locus-tag	class	description
EGM63_RS00025	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EGM63_RS00050	COG5002	protein histidine kinase activity
EGM63_RS00070	COG0156	8-amino-7-oxononanoate synthase activity
EGM63_RS00075	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EGM63_RS00085	COG0791	NLP P60 protein
EGM63_RS00085	COG3883	PFAM NLP P60 protein
EGM63_RS00170	COG0300	oxidoreductase activity
EGM63_RS00180	COG2346	COG2346, Truncated hemoglobins
EGM63_RS00200	COG0252	asparaginase activity
EGM63_RS00215	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
EGM63_RS00230	COG2070	2-Nitropropane dioxygenase
EGM63_RS00295	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EGM63_RS00300	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
EGM63_RS00320	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EGM63_RS00355	COG5002	protein histidine kinase activity
EGM63_RS00360	COG0745	RESPONSE REGULATOR receiver
EGM63_RS00410	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
EGM63_RS00430	COG2304	oxidoreductase activity
EGM63_RS00440	COG0714	Associated with various cellular activities
EGM63_RS00450	COG3883	PFAM NLP P60 protein
EGM63_RS00450	COG0791	NLP P60 protein
EGM63_RS00465	COG1309	transcriptional regulator
EGM63_RS00475	COG0488	(ABC) transporter
EGM63_RS00485	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EGM63_RS00490	COG1960	acyl-CoA dehydrogenase activity
EGM63_RS00510	COG2151	metal-sulfur cluster biosynthetic enzyme
EGM63_RS00525	COG0396	ATPase activity
EGM63_RS00575	COG0109	protoheme IX farnesyltransferase activity
EGM63_RS00585	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
EGM63_RS00610	COG0123	including yeast histone deacetylase and acetoin utilization protein
EGM63_RS00615	COG0667	Aldo Keto reductase
EGM63_RS00625	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
EGM63_RS00640	COG0149	triose-phosphate isomerase activity
EGM63_RS00675	COG0318	PFAM AMP-dependent synthetase and ligase
EGM63_RS00680	COG0657	acetylesterase activity
EGM63_RS00720	COG3328	transposase activity
EGM63_RS00735	COG1660	Displays ATPase and GTPase activities
EGM63_RS00740	COG0322	excinuclease ABC activity
EGM63_RS00765	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
EGM63_RS00770	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EGM63_RS00770	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EGM63_RS00805	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EGM63_RS00830	COG0657	acetylesterase activity
EGM63_RS00835	COG2072	flavoprotein involved in K transport
EGM63_RS00840	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
EGM63_RS00850	COG1758	RNA polymerase activity
EGM63_RS00855	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
EGM63_RS00870	COG0284	orotidine-5'-phosphate decarboxylase activity
EGM63_RS00880	COG0505	Belongs to the CarA family
EGM63_RS00900	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
EGM63_RS00910	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EGM63_RS00915	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
EGM63_RS00940	COG2188	Transcriptional regulator
EGM63_RS00955	COG0745	RESPONSE REGULATOR receiver
EGM63_RS00960	COG2205	protein histidine kinase activity
EGM63_RS00990	COG0006	proline dipeptidase activity
EGM63_RS01000	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
EGM63_RS01005	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
EGM63_RS01015	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
EGM63_RS01025	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EGM63_RS01050	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EGM63_RS01055	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EGM63_RS01065	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EGM63_RS01070	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
EGM63_RS01075	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
EGM63_RS01085	COG0432	Pfam Uncharacterised protein family UPF0047
EGM63_RS01160	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
EGM63_RS01180	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EGM63_RS01185	COG0235	Class ii aldolase
EGM63_RS01190	COG1396	sequence-specific DNA binding
EGM63_RS01215	COG1403	HNH endonuclease
EGM63_RS01225	COG0124	histidyl-tRNA synthetase
EGM63_RS01230	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EGM63_RS01245	COG2801	Transposase and inactivated derivatives
EGM63_RS01245	COG3415	Transposase
EGM63_RS01250	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EGM63_RS01255	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EGM63_RS01260	COG0747	negative chemotaxis
EGM63_RS01265	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EGM63_RS01270	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EGM63_RS01285	COG3320	Male sterility
EGM63_RS01285	COG1022	Amp-dependent synthetase and ligase
EGM63_RS01335	COG3766	membrane
EGM63_RS01345	COG0217	transcriptional regulatory protein
EGM63_RS01385	COG0657	acetylesterase activity
EGM63_RS01390	COG2755	lipolytic protein G-D-S-L family
EGM63_RS01405	COG1024	Enoyl-CoA hydratase
EGM63_RS01445	COG0121	glutamine amidotransferase
EGM63_RS01460	COG3391	amine dehydrogenase activity
EGM63_RS01505	COG0745	RESPONSE REGULATOR receiver
EGM63_RS01510	COG2205	protein histidine kinase activity
EGM63_RS01525	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
EGM63_RS01535	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
EGM63_RS01580	COG3956	TIGRFAM MazG family protein
EGM63_RS01605	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EGM63_RS01615	COG1393	Belongs to the ArsC family
EGM63_RS01630	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
EGM63_RS01635	COG0193	aminoacyl-tRNA hydrolase activity
EGM63_RS01640	COG0318	PFAM AMP-dependent synthetase and ligase
EGM63_RS01650	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
EGM63_RS01655	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EGM63_RS01665	COG0084	hydrolase, TatD family'
EGM63_RS01715	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
EGM63_RS01730	COG0297	glycogen (starch) synthase activity
EGM63_RS01770	COG0297	glycogen (starch) synthase activity
EGM63_RS01770	COG0438	transferase activity, transferring glycosyl groups
EGM63_RS01815	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EGM63_RS01850	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EGM63_RS01850	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EGM63_RS01855	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EGM63_RS01860	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
EGM63_RS01875	COG4638	Rieske (2fe-2S)
EGM63_RS01925	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EGM63_RS01930	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
EGM63_RS01945	COG1970	mechanosensitive ion channel activity
EGM63_RS01950	COG0315	cyclic pyranopterin monophosphate synthase activity
EGM63_RS01950	COG0521	Mo-molybdopterin cofactor biosynthetic process
EGM63_RS01955	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EGM63_RS01965	COG2205	protein histidine kinase activity
EGM63_RS01985	COG1960	acyl-CoA dehydrogenase activity
EGM63_RS01990	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EGM63_RS02005	COG1024	Enoyl-CoA hydratase
EGM63_RS02035	COG0138	bifunctional purine biosynthesis protein purh
EGM63_RS02075	COG4942	peptidase
EGM63_RS02095	COG0166	Belongs to the GPI family
EGM63_RS02105	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
EGM63_RS02140	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
EGM63_RS02160	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EGM63_RS02165	COG0246	Mannitol dehydrogenase
EGM63_RS02215	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EGM63_RS02315	COG3415	Transposase
EGM63_RS02315	COG2801	Transposase and inactivated derivatives
EGM63_RS02320	COG3328	transposase activity
EGM63_RS02390	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EGM63_RS02400	COG0438	transferase activity, transferring glycosyl groups
EGM63_RS02410	COG0745	RESPONSE REGULATOR receiver
EGM63_RS02420	COG3547	Transposase (IS116 IS110 IS902 family)
EGM63_RS02440	COG0259	pyridoxamine-phosphate oxidase activity
EGM63_RS02465	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
EGM63_RS02505	COG2814	Major facilitator Superfamily
EGM63_RS02520	COG0435	Glutathione S-transferase
EGM63_RS02530	COG1278	Cold shock
EGM63_RS02535	COG3304	Inner membrane component domain
EGM63_RS02560	COG0521	Mo-molybdopterin cofactor biosynthetic process
EGM63_RS02580	COG1061	Type III restriction enzyme res subunit
EGM63_RS02585	COG0183	Belongs to the thiolase family
EGM63_RS02600	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EGM63_RS02625	COG1250	3-hydroxyacyl-CoA dehydrogenase
EGM63_RS02625	COG1024	Enoyl-CoA hydratase
EGM63_RS02630	COG0183	Belongs to the thiolase family
EGM63_RS02650	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EGM63_RS02660	COG3961	Belongs to the TPP enzyme family
EGM63_RS02675	COG0318	PFAM AMP-dependent synthetase and ligase
EGM63_RS02690	COG1024	Enoyl-CoA hydratase
EGM63_RS02700	COG1309	transcriptional regulator
EGM63_RS02730	COG1309	transcriptional regulator
EGM63_RS02760	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EGM63_RS02785	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EGM63_RS02790	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EGM63_RS02795	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EGM63_RS02840	COG1960	acyl-CoA dehydrogenase activity
EGM63_RS02845	COG1960	acyl-CoA dehydrogenase activity
EGM63_RS02850	COG0778	Nitroreductase
EGM63_RS02850	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
EGM63_RS02890	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
EGM63_RS02935	COG2124	cytochrome p450
EGM63_RS02955	COG2124	cytochrome p450
EGM63_RS02965	COG1309	transcriptional regulator
EGM63_RS02970	COG0183	Belongs to the thiolase family
EGM63_RS02990	COG4638	Rieske (2fe-2S)
EGM63_RS03000	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
EGM63_RS03010	COG1960	acyl-CoA dehydrogenase activity
EGM63_RS03025	COG1960	acyl-CoA dehydrogenase activity
EGM63_RS03035	COG1028	Short-chain dehydrogenase reductase Sdr
EGM63_RS03045	COG1028	Short-chain dehydrogenase reductase Sdr
