locus-tag class description G6N66_RS00070 ENOG4106YT9 Enoyl-CoA hydratase G6N66_RS00135 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) G6N66_RS00160 ENOG4105CEY Amp-dependent synthetase and ligase G6N66_RS00180 ENOG4105C26 Dehydrogenase G6N66_RS00230 ENOG41073B4 coagulation factor 5 8 type domain-containing protein G6N66_RS00260 ENOG4105CHR reductase G6N66_RS00265 ENOG4105CHU acetyl-coa acetyltransferase G6N66_RS00270 ENOG4105CSU acyl-Coa dehydrogenase G6N66_RS00280 ENOG4105MXW flavin reductase domain protein, FMN-binding G6N66_RS00300 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) G6N66_RS00330 ENOG4107QZF nitrite reductase NADPH large subunit G6N66_RS00350 ENOG4108KXV response regulator G6N66_RS00390 ENOG4105CEY Amp-dependent synthetase and ligase G6N66_RS00405 ENOG4105D2B acyl-CoA dehydrogenase G6N66_RS00445 ENOG4105IIV Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) G6N66_RS00500 ENOG41090GG peptidase S8 and S53, subtilisin, kexin, sedolisin G6N66_RS00530 ENOG4105E7Q Cob(II)yrinic acid a,c-diamide reductase G6N66_RS00545 ENOG4105HMD G6N66_RS00580 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein G6N66_RS00640 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) G6N66_RS00645 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) G6N66_RS00655 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family G6N66_RS00705 ENOG4105CHR reductase G6N66_RS00755 ENOG4107R3N Filamentation induced by cAMP protein fic G6N66_RS00805 ENOG4106CY5 excisionase G6N66_RS00815 ENOG4107T65 Integrase G6N66_RS00850 ENOG4105C6Y Udp-glucose 6-dehydrogenase G6N66_RS00900 ENOG4105DF6 Fe-S oxidoreductase G6N66_RS00915 ENOG4105E0X reductase G6N66_RS00995 ENOG4105KNI merR family transcriptional Regulator G6N66_RS01030 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit G6N66_RS01090 ENOG4105XRQ Xanthine dehydrogenase accessory factor G6N66_RS01120 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding G6N66_RS01125 ENOG4108XHQ (2Fe-2S)-binding domain protein G6N66_RS01135 ENOG4107XFB conserved TRANSMEMBRANE PROTEIN G6N66_RS01140 ENOG4107RCW fructose-bisphosphate aldolase G6N66_RS01160 ENOG4107XZ0 Peptidase M50 G6N66_RS01185 ENOG4107SPG Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR G6N66_RS01190 ENOG4105F8J Adenylate Guanylate cyclase G6N66_RS01200 ENOG4105MGE Rhodanese domain protein G6N66_RS01210 ENOG4105CEP NADH dehydrogenase G6N66_RS01255 ENOG4105C1G acyl-Coa dehydrogenase G6N66_RS01260 ENOG4105CHR reductase G6N66_RS01285 ENOG4105DEN Luciferase family G6N66_RS01295 ENOG4105C5X domain protein G6N66_RS01310 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) G6N66_RS01320 ENOG4105F9F transposase G6N66_RS01330 ENOG4105CT1 (ABC) transporter G6N66_RS01385 ENOG4105IIU Aminopeptidase G6N66_RS01390 ENOG4105IIU Aminopeptidase G6N66_RS01405 ENOG4105DYW oxidoreductase G6N66_RS01425 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) G6N66_RS01485 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) G6N66_RS01500 ENOG4105H08 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) G6N66_RS01565 ENOG4105PDP Short chain dehydrogenase G6N66_RS01575 ENOG4107RN6 Monooxygenase G6N66_RS01615 ENOG4107FW0 short-chain dehydrogenase reductase G6N66_RS01715 ENOG4108D7R p-hydroxycinnamoyl CoA hydratase lyase G6N66_RS01780 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase G6N66_RS01800 ENOG4106BRA Membrane G6N66_RS01810 ENOG4105V9F hemagglutinin G6N66_RS01815 ENOG4105TT9 Protein of unknown function (DUF2516) G6N66_RS01870 ENOG4108YZJ Pfam:DUF2596 G6N66_RS01875 ENOG4107RPC Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) G6N66_RS01915 ENOG4107R33 ppx gppa phosphatase G6N66_RS01920 ENOG41063NU Membrane G6N66_RS01955 ENOG4105PSQ Acyl-transferase G6N66_RS01965 ENOG410900P UPF0336 protein G6N66_RS01985 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) G6N66_RS02030 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) G6N66_RS02035 ENOG4105C85 amino acid G6N66_RS02040 ENOG41084M5 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) G6N66_RS02045 ENOG4105CMJ mandelate racemase muconate lactonizing G6N66_RS02060 ENOG4108RH7 phosphoglycerate mutase G6N66_RS02070 ENOG4107QIV Cytochrome c biogenesis protein G6N66_RS02080 ENOG4105CRE cytochrome C G6N66_RS02110 ENOG4107USC Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity) G6N66_RS02115 ENOG4105CMR udp-glucose 4-epimerase G6N66_RS02170 ENOG4105CJ3 phosphate transporter G6N66_RS02180 ENOG4105PDP Short chain dehydrogenase G6N66_RS02200 ENOG4105CEY Amp-dependent synthetase and ligase G6N66_RS02205 ENOG4105CI2 imidazolone-5-propionate hydrolase G6N66_RS02210 ENOG4107TCW O-succinylbenzoate synthase G6N66_RS02235 ENOG4105EMU Dehydrogenase G6N66_RS02295 ENOG4105CHH sulfate transporter G6N66_RS02355 ENOG4105CIR epoxide hydrolase G6N66_RS02380 ENOG4105EAH synthase G6N66_RS02395 ENOG4107SM8 Adenylate Guanylate cyclase G6N66_RS02400 ENOG4105CVN desaturase G6N66_RS02405 ENOG4105EG6 Saccharopine dehydrogenase G6N66_RS02415 ENOG4108KC1 acyl-Coa dehydrogenase G6N66_RS02445 ENOG4105C1J atp-dependent rna helicase G6N66_RS02460 ENOG4105X7H acyl-CoA dehydrogenase G6N66_RS02465 ENOG4108KC2 acyl-Coa dehydrogenase G6N66_RS02490 ENOG4105J5T Amp-dependent synthetase and ligase G6N66_RS02530 ENOG4105YVM Phosphoesterase, PA-phosphatase related G6N66_RS02545 ENOG4105CWX Alpha-1,2-mannosidase G6N66_RS02575 ENOG4105C7H Helicase, RecD TraA family G6N66_RS02580 ENOG4107QKA exodeoxyribonuclease V beta G6N66_RS02585 ENOG4105DSY exodeoxyribonuclease V, gamma G6N66_RS02595 ENOG41089UC methyltransferase, type 11 G6N66_RS02630 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) G6N66_RS02655 ENOG410900P UPF0336 protein G6N66_RS02660 ENOG4108F01 MaoC domain protein G6N66_RS02690 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) G6N66_RS02705 ENOG4105CHP RNA polymerase G6N66_RS02720 ENOG4107RN6 Monooxygenase G6N66_RS02725 ENOG4108NUI synthase G6N66_RS02760 ENOG4105DKQ ROK family G6N66_RS02800 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) G6N66_RS02820 ENOG4105CSU acyl-Coa dehydrogenase G6N66_RS02835 ENOG4105E39 Enoyl-CoA hydratase G6N66_RS02855 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) G6N66_RS02880 ENOG4108BAS reductase G6N66_RS02910 ENOG4105XDV G6N66_RS02935 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) G6N66_RS02945 ENOG4105C57 major facilitator superfamily G6N66_RS02965 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) G6N66_RS02975 ENOG4105KZR One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) G6N66_RS03005 ENOG41082SA 50s ribosomal protein l29 G6N66_RS03015 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) G6N66_RS03035 ENOG4105E6M Sulphatase-modifying factor protein G6N66_RS03065 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) G6N66_RS03075 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) G6N66_RS03100 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) G6N66_RS03125 ENOG4108W6C Dehydrogenase G6N66_RS03130 ENOG4105CPQ Dehydrogenase G6N66_RS03145 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) G6N66_RS03165 ENOG4108JQ1 Dehydrogenase G6N66_RS03170 ENOG4105CMG Carbohydrate kinase G6N66_RS03190 ENOG4108XW1 Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) G6N66_RS03200 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) G6N66_RS03220 ENOG4105C7K acetolactate synthase G6N66_RS03235 ENOG4105CIH Imidazole acetol-phosphate transaminase G6N66_RS03260 ENOG4105C26 Dehydrogenase G6N66_RS03270 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) G6N66_RS03360 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) G6N66_RS03395 ENOG41090GG peptidase S8 and S53, subtilisin, kexin, sedolisin G6N66_RS03405 ENOG4105EC2 ftsk spoIIIe G6N66_RS03460 ENOG4105DYW oxidoreductase G6N66_RS03490 ENOG4105C0I Conserved Protein G6N66_RS03495 ENOG4105CAQ asparagine synthetase G6N66_RS03510 ENOG4105CVK Glutamate decarboxylase G6N66_RS03535 ENOG41080E2 ribosomal-protein-alanine acetyltransferase G6N66_RS03560 ENOG4105F8J Adenylate Guanylate cyclase G6N66_RS03625 ENOG4108VT4 G6N66_RS03650 ENOG4107RCI amp-dependent synthetase and ligase G6N66_RS03685 ENOG4107UVD Beta-phosphoglucomutase family hydrolase G6N66_RS03695 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) G6N66_RS03700 ENOG4105C57 major facilitator superfamily G6N66_RS03710 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) G6N66_RS03730 ENOG4105DMF Dehydrogenase G6N66_RS03800 ENOG4105C0B DNA polymerase III (alpha subunit) G6N66_RS03805 ENOG4105EMU Dehydrogenase G6N66_RS03820 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) G6N66_RS03830 ENOG4105GWZ Roadblock lc7 family protein G6N66_RS03845 ENOG4105IDI abc transporter atp-binding protein G6N66_RS03850 ENOG4105IDI abc transporter atp-binding protein G6N66_RS03875 ENOG4105DNP FAD linked oxidase domain protein G6N66_RS03880 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) G6N66_RS03900 ENOG4108IQK o-acetylhomoserine G6N66_RS03920 ENOG4107S2Z UPF0761 membrane protein G6N66_RS03935 ENOG4105CE4 GlcNAc 6-P deacetylase G6N66_RS03940 ENOG4107QNK )-transporter G6N66_RS03950 ENOG4105DZ1 carboxypeptidase G6N66_RS03965 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) G6N66_RS03970 ENOG4108KPJ rna polymerase sigma factor G6N66_RS03995 ENOG4105E33 succinate dehydrogenase G6N66_RS04060 ENOG4105FBN Acid phosphatase