locus-tag	class	description
JN216_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
JN216_RS00010	COG4584	PFAM Integrase catalytic
JN216_RS00015	COG1484	DNA-dependent DNA replication
JN216_RS00020	COG0592	DNA-directed DNA polymerase activity
JN216_RS00030	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
JN216_RS00035	COG0187	DNA topoisomerase II activity
JN216_RS00040	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
JN216_RS00040	COG1372	Participates in initiation and elongation during chromosome replication
JN216_RS00075	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
JN216_RS00105	COG0515	serine threonine protein kinase
JN216_RS00130	COG1716	ATPase activity
JN216_RS00160	COG0318	PFAM AMP-dependent synthetase and ligase
JN216_RS00190	COG1960	acyl-CoA dehydrogenase activity
JN216_RS00270	COG0495	leucyl-tRNA aminoacylation
JN216_RS00285	COG1126	abc transporter atp-binding protein
JN216_RS00290	COG0765	amino acid transport
JN216_RS00300	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JN216_RS00315	COG1309	transcriptional regulator
JN216_RS00320	COG0596	Alpha beta hydrolase
JN216_RS00320	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
JN216_RS00365	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
JN216_RS00380	COG0360	Binds together with S18 to 16S ribosomal RNA
JN216_RS00440	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
JN216_RS00465	COG1028	Short-chain dehydrogenase reductase Sdr
JN216_RS00470	COG1804	L-carnitine dehydratase bile acid-inducible protein F
JN216_RS00485	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JN216_RS00505	COG1028	Short-chain dehydrogenase reductase Sdr
JN216_RS00515	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
JN216_RS00525	COG2124	cytochrome p450
JN216_RS00540	COG1902	pentaerythritol trinitrate reductase activity
JN216_RS00540	COG0446	pyridine nucleotide-disulphide oxidoreductase
JN216_RS00545	COG0446	pyridine nucleotide-disulphide oxidoreductase
JN216_RS00545	COG1902	pentaerythritol trinitrate reductase activity
JN216_RS00560	COG1960	acyl-CoA dehydrogenase activity
JN216_RS00565	COG1028	Short-chain dehydrogenase reductase Sdr
JN216_RS00635	COG0318	PFAM AMP-dependent synthetase and ligase
JN216_RS00645	COG1141	Ferredoxin
JN216_RS00660	COG1804	L-carnitine dehydratase bile acid-inducible protein F
JN216_RS00690	COG1012	belongs to the aldehyde dehydrogenase family
JN216_RS00700	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
JN216_RS00700	COG1042	CoA-binding domain protein
JN216_RS00700	COG0045	succinate-CoA ligase (ADP-forming) activity
JN216_RS00710	COG1053	succinate dehydrogenase
JN216_RS00725	COG0596	Alpha beta hydrolase
JN216_RS00740	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
JN216_RS00745	COG1804	L-carnitine dehydratase bile acid-inducible protein F
JN216_RS00755	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
JN216_RS00760	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
JN216_RS00835	COG1309	transcriptional regulator
JN216_RS00840	COG1309	transcriptional regulator
JN216_RS00855	COG1278	Cold shock
JN216_RS00865	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JN216_RS00875	COG1028	Short-chain dehydrogenase reductase Sdr
JN216_RS00890	COG1028	Short-chain dehydrogenase reductase Sdr
JN216_RS00920	COG1028	Short-chain dehydrogenase reductase Sdr
JN216_RS00925	COG0277	FAD linked oxidase domain protein
JN216_RS00935	COG2267	carboxylic ester hydrolase activity
JN216_RS00940	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
JN216_RS00950	COG1247	-acetyltransferase
JN216_RS00975	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
JN216_RS01020	COG1309	transcriptional regulator
JN216_RS01080	COG0659	secondary active sulfate transmembrane transporter activity
JN216_RS01090	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
JN216_RS01100	COG2124	cytochrome p450
JN216_RS01110	COG0714	Associated with various cellular activities
JN216_RS01130	COG0477	Major facilitator Superfamily
JN216_RS01150	COG0346	lactoylglutathione lyase activity
JN216_RS01190	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JN216_RS01210	COG4552	Acetyltransferase involved in intracellular survival and related
JN216_RS01215	COG1960	acyl-CoA dehydrogenase activity
JN216_RS01220	COG1309	transcriptional regulator
JN216_RS01235	COG5651	PPE family
JN216_RS01265	COG1404	Belongs to the peptidase S8 family
JN216_RS01285	COG0702	epimerase
JN216_RS01300	COG0069	glutamate synthase activity
JN216_RS01300	COG0070	glutamate synthase
JN216_RS01300	COG0067	glutamate synthase
JN216_RS01320	COG1796	DNA polymerase
JN216_RS01320	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
JN216_RS01335	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
JN216_RS01345	COG2072	flavoprotein involved in K transport
JN216_RS01385	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
JN216_RS01405	COG1316	TRANSCRIPTIONal
JN216_RS01495	COG0561	phosphatase activity
JN216_RS01515	COG1216	Glycosyl transferase, family 2
JN216_RS01530	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
JN216_RS01540	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
JN216_RS01545	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
JN216_RS01550	COG0318	PFAM AMP-dependent synthetase and ligase
JN216_RS01555	COG3321	synthase
JN216_RS01555	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
JN216_RS01555	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
JN216_RS01560	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
JN216_RS01575	COG1960	acyl-CoA dehydrogenase activity
JN216_RS01615	COG0640	Transcriptional regulator
JN216_RS01630	COG1028	Short-chain dehydrogenase reductase Sdr
JN216_RS01635	COG0277	FAD linked oxidase domain protein
JN216_RS01650	COG1403	HNH endonuclease
JN216_RS01685	COG0604	alcohol dehydrogenase
JN216_RS01705	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
JN216_RS01725	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
JN216_RS01770	COG0745	RESPONSE REGULATOR receiver
JN216_RS01775	COG2205	protein histidine kinase activity
JN216_RS01785	COG2015	COG2015, Alkyl sulfatase and related hydrolases
JN216_RS01830	COG5416	Lipopolysaccharide assembly protein A domain
JN216_RS01845	COG1174	glycine betaine transport
JN216_RS01860	COG0287	Prephenate dehydrogenase
JN216_RS01870	COG0590	tRNA wobble adenosine to inosine editing
JN216_RS01895	COG1511	domain protein
JN216_RS01940	COG1804	L-carnitine dehydratase bile acid-inducible protein F
JN216_RS01945	COG2301	Belongs to the HpcH HpaI aldolase family
JN216_RS01950	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
JN216_RS01960	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
JN216_RS01970	COG1396	sequence-specific DNA binding
JN216_RS01970	COG3800	Transcriptional regulator
JN216_RS01975	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JN216_RS01980	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
JN216_RS01990	COG1028	Short-chain dehydrogenase reductase Sdr
JN216_RS02000	COG3804	dihydrodipicolinate reductase
JN216_RS02020	COG0596	Alpha beta hydrolase
JN216_RS02025	COG2124	cytochrome p450
JN216_RS02045	COG1793	dna ligase
JN216_RS02060	COG1335	isochorismatase
JN216_RS02100	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
JN216_RS02125	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JN216_RS02135	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
JN216_RS02150	COG0860	N-Acetylmuramoyl-L-alanine amidase
JN216_RS02155	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
JN216_RS02175	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
JN216_RS02180	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
JN216_RS02225	COG1262	PFAM Formylglycine-generating sulfatase enzyme
JN216_RS02230	COG0121	glutamine amidotransferase
JN216_RS02240	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
JN216_RS02255	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
JN216_RS02260	COG1695	Transcriptional regulator
JN216_RS02285	COG0714	Associated with various cellular activities
JN216_RS02310	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JN216_RS02320	COG0693	protein deglycase activity
JN216_RS02325	COG2890	protein-(glutamine-N5) methyltransferase activity
JN216_RS02350	COG2172	sigma factor antagonist activity
JN216_RS02355	COG1366	Belongs to the anti-sigma-factor antagonist family
JN216_RS02360	COG1366	Belongs to the anti-sigma-factor antagonist family
JN216_RS02375	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JN216_RS02400	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
JN216_RS02405	COG1408	metallophosphoesterase
JN216_RS02440	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JN216_RS02455	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
JN216_RS02465	COG0494	nUDIX hydrolase
JN216_RS02490	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
JN216_RS02510	COG0601	transmembrane transport
JN216_RS02515	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JN216_RS02575	COG1111	helicase
JN216_RS02575	COG1205	dead DEAH box helicase
JN216_RS02600	COG0470	DNA polymerase III
JN216_RS02645	COG2027	D-alanyl-D-alanine carboxypeptidase
JN216_RS02655	COG0037	tRNA processing
JN216_RS02680	COG0657	acetylesterase activity
JN216_RS02690	COG1403	HNH endonuclease
JN216_RS02695	COG1063	alcohol dehydrogenase
JN216_RS02705	COG2267	carboxylic ester hydrolase activity
JN216_RS02720	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
JN216_RS02725	COG0302	gtp cyclohydrolase
JN216_RS02730	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
JN216_RS02735	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
JN216_RS02760	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
JN216_RS02840	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
JN216_RS02875	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
JN216_RS02885	COG1108	ABC-type Mn2 Zn2 transport systems permease components
JN216_RS02890	COG1121	(ABC) transporter
JN216_RS02900	COG1609	Transcriptional regulator
JN216_RS02905	COG1309	transcriptional regulator
JN216_RS02910	COG1960	acyl-CoA dehydrogenase activity
JN216_RS02960	COG0436	Aminotransferase
JN216_RS02965	COG1960	acyl-CoA dehydrogenase activity
JN216_RS02970	COG1960	acyl-CoA dehydrogenase activity
JN216_RS02975	COG1960	acyl-CoA dehydrogenase activity
JN216_RS02980	COG0318	PFAM AMP-dependent synthetase and ligase
JN216_RS02985	COG1960	acyl-CoA dehydrogenase activity
JN216_RS03000	COG0183	Belongs to the thiolase family
JN216_RS03030	COG1024	Enoyl-CoA hydratase
JN216_RS03035	COG1028	Short-chain dehydrogenase reductase Sdr
JN216_RS03040	COG1028	Short-chain dehydrogenase reductase Sdr
JN216_RS03060	COG0183	Belongs to the thiolase family
JN216_RS03065	COG2124	cytochrome p450
JN216_RS03070	COG1960	acyl-CoA dehydrogenase activity
JN216_RS03075	COG1960	acyl-CoA dehydrogenase activity
JN216_RS03080	COG2030	dehydratase
JN216_RS03100	COG2030	dehydratase
JN216_RS03105	COG1053	succinate dehydrogenase
JN216_RS03110	COG3971	2-oxopent-4-enoate hydratase activity
JN216_RS03115	COG4569	acetaldehyde dehydrogenase (acetylating) activity
JN216_RS03120	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