EGM63_RS03050	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EGM63_RS03090	COG2132	Multicopper oxidase
EGM63_RS03105	COG1028	Short-chain dehydrogenase reductase Sdr
EGM63_RS03115	COG1053	succinate dehydrogenase
EGM63_RS03120	COG3384	dioxygenase
EGM63_RS03125	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EGM63_RS03130	COG2267	carboxylic ester hydrolase activity
EGM63_RS03140	COG1053	succinate dehydrogenase
EGM63_RS03145	COG4585	Histidine kinase
EGM63_RS03155	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EGM63_RS03165	COG0183	Belongs to the thiolase family
EGM63_RS03170	COG3479	Phenolic acid decarboxylase
EGM63_RS03175	COG0596	Alpha beta hydrolase
EGM63_RS03185	COG1960	acyl-CoA dehydrogenase activity
EGM63_RS03190	COG1960	acyl-CoA dehydrogenase activity
EGM63_RS03200	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EGM63_RS03215	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EGM63_RS03220	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EGM63_RS03225	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EGM63_RS03230	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EGM63_RS03230	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EGM63_RS03260	COG2124	cytochrome p450
EGM63_RS03275	COG1028	Short-chain dehydrogenase reductase Sdr
EGM63_RS03300	COG2801	Transposase and inactivated derivatives
EGM63_RS03300	COG3415	Transposase
EGM63_RS03305	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
EGM63_RS03310	COG0590	tRNA wobble adenosine to inosine editing
EGM63_RS03315	COG0640	Transcriptional regulator
EGM63_RS03365	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EGM63_RS03390	COG0745	RESPONSE REGULATOR receiver
EGM63_RS03400	COG3118	belongs to the thioredoxin family
EGM63_RS03420	COG4044	May play a role in the intracellular transport of hydrophobic ligands
EGM63_RS03430	COG0404	The glycine cleavage system catalyzes the degradation of glycine
EGM63_RS03440	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
EGM63_RS03460	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EGM63_RS03480	COG2837	iron assimilation
EGM63_RS03505	COG0047	phosphoribosylformylglycinamidine synthase activity
EGM63_RS03510	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EGM63_RS03520	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
EGM63_RS03535	COG0477	Major facilitator Superfamily
EGM63_RS03540	COG0477	Major facilitator Superfamily
EGM63_RS03560	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
EGM63_RS03575	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
EGM63_RS03635	COG4221	oxidoreductase activity
EGM63_RS03640	COG2124	cytochrome p450
EGM63_RS03670	COG2205	protein histidine kinase activity
EGM63_RS03675	COG0745	RESPONSE REGULATOR receiver
EGM63_RS03690	COG3415	Transposase
EGM63_RS03690	COG2801	Transposase and inactivated derivatives
EGM63_RS03730	COG0154	amidase activity
EGM63_RS03740	COG1316	TRANSCRIPTIONal
EGM63_RS03755	COG1024	Enoyl-CoA hydratase
EGM63_RS03760	COG0390	transport system, permease component
EGM63_RS03765	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EGM63_RS03775	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
EGM63_RS03800	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EGM63_RS03825	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EGM63_RS03835	COG1028	Short-chain dehydrogenase reductase Sdr
EGM63_RS03845	COG1960	acyl-CoA dehydrogenase activity
EGM63_RS03855	COG0318	PFAM AMP-dependent synthetase and ligase
EGM63_RS03880	COG3001	Fructosamine kinase
EGM63_RS03890	COG1024	Enoyl-CoA hydratase
EGM63_RS03900	COG2124	cytochrome p450
EGM63_RS03910	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EGM63_RS03925	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
EGM63_RS03940	COG4638	Rieske (2fe-2S)
EGM63_RS03970	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EGM63_RS03975	COG4569	acetaldehyde dehydrogenase (acetylating) activity
EGM63_RS03980	COG3971	2-oxopent-4-enoate hydratase activity
EGM63_RS03985	COG1053	succinate dehydrogenase
EGM63_RS03990	COG2030	dehydratase
EGM63_RS04010	COG2030	dehydratase
EGM63_RS04015	COG1960	acyl-CoA dehydrogenase activity
EGM63_RS04020	COG1960	acyl-CoA dehydrogenase activity
EGM63_RS04025	COG2124	cytochrome p450
EGM63_RS04030	COG0183	Belongs to the thiolase family
EGM63_RS04045	COG1028	Short-chain dehydrogenase reductase Sdr
EGM63_RS04050	COG1028	Short-chain dehydrogenase reductase Sdr
EGM63_RS04055	COG1024	Enoyl-CoA hydratase
EGM63_RS04085	COG0183	Belongs to the thiolase family
EGM63_RS04095	COG1028	Short-chain dehydrogenase reductase Sdr
EGM63_RS04100	COG1960	acyl-CoA dehydrogenase activity
EGM63_RS04110	COG1960	acyl-CoA dehydrogenase activity
EGM63_RS04115	COG1960	acyl-CoA dehydrogenase activity
EGM63_RS04120	COG1960	acyl-CoA dehydrogenase activity
EGM63_RS04125	COG0436	Aminotransferase
EGM63_RS04175	COG1960	acyl-CoA dehydrogenase activity
EGM63_RS04180	COG1309	transcriptional regulator
EGM63_RS04185	COG1609	Transcriptional regulator
EGM63_RS04195	COG1121	(ABC) transporter
EGM63_RS04200	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EGM63_RS04205	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
EGM63_RS04225	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EGM63_RS04235	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EGM63_RS04240	COG0215	cysteine-tRNA ligase activity
EGM63_RS04250	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
EGM63_RS04270	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
EGM63_RS04350	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
EGM63_RS04380	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EGM63_RS04385	COG0302	gtp cyclohydrolase
EGM63_RS04390	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EGM63_RS04405	COG2267	carboxylic ester hydrolase activity
EGM63_RS04415	COG1063	alcohol dehydrogenase
EGM63_RS04430	COG3391	amine dehydrogenase activity
EGM63_RS04445	COG0037	tRNA processing
EGM63_RS04455	COG2027	D-alanyl-D-alanine carboxypeptidase
EGM63_RS04475	COG1215	transferase activity, transferring glycosyl groups
EGM63_RS04495	COG2801	Transposase and inactivated derivatives
EGM63_RS04495	COG3415	Transposase
EGM63_RS04505	COG0470	DNA polymerase III
EGM63_RS04530	COG1111	helicase
EGM63_RS04530	COG1205	dead DEAH box helicase
EGM63_RS04595	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EGM63_RS04600	COG0601	transmembrane transport
EGM63_RS04615	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EGM63_RS04650	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EGM63_RS04665	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EGM63_RS04700	COG1408	metallophosphoesterase
EGM63_RS04705	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EGM63_RS04765	COG1366	Belongs to the anti-sigma-factor antagonist family
EGM63_RS04770	COG1366	Belongs to the anti-sigma-factor antagonist family
EGM63_RS04775	COG2172	sigma factor antagonist activity
EGM63_RS04805	COG2890	protein-(glutamine-N5) methyltransferase activity
EGM63_RS04810	COG0693	protein deglycase activity
EGM63_RS04815	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EGM63_RS04825	COG0437	4 iron, 4 sulfur cluster binding
EGM63_RS04830	COG0243	molybdopterin cofactor binding
EGM63_RS04830	COG3383	formate dehydrogenase (NAD+) activity
EGM63_RS04835	COG3383	formate dehydrogenase (NAD+) activity
EGM63_RS04835	COG0243	molybdopterin cofactor binding
EGM63_RS04840	COG0709	Synthesizes selenophosphate from selenide and ATP
EGM63_RS04880	COG0714	Associated with various cellular activities
EGM63_RS04905	COG1695	Transcriptional regulator
EGM63_RS04910	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
EGM63_RS04920	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EGM63_RS04940	COG3804	dihydrodipicolinate reductase
EGM63_RS04960	COG0596	Alpha beta hydrolase
EGM63_RS04965	COG2124	cytochrome p450
EGM63_RS04980	COG1793	dna ligase
EGM63_RS05025	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
EGM63_RS05080	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EGM63_RS05090	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EGM63_RS05105	COG0860	N-Acetylmuramoyl-L-alanine amidase
EGM63_RS05110	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
EGM63_RS05125	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
EGM63_RS05140	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EGM63_RS05190	COG0121	glutamine amidotransferase
EGM63_RS05200	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EGM63_RS05220	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EGM63_RS05225	COG3800	Transcriptional regulator
EGM63_RS05225	COG1396	sequence-specific DNA binding
EGM63_RS05235	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
EGM63_RS05250	COG2301	Belongs to the HpcH HpaI aldolase family
EGM63_RS05255	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EGM63_RS05330	COG0590	tRNA wobble adenosine to inosine editing
EGM63_RS05340	COG0287	Prephenate dehydrogenase
EGM63_RS05355	COG1174	glycine betaine transport
EGM63_RS05370	COG5416	Lipopolysaccharide assembly protein A domain
EGM63_RS05415	COG2015	COG2015, Alkyl sulfatase and related hydrolases
EGM63_RS05425	COG2205	protein histidine kinase activity
EGM63_RS05435	COG0745	RESPONSE REGULATOR receiver
EGM63_RS05450	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
EGM63_RS05465	COG3415	Transposase
EGM63_RS05465	COG2801	Transposase and inactivated derivatives
EGM63_RS05480	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EGM63_RS05500	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EGM63_RS05520	COG0604	alcohol dehydrogenase
EGM63_RS05570	COG0277	FAD linked oxidase domain protein
EGM63_RS05575	COG1028	Short-chain dehydrogenase reductase Sdr
EGM63_RS05630	COG1960	acyl-CoA dehydrogenase activity
EGM63_RS05645	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EGM63_RS05650	COG3321	synthase
EGM63_RS05650	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
EGM63_RS05650	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EGM63_RS05655	COG0318	PFAM AMP-dependent synthetase and ligase
EGM63_RS05660	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
EGM63_RS05665	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
EGM63_RS05675	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
EGM63_RS05690	COG1216	Glycosyl transferase, family 2