G6N66_RS04070 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain G6N66_RS04085 ENOG4105CH2 amidohydrolase G6N66_RS04090 ENOG4107RM1 amidohydrolase G6N66_RS04135 ENOG4106EC3 ppe family G6N66_RS04150 ENOG4107QRT dEAD DEAH box helicase G6N66_RS04190 ENOG4108JIK carboxylase G6N66_RS04205 ENOG4107WR6 Maf-like protein G6N66_RS04215 ENOG4105D8K carboxyl transferase G6N66_RS04220 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein G6N66_RS04225 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase G6N66_RS04240 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit G6N66_RS04255 ENOG4105CSH Transporter G6N66_RS04265 ENOG4105BZU Histidine kinase G6N66_RS04290 ENOG410846T CoA-transferase family III G6N66_RS04325 ENOG4107TB5 TRANSCRIPTIONal G6N66_RS04365 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) G6N66_RS04380 ENOG4107QKV phosphomannomutase G6N66_RS04390 ENOG4105EIP mannose-6-phosphate isomerase G6N66_RS04400 ENOG4105CUB amino acid G6N66_RS04405 ENOG4105EEF Alkane 1-monooxygenase G6N66_RS04410 ENOG41084UD rubredoxin G6N66_RS04415 ENOG4105VCQ rubredoxin G6N66_RS04425 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) G6N66_RS04445 ENOG4105G3P Lipoprotein lpqB G6N66_RS04470 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) G6N66_RS04485 ENOG4105EA8 2-Nitropropane dioxygenase G6N66_RS04490 ENOG4105H9W Short-chain dehydrogenase reductase Sdr G6N66_RS04505 ENOG410719E cytochrome p450 G6N66_RS04520 ENOG4107VCP Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) G6N66_RS04525 ENOG4108S7Q sigma 54 modulation protein ribosomal protein S30ea G6N66_RS04530 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving G6N66_RS04535 ENOG4108ESY Metal dependent phosphohydrolase G6N66_RS04545 ENOG4105IDI abc transporter atp-binding protein G6N66_RS04550 ENOG4108SVW integral membrane protein G6N66_RS04580 ENOG4105CSR polyphosphate kinase 2 G6N66_RS04600 ENOG4105H1G trap transporter solute receptor taxi family G6N66_RS04615 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) G6N66_RS04620 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) G6N66_RS04645 ENOG4107RCI amp-dependent synthetase and ligase G6N66_RS04665 ENOG4105CHU acetyl-coa acetyltransferase G6N66_RS04670 ENOG4105KVH Transcriptional regulator G6N66_RS04680 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase G6N66_RS04685 ENOG4108RAV Conserved protein G6N66_RS04725 ENOG4107ZQV short-chain dehydrogenase reductase G6N66_RS04735 ENOG4105CPQ Dehydrogenase G6N66_RS04750 ENOG4105CEY Amp-dependent synthetase and ligase G6N66_RS04755 ENOG4108Z66 YbaK ebsC protein G6N66_RS04760 ENOG4107EXU Short-chain dehydrogenase reductase Sdr G6N66_RS04765 ENOG4105EMN RNA polymerase sigma factor G6N66_RS04775 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit G6N66_RS04790 ENOG4107TE5 Lipid kinase G6N66_RS04810 ENOG4108ZM9 phosphoglycerate mutase G6N66_RS04825 ENOG4105C1J atp-dependent rna helicase G6N66_RS04870 ENOG4108YIQ Alpha beta hydrolase G6N66_RS04915 ENOG4105WBQ Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) G6N66_RS04920 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) G6N66_RS04935 ENOG41063PX domain protein G6N66_RS04975 ENOG4107XVH Transcriptional regulator G6N66_RS04980 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction G6N66_RS04995 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) G6N66_RS05030 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) G6N66_RS05065 ENOG4107TIF Phenazine biosynthesis protein, PhzF family G6N66_RS05085 ENOG4105KNI merR family transcriptional Regulator G6N66_RS05125 ENOG4107XI7 Tetr family transcriptional regulator G6N66_RS05150 ENOG4105CHR reductase G6N66_RS05170 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone G6N66_RS05175 ENOG4108UN4 phage SPO1 DNA polymerase-related protein G6N66_RS05180 ENOG4105CQB FAD linked oxidase domain protein G6N66_RS05185 ENOG4105DIA mandelate racemase muconate lactonizing G6N66_RS05195 ENOG4105EMU Dehydrogenase G6N66_RS05220 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) G6N66_RS05225 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) G6N66_RS05240 ENOG4105CH6 catalase G6N66_RS05245 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) G6N66_RS05255 ENOG4105BZU Histidine kinase G6N66_RS05260 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) G6N66_RS05265 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) G6N66_RS05305 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) G6N66_RS05340 ENOG4105CHR reductase G6N66_RS05360 ENOG4105C7R Atpase associated with various cellular activities aaa_3 G6N66_RS05395 ENOG4105DF2 NADH dehydrogenase subunit j G6N66_RS05410 ENOG4108IEH NADH dehydrogenase subunit g G6N66_RS05470 ENOG4105C1G acyl-Coa dehydrogenase G6N66_RS05485 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G6N66_RS05510 ENOG4107S5I aldo keto reductase G6N66_RS05520 ENOG4105C1G acyl-Coa dehydrogenase G6N66_RS05530 ENOG4107TK4 histidinol-phosphate phosphatase G6N66_RS05600 ENOG4105CQB FAD linked oxidase domain protein G6N66_RS05605 ENOG4105EQH reductase G6N66_RS05615 ENOG4105D8X mechanosensitive ion channel G6N66_RS05625 ENOG4105CAK Cell division ATP-binding protein ftsE G6N66_RS05630 ENOG4107RYD Part of the ABC transporter FtsEX involved in cellular division (By similarity) G6N66_RS05675 ENOG4108JJA ABC, transporter G6N66_RS05700 ENOG4105D9P serine threonine protein kinase G6N66_RS05705 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) G6N66_RS05780 ENOG41060WC Enoyl-CoA hydratase G6N66_RS05790 ENOG4105D2B acyl-CoA dehydrogenase G6N66_RS05795 ENOG4105D2B acyl-CoA dehydrogenase G6N66_RS05800 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) G6N66_RS05810 ENOG4105X7H acyl-CoA dehydrogenase G6N66_RS05825 ENOG4105CHR reductase G6N66_RS05870 ENOG4107GD3 Catalyzes the conversion of acetoacetate to acetone and carbon dioxide (By similarity) G6N66_RS05900 ENOG4107S1E Beta-lactamase G6N66_RS05985 ENOG4105EXG Transcriptional regulator G6N66_RS05990 ENOG4105DVW rieske (2Fe-2S) G6N66_RS06010 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) G6N66_RS06055 ENOG41060BG Tetr family transcriptional regulator G6N66_RS06065 ENOG4105PDP Short chain dehydrogenase G6N66_RS06080 ENOG4105CKW Inner membrane protein yedI G6N66_RS06130 ENOG4105CNG UPF0061 protein G6N66_RS06235 ENOG4108QIU Dehydrogenase G6N66_RS06260 ENOG4105EMU Dehydrogenase G6N66_RS06265 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) G6N66_RS06270 ENOG4105CC9 acyl-Coa dehydrogenase G6N66_RS06275 ENOG4105D2B acyl-CoA dehydrogenase G6N66_RS06280 ENOG4105E39 Enoyl-CoA hydratase G6N66_RS06285 ENOG4105CHR reductase G6N66_RS06290 ENOG4105CEY Amp-dependent synthetase and ligase G6N66_RS06300 ENOG4108IPT Naphthoate synthase G6N66_RS06315 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) G6N66_RS06335 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction G6N66_RS06345 ENOG4105CEY Amp-dependent synthetase and ligase G6N66_RS06350 ENOG410719E cytochrome p450 G6N66_RS06365 ENOG4105X7H acyl-CoA dehydrogenase G6N66_RS06370 ENOG4105CHR reductase G6N66_RS06385 ENOG4105CC9 acyl-Coa dehydrogenase G6N66_RS06390 ENOG4105D2B acyl-CoA dehydrogenase G6N66_RS06400 ENOG4107HY1 Dehydrogenase G6N66_RS06415 ENOG4105CHU acetyl-coa acetyltransferase G6N66_RS06430 ENOG4106A3M Cytochrome p-450 G6N66_RS06455 ENOG4105C26 Dehydrogenase G6N66_RS06475 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr G6N66_RS06495 ENOG4107HY1 Dehydrogenase G6N66_RS06540 ENOG4108V9W transcriptional regulatory protein G6N66_RS06575 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) G6N66_RS06595 ENOG4107GJV short-chain dehydrogenase reductase G6N66_RS06600 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase G6N66_RS06620 ENOG4105BZU Histidine kinase G6N66_RS06630 ENOG4105CI0 Citrate lyase G6N66_RS06635 ENOG4105K6S Short-chain dehydrogenase reductase Sdr G6N66_RS06655 ENOG4105CMR udp-glucose 4-epimerase G6N66_RS06705 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G6N66_RS06720 ENOG4105CHR reductase G6N66_RS06725 ENOG4105CSR polyphosphate kinase 2 G6N66_RS06735 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB G6N66_RS06745 ENOG4105D22 carbon starvation protein G6N66_RS06750 ENOG4107QIM DNA ligase G6N66_RS06760 ENOG4105D2B acyl-CoA dehydrogenase G6N66_RS06775 ENOG4107YCY Transcriptional regulator G6N66_RS06840 ENOG4105EJ2 Transcriptional regulator G6N66_RS06845 ENOG4105F95 Monooxygenase G6N66_RS06850 ENOG4105E1F short-chain dehydrogenase reductase G6N66_RS06870 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) G6N66_RS06920 ENOG4105DKW ABC transporter G6N66_RS06955 ENOG4108V0V Pyrrolo-quinoline quinone G6N66_RS06960 ENOG4105EVB acetyltransferase G6N66_RS06985 ENOG41087PP glycosyltransferase MGT family G6N66_RS07010 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) G6N66_RS07070 ENOG4105C10 Electron transfer flavoprotein G6N66_RS07150 ENOG4105CTQ phosphohexokinase G6N66_RS07160 ENOG4105CHR reductase G6N66_RS07225 ENOG4105C7K acetolactate synthase G6N66_RS07245 ENOG4105CS1 NAD(P)H quinone oxidoreductase G6N66_RS07260 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) G6N66_RS07270 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase G6N66_RS07275 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) G6N66_RS07320 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) G6N66_RS07355 