JN216_RS03135	COG1028	Short-chain dehydrogenase reductase Sdr
JN216_RS03150	COG4638	Rieske (2fe-2S)
JN216_RS03180	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JN216_RS03190	COG2124	cytochrome p450
JN216_RS03210	COG3001	Fructosamine kinase
JN216_RS03220	COG0028	Belongs to the TPP enzyme family
JN216_RS03235	COG0318	PFAM AMP-dependent synthetase and ligase
JN216_RS03240	COG1960	acyl-CoA dehydrogenase activity
JN216_RS03245	COG1960	acyl-CoA dehydrogenase activity
JN216_RS03255	COG1028	Short-chain dehydrogenase reductase Sdr
JN216_RS03260	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
JN216_RS03265	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
JN216_RS03290	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
JN216_RS03325	COG1024	Enoyl-CoA hydratase
JN216_RS03340	COG1316	TRANSCRIPTIONal
JN216_RS03410	COG0745	RESPONSE REGULATOR receiver
JN216_RS03415	COG2205	protein histidine kinase activity
JN216_RS03445	COG2124	cytochrome p450
JN216_RS03450	COG4221	oxidoreductase activity
JN216_RS03485	COG0667	Aldo Keto reductase
JN216_RS03520	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
JN216_RS03540	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
JN216_RS03550	COG0477	Major facilitator Superfamily
JN216_RS03555	COG0477	Major facilitator Superfamily
JN216_RS03570	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
JN216_RS03580	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
JN216_RS03585	COG0047	phosphoribosylformylglycinamidine synthase activity
JN216_RS03595	COG0204	Acyl-transferase
JN216_RS03600	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
JN216_RS03615	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
JN216_RS03655	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
JN216_RS03655	COG1017	nitric oxide dioxygenase activity
JN216_RS03665	COG2837	iron assimilation
JN216_RS03715	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
JN216_RS03765	COG0745	RESPONSE REGULATOR receiver
JN216_RS03790	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
JN216_RS03830	COG0640	Transcriptional regulator
JN216_RS03835	COG0590	tRNA wobble adenosine to inosine editing
JN216_RS03865	COG4974	Belongs to the 'phage' integrase family
JN216_RS03885	COG1609	Transcriptional regulator
JN216_RS03895	COG1309	transcriptional regulator
JN216_RS03920	COG1484	DNA-dependent DNA replication
JN216_RS03925	COG4584	PFAM Integrase catalytic
JN216_RS03935	COG1033	growth of symbiont in host cell
JN216_RS03935	COG2409	Drug exporters of the RND superfamily
JN216_RS03985	COG3344	reverse transcriptase
JN216_RS03995	COG3328	transposase activity
JN216_RS04000	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
JN216_RS04045	COG3344	reverse transcriptase
JN216_RS04050	COG1309	transcriptional regulator
JN216_RS04065	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JN216_RS04095	COG2072	flavoprotein involved in K transport
JN216_RS04100	COG2072	flavoprotein involved in K transport
JN216_RS04120	COG0318	PFAM AMP-dependent synthetase and ligase
JN216_RS04125	COG1960	acyl-CoA dehydrogenase activity
JN216_RS04150	COG1090	epimerase
JN216_RS04160	COG2030	dehydratase
JN216_RS04170	COG1848	Toxic component of a toxin-antitoxin (TA) module. An RNase
JN216_RS04225	COG1309	transcriptional regulator
JN216_RS04235	COG0183	Belongs to the thiolase family
JN216_RS04240	COG0318	PFAM AMP-dependent synthetase and ligase
JN216_RS04245	COG1024	Enoyl-CoA hydratase
JN216_RS04250	COG1960	acyl-CoA dehydrogenase activity
JN216_RS04265	COG2826	transposase and inactivated derivatives, IS30 family
JN216_RS04300	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
JN216_RS04305	COG3328	transposase activity
JN216_RS04340	COG1028	Short-chain dehydrogenase reductase Sdr
JN216_RS04355	COG2124	cytochrome p450
JN216_RS04360	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JN216_RS04365	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
JN216_RS04385	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
JN216_RS04385	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
JN216_RS04390	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
JN216_RS04395	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JN216_RS04400	COG1804	L-carnitine dehydratase bile acid-inducible protein F
JN216_RS04435	COG1960	acyl-CoA dehydrogenase activity
JN216_RS04440	COG1960	acyl-CoA dehydrogenase activity
JN216_RS04450	COG2267	carboxylic ester hydrolase activity
JN216_RS04455	COG3479	Phenolic acid decarboxylase
JN216_RS04460	COG0183	Belongs to the thiolase family
JN216_RS04465	COG1703	isobutyryl-CoA mutase activity
JN216_RS04470	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
JN216_RS04480	COG4585	Histidine kinase
JN216_RS04490	COG0504	CTP synthase activity
JN216_RS04495	COG1053	succinate dehydrogenase
JN216_RS04505	COG2267	carboxylic ester hydrolase activity
JN216_RS04510	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
JN216_RS04515	COG3384	dioxygenase
JN216_RS04520	COG1053	succinate dehydrogenase
JN216_RS04530	COG1028	Short-chain dehydrogenase reductase Sdr
JN216_RS04545	COG2132	Multicopper oxidase
JN216_RS04560	COG2197	response regulator
JN216_RS04565	COG1028	Short-chain dehydrogenase reductase Sdr
JN216_RS04620	COG1024	Enoyl-CoA hydratase
JN216_RS04625	COG1804	L-carnitine dehydratase bile acid-inducible protein F
JN216_RS04630	COG1028	Short-chain dehydrogenase reductase Sdr
JN216_RS04640	COG1028	Short-chain dehydrogenase reductase Sdr
JN216_RS04650	COG1960	acyl-CoA dehydrogenase activity
JN216_RS04665	COG1960	acyl-CoA dehydrogenase activity
JN216_RS04675	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
JN216_RS04685	COG4638	Rieske (2fe-2S)
JN216_RS04705	COG1024	Enoyl-CoA hydratase
JN216_RS04710	COG0183	Belongs to the thiolase family
JN216_RS04715	COG1309	transcriptional regulator
JN216_RS04745	COG2124	cytochrome p450
JN216_RS04750	COG2084	Dehydrogenase
JN216_RS04790	COG1960	acyl-CoA dehydrogenase activity
JN216_RS04800	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
JN216_RS04840	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
JN216_RS04840	COG0778	Nitroreductase
JN216_RS04845	COG1960	acyl-CoA dehydrogenase activity
JN216_RS04850	COG1960	acyl-CoA dehydrogenase activity
JN216_RS04890	COG1804	L-carnitine dehydratase bile acid-inducible protein F
JN216_RS04895	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
JN216_RS04900	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
JN216_RS04925	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
JN216_RS04995	COG1024	Enoyl-CoA hydratase
JN216_RS05010	COG0318	PFAM AMP-dependent synthetase and ligase
JN216_RS05035	COG1804	L-carnitine dehydratase bile acid-inducible protein F
JN216_RS05055	COG0183	Belongs to the thiolase family
JN216_RS05060	COG1024	Enoyl-CoA hydratase
JN216_RS05060	COG1250	3-hydroxyacyl-CoA dehydrogenase
JN216_RS05065	COG2813	Specifically methylates the guanine in position
JN216_RS05085	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JN216_RS05110	COG0183	Belongs to the thiolase family
JN216_RS05115	COG1061	Type III restriction enzyme res subunit
JN216_RS05155	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
JN216_RS05160	COG3304	Inner membrane component domain
JN216_RS05165	COG1278	Cold shock
JN216_RS05175	COG0435	Glutathione S-transferase
JN216_RS05190	COG2814	Major facilitator Superfamily
JN216_RS05230	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
JN216_RS05255	COG0259	pyridoxamine-phosphate oxidase activity
JN216_RS05375	COG1484	DNA-dependent DNA replication
JN216_RS05380	COG4584	PFAM Integrase catalytic
JN216_RS05390	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JN216_RS05430	COG0581	inorganic phosphate transmembrane transporter activity
JN216_RS05455	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
JN216_RS05490	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
JN216_RS05520	COG4942	peptidase
JN216_RS05560	COG0138	bifunctional purine biosynthesis protein purh
JN216_RS05580	COG0656	L-ascorbic acid biosynthetic process
JN216_RS05590	COG1024	Enoyl-CoA hydratase
JN216_RS05605	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
JN216_RS05610	COG1960	acyl-CoA dehydrogenase activity
JN216_RS05640	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
JN216_RS05645	COG0315	cyclic pyranopterin monophosphate synthase activity
JN216_RS05645	COG0521	Mo-molybdopterin cofactor biosynthetic process
JN216_RS05650	COG1970	mechanosensitive ion channel activity
JN216_RS05665	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
JN216_RS05670	COG1210	Utp--glucose-1-phosphate uridylyltransferase
JN216_RS05705	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JN216_RS05745	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
JN216_RS05750	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
JN216_RS05755	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
JN216_RS05755	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
JN216_RS05800	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
JN216_RS05810	COG1252	NADH dehydrogenase
JN216_RS05885	COG0297	glycogen (starch) synthase activity
JN216_RS05900	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
JN216_RS05950	COG0084	hydrolase, TatD family'
JN216_RS05965	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
JN216_RS05970	COG0318	PFAM AMP-dependent synthetase and ligase
JN216_RS05975	COG0193	aminoacyl-tRNA hydrolase activity
JN216_RS05980	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
JN216_RS06025	COG1309	transcriptional regulator
JN216_RS06040	COG3956	TIGRFAM MazG family protein
JN216_RS06085	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
JN216_RS06090	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
JN216_RS06105	COG2205	protein histidine kinase activity
JN216_RS06110	COG0745	RESPONSE REGULATOR receiver
JN216_RS06195	COG3391	amine dehydrogenase activity
JN216_RS06200	COG0318	PFAM AMP-dependent synthetase and ligase
JN216_RS06210	COG0121	glutamine amidotransferase
JN216_RS06255	COG1024	Enoyl-CoA hydratase
JN216_RS06265	COG2826	transposase and inactivated derivatives, IS30 family
JN216_RS06270	COG0183	Belongs to the thiolase family
JN216_RS06275	COG2755	lipolytic protein G-D-S-L family
JN216_RS06280	COG0657	acetylesterase activity
JN216_RS06320	COG1331	Highly conserved protein containing a thioredoxin domain
JN216_RS06335	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
JN216_RS06345	COG0572	uridine kinase
JN216_RS06360	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
JN216_RS06410	COG2272	Belongs to the type-B carboxylesterase lipase family
JN216_RS06425	COG1570	exodeoxyribonuclease VII activity
JN216_RS06435	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
JN216_RS06445	COG0012	GTP binding
JN216_RS06515	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
JN216_RS06545	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
JN216_RS06545	COG0574	Belongs to the PEP-utilizing enzyme family
JN216_RS06575	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
JN216_RS06580	COG0702	epimerase
JN216_RS06590	COG1309	transcriptional regulator
JN216_RS06600	COG1960	acyl-CoA dehydrogenase activity
