locus-tag class description G6N24_RS00050 ENOG4105CIJ rieske 2fe-2S domain-containing protein G6N24_RS00055 ENOG4108Z0R Transferase G6N24_RS00090 ENOG4105DYW oxidoreductase G6N24_RS00105 ENOG4106YT9 Enoyl-CoA hydratase G6N24_RS00135 ENOG4105J5T Amp-dependent synthetase and ligase G6N24_RS00140 ENOG4108KC2 acyl-Coa dehydrogenase G6N24_RS00145 ENOG4105X7H acyl-CoA dehydrogenase G6N24_RS00225 ENOG4105VUN Transcriptional regulator G6N24_RS00230 ENOG4105NQG DoxX G6N24_RS00235 ENOG4108T5I Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) G6N24_RS00240 ENOG4105C4B ABC transporter, permease G6N24_RS00255 ENOG4106KE4 Dehydrogenase G6N24_RS00265 ENOG4107TB5 TRANSCRIPTIONal G6N24_RS00285 ENOG4105C0R drug resistance transporter emrb qaca subfamily G6N24_RS00295 ENOG4106WR0 acetolactate synthase (large subunit) G6N24_RS00300 ENOG4105DF3 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity) G6N24_RS00320 ENOG4105GCF PGAM G6N24_RS00365 ENOG4105CK6 Two component transcriptional regulator (Winged helix family G6N24_RS00370 ENOG4105BZU Histidine kinase G6N24_RS00400 ENOG4106IJN integrase catalytic domain-containing protein G6N24_RS00405 ENOG4105F5W AtP-binding protein G6N24_RS00420 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase G6N24_RS00445 ENOG4105EMU Dehydrogenase G6N24_RS00460 ENOG4105C26 Dehydrogenase G6N24_RS00490 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) G6N24_RS00510 ENOG4105C83 adenylosuccinate lyase G6N24_RS00525 ENOG4105C8V SAICAR synthetase G6N24_RS00545 ENOG4105C0R drug resistance transporter emrb qaca subfamily G6N24_RS00560 ENOG4107XDQ Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) G6N24_RS00565 ENOG410839H phosphoribosylformylglycinamidine synthase G6N24_RS00585 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone G6N24_RS00590 ENOG4105CZE histidine utilization repressor G6N24_RS00595 ENOG41067V3 Antibiotic biosynthesis monooxygenase G6N24_RS00600 ENOG4105DND Transcriptional regulator G6N24_RS00610 ENOG4105DG4 malate L-lactate dehydrogenase G6N24_RS00615 ENOG4105C0A alcohol dehydrogenase G6N24_RS00650 ENOG4105EZR dyp-type peroxidase family protein G6N24_RS00655 ENOG4105DFM M18 family aminopeptidase G6N24_RS00705 ENOG4105CXB phosphoribosylaminoimidazole synthetase G6N24_RS00715 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) G6N24_RS00730 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) G6N24_RS00755 ENOG4108X6U May play a role in the intracellular transport of hydrophobic ligands G6N24_RS00760 ENOG4105PKJ carbohydrate binding G6N24_RS00780 ENOG4107NHD transcriptional regulator G6N24_RS00800 ENOG4105E2Z phosphate ABC transporter (Permease G6N24_RS00805 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) G6N24_RS00840 ENOG41082SX arsR family transcriptional regulator G6N24_RS00845 ENOG4107Y2X deaminase G6N24_RS00905 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase G6N24_RS00925 ENOG41082BM Transcriptional regulator, arsr family G6N24_RS00945 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) G6N24_RS00965 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) G6N24_RS00980 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone G6N24_RS00985 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G6N24_RS00995 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) G6N24_RS01005 ENOG4105D2B acyl-CoA dehydrogenase G6N24_RS01010 ENOG4105CC9 acyl-Coa dehydrogenase G6N24_RS01020 ENOG4105CHU acetyl-coa acetyltransferase G6N24_RS01050 ENOG4108JYK Dehydrogenase G6N24_RS01055 ENOG4107QP6 Xylose isomerase domain protein TIM barrel G6N24_RS01065 ENOG4105EWI Short-chain dehydrogenase reductase Sdr G6N24_RS01070 ENOG4105QE3 oxidoreductase G6N24_RS01075 ENOG4107QNK )-transporter G6N24_RS01080 ENOG4105CPQ Dehydrogenase G6N24_RS01090 ENOG4108KK4 3-dehydroquinate synthase G6N24_RS01100 ENOG4108JYK Dehydrogenase G6N24_RS01155 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein G6N24_RS01175 ENOG4105MI0 Catalyzes the non-heme iron(II)-dependent oxidative cleavage of 2,3-dihydroxyphenylpropionic acid and 2,3- dihydroxicinnamic acid into 2-hydroxy-6-ketononadienedioate and 2- hydroxy-6-ketononatrienedioate, respectively (By similarity) G6N24_RS01180 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein G6N24_RS01190 ENOG4105CHR reductase G6N24_RS01215 ENOG4107R16 Multicopper oxidase G6N24_RS01225 ENOG410880H cysteine synthase G6N24_RS01240 ENOG4107QI1 Mate efflux family protein G6N24_RS01280 ENOG4105DC7 peptidase M24 G6N24_RS01290 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G6N24_RS01330 ENOG41076PI Short-chain dehydrogenase reductase Sdr G6N24_RS01345 ENOG4105D2B acyl-CoA dehydrogenase G6N24_RS01360 ENOG4105CPN adenine deaminase G6N24_RS01370 ENOG4105DVW rieske (2Fe-2S) G6N24_RS01390 ENOG4105CHU acetyl-coa acetyltransferase G6N24_RS01395 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) G6N24_RS01435 ENOG4106A3M Cytochrome p-450 G6N24_RS01465 ENOG4107QIZ NADH dehydrogenase G6N24_RS01510 ENOG4105CC9 acyl-Coa dehydrogenase G6N24_RS01535 ENOG4105CHR reductase G6N24_RS01550 ENOG4105CY3 ABC transporter, permease G6N24_RS01620 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) G6N24_RS01630 ENOG4105E39 Enoyl-CoA hydratase G6N24_RS01680 ENOG4105CHU acetyl-coa acetyltransferase G6N24_RS01685 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase G6N24_RS01700 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) G6N24_RS01720 ENOG4105CFI type iii restriction protein res subunit G6N24_RS01740 ENOG4105EPU Molybdenum cofactor synthesis domain protein G6N24_RS01770 ENOG4105VEQ Cold shock protein G6N24_RS01800 ENOG4108N0W Major Facilitator superfamily G6N24_RS01820 ENOG4105XMC MarR family Transcriptional regulator G6N24_RS01835 ENOG410839S Toxic component of a toxin-antitoxin (TA) module (By similarity) G6N24_RS01850 ENOG4107R8H Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) G6N24_RS01875 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) G6N24_RS01885 ENOG4105D5G Transposase G6N24_RS01935 ENOG4105E2K Glycosyl transferase (Group 1 G6N24_RS02005 ENOG4105CHU acetyl-coa acetyltransferase G6N24_RS02160 ENOG4107TB5 TRANSCRIPTIONal G6N24_RS02200 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) G6N24_RS02215 ENOG4107QKV phosphomannomutase G6N24_RS02225 