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) G6N66_RS07395 ENOG4105WH1 Two component transcriptional regulator luxr family G6N66_RS07400 ENOG4105BZU Histidine kinase G6N66_RS07425 ENOG4105DP4 dak2 domain fusion protein ylov G6N66_RS07430 ENOG4105CB5 ATP-dependent DNA helicase recG G6N66_RS07460 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) G6N66_RS07465 ENOG4106H78 methyltransferase G6N66_RS07485 ENOG4108M4U conserved membrane protein G6N66_RS07500 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) G6N66_RS07545 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) G6N66_RS07590 ENOG4105DZ1 carboxypeptidase G6N66_RS07620 ENOG4107XUM An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) G6N66_RS07635 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) G6N66_RS07645 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) G6N66_RS07690 ENOG4105DMF Dehydrogenase G6N66_RS07705 ENOG4105RYD Toxic component of a toxin-antitoxin (TA) module. A G6N66_RS07715 ENOG4105CE9 30S ribosomal protein S2 G6N66_RS07725 ENOG4105DV0 amidase (EC 3.5.1.4 G6N66_RS07745 ENOG4107NHD transcriptional regulator G6N66_RS07760 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) G6N66_RS07765 ENOG4105KNE Phosphatidate cytidylyltransferase G6N66_RS07830 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) G6N66_RS07845 ENOG4108Z86 Glutamine amidotransferase G6N66_RS07850 ENOG4105C26 Dehydrogenase G6N66_RS07855 ENOG4105H9W Short-chain dehydrogenase reductase Sdr G6N66_RS07870 ENOG4105D9G High-affinity G6N66_RS07900 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase G6N66_RS07910 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) G6N66_RS07940 ENOG4107Z1I Required for maturation of 30S ribosomal subunits (By similarity) G6N66_RS07955 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) G6N66_RS07965 ENOG4105SFS phosphoesterase RecJ domain protein G6N66_RS07990 ENOG4105E39 Enoyl-CoA hydratase G6N66_RS08035 ENOG4105C1G acyl-Coa dehydrogenase G6N66_RS08055 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) G6N66_RS08065 ENOG4107QWG 2-Nitropropane dioxygenase G6N66_RS08070 ENOG4105DCF alanine dehydrogenase G6N66_RS08185 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) G6N66_RS08240 ENOG4105CEY Amp-dependent synthetase and ligase G6N66_RS08245 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase G6N66_RS08255 ENOG4105CHR reductase G6N66_RS08260 ENOG4105D2B acyl-CoA dehydrogenase G6N66_RS08265 ENOG4105C1G acyl-Coa dehydrogenase G6N66_RS08290 ENOG4105T0Z Conserved Protein G6N66_RS08310 ENOG4105CVR type I restriction-modification system G6N66_RS08325 ENOG4107P7U Inherit from COG: Protein of unknown function (DUF433) G6N66_RS08335 ENOG4105DZR Type I site-specific deoxyribonuclease G6N66_RS08350 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) G6N66_RS08360 ENOG4108UGJ Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) G6N66_RS08410 ENOG4105MXB limonene-12-epoxide hydrolase G6N66_RS08430 ENOG4107KFM Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) G6N66_RS08440 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) G6N66_RS08450 ENOG4105C99 atpase involved in dna repair G6N66_RS08465 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) G6N66_RS08470 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) G6N66_RS08475 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) G6N66_RS08480 ENOG4105C1G acyl-Coa dehydrogenase G6N66_RS08490 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) G6N66_RS08655 ENOG4107VEG TrkA-N domain protein G6N66_RS08660 ENOG4105C0X amino acid G6N66_RS08665 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) G6N66_RS08715 ENOG4105E39 Enoyl-CoA hydratase G6N66_RS08720 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) G6N66_RS08745 ENOG4105E0X reductase G6N66_RS08760 ENOG41084X0 Dihydrofolate reductase G6N66_RS08815 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) G6N66_RS08820 ENOG4105C2D reductase G6N66_RS08990 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) G6N66_RS08995 ENOG4105MP0 transposase G6N66_RS09180 ENOG4108I5C dEAD DEAH box helicase G6N66_RS09410 ENOG4105CHR reductase G6N66_RS09460 ENOG4105C26 Dehydrogenase G6N66_RS09465 ENOG410719E cytochrome p450 G6N66_RS09480 ENOG4106A3M Cytochrome p-450 G6N66_RS09495 ENOG4106A3M Cytochrome p-450 G6N66_RS09525 ENOG41061TZ Short-chain dehydrogenase reductase Sdr G6N66_RS09540 ENOG4107PE3 Mammalian cell entry related domain protein G6N66_RS09570 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) G6N66_RS09600 ENOG4105FAE von Willebrand factor, type A G6N66_RS09660 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr G6N66_RS09675 ENOG4105DTD Dehydrogenase G6N66_RS09695 ENOG4105XEA Tetr family transcriptional regulator G6N66_RS09705 ENOG4108UGJ Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) G6N66_RS09710 ENOG4105MKU Transcriptional regulator G6N66_RS09765 ENOG4105CHU acetyl-coa acetyltransferase G6N66_RS09800 ENOG4108IPT Naphthoate synthase G6N66_RS09840 ENOG4105CHR reductase G6N66_RS09845 ENOG4107VGR Catalase G6N66_RS09850 ENOG4106PVI ATP-dependent carboxylate-amine ligase (By similarity) G6N66_RS09890 ENOG4105FB2 class II Aldolase G6N66_RS09895 ENOG4108QJ2 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase G6N66_RS09940 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase G6N66_RS10000 ENOG4107S5I aldo keto reductase G6N66_RS10020 ENOG4105C22 threonyL-tRNA synthetase G6N66_RS10040 ENOG4105E2K Glycosyl transferase (Group 1 G6N66_RS10045 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) G6N66_RS10060 ENOG4105C29 acyl-CoA thioesterase G6N66_RS10160 ENOG4105E4E Thioester reductase domain-containing protein G6N66_RS10165 ENOG4108JPW Aminotransferase G6N66_RS10180 ENOG4107RTU Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) G6N66_RS10185 ENOG4108NY6 Extracellular solute-binding protein, family 5 G6N66_RS10200 ENOG4108ZR3 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity) G6N66_RS10205 ENOG4107VMB Beta-lactamase domain protein G6N66_RS10240 ENOG4107W7X Aldolase G6N66_RS10245 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) G6N66_RS10325 ENOG4107ZED Uncharacterised protein family UPF0047 G6N66_RS10330 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) G6N66_RS10380 ENOG4105DC7 peptidase M24 G6N66_RS10430 ENOG4108IYU L-aspartate oxidase G6N66_RS10435 ENOG4105D9U N-acetyltransferase G6N66_RS10450 ENOG4108YRB methyltransferase G6N66_RS10455 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) G6N66_RS10460 ENOG4105CXT aspartate transcarbamylase G6N66_RS10475 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain G6N66_RS10485 ENOG4105SKN orotidine 5''-phosphate decarboxylase G6N66_RS10510 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP G6N66_RS10525 ENOG4107RN6 Monooxygenase G6N66_RS10585 ENOG41064B9 (LipO)protein G6N66_RS10625 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) G6N66_RS10650 ENOG4105EBR Carboxylesterase G6N66_RS10655 ENOG4105CEY Amp-dependent synthetase and ligase G6N66_RS10695 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase G6N66_RS10700 ENOG4105BZA Phosphoglycerate kinase G6N66_RS10760 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) G6N66_RS10775 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein G6N66_RS10800 ENOG4107JC6 Membrane G6N66_RS10820 ENOG4105C3K feS assembly ATPase SufC G6N66_RS10825 ENOG4105C9B Cysteine desulfurase G6N66_RS10830 ENOG4108UNV SUF system FeS assembly protein, NifU family G6N66_RS10835 ENOG4105VG1 fes assembly suf system protein G6N66_RS10850 ENOG4105CSU acyl-Coa dehydrogenase G6N66_RS10855 ENOG41080RH Thioredoxin G6N66_RS10865 ENOG4105C5H ABC transporter G6N66_RS10870 ENOG4108Q5F Tetr family transcriptional regulator G6N66_RS10875 ENOG4107QM5 aconitate hydratase G6N66_RS10885 ENOG4105ZXU NLP P60 protein G6N66_RS10895 ENOG4105C7R Atpase associated with various cellular activities aaa_3 G6N66_RS10905 ENOG4107QVM von Willebrand factor, type A G6N66_RS10915 ENOG4105CHR reductase G6N66_RS10920 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH G6N66_RS11050 ENOG4108YRB methyltransferase G6N66_RS11070 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) G6N66_RS11090 ENOG4105HDK L-asparaginase G6N66_RS11110 ENOG4105K6B K06886 hemoglobin G6N66_RS11120 ENOG4108W6C Dehydrogenase G6N66_RS11155 ENOG4105CSW GntR family transcriptional regulator G6N66_RS11205 ENOG4105ZXU NLP P60 protein G6N66_RS11265 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) G6N66_RS11275 ENOG4105C6Y Udp-glucose 6-dehydrogenase G6N66_RS11305 ENOG4107EMZ glycosyl transferase family G6N66_RS11325 ENOG4105EXC Acyl-transferase G6N66_RS11330 ENOG4105C30 Nad-dependent epimerase dehydratase G6N66_RS11335 ENOG4105C0K Gdp-mannose 4,6-dehydratase G6N66_RS11375 ENOG4105C6Y Udp-glucose 6-dehydrogenase G6N66_RS11380 ENOG4108I2E Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto- arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4- amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido- arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) G6N66_RS11385 ENOG4105EXC Acyl-transferase G6N66_RS11400 ENOG4105EXC Acyl-transferase G6N66_RS11410 ENOG4107EMZ glycosyl transferase family G6N66_RS11425 ENOG4108JA1 polyketide synthase G6N66_RS11435 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family G6N66_RS11450 ENOG4105CEY