JN216_RS06605	COG1960	acyl-CoA dehydrogenase activity
JN216_RS06610	COG1028	Short-chain dehydrogenase reductase Sdr
JN216_RS06620	COG0714	Associated with various cellular activities
JN216_RS06635	COG1028	Short-chain dehydrogenase reductase Sdr
JN216_RS06640	COG2124	cytochrome p450
JN216_RS06645	COG1012	belongs to the aldehyde dehydrogenase family
JN216_RS06650	COG0183	Belongs to the thiolase family
JN216_RS06655	COG1024	Enoyl-CoA hydratase
JN216_RS06665	COG1755	Isoprenylcysteine carboxyl methyltransferase
JN216_RS06675	COG0702	epimerase
JN216_RS06685	COG0702	epimerase
JN216_RS06690	COG1024	Enoyl-CoA hydratase
JN216_RS06695	COG1804	L-carnitine dehydratase bile acid-inducible protein F
JN216_RS06705	COG2409	Drug exporters of the RND superfamily
JN216_RS06715	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
JN216_RS06730	COG3467	pyridoxamine 5'-phosphate
JN216_RS06790	COG1140	nitrate reductase beta subunit
JN216_RS06805	COG1217	gtp-binding protein TYPA
JN216_RS06820	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
JN216_RS06830	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
JN216_RS06845	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
JN216_RS06855	COG0531	amino acid
JN216_RS06860	COG3321	synthase
JN216_RS06860	COG1028	Short-chain dehydrogenase reductase Sdr
JN216_RS06860	COG0604	alcohol dehydrogenase
JN216_RS06875	COG0529	Catalyzes the synthesis of activated sulfate
JN216_RS06880	COG2046	Belongs to the sulfate adenylyltransferase family
JN216_RS06895	COG0318	PFAM AMP-dependent synthetase and ligase
JN216_RS06910	COG1012	belongs to the aldehyde dehydrogenase family
JN216_RS06920	COG2826	transposase and inactivated derivatives, IS30 family
JN216_RS06925	COG1309	transcriptional regulator
JN216_RS06950	COG1012	belongs to the aldehyde dehydrogenase family
JN216_RS06960	COG0318	PFAM AMP-dependent synthetase and ligase
JN216_RS06965	COG0477	Major facilitator Superfamily
JN216_RS07000	COG1611	Belongs to the LOG family
JN216_RS07005	COG0318	PFAM AMP-dependent synthetase and ligase
JN216_RS07015	COG0463	Glycosyl transferase, family 2
JN216_RS07025	COG0519	Catalyzes the synthesis of GMP from XMP
JN216_RS07040	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
JN216_RS07050	COG3559	Exporter of polyketide antibiotics
JN216_RS07055	COG1131	(ABC) transporter
JN216_RS07060	COG1309	transcriptional regulator
JN216_RS07075	COG5662	AntiSigma factor
JN216_RS07080	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
JN216_RS07085	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
JN216_RS07110	COG2239	Acts as a magnesium transporter
JN216_RS07150	COG0598	Magnesium transport protein CorA
JN216_RS07155	COG0039	L-malate dehydrogenase activity
JN216_RS07180	COG0508	dehydrogenase complex catalyzes the overall conversion of
JN216_RS07180	COG0567	Dehydrogenase, E1 component
JN216_RS07265	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
JN216_RS07290	COG1804	L-carnitine dehydratase bile acid-inducible protein F
JN216_RS07295	COG1028	Short-chain dehydrogenase reductase Sdr
JN216_RS07300	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
JN216_RS07305	COG1960	acyl-CoA dehydrogenase activity
JN216_RS07310	COG1960	acyl-CoA dehydrogenase activity
JN216_RS07315	COG1024	Enoyl-CoA hydratase
JN216_RS07320	COG1028	Short-chain dehydrogenase reductase Sdr
JN216_RS07325	COG0318	PFAM AMP-dependent synthetase and ligase
JN216_RS07350	COG0318	PFAM AMP-dependent synthetase and ligase
JN216_RS07355	COG2124	cytochrome p450
JN216_RS07370	COG1960	acyl-CoA dehydrogenase activity
JN216_RS07390	COG1960	acyl-CoA dehydrogenase activity
JN216_RS07400	COG0657	acetylesterase activity
JN216_RS07405	COG1028	Short-chain dehydrogenase reductase Sdr
JN216_RS07420	COG0183	Belongs to the thiolase family
JN216_RS07435	COG2124	cytochrome p450
JN216_RS07470	COG1309	transcriptional regulator
JN216_RS07475	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
JN216_RS07480	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
JN216_RS07505	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
JN216_RS07540	COG1804	L-carnitine dehydratase bile acid-inducible protein F
JN216_RS07545	COG2186	Transcriptional regulator
JN216_RS07550	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JN216_RS07580	COG1028	Short-chain dehydrogenase reductase Sdr
JN216_RS07595	COG1028	Short-chain dehydrogenase reductase Sdr
JN216_RS07600	COG1960	acyl-CoA dehydrogenase activity
JN216_RS07605	COG1960	acyl-CoA dehydrogenase activity
JN216_RS07610	COG4221	oxidoreductase activity
JN216_RS07620	COG0183	Belongs to the thiolase family
JN216_RS07625	COG1024	Enoyl-CoA hydratase
JN216_RS07640	COG1960	acyl-CoA dehydrogenase activity
JN216_RS07650	COG1960	acyl-CoA dehydrogenase activity
JN216_RS07655	COG1012	belongs to the aldehyde dehydrogenase family
JN216_RS07670	COG1028	Short-chain dehydrogenase reductase Sdr
JN216_RS07675	COG1028	Short-chain dehydrogenase reductase Sdr
JN216_RS07680	COG0427	acetyl-CoA hydrolase
JN216_RS07685	COG1960	acyl-CoA dehydrogenase activity
JN216_RS07700	COG0183	Belongs to the thiolase family
JN216_RS07705	COG0318	PFAM AMP-dependent synthetase and ligase
JN216_RS07805	COG1960	acyl-CoA dehydrogenase activity
JN216_RS07810	COG1960	acyl-CoA dehydrogenase activity
JN216_RS07815	COG1960	acyl-CoA dehydrogenase activity
JN216_RS07825	COG1024	Enoyl-CoA hydratase
JN216_RS07840	COG1960	acyl-CoA dehydrogenase activity
JN216_RS07845	COG1024	Enoyl-CoA hydratase
JN216_RS07850	COG2267	carboxylic ester hydrolase activity
JN216_RS07865	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JN216_RS07880	COG1012	belongs to the aldehyde dehydrogenase family
JN216_RS07885	COG1024	Enoyl-CoA hydratase
JN216_RS07925	COG3971	2-oxopent-4-enoate hydratase activity
JN216_RS07935	COG1960	acyl-CoA dehydrogenase activity
JN216_RS07940	COG1960	acyl-CoA dehydrogenase activity
JN216_RS07945	COG0183	Belongs to the thiolase family
JN216_RS07950	COG0318	PFAM AMP-dependent synthetase and ligase
JN216_RS07965	COG1804	L-carnitine dehydratase bile acid-inducible protein F
JN216_RS08015	COG1028	Short-chain dehydrogenase reductase Sdr
JN216_RS08020	COG0318	PFAM AMP-dependent synthetase and ligase
JN216_RS08040	COG1024	Enoyl-CoA hydratase
JN216_RS08050	COG0673	inositol 2-dehydrogenase activity
JN216_RS08090	COG1804	L-carnitine dehydratase bile acid-inducible protein F
JN216_RS08095	COG1804	L-carnitine dehydratase bile acid-inducible protein F
JN216_RS08100	COG3384	dioxygenase
JN216_RS08130	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JN216_RS08140	COG0778	Nitroreductase
JN216_RS08145	COG1960	acyl-CoA dehydrogenase activity
JN216_RS08175	COG1960	acyl-CoA dehydrogenase activity
JN216_RS08185	COG0318	PFAM AMP-dependent synthetase and ligase
JN216_RS08200	COG1484	DNA-dependent DNA replication
JN216_RS08205	COG4584	PFAM Integrase catalytic
JN216_RS08235	COG4569	acetaldehyde dehydrogenase (acetylating) activity
JN216_RS08245	COG1522	sequence-specific DNA binding
JN216_RS08250	COG4638	Rieske (2fe-2S)
JN216_RS08295	COG1846	Transcriptional regulator
JN216_RS08310	COG3971	2-oxopent-4-enoate hydratase activity
JN216_RS08320	COG1942	4-Oxalocrotonate Tautomerase
JN216_RS08340	COG1309	transcriptional regulator
JN216_RS08375	COG4638	Rieske (2fe-2S)
JN216_RS08380	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
JN216_RS08390	COG0179	Fumarylacetoacetate (FAA) hydrolase
JN216_RS08395	COG1309	transcriptional regulator
JN216_RS08410	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
JN216_RS08435	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
JN216_RS08455	COG0277	FAD linked oxidase domain protein
JN216_RS08470	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JN216_RS08620	COG3631	Ketosteroid isomerase-related protein
JN216_RS08625	COG0494	nUDIX hydrolase
JN216_RS08650	COG0018	arginyl-trna synthetase
JN216_RS08655	COG0019	diaminopimelate decarboxylase activity
JN216_RS08660	COG0460	homoserine dehydrogenase
JN216_RS08670	COG0083	homoserine kinase activity
JN216_RS08690	COG2890	protein-(glutamine-N5) methyltransferase activity
JN216_RS08710	COG0356	it plays a direct role in the translocation of protons across the membrane
JN216_RS08715	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
JN216_RS08725	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
JN216_RS08725	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
JN216_RS08760	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
JN216_RS08780	COG5651	PPE family
JN216_RS08805	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
JN216_RS08825	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
JN216_RS08850	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
JN216_RS08860	COG0058	SHG alpha-glucan phosphorylase activity
JN216_RS08870	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
JN216_RS08900	COG1234	tRNA 3'-trailer cleavage
JN216_RS08905	COG2123	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
JN216_RS08910	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
JN216_RS08935	COG3011	Protein conserved in bacteria
JN216_RS08965	COG1028	Short-chain dehydrogenase reductase Sdr
JN216_RS08970	COG1960	acyl-CoA dehydrogenase activity
JN216_RS08980	COG0183	Belongs to the thiolase family
JN216_RS08985	COG1804	L-carnitine dehydratase bile acid-inducible protein F
JN216_RS08990	COG1960	acyl-CoA dehydrogenase activity
JN216_RS08995	COG1802	Transcriptional regulator
JN216_RS09000	COG4977	sequence-specific DNA binding
JN216_RS09030	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
JN216_RS09035	COG1024	Enoyl-CoA hydratase
JN216_RS09040	COG1024	Enoyl-CoA hydratase
JN216_RS09045	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
JN216_RS09065	COG1028	Short-chain dehydrogenase reductase Sdr
JN216_RS09070	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
JN216_RS09080	COG1024	Enoyl-CoA hydratase
JN216_RS09105	COG1960	acyl-CoA dehydrogenase activity
JN216_RS09115	COG0183	Belongs to the thiolase family
JN216_RS09165	COG4638	Rieske (2fe-2S)
JN216_RS09175	COG2072	flavoprotein involved in K transport
JN216_RS09195	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
JN216_RS09210	COG1309	transcriptional regulator
JN216_RS09230	COG2124	cytochrome p450
JN216_RS09235	COG0657	acetylesterase activity
JN216_RS09240	COG1960	acyl-CoA dehydrogenase activity
JN216_RS09245	COG1960	acyl-CoA dehydrogenase activity
JN216_RS09270	COG1960	acyl-CoA dehydrogenase activity
JN216_RS09275	COG1960	acyl-CoA dehydrogenase activity
JN216_RS09280	COG1960	acyl-CoA dehydrogenase activity
JN216_RS09285	COG1960	acyl-CoA dehydrogenase activity
JN216_RS09315	COG2124	cytochrome p450
JN216_RS09375	COG3757	hydrolase, family 25
JN216_RS09380	COG3321	synthase
JN216_RS09380	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
JN216_RS09380	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
JN216_RS09385	COG0736	holo-[acyl-carrier-protein] synthase activity
JN216_RS09435	COG4552	Acetyltransferase involved in intracellular survival and related
JN216_RS09440	COG2409	Drug exporters of the RND superfamily
JN216_RS09445	COG0697	spore germination