EGM63_RS05710	COG0561	phosphatase activity
EGM63_RS05765	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
EGM63_RS05800	COG1316	TRANSCRIPTIONal
EGM63_RS05850	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EGM63_RS05855	COG2072	flavoprotein involved in K transport
EGM63_RS05860	COG1309	transcriptional regulator
EGM63_RS05865	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EGM63_RS05870	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
EGM63_RS05870	COG1796	DNA polymerase
EGM63_RS05890	COG0070	glutamate synthase
EGM63_RS05890	COG0069	glutamate synthase activity
EGM63_RS05890	COG0067	glutamate synthase
EGM63_RS05925	COG1404	Belongs to the peptidase S8 family
EGM63_RS05980	COG1309	transcriptional regulator
EGM63_RS05985	COG1024	Enoyl-CoA hydratase
EGM63_RS06000	COG1960	acyl-CoA dehydrogenase activity
EGM63_RS06015	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EGM63_RS06020	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EGM63_RS06025	COG1116	anion transmembrane transporter activity
EGM63_RS06040	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EGM63_RS06065	COG0346	lactoylglutathione lyase activity
EGM63_RS06070	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EGM63_RS06080	COG0477	Major facilitator Superfamily
EGM63_RS06100	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EGM63_RS06105	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EGM63_RS06110	COG0659	secondary active sulfate transmembrane transporter activity
EGM63_RS06160	COG1309	transcriptional regulator
EGM63_RS06210	COG4974	Belongs to the 'phage' integrase family
EGM63_RS06225	COG3328	transposase activity
EGM63_RS06280	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EGM63_RS06290	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EGM63_RS06310	COG1247	-acetyltransferase
EGM63_RS06350	COG0277	FAD linked oxidase domain protein
EGM63_RS06360	COG1028	Short-chain dehydrogenase reductase Sdr
EGM63_RS06390	COG1309	transcriptional regulator
EGM63_RS06400	COG0204	Acyl-transferase
EGM63_RS06410	COG0359	binds to the 23S rRNA
EGM63_RS06425	COG0360	Binds together with S18 to 16S ribosomal RNA
EGM63_RS06440	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EGM63_RS06485	COG0596	Alpha beta hydrolase
EGM63_RS06485	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EGM63_RS06500	COG0765	amino acid transport
EGM63_RS06520	COG0495	leucyl-tRNA aminoacylation
EGM63_RS06580	COG0741	lytic transglycosylase activity
EGM63_RS06580	COG0791	NLP P60 protein
EGM63_RS06605	COG1960	acyl-CoA dehydrogenase activity
EGM63_RS06640	COG3328	transposase activity
EGM63_RS06680	COG1716	ATPase activity
EGM63_RS06705	COG0515	serine threonine protein kinase
EGM63_RS06755	COG3328	transposase activity
EGM63_RS06770	COG1819	glycosyl
EGM63_RS06780	COG1028	Short-chain dehydrogenase reductase Sdr
EGM63_RS06780	COG0604	alcohol dehydrogenase
EGM63_RS06780	COG3321	synthase
EGM63_RS06790	COG0701	Predicted permease
EGM63_RS06800	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
EGM63_RS06805	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
EGM63_RS06810	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EGM63_RS06825	COG0254	rRNA binding
EGM63_RS06835	COG0523	cobalamin synthesis protein
EGM63_RS06845	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EGM63_RS06850	COG1121	(ABC) transporter
EGM63_RS06855	COG0803	Belongs to the bacterial solute-binding protein 9 family
EGM63_RS06910	COG1404	Belongs to the peptidase S8 family
EGM63_RS06930	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
EGM63_RS06935	COG0778	Nitroreductase
EGM63_RS06965	COG1309	transcriptional regulator
EGM63_RS06995	COG2130	NADP-dependent
EGM63_RS07030	COG0246	Mannitol dehydrogenase
EGM63_RS07050	COG1376	ErfK ybiS ycfS ynhG family protein
EGM63_RS07090	COG2124	cytochrome p450
EGM63_RS07105	COG0717	Belongs to the dCTP deaminase family
EGM63_RS07130	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
EGM63_RS07160	COG0247	lactate metabolic process
EGM63_RS07160	COG2181	nitrate reductase activity
EGM63_RS07175	COG2814	Major facilitator Superfamily
EGM63_RS07185	COG1511	domain protein
EGM63_RS07205	COG0443	Heat shock 70 kDa protein
EGM63_RS07210	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
EGM63_RS07215	COG0484	heat shock protein binding
EGM63_RS07220	COG0789	Transcriptional regulator
EGM63_RS07280	COG0542	response to heat
EGM63_RS07285	COG2826	transposase and inactivated derivatives, IS30 family
EGM63_RS07345	COG1994	Peptidase M50
EGM63_RS07355	COG0406	alpha-ribazole phosphatase activity
EGM63_RS07360	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
EGM63_RS07375	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EGM63_RS07385	COG1252	NADH dehydrogenase
EGM63_RS07410	COG1960	acyl-CoA dehydrogenase activity
EGM63_RS07415	COG1960	acyl-CoA dehydrogenase activity
EGM63_RS07420	COG1028	Short-chain dehydrogenase reductase Sdr
EGM63_RS07430	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
EGM63_RS07440	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EGM63_RS07455	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
EGM63_RS07480	COG1309	transcriptional regulator
EGM63_RS07495	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EGM63_RS07510	COG0352	thiamine-phosphate diphosphorylase activity
EGM63_RS07515	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EGM63_RS07515	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
EGM63_RS07525	COG2022	thiamine diphosphate biosynthetic process
EGM63_RS07555	COG2234	aminopeptidase activity
EGM63_RS07560	COG2234	aminopeptidase activity
EGM63_RS07570	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EGM63_RS07590	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
EGM63_RS07620	COG0242	peptide deformylase activity
EGM63_RS07635	COG2032	superoxide dismutase activity
EGM63_RS07670	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EGM63_RS07680	COG0688	phosphatidylethanolamine metabolic process
EGM63_RS07685	COG0738	Major facilitator superfamily
EGM63_RS07695	COG4221	oxidoreductase activity
EGM63_RS07710	COG0459	protein refolding
EGM63_RS07775	COG1024	Enoyl-CoA hydratase
EGM63_RS07785	COG1505	serine-type exopeptidase activity
EGM63_RS07845	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EGM63_RS07860	COG2733	membrane
EGM63_RS07890	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
EGM63_RS07910	COG0812	UDP-N-acetylmuramate dehydrogenase activity
EGM63_RS07935	COG0438	transferase activity, transferring glycosyl groups
EGM63_RS07945	COG0588	phosphoglycerate mutase activity
EGM63_RS08025	COG2030	dehydratase
EGM63_RS08080	COG0181	hydroxymethylbilane synthase activity
EGM63_RS08105	COG1366	Belongs to the anti-sigma-factor antagonist family
EGM63_RS08115	COG2755	lipolytic protein G-D-S-L family
EGM63_RS08120	COG2755	lipolytic protein G-D-S-L family
EGM63_RS08120	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
EGM63_RS08150	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EGM63_RS08155	COG4948	Mandelate Racemase Muconate Lactonizing
EGM63_RS08170	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EGM63_RS08175	COG0406	alpha-ribazole phosphatase activity
EGM63_RS08185	COG0785	Cytochrome C biogenesis protein
EGM63_RS08195	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EGM63_RS08200	COG2894	cell division
EGM63_RS08215	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EGM63_RS08225	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
EGM63_RS08230	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EGM63_RS08275	COG0306	phosphate transporter
EGM63_RS08285	COG4221	oxidoreductase activity
EGM63_RS08300	COG0667	Aldo Keto reductase
EGM63_RS08310	COG0318	PFAM AMP-dependent synthetase and ligase
EGM63_RS08315	COG1228	amidohydrolase
EGM63_RS08320	COG4948	Mandelate Racemase Muconate Lactonizing
EGM63_RS08350	COG2226	methyltransferase
EGM63_RS08365	COG0142	geranyltranstransferase activity
EGM63_RS08380	COG0659	secondary active sulfate transmembrane transporter activity
EGM63_RS08385	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
EGM63_RS08390	COG2072	flavoprotein involved in K transport
EGM63_RS08395	COG1666	GTP binding
EGM63_RS08410	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
EGM63_RS08415	COG1914	H( )-stimulated, divalent metal cation uptake system
EGM63_RS08435	COG2124	cytochrome p450
EGM63_RS08460	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
EGM63_RS08480	COG3537	Alpha-1,2-mannosidase
EGM63_RS08490	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
EGM63_RS08520	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EGM63_RS08525	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EGM63_RS08550	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EGM63_RS08565	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EGM63_RS08575	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
EGM63_RS08580	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EGM63_RS08600	COG1752	Esterase of the alpha-beta hydrolase superfamily
EGM63_RS08610	COG0243	molybdopterin cofactor binding
EGM63_RS08625	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EGM63_RS08650	COG2030	dehydratase
EGM63_RS08655	COG2030	dehydratase
EGM63_RS08660	COG2030	dehydratase
EGM63_RS08670	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EGM63_RS08690	COG4941	Belongs to the sigma-70 factor family
EGM63_RS08700	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EGM63_RS08705	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EGM63_RS08710	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EGM63_RS08720	COG2318	DinB family
EGM63_RS08750	COG0222	ribosome binding
EGM63_RS08775	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EGM63_RS08785	COG1960	acyl-CoA dehydrogenase activity
EGM63_RS08815	COG1309	transcriptional regulator
EGM63_RS08850	COG1028	Short-chain dehydrogenase reductase Sdr
EGM63_RS08860	COG0483	inositol monophosphate 1-phosphatase activity
EGM63_RS08865	COG0656	L-ascorbic acid biosynthetic process
EGM63_RS08885	COG0535	radical SAM domain protein
EGM63_RS08930	COG0088	Forms part of the polypeptide exit tunnel
EGM63_RS08940	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