Amp-dependent synthetase and ligase G6N66_RS11495 ENOG4105CV8 reductase G6N66_RS11525 ENOG41066NP positive regulation by symbiont of host immune response G6N66_RS11570 ENOG4105J7D transcriptional regulator G6N66_RS11610 ENOG4108MWI inositol mono-phosphatase G6N66_RS11645 ENOG4105CRQ synthase (Component I) G6N66_RS11685 ENOG4105C29 acyl-CoA thioesterase G6N66_RS11700 ENOG4108JJ9 ABC, transporter G6N66_RS11705 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii G6N66_RS11710 ENOG4105C4M (Ubiquinol oxidase) subunit I G6N66_RS11805 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) G6N66_RS11815 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) G6N66_RS11820 ENOG4105DQE DNA ligase G6N66_RS11825 ENOG4105DQE DNA ligase G6N66_RS11830 ENOG4105DQE DNA ligase G6N66_RS11845 ENOG4105IDI abc transporter atp-binding protein G6N66_RS11870 ENOG4105KT7 mgtC SapB transporter G6N66_RS11895 ENOG4105C5X domain protein G6N66_RS11935 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) G6N66_RS11965 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) G6N66_RS11970 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) G6N66_RS11990 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase G6N66_RS11995 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) G6N66_RS12035 ENOG4108JA1 polyketide synthase G6N66_RS12040 ENOG4108JA1 polyketide synthase G6N66_RS12045 ENOG4108JA1 polyketide synthase G6N66_RS12045 ENOG4108JA1 polyketide synthase G6N66_RS12060 ENOG4105C5H ABC transporter G6N66_RS12075 ENOG4105W49 UPF0434 protein G6N66_RS12090 ENOG4105CJ1 ABC, transporter G6N66_RS12125 ENOG4105DSU hydrolase G6N66_RS12195 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) G6N66_RS12205 ENOG4105CAT Cytidine monophosphate kinase G6N66_RS12210 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) G6N66_RS12230 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) G6N66_RS12315 ENOG4107SM8 Adenylate Guanylate cyclase G6N66_RS12325 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) G6N66_RS12355 ENOG4105CPQ Dehydrogenase G6N66_RS12390 ENOG4105C26 Dehydrogenase G6N66_RS12455 ENOG4107R13 MMPL domain protein G6N66_RS12460 ENOG4105C54 Major Facilitator superfamily G6N66_RS12465 ENOG4105X1P Steroid delta-isomerase G6N66_RS12490 ENOG4105D9P serine threonine protein kinase G6N66_RS12540 ENOG4105WH1 Two component transcriptional regulator luxr family G6N66_RS12545 ENOG4105WH1 Two component transcriptional regulator luxr family G6N66_RS12580 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) G6N66_RS12620 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) G6N66_RS12625 ENOG4108Z6Z Transcriptional regulator G6N66_RS12630 ENOG4105CHR reductase G6N66_RS12635 ENOG4107QY8 reductase G6N66_RS12650 ENOG4105IDI abc transporter atp-binding protein G6N66_RS12655 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr G6N66_RS12675 ENOG4108IG5 Transcriptional regulator G6N66_RS12700 ENOG4105C1G acyl-Coa dehydrogenase G6N66_RS12705 ENOG4105CHR reductase G6N66_RS12715 ENOG410900P UPF0336 protein G6N66_RS12720 ENOG4105CEY Amp-dependent synthetase and ligase G6N66_RS12745 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) G6N66_RS12750 ENOG4107SFI Major Facilitator superfamily G6N66_RS12780 ENOG41076PI Short-chain dehydrogenase reductase Sdr G6N66_RS12795 ENOG4105EMU Dehydrogenase G6N66_RS12850 ENOG4105CHR reductase G6N66_RS12875 ENOG41061H0 Monooxygenase G6N66_RS12885 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) G6N66_RS12895 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) G6N66_RS12900 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) G6N66_RS12920 ENOG4105K8R UPF0145 protein G6N66_RS12960 ENOG4106S2D Transcriptional regulator G6N66_RS12965 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) G6N66_RS12970 ENOG4105C1G acyl-Coa dehydrogenase G6N66_RS12975 ENOG4105E39 Enoyl-CoA hydratase G6N66_RS12980 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein G6N66_RS13005 ENOG4105CPP Dehydrogenase, E1 component G6N66_RS13010 ENOG4107RUY (E1 component), alpha subunit G6N66_RS13015 ENOG41076PI Short-chain dehydrogenase reductase Sdr G6N66_RS13020 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G6N66_RS13040 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) G6N66_RS13265 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein G6N66_RS13355 ENOG4107UAX integral membrane protein G6N66_RS13360 ENOG4105C37 (CBS) domain G6N66_RS13370 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) G6N66_RS13390 ENOG4105CEP NADH dehydrogenase G6N66_RS13395 ENOG4105EQP Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate (By similarity) G6N66_RS13460 ENOG4105EMU Dehydrogenase G6N66_RS13465 ENOG4107S2E monooxygenase G6N66_RS13495 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) G6N66_RS13505 ENOG4105CHU acetyl-coa acetyltransferase G6N66_RS13535 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) G6N66_RS13565 ENOG4108X7C Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) G6N66_RS13575 ENOG4105C5Q Transcriptional regulator G6N66_RS13590 ENOG4108UKI Enoyl-CoA hydratase G6N66_RS13600 ENOG4108UQY Iron-storage protein G6N66_RS13615 ENOG4105C5F glutamine synthetase G6N66_RS13640 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) G6N66_RS13650 ENOG4107YCR Transcriptional regulator, ARSR family G6N66_RS13685 ENOG4105CHR reductase G6N66_RS13770 ENOG4105E2A Dehydrogenase G6N66_RS13815 ENOG4107RGD Major Facilitator superfamily G6N66_RS13825 ENOG41082T9 Membrane G6N66_RS13830 ENOG4105E39 Enoyl-CoA hydratase G6N66_RS13870 ENOG4105CEY Amp-dependent synthetase and ligase G6N66_RS13880 ENOG4105EA8 2-Nitropropane dioxygenase G6N66_RS13885 ENOG41090U3 tautomerase G6N66_RS13890 ENOG4108KB2 LysR family Transcriptional regulator G6N66_RS13940 ENOG4105MHT Transcriptional regulator, ARSR family G6N66_RS13990 ENOG4105CRW Short chain fatty acid transporter G6N66_RS13995 ENOG4107RCI amp-dependent synthetase and ligase G6N66_RS14045 ENOG4105F9F transposase G6N66_RS14050 ENOG4105CEY Amp-dependent synthetase and ligase G6N66_RS14055 ENOG4105D2B acyl-CoA dehydrogenase G6N66_RS14060 ENOG4105CC9 acyl-Coa dehydrogenase G6N66_RS14075 ENOG4105F57 Anthranilate dioxygenase reductase G6N66_RS14085 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) G6N66_RS14110 ENOG4105C26 Dehydrogenase G6N66_RS14115 ENOG4105WH1 Two component transcriptional regulator luxr family G6N66_RS14120 ENOG4106A3M Cytochrome p-450 G6N66_RS14205 ENOG4105D74 hydrolase G6N66_RS14235 ENOG4105C0A alcohol dehydrogenase G6N66_RS14250 ENOG4105C85 amino acid G6N66_RS14270 ENOG4108XW1 Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) G6N66_RS14285 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) G6N66_RS14290 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) G6N66_RS14305 ENOG4105D2B acyl-CoA dehydrogenase G6N66_RS14310 ENOG4105D2B acyl-CoA dehydrogenase G6N66_RS14325 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) G6N66_RS14330 ENOG4108R85 Short chain dehydrogenase G6N66_RS14345 ENOG4108RZE Tetr family transcriptional regulator G6N66_RS14390 ENOG4107UBC ErfK ybiS ycfS ynhG family protein G6N66_RS14400 ENOG4108UDB Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) G6N66_RS14405 ENOG4108NUI synthase G6N66_RS14430 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes G6N66_RS14465 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase G6N66_RS14475 ENOG4105BZU Histidine kinase G6N66_RS14480 ENOG4105CQ7 ATP-dependent helicase G6N66_RS14510 ENOG4107QKG PfaD family G6N66_RS14515 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate G6N66_RS14525 ENOG4108V1T peptidylprolyl cis-trans isomerase G6N66_RS14550 ENOG4105BZU Histidine kinase G6N66_RS14585 ENOG4108WKN secreted protein G6N66_RS14655 ENOG4105K6V RNA polymerase G6N66_RS14660 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) G6N66_RS14675 ENOG4105CIG ABC transporter G6N66_RS14725 ENOG4105D2B acyl-CoA dehydrogenase G6N66_RS14745 ENOG4105CB2 alcohol dehydrogenase G6N66_RS14750 ENOG4105E39 Enoyl-CoA hydratase G6N66_RS14785 ENOG4105DBE peroxidase G6N66_RS14790 ENOG410650H (LipO)protein G6N66_RS14795 ENOG4105EKT )-iron permease G6N66_RS14815 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component G6N66_RS14820 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component G6N66_RS14830 ENOG4108KPJ rna polymerase sigma factor G6N66_RS14845 ENOG4108RWI nicotinamidase G6N66_RS14855 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family G6N66_RS14865 ENOG4105EBR Carboxylesterase G6N66_RS14875 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr G6N66_RS14895 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) G6N66_RS14900 ENOG41076PI Short-chain dehydrogenase reductase Sdr G6N66_RS14970 ENOG4105GMT ATPase associated with various cellular activities aaa_5 G6N66_RS15005 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr G6N66_RS15105 ENOG4105CTK cobaltochelatase, cobn subunit G6N66_RS15175 ENOG4108RG3 short-chain dehydrogenase reductase G6N66_RS15190 ENOG4105ETX regulatoR G6N66_RS15195 ENOG4106F60 Histidine kinase G6N66_RS15250 ENOG4107TMB Transcriptional regulator G6N66_RS15325 ENOG4107QN2 dihydrolipoyl dehydrogenase G6N66_RS15405 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) G6N66_RS15420 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) G6N66_RS15485 