JN216_RS09450	COG1376	ErfK ybiS ycfS ynhG family protein
JN216_RS09470	COG0433	COG0433 Predicted ATPase
JN216_RS09475	COG0300	oxidoreductase activity
JN216_RS09495	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
JN216_RS09505	COG1960	acyl-CoA dehydrogenase activity
JN216_RS09510	COG2030	dehydratase
JN216_RS09530	COG0508	dehydrogenase complex catalyzes the overall conversion of
JN216_RS09550	COG0657	acetylesterase activity
JN216_RS09565	COG2937	Belongs to the GPAT DAPAT family
JN216_RS09580	COG0629	single-stranded DNA binding
JN216_RS09590	COG2902	Dehydrogenase
JN216_RS09610	COG0366	Alpha amylase catalytic
JN216_RS09615	COG2346	COG2346, Truncated hemoglobins
JN216_RS09640	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
JN216_RS09645	COG0698	ribose 5-phosphate isomerase
JN216_RS09660	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
JN216_RS09680	COG0740	serine-type endopeptidase activity
JN216_RS09685	COG0740	serine-type endopeptidase activity
JN216_RS09690	COG2826	transposase and inactivated derivatives, IS30 family
JN216_RS09695	COG2040	homocysteine
JN216_RS09710	COG0674	pyruvate-flavodoxin oxidoreductase activity
JN216_RS09710	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
JN216_RS09715	COG1013	pyruvate-flavodoxin oxidoreductase activity
JN216_RS09725	COG1388	LysM domain
JN216_RS09730	COG3268	Saccharopine dehydrogenase
JN216_RS09735	COG0525	valine-tRNA ligase activity
JN216_RS09740	COG0285	dihydrofolate synthase activity
JN216_RS09750	COG0105	UTP biosynthetic process
JN216_RS09755	COG1530	ribonuclease E activity
JN216_RS09770	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
JN216_RS09800	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
JN216_RS09800	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
JN216_RS09805	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JN216_RS09810	COG5002	protein histidine kinase activity
JN216_RS09815	COG0668	transmembrane transport
JN216_RS09820	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
JN216_RS09825	COG0542	response to heat
JN216_RS09835	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
JN216_RS09840	COG0799	negative regulation of ribosome biogenesis
JN216_RS09850	COG2755	lipolytic protein G-D-S-L family
JN216_RS09875	COG0318	PFAM AMP-dependent synthetase and ligase
JN216_RS09880	COG5651	PPE family
JN216_RS09885	COG2409	Drug exporters of the RND superfamily
JN216_RS09905	COG1960	acyl-CoA dehydrogenase activity
JN216_RS09910	COG1960	acyl-CoA dehydrogenase activity
JN216_RS09915	COG1555	photosystem II stabilization
JN216_RS09915	COG1596	polysaccharide export
JN216_RS09920	COG0658	competence protein
JN216_RS09920	COG2333	competence protein COMEC
JN216_RS09945	COG1305	Transglutaminase-like
JN216_RS09950	COG1733	regulation of RNA biosynthetic process
JN216_RS09965	COG1234	tRNA 3'-trailer cleavage
JN216_RS09970	COG0517	IMP dehydrogenase activity
JN216_RS09980	COG0481	GTPase activity
JN216_RS09995	COG3387	PFAM Glycoside hydrolase 15-related
JN216_RS10005	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
JN216_RS10010	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
JN216_RS10015	COG4208	sulfate ABC transporter
JN216_RS10020	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
JN216_RS10030	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
JN216_RS10050	COG1169	isochorismate synthase
JN216_RS10060	COG2072	flavoprotein involved in K transport
JN216_RS10080	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
JN216_RS10085	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
JN216_RS10105	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
JN216_RS10115	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
JN216_RS10155	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
JN216_RS10170	COG2124	cytochrome p450
JN216_RS10190	COG1028	Short-chain dehydrogenase reductase Sdr
JN216_RS10215	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
JN216_RS10230	COG0318	PFAM AMP-dependent synthetase and ligase
JN216_RS10250	COG1063	alcohol dehydrogenase
JN216_RS10305	COG1960	acyl-CoA dehydrogenase activity
JN216_RS10320	COG1960	acyl-CoA dehydrogenase activity
JN216_RS10335	COG1804	L-carnitine dehydratase bile acid-inducible protein F
JN216_RS10365	COG1960	acyl-CoA dehydrogenase activity
JN216_RS10375	COG1960	acyl-CoA dehydrogenase activity
JN216_RS10380	COG1960	acyl-CoA dehydrogenase activity
JN216_RS10385	COG1021	2,3-dihydroxybenzoate-AMP ligase
JN216_RS10420	COG1024	Enoyl-CoA hydratase
JN216_RS10430	COG1960	acyl-CoA dehydrogenase activity
JN216_RS10435	COG1024	Enoyl-CoA hydratase
JN216_RS10445	COG1024	Enoyl-CoA hydratase
JN216_RS10450	COG1028	Short-chain dehydrogenase reductase Sdr
JN216_RS10455	COG0318	PFAM AMP-dependent synthetase and ligase
JN216_RS10485	COG1024	Enoyl-CoA hydratase
JN216_RS10500	COG1960	acyl-CoA dehydrogenase activity
JN216_RS10515	COG1024	Enoyl-CoA hydratase
JN216_RS10585	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
JN216_RS10660	COG0281	malic enzyme
JN216_RS10665	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
JN216_RS10680	COG1309	transcriptional regulator
JN216_RS10700	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
JN216_RS10705	COG1021	2,3-dihydroxybenzoate-AMP ligase
JN216_RS10710	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
JN216_RS10725	COG3321	synthase
JN216_RS10725	COG0604	alcohol dehydrogenase
JN216_RS10730	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
JN216_RS10740	COG3486	L-lysine 6-monooxygenase (NADPH) activity
JN216_RS10760	COG1595	DNA-templated transcription, initiation
JN216_RS10775	COG1420	regulation of RNA biosynthetic process
JN216_RS10780	COG0484	heat shock protein binding
JN216_RS10815	COG1982	Orn Lys Arg decarboxylase major
JN216_RS10825	COG1381	Involved in DNA repair and RecF pathway recombination
JN216_RS10850	COG0423	glycine-tRNA ligase activity
JN216_RS10895	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JN216_RS10900	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JN216_RS10910	COG1045	serine acetyltransferase
JN216_RS10925	COG2855	membrane
JN216_RS10935	COG4424	Sulfotransferase
JN216_RS10945	COG0243	molybdopterin cofactor binding
JN216_RS10960	COG1131	(ABC) transporter
JN216_RS10960	COG0842	Transport permease protein
JN216_RS10960	COG1716	ATPase activity
JN216_RS10985	COG0531	amino acid
JN216_RS11000	COG1175	transmembrane transport
JN216_RS11035	COG2267	carboxylic ester hydrolase activity
JN216_RS11065	COG1012	belongs to the aldehyde dehydrogenase family
JN216_RS11090	COG1366	Belongs to the anti-sigma-factor antagonist family
JN216_RS11090	COG2172	sigma factor antagonist activity
JN216_RS11090	COG2208	phosphoserine phosphatase activity
JN216_RS11110	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
JN216_RS11115	COG2226	methyltransferase
JN216_RS11195	COG2132	Multicopper oxidase
JN216_RS11220	COG0596	Alpha beta hydrolase
JN216_RS11235	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
JN216_RS11250	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JN216_RS11290	COG0798	PFAM Bile acid sodium symporter
JN216_RS11315	COG2124	cytochrome p450
JN216_RS11325	COG0438	transferase activity, transferring glycosyl groups
JN216_RS11340	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
JN216_RS11355	COG0657	acetylesterase activity
JN216_RS11360	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
JN216_RS11375	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
JN216_RS11395	COG1309	transcriptional regulator
JN216_RS11450	COG1487	ribonuclease activity
JN216_RS11485	COG1960	acyl-CoA dehydrogenase activity
JN216_RS11490	COG0860	N-Acetylmuramoyl-L-alanine amidase
JN216_RS11505	COG2072	flavoprotein involved in K transport
JN216_RS11630	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
JN216_RS11675	COG0596	Alpha beta hydrolase
JN216_RS11680	COG0346	lactoylglutathione lyase activity
JN216_RS11685	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
JN216_RS11845	COG0321	lipoyl(octanoyl) transferase activity
JN216_RS11880	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
JN216_RS11890	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
JN216_RS11895	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
JN216_RS11900	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
JN216_RS11930	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JN216_RS11935	COG2826	transposase and inactivated derivatives, IS30 family
JN216_RS11945	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
JN216_RS11980	COG1845	cytochrome c oxidase, subunit III
JN216_RS12010	COG1022	Amp-dependent synthetase and ligase
JN216_RS12025	COG0003	Pfam Anion-transporting ATPase
JN216_RS12055	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
JN216_RS12075	COG0142	geranyltranstransferase activity
JN216_RS12115	COG0768	penicillin binding
JN216_RS12140	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
JN216_RS12155	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
JN216_RS12170	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
JN216_RS12215	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JN216_RS12225	COG0167	dihydroorotate dehydrogenase activity
JN216_RS12260	COG1218	3'(2'),5'-bisphosphate nucleotidase
JN216_RS12265	COG0215	cysteine-tRNA ligase activity
JN216_RS12295	COG1028	Short-chain dehydrogenase reductase Sdr
JN216_RS12295	COG3321	synthase
JN216_RS12295	COG0604	alcohol dehydrogenase
JN216_RS12300	COG2124	cytochrome p450
JN216_RS12320	COG1028	Short-chain dehydrogenase reductase Sdr
JN216_RS12380	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
JN216_RS12390	COG1309	transcriptional regulator
JN216_RS12455	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
JN216_RS12475	COG2378	regulation of single-species biofilm formation
JN216_RS12530	COG0300	oxidoreductase activity
JN216_RS12575	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
JN216_RS12610	COG0412	Dienelactone hydrolase
JN216_RS12645	COG0604	alcohol dehydrogenase
JN216_RS12645	COG3321	synthase
JN216_RS12660	COG1028	Short-chain dehydrogenase reductase Sdr
JN216_RS12685	COG0714	Associated with various cellular activities
JN216_RS12720	COG1028	Short-chain dehydrogenase reductase Sdr
JN216_RS12745	COG2272	Belongs to the type-B carboxylesterase lipase family
JN216_RS12755	COG3265	gluconokinase activity
JN216_RS12765	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
JN216_RS12790	COG1335	isochorismatase
JN216_RS12805	COG1595	DNA-templated transcription, initiation
JN216_RS12815	COG1175	transmembrane transport
JN216_RS12820	COG0395	ABC-type sugar transport system, permease component
JN216_RS12825	COG3842	ATPase activity
JN216_RS12830	COG1752	Esterase of the alpha-beta hydrolase superfamily
JN216_RS12855	COG2837	iron assimilation
JN216_RS12865	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
JN216_RS12895	COG0667	Aldo Keto reductase
JN216_RS12905	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
JN216_RS12925	COG1960	acyl-CoA dehydrogenase activity
JN216_RS12980	COG0523	cobalamin synthesis protein
JN216_RS12985	COG1946	Acyl-CoA thioesterase
JN216_RS12995	COG2161	toxin-antitoxin pair type II binding