ENOG4105EIP mannose-6-phosphate isomerase G6N24_RS02235 ENOG4105CUB amino acid G6N24_RS02240 ENOG4105EEF Alkane 1-monooxygenase G6N24_RS02245 ENOG41084UD rubredoxin G6N24_RS02250 ENOG4105VCQ rubredoxin G6N24_RS02295 ENOG4108S7Q sigma 54 modulation protein ribosomal protein S30ea G6N24_RS02300 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving G6N24_RS02310 ENOG4108SVW integral membrane protein G6N24_RS02330 ENOG4105CSR polyphosphate kinase 2 G6N24_RS02350 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) G6N24_RS02355 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase G6N24_RS02360 ENOG4108RAV Conserved protein G6N24_RS02365 ENOG4107EXU Short-chain dehydrogenase reductase Sdr G6N24_RS02380 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit G6N24_RS02415 ENOG4108ZM9 phosphoglycerate mutase G6N24_RS02430 ENOG4105C1J atp-dependent rna helicase G6N24_RS02475 ENOG4108YIQ Alpha beta hydrolase G6N24_RS02515 ENOG4105D7V transposase G6N24_RS02550 ENOG4105WBQ Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) G6N24_RS02575 ENOG41063PX domain protein G6N24_RS02640 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase G6N24_RS02645 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) G6N24_RS02705 ENOG4105CHR reductase G6N24_RS02735 ENOG4105F2Z 3-oxoadipate enol-lactonase G6N24_RS02775 ENOG4105C7R Atpase associated with various cellular activities aaa_3 G6N24_RS02815 ENOG4105DF2 NADH dehydrogenase subunit j G6N24_RS02885 ENOG4105KVH Transcriptional regulator G6N24_RS02915 ENOG4108YYC ycei family G6N24_RS02940 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family G6N24_RS02990 ENOG4105JZI cytochrome P450 G6N24_RS03100 ENOG4105CHU acetyl-coa acetyltransferase G6N24_RS03150 ENOG4105C7Z Conserved Protein G6N24_RS03190 ENOG4105CS9 pantothenic acid kinase G6N24_RS03195 ENOG4105EKQ RNA-directed DNA polymerase G6N24_RS03200 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) G6N24_RS03215 ENOG4107RSM transcriptional regulator G6N24_RS03285 ENOG4108IAB Phoh family G6N24_RS03290 ENOG4107T94 Endo-14-beta-xylanase G6N24_RS03355 ENOG4105YX8 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) G6N24_RS03360 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) G6N24_RS03390 ENOG4105C3G gtp-binding protein G6N24_RS03450 ENOG4108J5G 6-phosphogluconate dehydrogenase G6N24_RS03475 ENOG4105F04 LysR family Transcriptional regulator G6N24_RS03520 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) G6N24_RS03545 ENOG4105CFF transcriptional regulator G6N24_RS03550 ENOG4105DXD 2-methylcitrate dehydratase G6N24_RS03555 ENOG4105CR4 methylisocitrate lyase G6N24_RS03600 ENOG4106PGW Short-chain dehydrogenase reductase Sdr G6N24_RS03605 ENOG4105C26 Dehydrogenase G6N24_RS03610 ENOG4106A3M Cytochrome p-450 G6N24_RS03630 ENOG4105GRZ Ycii-related protein G6N24_RS03635 ENOG4105CHP RNA polymerase G6N24_RS03655 ENOG4105CHU acetyl-coa acetyltransferase G6N24_RS03660 ENOG4106YT9 Enoyl-CoA hydratase G6N24_RS03685 ENOG4105CGD Nad-dependent epimerase dehydratase G6N24_RS03695 ENOG4105CGU Enoyl-CoA hydratase G6N24_RS03700 ENOG410846T CoA-transferase family III G6N24_RS03710 ENOG4107R13 MMPL domain protein G6N24_RS03745 ENOG410905P Pyridoxamine 5-phosphate G6N24_RS03795 ENOG4108IUE nitrate reductase beta subunit G6N24_RS03855 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase G6N24_RS03860 ENOG4108Z4U Ferredoxin G6N24_RS03890 ENOG4108IUE nitrate reductase beta subunit G6N24_RS03905 ENOG4107QND Nitrite extrusion protein G6N24_RS03960 ENOG4108Z6Z Transcriptional regulator G6N24_RS04015 ENOG4105C26 Dehydrogenase G6N24_RS04020 ENOG41062BK proline dehydrogenase G6N24_RS04030 ENOG4108XG4 DNA-binding transcriptional regulator G6N24_RS04050 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) G6N24_RS04055 ENOG4105CEY Amp-dependent synthetase and ligase G6N24_RS04080 ENOG4105CSH Transporter G6N24_RS04105 ENOG4108URH decarboxylase G6N24_RS04120 ENOG4105C3Q Glycosyl transferase, family 2 G6N24_RS04130 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) G6N24_RS04155 ENOG4105DIM ABC transporter G6N24_RS04160 ENOG4105CIG ABC transporter G6N24_RS04165 ENOG4108X07 Tetr family transcriptional regulator G6N24_RS04190 ENOG4106684 G6N24_RS04195 ENOG4105C0H protease G6N24_RS04220 ENOG4105CJW magnesium transporter G6N24_RS04260 ENOG4105D7N magnesium and cobalt transport protein CorA G6N24_RS04360 ENOG4105CQB FAD linked oxidase domain protein G6N24_RS04415 ENOG4105IDI abc transporter atp-binding protein G6N24_RS04480 ENOG4105F5W AtP-binding protein G6N24_RS04490 ENOG4105D06 uba thif-type nad fad binding protein G6N24_RS04650 ENOG4105C57 major facilitator superfamily G6N24_RS04700 ENOG4105C75 arginyL-tRNA synthetase G6N24_RS04705 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) G6N24_RS04735 ENOG4105J5T Amp-dependent synthetase and ligase G6N24_RS04750 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) G6N24_RS04795 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) G6N24_RS04890 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) G6N24_RS04900 ENOG4108IUN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) G6N24_RS04910 ENOG4107RKP Nicotinate phosphoribosyltransferase G6N24_RS04950 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) G6N24_RS04960 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) G6N24_RS04970 ENOG4105WX6 Membrane G6N24_RS04980 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation G6N24_RS04995 ENOG4105C1G acyl-Coa dehydrogenase G6N24_RS05010 ENOG4105IYB L-carnitine dehydratase bile acid-inducible protein F G6N24_RS05015 ENOG4105C1G acyl-Coa dehydrogenase G6N24_RS05020 ENOG4108WYP Transcriptional regulator G6N24_RS05035 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) G6N24_RS05040 ENOG4108UKI Enoyl-CoA hydratase G6N24_RS05065 ENOG4105X7H acyl-CoA dehydrogenase G6N24_RS05070 ENOG4107QX3 carboxylase G6N24_RS05110 ENOG4105Q56 cytochrome P450 G6N24_RS05125 ENOG4105D2B acyl-CoA dehydrogenase G6N24_RS05130 ENOG4105D2B acyl-CoA dehydrogenase G6N24_RS05155 ENOG4105CEY Amp-dependent synthetase and ligase G6N24_RS05160 ENOG4105C1G acyl-Coa dehydrogenase G6N24_RS05165 ENOG4105CC9 acyl-Coa dehydrogenase G6N24_RS05170 ENOG4105CC9 acyl-Coa dehydrogenase G6N24_RS05175 ENOG4105C1G acyl-Coa dehydrogenase