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) G6N66_RS15500 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) G6N66_RS15525 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) G6N66_RS15530 ENOG4105CJN penicillin-binding protein G6N66_RS15560 ENOG4105R14 (LipO)protein G6N66_RS15575 ENOG41090CE integral membrane protein G6N66_RS15580 ENOG4105KYH transcriptional regulatory protein G6N66_RS15595 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase G6N66_RS15625 ENOG4105D0U Arsenite-activated ATPase (ArsA) G6N66_RS15640 ENOG4108IQE Amp-dependent synthetase and ligase G6N66_RS15675 ENOG4105CCU oxidase (Subunit III) G6N66_RS15680 ENOG4107UDY cytochrome C G6N66_RS15715 ENOG4108ZRS Part of cytochrome c oxidase, its function is G6N66_RS15730 ENOG4107T4Z adenosine kinase G6N66_RS15785 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) G6N66_RS15830 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) G6N66_RS15860 ENOG4105WEF catalase G6N66_RS15915 ENOG4105BZU Histidine kinase G6N66_RS15920 ENOG4105WH1 Two component transcriptional regulator luxr family G6N66_RS15925 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) G6N66_RS15955 ENOG4107QPD alcohol dehydrogenase G6N66_RS15960 ENOG4105C26 Dehydrogenase G6N66_RS15990 ENOG4106A3M Cytochrome p-450 G6N66_RS16045 ENOG41061TZ Short-chain dehydrogenase reductase Sdr G6N66_RS16055 ENOG4105CIR epoxide hydrolase G6N66_RS16125 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) G6N66_RS16200 ENOG4105PDP Short chain dehydrogenase G6N66_RS16260 ENOG4108RU2 n-acetylmuramoyl-l-alanine amidase G6N66_RS16310 ENOG4106A3M Cytochrome p-450 G6N66_RS16370 ENOG41061TZ Short-chain dehydrogenase reductase Sdr G6N66_RS16385 ENOG4105CEY Amp-dependent synthetase and ligase G6N66_RS16490 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) G6N66_RS16565 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) G6N66_RS16620 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving G6N66_RS16625 ENOG4105KAK Plasmid pRiA4b ORF-3 family protein G6N66_RS16700 ENOG4108MJN Glycosyl Transferase G6N66_RS16725 ENOG4105D74 hydrolase G6N66_RS16750 ENOG4108M8W Monooxygenase G6N66_RS16755 ENOG4105C87 Aminotransferase class I and II G6N66_RS16760 ENOG4105CPT Alpha beta hydrolase G6N66_RS16810 ENOG4105PP6 Membrane G6N66_RS16840 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 G6N66_RS16860 ENOG4105CEY Amp-dependent synthetase and ligase G6N66_RS16875 ENOG4108RM3 Phosphatase with a broad specificity. Its primary physiological function is to dephosphorylate 3'-phosphoadenosine 5'-phosphate (PAP) and 3'-phosphoadenosine 5'-phosphosulfate (PAPS). Thus, plays a role in mycobacterial sulfur metabolism, since it can serve as a key regulator of the sulfate assimilation pathway by controlling the pools of PAP and PAPS in the cell. To a lesser extent, is also able to hydrolyze inositol 1-phosphate (I- 1-P), fructose 1,6-bisphosphate (FBP) (to fructose 6-phosphate (F- 6-P)) and AMP in vitro, but this might has no significance in vivo G6N66_RS16895 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) G6N66_RS16900 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) G6N66_RS16905 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase G6N66_RS16935 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) G6N66_RS16970 ENOG41069FZ L,D-transpeptidase catalytic domain G6N66_RS16975 ENOG4105CSH Transporter G6N66_RS17020 ENOG4105K5B UPF0225 protein G6N66_RS17040 ENOG4105FBN Acid phosphatase G6N66_RS17065 ENOG4105E39 Enoyl-CoA hydratase G6N66_RS17135 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component G6N66_RS17155 ENOG4105CUB amino acid G6N66_RS17160 ENOG4105C8Y Acetylornithine aminotransferase G6N66_RS17165 ENOG4105CIK Amidinotransferase G6N66_RS17170 ENOG4105F7P transcriptional regulator AsnC family G6N66_RS17195 ENOG4105IDI abc transporter atp-binding protein G6N66_RS17215 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) G6N66_RS17220 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) G6N66_RS17240 ENOG4108SNK aliphatic sulfonates import ATP-binding protein SsuB G6N66_RS17245 ENOG4105I5W Transporter G6N66_RS17250 ENOG4105DG7 nitrate ABC transporter G6N66_RS17320 ENOG4107ZR7 Membrane G6N66_RS17330 ENOG4105D7W serine acetyltransferase G6N66_RS17390 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) G6N66_RS17395 ENOG4105H08 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) G6N66_RS17445 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) G6N66_RS17470 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) G6N66_RS17480 ENOG4105ECQ AraC Family Transcriptional Regulator G6N66_RS17495 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) G6N66_RS17525 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) G6N66_RS17560 ENOG4105C0W non-ribosomal peptide synthetase G6N66_RS17570 ENOG4105CEY Amp-dependent synthetase and ligase G6N66_RS17575 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) G6N66_RS17590 ENOG4107SQU synthase G6N66_RS17600 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase G6N66_RS17625 ENOG4107RN6 Monooxygenase G6N66_RS17680 ENOG4105ECW sulfate abc transporter G6N66_RS17685 ENOG4108I5D sulfate abc transporter G6N66_RS17690 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein G6N66_RS17700 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) G6N66_RS17705 ENOG4105BZP glycoside hydrolase 15-related G6N66_RS17730 ENOG4107XDQ Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) G6N66_RS17780 ENOG4105KQC Competence protein G6N66_RS17785 ENOG4105CC9 acyl-Coa dehydrogenase G6N66_RS17815 ENOG4107RCI amp-dependent synthetase and ligase G6N66_RS17845 ENOG4108TZC G6N66_RS17855 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) G6N66_RS17860 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) G6N66_RS17875 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit G6N66_RS17880 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) G6N66_RS17885 ENOG4105D8X mechanosensitive ion channel G6N66_RS17890 ENOG4105BZU Histidine kinase G6N66_RS17895 ENOG4108RVA ribokinase G6N66_RS17910 ENOG4108DWA Nad synthetase G6N66_RS17935 ENOG4105K56 Transcriptional regulator G6N66_RS17950 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control G6N66_RS17985 ENOG4105C03 ribonuclease G6N66_RS17990 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) G6N66_RS18000 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase G6N66_RS18020 ENOG4105EG6 Saccharopine dehydrogenase G6N66_RS18035 ENOG41080AZ Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) G6N66_RS18040 ENOG4105DQU oxidoreductase, subunit beta G6N66_RS18045 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein G6N66_RS18050 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) G6N66_RS18055 ENOG4107QK5 Homocysteine s-methyltransferase G6N66_RS18060 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) G6N66_RS18065 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) G6N66_RS18100 ENOG4105MC2 DSBA oxidoreductase G6N66_RS18130 ENOG4108Z18 K06886 hemoglobin G6N66_RS18135 ENOG4105CG3 alpha amylase, catalytic region G6N66_RS18155 ENOG4105C7I Dehydrogenase G6N66_RS18180 ENOG4105EAC phosphoserine phosphatase G6N66_RS18200 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) G6N66_RS18245 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) G6N66_RS18310 ENOG4105DNP FAD linked oxidase domain protein G6N66_RS18340 ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 G6N66_RS18360 ENOG4105DJG MaoC domain protein dehydratase G6N66_RS18365 ENOG4105C1G acyl-Coa dehydrogenase G6N66_RS18375 ENOG4107QX3 carboxylase G6N66_RS18405 ENOG4105E1F short-chain dehydrogenase reductase G6N66_RS18410 ENOG4105D7A ATP-binding protein G6N66_RS18430 ENOG4107UBC ErfK ybiS ycfS ynhG family protein G6N66_RS18480 ENOG4105WH1 Two component transcriptional regulator luxr family G6N66_RS18505 ENOG4108WKN secreted protein G6N66_RS18510 ENOG4105FUY alpha subunit G6N66_RS18545 ENOG4105CEY Amp-dependent synthetase and ligase G6N66_RS18585 ENOG4105C1G acyl-Coa dehydrogenase G6N66_RS18590 ENOG4105D2B acyl-CoA dehydrogenase G6N66_RS18595 ENOG4105CC9 acyl-Coa dehydrogenase G6N66_RS18600 ENOG4105C1G acyl-Coa dehydrogenase G6N66_RS18605 ENOG4105CEY Amp-dependent synthetase and ligase G6N66_RS18635 ENOG4105D2B acyl-CoA dehydrogenase G6N66_RS18640 ENOG4105D2B acyl-CoA dehydrogenase G6N66_RS18675 ENOG4105Q56 cytochrome P450 G6N66_RS18715 ENOG4107QX3 carboxylase G6N66_RS18720 ENOG4108IG5 Transcriptional regulator G6N66_RS18735 ENOG4105GMT ATPase associated with various cellular activities aaa_5 G6N66_RS18745 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase G6N66_RS18765 ENOG4107S2E monooxygenase G6N66_RS18770 ENOG4108K3M Rieske [2Fe-2S] domain G6N66_RS18810 ENOG4105X7H acyl-CoA dehydrogenase G6N66_RS18855 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) G6N66_RS18880 ENOG4105CGU Enoyl-CoA hydratase G6N66_RS18885 ENOG4105E39 Enoyl-CoA hydratase G6N66_RS18890 ENOG4108UKI Enoyl-CoA hydratase G6N66_RS18900 ENOG4105CEY Amp-dependent synthetase and ligase G6N66_RS18905 ENOG4105CEY Amp-dependent synthetase and ligase G6N66_RS18910 ENOG4108WYP Transcriptional regulator G6N66_RS18915 ENOG4105C1G acyl-Coa dehydrogenase G6N66_RS18920 ENOG4105IYB L-carnitine dehydratase bile acid-inducible protein F G6N66_RS18925 ENOG4105CHU acetyl-coa acetyltransferase G6N66_RS18935 