JN216_RS13000	COG2026	Addiction module toxin, RelE StbE family
JN216_RS13010	COG2207	Transcriptional regulator
JN216_RS13015	COG0183	Belongs to the thiolase family
JN216_RS13040	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
JN216_RS13050	COG0492	ferredoxin-NADP+ reductase activity
JN216_RS13050	COG3118	belongs to the thioredoxin family
JN216_RS13075	COG1484	DNA-dependent DNA replication
JN216_RS13080	COG4584	PFAM Integrase catalytic
JN216_RS13090	COG1484	DNA-dependent DNA replication
JN216_RS13095	COG4584	PFAM Integrase catalytic
JN216_RS13140	COG1028	Short-chain dehydrogenase reductase Sdr
JN216_RS13150	COG1028	Short-chain dehydrogenase reductase Sdr
JN216_RS13155	COG1309	transcriptional regulator
JN216_RS13170	COG0318	PFAM AMP-dependent synthetase and ligase
JN216_RS13175	COG4221	oxidoreductase activity
JN216_RS13185	COG2124	cytochrome p450
JN216_RS13190	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
JN216_RS13210	COG0477	Major facilitator Superfamily
JN216_RS13215	COG1595	DNA-templated transcription, initiation
JN216_RS13225	COG0667	Aldo Keto reductase
JN216_RS13300	COG3971	2-oxopent-4-enoate hydratase activity
JN216_RS13335	COG0545	Peptidyl-prolyl cis-trans isomerase
JN216_RS13340	COG4308	Limonene-1,2-epoxide hydrolase catalytic domain
JN216_RS13350	COG1028	Short-chain dehydrogenase reductase Sdr
JN216_RS13375	COG2301	Belongs to the HpcH HpaI aldolase family
JN216_RS13385	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
JN216_RS13400	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
JN216_RS13405	COG1643	Atp-dependent helicase
JN216_RS13415	COG1024	Enoyl-CoA hydratase
JN216_RS13435	COG1063	alcohol dehydrogenase
JN216_RS13485	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
JN216_RS13485	COG0723	plastoquinol--plastocyanin reductase activity
JN216_RS13495	COG1376	ErfK ybiS ycfS ynhG family protein
JN216_RS13510	COG3757	hydrolase, family 25
JN216_RS13515	COG0438	transferase activity, transferring glycosyl groups
JN216_RS13520	COG2226	methyltransferase
JN216_RS13550	COG3391	amine dehydrogenase activity
JN216_RS13565	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
JN216_RS13570	COG1012	belongs to the aldehyde dehydrogenase family
JN216_RS13610	COG4977	sequence-specific DNA binding
JN216_RS13620	COG1733	regulation of RNA biosynthetic process
JN216_RS13635	COG1028	Short-chain dehydrogenase reductase Sdr
JN216_RS13645	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
JN216_RS13680	COG0640	Transcriptional regulator
JN216_RS13700	COG1233	COG1233 Phytoene dehydrogenase and related
JN216_RS13710	COG1942	4-Oxalocrotonate Tautomerase
JN216_RS13740	COG1950	PFAM Membrane protein of
JN216_RS13745	COG1403	HNH endonuclease
JN216_RS13755	COG2814	Major facilitator Superfamily
JN216_RS13760	COG1546	Belongs to the CinA family
JN216_RS13760	COG1058	Belongs to the CinA family
JN216_RS13785	COG1063	alcohol dehydrogenase
JN216_RS13795	COG2070	2-Nitropropane dioxygenase
JN216_RS13835	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
JN216_RS13880	COG0174	glutamine synthetase
JN216_RS13890	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
JN216_RS13900	COG2193	ferroxidase activity
JN216_RS13910	COG1024	Enoyl-CoA hydratase
JN216_RS13935	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
JN216_RS13995	COG1804	L-carnitine dehydratase bile acid-inducible protein F
JN216_RS14000	COG1968	undecaprenyl-diphosphatase activity
JN216_RS14005	COG4221	oxidoreductase activity
JN216_RS14065	COG1252	NADH dehydrogenase
JN216_RS14085	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
JN216_RS14100	COG0318	PFAM AMP-dependent synthetase and ligase
JN216_RS14105	COG1960	acyl-CoA dehydrogenase activity
JN216_RS14110	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
JN216_RS14115	COG1253	flavin adenine dinucleotide binding
JN216_RS14120	COG1253	flavin adenine dinucleotide binding
JN216_RS14215	COG3976	FMN-binding domain protein
JN216_RS14215	COG1053	succinate dehydrogenase
JN216_RS14255	COG5651	PPE family
JN216_RS14300	COG1404	Belongs to the peptidase S8 family
JN216_RS14330	COG5651	PPE family
JN216_RS14340	COG5651	PPE family
JN216_RS14350	COG5651	PPE family
JN216_RS14390	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
JN216_RS14415	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
JN216_RS14435	COG1028	Short-chain dehydrogenase reductase Sdr
JN216_RS14440	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
JN216_RS14445	COG0022	dehydrogenase e1 component
JN216_RS14455	COG1024	Enoyl-CoA hydratase
JN216_RS14460	COG0318	PFAM AMP-dependent synthetase and ligase
JN216_RS14465	COG4638	Rieske (2fe-2S)
JN216_RS14470	COG1053	succinate dehydrogenase
JN216_RS14505	COG2813	Specifically methylates the guanine in position
JN216_RS14570	COG4221	oxidoreductase activity
JN216_RS14600	COG4221	oxidoreductase activity
JN216_RS14605	COG1804	L-carnitine dehydratase bile acid-inducible protein F
JN216_RS14610	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
JN216_RS14615	COG1028	Short-chain dehydrogenase reductase Sdr
JN216_RS14660	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
JN216_RS14680	COG0318	PFAM AMP-dependent synthetase and ligase
JN216_RS14710	COG0318	PFAM AMP-dependent synthetase and ligase
JN216_RS14715	COG2072	flavoprotein involved in K transport
JN216_RS14735	COG2030	dehydratase
JN216_RS14740	COG1960	acyl-CoA dehydrogenase activity
JN216_RS14745	COG1960	acyl-CoA dehydrogenase activity
JN216_RS14755	COG0842	Transport permease protein
JN216_RS14755	COG1716	ATPase activity
JN216_RS14755	COG1131	(ABC) transporter
JN216_RS14760	COG0657	acetylesterase activity
JN216_RS14770	COG0243	molybdopterin cofactor binding
JN216_RS14790	COG2267	carboxylic ester hydrolase activity
JN216_RS14815	COG2072	flavoprotein involved in K transport
JN216_RS14830	COG0346	lactoylglutathione lyase activity
JN216_RS14845	COG0657	acetylesterase activity
JN216_RS14865	COG1028	Short-chain dehydrogenase reductase Sdr
JN216_RS14870	COG2072	flavoprotein involved in K transport
JN216_RS14875	COG0318	PFAM AMP-dependent synthetase and ligase
JN216_RS14880	COG1960	acyl-CoA dehydrogenase activity
JN216_RS14900	COG0657	acetylesterase activity
JN216_RS14910	COG1028	Short-chain dehydrogenase reductase Sdr
JN216_RS14930	COG1053	succinate dehydrogenase
JN216_RS14940	COG1403	HNH endonuclease
JN216_RS14990	COG2271	Major facilitator Superfamily
JN216_RS14995	COG0189	ligase activity
JN216_RS14995	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
JN216_RS15025	COG1305	Transglutaminase-like
JN216_RS15035	COG1278	Cold shock
JN216_RS15100	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
JN216_RS15110	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
JN216_RS15135	COG0494	nUDIX hydrolase
JN216_RS15160	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
JN216_RS15175	COG0647	UMP catabolic process
JN216_RS15190	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
JN216_RS15195	COG2094	Belongs to the DNA glycosylase MPG family
JN216_RS15205	COG1131	(ABC) transporter
JN216_RS15220	COG1309	transcriptional regulator
JN216_RS15225	COG2835	tetraacyldisaccharide 4'-kinase activity
JN216_RS15255	COG0300	oxidoreductase activity
JN216_RS15260	COG4948	Mandelate Racemase Muconate Lactonizing
JN216_RS15265	COG3707	response regulator
JN216_RS15270	COG0488	(ABC) transporter
JN216_RS15285	COG0604	alcohol dehydrogenase
JN216_RS15285	COG0604	alcohol dehydrogenase
JN216_RS15285	COG3321	synthase
JN216_RS15285	COG3321	synthase
JN216_RS15290	COG0604	alcohol dehydrogenase
JN216_RS15290	COG3321	synthase
JN216_RS15295	COG3321	synthase
JN216_RS15295	COG0604	alcohol dehydrogenase
JN216_RS15305	COG0165	Argininosuccinate lyase
JN216_RS15320	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
JN216_RS15335	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
JN216_RS15340	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
JN216_RS15345	COG0072	phenylalanine-tRNA ligase activity
JN216_RS15345	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JN216_RS15350	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
JN216_RS15380	COG0291	Belongs to the bacterial ribosomal protein bL35 family
JN216_RS15405	COG1309	transcriptional regulator
JN216_RS15415	COG2890	protein-(glutamine-N5) methyltransferase activity
JN216_RS15480	COG1716	ATPase activity
JN216_RS15480	COG1131	(ABC) transporter
JN216_RS15480	COG0842	Transport permease protein
JN216_RS15495	COG2201	protein-glutamate methylesterase activity
JN216_RS15510	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
JN216_RS15520	COG0237	dephospho-CoA kinase activity
JN216_RS15520	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
JN216_RS15530	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
JN216_RS15580	COG1271	oxidase subunit
JN216_RS15585	COG1294	oxidase, subunit
JN216_RS15590	COG4988	ABC transporter
JN216_RS15595	COG1132	(ABC) transporter
JN216_RS15610	COG1946	Acyl-CoA thioesterase
JN216_RS15650	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
JN216_RS15660	COG0387	Pfam Sodium calcium exchanger
JN216_RS15665	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
JN216_RS15675	COG0483	inositol monophosphate 1-phosphatase activity
JN216_RS15685	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
JN216_RS15690	COG0131	Imidazoleglycerol-phosphate dehydratase
JN216_RS15700	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
JN216_RS15710	COG0157	Belongs to the NadC ModD family
JN216_RS15770	COG5002	protein histidine kinase activity
JN216_RS15775	COG0668	transmembrane transport
JN216_RS15800	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
JN216_RS15810	COG0791	NLP P60 protein
JN216_RS15810	COG3883	PFAM NLP P60 protein
JN216_RS15850	COG0671	phosphoesterase, PA-phosphatase related
JN216_RS15880	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
JN216_RS15905	COG0300	oxidoreductase activity
JN216_RS15915	COG2346	COG2346, Truncated hemoglobins
JN216_RS15935	COG0252	asparaginase activity
JN216_RS15945	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
JN216_RS15955	COG2070	2-Nitropropane dioxygenase
JN216_RS16025	COG2755	lipolytic protein G-D-S-L family
JN216_RS16025	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
JN216_RS16035	COG4584	PFAM Integrase catalytic
JN216_RS16040	COG1484	DNA-dependent DNA replication
JN216_RS16055	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
JN216_RS16060	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
JN216_RS16080	COG4221	oxidoreductase activity
JN216_RS16130	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
JN216_RS16180	COG2205	protein histidine kinase activity
JN216_RS16185	COG0745	RESPONSE REGULATOR receiver
JN216_RS16220	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
JN216_RS16225	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
JN216_RS16240	COG2304	oxidoreductase activity
JN216_RS16250	COG0714	Associated with various cellular activities
JN216_RS16260	COG0791	NLP P60 protein
JN216_RS16260	COG3883	PFAM NLP P60 protein
JN216_RS16270	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
JN216_RS16275	COG1309	transcriptional regulator