G6N24_RS05185 ENOG4105CHR reductase G6N24_RS05230 ENOG4108WKN secreted protein G6N24_RS05245 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) G6N24_RS05265 ENOG4107UBC ErfK ybiS ycfS ynhG family protein G6N24_RS05280 ENOG4105D7A ATP-binding protein G6N24_RS05285 ENOG4105E1F short-chain dehydrogenase reductase G6N24_RS05300 ENOG4105FBW Monooxygenase G6N24_RS05320 ENOG4107QX3 carboxylase G6N24_RS05330 ENOG4105C1G acyl-Coa dehydrogenase G6N24_RS05335 ENOG4105DJG MaoC domain protein dehydratase G6N24_RS05355 ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 G6N24_RS05405 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) G6N24_RS05495 ENOG4105E2K Glycosyl transferase (Group 1 G6N24_RS05515 ENOG4105C29 acyl-CoA thioesterase G6N24_RS05650 ENOG4105E4E Thioester reductase domain-containing protein G6N24_RS05700 ENOG4107DZG Ribbon-helix-helix protein, copG family G6N24_RS05710 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) G6N24_RS05835 ENOG4107ZED Uncharacterised protein family UPF0047 G6N24_RS05840 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) G6N24_RS05855 ENOG4105E2X shikimate dehydrogenase G6N24_RS05995 ENOG4105CXN decarboxylase G6N24_RS06025 ENOG4106H3A restriction G6N24_RS06125 ENOG4105SKN orotidine 5''-phosphate decarboxylase G6N24_RS06135 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) G6N24_RS06150 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP G6N24_RS06160 ENOG4105F95 Monooxygenase G6N24_RS06290 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) G6N24_RS06300 ENOG4105CHW UPF0052 protein G6N24_RS06325 ENOG4105EBR Carboxylesterase G6N24_RS06330 ENOG4105CEY Amp-dependent synthetase and ligase G6N24_RS06355 ENOG41069FZ L,D-transpeptidase catalytic domain G6N24_RS06370 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase G6N24_RS06375 ENOG4105BZA Phosphoglycerate kinase G6N24_RS06445 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein G6N24_RS06475 ENOG4107JC6 Membrane G6N24_RS06495 ENOG4105C3K feS assembly ATPase SufC G6N24_RS06505 ENOG4108UNV SUF system FeS assembly protein, NifU family G6N24_RS06510 ENOG4105VG1 fes assembly suf system protein G6N24_RS06515 ENOG4105C1G acyl-Coa dehydrogenase G6N24_RS06540 ENOG41080RH Thioredoxin G6N24_RS06550 ENOG4105C5H ABC transporter G6N24_RS06560 ENOG4108Q5F Tetr family transcriptional regulator G6N24_RS06565 ENOG4107QM5 aconitate hydratase G6N24_RS06575 ENOG4105ZXU NLP P60 protein G6N24_RS06585 ENOG4105C7R Atpase associated with various cellular activities aaa_3 G6N24_RS06595 ENOG4107QVM von Willebrand factor, type A G6N24_RS06645 ENOG4108RQS Two component transcriptional regulator (Winged helix family G6N24_RS06690 ENOG4105WKW Pfam:DUF1458 G6N24_RS06820 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) G6N24_RS06885 ENOG4108IG5 Transcriptional regulator G6N24_RS06915 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) G6N24_RS06925 ENOG4105HDK L-asparaginase G6N24_RS06960 ENOG4108W6C Dehydrogenase G6N24_RS07050 ENOG4105CSW GntR family transcriptional regulator G6N24_RS07075 ENOG4105ZXU NLP P60 protein G6N24_RS07145 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase G6N24_RS07150 ENOG4105EN6 Membrane G6N24_RS07175 ENOG4105CIH Imidazole acetol-phosphate transaminase G6N24_RS07190 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase G6N24_RS07195 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) G6N24_RS07275 ENOG4105C29 acyl-CoA thioesterase G6N24_RS07285 ENOG4105BZ1 (ABC) transporter G6N24_RS07290 ENOG4108JJ9 ABC, transporter G6N24_RS07295 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii G6N24_RS07300 ENOG4105C4M (Ubiquinol oxidase) subunit I G6N24_RS07410 ENOG4105C5X domain protein G6N24_RS07435 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) G6N24_RS07495 ENOG4108NNZ chitinase G6N24_RS07515 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) G6N24_RS07535 ENOG4107RCI amp-dependent synthetase and ligase G6N24_RS07545 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) G6N24_RS07595 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) G6N24_RS07650 ENOG4108JA1 polyketide synthase G6N24_RS07650 ENOG4108JA1 polyketide synthase G6N24_RS07665 ENOG4105C5H ABC transporter G6N24_RS07690 ENOG4105W49 UPF0434 protein G6N24_RS07705 ENOG4105CJ1 ABC, transporter G6N24_RS07740 ENOG4105DSU hydrolase G6N24_RS07805 ENOG4105C0D helicase G6N24_RS07820 ENOG4105DB3 bacteriochlorophyll chlorophyll a synthase G6N24_RS07865 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) G6N24_RS07880 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) G6N24_RS07890 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) G6N24_RS08020 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) G6N24_RS08060 ENOG4105PP6 Membrane G6N24_RS08080 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) G6N24_RS08085 ENOG4108JPZ Monovalent cation H antiporter subunit D G6N24_RS08095 ENOG4107TDF Formate hydrogenlyase subunit 4 G6N24_RS08105 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit G6N24_RS08115 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) G6N24_RS08125 ENOG4105C7W Xanthine dehydrogenase G6N24_RS08130 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding G6N24_RS08135 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit G6N24_RS08150 ENOG4105IDI abc transporter atp-binding protein G6N24_RS08200 ENOG4105C59 p-type ATPase G6N24_RS08210 ENOG4108W6C Dehydrogenase G6N24_RS08230 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) G6N24_RS08255 ENOG4108MJN Glycosyl Transferase G6N24_RS08280 ENOG41061H0 Monooxygenase G6N24_RS08290 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) G6N24_RS08300 ENOG4107RBB ABC transporter, permease G6N24_RS08305 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) G6N24_RS08375 ENOG4105XTG Pfam:DUF156 G6N24_RS08435 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) G6N24_RS08610 ENOG4105CX0 fumarate reductase succinate dehydrogenase flavoprotein domain protein G6N24_RS08680 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor G6N24_RS08705 ENOG4107UAX integral membrane protein G6N24_RS08710 ENOG4105C37 (CBS) domain G6N24_RS08720 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) G6N24_RS08770 ENOG4105CEP NADH dehydrogenase G6N24_RS08775 