptional regulator
CAK77_RS11050	COG2807	transmembrane transport
CAK77_RS11060	COG2409	Drug exporters of the RND superfamily
CAK77_RS11065	COG3629	intracellular signal transduction
CAK77_RS11070	COG1012	belongs to the aldehyde dehydrogenase family
CAK77_RS11110	COG0475	glutathione-regulated potassium exporter activity
CAK77_RS11180	COG0237	dephospho-CoA kinase activity
CAK77_RS11180	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
CAK77_RS11360	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CAK77_RS11365	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CAK77_RS11365	COG0072	phenylalanine-tRNA ligase activity
CAK77_RS11375	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CAK77_RS11380	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CAK77_RS11385	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CAK77_RS11390	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CAK77_RS11395	COG1438	arginine binding
CAK77_RS11400	COG0137	argininosuccinate synthase activity
CAK77_RS11440	COG2835	tetraacyldisaccharide 4'-kinase activity
CAK77_RS11445	COG1309	transcriptional regulator
CAK77_RS11450	COG2094	Belongs to the DNA glycosylase MPG family
CAK77_RS11465	COG0488	(ABC) transporter
CAK77_RS11475	COG0647	UMP catabolic process
CAK77_RS11490	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CAK77_RS11510	COG0504	CTP synthase activity
CAK77_RS11515	COG0494	nUDIX hydrolase
CAK77_RS11530	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CAK77_RS11535	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CAK77_RS11550	COG1160	GTP binding
CAK77_RS11560	COG1403	HNH endonuclease
CAK77_RS11600	COG3976	FMN-binding domain protein
CAK77_RS11600	COG1053	succinate dehydrogenase
CAK77_RS11630	COG1960	acyl-CoA dehydrogenase activity
CAK77_RS11685	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CAK77_RS11685	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CAK77_RS11700	COG1253	flavin adenine dinucleotide binding
CAK77_RS11705	COG1253	flavin adenine dinucleotide binding
CAK77_RS11715	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CAK77_RS11770	COG0832	Belongs to the urease beta subunit family
CAK77_RS11780	COG0830	nickel cation binding
CAK77_RS11795	COG1252	NADH dehydrogenase
CAK77_RS11805	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CAK77_RS11840	COG0243	molybdopterin cofactor binding
CAK77_RS11850	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CAK77_RS11865	COG1058	Belongs to the CinA family
CAK77_RS11865	COG1546	Belongs to the CinA family
CAK77_RS11875	COG4977	sequence-specific DNA binding
CAK77_RS11880	COG1741	Belongs to the pirin family
CAK77_RS11905	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
CAK77_RS11930	COG0277	FAD linked oxidase domain protein
CAK77_RS11940	COG1309	transcriptional regulator
CAK77_RS11955	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CAK77_RS11960	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CAK77_RS11965	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CAK77_RS11990	COG4290	ribonuclease
CAK77_RS12025	COG3883	PFAM NLP P60 protein
CAK77_RS12025	COG0791	NLP P60 protein
CAK77_RS12060	COG0477	Major facilitator Superfamily
CAK77_RS12080	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CAK77_RS12085	COG0067	glutamate synthase
CAK77_RS12085	COG0069	glutamate synthase activity
CAK77_RS12085	COG0070	glutamate synthase
CAK77_RS12115	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CAK77_RS12130	COG1960	acyl-CoA dehydrogenase activity
CAK77_RS12145	COG0443	Heat shock 70 kDa protein
CAK77_RS12150	COG0596	Alpha beta hydrolase
CAK77_RS12170	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CAK77_RS12180	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
CAK77_RS12205	COG2890	protein-(glutamine-N5) methyltransferase activity
CAK77_RS12275	COG1982	Orn Lys Arg decarboxylase major
CAK77_RS12335	COG1309	transcriptional regulator
CAK77_RS12340	COG2957	Belongs to the agmatine deiminase family
CAK77_RS12355	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CAK77_RS12415	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
CAK77_RS12430	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
CAK77_RS12485	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
CAK77_RS12535	COG0640	Transcriptional regulator
CAK77_RS12545	COG0798	PFAM Bile acid sodium symporter
CAK77_RS12550	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CAK77_RS12575	COG0789	Transcriptional regulator
CAK77_RS12585	COG0300	oxidoreductase activity
CAK77_RS12610	COG0732	type I restriction modification DNA specificity domain
CAK77_RS12615	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
CAK77_RS12620	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
CAK77_RS12645	COG4974	Belongs to the 'phage' integrase family