JN216_RS16285	COG0488	(ABC) transporter
JN216_RS16295	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
JN216_RS16300	COG1960	acyl-CoA dehydrogenase activity
JN216_RS16330	COG2151	metal-sulfur cluster biosynthetic enzyme
JN216_RS16335	COG0822	iron-sulfur transferase activity
JN216_RS16345	COG0396	ATPase activity
JN216_RS16370	COG1131	(ABC) transporter
JN216_RS16405	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
JN216_RS16430	COG0123	including yeast histone deacetylase and acetoin utilization protein
JN216_RS16435	COG0667	Aldo Keto reductase
JN216_RS16440	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
JN216_RS16480	COG0318	PFAM AMP-dependent synthetase and ligase
JN216_RS16485	COG0657	acetylesterase activity
JN216_RS16490	COG1403	HNH endonuclease
JN216_RS16510	COG1660	Displays ATPase and GTPase activities
JN216_RS16515	COG0322	excinuclease ABC activity
JN216_RS16540	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
JN216_RS16605	COG0657	acetylesterase activity
JN216_RS16635	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
JN216_RS16660	COG0505	Belongs to the CarA family
JN216_RS16680	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
JN216_RS16690	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
JN216_RS16720	COG2188	Transcriptional regulator
JN216_RS16765	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
JN216_RS16790	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
JN216_RS16795	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
JN216_RS16800	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
JN216_RS16810	COG0432	Pfam Uncharacterised protein family UPF0047
JN216_RS16875	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
JN216_RS16895	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
JN216_RS16900	COG0235	Class ii aldolase
JN216_RS16905	COG1396	sequence-specific DNA binding
JN216_RS16940	COG1403	HNH endonuclease
JN216_RS16945	COG0124	histidyl-tRNA synthetase
JN216_RS16950	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JN216_RS16965	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
JN216_RS16970	COG0747	negative chemotaxis
JN216_RS16975	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
JN216_RS16995	COG3320	Male sterility
JN216_RS16995	COG1022	Amp-dependent synthetase and ligase
JN216_RS17045	COG3766	membrane
JN216_RS17065	COG1946	Acyl-CoA thioesterase
JN216_RS17090	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
JN216_RS17115	COG0667	Aldo Keto reductase
JN216_RS17120	COG4762	Protein conserved in bacteria
JN216_RS17135	COG2070	2-Nitropropane dioxygenase
JN216_RS17175	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
JN216_RS17185	COG3485	protocatechuate 3,4-dioxygenase
JN216_RS17225	COG1414	Transcriptional regulator
JN216_RS17235	COG1309	transcriptional regulator
JN216_RS17240	COG1366	Belongs to the anti-sigma-factor antagonist family
JN216_RS17245	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
JN216_RS17255	COG0753	catalase activity
JN216_RS17260	COG1028	Short-chain dehydrogenase reductase Sdr
JN216_RS17280	COG1024	Enoyl-CoA hydratase
JN216_RS17330	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
JN216_RS17415	COG1511	domain protein
JN216_RS17440	COG4689	acetoacetate decarboxylase
JN216_RS17475	COG1309	transcriptional regulator
JN216_RS17495	COG1012	belongs to the aldehyde dehydrogenase family
JN216_RS17555	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
JN216_RS17565	COG3253	May function as heme-dependent peroxidase
JN216_RS17605	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
JN216_RS17610	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
JN216_RS17615	COG0531	amino acid
JN216_RS17620	COG0569	domain protein
JN216_RS17670	COG0483	inositol monophosphate 1-phosphatase activity
JN216_RS17765	COG1388	LysM domain
JN216_RS17780	COG1960	acyl-CoA dehydrogenase activity
JN216_RS17785	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
JN216_RS17795	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
JN216_RS17810	COG1196	nuclear chromosome segregation
JN216_RS17820	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
JN216_RS17860	COG4308	Limonene-1,2-epoxide hydrolase catalytic domain
JN216_RS17875	COG1842	Phage shock protein A
JN216_RS17890	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
JN216_RS17895	COG1674	ftsk spoiiie
JN216_RS17920	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
JN216_RS17930	COG3214	Protein conserved in bacteria
JN216_RS17955	COG1960	acyl-CoA dehydrogenase activity
JN216_RS17960	COG1960	acyl-CoA dehydrogenase activity
JN216_RS17965	COG1028	Short-chain dehydrogenase reductase Sdr
JN216_RS17975	COG4770	biotin carboxylase activity
JN216_RS17980	COG0318	PFAM AMP-dependent synthetase and ligase
JN216_RS18000	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
JN216_RS18050	COG0686	Belongs to the AlaDH PNT family
JN216_RS18065	COG1185	polyribonucleotide nucleotidyltransferase activity
JN216_RS18095	COG1960	acyl-CoA dehydrogenase activity
JN216_RS18100	COG0183	Belongs to the thiolase family
JN216_RS18105	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
JN216_RS18110	COG2977	Belongs to the P-Pant transferase superfamily
JN216_RS18115	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
JN216_RS18140	COG1024	Enoyl-CoA hydratase
JN216_RS18150	COG0534	Mate efflux family protein
JN216_RS18155	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
JN216_RS18165	COG0481	GTPase activity
JN216_RS18205	COG1648	precorrin-2 dehydrogenase activity
JN216_RS18205	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
JN216_RS18230	COG0579	oxidoreductase
JN216_RS18245	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
JN216_RS18260	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
JN216_RS18275	COG1028	Short-chain dehydrogenase reductase Sdr
JN216_RS18285	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
JN216_RS18300	COG1492	cobalamin metabolic process
JN216_RS18325	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
JN216_RS18330	COG0750	zinc metalloprotease
JN216_RS18335	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
JN216_RS18355	COG0820	rRNA (adenine-C2-)-methyltransferase activity
JN216_RS18360	COG0575	Belongs to the CDS family
JN216_RS18380	COG0745	RESPONSE REGULATOR receiver
JN216_RS18400	COG1028	Short-chain dehydrogenase reductase Sdr
JN216_RS18420	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
JN216_RS18445	COG0154	amidase activity
JN216_RS18455	COG0052	Belongs to the universal ribosomal protein uS2 family
JN216_RS18495	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
JN216_RS18505	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
JN216_RS18520	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
JN216_RS18540	COG0336	Belongs to the RNA methyltransferase TrmD family
JN216_RS18555	COG0228	four-way junction DNA binding
JN216_RS18565	COG1686	Belongs to the peptidase S11 family
JN216_RS18615	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
JN216_RS18635	COG1196	nuclear chromosome segregation
JN216_RS18650	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
JN216_RS18675	COG0701	Predicted permease
JN216_RS18680	COG0028	Belongs to the TPP enzyme family
JN216_RS18690	COG0742	ribosomal rna small subunit methyltransferase
JN216_RS18705	COG0657	acetylesterase activity
JN216_RS18725	COG1461	Dihydroxyacetone kinase
JN216_RS18770	COG3321	synthase
JN216_RS18770	COG0604	alcohol dehydrogenase
JN216_RS18790	COG1181	Belongs to the D-alanine--D-alanine ligase family
JN216_RS18795	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
JN216_RS18800	COG1920	GTP binding
JN216_RS18805	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
JN216_RS18850	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
JN216_RS18855	COG0179	Fumarylacetoacetate (FAA) hydrolase
JN216_RS18860	COG2271	Major facilitator Superfamily
JN216_RS18865	COG2271	Major facilitator Superfamily
JN216_RS18870	COG0473	3-isopropylmalate dehydrogenase activity
JN216_RS18885	COG0655	NAD(P)H dehydrogenase (quinone) activity
JN216_RS18900	COG0028	Belongs to the TPP enzyme family
JN216_RS18910	COG2259	Doxx family
JN216_RS18930	COG1192	Involved in chromosome partitioning
JN216_RS18935	COG0205	6-phosphofructokinase activity
JN216_RS18980	COG0626	cystathionine gamma-synthase activity
JN216_RS19030	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
JN216_RS19080	COG0142	geranyltranstransferase activity
JN216_RS19110	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
JN216_RS19150	COG1819	glycosyl
JN216_RS19155	COG1304	FMN binding
JN216_RS19160	COG2409	Drug exporters of the RND superfamily
JN216_RS19170	COG0415	Belongs to the DNA photolyase family
JN216_RS19180	COG0110	maltose O-acetyltransferase activity
JN216_RS19185	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
JN216_RS19210	COG1024	Enoyl-CoA hydratase
JN216_RS19220	COG1119	ATPase activity
JN216_RS19230	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
JN216_RS19265	COG1309	transcriptional regulator
JN216_RS19275	COG2072	flavoprotein involved in K transport
JN216_RS19280	COG1309	transcriptional regulator
JN216_RS19350	COG2186	Transcriptional regulator
JN216_RS19365	COG1960	acyl-CoA dehydrogenase activity
JN216_RS19375	COG1793	dna ligase
JN216_RS19380	COG0443	Heat shock 70 kDa protein
JN216_RS19390	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JN216_RS19395	COG0183	Belongs to the thiolase family
JN216_RS19400	COG1024	Enoyl-CoA hydratase
JN216_RS19405	COG1804	L-carnitine dehydratase bile acid-inducible protein F
JN216_RS19430	COG1028	Short-chain dehydrogenase reductase Sdr
JN216_RS19445	COG2076	Multidrug Resistance protein
JN216_RS19495	COG4638	Rieske (2fe-2S)
JN216_RS19500	COG1028	Short-chain dehydrogenase reductase Sdr
JN216_RS19525	COG4638	Rieske (2fe-2S)
JN216_RS19540	COG0318	PFAM AMP-dependent synthetase and ligase
JN216_RS19555	COG3654	unkown
JN216_RS19575	COG0477	Major facilitator Superfamily
JN216_RS19585	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
JN216_RS19590	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
JN216_RS19610	COG2301	Belongs to the HpcH HpaI aldolase family
JN216_RS19625	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
JN216_RS19660	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
JN216_RS19720	COG4638	Rieske (2fe-2S)
JN216_RS19730	COG1131	(ABC) transporter
JN216_RS19730	COG1716	ATPase activity
JN216_RS19730	COG0842	Transport permease protein
JN216_RS19740	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
JN216_RS19740	COG2755	lipolytic protein G-D-S-L family
JN216_RS19790	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
JN216_RS19795	COG2177	Part of the ABC transporter FtsEX involved in
JN216_RS19800	COG2884	Cell division ATP-binding protein ftsE
JN216_RS19810	COG0668	transmembrane transport
JN216_RS19820	COG0493	'glutamate synthase
JN216_RS19860	COG0483	inositol monophosphate 1-phosphatase activity
JN216_RS19870	COG1960	acyl-CoA dehydrogenase activity
JN216_RS19875	COG0667	Aldo Keto reductase
JN216_RS19880	COG0604	alcohol dehydrogenase
JN216_RS19900	COG1804	L-carnitine dehydratase bile acid-inducible protein F