EGM63_RS08955	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
EGM63_RS08970	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
EGM63_RS08990	COG1262	PFAM Formylglycine-generating sulfatase enzyme
EGM63_RS09015	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
EGM63_RS09035	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
EGM63_RS09040	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
EGM63_RS09055	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EGM63_RS09060	COG0616	signal peptide processing
EGM63_RS09065	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
EGM63_RS09070	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
EGM63_RS09075	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
EGM63_RS09085	COG1063	alcohol dehydrogenase
EGM63_RS09095	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EGM63_RS09110	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
EGM63_RS09120	COG0563	adenylate kinase activity
EGM63_RS09140	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EGM63_RS09155	COG0577	efflux transmembrane transporter activity
EGM63_RS09160	COG1136	(ABC) transporter
EGM63_RS09160	COG0577	efflux transmembrane transporter activity
EGM63_RS09175	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EGM63_RS09180	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EGM63_RS09195	COG1960	acyl-CoA dehydrogenase activity
EGM63_RS09220	COG3794	PFAM blue (type 1) copper domain protein
EGM63_RS09270	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
EGM63_RS09275	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EGM63_RS09300	COG0203	ribosomal protein L17
EGM63_RS09305	COG0101	tRNA pseudouridine synthase activity
EGM63_RS09325	COG1404	Belongs to the peptidase S8 family
EGM63_RS09335	COG1674	ftsk spoiiie
EGM63_RS09345	COG4842	Belongs to the WXG100 family
EGM63_RS09350	COG4842	Belongs to the WXG100 family
EGM63_RS09360	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
EGM63_RS09365	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EGM63_RS09380	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EGM63_RS09395	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EGM63_RS09415	COG0076	glutamate decarboxylase activity
EGM63_RS09440	COG0456	acetyltransferase
EGM63_RS09455	COG0459	protein refolding
EGM63_RS09470	COG1396	sequence-specific DNA binding
EGM63_RS09475	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
EGM63_RS09490	COG2032	superoxide dismutase activity
EGM63_RS09540	COG1028	Short-chain dehydrogenase reductase Sdr
EGM63_RS09585	COG1309	transcriptional regulator
EGM63_RS09595	COG1028	Short-chain dehydrogenase reductase Sdr
EGM63_RS09600	COG0318	PFAM AMP-dependent synthetase and ligase
EGM63_RS09625	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EGM63_RS09635	COG1609	Transcriptional regulator
EGM63_RS09655	COG1309	transcriptional regulator
EGM63_RS09675	COG3588	fructose-bisphosphate aldolase
EGM63_RS09705	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
EGM63_RS09710	COG4638	Rieske (2fe-2S)
EGM63_RS09720	COG2197	response regulator
EGM63_RS09725	COG4585	Histidine kinase
EGM63_RS09740	COG1674	ftsk spoiiie
EGM63_RS09835	COG1595	DNA-templated transcription, initiation
EGM63_RS09855	COG0860	N-Acetylmuramoyl-L-alanine amidase
EGM63_RS09855	COG3409	Peptidoglycan-binding domain 1 protein
EGM63_RS09870	COG1192	Involved in chromosome partitioning
EGM63_RS09875	COG0357	Ribosomal RNA small subunit methyltransferase G
EGM63_RS09885	COG0706	membrane insertase activity
EGM63_RS09890	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
EGM63_RS09895	COG0594	ribonuclease P activity
EGM63_RS09905	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EGM63_RS09910	COG0592	DNA-directed DNA polymerase activity
EGM63_RS09915	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EGM63_RS09920	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
EGM63_RS09925	COG0187	DNA topoisomerase II activity
EGM63_RS09950	COG3415	Transposase
EGM63_RS09950	COG2801	Transposase and inactivated derivatives
EGM63_RS09955	COG3328	transposase activity
EGM63_RS09990	COG0318	PFAM AMP-dependent synthetase and ligase
EGM63_RS10010	COG3547	Transposase (IS116 IS110 IS902 family)
EGM63_RS10020	COG1937	Protein conserved in bacteria
EGM63_RS10035	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
EGM63_RS10040	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EGM63_RS10040	COG2226	methyltransferase
EGM63_RS10040	COG3433	isochorismatase activity
EGM63_RS10045	COG2226	methyltransferase
EGM63_RS10045	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EGM63_RS10045	COG3433	isochorismatase activity
EGM63_RS10050	COG0477	Major facilitator Superfamily
EGM63_RS10070	COG2375	cellular response to nickel ion
EGM63_RS10070	COG1132	(ABC) transporter
EGM63_RS10090	COG1129	ABC transporter
EGM63_RS10110	COG1120	ATPase activity
EGM63_RS10115	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EGM63_RS10155	COG0346	lactoylglutathione lyase activity
EGM63_RS10170	COG1960	acyl-CoA dehydrogenase activity
EGM63_RS10185	COG0318	PFAM AMP-dependent synthetase and ligase
EGM63_RS10195	COG2223	nitrite transmembrane transporter activity
EGM63_RS10200	COG1309	transcriptional regulator
EGM63_RS10210	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
EGM63_RS10215	COG1984	allophanate hydrolase subunit 2
EGM63_RS10250	COG2146	nitrite reductase [NAD(P)H] activity
EGM63_RS10250	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EGM63_RS10270	COG1053	succinate dehydrogenase
EGM63_RS10290	COG1960	acyl-CoA dehydrogenase activity
EGM63_RS10295	COG0183	Belongs to the thiolase family
EGM63_RS10300	COG1028	Short-chain dehydrogenase reductase Sdr
EGM63_RS10305	COG2030	dehydratase
EGM63_RS10320	COG1472	Belongs to the glycosyl hydrolase 3 family
EGM63_RS10335	COG4981	capsule polysaccharide biosynthetic process
EGM63_RS10385	COG0583	DNA-binding transcription factor activity
EGM63_RS10390	COG0028	Belongs to the TPP enzyme family
EGM63_RS10395	COG1012	belongs to the aldehyde dehydrogenase family
EGM63_RS10400	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EGM63_RS10410	COG3415	Transposase
EGM63_RS10410	COG2801	Transposase and inactivated derivatives
EGM63_RS10445	COG0500	methyltransferase
EGM63_RS10455	COG1309	transcriptional regulator
EGM63_RS10470	COG1024	Enoyl-CoA hydratase
EGM63_RS10480	COG0657	acetylesterase activity
EGM63_RS10485	COG0657	acetylesterase activity
EGM63_RS10515	COG1024	Enoyl-CoA hydratase
EGM63_RS10530	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
EGM63_RS10545	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EGM63_RS10555	COG2409	Drug exporters of the RND superfamily
EGM63_RS10580	COG0243	molybdopterin cofactor binding
EGM63_RS10590	COG1376	ErfK ybiS ycfS ynhG family protein
EGM63_RS10595	COG2814	Major facilitator Superfamily
EGM63_RS10600	COG1937	Protein conserved in bacteria
EGM63_RS10605	COG0129	dihydroxy-acid dehydratase activity
EGM63_RS10620	COG4122	O-methyltransferase activity
EGM63_RS10630	COG1472	Belongs to the glycosyl hydrolase 3 family
EGM63_RS10645	COG2267	carboxylic ester hydrolase activity
EGM63_RS10685	COG3619	membrane
EGM63_RS10700	COG1714	RDD family
EGM63_RS10715	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EGM63_RS10740	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EGM63_RS10745	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EGM63_RS10775	COG0657	acetylesterase activity
EGM63_RS10780	COG2072	flavoprotein involved in K transport
EGM63_RS10800	COG2124	cytochrome p450
EGM63_RS10825	COG1960	acyl-CoA dehydrogenase activity
EGM63_RS10875	COG1309	transcriptional regulator
EGM63_RS10915	COG1028	Short-chain dehydrogenase reductase Sdr
EGM63_RS10920	COG1012	belongs to the aldehyde dehydrogenase family
EGM63_RS10935	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
EGM63_RS10945	COG1741	Belongs to the pirin family
EGM63_RS10950	COG0783	Belongs to the Dps family
EGM63_RS10980	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EGM63_RS11045	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EGM63_RS11065	COG2267	carboxylic ester hydrolase activity
EGM63_RS11075	COG1937	Protein conserved in bacteria
EGM63_RS11090	COG0842	Transport permease protein
EGM63_RS11090	COG1129	ABC transporter
EGM63_RS11110	COG3281	Trehalose synthase
EGM63_RS11120	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EGM63_RS11140	COG0028	Belongs to the TPP enzyme family
EGM63_RS11145	COG0583	DNA-binding transcription factor activity
EGM63_RS11155	COG1376	ErfK ybiS ycfS ynhG family protein
EGM63_RS11165	COG3321	synthase
EGM63_RS11165	COG0604	alcohol dehydrogenase
EGM63_RS11185	COG2755	lipolytic protein G-D-S-L family
EGM63_RS11185	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
EGM63_RS11200	COG0028	Belongs to the TPP enzyme family
EGM63_RS11210	COG1028	Short-chain dehydrogenase reductase Sdr
EGM63_RS11215	COG2072	flavoprotein involved in K transport
EGM63_RS11225	COG1028	Short-chain dehydrogenase reductase Sdr
EGM63_RS11240	COG0318	PFAM AMP-dependent synthetase and ligase
EGM63_RS11245	COG1028	Short-chain dehydrogenase reductase Sdr
EGM63_RS11280	COG0318	PFAM AMP-dependent synthetase and ligase
EGM63_RS11320	COG5651	PPE family
EGM63_RS11325	COG0519	Catalyzes the synthesis of GMP from XMP
EGM63_RS11325	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EGM63_RS11365	COG0406	alpha-ribazole phosphatase activity
EGM63_RS11380	COG2030	dehydratase
EGM63_RS11385	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EGM63_RS11385	COG1877	trehalose-phosphatase activity
EGM63_RS11395	COG0587	DNA-directed DNA polymerase activity
EGM63_RS11405	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
EGM63_RS11415	COG5002	protein histidine kinase activity
EGM63_RS11420	COG2018	Roadblock/LC7 domain
EGM63_RS11435	COG1357	PFAM Pentapeptide repeats (8 copies)
EGM63_RS11445	COG0842	Transport permease protein
EGM63_RS11445	COG1716	ATPase activity
EGM63_RS11445	COG1131	(ABC) transporter
EGM63_RS11450	COG1131	(ABC) transporter
EGM63_RS11450	COG0842	Transport permease protein
EGM63_RS11450	COG1716	ATPase activity
EGM63_RS11460	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EGM63_RS11485	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EGM63_RS11490	COG2873	o-acetylhomoserine