CAK77_RS12665	COG3328	transposase activity
CAK77_RS12700	COG0745	RESPONSE REGULATOR receiver
CAK77_RS12705	COG2205	protein histidine kinase activity
CAK77_RS12725	COG1917	Cupin 2, conserved barrel domain protein
CAK77_RS12730	COG3707	response regulator
CAK77_RS12770	COG3467	pyridoxamine 5'-phosphate
CAK77_RS12795	COG0640	Transcriptional regulator
CAK77_RS12815	COG1309	transcriptional regulator
CAK77_RS12820	COG2072	flavoprotein involved in K transport
CAK77_RS12830	COG0318	PFAM AMP-dependent synthetase and ligase
CAK77_RS12835	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CAK77_RS12840	COG0561	phosphatase activity
CAK77_RS12845	COG0673	inositol 2-dehydrogenase activity
CAK77_RS12850	COG0738	Major facilitator superfamily
CAK77_RS12940	COG1271	oxidase subunit
CAK77_RS12945	COG1294	oxidase, subunit
CAK77_RS12950	COG4988	ABC transporter
CAK77_RS12955	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CAK77_RS12980	COG1946	Acyl-CoA thioesterase
CAK77_RS12990	COG2076	Multidrug Resistance protein
CAK77_RS13025	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CAK77_RS13030	COG1846	Transcriptional regulator
CAK77_RS13065	COG0483	inositol monophosphate 1-phosphatase activity
CAK77_RS13075	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CAK77_RS13080	COG0131	Imidazoleglycerol-phosphate dehydratase
CAK77_RS13085	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CAK77_RS13110	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CAK77_RS13125	COG1309	transcriptional regulator
CAK77_RS13140	COG0583	DNA-binding transcription factor activity
CAK77_RS13145	COG0579	oxidoreductase
CAK77_RS13185	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CAK77_RS13185	COG2755	lipolytic protein G-D-S-L family
CAK77_RS13250	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CAK77_RS13255	COG2814	Major facilitator Superfamily
CAK77_RS13260	COG0583	DNA-binding transcription factor activity
CAK77_RS13305	COG1914	H( )-stimulated, divalent metal cation uptake system
CAK77_RS13310	COG2239	Acts as a magnesium transporter
CAK77_RS13335	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CAK77_RS13345	COG2304	oxidoreductase activity
CAK77_RS13355	COG0714	Associated with various cellular activities
CAK77_RS13365	COG3883	PFAM NLP P60 protein
CAK77_RS13365	COG0791	NLP P60 protein
CAK77_RS13375	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CAK77_RS13380	COG1309	transcriptional regulator
CAK77_RS13405	COG0488	(ABC) transporter
CAK77_RS13420	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CAK77_RS13435	COG0456	acetyltransferase
CAK77_RS13445	COG2151	metal-sulfur cluster biosynthetic enzyme
CAK77_RS13460	COG0396	ATPase activity
CAK77_RS13485	COG1131	(ABC) transporter
CAK77_RS13525	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CAK77_RS13585	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CAK77_RS13645	COG0531	amino acid
CAK77_RS13700	COG2011	ABC-type metal ion transport system permease component
CAK77_RS13705	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CAK77_RS13725	COG0477	Major facilitator Superfamily
CAK77_RS13760	COG0657	acetylesterase activity
CAK77_RS13765	COG1953	Uracil, thiamine, allantoin
CAK77_RS13775	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CAK77_RS13780	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CAK77_RS13790	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CAK77_RS13800	COG1758	RNA polymerase activity
CAK77_RS13820	COG0284	orotidine-5'-phosphate decarboxylase activity
CAK77_RS13825	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CAK77_RS13830	COG0505	Belongs to the CarA family
CAK77_RS13850	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CAK77_RS13870	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CAK77_RS13880	COG0006	proline dipeptidase activity
CAK77_RS13895	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CAK77_RS13900	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CAK77_RS13915	COG4106	trans-aconitate 2-methyltransferase activity
CAK77_RS13930	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CAK77_RS13945	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CAK77_RS13995	COG0701	Predicted permease
CAK77_RS14020	COG2272	Belongs to the type-B carboxylesterase lipase family
CAK77_RS14060	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CAK77_RS14070	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CAK77_RS14080	COG0747	negative chemotaxis
CAK77_RS14085	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CAK77_RS14100	COG2255	four-way junction helicase activity
CAK77_RS14110	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CAK77_RS14145	COG1946	Acyl-CoA thioesterase
CAK77_RS14150	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