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone G6N24_RS08835 ENOG4105EMU Dehydrogenase G6N24_RS08850 ENOG4105CHU acetyl-coa acetyltransferase G6N24_RS08895 ENOG4108X7C Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) G6N24_RS08905 ENOG4105C5Q Transcriptional regulator G6N24_RS08960 ENOG4105C5F glutamine synthetase G6N24_RS08985 ENOG4108IXY short-chain dehydrogenase reductase G6N24_RS09100 ENOG4105F2Z 3-oxoadipate enol-lactonase G6N24_RS09105 ENOG4105CEV competence damage-inducible protein G6N24_RS09110 ENOG4107RGD Major Facilitator superfamily G6N24_RS09120 ENOG41082T9 Membrane G6N24_RS09200 ENOG4105E4J Cytochrome c oxidase caa3-type, assembly factor ctag-related protein G6N24_RS09220 ENOG4105D3R alkyl hydroperoxide reductase G6N24_RS09225 ENOG4107QI6 Cysteine desulfurase G6N24_RS09235 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) G6N24_RS09270 ENOG4105EXC Acyl-transferase G6N24_RS09285 ENOG4105CRW Short chain fatty acid transporter G6N24_RS09330 ENOG4105CEY Amp-dependent synthetase and ligase G6N24_RS09335 ENOG4105D2B acyl-CoA dehydrogenase G6N24_RS09340 ENOG4105CC9 acyl-Coa dehydrogenase G6N24_RS09355 ENOG4105F57 Anthranilate dioxygenase reductase G6N24_RS09370 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) G6N24_RS09480 ENOG4105D74 hydrolase G6N24_RS09495 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) G6N24_RS09520 ENOG4108J2P Alpha beta hydrolase fold G6N24_RS09525 ENOG4108WUH Transcriptional regulator, TetR family G6N24_RS09530 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein G6N24_RS09580 ENOG4108WKN secreted protein G6N24_RS09625 ENOG4107EMZ glycosyl transferase family G6N24_RS09655 ENOG4107PBH Toxic component of a toxin-antitoxin (TA) module. A G6N24_RS09795 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) G6N24_RS09825 ENOG4105DRS transport system, permease G6N24_RS09830 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component G6N24_RS09845 ENOG4108RWI nicotinamidase G6N24_RS09855 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family G6N24_RS09865 ENOG4105EBR Carboxylesterase G6N24_RS09875 ENOG4105FUY alpha subunit G6N24_RS09880 ENOG4105M63 4-hydroxybenzoate synthetase (chorismate lyase) G6N24_RS09905 ENOG4105CEY Amp-dependent synthetase and ligase G6N24_RS09910 ENOG4105CEY Amp-dependent synthetase and ligase G6N24_RS09950 ENOG4105CPN adenine deaminase G6N24_RS09975 ENOG4105CTK cobaltochelatase, cobn subunit G6N24_RS10000 ENOG4108J4B Beta-lactamase G6N24_RS10025 ENOG4108RG3 short-chain dehydrogenase reductase G6N24_RS10080 ENOG4105MPZ Pfam:DUF1023 G6N24_RS10165 ENOG4105RYD Toxic component of a toxin-antitoxin (TA) module. A G6N24_RS10305 ENOG4107SVN transposase G6N24_RS10310 ENOG4105D5G Transposase G6N24_RS10315 ENOG4105D5G Transposase G6N24_RS10330 ENOG4105C3R Methionine synthase G6N24_RS10345 ENOG4108BAS reductase G6N24_RS10405 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) G6N24_RS10425 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) G6N24_RS10475 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) G6N24_RS10515 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) G6N24_RS10520 ENOG4105KNI merR family transcriptional Regulator G6N24_RS10530 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) G6N24_RS10540 ENOG4105D5G Transposase G6N24_RS10555 ENOG4105CJN penicillin-binding protein G6N24_RS10580 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) G6N24_RS10585 ENOG4105R14 (LipO)protein G6N24_RS10600 ENOG41090CE integral membrane protein G6N24_RS10605 ENOG4105KYH transcriptional regulatory protein G6N24_RS10615 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase G6N24_RS10650 ENOG4105D0U Arsenite-activated ATPase (ArsA) G6N24_RS10665 ENOG4108IQE Amp-dependent synthetase and ligase G6N24_RS10745 ENOG4107T4Z adenosine kinase G6N24_RS10775 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) G6N24_RS10800 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) G6N24_RS11050 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) G6N24_RS11070 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) G6N24_RS11075 ENOG4105PDP Short chain dehydrogenase G6N24_RS11210 ENOG41067SE Tetr family transcriptional regulator G6N24_RS11285 ENOG4105CHR reductase G6N24_RS11295 ENOG4108J2R molybdopterin oxidoreductase G6N24_RS11380 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) G6N24_RS11465 ENOG4108JYK Dehydrogenase G6N24_RS11470 ENOG4105CPP Dehydrogenase, E1 component G6N24_RS11475 ENOG4105C7S Dehydrogenase G6N24_RS11480 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) G6N24_RS11505 ENOG4107SHJ sulfite reductase subunit b G6N24_RS11605 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component G6N24_RS11610 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component G6N24_RS11625 ENOG4105CUB amino acid G6N24_RS11630 ENOG4105CIK Amidinotransferase G6N24_RS11680 ENOG4107QND Nitrite extrusion protein G6N24_RS11690 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) G6N24_RS11705 ENOG4105C9B Cysteine desulfurase G6N24_RS11725 ENOG4105D7W serine acetyltransferase G6N24_RS11855 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) G6N24_RS11865 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) G6N24_RS11905 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) G6N24_RS11920 ENOG4108KPJ rna polymerase sigma factor G6N24_RS11955 ENOG4105C0W non-ribosomal peptide synthetase G6N24_RS11965 ENOG4105CEY Amp-dependent synthetase and ligase G6N24_RS11980 ENOG4107EEY synthase G6N24_RS11985 ENOG4107EEY synthase G6N24_RS12000 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase G6N24_RS12065 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 G6N24_RS12095 ENOG4108I5D sulfate abc transporter G6N24_RS12100 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein G6N24_RS12115 ENOG4105BZP glycoside hydrolase 15-related G6N24_RS12135 ENOG41080XP Cbs domain G6N24_RS12140 ENOG4107XDQ Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) G6N24_RS12180 ENOG4105KQC Competence protein G6N24_RS12190 ENOG4107Q3C acyl-Coa dehydrogenase G6N24_RS12225 ENOG4108TZC G6N24_RS12235 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) G6N24_RS12240 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) G6N24_RS12245 ENOG4106FRU abrb family