ENOG4105C1G acyl-Coa dehydrogenase G6N66_RS18970 ENOG4105WX6 Membrane G6N66_RS18985 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) G6N66_RS18995 ENOG4108RQ5 Beta-lactamase domain-containing protein G6N66_RS19025 ENOG4107RKP Nicotinate phosphoribosyltransferase G6N66_RS19045 ENOG4108IUN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) G6N66_RS19055 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) G6N66_RS19095 ENOG4105D94 Major Facilitator Superfamily G6N66_RS19100 ENOG4107RSM transcriptional regulator G6N66_RS19140 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) G6N66_RS19175 ENOG4108T62 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) G6N66_RS19185 ENOG410679R F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) G6N66_RS19190 ENOG4107RAZ it plays a direct role in the translocation of protons across the membrane (By similarity) G6N66_RS19210 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) G6N66_RS19225 ENOG4105J5T Amp-dependent synthetase and ligase G6N66_RS19245 ENOG4105D6E homoserine dehydrogenase G6N66_RS19250 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) G6N66_RS19255 ENOG4105C75 arginyL-tRNA synthetase G6N66_RS19295 ENOG4105CHR reductase G6N66_RS19305 ENOG41060BG Tetr family transcriptional regulator G6N66_RS19325 ENOG4108M8W Monooxygenase G6N66_RS19490 ENOG4105BZU Histidine kinase G6N66_RS19495 ENOG4105DEN Luciferase family G6N66_RS19515 ENOG4105CQB FAD linked oxidase domain protein G6N66_RS19555 ENOG41072EW lipoprotein LprE G6N66_RS19630 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 G6N66_RS19660 ENOG4105D9Z Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) G6N66_RS19665 ENOG4105D7N magnesium and cobalt transport protein CorA G6N66_RS19705 ENOG4105CJW magnesium transporter G6N66_RS19725 ENOG4105VG9 Plasmid stabilization system G6N66_RS19730 ENOG41067D0 Antitoxin component of a toxin-antitoxin (TA) module. Upon expression in M.smegmatis neutralizes the effect of toxin RelE2 G6N66_RS19750 ENOG4106WTF Glycosyl transferase, family 2 G6N66_RS19840 ENOG4105C0H protease G6N66_RS19845 ENOG4106684 G6N66_RS19870 ENOG4108X07 Tetr family transcriptional regulator G6N66_RS19875 ENOG4105CIG ABC transporter G6N66_RS19880 ENOG4105DIM ABC transporter G6N66_RS19890 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase G6N66_RS19905 ENOG4105FAW cDP-glucose 4,6-dehydratase G6N66_RS19930 ENOG4107XZA Glycosyl transferase family 2 G6N66_RS19935 ENOG4105DZ1 carboxypeptidase G6N66_RS19980 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) G6N66_RS19990 ENOG4105C3Q Glycosyl transferase, family 2 G6N66_RS20005 ENOG4108URH decarboxylase G6N66_RS20020 ENOG41060JE PilT protein domain protein G6N66_RS20070 ENOG4105CSH Transporter G6N66_RS20075 ENOG4105CEY Amp-dependent synthetase and ligase G6N66_RS20095 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G6N66_RS20105 ENOG410719E cytochrome p450 G6N66_RS20110 ENOG4105X7H acyl-CoA dehydrogenase G6N66_RS20125 ENOG4108KC2 acyl-Coa dehydrogenase G6N66_RS20155 ENOG4105E39 Enoyl-CoA hydratase G6N66_RS20165 ENOG4105C26 Dehydrogenase G6N66_RS20180 ENOG4105C26 Dehydrogenase G6N66_RS20185 ENOG4108K8K Transcriptional regulator G6N66_RS20200 ENOG4107QJG Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) G6N66_RS20220 ENOG4105C0X amino acid G6N66_RS20230 ENOG4108Z4U Ferredoxin G6N66_RS20260 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) G6N66_RS20290 ENOG4108IUE nitrate reductase beta subunit G6N66_RS20335 ENOG4105D74 hydrolase G6N66_RS20345 ENOG4105F95 Monooxygenase G6N66_RS20460 ENOG410905P Pyridoxamine 5-phosphate G6N66_RS20500 ENOG4107R13 MMPL domain protein G6N66_RS20510 ENOG410846T CoA-transferase family III G6N66_RS20515 ENOG4108UKI Enoyl-CoA hydratase G6N66_RS20520 ENOG4105CGD Nad-dependent epimerase dehydratase G6N66_RS20530 ENOG4105CGD Nad-dependent epimerase dehydratase G6N66_RS20535 ENOG4108Z0R Transferase G6N66_RS20570 ENOG4105C26 Dehydrogenase G6N66_RS20575 ENOG4106A3M Cytochrome p-450 G6N66_RS20610 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr G6N66_RS20615 ENOG4105CC9 acyl-Coa dehydrogenase G6N66_RS20620 ENOG4105D2B acyl-CoA dehydrogenase G6N66_RS20630 ENOG4108RZE Tetr family transcriptional regulator G6N66_RS20710 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) G6N66_RS20725 ENOG4108J2P Alpha beta hydrolase fold G6N66_RS20770 ENOG4108J5G 6-phosphogluconate dehydrogenase G6N66_RS20790 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase G6N66_RS20840 ENOG41067D0 Antitoxin component of a toxin-antitoxin (TA) module. Upon expression in M.smegmatis neutralizes the effect of toxin RelE2 G6N66_RS20845 ENOG4105C3G gtp-binding protein G6N66_RS20855 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) G6N66_RS20935 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) G6N66_RS20950 ENOG4105EBR Carboxylesterase G6N66_RS20990 ENOG4108IAB Phoh family G6N66_RS21000 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) G6N66_RS21005 ENOG4105CS9 pantothenic acid kinase G6N66_RS21020 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) G6N66_RS21030 ENOG4105C7Z Conserved Protein G6N66_RS21060 ENOG4105W8D rdd domain containing protein G6N66_RS21080 ENOG4105CHU acetyl-coa acetyltransferase G6N66_RS21090 ENOG4108UKI Enoyl-CoA hydratase G6N66_RS21240 ENOG4105CK6 Two component transcriptional regulator (Winged helix family G6N66_RS21245 ENOG4105BZU Histidine kinase G6N66_RS21260 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) G6N66_RS21265 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) G6N66_RS21310 ENOG4105DXN mazG family G6N66_RS21375 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) G6N66_RS21390 ENOG4107RCI amp-dependent synthetase and ligase G6N66_RS21410 ENOG4105F8V Hydrolase, tatD family G6N66_RS21430 ENOG41064MX Tetr family transcriptional regulator G6N66_RS21450 ENOG4108DNI pyridine nucleotide-disulfide oxidoreductase G6N66_RS21455 ENOG4108KPJ rna polymerase sigma factor G6N66_RS21460 ENOG4105CRQ synthase (Component I) G6N66_RS21505 ENOG410870F Cyclic nucleotide-binding protein G6N66_RS21585 ENOG4105KRP Plasmid stabilization system G6N66_RS21595 ENOG4105CAF HipA N-terminal domain protein G6N66_RS21670 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase G6N66_RS21675 ENOG41080UU 5-formyltetrahydrofolate cyclo-ligase G6N66_RS21695 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) G6N66_RS21715 ENOG41067C8 50S ribosomal protein L32 G6N66_RS21735 ENOG4107QX3 carboxylase G6N66_RS21750 ENOG41060WC Enoyl-CoA hydratase G6N66_RS21785 ENOG41078VV 34 kDa antigenic protein G6N66_RS21815 ENOG4105DR5 peptidase G6N66_RS21900 ENOG4105ERH Fumarylacetoacetate hydrolase G6N66_RS21910 ENOG4105CQB FAD linked oxidase domain protein G6N66_RS21940 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) G6N66_RS21950 ENOG4105DEI Mannitol dehydrogenase G6N66_RS21960 ENOG4105DEI Mannitol dehydrogenase G6N66_RS21965 ENOG4105D7K pfkb domain protein G6N66_RS21975 ENOG4105E2Z phosphate ABC transporter (Permease G6N66_RS21985 ENOG4107QJG Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) G6N66_RS21990 ENOG4107QJG Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) G6N66_RS22005 ENOG4105CHR reductase G6N66_RS22130 ENOG4105DJ4 phosphatidylserine decarboxylase G6N66_RS22135 ENOG4107MVR Transcriptional regulator G6N66_RS22140 ENOG4107SCK Monooxygenase G6N66_RS22150 ENOG4105E2K Glycosyl transferase (Group 1 G6N66_RS22205 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) G6N66_RS22230 ENOG4107R8H Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) G6N66_RS22250 ENOG4105XMC MarR family Transcriptional regulator G6N66_RS22265 ENOG4108N0W Major Facilitator superfamily G6N66_RS22280 ENOG4105CHF Glutathione S-transferase G6N66_RS22290 ENOG4105VEQ Cold shock protein G6N66_RS22315 ENOG4105EPU Molybdenum cofactor synthesis domain protein G6N66_RS22335 ENOG4105CFI type iii restriction protein res subunit G6N66_RS22340 ENOG4105CHU acetyl-coa acetyltransferase G6N66_RS22355 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) G6N66_RS22385 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase G6N66_RS22390 ENOG4105CHU acetyl-coa acetyltransferase G6N66_RS22415 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G6N66_RS22425 ENOG4107RA9 decarboxylase G6N66_RS22440 ENOG4105CEY Amp-dependent synthetase and ligase G6N66_RS22455 ENOG4105E39 Enoyl-CoA hydratase G6N66_RS22530 ENOG4105CY3 ABC transporter, permease G6N66_RS22535 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G6N66_RS22540 ENOG4105CHR reductase G6N66_RS22570 ENOG4105CC9 acyl-Coa dehydrogenase G6N66_RS22575 ENOG4105D2B acyl-CoA dehydrogenase G6N66_RS22580 ENOG4105HMD G6N66_RS22585 ENOG4105CMR udp-glucose 4-epimerase G6N66_RS22595 ENOG41088YA Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives (By similarity) G6N66_RS22600 ENOG4105C1G acyl-Coa dehydrogenase G6N66_RS22605 ENOG41061TZ Short-chain dehydrogenase reductase Sdr G6N66_RS22615 ENOG4105C26 Dehydrogenase G6N66_RS22620 ENOG4105DVW rieske (2Fe-2S) G6N66_RS22690 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase G6N66_RS22745 ENOG4105GMT ATPase associated with various cellular activities aaa_5 G6N66_RS22775 ENOG4105ES1 acyl-CoA reductase G6N66_RS22785 ENOG4105C26 Dehydrogenase G6N66_RS22790 ENOG4105CEY Amp-dependent synthetase and ligase G6N66_RS22805 