CAK77_RS14160	COG0438	transferase activity, transferring glycosyl groups
CAK77_RS14200	COG4762	Protein conserved in bacteria
CAK77_RS14230	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CAK77_RS14250	COG4585	Histidine kinase
CAK77_RS14335	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
CAK77_RS14410	COG3383	formate dehydrogenase (NAD+) activity
CAK77_RS14435	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CAK77_RS14445	COG2217	Heavy metal translocating P-type atpase
CAK77_RS14460	COG2132	Multicopper oxidase
CAK77_RS14575	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CAK77_RS14590	COG2080	2 iron, 2 sulfur cluster binding
CAK77_RS14590	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CAK77_RS14605	COG0402	S-adenosylhomocysteine deaminase activity
CAK77_RS14625	COG2233	PERMEase
CAK77_RS14645	COG1953	Uracil, thiamine, allantoin
CAK77_RS14655	COG1301	dicarboxylic acid transport
CAK77_RS14665	COG4266	Belongs to the allantoicase family
CAK77_RS14695	COG0501	Belongs to the peptidase M48B family
CAK77_RS14710	COG0477	Major facilitator Superfamily
CAK77_RS14725	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CAK77_RS14765	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CAK77_RS14775	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CAK77_RS14815	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CAK77_RS14845	COG3253	May function as heme-dependent peroxidase
CAK77_RS14850	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
CAK77_RS14855	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CAK77_RS14865	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
CAK77_RS14885	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CAK77_RS14890	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CAK77_RS14895	COG0531	amino acid
CAK77_RS14900	COG0569	domain protein
CAK77_RS14935	COG0702	epimerase
CAK77_RS14950	COG0756	dUTP diphosphatase activity
CAK77_RS14995	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CAK77_RS15005	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CAK77_RS15045	COG3220	belongs to the UPF0276 family
CAK77_RS15120	COG1388	LysM domain
CAK77_RS15135	COG1960	acyl-CoA dehydrogenase activity
CAK77_RS15145	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CAK77_RS15165	COG1196	nuclear chromosome segregation
CAK77_RS15185	COG1126	abc transporter atp-binding protein
CAK77_RS15190	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CAK77_RS15195	COG0765	amino acid transport
CAK77_RS15200	COG0765	amino acid transport
CAK77_RS15250	COG4308	Limonene-1,2-epoxide hydrolase catalytic domain
CAK77_RS15255	COG4308	Limonene-1,2-epoxide hydrolase catalytic domain
CAK77_RS15270	COG1842	Phage shock protein A
CAK77_RS15275	COG1396	sequence-specific DNA binding
CAK77_RS15285	COG1028	Short-chain dehydrogenase reductase Sdr
CAK77_RS15295	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
CAK77_RS15350	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CAK77_RS15355	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CAK77_RS15370	COG3214	Protein conserved in bacteria
CAK77_RS15420	COG0659	secondary active sulfate transmembrane transporter activity
CAK77_RS15430	COG0686	Belongs to the AlaDH PNT family
CAK77_RS15495	COG2977	Belongs to the P-Pant transferase superfamily
CAK77_RS15500	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CAK77_RS15520	COG1960	acyl-CoA dehydrogenase activity
CAK77_RS15525	COG1960	acyl-CoA dehydrogenase activity
CAK77_RS15530	COG1024	Enoyl-CoA hydratase
CAK77_RS15555	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CAK77_RS15580	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CAK77_RS15580	COG1017	nitric oxide dioxygenase activity
CAK77_RS15585	COG1959	2 iron, 2 sulfur cluster binding
CAK77_RS15630	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CAK77_RS15630	COG1648	precorrin-2 dehydrogenase activity
CAK77_RS15655	COG1028	Short-chain dehydrogenase reductase Sdr
CAK77_RS15655	COG0604	alcohol dehydrogenase
CAK77_RS15655	COG3321	synthase
CAK77_RS15720	COG0579	oxidoreductase
CAK77_RS15740	COG1492	cobalamin metabolic process
CAK77_RS15750	COG1376	ErfK ybiS ycfS ynhG family protein
CAK77_RS15775	COG0750	zinc metalloprotease
CAK77_RS15800	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CAK77_RS15840	COG0412	Dienelactone hydrolase
CAK77_RS15865	COG0528	UMP kinase activity
CAK77_RS15870	COG3973	AAA domain
CAK77_RS15885	COG2723	6-phospho-beta-galactosidase activity
CAK77_RS15920	COG1309	transcriptional regulator
CAK77_RS15960	COG0583	DNA-binding transcription factor activity
CAK77_RS16050	COG0336	Belongs to the RNA methyltransferase TrmD family
CAK77_RS16090	COG1686	Belongs to the peptidase S11 family
CAK77_RS16110	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CAK77_RS16130	COG1304	FMN binding