transcriptional regulator G6N24_RS12265 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit G6N24_RS12270 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) G6N24_RS12275 ENOG4105D8X mechanosensitive ion channel G6N24_RS12285 ENOG4108RVA ribokinase G6N24_RS12315 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control G6N24_RS12330 ENOG4105C03 ribonuclease G6N24_RS12335 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) G6N24_RS12345 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase G6N24_RS12360 ENOG4105EG6 Saccharopine dehydrogenase G6N24_RS12375 ENOG41080AZ Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) G6N24_RS12380 ENOG4105DQU oxidoreductase, subunit beta G6N24_RS12385 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein G6N24_RS12390 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) G6N24_RS12395 ENOG4107QK5 Homocysteine s-methyltransferase G6N24_RS12400 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) G6N24_RS12440 ENOG4105MC2 DSBA oxidoreductase G6N24_RS12470 ENOG4108Z18 K06886 hemoglobin G6N24_RS12475 ENOG4105CG3 alpha amylase, catalytic region G6N24_RS12490 ENOG4105C7I Dehydrogenase G6N24_RS12500 ENOG4107YH6 single-stranded DNA-binding protein G6N24_RS12555 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase G6N24_RS12560 ENOG4105RM9 Protocatechuate 3,4-dioxygenase alpha G6N24_RS12580 ENOG4105FUY alpha subunit G6N24_RS12595 ENOG4108QJ2 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase G6N24_RS12600 ENOG4105FB2 class II Aldolase G6N24_RS12605 ENOG4107HP6 Transcriptional regulator G6N24_RS12735 ENOG4105E0X reductase G6N24_RS12795 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) G6N24_RS12800 ENOG4105C0X amino acid G6N24_RS12805 ENOG4107VEG TrkA-N domain protein G6N24_RS12835 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) G6N24_RS12960 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) G6N24_RS12980 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) G6N24_RS12985 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) G6N24_RS13010 ENOG4105C99 atpase involved in dna repair G6N24_RS13030 ENOG4107KFM Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) G6N24_RS13050 ENOG4105MXB limonene-12-epoxide hydrolase G6N24_RS13125 ENOG4105CVR type I restriction-modification system G6N24_RS13135 ENOG4105T0Z Conserved Protein G6N24_RS13155 ENOG4105D2B acyl-CoA dehydrogenase G6N24_RS13160 ENOG4105D2B acyl-CoA dehydrogenase G6N24_RS13165 ENOG4105CHR reductase G6N24_RS13200 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) G6N24_RS13230 ENOG4105DCF alanine dehydrogenase G6N24_RS13235 ENOG4107QWG 2-Nitropropane dioxygenase G6N24_RS13265 ENOG4105C1G acyl-Coa dehydrogenase G6N24_RS13335 ENOG4105PWE CRISPR-associated protein cas2 G6N24_RS13395 ENOG41060JE PilT protein domain protein G6N24_RS13435 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component G6N24_RS13445 ENOG4105SFS phosphoesterase RecJ domain protein G6N24_RS13505 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) G6N24_RS13515 ENOG4106D5S Corrinoid adenosyltransferase BtuR CobO CobP G6N24_RS13555 ENOG4105G5W regulator Fur family G6N24_RS13560 ENOG4105D9G High-affinity G6N24_RS13565 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) G6N24_RS13600 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) G6N24_RS13645 ENOG4108Z86 Glutamine amidotransferase G6N24_RS13660 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) G6N24_RS13740 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) G6N24_RS13750 ENOG4107NHD transcriptional regulator G6N24_RS13835 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) G6N24_RS13855 ENOG4107XUM An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) G6N24_RS13875 ENOG4105DZ1 carboxypeptidase G6N24_RS13940 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) G6N24_RS13985 ENOG41087HT growth G6N24_RS13990 ENOG4108VTW Thioesterase G6N24_RS14000 ENOG4107EEY synthase G6N24_RS14060 ENOG4107RCI amp-dependent synthetase and ligase G6N24_RS14100 ENOG4105M63 4-hydroxybenzoate synthetase (chorismate lyase) G6N24_RS14105 ENOG4107RCI amp-dependent synthetase and ligase G6N24_RS14165 ENOG4106H78 methyltransferase G6N24_RS14170 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) G6N24_RS14210 ENOG4105DP4 dak2 domain fusion protein ylov G6N24_RS14250 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase G6N24_RS14280 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) G6N24_RS14305 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) G6N24_RS14310 ENOG4105ERH Fumarylacetoacetate hydrolase G6N24_RS14315 ENOG4105E5T Major Facilitator Superfamily G6N24_RS14320 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) G6N24_RS14335 ENOG4105CS1 NAD(P)H quinone oxidoreductase G6N24_RS14390 ENOG4105CTQ phosphohexokinase G6N24_RS14395 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) G6N24_RS14420 ENOG4105NPE arsR family transcriptional regulator G6N24_RS14500 ENOG4105C10 Electron transfer flavoprotein G6N24_RS14540 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase G6N24_RS14565 ENOG4105VPX protein, conserved in bacteria G6N24_RS14575 ENOG4105EVB acetyltransferase G6N24_RS14580 ENOG4108V0V Pyrrolo-quinoline quinone G6N24_RS14595 ENOG4107QVI Methyltransferase, type 11 G6N24_RS14610 ENOG4105DKW ABC transporter G6N24_RS14615 ENOG4105EAC phosphoserine phosphatase G6N24_RS14660 ENOG4107RN6 Monooxygenase G6N24_RS14665 ENOG4105EJ2 Transcriptional regulator G6N24_RS14735 ENOG4107YCY Transcriptional regulator G6N24_RS14750 ENOG4105D2B acyl-CoA dehydrogenase G6N24_RS14765 ENOG4105D22 carbon starvation protein G6N24_RS14870 ENOG4105FBW Monooxygenase G6N24_RS14875 ENOG4105CKW Inner membrane protein yedI G6N24_RS14885 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein G6N24_RS14900 ENOG4108KC1 acyl-Coa dehydrogenase G6N24_RS14935 ENOG4107S1E Beta-lactamase G6N24_RS14940 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) G6N24_RS15000 ENOG4107RYD Part of the ABC transporter FtsEX involved in cellular division (By similarity) G6N24_RS15005 ENOG4105CAK Cell division ATP-binding protein ftsE G6N24_RS15015 ENOG4105D8X mechanosensitive ion channel G6N24_RS15020 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) G6N24_RS15030 ENOG4105CQB FAD