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase G6N66_RS22835 ENOG4107EEP NADH dehydrogenase (quinone) (EC 1.6.99.5) G6N66_RS22845 ENOG4105CC9 acyl-Coa dehydrogenase G6N66_RS22880 ENOG4106A3M Cytochrome p-450 G6N66_RS22910 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) G6N66_RS22915 ENOG4105CHU acetyl-coa acetyltransferase G6N66_RS22920 ENOG4105CGU Enoyl-CoA hydratase G6N66_RS22940 ENOG4105DVW rieske (2Fe-2S) G6N66_RS22950 ENOG4105CPN adenine deaminase G6N66_RS22960 ENOG4105CC9 acyl-Coa dehydrogenase G6N66_RS22965 ENOG4105D2B acyl-CoA dehydrogenase G6N66_RS22975 ENOG4105CC9 acyl-Coa dehydrogenase G6N66_RS22990 ENOG41076PI Short-chain dehydrogenase reductase Sdr G6N66_RS23000 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G6N66_RS23050 ENOG4107R16 Multicopper oxidase G6N66_RS23065 ENOG4105CHR reductase G6N66_RS23075 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein G6N66_RS23080 ENOG4105MI0 Catalyzes the non-heme iron(II)-dependent oxidative cleavage of 2,3-dihydroxyphenylpropionic acid and 2,3- dihydroxicinnamic acid into 2-hydroxy-6-ketononadienedioate and 2- hydroxy-6-ketononatrienedioate, respectively (By similarity) G6N66_RS23100 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein G6N66_RS23110 ENOG4105CHU acetyl-coa acetyltransferase G6N66_RS23115 ENOG4107WD4 Releases the N-terminal proline from various substrates (By similarity) G6N66_RS23145 ENOG4105CC9 acyl-Coa dehydrogenase G6N66_RS23150 ENOG4105D2B acyl-CoA dehydrogenase G6N66_RS23160 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) G6N66_RS23170 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G6N66_RS23175 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone G6N66_RS23195 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) G6N66_RS23215 ENOG4105F8J Adenylate Guanylate cyclase G6N66_RS23280 ENOG4105CMD Transcriptional regulator, GntR family G6N66_RS23300 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) G6N66_RS23320 ENOG4106NZI LysR family Transcriptional regulator G6N66_RS23350 ENOG41082SX arsR family transcriptional regulator G6N66_RS23380 ENOG4108UTW Plays a role in the regulation of phosphate uptake G6N66_RS23410 ENOG4107NHD transcriptional regulator G6N66_RS23420 ENOG4105K63 Thioredoxin G6N66_RS23435 ENOG4105PKJ carbohydrate binding G6N66_RS23440 ENOG4108X6U May play a role in the intracellular transport of hydrophobic ligands G6N66_RS23450 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) G6N66_RS23480 ENOG4107QY8 reductase G6N66_RS23520 ENOG4105DFM M18 family aminopeptidase G6N66_RS23525 ENOG4105EZR dyp-type peroxidase family protein G6N66_RS23535 ENOG4108RPX mosc domain containing protein G6N66_RS23585 ENOG4105CZE histidine utilization repressor G6N66_RS23600 ENOG410839H phosphoribosylformylglycinamidine synthase G6N66_RS23615 ENOG4105C0R drug resistance transporter emrb qaca subfamily G6N66_RS23625 ENOG4105C8V SAICAR synthetase G6N66_RS23650 ENOG4105C83 adenylosuccinate lyase G6N66_RS23710 ENOG4105EMU Dehydrogenase G6N66_RS23715 ENOG41068W2 Cytochrome p-450 G6N66_RS23755 ENOG4105BZU Histidine kinase G6N66_RS23760 ENOG4105CK6 Two component transcriptional regulator (Winged helix family G6N66_RS23805 ENOG4105GCF PGAM G6N66_RS23840 ENOG4105D2B acyl-CoA dehydrogenase G6N66_RS23860 ENOG4105DVW rieske (2Fe-2S) G6N66_RS23870 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) G6N66_RS23910 ENOG4107TB5 TRANSCRIPTIONal G6N66_RS23920 ENOG4105CHR reductase G6N66_RS24005 ENOG4105X7H acyl-CoA dehydrogenase G6N66_RS24010 ENOG4108KC2 acyl-Coa dehydrogenase G6N66_RS24015 ENOG4105J5T Amp-dependent synthetase and ligase G6N66_RS24045 ENOG4105E39 Enoyl-CoA hydratase G6N66_RS24065 ENOG4105DYW oxidoreductase G6N66_RS24105 ENOG4105CIJ rieske 2fe-2S domain-containing protein G6N66_RS24130 ENOG4105CHR reductase G6N66_RS24145 ENOG4105DF3 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity) G6N66_RS24150 ENOG4105DIV Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD( ) and coenzyme A. Is the final enzyme in the meta- cleavage pathway for the degradation of aromatic compounds (By similarity) G6N66_RS24155 ENOG4105IKQ hydratase G6N66_RS24160 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein G6N66_RS24180 ENOG410900P UPF0336 protein G6N66_RS24185 ENOG4105X7H acyl-CoA dehydrogenase G6N66_RS24190 ENOG4108RK3 acyl-Coa dehydrogenase G6N66_RS24200 ENOG4105F2C Acetyl-CoA acetyltransferase G6N66_RS24215 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr G6N66_RS24225 ENOG4105E39 Enoyl-CoA hydratase G6N66_RS24240 ENOG4105EA8 2-Nitropropane dioxygenase G6N66_RS24245 ENOG4105CHU acetyl-coa acetyltransferase G6N66_RS24260 ENOG4105CHR reductase G6N66_RS24265 ENOG4105CC9 acyl-Coa dehydrogenase G6N66_RS24270 ENOG4105CEY Amp-dependent synthetase and ligase G6N66_RS24275 ENOG4105CC9 acyl-Coa dehydrogenase G6N66_RS24280 ENOG4105D2B acyl-CoA dehydrogenase G6N66_RS24285 ENOG4105D2B acyl-CoA dehydrogenase G6N66_RS24365 ENOG4105D2B acyl-CoA dehydrogenase G6N66_RS24370 ENOG4108SGK Tetr family transcriptional regulator G6N66_RS24385 ENOG4105DIK (ABC) transporter G6N66_RS24390 ENOG4105CC5 ABC transporter G6N66_RS24445 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) G6N66_RS24490 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) G6N66_RS24495 ENOG4108JPZ Monovalent cation H antiporter subunit D G6N66_RS24505 ENOG4107TDF Formate hydrogenlyase subunit 4 G6N66_RS24515 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit G6N66_RS24595 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) G6N66_RS24630 ENOG4105EUJ GTP cyclohydrolase i G6N66_RS24635 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) G6N66_RS24645 ENOG4105D74 hydrolase G6N66_RS24655 ENOG4105CPQ Dehydrogenase G6N66_RS24660 ENOG4105KWG Pfam:DUF1696 G6N66_RS24670 ENOG4108UGV hypoxanthine phosphoribosyltransferase G6N66_RS24675 ENOG4107RD1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) G6N66_RS24730 ENOG4107QRG dna polymerase iii G6N66_RS24755 ENOG4108I5C dEAD DEAH box helicase G6N66_RS24815 ENOG4108JQ6 ABC transporter G6N66_RS24820 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component G6N66_RS24825 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component G6N66_RS24875 ENOG4107ZT5 Thiol disulfide interchange protein G6N66_RS24895 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) G6N66_RS24900 ENOG4105KME endoribonuclease L-psp G6N66_RS24925 ENOG4105BZ4 penicillin-binding protein G6N66_RS24970 ENOG4107XI7 Tetr family transcriptional regulator G6N66_RS24985 ENOG4107MMM Anti-sigma-factor antagonist G6N66_RS24990 ENOG4105FUA antagonist G6N66_RS24995 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase G6N66_RS25005 ENOG4108Q50 Histidine kinase G6N66_RS25020 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) G6N66_RS25025 ENOG4107R7Y intracellular protease Pfpi family G6N66_RS25030 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone G6N66_RS25050 ENOG4108WQ6 secreted protein G6N66_RS25055 ENOG4105C7R Atpase associated with various cellular activities aaa_3 G6N66_RS25080 ENOG4108EPX Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) G6N66_RS25085 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) G6N66_RS25090 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) G6N66_RS25100 ENOG4105CIH Imidazole acetol-phosphate transaminase G6N66_RS25105 ENOG4105C7K acetolactate synthase G6N66_RS25125 ENOG4105NTW Transcriptional regulator G6N66_RS25130 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) G6N66_RS25150 ENOG4105C92 Aminotransferase class V G6N66_RS25160 ENOG4108V75 Glutamine amidotransferase G6N66_RS25165 ENOG4105E46 N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process G6N66_RS25210 ENOG4108NJC G6N66_RS25225 ENOG41062IE glyoxalase bleomycin resistance protein dioxygenase G6N66_RS25250 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) G6N66_RS25275 ENOG4108RU2 n-acetylmuramoyl-l-alanine amidase G6N66_RS25290 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase G6N66_RS25295 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) G6N66_RS25305 ENOG4105CPQ Dehydrogenase G6N66_RS25315 ENOG4105XT2 Transcriptional regulator G6N66_RS25390 ENOG4108J08 Csbd family G6N66_RS25400 ENOG4105CMR udp-glucose 4-epimerase G6N66_RS25405 ENOG4105CHR reductase G6N66_RS25430 ENOG4105CHR reductase G6N66_RS25435 ENOG4105FBW Monooxygenase G6N66_RS25445 ENOG4105FUY alpha subunit G6N66_RS25465 ENOG41076PI Short-chain dehydrogenase reductase Sdr G6N66_RS25480 ENOG4105E1F short-chain dehydrogenase reductase G6N66_RS25515 ENOG4105RYD Toxic component of a toxin-antitoxin (TA) module. A G6N66_RS25570 ENOG4106A3M Cytochrome p-450 G6N66_RS25595 ENOG4108KR4 dihydrodipicolinate reductase G6N66_RS25620 ENOG4105CI0 Citrate lyase G6N66_RS25625 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G6N66_RS25640 ENOG4105F8J Adenylate Guanylate cyclase G6N66_RS25655 ENOG4108M8W Monooxygenase G6N66_RS25675 ENOG41082VC UPF0145 protein G6N66_RS25720 ENOG4105C79 DNA protecting protein DprA G6N66_RS25730 ENOG4108Z6B deaminase G6N66_RS25740 ENOG4105EVN Prephenate dehydrogenase G6N66_RS25755 ENOG4105E90 ABC transporter G6N66_RS25760 ENOG4108IJ8 ABC transporter G6N66_RS25770 ENOG41060H3 Protein of unknown function (DUF1049) G6N66_RS25795 ENOG4105CHR reductase G6N66_RS25820 ENOG4105EUZ Beta-lactamase domain protein G6N66_RS25830 ENOG4105BZU Histidine kinase