CAK77_RS16155	COG1254	Belongs to the acylphosphatase family
CAK77_RS16180	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
CAK77_RS16185	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
CAK77_RS16205	COG0571	ribonuclease III activity
CAK77_RS16215	COG3599	regulation of cell shape
CAK77_RS16260	COG0742	ribosomal rna small subunit methyltransferase
CAK77_RS16265	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CAK77_RS16280	COG0657	acetylesterase activity
CAK77_RS16285	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CAK77_RS16305	COG2124	cytochrome p450
CAK77_RS16320	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CAK77_RS16325	COG1461	Dihydroxyacetone kinase
CAK77_RS16335	COG1024	Enoyl-CoA hydratase
CAK77_RS16360	COG1181	Belongs to the D-alanine--D-alanine ligase family
CAK77_RS16365	COG0626	cystathionine gamma-synthase activity
CAK77_RS16370	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CAK77_RS16435	COG0179	Fumarylacetoacetate (FAA) hydrolase
CAK77_RS16450	COG2271	Major facilitator Superfamily
CAK77_RS16470	COG1309	transcriptional regulator
CAK77_RS16480	COG2124	cytochrome p450
CAK77_RS16515	COG0440	acetolactate synthase activity
CAK77_RS16530	COG1748	Saccharopine dehydrogenase
CAK77_RS16535	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CAK77_RS16555	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CAK77_RS16575	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CAK77_RS16585	COG2272	Belongs to the type-B carboxylesterase lipase family
CAK77_RS16600	COG0745	RESPONSE REGULATOR receiver
CAK77_RS16605	COG2205	protein histidine kinase activity
CAK77_RS16630	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CAK77_RS16660	COG1024	Enoyl-CoA hydratase
CAK77_RS16665	COG0778	Nitroreductase
CAK77_RS16675	COG2252	PERMEase
CAK77_RS16715	COG2197	response regulator
CAK77_RS16720	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CAK77_RS16730	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CAK77_RS16755	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CAK77_RS16800	COG0110	maltose O-acetyltransferase activity
CAK77_RS16805	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CAK77_RS16830	COG1119	ATPase activity
CAK77_RS16840	COG2364	Membrane
CAK77_RS16845	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CAK77_RS16860	COG4607	ABC-type enterochelin transport system periplasmic component
CAK77_RS16910	COG1064	alcohol dehydrogenase
CAK77_RS16930	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CAK77_RS16935	COG1028	Short-chain dehydrogenase reductase Sdr
CAK77_RS17025	COG0477	Major facilitator Superfamily
CAK77_RS17045	COG1028	Short-chain dehydrogenase reductase Sdr
CAK77_RS17075	COG1028	Short-chain dehydrogenase reductase Sdr
CAK77_RS17100	COG1335	isochorismatase
CAK77_RS17110	COG2855	membrane
CAK77_RS17120	COG0318	PFAM AMP-dependent synthetase and ligase
CAK77_RS17135	COG1028	Short-chain dehydrogenase reductase Sdr
CAK77_RS17140	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CAK77_RS17205	COG2272	Belongs to the type-B carboxylesterase lipase family
CAK77_RS17210	COG2272	Belongs to the type-B carboxylesterase lipase family
CAK77_RS17220	COG0183	Belongs to the thiolase family
CAK77_RS17255	COG1309	transcriptional regulator
CAK77_RS17285	COG0789	Transcriptional regulator
CAK77_RS17295	COG0028	Belongs to the TPP enzyme family
CAK77_RS17400	COG2177	Part of the ABC transporter FtsEX involved in
CAK77_RS17405	COG2884	Cell division ATP-binding protein ftsE
CAK77_RS17415	COG0668	transmembrane transport
CAK77_RS17455	COG0483	inositol monophosphate 1-phosphatase activity
CAK77_RS17460	COG1960	acyl-CoA dehydrogenase activity
CAK77_RS17465	COG1960	acyl-CoA dehydrogenase activity
CAK77_RS17480	COG0318	PFAM AMP-dependent synthetase and ligase
CAK77_RS17490	COG0542	response to heat
CAK77_RS17535	COG3480	Lon protease (S16) C-terminal proteolytic domain
CAK77_RS17540	COG3011	Protein conserved in bacteria
CAK77_RS17555	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CAK77_RS17560	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CAK77_RS17565	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CAK77_RS17600	COG0475	glutathione-regulated potassium exporter activity
CAK77_RS17600	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CAK77_RS17615	COG0596	Alpha beta hydrolase
CAK77_RS17630	COG0745	RESPONSE REGULATOR receiver
CAK77_RS17640	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CAK77_RS17640	COG2146	nitrite reductase [NAD(P)H] activity
CAK77_RS17645	COG2223	nitrite transmembrane transporter activity
CAK77_RS17685	COG0513	Belongs to the DEAD box helicase family
CAK77_RS17700	COG0406	alpha-ribazole phosphatase activity