EGM63_RS11510	COG0180	Tryptophanyl-tRNA synthetase
EGM63_RS11515	COG1295	ribonuclease BN
EGM63_RS11525	COG0402	S-adenosylhomocysteine deaminase activity
EGM63_RS11530	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
EGM63_RS11535	COG2814	Major facilitator Superfamily
EGM63_RS11540	COG1686	Belongs to the peptidase S11 family
EGM63_RS11550	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EGM63_RS11555	COG1595	DNA-templated transcription, initiation
EGM63_RS11565	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EGM63_RS11580	COG2009	succinate dehydrogenase
EGM63_RS11610	COG2304	oxidoreductase activity
EGM63_RS11615	COG2304	oxidoreductase activity
EGM63_RS11625	COG3511	phospholipase C
EGM63_RS11630	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
EGM63_RS11635	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EGM63_RS11650	COG1473	amidohydrolase
EGM63_RS11655	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
EGM63_RS11655	COG1473	amidohydrolase
EGM63_RS11670	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
EGM63_RS11675	COG0564	pseudouridine synthase activity
EGM63_RS11725	COG1309	transcriptional regulator
EGM63_RS11730	COG1012	belongs to the aldehyde dehydrogenase family
EGM63_RS11740	COG1522	sequence-specific DNA binding
EGM63_RS11770	COG1366	Belongs to the anti-sigma-factor antagonist family
EGM63_RS11775	COG4770	biotin carboxylase activity
EGM63_RS11790	COG0424	maF-like protein
EGM63_RS11800	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EGM63_RS11845	COG4251	negative regulation of phosphorylation
EGM63_RS11850	COG0784	Response regulator, receiver
EGM63_RS11865	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EGM63_RS11870	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
EGM63_RS11890	COG1316	TRANSCRIPTIONal
EGM63_RS11905	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
EGM63_RS11920	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
EGM63_RS11920	COG0778	Nitroreductase
EGM63_RS11950	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EGM63_RS11960	COG1482	cell wall glycoprotein biosynthetic process
EGM63_RS11965	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EGM63_RS11970	COG0531	amino acid
EGM63_RS11975	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EGM63_RS11995	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
EGM63_RS12010	COG5000	phosphorelay sensor kinase activity
EGM63_RS12010	COG5002	protein histidine kinase activity
EGM63_RS12015	COG5401	PFAM Sporulation and spore germination
EGM63_RS12030	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
EGM63_RS12035	COG0653	protein targeting
EGM63_RS12045	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
EGM63_RS12050	COG2020	methyltransferase activity
EGM63_RS12075	COG2326	polyphosphate kinase activity
EGM63_RS12125	COG0183	Belongs to the thiolase family
EGM63_RS12130	COG1733	regulation of RNA biosynthetic process
EGM63_RS12135	COG1162	GTPase activity
EGM63_RS12140	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
EGM63_RS12150	COG1403	HNH endonuclease
EGM63_RS12165	COG1028	Short-chain dehydrogenase reductase Sdr
EGM63_RS12175	COG1028	Short-chain dehydrogenase reductase Sdr
EGM63_RS12185	COG1063	alcohol dehydrogenase
EGM63_RS12210	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
EGM63_RS12245	COG0406	alpha-ribazole phosphatase activity
EGM63_RS12260	COG0513	Belongs to the DEAD box helicase family
EGM63_RS12305	COG0596	Alpha beta hydrolase
EGM63_RS12320	COG0210	DNA helicase
EGM63_RS12350	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
EGM63_RS12365	COG3480	Lon protease (S16) C-terminal proteolytic domain
EGM63_RS12455	COG2197	response regulator
EGM63_RS12460	COG4585	Histidine kinase
EGM63_RS12485	COG3707	response regulator
EGM63_RS12495	COG0789	Transcriptional regulator
EGM63_RS12555	COG1573	uracil-dna glycosylase
EGM63_RS12560	COG0028	Belongs to the TPP enzyme family
EGM63_RS12575	COG1028	Short-chain dehydrogenase reductase Sdr
EGM63_RS12580	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
EGM63_RS12580	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
EGM63_RS12585	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
EGM63_RS12595	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EGM63_RS12600	COG2192	nodulation
EGM63_RS12605	COG1088	dTDP-glucose 4,6-dehydratase activity
EGM63_RS12615	COG0297	glycogen (starch) synthase activity
EGM63_RS12655	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EGM63_RS12680	COG2201	protein-glutamate methylesterase activity
EGM63_RS12695	COG2201	protein-glutamate methylesterase activity
EGM63_RS12720	COG0477	Major facilitator Superfamily
EGM63_RS12770	COG0714	Associated with various cellular activities
EGM63_RS12785	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
EGM63_RS12790	COG1309	transcriptional regulator
EGM63_RS12825	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
EGM63_RS12830	COG1034	ATP synthesis coupled electron transport
EGM63_RS12850	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EGM63_RS12890	COG1960	acyl-CoA dehydrogenase activity
EGM63_RS12900	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EGM63_RS12905	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EGM63_RS12925	COG1960	acyl-CoA dehydrogenase activity
EGM63_RS12935	COG0483	inositol monophosphate 1-phosphatase activity
EGM63_RS12985	COG0493	'glutamate synthase
EGM63_RS12995	COG0668	transmembrane transport
EGM63_RS13005	COG2884	Cell division ATP-binding protein ftsE
EGM63_RS13010	COG2177	Part of the ABC transporter FtsEX involved in
EGM63_RS13015	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
EGM63_RS13050	COG1819	glycosyl
EGM63_RS13075	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EGM63_RS13105	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
EGM63_RS13115	COG2301	Belongs to the HpcH HpaI aldolase family
EGM63_RS13135	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
EGM63_RS13140	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
EGM63_RS13150	COG0477	Major facilitator Superfamily
EGM63_RS13165	COG3654	unkown
EGM63_RS13185	COG4638	Rieske (2fe-2S)
EGM63_RS13210	COG1028	Short-chain dehydrogenase reductase Sdr
EGM63_RS13215	COG4638	Rieske (2fe-2S)
EGM63_RS13225	COG2175	clavaminate synthase activity
EGM63_RS13235	COG0148	phosphopyruvate hydratase activity
EGM63_RS13270	COG2076	Multidrug Resistance protein
EGM63_RS13280	COG1028	Short-chain dehydrogenase reductase Sdr
EGM63_RS13305	COG1024	Enoyl-CoA hydratase
EGM63_RS13310	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EGM63_RS13315	COG0443	Heat shock 70 kDa protein
EGM63_RS13320	COG1966	Carbon starvation protein
EGM63_RS13325	COG1793	dna ligase
EGM63_RS13335	COG1960	acyl-CoA dehydrogenase activity
EGM63_RS13350	COG2186	Transcriptional regulator
EGM63_RS13420	COG1309	transcriptional regulator
EGM63_RS13425	COG2072	flavoprotein involved in K transport
EGM63_RS13430	COG1309	transcriptional regulator
EGM63_RS13435	COG2867	negative regulation of translational initiation
EGM63_RS13435	COG2226	methyltransferase
EGM63_RS13440	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EGM63_RS13460	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EGM63_RS13470	COG1119	ATPase activity
EGM63_RS13480	COG1024	Enoyl-CoA hydratase
EGM63_RS13505	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EGM63_RS13510	COG0110	maltose O-acetyltransferase activity
EGM63_RS13520	COG0415	Belongs to the DNA photolyase family
EGM63_RS13530	COG2409	Drug exporters of the RND superfamily
EGM63_RS13535	COG1304	FMN binding
EGM63_RS13540	COG2801	Transposase and inactivated derivatives
EGM63_RS13540	COG3415	Transposase
EGM63_RS13590	COG0142	geranyltranstransferase activity
EGM63_RS13655	COG0482	sulfurtransferase activity
EGM63_RS13675	COG0626	cystathionine gamma-synthase activity
EGM63_RS13715	COG0154	amidase activity
EGM63_RS13720	COG0205	6-phosphofructokinase activity
EGM63_RS13725	COG1192	Involved in chromosome partitioning
EGM63_RS13740	COG2259	Doxx family
EGM63_RS13765	COG0655	NAD(P)H dehydrogenase (quinone) activity
EGM63_RS13780	COG0473	3-isopropylmalate dehydrogenase activity
EGM63_RS13785	COG2271	Major facilitator Superfamily
EGM63_RS13790	COG0179	Fumarylacetoacetate (FAA) hydrolase
EGM63_RS13795	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EGM63_RS13820	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
EGM63_RS13825	COG0066	3-isopropylmalate dehydratase activity
EGM63_RS13840	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
EGM63_RS13845	COG1920	GTP binding
EGM63_RS13850	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
EGM63_RS13855	COG1181	Belongs to the D-alanine--D-alanine ligase family
EGM63_RS13870	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
EGM63_RS13910	COG1461	Dihydroxyacetone kinase
EGM63_RS13925	COG0656	L-ascorbic acid biosynthetic process
EGM63_RS13935	COG0657	acetylesterase activity
EGM63_RS13950	COG0742	ribosomal rna small subunit methyltransferase
EGM63_RS13965	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
EGM63_RS13970	COG0701	Predicted permease
EGM63_RS13990	COG0571	ribonuclease III activity
EGM63_RS13995	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
EGM63_RS14000	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EGM63_RS14015	COG1196	nuclear chromosome segregation
EGM63_RS14035	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
EGM63_RS14070	COG1686	Belongs to the peptidase S11 family
EGM63_RS14090	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
EGM63_RS14095	COG0336	Belongs to the RNA methyltransferase TrmD family
EGM63_RS14115	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EGM63_RS14135	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
EGM63_RS14145	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
EGM63_RS14210	COG0052	Belongs to the universal ribosomal protein uS2 family
EGM63_RS14215	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
EGM63_RS14220	COG0154	amidase activity
EGM63_RS14235	COG1028	Short-chain dehydrogenase reductase Sdr
EGM63_RS14250	COG0745	RESPONSE REGULATOR receiver
EGM63_RS14260	COG0528	UMP kinase activity
EGM63_RS14270	COG0575	Belongs to the CDS family