linked oxidase domain protein G6N24_RS15085 ENOG4107TK4 histidinol-phosphate phosphatase G6N24_RS15100 ENOG4105C1G acyl-Coa dehydrogenase G6N24_RS15105 ENOG4108NNZ chitinase G6N24_RS15180 ENOG4105C0D helicase G6N24_RS15245 ENOG4105CK6 Two component transcriptional regulator (Winged helix family G6N24_RS15250 ENOG4105BZU Histidine kinase G6N24_RS15265 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) G6N24_RS15270 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) G6N24_RS15315 ENOG4105DXN mazG family G6N24_RS15360 ENOG4105K89 arsenate reductase G6N24_RS15380 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) G6N24_RS15390 ENOG4105CEY Amp-dependent synthetase and ligase G6N24_RS15395 ENOG4107RCI amp-dependent synthetase and ligase G6N24_RS15415 ENOG4105F8V Hydrolase, tatD family G6N24_RS15475 ENOG410870F Cyclic nucleotide-binding protein G6N24_RS15520 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase G6N24_RS15525 ENOG41080UU 5-formyltetrahydrofolate cyclo-ligase G6N24_RS15545 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) G6N24_RS15580 ENOG4107QX3 carboxylase G6N24_RS15595 ENOG4105E39 Enoyl-CoA hydratase G6N24_RS15655 ENOG4105C0P Mg chelatase subunit ChlI G6N24_RS15675 ENOG41078VV 34 kDa antigenic protein G6N24_RS15690 ENOG4105CMV Succinyl-CoA synthetase subunit beta G6N24_RS15720 ENOG4107QP8 phosphohexose isomerase G6N24_RS15795 ENOG410846T CoA-transferase family III G6N24_RS15805 ENOG4105CHH sulfate transporter G6N24_RS15830 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) G6N24_RS15835 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit G6N24_RS15850 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase G6N24_RS15855 ENOG4105D8K carboxyl transferase G6N24_RS15890 ENOG4108JIK carboxylase G6N24_RS15930 ENOG4105C26 Dehydrogenase G6N24_RS15940 ENOG4107QRT dEAD DEAH box helicase G6N24_RS16010 ENOG4107RM1 amidohydrolase G6N24_RS16025 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain G6N24_RS16035 ENOG4105FBN Acid phosphatase G6N24_RS16105 ENOG4105E33 succinate dehydrogenase G6N24_RS16120 ENOG4108KPJ rna polymerase sigma factor G6N24_RS16125 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) G6N24_RS16130 ENOG4105DZ1 carboxypeptidase G6N24_RS16155 ENOG4107QNK )-transporter G6N24_RS16160 ENOG4105CE4 GlcNAc 6-P deacetylase G6N24_RS16170 ENOG4107H3J ribonuclease G6N24_RS16195 ENOG4108IQK o-acetylhomoserine G6N24_RS16220 ENOG4105DNP FAD linked oxidase domain protein G6N24_RS16240 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase G6N24_RS16245 ENOG4105IDI abc transporter atp-binding protein G6N24_RS16250 ENOG4105IDI abc transporter atp-binding protein G6N24_RS16270 ENOG4105GWZ Roadblock lc7 family protein G6N24_RS16280 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) G6N24_RS16300 ENOG4105C0B DNA polymerase III (alpha subunit) G6N24_RS16330 ENOG4105YXB Toxic component of a toxin-antitoxin (TA) module. A G6N24_RS16340 ENOG4105GCF PGAM G6N24_RS16445 ENOG4108VT4 G6N24_RS16485 ENOG41080E2 ribosomal-protein-alanine acetyltransferase G6N24_RS16510 ENOG4105CVK Glutamate decarboxylase G6N24_RS16525 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) G6N24_RS16595 ENOG4105EC2 ftsk spoIIIe G6N24_RS16605 ENOG41090GG peptidase S8 and S53, subtilisin, kexin, sedolisin G6N24_RS16650 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) G6N24_RS16690 ENOG4105C26 Dehydrogenase G6N24_RS16695 ENOG4105C1G acyl-Coa dehydrogenase G6N24_RS16710 ENOG4105CIH Imidazole acetol-phosphate transaminase G6N24_RS16725 ENOG4105C7K acetolactate synthase G6N24_RS16755 ENOG4106N8J Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) G6N24_RS16765 ENOG4105CMG Carbohydrate kinase G6N24_RS16770 ENOG4105C5I Dehydrogenase G6N24_RS16780 ENOG4105W4W Transcriptional regulator G6N24_RS16785 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) G6N24_RS16795 ENOG4108IXY short-chain dehydrogenase reductase G6N24_RS16815 ENOG4108XW1 Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) G6N24_RS16825 ENOG4105FBW Monooxygenase G6N24_RS16910 ENOG4105E7D Protein of unknown function (DUF3375) G6N24_RS16920 ENOG4105E6M Sulphatase-modifying factor protein G6N24_RS16935 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) G6N24_RS16945 ENOG4105F5W AtP-binding protein G6N24_RS16960 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) G6N24_RS16970 ENOG41082SA 50s ribosomal protein l29 G6N24_RS16990 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) G6N24_RS16995 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity G6N24_RS17000 ENOG4105KZR One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) G6N24_RS17010 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) G6N24_RS17030 ENOG4105F5W AtP-binding protein G6N24_RS17050 ENOG4107R2E Inherit from NOG: halimadienyl-diphosphate synthase activity G6N24_RS17060 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) G6N24_RS17105 ENOG4105XDV G6N24_RS17185 ENOG4105CSU acyl-Coa dehydrogenase G6N24_RS17205 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) G6N24_RS17240 ENOG4105DKQ ROK family G6N24_RS17265 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) G6N24_RS17275 ENOG4108NUI synthase G6N24_RS17295 ENOG4105CHP RNA polymerase G6N24_RS17330 ENOG4108F01 MaoC domain protein G6N24_RS17335 ENOG410900P UPF0336 protein G6N24_RS17360 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) G6N24_RS17385 ENOG4105DSY exodeoxyribonuclease V, gamma G6N24_RS17400 ENOG41062IE glyoxalase bleomycin resistance protein dioxygenase G6N24_RS17460 ENOG4105CWX Alpha-1,2-mannosidase G6N24_RS17480 ENOG41090G8 Toxic component of a toxin-antitoxin (TA) module. A G6N24_RS17575 ENOG4105D0M Protease HtpX homolog G6N24_RS17640 ENOG4105CEY Amp-dependent synthetase and ligase G6N24_RS17655 ENOG4105PDP Short chain dehydrogenase G6N24_RS17665 ENOG4105CJ3 phosphate transporter G6N24_RS17710 ENOG4105CMR udp-glucose 4-epimerase G6N24_RS17715 ENOG4107USC Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity) G6N24_RS17745 ENOG4105CRE cytochrome C G6N24_RS17755 ENOG4107QIV Cytochrome c biogenesis protein G6N24_RS17765 ENOG4108RH7 phosphoglycerate mutase G6N24_RS17780 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E G6N24_RS17785 ENOG4106ZX3 phosphonate ABC transporter, periplasmic