CAK77_RS17720	COG1597	lipid kinase activity
CAK77_RS17735	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CAK77_RS17750	COG1595	DNA-templated transcription, initiation
CAK77_RS17760	COG2135	peptidase activity
CAK77_RS17765	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CAK77_RS17770	COG1162	GTPase activity
CAK77_RS17800	COG0653	protein targeting
CAK77_RS17810	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CAK77_RS17815	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CAK77_RS17825	COG1309	transcriptional regulator
CAK77_RS17840	COG5401	PFAM Sporulation and spore germination
CAK77_RS17845	COG5002	protein histidine kinase activity
CAK77_RS17855	COG0318	PFAM AMP-dependent synthetase and ligase
CAK77_RS17860	COG1285	pathogenesis
CAK77_RS17900	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CAK77_RS17905	COG0531	amino acid
CAK77_RS17915	COG1482	cell wall glycoprotein biosynthetic process
CAK77_RS17945	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CAK77_RS17950	COG0778	Nitroreductase
CAK77_RS17950	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
CAK77_RS17965	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CAK77_RS17980	COG1316	TRANSCRIPTIONal
CAK77_RS18000	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CAK77_RS18010	COG2175	clavaminate synthase activity
CAK77_RS18035	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CAK77_RS18035	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CAK77_RS18045	COG0318	PFAM AMP-dependent synthetase and ligase
CAK77_RS18060	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CAK77_RS18070	COG0424	maF-like protein
CAK77_RS18085	COG2226	methyltransferase
CAK77_RS18095	COG3265	gluconokinase activity
CAK77_RS18100	COG1960	acyl-CoA dehydrogenase activity
CAK77_RS18115	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CAK77_RS18140	COG4770	biotin carboxylase activity
CAK77_RS18175	COG1012	belongs to the aldehyde dehydrogenase family
CAK77_RS18180	COG1309	transcriptional regulator
CAK77_RS18185	COG1201	RNA secondary structure unwinding
CAK77_RS18200	COG0564	pseudouridine synthase activity
CAK77_RS18220	COG1473	amidohydrolase
CAK77_RS18220	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
CAK77_RS18235	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CAK77_RS18250	COG3883	PFAM NLP P60 protein
CAK77_RS18250	COG0791	NLP P60 protein
CAK77_RS18295	COG2009	succinate dehydrogenase
CAK77_RS18310	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CAK77_RS18315	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CAK77_RS18320	COG1595	DNA-templated transcription, initiation
CAK77_RS18335	COG1686	Belongs to the peptidase S11 family
CAK77_RS18350	COG0708	Exodeoxyribonuclease III
CAK77_RS18410	COG1733	regulation of RNA biosynthetic process
CAK77_RS18415	COG2910	NAD(P)H-binding
CAK77_RS18420	COG1131	(ABC) transporter
CAK77_RS18420	COG1716	ATPase activity
CAK77_RS18420	COG0842	Transport permease protein
CAK77_RS18425	COG1357	PFAM Pentapeptide repeats (8 copies)
CAK77_RS18430	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CAK77_RS18435	COG0587	DNA-directed DNA polymerase activity
CAK77_RS18440	COG1073	alpha beta
CAK77_RS18445	COG1309	transcriptional regulator
CAK77_RS18510	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CAK77_RS18510	COG0519	Catalyzes the synthesis of GMP from XMP
CAK77_RS18520	COG0516	GMP reductase activity
CAK77_RS18615	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CAK77_RS18630	COG0456	acetyltransferase
CAK77_RS18650	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CAK77_RS18655	COG0076	glutamate decarboxylase activity
CAK77_RS18665	COG2267	carboxylic ester hydrolase activity
CAK77_RS18670	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CAK77_RS18695	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CAK77_RS18705	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CAK77_RS18710	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CAK77_RS18745	COG1404	Belongs to the peptidase S8 family
CAK77_RS18775	COG2267	carboxylic ester hydrolase activity
CAK77_RS18830	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CAK77_RS18835	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CAK77_RS18845	COG2268	Band 7 protein
CAK77_RS18855	COG1088	dTDP-glucose 4,6-dehydratase activity
CAK77_RS18860	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
CAK77_RS18905	COG0616	signal peptide processing
CAK77_RS18940	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CAK77_RS18950	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CAK77_RS18965	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CAK77_RS18980	COG2272	Belongs to the type-B carboxylesterase lipase family
CAK77_RS19005	COG0477	Major facilitator Superfamily