EGM63_RS14275	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EGM63_RS14295	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
EGM63_RS14300	COG0750	zinc metalloprotease
EGM63_RS14305	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
EGM63_RS14330	COG1492	cobalamin metabolic process
EGM63_RS14345	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
EGM63_RS14350	COG1012	belongs to the aldehyde dehydrogenase family
EGM63_RS14355	COG1028	Short-chain dehydrogenase reductase Sdr
EGM63_RS14375	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
EGM63_RS14390	COG0579	oxidoreductase
EGM63_RS14420	COG1648	precorrin-2 dehydrogenase activity
EGM63_RS14420	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EGM63_RS14435	COG0442	prolyl-tRNA aminoacylation
EGM63_RS14450	COG0779	Required for maturation of 30S ribosomal subunits
EGM63_RS14465	COG0481	GTPase activity
EGM63_RS14475	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
EGM63_RS14485	COG1024	Enoyl-CoA hydratase
EGM63_RS14510	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
EGM63_RS14515	COG2977	Belongs to the P-Pant transferase superfamily
EGM63_RS14520	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
EGM63_RS14525	COG0183	Belongs to the thiolase family
EGM63_RS14530	COG1960	acyl-CoA dehydrogenase activity
EGM63_RS14550	COG1185	polyribonucleotide nucleotidyltransferase activity
EGM63_RS14565	COG0686	Belongs to the AlaDH PNT family
EGM63_RS14610	COG1403	HNH endonuclease
EGM63_RS14620	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
EGM63_RS14640	COG0318	PFAM AMP-dependent synthetase and ligase
EGM63_RS14645	COG4770	biotin carboxylase activity
EGM63_RS14655	COG1028	Short-chain dehydrogenase reductase Sdr
EGM63_RS14670	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
EGM63_RS14685	COG3214	Protein conserved in bacteria
EGM63_RS14700	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EGM63_RS14725	COG1674	ftsk spoiiie
EGM63_RS14730	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
EGM63_RS14760	COG4308	Limonene-1,2-epoxide hydrolase catalytic domain
EGM63_RS14795	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EGM63_RS14805	COG1196	nuclear chromosome segregation
EGM63_RS14820	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
EGM63_RS14825	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
EGM63_RS14830	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EGM63_RS14845	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EGM63_RS14850	COG1388	LysM domain
EGM63_RS14860	COG4044	May play a role in the intracellular transport of hydrophobic ligands
EGM63_RS14945	COG0483	inositol monophosphate 1-phosphatase activity
EGM63_RS14995	COG0569	domain protein
EGM63_RS15000	COG0531	amino acid
EGM63_RS15005	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EGM63_RS15010	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
EGM63_RS15020	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
EGM63_RS15040	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
EGM63_RS15065	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EGM63_RS15135	COG1012	belongs to the aldehyde dehydrogenase family
EGM63_RS15145	COG1028	Short-chain dehydrogenase reductase Sdr
EGM63_RS15155	COG1309	transcriptional regulator
EGM63_RS15340	COG4974	Belongs to the 'phage' integrase family
EGM63_RS15380	COG1024	Enoyl-CoA hydratase
EGM63_RS15395	COG1028	Short-chain dehydrogenase reductase Sdr
EGM63_RS15400	COG0753	catalase activity
EGM63_RS15410	COG1366	Belongs to the anti-sigma-factor antagonist family
EGM63_RS15430	COG1414	Transcriptional regulator
EGM63_RS15470	COG3485	protocatechuate 3,4-dioxygenase
EGM63_RS15475	COG3485	protocatechuate 3,4-dioxygenase
EGM63_RS15525	COG4762	Protein conserved in bacteria
EGM63_RS15530	COG0667	Aldo Keto reductase
EGM63_RS15545	COG0025	NhaP-type Na H and K H
EGM63_RS15550	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EGM63_RS15585	COG1946	Acyl-CoA thioesterase
EGM63_RS15590	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
EGM63_RS15600	COG1331	Highly conserved protein containing a thioredoxin domain
EGM63_RS15630	COG0572	uridine kinase
EGM63_RS15635	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EGM63_RS15645	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
EGM63_RS15685	COG2272	Belongs to the type-B carboxylesterase lipase family
EGM63_RS15700	COG1570	exodeoxyribonuclease VII activity
EGM63_RS15710	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
EGM63_RS15720	COG0012	GTP binding
EGM63_RS15795	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
EGM63_RS15825	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EGM63_RS15825	COG0574	Belongs to the PEP-utilizing enzyme family
EGM63_RS15840	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
EGM63_RS15855	COG1309	transcriptional regulator
EGM63_RS15865	COG1960	acyl-CoA dehydrogenase activity
EGM63_RS15870	COG1960	acyl-CoA dehydrogenase activity
EGM63_RS15880	COG0714	Associated with various cellular activities
EGM63_RS15895	COG1028	Short-chain dehydrogenase reductase Sdr
EGM63_RS15900	COG2124	cytochrome p450
EGM63_RS15910	COG0183	Belongs to the thiolase family
EGM63_RS15915	COG1024	Enoyl-CoA hydratase
EGM63_RS15935	COG0702	epimerase
EGM63_RS15945	COG1024	Enoyl-CoA hydratase
EGM63_RS15950	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EGM63_RS15970	COG2409	Drug exporters of the RND superfamily
EGM63_RS15980	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
EGM63_RS15995	COG3467	pyridoxamine 5'-phosphate
EGM63_RS16030	COG2154	pterin-4-alpha-carbinolamine dehydratase
EGM63_RS16050	COG1140	nitrate reductase beta subunit
EGM63_RS16065	COG1217	gtp-binding protein TYPA
EGM63_RS16080	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EGM63_RS16090	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
EGM63_RS16105	COG3415	Transposase
EGM63_RS16105	COG2801	Transposase and inactivated derivatives
EGM63_RS16110	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
EGM63_RS16120	COG0531	amino acid
EGM63_RS16155	COG0529	Catalyzes the synthesis of activated sulfate
EGM63_RS16160	COG2046	Belongs to the sulfate adenylyltransferase family
EGM63_RS16170	COG0318	PFAM AMP-dependent synthetase and ligase
EGM63_RS16185	COG1012	belongs to the aldehyde dehydrogenase family
EGM63_RS16190	COG0506	proline dehydrogenase activity
EGM63_RS16210	COG1960	acyl-CoA dehydrogenase activity
EGM63_RS16225	COG1960	acyl-CoA dehydrogenase activity
EGM63_RS16230	COG2124	cytochrome p450
EGM63_RS16240	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EGM63_RS16250	COG0318	PFAM AMP-dependent synthetase and ligase
EGM63_RS16255	COG0477	Major facilitator Superfamily
EGM63_RS16295	COG1611	Belongs to the LOG family
EGM63_RS16300	COG0318	PFAM AMP-dependent synthetase and ligase
EGM63_RS16310	COG0463	Glycosyl transferase, family 2
EGM63_RS16320	COG0519	Catalyzes the synthesis of GMP from XMP
EGM63_RS16340	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
EGM63_RS16355	COG3559	Exporter of polyketide antibiotics
EGM63_RS16360	COG1131	(ABC) transporter
EGM63_RS16370	COG4122	O-methyltransferase activity
EGM63_RS16380	COG5662	AntiSigma factor
EGM63_RS16385	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EGM63_RS16390	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EGM63_RS16410	COG2239	Acts as a magnesium transporter
EGM63_RS16455	COG0598	Magnesium transport protein CorA
EGM63_RS16460	COG0039	L-malate dehydrogenase activity
EGM63_RS16485	COG0567	Dehydrogenase, E1 component
EGM63_RS16485	COG0508	dehydrogenase complex catalyzes the overall conversion of
EGM63_RS16515	COG1028	Short-chain dehydrogenase reductase Sdr
EGM63_RS16525	COG1028	Short-chain dehydrogenase reductase Sdr
EGM63_RS16535	COG1028	Short-chain dehydrogenase reductase Sdr
EGM63_RS16585	COG0277	FAD linked oxidase domain protein
EGM63_RS16605	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EGM63_RS16690	COG1403	HNH endonuclease
EGM63_RS16780	COG3631	Ketosteroid isomerase-related protein
EGM63_RS16785	COG0494	nUDIX hydrolase
EGM63_RS16830	COG0018	arginyl-trna synthetase
EGM63_RS16840	COG0460	homoserine dehydrogenase
EGM63_RS16850	COG0083	homoserine kinase activity
EGM63_RS16870	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
EGM63_RS16875	COG2890	protein-(glutamine-N5) methyltransferase activity
EGM63_RS16895	COG0356	it plays a direct role in the translocation of protons across the membrane
EGM63_RS16900	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EGM63_RS16910	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EGM63_RS16910	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EGM63_RS16925	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
EGM63_RS16945	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
EGM63_RS16970	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EGM63_RS16990	COG0583	DNA-binding transcription factor activity
EGM63_RS16995	COG2814	Major facilitator Superfamily
EGM63_RS17020	COG0346	lactoylglutathione lyase activity
EGM63_RS17035	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
EGM63_RS17045	COG0058	SHG alpha-glucan phosphorylase activity
EGM63_RS17055	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
EGM63_RS17070	COG3191	aminopeptidase activity
EGM63_RS17080	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
EGM63_RS17085	COG1234	tRNA 3'-trailer cleavage
EGM63_RS17090	COG2123	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
EGM63_RS17095	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
EGM63_RS17155	COG1028	Short-chain dehydrogenase reductase Sdr
EGM63_RS17160	COG1960	acyl-CoA dehydrogenase activity
EGM63_RS17170	COG0183	Belongs to the thiolase family
EGM63_RS17175	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EGM63_RS17180	COG1960	acyl-CoA dehydrogenase activity
EGM63_RS17185	COG1802	Transcriptional regulator
EGM63_RS17195	COG0318	PFAM AMP-dependent synthetase and ligase
EGM63_RS17210	COG1024	Enoyl-CoA hydratase
EGM63_RS17215	COG1024	Enoyl-CoA hydratase
EGM63_RS17220	COG1024	Enoyl-CoA hydratase
EGM63_RS17240	COG1028	Short-chain dehydrogenase reductase Sdr
EGM63_RS17255	COG1024	Enoyl-CoA hydratase
EGM63_RS17280	COG1960	acyl-CoA dehydrogenase activity
EGM63_RS17285	COG0183	Belongs to the thiolase family