JN216_RS19905	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
JN216_RS19915	COG1960	acyl-CoA dehydrogenase activity
JN216_RS19930	COG2353	YceI-like domain
JN216_RS19950	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
JN216_RS19970	COG1034	ATP synthesis coupled electron transport
JN216_RS19975	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
JN216_RS19990	COG0713	ATP synthesis coupled electron transport
JN216_RS20020	COG0714	Associated with various cellular activities
JN216_RS20075	COG0297	glycogen (starch) synthase activity
JN216_RS20085	COG4584	PFAM Integrase catalytic
JN216_RS20090	COG1484	DNA-dependent DNA replication
JN216_RS20135	COG3237	CsbD-like
JN216_RS20145	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
JN216_RS20145	COG2111	Na H antiporter
JN216_RS20150	COG1006	Multisubunit Na H antiporter MnhC subunit
JN216_RS20165	COG1320	monovalent cation:proton antiporter activity
JN216_RS20170	COG2212	antiporter activity
JN216_RS20190	COG0028	Belongs to the TPP enzyme family
JN216_RS20195	COG1573	uracil-dna glycosylase
JN216_RS20250	COG0789	Transcriptional regulator
JN216_RS20260	COG3707	response regulator
JN216_RS20270	COG2197	response regulator
JN216_RS20290	COG1028	Short-chain dehydrogenase reductase Sdr
JN216_RS20315	COG1063	alcohol dehydrogenase
JN216_RS20375	COG0386	Belongs to the glutathione peroxidase family
JN216_RS20400	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
JN216_RS20410	COG0783	Belongs to the Dps family
JN216_RS20420	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
JN216_RS20470	COG3480	Lon protease (S16) C-terminal proteolytic domain
JN216_RS20485	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
JN216_RS20510	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
JN216_RS20530	COG0596	Alpha beta hydrolase
JN216_RS20575	COG0513	Belongs to the DEAD box helicase family
JN216_RS20590	COG0406	alpha-ribazole phosphatase activity
JN216_RS20625	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
JN216_RS20645	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
JN216_RS20650	COG1063	alcohol dehydrogenase
JN216_RS20665	COG1028	Short-chain dehydrogenase reductase Sdr
JN216_RS20675	COG1028	Short-chain dehydrogenase reductase Sdr
JN216_RS20695	COG2135	peptidase activity
JN216_RS20700	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
JN216_RS20705	COG1162	GTPase activity
JN216_RS20710	COG1733	regulation of RNA biosynthetic process
JN216_RS20715	COG0183	Belongs to the thiolase family
JN216_RS20730	COG1309	transcriptional regulator
JN216_RS20765	COG2020	methyltransferase activity
JN216_RS20770	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
JN216_RS20780	COG0653	protein targeting
JN216_RS20785	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
JN216_RS20795	COG5401	PFAM Sporulation and spore germination
JN216_RS20800	COG5000	phosphorelay sensor kinase activity
JN216_RS20800	COG5002	protein histidine kinase activity
JN216_RS20815	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
JN216_RS20835	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
JN216_RS20840	COG0531	amino acid
JN216_RS20845	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
JN216_RS20850	COG1482	cell wall glycoprotein biosynthetic process
JN216_RS20860	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
JN216_RS20900	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
JN216_RS20915	COG1316	TRANSCRIPTIONal
JN216_RS20940	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
JN216_RS20945	COG1804	L-carnitine dehydratase bile acid-inducible protein F
JN216_RS20985	COG0784	Response regulator, receiver
JN216_RS20990	COG4251	negative regulation of phosphorylation
JN216_RS21005	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
JN216_RS21010	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
JN216_RS21030	COG1053	succinate dehydrogenase
JN216_RS21035	COG0318	PFAM AMP-dependent synthetase and ligase
JN216_RS21050	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
JN216_RS21060	COG0424	maF-like protein
JN216_RS21075	COG4770	biotin carboxylase activity
JN216_RS21080	COG1366	Belongs to the anti-sigma-factor antagonist family
JN216_RS21110	COG1522	sequence-specific DNA binding
JN216_RS21120	COG1012	belongs to the aldehyde dehydrogenase family
JN216_RS21125	COG1309	transcriptional regulator
JN216_RS21130	COG1201	RNA secondary structure unwinding
JN216_RS21165	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
JN216_RS21175	COG0564	pseudouridine synthase activity
JN216_RS21180	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
JN216_RS21195	COG0657	acetylesterase activity
JN216_RS21200	COG1473	amidohydrolase
JN216_RS21200	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
JN216_RS21205	COG1473	amidohydrolase
JN216_RS21220	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
JN216_RS21225	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
JN216_RS21230	COG3511	phospholipase C
JN216_RS21240	COG2304	oxidoreductase activity
JN216_RS21245	COG2304	oxidoreductase activity
JN216_RS21280	COG2009	succinate dehydrogenase
JN216_RS21290	COG1053	succinate dehydrogenase
JN216_RS21295	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
JN216_RS21310	COG1595	DNA-templated transcription, initiation
JN216_RS21315	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
JN216_RS21325	COG1686	Belongs to the peptidase S11 family
JN216_RS21330	COG2814	Major facilitator Superfamily
JN216_RS21345	COG1295	ribonuclease BN
JN216_RS21370	COG2873	o-acetylhomoserine
JN216_RS21390	COG1403	HNH endonuclease
JN216_RS21420	COG1131	(ABC) transporter
JN216_RS21420	COG1716	ATPase activity
JN216_RS21420	COG0842	Transport permease protein
JN216_RS21425	COG1357	PFAM Pentapeptide repeats (8 copies)
JN216_RS21440	COG2018	Roadblock/LC7 domain
JN216_RS21445	COG5002	protein histidine kinase activity
JN216_RS21455	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
JN216_RS21470	COG0587	DNA-directed DNA polymerase activity
JN216_RS21475	COG1877	trehalose-phosphatase activity
JN216_RS21475	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JN216_RS21480	COG2030	dehydratase
JN216_RS21485	COG0406	alpha-ribazole phosphatase activity
JN216_RS21490	COG4221	oxidoreductase activity
JN216_RS21495	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
JN216_RS21535	COG0519	Catalyzes the synthesis of GMP from XMP
JN216_RS21535	COG0518	GMP synthase (glutamine-hydrolyzing) activity
JN216_RS21625	COG2032	superoxide dismutase activity
JN216_RS21650	COG0459	protein refolding
JN216_RS21665	COG0456	acetyltransferase
JN216_RS21670	COG0456	acetyltransferase
JN216_RS21670	COG1214	PFAM Peptidase M22, glycoprotease
JN216_RS21675	COG0802	atpase or kinase
JN216_RS21690	COG0076	glutamate decarboxylase activity
JN216_RS21710	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
JN216_RS21730	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JN216_RS21760	COG4842	Belongs to the WXG100 family
JN216_RS21765	COG4842	Belongs to the WXG100 family
JN216_RS21775	COG1674	ftsk spoiiie
JN216_RS21785	COG1404	Belongs to the peptidase S8 family
JN216_RS21825	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
JN216_RS21830	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
JN216_RS21835	COG0257	Belongs to the bacterial ribosomal protein bL36 family
JN216_RS21840	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
JN216_RS21850	COG2205	protein histidine kinase activity
JN216_RS21905	COG3794	PFAM blue (type 1) copper domain protein
JN216_RS21930	COG1960	acyl-CoA dehydrogenase activity
JN216_RS21945	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
JN216_RS21960	COG0028	Belongs to the TPP enzyme family
JN216_RS21965	COG0577	efflux transmembrane transporter activity
JN216_RS21965	COG1136	(ABC) transporter
JN216_RS21970	COG0577	efflux transmembrane transporter activity
JN216_RS21975	COG2226	methyltransferase
JN216_RS21985	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
JN216_RS22005	COG0563	adenylate kinase activity
JN216_RS22015	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
JN216_RS22045	COG1063	alcohol dehydrogenase
JN216_RS22050	COG4221	oxidoreductase activity
JN216_RS22070	COG0616	signal peptide processing
JN216_RS22075	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JN216_RS22090	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
JN216_RS22095	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
JN216_RS22120	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
JN216_RS22135	COG1262	PFAM Formylglycine-generating sulfatase enzyme
JN216_RS22145	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
JN216_RS22235	COG0535	radical SAM domain protein
JN216_RS22260	COG0483	inositol monophosphate 1-phosphatase activity
JN216_RS22270	COG1028	Short-chain dehydrogenase reductase Sdr
JN216_RS22295	COG0049	tRNA binding
JN216_RS22305	COG1309	transcriptional regulator
JN216_RS22320	COG1024	Enoyl-CoA hydratase
JN216_RS22335	COG1960	acyl-CoA dehydrogenase activity
JN216_RS22375	COG0222	ribosome binding
JN216_RS22410	COG2318	DinB family
JN216_RS22425	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
JN216_RS22430	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
JN216_RS22440	COG4941	Belongs to the sigma-70 factor family
JN216_RS22460	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
JN216_RS22470	COG2030	dehydratase
JN216_RS22475	COG2030	dehydratase
JN216_RS22480	COG2030	dehydratase
JN216_RS22505	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JN216_RS22520	COG0243	molybdopterin cofactor binding
JN216_RS22530	COG1752	Esterase of the alpha-beta hydrolase superfamily
JN216_RS22540	COG2226	methyltransferase
JN216_RS22545	COG0778	Nitroreductase
JN216_RS22550	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
JN216_RS22555	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
JN216_RS22560	COG1074	ATP-dependent DNA helicase activity
JN216_RS22590	COG3537	Alpha-1,2-mannosidase
JN216_RS22610	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
JN216_RS22645	COG2124	cytochrome p450
JN216_RS22650	COG2826	transposase and inactivated derivatives, IS30 family
JN216_RS22660	COG1914	H( )-stimulated, divalent metal cation uptake system
JN216_RS22665	COG0243	molybdopterin cofactor binding
JN216_RS22685	COG2072	flavoprotein involved in K transport
JN216_RS22695	COG0659	secondary active sulfate transmembrane transporter activity
JN216_RS22705	COG0501	Belongs to the peptidase M48B family
JN216_RS22710	COG0142	geranyltranstransferase activity
JN216_RS22725	COG2226	methyltransferase
JN216_RS22730	COG0300	oxidoreductase activity
JN216_RS22755	COG4948	Mandelate Racemase Muconate Lactonizing
JN216_RS22760	COG1228	amidohydrolase
JN216_RS22785	COG0318	PFAM AMP-dependent synthetase and ligase
JN216_RS22795	COG0667	Aldo Keto reductase
JN216_RS22810	COG4221	oxidoreductase activity
JN216_RS22820	COG0306	phosphate transporter
JN216_RS22865	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
JN216_RS22870	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
JN216_RS22895	COG2894	cell division
JN216_RS22900	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