phosphonate-binding protein G6N24_RS17790 ENOG4105FDT acyl-CoA dehydrogenase G6N24_RS17800 ENOG4105C85 amino acid G6N24_RS17860 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) G6N24_RS17865 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) G6N24_RS17880 ENOG4108RXW HAD-superfamily subfamily IB hydrolase G6N24_RS17890 ENOG4107UJ9 cyclopropane-fatty-acyl-phospholipid synthase G6N24_RS17925 ENOG41063NU Membrane G6N24_RS18010 ENOG4107R4N Cell wall formation (By similarity) G6N24_RS18040 ENOG4105TT9 Protein of unknown function (DUF2516) G6N24_RS18045 ENOG4105V9F hemagglutinin G6N24_RS18055 ENOG4106BRA Membrane G6N24_RS18140 ENOG4108D7R p-hydroxycinnamoyl CoA hydratase lyase G6N24_RS18210 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase G6N24_RS18315 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) G6N24_RS18390 ENOG4105IIU Aminopeptidase G6N24_RS18395 ENOG4105IIU Aminopeptidase G6N24_RS18450 ENOG4105CT1 (ABC) transporter G6N24_RS18495 ENOG4105DEN Luciferase family G6N24_RS18515 ENOG4105C1G acyl-Coa dehydrogenase G6N24_RS18520 ENOG4107R6D beta-lactam binding protein AmpH G6N24_RS18535 ENOG4105CEP NADH dehydrogenase G6N24_RS18565 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis G6N24_RS18575 ENOG4107XZ0 Peptidase M50 G6N24_RS18625 ENOG410838B Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) G6N24_RS18660 ENOG41084UG Pfam:DUF1458 G6N24_RS18740 ENOG4105KNI merR family transcriptional Regulator G6N24_RS18840 ENOG4105DF6 Fe-S oxidoreductase G6N24_RS18905 ENOG4105C6Y Udp-glucose 6-dehydrogenase G6N24_RS18940 ENOG4107P7U Inherit from COG: Protein of unknown function (DUF433) G6N24_RS18975 ENOG410834F Transcriptional regulator G6N24_RS18985 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein G6N24_RS18995 ENOG4105F8J Adenylate Guanylate cyclase G6N24_RS19025 ENOG4105HMD G6N24_RS19035 ENOG4105YVM Phosphoesterase, PA-phosphatase related G6N24_RS19045 ENOG4105E7Q Cob(II)yrinic acid a,c-diamide reductase G6N24_RS19070 ENOG41090GG peptidase S8 and S53, subtilisin, kexin, sedolisin G6N24_RS19125 ENOG4105IIV Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) G6N24_RS19175 ENOG4105D2B acyl-CoA dehydrogenase G6N24_RS19185 ENOG4105CEY Amp-dependent synthetase and ligase G6N24_RS19245 ENOG4107R7A Allophanate hydrolase subunit 2 G6N24_RS19280 ENOG4107QZF nitrite reductase NADPH large subunit G6N24_RS19300 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) G6N24_RS19320 ENOG4105CSU acyl-Coa dehydrogenase G6N24_RS19330 ENOG4105CHU acetyl-coa acetyltransferase G6N24_RS19335 ENOG4105CHR reductase G6N24_RS19365 ENOG41073B4 coagulation factor 5 8 type domain-containing protein G6N24_RS19400 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) G6N24_RS19445 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) G6N24_RS19450 ENOG4108M6P methyltransferase G6N24_RS19480 ENOG4105CEY Amp-dependent synthetase and ligase G6N24_RS19540 ENOG4105C1G acyl-Coa dehydrogenase G6N24_RS19550 ENOG4105E39 Enoyl-CoA hydratase G6N24_RS19560 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) G6N24_RS19570 ENOG4108Z4X TRANSCRIPTIONal G6N24_RS19595 ENOG410684T prevent-host-death family G6N24_RS19605 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) G6N24_RS19630 ENOG4108I9W Membrane G6N24_RS19670 ENOG4105C9K Endothelin-converting enzyme 1 G6N24_RS19675 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) G6N24_RS19685 ENOG4105WH1 Two component transcriptional regulator luxr family G6N24_RS19700 ENOG4105S7A ErfK ybiS ycfS ynhG family protein G6N24_RS19705 ENOG4105S7A ErfK ybiS ycfS ynhG family protein G6N24_RS19715 ENOG4105VPX protein, conserved in bacteria G6N24_RS19750 ENOG4105E5G Alpha beta hydrolase fold G6N24_RS19830 ENOG4105CY3 ABC transporter, permease G6N24_RS19890 ENOG4105CQB FAD linked oxidase domain protein G6N24_RS19915 ENOG4108R86 Transcriptional regulator G6N24_RS19925 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) G6N24_RS19930 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) G6N24_RS19940 ENOG4105C1G acyl-Coa dehydrogenase G6N24_RS19965 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr G6N24_RS19970 ENOG4105C26 Dehydrogenase G6N24_RS19975 ENOG4108UGJ Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) G6N24_RS19980 ENOG4105PF9 Transcriptional regulator G6N24_RS19985 ENOG4105CMQ Chloride channel G6N24_RS20020 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) G6N24_RS20070 ENOG4105EJ2 Transcriptional regulator G6N24_RS20115 ENOG41070F3 Catalyzes the ATP-dependent phosphorylation of maltose to maltose 1-phosphate. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, GlgE and GlgB (By similarity) G6N24_RS20170 ENOG4105CEY Amp-dependent synthetase and ligase G6N24_RS20175 ENOG4105CFN oxalyl-CoA decarboxylase G6N24_RS20180 ENOG4105DUM transcriptional regulator, lysR family G6N24_RS20185 ENOG4105FF0 ErfK YbiS YcfS YnhG G6N24_RS20210 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) G6N24_RS20215 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) G6N24_RS20220 ENOG4106YVY Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) (By similarity) G6N24_RS20250 ENOG4105EXC Acyl-transferase G6N24_RS20255 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G6N24_RS20265 ENOG4105CEY Amp-dependent synthetase and ligase G6N24_RS20370 ENOG4105CEY Amp-dependent synthetase and ligase G6N24_RS20450 ENOG4107XI7 Tetr family transcriptional regulator G6N24_RS20460 ENOG4107RSM transcriptional regulator G6N24_RS20475 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G6N24_RS20480 ENOG4105C1G acyl-Coa dehydrogenase G6N24_RS20520 ENOG4105FUY alpha subunit G6N24_RS20550 ENOG4105E9K Isocitrate dehydrogenase G6N24_RS20555 ENOG4105DYW oxidoreductase G6N24_RS20580 ENOG4105C1G acyl-Coa dehydrogenase G6N24_RS20615 ENOG4105DNP FAD linked oxidase domain protein G6N24_RS20665 ENOG4106IJN integrase catalytic domain-containing protein G6N24_RS20670 ENOG4105F5W AtP-binding protein G6N24_RS20700 ENOG410829C Binds together with S18 to 16S ribosomal RNA (By similarity) G6N24_RS20715 ENOG4105BZ4 penicillin-binding protein G6N24_RS20740 ENOG4105EV9 Alpha Beta Hydrolase G6N24_RS20765 ENOG4105C8T Leucyl-tRNA synthetase G6N24_RS20840 ENOG4105EUB pirin domain protein G6N24_RS20855 ENOG4105TV9 FHA