EGM63_RS17295	COG2124	cytochrome p450
EGM63_RS17320	COG4638	Rieske (2fe-2S)
EGM63_RS17325	COG2072	flavoprotein involved in K transport
EGM63_RS17345	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EGM63_RS17360	COG1309	transcriptional regulator
EGM63_RS17380	COG2124	cytochrome p450
EGM63_RS17385	COG0657	acetylesterase activity
EGM63_RS17390	COG1960	acyl-CoA dehydrogenase activity
EGM63_RS17395	COG1960	acyl-CoA dehydrogenase activity
EGM63_RS17410	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
EGM63_RS17440	COG1960	acyl-CoA dehydrogenase activity
EGM63_RS17445	COG1960	acyl-CoA dehydrogenase activity
EGM63_RS17450	COG1960	acyl-CoA dehydrogenase activity
EGM63_RS17455	COG1960	acyl-CoA dehydrogenase activity
EGM63_RS17485	COG2124	cytochrome p450
EGM63_RS17535	COG3757	hydrolase, family 25
EGM63_RS17550	COG0736	holo-[acyl-carrier-protein] synthase activity
EGM63_RS17555	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EGM63_RS17585	COG4552	Acetyltransferase involved in intracellular survival and related
EGM63_RS17590	COG2409	Drug exporters of the RND superfamily
EGM63_RS17600	COG1376	ErfK ybiS ycfS ynhG family protein
EGM63_RS17615	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
EGM63_RS17620	COG0433	COG0433 Predicted ATPase
EGM63_RS17625	COG0300	oxidoreductase activity
EGM63_RS17645	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EGM63_RS17655	COG1960	acyl-CoA dehydrogenase activity
EGM63_RS17660	COG2030	dehydratase
EGM63_RS17680	COG0508	dehydrogenase complex catalyzes the overall conversion of
EGM63_RS17710	COG3415	Transposase
EGM63_RS17710	COG2801	Transposase and inactivated derivatives
EGM63_RS17720	COG0657	acetylesterase activity
EGM63_RS17735	COG2937	Belongs to the GPAT DAPAT family
EGM63_RS17745	COG0629	single-stranded DNA binding
EGM63_RS17755	COG2902	Dehydrogenase
EGM63_RS17780	COG2346	COG2346, Truncated hemoglobins
EGM63_RS17805	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
EGM63_RS17810	COG0698	ribose 5-phosphate isomerase
EGM63_RS17825	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EGM63_RS17845	COG0740	serine-type endopeptidase activity
EGM63_RS17850	COG0740	serine-type endopeptidase activity
EGM63_RS17855	COG2040	homocysteine
EGM63_RS17865	COG0674	pyruvate-flavodoxin oxidoreductase activity
EGM63_RS17865	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
EGM63_RS17870	COG1013	pyruvate-flavodoxin oxidoreductase activity
EGM63_RS17875	COG0746	molybdenum cofactor guanylyltransferase activity
EGM63_RS17880	COG3328	transposase activity
EGM63_RS17885	COG1388	LysM domain
EGM63_RS17890	COG3268	Saccharopine dehydrogenase
EGM63_RS17895	COG0525	valine-tRNA ligase activity
EGM63_RS17900	COG0285	dihydrofolate synthase activity
EGM63_RS17910	COG0105	UTP biosynthetic process
EGM63_RS17915	COG1530	ribonuclease E activity
EGM63_RS17930	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EGM63_RS17935	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
EGM63_RS17970	COG0066	3-isopropylmalate dehydratase activity
EGM63_RS17975	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
EGM63_RS17990	COG2188	Transcriptional regulator
EGM63_RS17995	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EGM63_RS18000	COG5002	protein histidine kinase activity
EGM63_RS18010	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
EGM63_RS18015	COG0542	response to heat
EGM63_RS18025	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
EGM63_RS18030	COG0799	negative regulation of ribosome biogenesis
EGM63_RS18040	COG2755	lipolytic protein G-D-S-L family
EGM63_RS18070	COG0318	PFAM AMP-dependent synthetase and ligase
EGM63_RS18075	COG5651	PPE family
EGM63_RS18100	COG1960	acyl-CoA dehydrogenase activity
EGM63_RS18105	COG1960	acyl-CoA dehydrogenase activity
EGM63_RS18110	COG1555	photosystem II stabilization
EGM63_RS18110	COG1596	polysaccharide export
EGM63_RS18115	COG0658	competence protein
EGM63_RS18115	COG2333	competence protein COMEC
EGM63_RS18130	COG2308	Evidence 4 Homologs of previously reported genes of
EGM63_RS18140	COG1305	Transglutaminase-like
EGM63_RS18160	COG0481	GTPase activity
EGM63_RS18170	COG3387	PFAM Glycoside hydrolase 15-related
EGM63_RS18185	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
EGM63_RS18190	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
EGM63_RS18195	COG4208	sulfate ABC transporter
EGM63_RS18200	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
EGM63_RS18210	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EGM63_RS18230	COG1169	isochorismate synthase
EGM63_RS18245	COG2072	flavoprotein involved in K transport
EGM63_RS18255	COG0300	oxidoreductase activity
EGM63_RS18260	COG0657	acetylesterase activity
EGM63_RS18285	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EGM63_RS18340	COG1309	transcriptional regulator
EGM63_RS18360	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EGM63_RS18375	COG0604	alcohol dehydrogenase
EGM63_RS18375	COG3321	synthase
EGM63_RS18390	COG3486	L-lysine 6-monooxygenase (NADPH) activity
EGM63_RS18410	COG1595	DNA-templated transcription, initiation
EGM63_RS18425	COG1420	regulation of RNA biosynthetic process
EGM63_RS18430	COG0484	heat shock protein binding
EGM63_RS18445	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
EGM63_RS18515	COG3328	transposase activity
EGM63_RS18545	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
EGM63_RS18550	COG1982	Orn Lys Arg decarboxylase major
EGM63_RS18560	COG1381	Involved in DNA repair and RecF pathway recombination
EGM63_RS18585	COG0423	glycine-tRNA ligase activity
EGM63_RS18635	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EGM63_RS18640	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EGM63_RS18650	COG1045	serine acetyltransferase
EGM63_RS18670	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EGM63_RS18675	COG2855	membrane
EGM63_RS18680	COG4424	Sulfotransferase
EGM63_RS18685	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EGM63_RS18715	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EGM63_RS18755	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
EGM63_RS18760	COG0243	molybdopterin cofactor binding
EGM63_RS18770	COG2223	nitrite transmembrane transporter activity
EGM63_RS18780	COG1716	ATPase activity
EGM63_RS18780	COG1131	(ABC) transporter
EGM63_RS18780	COG0842	Transport permease protein
EGM63_RS18800	COG1522	sequence-specific DNA binding
EGM63_RS18805	COG1834	amidinotransferase
EGM63_RS18810	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EGM63_RS18815	COG0531	amino acid
EGM63_RS18825	COG0395	ABC-type sugar transport system, permease component
EGM63_RS18830	COG1175	transmembrane transport
EGM63_RS18875	COG1012	belongs to the aldehyde dehydrogenase family
EGM63_RS18885	COG0563	adenylate kinase activity
EGM63_RS18890	COG2814	Major facilitator Superfamily
EGM63_RS18900	COG3903	Transcriptional regulator
EGM63_RS18900	COG3629	intracellular signal transduction
EGM63_RS18920	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
EGM63_RS18925	COG2226	methyltransferase
EGM63_RS18955	COG0326	Molecular chaperone. Has ATPase activity
EGM63_RS18975	COG2239	Acts as a magnesium transporter
EGM63_RS18990	COG0697	spore germination
EGM63_RS19015	COG0596	Alpha beta hydrolase
EGM63_RS19025	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
EGM63_RS19030	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EGM63_RS19045	COG2124	cytochrome p450
EGM63_RS19050	COG3547	Transposase (IS116 IS110 IS902 family)
EGM63_RS19075	COG0438	transferase activity, transferring glycosyl groups
EGM63_RS19080	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EGM63_RS19095	COG0657	acetylesterase activity
EGM63_RS19105	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
EGM63_RS19125	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EGM63_RS19170	COG1487	ribonuclease activity
EGM63_RS19200	COG0860	N-Acetylmuramoyl-L-alanine amidase
EGM63_RS19215	COG2072	flavoprotein involved in K transport
EGM63_RS19275	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EGM63_RS19305	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EGM63_RS19325	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EGM63_RS19370	COG0596	Alpha beta hydrolase
EGM63_RS19380	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
EGM63_RS19470	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
EGM63_RS19495	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
EGM63_RS19525	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
EGM63_RS19530	COG0321	lipoyl(octanoyl) transferase activity
EGM63_RS19560	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EGM63_RS19570	COG0404	The glycine cleavage system catalyzes the degradation of glycine
EGM63_RS19575	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EGM63_RS19580	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
EGM63_RS19585	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
EGM63_RS19615	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EGM63_RS19630	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
EGM63_RS19670	COG1845	cytochrome c oxidase, subunit III
EGM63_RS19675	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EGM63_RS19705	COG1022	Amp-dependent synthetase and ligase
EGM63_RS19720	COG0003	Pfam Anion-transporting ATPase
EGM63_RS19750	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
EGM63_RS19755	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EGM63_RS19775	COG0142	geranyltranstransferase activity
EGM63_RS19805	COG0275	rRNA processing
EGM63_RS19815	COG0768	penicillin binding
EGM63_RS19820	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EGM63_RS19835	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
EGM63_RS19845	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EGM63_RS19850	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EGM63_RS19865	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EGM63_RS19880	COG1799	cell septum assembly
EGM63_RS19915	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EGM63_RS19925	COG1403	HNH endonuclease
EGM63_RS19930	COG0167	dihydroorotate dehydrogenase activity
EGM63_RS19965	COG1218	3'(2'),5'-bisphosphate nucleotidase
EGM63_RS19975	COG0215	cysteine-tRNA ligase activity
EGM63_RS19990	COG0028	Belongs to the TPP enzyme family