G6N66_RS25835 ENOG4105CK6 Two component transcriptional regulator (Winged helix family G6N66_RS25875 ENOG4105C5I Dehydrogenase G6N66_RS25885 ENOG41086VY Fic/DOC family G6N66_RS25980 ENOG4105CBC glutamate synthase G6N66_RS26000 ENOG4105DCG PHP domain protein G6N66_RS26010 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) G6N66_RS26015 ENOG41060BG Tetr family transcriptional regulator G6N66_RS26075 ENOG4108KGH TRANSCRIPTIONal G6N66_RS26110 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) G6N66_RS26130 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) G6N66_RS26200 ENOG4105E9Q Acyl-transferase G6N66_RS26215 ENOG410667J hydrolase G6N66_RS26225 ENOG4106032 Glutathionylspermidine synthase G6N66_RS26230 ENOG4105P3N Membrane G6N66_RS26235 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) G6N66_RS26255 ENOG410602S Transferase G6N66_RS26270 ENOG4107ISF Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component the mycobacterial cell wall. Catalyzes the transfer of arabinofuranosyl (Araf) residues residue from the sugar donor beta-D-arabinofuranosyl-1-monophosphoryldecaprenol (DPA) to the arabinan domain to form terminal beta-(1- 2)-linked Araf residues, which marks the end point for AG arabinan biosynthesis before decoration with mycolic acids G6N66_RS26290 ENOG4107RCI amp-dependent synthetase and ligase G6N66_RS26300 ENOG4105D8K carboxyl transferase G6N66_RS26315 ENOG4105C1G acyl-Coa dehydrogenase G6N66_RS26330 ENOG4105J1Z Arabinosyltransferase G6N66_RS26335 ENOG4108NUW Cell wall arabinan synthesis protein G6N66_RS26365 ENOG4108K7T Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component the mycobacterial cell wall. Catalyzes the addition of the first key arabinofuranosyl (Araf) residue from the sugar donor beta-D-arabinofuranosyl-1-monophosphoryldecaprenol (DPA) on the C-5 of a 6-linked galactofuranosyl (Galf) of the galactan domain, thus 'priming' the galactan for further elaboration by other arabinofuranosyltransferases G6N66_RS26375 ENOG4105IQ5 FAD linked oxidase domain protein G6N66_RS26420 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein G6N66_RS26480 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone G6N66_RS26515 ENOG4105K4H Nlp p60 protein G6N66_RS26530 ENOG4105C1G acyl-Coa dehydrogenase G6N66_RS26550 ENOG4105TV9 FHA Domain-Containing protein G6N66_RS26575 ENOG4107TPY serine threonine protein kinase G6N66_RS26580 ENOG4105D9P serine threonine protein kinase G6N66_RS26605 ENOG4107XH4 PPIases accelerate the folding of proteins (By similarity) G6N66_RS26635 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) G6N66_RS26640 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) G6N66_RS26645 ENOG4105K7N UPF0232 protein G6N66_RS26650 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) G6N66_RS26655 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) G6N66_RS26660 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) G6N66_RS26675 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) G6N66_RS26680 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins G6N66_RS26690 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) G6N66_RS26695 ENOG4107QJE Chromosome Partitioning Protein G6N66_RS26710 ENOG4108E1C hydrolase G6N66_RS26825 ENOG4105DHU Bile acid G6N66_RS26835 ENOG41064CH Probable lipoprotein LpqN G6N66_RS26860 ENOG4105E5Q amino acid AbC transporter G6N66_RS26870 ENOG4105DYW oxidoreductase G6N66_RS26875 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) G6N66_RS26895 ENOG4105BZ4 penicillin-binding protein G6N66_RS26910 ENOG410829C Binds together with S18 to 16S ribosomal RNA (By similarity) G6N66_RS26960 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) G6N66_RS26980 ENOG4107SFI Major Facilitator superfamily G6N66_RS26985 ENOG4105CHU acetyl-coa acetyltransferase G6N66_RS27000 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) G6N66_RS27060 ENOG4105DYW oxidoreductase G6N66_RS27085 ENOG4105DDV Transcriptional regulator (LacI family G6N66_RS27095 ENOG4105CHR reductase G6N66_RS27100 ENOG4105F8J Adenylate Guanylate cyclase G6N66_RS27110 ENOG4105D7T ABC transporter G6N66_RS27120 ENOG4108IY8 ABC, transporter G6N66_RS27130 ENOG4105D7T ABC transporter G6N66_RS27140 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component G6N66_RS27150 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) G6N66_RS27160 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein G6N66_RS27170 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) G6N66_RS27180 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) G6N66_RS27185 ENOG4105EM7 Selenocysteine-specific translation elongation factor G6N66_RS27190 ENOG4105DYW oxidoreductase G6N66_RS27195 ENOG4108TAG Histidine kinase G6N66_RS27205 ENOG41063C6 UPF0235 protein G6N66_RS27210 ENOG4105E9K Isocitrate dehydrogenase G6N66_RS27215 ENOG4108R86 Transcriptional regulator G6N66_RS27220 ENOG4107FW0 short-chain dehydrogenase reductase G6N66_RS27225 ENOG4105HHS UPF0256 protein G6N66_RS27230 ENOG4105C1G acyl-Coa dehydrogenase G6N66_RS27240 ENOG4105KVH Transcriptional regulator G6N66_RS27260 ENOG4105CPC Aldo Keto reductase G6N66_RS27275 ENOG4105DVW rieske (2Fe-2S) G6N66_RS27315 ENOG4107VGR Catalase G6N66_RS27405 ENOG4108RZE Tetr family transcriptional regulator G6N66_RS27410 ENOG4108JGH Tetr family transcriptional regulator G6N66_RS27415 ENOG4105D2B acyl-CoA dehydrogenase G6N66_RS27445 ENOG4105CHR reductase G6N66_RS27455 ENOG4107XI7 Tetr family transcriptional regulator G6N66_RS27480 ENOG41082SK Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) G6N66_RS27485 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein G6N66_RS27510 ENOG4108SEA Esterase G6N66_RS27515 ENOG41076PI Short-chain dehydrogenase reductase Sdr G6N66_RS27535 ENOG4108IG5 Transcriptional regulator G6N66_RS27560 ENOG4107R5W Monooxygenase G6N66_RS27565 ENOG4105F95 Monooxygenase G6N66_RS27570 ENOG4105KV4 Transcriptional regulator G6N66_RS27585 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein G6N66_RS27595 ENOG4105CHR reductase G6N66_RS27615 ENOG4105CPQ Dehydrogenase G6N66_RS27645 ENOG4107S2E monooxygenase G6N66_RS27655 ENOG4105H37 Glyoxalase Bleomycin resistance protein (Dioxygenase G6N66_RS27680 ENOG4105CHR reductase G6N66_RS27685 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein G6N66_RS27705 ENOG4105CHR reductase G6N66_RS27715 ENOG4105EMU Dehydrogenase G6N66_RS27720 ENOG4107QNM Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) G6N66_RS27725 ENOG4105F2Z 3-oxoadipate enol-lactonase G6N66_RS27730 ENOG4108VHC Short-chain dehydrogenase reductase Sdr G6N66_RS27750 ENOG4105CEY Amp-dependent synthetase and ligase G6N66_RS27765 ENOG4105CHR reductase G6N66_RS27785 ENOG4105CFF transcriptional regulator G6N66_RS27795 ENOG4105CR4 methylisocitrate lyase G6N66_RS27800 ENOG4105BZN citrate synthase G6N66_RS27805 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) G6N66_RS27850 ENOG4105CEY Amp-dependent synthetase and ligase G6N66_RS27860 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family G6N66_RS27870 ENOG4105C7K acetolactate synthase G6N66_RS27880 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr G6N66_RS27885 ENOG4107R5W Monooxygenase G6N66_RS27895 ENOG4105H9W Short-chain dehydrogenase reductase Sdr G6N66_RS27910 ENOG4105CEY Amp-dependent synthetase and ligase G6N66_RS27940 ENOG4105C26 Dehydrogenase G6N66_RS27945 ENOG4105EXC Acyl-transferase G6N66_RS27975 ENOG4105FF0 ErfK YbiS YcfS YnhG G6N66_RS27985 ENOG4105CFN oxalyl-CoA decarboxylase G6N66_RS28040 ENOG4105CJ1 ABC, transporter G6N66_RS28085 ENOG4105EJ2 Transcriptional regulator G6N66_RS28105 ENOG4105DYW oxidoreductase G6N66_RS28150 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) G6N66_RS28185 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction G6N66_RS28190 ENOG4105PF9 Transcriptional regulator G6N66_RS28195 ENOG4108UGJ Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) G6N66_RS28210 ENOG4105C26 Dehydrogenase G6N66_RS28215 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr G6N66_RS28245 ENOG4105C1G acyl-Coa dehydrogenase G6N66_RS28255 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) G6N66_RS28260 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) G6N66_RS28265 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) G6N66_RS28275 ENOG4108R86 Transcriptional regulator G6N66_RS28295 ENOG4105CQB FAD linked oxidase domain protein G6N66_RS28330 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone G6N66_RS28335 ENOG4105X7H acyl-CoA dehydrogenase G6N66_RS28350 ENOG4105BZU Histidine kinase G6N66_RS28380 ENOG4105CNV Aldolase G6N66_RS28420 ENOG4105CY3 ABC transporter, permease G6N66_RS28480 ENOG4105XPP Protein of unknown function (DUF1275) G6N66_RS28550 ENOG4105E5G Alpha beta hydrolase fold G6N66_RS28590 ENOG4107QWG 2-Nitropropane dioxygenase G6N66_RS28595 ENOG4105C01 Dihydroxy-acid dehydratase G6N66_RS28600 ENOG4105VPX protein, conserved in bacteria G6N66_RS28610 ENOG4105S7A ErfK ybiS ycfS ynhG family protein G6N66_RS28615 ENOG4105S7A ErfK ybiS ycfS ynhG family protein G6N66_RS28625 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) G6N66_RS28635 ENOG4105C9K Endothelin-converting enzyme 1 G6N66_RS28685 ENOG4108I9W Membrane G6N66_RS28710 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) G6N66_RS28725 ENOG4105E39 Enoyl-CoA hydratase G6N66_RS28735 ENOG4105C1G acyl-Coa dehydrogenase