CAK77_RS19020	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CAK77_RS19060	COG0088	Forms part of the polypeptide exit tunnel
CAK77_RS19065	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CAK77_RS19070	COG0051	transcription antitermination factor activity, RNA binding
CAK77_RS19110	COG0531	amino acid
CAK77_RS19140	COG0535	radical SAM domain protein
CAK77_RS19165	COG1834	amidinotransferase
CAK77_RS19170	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CAK77_RS19175	COG0531	amino acid
CAK77_RS19220	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CAK77_RS19225	COG1309	transcriptional regulator
CAK77_RS19250	COG1024	Enoyl-CoA hydratase
CAK77_RS19265	COG1960	acyl-CoA dehydrogenase activity
CAK77_RS19295	COG1113	amino acid transport
CAK77_RS19310	COG0085	RNA polymerase activity
CAK77_RS19315	COG0243	molybdopterin cofactor binding
CAK77_RS19375	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CAK77_RS19390	COG0277	FAD linked oxidase domain protein
CAK77_RS19410	COG4941	Belongs to the sigma-70 factor family
CAK77_RS19445	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CAK77_RS19485	COG0783	Belongs to the Dps family
CAK77_RS19490	COG0693	protein deglycase activity
CAK77_RS19535	COG1404	Belongs to the peptidase S8 family
CAK77_RS19600	COG1280	lysine exporter protein (LysE YggA)
CAK77_RS19670	COG0501	Belongs to the peptidase M48B family
CAK77_RS19675	COG0142	geranyltranstransferase activity
CAK77_RS19680	COG0644	oxidoreductase
CAK77_RS19690	COG0438	transferase activity, transferring glycosyl groups
CAK77_RS19710	COG4948	Mandelate Racemase Muconate Lactonizing
CAK77_RS19730	COG3706	GGDEF domain
CAK77_RS19745	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CAK77_RS19755	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CAK77_RS19760	COG1028	Short-chain dehydrogenase reductase Sdr
CAK77_RS19765	COG4221	oxidoreductase activity
CAK77_RS19815	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
CAK77_RS19820	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CAK77_RS19830	COG0542	response to heat
CAK77_RS19860	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CAK77_RS19905	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CAK77_RS19915	COG0785	Cytochrome C biogenesis protein
CAK77_RS19925	COG0406	alpha-ribazole phosphatase activity
CAK77_RS19945	COG3590	peptidase
CAK77_RS19990	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CAK77_RS19990	COG1587	Uroporphyrinogen-III synthase
CAK77_RS20015	COG2030	dehydratase
CAK77_RS20040	COG2070	2-Nitropropane dioxygenase
CAK77_RS20065	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CAK77_RS20070	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CAK77_RS20160	COG2072	flavoprotein involved in K transport
CAK77_RS20185	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CAK77_RS20235	COG2072	flavoprotein involved in K transport
CAK77_RS20250	COG2072	flavoprotein involved in K transport
CAK77_RS20255	COG1028	Short-chain dehydrogenase reductase Sdr
CAK77_RS20260	COG0657	acetylesterase activity
CAK77_RS20265	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CAK77_RS20275	COG0745	RESPONSE REGULATOR receiver
CAK77_RS20280	COG5002	protein histidine kinase activity
CAK77_RS20290	COG2072	flavoprotein involved in K transport
CAK77_RS20305	COG0300	oxidoreductase activity
CAK77_RS20365	COG2814	Major facilitator Superfamily
CAK77_RS20370	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CAK77_RS20465	COG2733	membrane
CAK77_RS20475	COG2326	polyphosphate kinase activity
CAK77_RS20480	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CAK77_RS20515	COG2224	Isocitrate lyase
CAK77_RS20565	COG2226	methyltransferase
CAK77_RS20615	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CAK77_RS20650	COG0667	Aldo Keto reductase
CAK77_RS20675	COG4552	Acetyltransferase involved in intracellular survival and related
CAK77_RS20680	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CAK77_RS20705	COG1505	serine-type exopeptidase activity
CAK77_RS20725	COG2326	polyphosphate kinase activity
CAK77_RS20740	COG2223	nitrite transmembrane transporter activity
CAK77_RS20745	COG0640	Transcriptional regulator
CAK77_RS20775	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
CAK77_RS20795	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CAK77_RS20820	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CAK77_RS20825	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CAK77_RS20830	COG1028	Short-chain dehydrogenase reductase Sdr
CAK77_RS20840	COG1960	acyl-CoA dehydrogenase activity
CAK77_RS20845	COG1960	acyl-CoA dehydrogenase activity
CAK77_RS20850	COG0318	PFAM AMP-dependent synthetase and ligase
CAK77_RS20860	COG2070	2-Nitropropane dioxygenase
CAK77_RS20870	COG1024	Enoyl-CoA hydratase