Domain-Containing protein G6N24_RS20880 ENOG4107TPY serine threonine protein kinase G6N24_RS20935 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) G6N24_RS20950 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) G6N24_RS20955 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) G6N24_RS20960 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) G6N24_RS20980 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins G6N24_RS20995 ENOG4107QJE Chromosome Partitioning Protein G6N24_RS21010 ENOG4108E1C hydrolase G6N24_RS21050 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate G6N24_RS21155 ENOG4105F5W AtP-binding protein G6N24_RS21430 ENOG4106BSN growth G6N24_RS21465 ENOG4105CBC glutamate synthase G6N24_RS21480 ENOG4105DCG PHP domain protein G6N24_RS21560 ENOG4108KGH TRANSCRIPTIONal G6N24_RS21595 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) G6N24_RS21630 ENOG4105E9Q Acyl-transferase G6N24_RS21655 ENOG4106032 Glutathionylspermidine synthase G6N24_RS21660 ENOG4105P3N Membrane G6N24_RS21685 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) G6N24_RS21715 ENOG410602S Transferase G6N24_RS21730 ENOG4107ISF Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component the mycobacterial cell wall. Catalyzes the transfer of arabinofuranosyl (Araf) residues residue from the sugar donor beta-D-arabinofuranosyl-1-monophosphoryldecaprenol (DPA) to the arabinan domain to form terminal beta-(1- 2)-linked Araf residues, which marks the end point for AG arabinan biosynthesis before decoration with mycolic acids G6N24_RS21755 ENOG4107RCI amp-dependent synthetase and ligase G6N24_RS21765 ENOG4105D8K carboxyl transferase G6N24_RS21770 ENOG4105C1G acyl-Coa dehydrogenase G6N24_RS21800 ENOG4105C85 amino acid G6N24_RS21945 ENOG4107R72 Ceramidase G6N24_RS21990 ENOG4105CK6 Two component transcriptional regulator (Winged helix family G6N24_RS21995 ENOG4105BZU Histidine kinase G6N24_RS22005 ENOG4105EUZ Beta-lactamase domain protein G6N24_RS22025 ENOG4105CHR reductase G6N24_RS22035 ENOG4108RH7 phosphoglycerate mutase G6N24_RS22045 ENOG41060H3 Protein of unknown function (DUF1049) G6N24_RS22055 ENOG4108IJ8 ABC transporter G6N24_RS22060 ENOG4105E90 ABC transporter G6N24_RS22065 ENOG4105E90 ABC transporter G6N24_RS22075 ENOG4105EVN Prephenate dehydrogenase G6N24_RS22090 ENOG4108Z6B deaminase G6N24_RS22105 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) G6N24_RS22110 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) G6N24_RS22115 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) G6N24_RS22145 ENOG41082VC UPF0145 protein G6N24_RS22170 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) G6N24_RS22175 ENOG4105CT3 Monooxygenase G6N24_RS22290 ENOG41080ET plasmid maintenance system killer protein G6N24_RS22295 ENOG4105VDM plasmid maintenance system antidote protein, xre family G6N24_RS22300 ENOG4105C57 major facilitator superfamily G6N24_RS22305 ENOG4105CVN desaturase G6N24_RS22310 ENOG4105CPQ Dehydrogenase G6N24_RS22315 ENOG4107EEY synthase G6N24_RS22415 ENOG4105XT2 Transcriptional regulator G6N24_RS22425 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase G6N24_RS22440 ENOG4108RU2 n-acetylmuramoyl-l-alanine amidase G6N24_RS22465 ENOG4105DMS mur ligase G6N24_RS22470 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) G6N24_RS22495 ENOG4108NJC G6N24_RS22515 ENOG4105E46 N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process G6N24_RS22530 ENOG4105C92 Aminotransferase class V G6N24_RS22560 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) G6N24_RS22565 ENOG4105NTW Transcriptional regulator G6N24_RS22585 ENOG4105C7R Atpase associated with various cellular activities aaa_3 G6N24_RS22590 ENOG4108WQ6 secreted protein G6N24_RS22625 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase G6N24_RS22630 ENOG4105FUA antagonist G6N24_RS22635 ENOG4107MMM Anti-sigma-factor antagonist G6N24_RS22660 ENOG4107RSM transcriptional regulator G6N24_RS22680 ENOG4107RSM transcriptional regulator G6N24_RS22685 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) G6N24_RS22715 ENOG4107YCR Transcriptional regulator, ARSR family G6N24_RS22765 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) G6N24_RS22790 ENOG4105P8F nudix hydrolase G6N24_RS22845 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component G6N24_RS22850 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component G6N24_RS22855 ENOG4108JQ6 ABC transporter G6N24_RS22925 ENOG4108I5C dEAD DEAH box helicase G6N24_RS22950 ENOG4105C6E dna polymerase iii G6N24_RS23055 ENOG4105CPQ Dehydrogenase G6N24_RS23065 ENOG4105D74 hydrolase G6N24_RS23070 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) G6N24_RS23075 ENOG4105EUJ GTP cyclohydrolase i G6N24_RS23110 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) G6N24_RS23215 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) G6N24_RS23220 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) G6N24_RS23225 ENOG4105C8N cysteinyl-tRNA synthetase G6N24_RS23230 ENOG4105C2N RNA methyltransferase TrmH family group 3 G6N24_RS23260 ENOG4108SGK Tetr family transcriptional regulator G6N24_RS23265 ENOG4105D2B acyl-CoA dehydrogenase G6N24_RS23370 ENOG4105D2B acyl-CoA dehydrogenase G6N24_RS23375 ENOG4105D2B acyl-CoA dehydrogenase G6N24_RS23380 ENOG4105CC9 acyl-Coa dehydrogenase G6N24_RS23385 ENOG4105CEY Amp-dependent synthetase and ligase G6N24_RS23390 ENOG4105CC9 acyl-Coa dehydrogenase G6N24_RS23405 ENOG41086VY Fic/DOC family G6N24_RS23425 ENOG4105F2C Acetyl-CoA acetyltransferase G6N24_RS23435 ENOG4105EA8 2-Nitropropane dioxygenase G6N24_RS23450 ENOG4105E39 Enoyl-CoA hydratase G6N24_RS23460 ENOG4105CHR reductase G6N24_RS23475 ENOG4105F2C Acetyl-CoA acetyltransferase G6N24_RS23485 ENOG4108RK3 acyl-Coa dehydrogenase G6N24_RS23490 ENOG4105X7H acyl-CoA dehydrogenase G6N24_RS23495 ENOG410900P UPF0336 protein G6N24_RS23525 ENOG4105F5W AtP-binding protein G6N24_RS23535 ENOG4105RYD Toxic component of a toxin-antitoxin (TA) module. A G6N24_RS23550 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein G6N24_RS23555 ENOG4105IKQ hydratase G6N24_RS23570 ENOG4105DF3 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity) G6N24_RS23600 ENOG4105CIJ rieske 2fe-2S domain-containing protein G6N24_RS23605 ENOG4108Z0R Transferase