JN216_RS22910	COG0785	Cytochrome C biogenesis protein
JN216_RS22920	COG0406	alpha-ribazole phosphatase activity
JN216_RS22940	COG4948	Mandelate Racemase Muconate Lactonizing
JN216_RS22945	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
JN216_RS22955	COG1113	amino acid transport
JN216_RS22965	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JN216_RS22975	COG2755	lipolytic protein G-D-S-L family
JN216_RS22975	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
JN216_RS22980	COG2755	lipolytic protein G-D-S-L family
JN216_RS22990	COG1366	Belongs to the anti-sigma-factor antagonist family
JN216_RS23060	COG2030	dehydratase
JN216_RS23130	COG0588	phosphoglycerate mutase activity
JN216_RS23140	COG0438	transferase activity, transferring glycosyl groups
JN216_RS23180	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
JN216_RS23205	COG2733	membrane
JN216_RS23220	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
JN216_RS23280	COG1505	serine-type exopeptidase activity
JN216_RS23290	COG1024	Enoyl-CoA hydratase
JN216_RS23300	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
JN216_RS23345	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
JN216_RS23365	COG4221	oxidoreductase activity
JN216_RS23395	COG1028	Short-chain dehydrogenase reductase Sdr
JN216_RS23405	COG0738	Major facilitator superfamily
JN216_RS23420	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
JN216_RS23470	COG2032	superoxide dismutase activity
JN216_RS23485	COG0242	peptide deformylase activity
JN216_RS23515	COG3707	response regulator
JN216_RS23585	COG1088	dTDP-glucose 4,6-dehydratase activity
JN216_RS23590	COG2234	aminopeptidase activity
JN216_RS23595	COG2234	aminopeptidase activity
JN216_RS23635	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
JN216_RS23635	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
JN216_RS23655	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JN216_RS23670	COG2826	transposase and inactivated derivatives, IS30 family
JN216_RS23675	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
JN216_RS23690	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JN216_RS23710	COG1028	Short-chain dehydrogenase reductase Sdr
JN216_RS23715	COG1960	acyl-CoA dehydrogenase activity
JN216_RS23735	COG1252	NADH dehydrogenase
JN216_RS23745	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
JN216_RS23765	COG0406	alpha-ribazole phosphatase activity
JN216_RS23775	COG1994	Peptidase M50
JN216_RS23815	COG2826	transposase and inactivated derivatives, IS30 family
JN216_RS23850	COG0542	response to heat
JN216_RS23870	COG0789	Transcriptional regulator
JN216_RS23875	COG0484	heat shock protein binding
JN216_RS23880	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
JN216_RS23915	COG2814	Major facilitator Superfamily
JN216_RS23930	COG0247	lactate metabolic process
JN216_RS23930	COG2181	nitrate reductase activity
JN216_RS23960	COG2226	methyltransferase
JN216_RS23965	COG0477	Major facilitator Superfamily
JN216_RS23975	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
JN216_RS24010	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
JN216_RS24110	COG4584	PFAM Integrase catalytic
JN216_RS24115	COG1484	DNA-dependent DNA replication
JN216_RS24145	COG1376	ErfK ybiS ycfS ynhG family protein
JN216_RS24165	COG0246	Mannitol dehydrogenase
JN216_RS24170	COG1070	Carbohydrate kinase
JN216_RS24210	COG2130	NADP-dependent
JN216_RS24270	COG0778	Nitroreductase
JN216_RS24275	COG1368	sulfuric ester hydrolase activity
JN216_RS24295	COG1404	Belongs to the peptidase S8 family
JN216_RS24345	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
JN216_RS24350	COG0254	rRNA binding
JN216_RS24365	COG0267	Belongs to the bacterial ribosomal protein bL33 family
JN216_RS24370	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
JN216_RS24375	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
JN216_RS24415	COG0346	lactoylglutathione lyase activity
JN216_RS24430	COG1960	acyl-CoA dehydrogenase activity
JN216_RS24440	COG0318	PFAM AMP-dependent synthetase and ligase
JN216_RS24450	COG2223	nitrite transmembrane transporter activity
JN216_RS24465	COG1984	allophanate hydrolase subunit 2
JN216_RS24495	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
JN216_RS24495	COG2146	nitrite reductase [NAD(P)H] activity
JN216_RS24520	COG1053	succinate dehydrogenase
JN216_RS24545	COG1960	acyl-CoA dehydrogenase activity
JN216_RS24560	COG0183	Belongs to the thiolase family
JN216_RS24565	COG1028	Short-chain dehydrogenase reductase Sdr
JN216_RS24570	COG2030	dehydratase
JN216_RS24590	COG1472	Belongs to the glycosyl hydrolase 3 family
JN216_RS24605	COG4981	capsule polysaccharide biosynthetic process
JN216_RS24615	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
JN216_RS24675	COG0028	Belongs to the TPP enzyme family
JN216_RS24680	COG1012	belongs to the aldehyde dehydrogenase family
JN216_RS24685	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
JN216_RS24740	COG0586	Pfam SNARE associated Golgi protein
JN216_RS24760	COG1309	transcriptional regulator
JN216_RS24770	COG0318	PFAM AMP-dependent synthetase and ligase
JN216_RS24785	COG1024	Enoyl-CoA hydratase
JN216_RS24795	COG0657	acetylesterase activity
JN216_RS24805	COG2267	carboxylic ester hydrolase activity
JN216_RS24815	COG1228	amidohydrolase
JN216_RS24840	COG1024	Enoyl-CoA hydratase
JN216_RS24850	COG2203	Gaf domain
JN216_RS24850	COG2199	diguanylate cyclase activity
JN216_RS24855	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
JN216_RS24870	COG0220	tRNA (guanine-N7-)-methyltransferase activity
JN216_RS24880	COG2409	Drug exporters of the RND superfamily
JN216_RS24920	COG3590	peptidase
JN216_RS24925	COG0243	molybdopterin cofactor binding
JN216_RS24940	COG2814	Major facilitator Superfamily
JN216_RS24945	COG1937	Protein conserved in bacteria
JN216_RS24950	COG0129	dihydroxy-acid dehydratase activity
JN216_RS24965	COG4122	O-methyltransferase activity
JN216_RS24975	COG1472	Belongs to the glycosyl hydrolase 3 family
JN216_RS24990	COG2267	carboxylic ester hydrolase activity
JN216_RS25030	COG3619	membrane
JN216_RS25045	COG1714	RDD family
JN216_RS25060	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
JN216_RS25085	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
JN216_RS25090	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
JN216_RS25100	COG1802	Transcriptional regulator
JN216_RS25120	COG0657	acetylesterase activity
JN216_RS25145	COG1063	alcohol dehydrogenase
JN216_RS25150	COG2124	cytochrome p450
JN216_RS25180	COG1960	acyl-CoA dehydrogenase activity
JN216_RS25185	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JN216_RS25215	COG0277	FAD linked oxidase domain protein
JN216_RS25235	COG1309	transcriptional regulator
JN216_RS25265	COG1960	acyl-CoA dehydrogenase activity
JN216_RS25270	COG2365	Tyrosine phosphatase family
JN216_RS25275	COG1028	Short-chain dehydrogenase reductase Sdr
JN216_RS25280	COG1012	belongs to the aldehyde dehydrogenase family
JN216_RS25305	COG1741	Belongs to the pirin family
JN216_RS25310	COG0783	Belongs to the Dps family
JN216_RS25330	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
JN216_RS25345	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
JN216_RS25360	COG3585	molybdate ion transport
JN216_RS25365	COG0596	Alpha beta hydrolase
JN216_RS25385	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JN216_RS25420	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JN216_RS25430	COG3546	catalase activity
JN216_RS25465	COG0842	Transport permease protein
JN216_RS25465	COG1129	ABC transporter
JN216_RS25485	COG3281	Trehalose synthase
JN216_RS25495	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
JN216_RS25515	COG0028	Belongs to the TPP enzyme family
JN216_RS25520	COG0583	DNA-binding transcription factor activity
JN216_RS25525	COG1376	ErfK ybiS ycfS ynhG family protein
JN216_RS25560	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
JN216_RS25560	COG2755	lipolytic protein G-D-S-L family
JN216_RS25570	COG0028	Belongs to the TPP enzyme family
JN216_RS25580	COG1028	Short-chain dehydrogenase reductase Sdr
JN216_RS25585	COG2072	flavoprotein involved in K transport
JN216_RS25595	COG1028	Short-chain dehydrogenase reductase Sdr
JN216_RS25600	COG3386	PFAM SMP-30 Gluconolaconase
JN216_RS25610	COG0318	PFAM AMP-dependent synthetase and ligase
JN216_RS25620	COG0318	PFAM AMP-dependent synthetase and ligase
JN216_RS25665	COG0318	PFAM AMP-dependent synthetase and ligase
JN216_RS25680	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
JN216_RS25700	COG2226	methyltransferase
JN216_RS25710	COG0300	oxidoreductase activity
JN216_RS25775	COG1028	Short-chain dehydrogenase reductase Sdr
JN216_RS25780	COG2072	flavoprotein involved in K transport
JN216_RS25805	COG0583	DNA-binding transcription factor activity
JN216_RS25825	COG1028	Short-chain dehydrogenase reductase Sdr
JN216_RS25830	COG1028	Short-chain dehydrogenase reductase Sdr
JN216_RS25845	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
JN216_RS25865	COG1309	transcriptional regulator
JN216_RS25875	COG1028	Short-chain dehydrogenase reductase Sdr
JN216_RS25880	COG0318	PFAM AMP-dependent synthetase and ligase
JN216_RS25905	COG1804	L-carnitine dehydratase bile acid-inducible protein F
JN216_RS25930	COG1960	acyl-CoA dehydrogenase activity
JN216_RS25935	COG1309	transcriptional regulator
JN216_RS25955	COG0148	phosphopyruvate hydratase activity
JN216_RS25965	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
JN216_RS25970	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
JN216_RS25970	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
JN216_RS25970	COG0649	NAD binding
JN216_RS25975	COG0651	ATP synthesis coupled electron transport
JN216_RS25985	COG0650	Formate hydrogenlyase subunit 4
JN216_RS25990	COG1051	belongs to the nudix hydrolase family
JN216_RS26005	COG1484	DNA-dependent DNA replication
JN216_RS26010	COG4584	PFAM Integrase catalytic
JN216_RS26015	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
JN216_RS26020	COG1193	negative regulation of DNA recombination
JN216_RS26095	COG2046	Belongs to the sulfate adenylyltransferase family
JN216_RS26100	COG1993	acr, cog1993
JN216_RS26120	COG0529	Catalyzes the synthesis of activated sulfate
JN216_RS26150	COG0589	response to stress
JN216_RS26205	COG3588	fructose-bisphosphate aldolase
JN216_RS26240	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
JN216_RS26245	COG4638	Rieske (2fe-2S)
JN216_RS26255	COG2197	response regulator
JN216_RS26260	COG4585	Histidine kinase
JN216_RS26275	COG1674	ftsk spoiiie
JN216_RS26320	COG0617	tRNA 3'-terminal CCA addition
JN216_RS26355	COG1595	DNA-templated transcription, initiation
JN216_RS26375	COG3409	Peptidoglycan-binding domain 1 protein
JN216_RS26375	COG0860	N-Acetylmuramoyl-L-alanine amidase
JN216_RS26390	COG1192	Involved in chromosome partitioning
JN216_RS26395	COG0357	Ribosomal RNA small subunit methyltransferase G
JN216_RS26405	COG0706	membrane insertase activity
JN216_RS26410	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
JN216_RS26515	COG0477	Major facilitator Superfamily
JN216_RS26520	COG2161	toxin-antitoxin pair type II binding