CAK77_RS20880	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CAK77_RS20915	COG4638	Rieske (2fe-2S)
CAK77_RS20955	COG0175	sulfate reduction
CAK77_RS21025	COG2814	Major facilitator Superfamily
CAK77_RS21035	COG0351	phosphomethylpyrimidine kinase
CAK77_RS21045	COG1252	NADH dehydrogenase
CAK77_RS21055	COG1309	transcriptional regulator
CAK77_RS21065	COG1012	belongs to the aldehyde dehydrogenase family
CAK77_RS21100	COG0494	nUDIX hydrolase
CAK77_RS21110	COG2234	aminopeptidase activity
CAK77_RS21115	COG2234	aminopeptidase activity
CAK77_RS21125	COG1131	(ABC) transporter
CAK77_RS21130	COG2022	thiamine diphosphate biosynthetic process
CAK77_RS21165	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CAK77_RS21170	COG0515	serine threonine protein kinase
CAK77_RS21175	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CAK77_RS21205	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CAK77_RS21210	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CAK77_RS21215	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CAK77_RS21220	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CAK77_RS21230	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CAK77_RS21235	COG1126	abc transporter atp-binding protein
CAK77_RS21240	COG0765	amino acid transport
CAK77_RS21275	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
CAK77_RS21300	COG0415	Belongs to the DNA photolyase family
CAK77_RS21305	COG1090	epimerase
CAK77_RS21315	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CAK77_RS21330	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CAK77_RS21340	COG1595	DNA-templated transcription, initiation
CAK77_RS21365	COG1994	Peptidase M50
CAK77_RS21385	COG0586	Pfam SNARE associated Golgi protein
CAK77_RS21415	COG4221	oxidoreductase activity
CAK77_RS21435	COG0542	response to heat
CAK77_RS21465	COG0789	Transcriptional regulator
CAK77_RS21475	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CAK77_RS21560	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CAK77_RS21560	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CAK77_RS21580	COG2259	Doxx family
CAK77_RS21600	COG0247	lactate metabolic process
CAK77_RS21600	COG2181	nitrate reductase activity
CAK77_RS21610	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CAK77_RS21650	COG3345	alpha-galactosidase
CAK77_RS21655	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CAK77_RS21660	COG1305	Transglutaminase-like
CAK77_RS21675	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CAK77_RS21750	COG1012	belongs to the aldehyde dehydrogenase family
CAK77_RS21815	COG1028	Short-chain dehydrogenase reductase Sdr
CAK77_RS21820	COG1960	acyl-CoA dehydrogenase activity
CAK77_RS21835	COG3268	Saccharopine dehydrogenase
CAK77_RS21840	COG0318	PFAM AMP-dependent synthetase and ligase
CAK77_RS21845	COG3285	dna ligase
CAK77_RS21845	COG1793	dna ligase
CAK77_RS21855	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CAK77_RS21860	COG0318	PFAM AMP-dependent synthetase and ligase
CAK77_RS21900	COG1309	transcriptional regulator
CAK77_RS21905	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
CAK77_RS21920	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CAK77_RS21925	COG1984	allophanate hydrolase subunit 2
CAK77_RS21995	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
CAK77_RS22000	COG1802	Transcriptional regulator
CAK77_RS22030	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CAK77_RS22040	COG0473	3-isopropylmalate dehydrogenase activity
CAK77_RS22055	COG1053	succinate dehydrogenase
CAK77_RS22075	COG0640	Transcriptional regulator
CAK77_RS22125	COG2318	DinB family
CAK77_RS22130	COG1960	acyl-CoA dehydrogenase activity
CAK77_RS22155	COG0183	Belongs to the thiolase family
CAK77_RS22160	COG1028	Short-chain dehydrogenase reductase Sdr
CAK77_RS22165	COG2030	dehydratase
CAK77_RS22180	COG0659	secondary active sulfate transmembrane transporter activity
CAK77_RS22185	COG1309	transcriptional regulator
CAK77_RS22190	COG0861	Integral membrane protein TerC family
CAK77_RS22215	COG0318	PFAM AMP-dependent synthetase and ligase
CAK77_RS22230	COG1472	Belongs to the glycosyl hydrolase 3 family
CAK77_RS22235	COG4941	Belongs to the sigma-70 factor family
CAK77_RS22270	COG4981	capsule polysaccharide biosynthetic process
CAK77_RS22310	COG0438	transferase activity, transferring glycosyl groups
CAK77_RS22365	COG2197	response regulator
CAK77_RS22370	COG3850	Histidine kinase
CAK77_RS22390	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
CAK77_RS22420	COG2409	Drug exporters of the RND superfamily
CAK77_RS22485	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CAK77_RS22495	COG2197	response regulator
CAK77_RS22525	COG2353	YceI-like domain
CAK77_RS22540	COG2409	Drug exporters of the RND superfamily
CAK77_RS22555	COG4552	Acetyltransferase involved in intracellular survival and related
CAK77_RS22560	COG1832	CoA-binding protein
CAK77_RS22575	COG3590	peptidase
CAK77_RS22580	COG1376	ErfK ybiS ycfS ynhG family protein
CAK77_RS22585	COG1960	acyl-CoA dehydrogenase activity
CAK77_RS22595	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CAK77_RS22605	COG1937	Protein conserved in bacteria
CAK77_RS22635	COG4122	O-methyltransferase activity
CAK77_RS22650	COG2267	carboxylic ester hydrolase activity
CAK77_RS22680	COG1704	LemA family
CAK77_RS22690	COG0318	PFAM AMP-dependent synthetase and ligase
CAK77_RS22745	COG1024	Enoyl-CoA hydratase
CAK77_RS22750	COG1802	Transcriptional regulator
CAK77_RS22760	COG2267	carboxylic ester hydrolase activity
CAK77_RS22765	COG1309	transcriptional regulator
CAK77_RS22795	COG0435	Glutathione S-transferase
CAK77_RS22835	COG1024	Enoyl-CoA hydratase
CAK77_RS22845	COG2211	Major facilitator Superfamily
CAK77_RS22850	COG2365	Tyrosine phosphatase family
CAK77_RS22915	COG1028	Short-chain dehydrogenase reductase Sdr
CAK77_RS22920	COG1012	belongs to the aldehyde dehydrogenase family
CAK77_RS22935	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CAK77_RS22940	COG1960	acyl-CoA dehydrogenase activity
CAK77_RS22945	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
CAK77_RS22975	COG1396	sequence-specific DNA binding
CAK77_RS22975	COG3800	Transcriptional regulator
CAK77_RS22985	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
CAK77_RS23025	COG0318	PFAM AMP-dependent synthetase and ligase
CAK77_RS23085	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CAK77_RS23095	COG0129	dihydroxy-acid dehydratase activity
CAK77_RS23115	COG2186	Transcriptional regulator
CAK77_RS23145	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CAK77_RS23150	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CAK77_RS23180	COG1028	Short-chain dehydrogenase reductase Sdr
CAK77_RS23220	COG1028	Short-chain dehydrogenase reductase Sdr
CAK77_RS23240	COG0318	PFAM AMP-dependent synthetase and ligase
CAK77_RS23245	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CAK77_RS23250	COG1136	(ABC) transporter
CAK77_RS23260	COG1104	cysteine desulfurase activity
CAK77_RS23325	COG1309	transcriptional regulator
CAK77_RS23335	COG1819	glycosyl
CAK77_RS23380	COG1819	glycosyl
CAK77_RS23485	COG3263	regulation of cellular component size
CAK77_RS23570	COG1595	DNA-templated transcription, initiation
CAK77_RS23580	COG0783	Belongs to the Dps family
CAK77_RS23630	COG1252	NADH dehydrogenase
CAK77_RS23650	COG1937	Protein conserved in bacteria
CAK77_RS23675	COG1403	HNH endonuclease
CAK77_RS23745	COG2140	Oxalate decarboxylase
CAK77_RS23770	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
CAK77_RS23790	COG1376	ErfK ybiS ycfS ynhG family protein
CAK77_RS23815	COG2030	dehydratase
CAK77_RS23820	COG0488	(ABC) transporter
CAK77_RS23825	COG3757	hydrolase, family 25
CAK77_RS23890	COG0583	DNA-binding transcription factor activity
CAK77_RS23900	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CAK77_RS23915	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CAK77_RS23920	COG3757	hydrolase, family 25
CAK77_RS23945	COG2205	protein histidine kinase activity
CAK77_RS23950	COG0745	RESPONSE REGULATOR receiver
CAK77_RS24010	COG1595	DNA-templated transcription, initiation
CAK77_RS24020	COG0667	Aldo Keto reductase
CAK77_RS24040	COG2267	carboxylic ester hydrolase activity
CAK77_RS24045	COG2072	flavoprotein involved in K transport
CAK77_RS24090	COG0629	single-stranded DNA binding
CAK77_RS24105	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CAK77_RS24135	COG1260	myo-inositol-1-phosphate synthase
CAK77_RS24140	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CAK77_RS24145	COG1113	amino acid transport
CAK77_RS24160	COG1309	transcriptional regulator
CAK77_RS24165	COG1028	Short-chain dehydrogenase reductase Sdr
CAK77_RS24180	COG0508	dehydrogenase complex catalyzes the overall conversion of
CAK77_RS24185	COG0022	dehydrogenase e1 component
CAK77_RS24200	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
CAK77_RS24205	COG2311	Membrane
CAK77_RS24275	COG0617	tRNA 3'-terminal CCA addition
CAK77_RS24295	COG1595	DNA-templated transcription, initiation
CAK77_RS24315	COG0860	N-Acetylmuramoyl-L-alanine amidase
CAK77_RS24315	COG3409	Peptidoglycan-binding domain 1 protein
CAK77_RS24325	COG2124	cytochrome p450
CAK77_RS24335	COG1309	transcriptional regulator
CAK77_RS24355	COG1192	Involved in chromosome partitioning
CAK77_RS24360	COG0357	Ribosomal RNA small subunit methyltransferase G
CAK77_RS24370	COG0706	membrane insertase activity
CAK77_RS24375	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CAK77_RS24485	COG2217	Heavy metal translocating P-type atpase
CAK77_RS24495	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family