EGM63_RS20000	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EGM63_RS20035	COG1028	Short-chain dehydrogenase reductase Sdr
EGM63_RS20045	COG1410	methionine synthase
EGM63_RS20045	COG0646	methionine synthase
EGM63_RS20090	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EGM63_RS20105	COG0140	phosphoribosyl-ATP diphosphatase activity
EGM63_RS20165	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
EGM63_RS20185	COG2378	regulation of single-species biofilm formation
EGM63_RS20220	COG2826	transposase and inactivated derivatives, IS30 family
EGM63_RS20300	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EGM63_RS20330	COG0412	Dienelactone hydrolase
EGM63_RS20340	COG1574	metal-dependent hydrolase with the TIM-barrel fold
EGM63_RS20365	COG0604	alcohol dehydrogenase
EGM63_RS20365	COG3321	synthase
EGM63_RS20395	COG0714	Associated with various cellular activities
EGM63_RS20455	COG2272	Belongs to the type-B carboxylesterase lipase family
EGM63_RS20465	COG3265	gluconokinase activity
EGM63_RS20485	COG1335	isochorismatase
EGM63_RS20510	COG1595	DNA-templated transcription, initiation
EGM63_RS20520	COG1175	transmembrane transport
EGM63_RS20525	COG0395	ABC-type sugar transport system, permease component
EGM63_RS20530	COG3842	ATPase activity
EGM63_RS20535	COG1752	Esterase of the alpha-beta hydrolase superfamily
EGM63_RS20560	COG2837	iron assimilation
EGM63_RS20600	COG0667	Aldo Keto reductase
EGM63_RS20605	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EGM63_RS20620	COG1960	acyl-CoA dehydrogenase activity
EGM63_RS20685	COG0657	acetylesterase activity
EGM63_RS20715	COG1946	Acyl-CoA thioesterase
EGM63_RS20745	COG0753	catalase activity
EGM63_RS20810	COG1028	Short-chain dehydrogenase reductase Sdr
EGM63_RS20820	COG0183	Belongs to the thiolase family
EGM63_RS20825	COG1960	acyl-CoA dehydrogenase activity
EGM63_RS20835	COG1309	transcriptional regulator
EGM63_RS20840	COG2267	carboxylic ester hydrolase activity
EGM63_RS20855	COG1028	Short-chain dehydrogenase reductase Sdr
EGM63_RS20900	COG0301	tRNA thio-modification
EGM63_RS20910	COG0789	Transcriptional regulator
EGM63_RS20920	COG0484	heat shock protein binding
EGM63_RS20930	COG0545	Peptidyl-prolyl cis-trans isomerase
EGM63_RS20935	COG1028	Short-chain dehydrogenase reductase Sdr
EGM63_RS20955	COG2301	Belongs to the HpcH HpaI aldolase family
EGM63_RS20980	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EGM63_RS20985	COG1643	Atp-dependent helicase
EGM63_RS21000	COG1024	Enoyl-CoA hydratase
EGM63_RS21045	COG0723	plastoquinol--plastocyanin reductase activity
EGM63_RS21055	COG1376	ErfK ybiS ycfS ynhG family protein
EGM63_RS21065	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
EGM63_RS21070	COG3757	hydrolase, family 25
EGM63_RS21075	COG0438	transferase activity, transferring glycosyl groups
EGM63_RS21080	COG2226	methyltransferase
EGM63_RS21110	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
EGM63_RS21125	COG1012	belongs to the aldehyde dehydrogenase family
EGM63_RS21155	COG4977	sequence-specific DNA binding
EGM63_RS21210	COG0640	Transcriptional regulator
EGM63_RS21230	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
EGM63_RS21290	COG1950	PFAM Membrane protein of
EGM63_RS21300	COG2814	Major facilitator Superfamily
EGM63_RS21305	COG1058	Belongs to the CinA family
EGM63_RS21305	COG1546	Belongs to the CinA family
EGM63_RS21315	COG1490	D-aminoacyl-tRNA deacylase activity
EGM63_RS21320	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
EGM63_RS21325	COG1063	alcohol dehydrogenase
EGM63_RS21335	COG1403	HNH endonuclease
EGM63_RS21340	COG2070	2-Nitropropane dioxygenase
EGM63_RS21395	COG1652	LysM domain
EGM63_RS21435	COG0174	glutamine synthetase
EGM63_RS21445	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EGM63_RS21455	COG2193	ferroxidase activity
EGM63_RS21465	COG1024	Enoyl-CoA hydratase
EGM63_RS21490	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EGM63_RS21545	COG0183	Belongs to the thiolase family
EGM63_RS21550	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EGM63_RS21555	COG1968	undecaprenyl-diphosphatase activity
EGM63_RS21560	COG4221	oxidoreductase activity
EGM63_RS21565	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
EGM63_RS21615	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EGM63_RS21625	COG1252	NADH dehydrogenase
EGM63_RS21645	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
EGM63_RS21655	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EGM63_RS21660	COG0318	PFAM AMP-dependent synthetase and ligase
EGM63_RS21665	COG1960	acyl-CoA dehydrogenase activity
EGM63_RS21675	COG1253	flavin adenine dinucleotide binding
EGM63_RS21680	COG1253	flavin adenine dinucleotide binding
EGM63_RS21685	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
EGM63_RS21705	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EGM63_RS21705	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EGM63_RS21755	COG0653	protein targeting
EGM63_RS21770	COG1053	succinate dehydrogenase
EGM63_RS21800	COG1285	pathogenesis
EGM63_RS21810	COG5651	PPE family
EGM63_RS21855	COG0657	acetylesterase activity
EGM63_RS21870	COG1404	Belongs to the peptidase S8 family
EGM63_RS21900	COG5651	PPE family
EGM63_RS21910	COG5651	PPE family
EGM63_RS21950	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
EGM63_RS21985	COG1028	Short-chain dehydrogenase reductase Sdr
EGM63_RS21990	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EGM63_RS21995	COG0022	dehydrogenase e1 component
EGM63_RS22005	COG1024	Enoyl-CoA hydratase
EGM63_RS22020	COG1053	succinate dehydrogenase
EGM63_RS22030	COG0513	Belongs to the DEAD box helicase family
EGM63_RS22035	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EGM63_RS22095	COG4221	oxidoreductase activity
EGM63_RS22115	COG0318	PFAM AMP-dependent synthetase and ligase
EGM63_RS22120	COG2072	flavoprotein involved in K transport
EGM63_RS22145	COG1960	acyl-CoA dehydrogenase activity
EGM63_RS22150	COG1960	acyl-CoA dehydrogenase activity
EGM63_RS22155	COG0842	Transport permease protein
EGM63_RS22155	COG1131	(ABC) transporter
EGM63_RS22155	COG1716	ATPase activity
EGM63_RS22160	COG0657	acetylesterase activity
EGM63_RS22165	COG1028	Short-chain dehydrogenase reductase Sdr
EGM63_RS22185	COG2267	carboxylic ester hydrolase activity
EGM63_RS22195	COG2072	flavoprotein involved in K transport
EGM63_RS22225	COG0657	acetylesterase activity
EGM63_RS22240	COG1028	Short-chain dehydrogenase reductase Sdr
EGM63_RS22245	COG2072	flavoprotein involved in K transport
EGM63_RS22260	COG0657	acetylesterase activity
EGM63_RS22270	COG1028	Short-chain dehydrogenase reductase Sdr
EGM63_RS22275	COG1028	Short-chain dehydrogenase reductase Sdr
EGM63_RS22290	COG1053	succinate dehydrogenase
EGM63_RS22295	COG1403	HNH endonuclease
EGM63_RS22320	COG2132	Multicopper oxidase
EGM63_RS22340	COG2271	Major facilitator Superfamily
EGM63_RS22345	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EGM63_RS22345	COG0189	ligase activity
EGM63_RS22385	COG1160	GTP binding
EGM63_RS22390	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
EGM63_RS22400	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
EGM63_RS22425	COG0494	nUDIX hydrolase
EGM63_RS22450	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
EGM63_RS22465	COG0647	UMP catabolic process
EGM63_RS22480	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
EGM63_RS22485	COG2094	Belongs to the DNA glycosylase MPG family
EGM63_RS22495	COG1131	(ABC) transporter
EGM63_RS22505	COG1309	transcriptional regulator
EGM63_RS22510	COG2835	tetraacyldisaccharide 4'-kinase activity
EGM63_RS22545	COG0300	oxidoreductase activity
EGM63_RS22550	COG4948	Mandelate Racemase Muconate Lactonizing
EGM63_RS22555	COG1028	Short-chain dehydrogenase reductase Sdr
EGM63_RS22560	COG1028	Short-chain dehydrogenase reductase Sdr
EGM63_RS22580	COG0583	DNA-binding transcription factor activity
EGM63_RS22590	COG0488	(ABC) transporter
EGM63_RS22605	COG0604	alcohol dehydrogenase
EGM63_RS22605	COG3321	synthase
EGM63_RS22605	COG0604	alcohol dehydrogenase
EGM63_RS22605	COG3321	synthase
EGM63_RS22630	COG0165	Argininosuccinate lyase
EGM63_RS22635	COG0137	argininosuccinate synthase activity
EGM63_RS22640	COG1438	arginine binding
EGM63_RS22645	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
EGM63_RS22655	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EGM63_RS22660	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
EGM63_RS22665	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
EGM63_RS22670	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EGM63_RS22670	COG0072	phenylalanine-tRNA ligase activity
EGM63_RS22675	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
EGM63_RS22715	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
EGM63_RS22715	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
EGM63_RS22730	COG1309	transcriptional regulator
EGM63_RS22790	COG1285	pathogenesis
EGM63_RS22825	COG1716	ATPase activity
EGM63_RS22825	COG1131	(ABC) transporter
EGM63_RS22825	COG0842	Transport permease protein
EGM63_RS22840	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
EGM63_RS22850	COG0237	dephospho-CoA kinase activity
EGM63_RS22850	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EGM63_RS22860	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
EGM63_RS22880	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EGM63_RS22910	COG1271	oxidase subunit
EGM63_RS22915	COG1294	oxidase, subunit
EGM63_RS22920	COG4988	ABC transporter
EGM63_RS22925	COG1132	(ABC) transporter
EGM63_RS22935	COG1946	Acyl-CoA thioesterase
EGM63_RS22955	COG0159	tryptophan synthase activity
EGM63_RS22985	COG0387	Pfam Sodium calcium exchanger
EGM63_RS22990	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
EGM63_RS22995	COG0107	imidazoleglycerol-phosphate synthase activity
EGM63_RS23000	COG0483	inositol monophosphate 1-phosphatase activity
EGM63_RS23005	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
EGM63_RS23010	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
EGM63_RS23020	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EGM63_RS23025	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
EGM63_RS23035	COG0157	Belongs to the NadC ModD family
EGM63_RS23040	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate