locus-tag	class	description
JK2ML_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
JK2ML_RS00010	COG0592	DNA-directed DNA polymerase activity
JK2ML_RS00025	COG0187	DNA topoisomerase II activity
JK2ML_RS00030	COG1372	Participates in initiation and elongation during chromosome replication
JK2ML_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
JK2ML_RS00035	COG3266	domain, Protein
JK2ML_RS00060	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
JK2ML_RS00085	COG0515	serine threonine protein kinase
JK2ML_RS00085	COG2815	serine threonine protein kinase
JK2ML_RS00090	COG0515	serine threonine protein kinase
JK2ML_RS00100	COG0772	Belongs to the SEDS family
JK2ML_RS00115	COG1716	ATPase activity
JK2ML_RS00150	COG1678	Uncharacterized ACR, COG1678
JK2ML_RS00205	COG1404	Belongs to the peptidase S8 family
JK2ML_RS00240	COG4842	Belongs to the WXG100 family
JK2ML_RS00245	COG4842	Belongs to the WXG100 family
JK2ML_RS00270	COG0464	growth
JK2ML_RS00315	COG0067	glutamate synthase
JK2ML_RS00315	COG0069	glutamate synthase activity
JK2ML_RS00315	COG0070	glutamate synthase
JK2ML_RS00380	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
JK2ML_RS00475	COG0561	phosphatase activity
JK2ML_RS00495	COG1216	Glycosyl transferase, family 2
JK2ML_RS00510	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
JK2ML_RS00515	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
JK2ML_RS00520	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
JK2ML_RS00525	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
JK2ML_RS00535	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
JK2ML_RS00535	COG3321	synthase
JK2ML_RS00535	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
JK2ML_RS00540	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
JK2ML_RS00555	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
JK2ML_RS00560	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
JK2ML_RS00570	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
JK2ML_RS00590	COG2246	polysaccharide biosynthetic process
JK2ML_RS00625	COG0604	alcohol dehydrogenase
JK2ML_RS00625	COG1028	Short-chain dehydrogenase reductase Sdr
JK2ML_RS00625	COG3321	synthase
JK2ML_RS00635	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
JK2ML_RS00685	COG3510	cephalosporin hydroxylase
JK2ML_RS00695	COG3268	Saccharopine dehydrogenase
JK2ML_RS00700	COG2226	methyltransferase
JK2ML_RS00705	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JK2ML_RS00710	COG0318	PFAM AMP-dependent synthetase and ligase
JK2ML_RS00715	COG3161	chorismate lyase activity
JK2ML_RS00790	COG0657	acetylesterase activity
JK2ML_RS00825	COG0210	DNA helicase
JK2ML_RS00830	COG0739	heme binding
JK2ML_RS00955	COG0745	RESPONSE REGULATOR receiver
JK2ML_RS00960	COG3850	Histidine kinase
JK2ML_RS00960	COG0642	Histidine kinase
JK2ML_RS00965	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
JK2ML_RS00970	COG0521	Mo-molybdopterin cofactor biosynthetic process
JK2ML_RS00970	COG0315	cyclic pyranopterin monophosphate synthase activity
JK2ML_RS00990	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
JK2ML_RS00995	COG1210	Utp--glucose-1-phosphate uridylyltransferase
JK2ML_RS01025	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
JK2ML_RS01025	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
JK2ML_RS01090	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
JK2ML_RS01090	COG1754	DNA topoisomerase type I activity
JK2ML_RS01100	COG0470	DNA polymerase III
JK2ML_RS01155	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
JK2ML_RS01160	COG2027	D-alanyl-D-alanine carboxypeptidase
JK2ML_RS01170	COG0037	tRNA processing
JK2ML_RS01175	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
JK2ML_RS01225	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
JK2ML_RS01235	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
JK2ML_RS01240	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
JK2ML_RS01245	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
JK2ML_RS01265	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
JK2ML_RS01280	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
JK2ML_RS01290	COG0542	response to heat
JK2ML_RS01305	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JK2ML_RS01310	COG0084	hydrolase, TatD family'
JK2ML_RS01330	COG0318	PFAM AMP-dependent synthetase and ligase
JK2ML_RS01340	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
JK2ML_RS01355	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
JK2ML_RS01395	COG0148	phosphopyruvate hydratase activity
JK2ML_RS01515	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JK2ML_RS01535	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
JK2ML_RS01570	COG1230	cation diffusion facilitator family transporter
JK2ML_RS01585	COG0191	fructose-bisphosphate aldolase activity
JK2ML_RS01590	COG0586	Pfam SNARE associated Golgi protein
JK2ML_RS01630	COG0351	phosphomethylpyrimidine kinase
JK2ML_RS01665	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JK2ML_RS01670	COG0515	serine threonine protein kinase
JK2ML_RS01705	COG1183	phosphatidylcholine synthase activity
JK2ML_RS01745	COG0657	acetylesterase activity
JK2ML_RS01760	COG4221	oxidoreductase activity
JK2ML_RS01770	COG0459	protein refolding
JK2ML_RS01790	COG2847	Copper chaperone PCu(A)C
JK2ML_RS01880	COG1121	(ABC) transporter
JK2ML_RS01935	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JK2ML_RS01965	COG0028	Belongs to the TPP enzyme family
JK2ML_RS02005	COG4842	Belongs to the WXG100 family
JK2ML_RS02050	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
JK2ML_RS02055	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
JK2ML_RS02055	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
JK2ML_RS02065	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
JK2ML_RS02075	COG0802	atpase or kinase
JK2ML_RS02080	COG0456	acetyltransferase
JK2ML_RS02080	COG1214	PFAM Peptidase M22, glycoprotease
JK2ML_RS02085	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
JK2ML_RS02095	COG0459	protein refolding
JK2ML_RS02140	COG0516	GMP reductase activity
JK2ML_RS02140	COG0517	IMP dehydrogenase activity
JK2ML_RS02145	COG0516	GMP reductase activity
JK2ML_RS02165	COG1554	hydrolase, family 65, central catalytic
JK2ML_RS02170	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JK2ML_RS02185	COG1260	myo-inositol-1-phosphate synthase
JK2ML_RS02190	COG1172	Belongs to the binding-protein-dependent transport system permease family
JK2ML_RS02200	COG1879	ABC-type sugar transport system periplasmic component
JK2ML_RS02250	COG3328	transposase activity
JK2ML_RS02275	COG5651	PPE family
JK2ML_RS02285	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JK2ML_RS02285	COG1877	trehalose-phosphatase activity
JK2ML_RS02310	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
JK2ML_RS02375	COG1376	ErfK ybiS ycfS ynhG family protein
JK2ML_RS02385	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
JK2ML_RS02395	COG0300	oxidoreductase activity
JK2ML_RS02470	COG0508	dehydrogenase complex catalyzes the overall conversion of
JK2ML_RS02520	COG0438	transferase activity, transferring glycosyl groups
JK2ML_RS02545	COG0667	Aldo Keto reductase
JK2ML_RS02580	COG0586	Pfam SNARE associated Golgi protein
JK2ML_RS02630	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
JK2ML_RS02670	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
JK2ML_RS02690	COG1022	Amp-dependent synthetase and ligase
JK2ML_RS02690	COG3320	Male sterility
JK2ML_RS02695	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
JK2ML_RS02700	COG1862	Preprotein translocase
JK2ML_RS02705	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
JK2ML_RS02710	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
JK2ML_RS02715	COG0747	negative chemotaxis
JK2ML_RS02725	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
JK2ML_RS02730	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
JK2ML_RS02735	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JK2ML_RS02740	COG0124	histidyl-tRNA synthetase
JK2ML_RS02745	COG0657	acetylesterase activity
JK2ML_RS02865	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
JK2ML_RS02890	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
JK2ML_RS02895	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
JK2ML_RS02975	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
JK2ML_RS02985	COG0505	Belongs to the CarA family
JK2ML_RS02990	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
JK2ML_RS03020	COG0194	GDP metabolic process
JK2ML_RS03060	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
JK2ML_RS03090	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
JK2ML_RS03100	COG0477	Major facilitator Superfamily
JK2ML_RS03140	COG0391	Required for morphogenesis under gluconeogenic growth conditions
JK2ML_RS03195	COG1376	ErfK ybiS ycfS ynhG family protein
JK2ML_RS03200	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
JK2ML_RS03210	COG0149	triose-phosphate isomerase activity
JK2ML_RS03235	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
JK2ML_RS03240	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
JK2ML_RS03245	COG0363	glucosamine-6-phosphate deaminase activity
JK2ML_RS03265	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
JK2ML_RS03270	COG0109	protoheme IX farnesyltransferase activity
JK2ML_RS03300	COG1131	(ABC) transporter
JK2ML_RS03320	COG1372	Participates in initiation and elongation during chromosome replication
JK2ML_RS03320	COG0719	Fe-S assembly protein
JK2ML_RS03325	COG0719	Fe-S assembly protein
JK2ML_RS03330	COG0396	ATPase activity
JK2ML_RS03335	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
JK2ML_RS03340	COG0822	iron-sulfur transferase activity
JK2ML_RS03345	COG2151	metal-sulfur cluster biosynthetic enzyme
JK2ML_RS03390	COG2308	Evidence 4 Homologs of previously reported genes of
JK2ML_RS03400	COG1305	Transglutaminase-like
JK2ML_RS03450	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
JK2ML_RS03495	COG0484	heat shock protein binding
JK2ML_RS03505	COG1702	phosphate starvation-inducible protein PhoH
JK2ML_RS03530	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
JK2ML_RS03545	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
JK2ML_RS03555	COG0210	DNA helicase
JK2ML_RS03570	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
JK2ML_RS03585	COG3480	Lon protease (S16) C-terminal proteolytic domain
JK2ML_RS03680	COG1960	acyl-CoA dehydrogenase activity
JK2ML_RS03690	COG0483	inositol monophosphate 1-phosphatase activity
JK2ML_RS03710	COG0493	'glutamate synthase
JK2ML_RS03725	COG2884	Cell division ATP-binding protein ftsE
JK2ML_RS03730	COG2177	Part of the ABC transporter FtsEX involved in
JK2ML_RS03810	COG0180	Tryptophanyl-tRNA synthetase
JK2ML_RS03840	COG1686	Belongs to the peptidase S11 family
JK2ML_RS03880	COG1053	succinate dehydrogenase
JK2ML_RS03890	COG2009	succinate dehydrogenase
JK2ML_RS03925	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
JK2ML_RS03930	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
JK2ML_RS03960	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
JK2ML_RS03980	COG1309	transcriptional regulator
JK2ML_RS04030	COG4770	biotin carboxylase activity
JK2ML_RS04040	COG2897	thiosulfate sulfurtransferase activity
JK2ML_RS04055	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
JK2ML_RS04060	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
JK2ML_RS04060	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
JK2ML_RS04075	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
JK2ML_RS04080	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
JK2ML_RS04085	COG1960	acyl-CoA dehydrogenase activity
JK2ML_RS04125	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
JK2ML_RS04130	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
JK2ML_RS04140	COG2217	Heavy metal translocating P-type atpase
JK2ML_RS04155	COG1316	TRANSCRIPTIONal
JK2ML_RS04195	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
JK2ML_RS04195	COG0778	Nitroreductase
JK2ML_RS04200	COG0391	Required for morphogenesis under gluconeogenic growth conditions
JK2ML_RS04225	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
JK2ML_RS04235	COG1482	cell wall glycoprotein biosynthetic process
JK2ML_RS04275	COG0745	RESPONSE REGULATOR receiver
JK2ML_RS04280	COG5000	phosphorelay sensor kinase activity
JK2ML_RS04280	COG5002	protein histidine kinase activity
JK2ML_RS04285	COG5401	PFAM Sporulation and spore germination
JK2ML_RS04300	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
JK2ML_RS04305	COG0653	protein targeting
JK2ML_RS04360	COG1162	GTPase activity
JK2ML_RS04365	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
JK2ML_RS04370	COG2135	peptidase activity
JK2ML_RS04440	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
JK2ML_RS04485	COG0513	Belongs to the DEAD box helicase family
JK2ML_RS04585	COG0232	Belongs to the dGTPase family. Type 2 subfamily
JK2ML_RS04595	COG0358	DNA primase activity
JK2ML_RS04630	COG1045	serine acetyltransferase
JK2ML_RS04635	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
JK2ML_RS04645	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
JK2ML_RS04650	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
JK2ML_RS04660	COG2223	nitrite transmembrane transporter activity
JK2ML_RS04715	COG0612	Peptidase, M16
JK2ML_RS04745	COG1090	epimerase
JK2ML_RS04765	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
JK2ML_RS04775	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
JK2ML_RS04810	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JK2ML_RS04820	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
JK2ML_RS04840	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
JK2ML_RS04850	COG2010	Cytochrome c
JK2ML_RS04855	COG1845	cytochrome c oxidase, subunit III
JK2ML_RS04885	COG1022	Amp-dependent synthetase and ligase
JK2ML_RS04900	COG0003	Pfam Anion-transporting ATPase
JK2ML_RS04930	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
JK2ML_RS04990	COG0768	penicillin binding
JK2ML_RS04995	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
JK2ML_RS05000	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
JK2ML_RS05005	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
JK2ML_RS05040	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
JK2ML_RS05045	COG1496	oxidoreductase activity
JK2ML_RS05050	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
JK2ML_RS05065	COG3599	regulation of cell shape
JK2ML_RS05205	COG1309	transcriptional regulator
JK2ML_RS05240	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
JK2ML_RS05240	COG0574	Belongs to the PEP-utilizing enzyme family
JK2ML_RS05275	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
JK2ML_RS05360	COG1674	ftsk spoiiie
JK2ML_RS05365	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
JK2ML_RS05395	COG4308	Limonene-1,2-epoxide hydrolase catalytic domain
JK2ML_RS05410	COG1372	Participates in initiation and elongation during chromosome replication
JK2ML_RS05410	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
JK2ML_RS05420	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
JK2ML_RS05460	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
JK2ML_RS05490	COG1388	LysM domain
JK2ML_RS05500	COG4044	May play a role in the intracellular transport of hydrophobic ligands
JK2ML_RS05530	COG1321	iron dependent repressor
JK2ML_RS05575	COG1940	carbohydrate kinase activity
JK2ML_RS05580	COG0483	inositol monophosphate 1-phosphatase activity
JK2ML_RS05640	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
JK2ML_RS05675	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
JK2ML_RS05710	COG0318	PFAM AMP-dependent synthetase and ligase
JK2ML_RS05730	COG4842	Belongs to the WXG100 family
JK2ML_RS05765	COG1611	Belongs to the LOG family
JK2ML_RS05775	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
JK2ML_RS05780	COG0463	Glycosyl transferase, family 2
JK2ML_RS05790	COG0519	Catalyzes the synthesis of GMP from XMP
JK2ML_RS05845	COG5662	AntiSigma factor
JK2ML_RS05850	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
JK2ML_RS05855	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
JK2ML_RS05860	COG2151	metal-sulfur cluster biosynthetic enzyme
JK2ML_RS05860	COG0489	protein tyrosine kinase activity
JK2ML_RS05915	COG0598	Magnesium transport protein CorA
JK2ML_RS05920	COG0039	L-malate dehydrogenase activity
JK2ML_RS05950	COG0508	dehydrogenase complex catalyzes the overall conversion of
JK2ML_RS05950	COG0567	Dehydrogenase, E1 component
JK2ML_RS06015	COG0277	FAD linked oxidase domain protein
JK2ML_RS06025	COG1573	uracil-dna glycosylase
JK2ML_RS06090	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
JK2ML_RS06100	COG2062	phosphohistidine phosphatase, SixA
JK2ML_RS06195	COG0019	diaminopimelate decarboxylase activity
JK2ML_RS06200	COG0460	homoserine dehydrogenase
JK2ML_RS06205	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
JK2ML_RS06220	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
JK2ML_RS06235	COG2890	protein-(glutamine-N5) methyltransferase activity
JK2ML_RS06240	COG0009	L-threonylcarbamoyladenylate synthase
JK2ML_RS06245	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
JK2ML_RS06255	COG0356	it plays a direct role in the translocation of protons across the membrane
JK2ML_RS06265	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
JK2ML_RS06285	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
JK2ML_RS06305	COG2096	Adenosyltransferase
JK2ML_RS06310	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
JK2ML_RS06330	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
JK2ML_RS06355	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
JK2ML_RS06370	COG0183	Belongs to the thiolase family
JK2ML_RS06410	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
JK2ML_RS06420	COG3191	aminopeptidase activity
JK2ML_RS06440	COG0705	Rhomboid family
JK2ML_RS06450	COG1234	tRNA 3'-trailer cleavage
JK2ML_RS06460	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
JK2ML_RS06470	COG1566	PFAM secretion protein HlyD family protein
JK2ML_RS06530	COG4842	Belongs to the WXG100 family
JK2ML_RS06605	COG3757	hydrolase, family 25
JK2ML_RS06620	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JK2ML_RS06635	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
JK2ML_RS06650	COG0252	asparaginase activity
JK2ML_RS06685	COG0587	DNA-directed DNA polymerase activity
JK2ML_RS06700	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
JK2ML_RS06740	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
JK2ML_RS06780	COG0494	nUDIX hydrolase
JK2ML_RS06790	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
JK2ML_RS06795	COG0157	Belongs to the NadC ModD family
JK2ML_RS06815	COG3321	synthase
JK2ML_RS06815	COG1028	Short-chain dehydrogenase reductase Sdr
JK2ML_RS06815	COG0604	alcohol dehydrogenase
JK2ML_RS06825	COG2409	Drug exporters of the RND superfamily
JK2ML_RS06830	COG5651	PPE family
JK2ML_RS06840	COG0318	PFAM AMP-dependent synthetase and ligase
JK2ML_RS06870	COG0488	(ABC) transporter
JK2ML_RS06875	COG1024	Enoyl-CoA hydratase
JK2ML_RS06940	COG2902	Dehydrogenase
JK2ML_RS06955	COG2346	COG2346, Truncated hemoglobins
JK2ML_RS06995	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
JK2ML_RS07010	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
JK2ML_RS07015	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
JK2ML_RS07040	COG0387	Pfam Sodium calcium exchanger
JK2ML_RS07050	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
JK2ML_RS07065	COG0133	tryptophan synthase activity
JK2ML_RS07100	COG1946	Acyl-CoA thioesterase
JK2ML_RS07165	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JK2ML_RS07185	COG0167	dihydroorotate dehydrogenase activity
JK2ML_RS07225	COG1218	3'(2'),5'-bisphosphate nucleotidase
JK2ML_RS07230	COG0215	cysteine-tRNA ligase activity
JK2ML_RS07255	COG1410	methionine synthase
JK2ML_RS07255	COG0646	methionine synthase
JK2ML_RS07275	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
JK2ML_RS07380	COG2378	regulation of single-species biofilm formation
JK2ML_RS07385	COG2378	regulation of single-species biofilm formation
JK2ML_RS07390	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
JK2ML_RS07395	COG0805	protein transport
JK2ML_RS07400	COG4581	dead DEAH box helicase
JK2ML_RS07505	COG2835	tetraacyldisaccharide 4'-kinase activity
JK2ML_RS07530	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
JK2ML_RS07565	COG0497	DNA recombination
JK2ML_RS07590	COG4974	Belongs to the 'phage' integrase family
JK2ML_RS07600	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
JK2ML_RS07605	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
JK2ML_RS07610	COG1187	pseudouridine synthase activity
JK2ML_RS07620	COG1160	GTP binding
JK2ML_RS07710	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
JK2ML_RS07710	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
JK2ML_RS07730	COG0539	negative regulation of cytoplasmic translation
JK2ML_RS07735	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
JK2ML_RS07735	COG0237	dephospho-CoA kinase activity
JK2ML_RS07760	COG0556	nucleotide-excision repair
JK2ML_RS07780	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JK2ML_RS07785	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
JK2ML_RS07800	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
JK2ML_RS07835	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
JK2ML_RS07840	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JK2ML_RS07840	COG0072	phenylalanine-tRNA ligase activity
JK2ML_RS07860	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
JK2ML_RS07865	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
JK2ML_RS07870	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
JK2ML_RS07875	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
JK2ML_RS07885	COG0137	argininosuccinate synthase activity
JK2ML_RS07905	COG0604	alcohol dehydrogenase
JK2ML_RS07905	COG3321	synthase
JK2ML_RS07910	COG3321	synthase
JK2ML_RS07910	COG0604	alcohol dehydrogenase
JK2ML_RS07965	COG1752	Esterase of the alpha-beta hydrolase superfamily
JK2ML_RS07970	COG3842	ATPase activity
JK2ML_RS07975	COG0395	ABC-type sugar transport system, permease component
JK2ML_RS07980	COG1175	transmembrane transport
JK2ML_RS07985	COG1653	transport
JK2ML_RS08040	COG0604	alcohol dehydrogenase
JK2ML_RS08040	COG3321	synthase
JK2ML_RS08045	COG0604	alcohol dehydrogenase
JK2ML_RS08045	COG3321	synthase
JK2ML_RS08050	COG3321	synthase
JK2ML_RS08050	COG0604	alcohol dehydrogenase
JK2ML_RS08055	COG0604	alcohol dehydrogenase
JK2ML_RS08055	COG3321	synthase
JK2ML_RS08160	COG2755	lipolytic protein G-D-S-L family
JK2ML_RS08170	COG0799	negative regulation of ribosome biogenesis
JK2ML_RS08175	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
JK2ML_RS08220	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
JK2ML_RS08220	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
JK2ML_RS08245	COG1530	ribonuclease E activity
JK2ML_RS08260	COG0285	dihydrofolate synthase activity
JK2ML_RS08265	COG0525	valine-tRNA ligase activity
JK2ML_RS08300	COG2040	homocysteine
JK2ML_RS08305	COG0740	serine-type endopeptidase activity
JK2ML_RS08310	COG0740	serine-type endopeptidase activity
JK2ML_RS08340	COG0698	ribose 5-phosphate isomerase
JK2ML_RS08345	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
JK2ML_RS08375	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
JK2ML_RS08385	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
JK2ML_RS08415	COG1217	gtp-binding protein TYPA
JK2ML_RS08470	COG3467	pyridoxamine 5'-phosphate
JK2ML_RS08485	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
JK2ML_RS08540	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
JK2ML_RS08545	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
JK2ML_RS08590	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
JK2ML_RS08615	COG0686	Belongs to the AlaDH PNT family
JK2ML_RS08645	COG1404	Belongs to the peptidase S8 family
JK2ML_RS08675	COG1674	ftsk spoiiie
JK2ML_RS08695	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
JK2ML_RS08700	COG2977	Belongs to the P-Pant transferase superfamily
JK2ML_RS08705	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
JK2ML_RS08765	COG0195	Participates in both transcription termination and antitermination
JK2ML_RS08845	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
JK2ML_RS08890	COG0750	zinc metalloprotease
JK2ML_RS08925	COG0575	Belongs to the CDS family
JK2ML_RS08935	COG0528	UMP kinase activity
JK2ML_RS08965	COG0154	amidase activity
JK2ML_RS08975	COG0052	Belongs to the universal ribosomal protein uS2 family
JK2ML_RS08980	COG4974	Belongs to the 'phage' integrase family
JK2ML_RS08985	COG2192	nodulation
JK2ML_RS09030	COG0792	nuclease activity
JK2ML_RS09065	COG0681	Belongs to the peptidase S26 family
JK2ML_RS09080	COG0336	Belongs to the RNA methyltransferase TrmD family
JK2ML_RS09090	COG1837	Belongs to the UPF0109 family
JK2ML_RS09120	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
JK2ML_RS09125	COG0326	Molecular chaperone. Has ATPase activity
JK2ML_RS09130	COG1061	Type III restriction enzyme res subunit
JK2ML_RS09150	COG0552	protein localization to endoplasmic reticulum
JK2ML_RS09155	COG1196	nuclear chromosome segregation
JK2ML_RS09165	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
JK2ML_RS09190	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
JK2ML_RS09210	COG1579	Zn-ribbon protein possibly nucleic acid-binding
JK2ML_RS09215	COG3323	Protein of unknown function (DUF1653)
JK2ML_RS09215	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
JK2ML_RS09310	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
JK2ML_RS09315	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
JK2ML_RS09320	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
JK2ML_RS09340	COG0571	ribonuclease III activity
JK2ML_RS09345	COG1399	metal-binding, possibly nucleic acid-binding protein
JK2ML_RS09350	COG3599	regulation of cell shape
JK2ML_RS09370	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
JK2ML_RS09375	COG0742	ribosomal rna small subunit methyltransferase
JK2ML_RS09415	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
JK2ML_RS09450	COG1181	Belongs to the D-alanine--D-alanine ligase family
JK2ML_RS09455	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
JK2ML_RS09475	COG0776	regulation of translation
JK2ML_RS09485	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
JK2ML_RS09510	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
JK2ML_RS09515	COG0179	Fumarylacetoacetate (FAA) hydrolase
JK2ML_RS09530	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
JK2ML_RS09545	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
JK2ML_RS09550	COG0440	acetolactate synthase activity
JK2ML_RS09555	COG0028	Belongs to the TPP enzyme family
JK2ML_RS09580	COG0205	6-phosphofructokinase activity
JK2ML_RS09585	COG0154	amidase activity
JK2ML_RS09630	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
JK2ML_RS09635	COG2086	electron transfer activity
JK2ML_RS09685	COG0110	maltose O-acetyltransferase activity
JK2ML_RS09690	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
JK2ML_RS09705	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
JK2ML_RS09735	COG1119	ATPase activity
JK2ML_RS09745	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
JK2ML_RS09760	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
JK2ML_RS09770	COG1309	transcriptional regulator
JK2ML_RS09775	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
JK2ML_RS09905	COG2076	Multidrug Resistance protein
JK2ML_RS09965	COG1175	transmembrane transport
JK2ML_RS09970	COG0395	ABC-type sugar transport system, permease component
JK2ML_RS10145	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
JK2ML_RS10155	COG0071	Belongs to the small heat shock protein (HSP20) family
JK2ML_RS10160	COG3707	response regulator
JK2ML_RS10210	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
JK2ML_RS10215	COG1028	Short-chain dehydrogenase reductase Sdr
JK2ML_RS10230	COG0714	Associated with various cellular activities
JK2ML_RS10240	COG0791	NLP P60 protein
JK2ML_RS10240	COG3883	PFAM NLP P60 protein
JK2ML_RS10250	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
JK2ML_RS10265	COG0488	(ABC) transporter
JK2ML_RS10275	COG3118	belongs to the thioredoxin family
JK2ML_RS10365	COG0201	protein transport
JK2ML_RS10395	COG0616	signal peptide processing
JK2ML_RS10415	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
JK2ML_RS10445	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
JK2ML_RS10470	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
JK2ML_RS10475	COG0255	Belongs to the universal ribosomal protein uL29 family
JK2ML_RS10485	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
JK2ML_RS10495	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
JK2ML_RS10515	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
JK2ML_RS10655	COG1127	ABC transporter
JK2ML_RS10670	COG0222	ribosome binding
JK2ML_RS10695	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
JK2ML_RS10710	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
JK2ML_RS10735	COG0250	Participates in transcription elongation, termination and antitermination
JK2ML_RS10740	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
JK2ML_RS10750	COG2030	dehydratase
JK2ML_RS10755	COG2030	dehydratase
JK2ML_RS10760	COG2030	dehydratase
JK2ML_RS10785	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JK2ML_RS10870	COG2032	superoxide dismutase activity
JK2ML_RS10940	COG0012	GTP binding
JK2ML_RS10950	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
JK2ML_RS10960	COG1570	exodeoxyribonuclease VII activity
JK2ML_RS10965	COG1722	exodeoxyribonuclease VII activity
JK2ML_RS11005	COG0726	polysaccharide deacetylase
JK2ML_RS11010	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
JK2ML_RS11035	COG0101	tRNA pseudouridine synthase activity
JK2ML_RS11045	COG0202	RNA polymerase activity
JK2ML_RS11070	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
JK2ML_RS11130	COG0300	oxidoreductase activity
JK2ML_RS11185	COG2217	Heavy metal translocating P-type atpase
JK2ML_RS11235	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
JK2ML_RS11245	COG3336	cytochrome c oxidase
JK2ML_RS11255	COG2217	Heavy metal translocating P-type atpase
JK2ML_RS11320	COG1950	PFAM Membrane protein of
JK2ML_RS11335	COG1058	Belongs to the CinA family
JK2ML_RS11335	COG1546	Belongs to the CinA family
JK2ML_RS11360	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
JK2ML_RS11405	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
JK2ML_RS11410	COG1652	LysM domain
JK2ML_RS11465	COG2193	ferroxidase activity
JK2ML_RS11490	COG0583	DNA-binding transcription factor activity
JK2ML_RS11565	COG2261	transglycosylase associated protein
JK2ML_RS11620	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
JK2ML_RS11625	COG0517	IMP dehydrogenase activity
JK2ML_RS11625	COG0516	GMP reductase activity
JK2ML_RS11705	COG0653	protein targeting
JK2ML_RS11730	COG2124	cytochrome p450
JK2ML_RS11760	COG0581	inorganic phosphate transmembrane transporter activity
JK2ML_RS11765	COG0573	inorganic phosphate transmembrane transporter activity
JK2ML_RS11770	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
JK2ML_RS11785	COG1914	H( )-stimulated, divalent metal cation uptake system
JK2ML_RS11900	COG1024	Enoyl-CoA hydratase
JK2ML_RS11930	COG0745	RESPONSE REGULATOR receiver
JK2ML_RS11935	COG2205	protein histidine kinase activity
JK2ML_RS11980	COG0259	pyridoxamine-phosphate oxidase activity
JK2ML_RS11995	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
JK2ML_RS11995	COG0493	'glutamate synthase
JK2ML_RS12005	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
JK2ML_RS12025	COG1846	Transcriptional regulator
JK2ML_RS12040	COG2814	Major facilitator Superfamily
JK2ML_RS12065	COG1278	Cold shock
JK2ML_RS12175	COG1250	3-hydroxyacyl-CoA dehydrogenase
JK2ML_RS12175	COG1024	Enoyl-CoA hydratase
JK2ML_RS12180	COG0183	Belongs to the thiolase family
JK2ML_RS12195	COG3961	Belongs to the TPP enzyme family
JK2ML_RS12320	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
JK2ML_RS12330	COG0704	Plays a role in the regulation of phosphate uptake
JK2ML_RS12335	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
JK2ML_RS12380	COG2897	thiosulfate sulfurtransferase activity
JK2ML_RS12390	COG4044	May play a role in the intracellular transport of hydrophobic ligands
JK2ML_RS12410	COG0354	folic acid binding
JK2ML_RS12420	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
JK2ML_RS12425	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
JK2ML_RS12440	COG0438	transferase activity, transferring glycosyl groups
JK2ML_RS12460	COG1362	aminopeptidase activity
JK2ML_RS12485	COG0047	phosphoribosylformylglycinamidine synthase activity
JK2ML_RS12490	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
JK2ML_RS12545	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
JK2ML_RS12570	COG0151	Belongs to the GarS family
JK2ML_RS12585	COG0537	adenosine 5'-monophosphoramidase activity
JK2ML_RS12665	COG1316	TRANSCRIPTIONal
JK2ML_RS12705	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
JK2ML_RS12740	COG0306	phosphate transporter
JK2ML_RS12780	COG4948	Mandelate Racemase Muconate Lactonizing
JK2ML_RS12805	COG2226	methyltransferase
JK2ML_RS12820	COG0142	geranyltranstransferase activity
JK2ML_RS12830	COG0659	secondary active sulfate transmembrane transporter activity
JK2ML_RS12945	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
JK2ML_RS12960	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JK2ML_RS12965	COG0251	oxidation-reduction process
JK2ML_RS12995	COG1408	metallophosphoesterase
JK2ML_RS13025	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
JK2ML_RS13045	COG1262	PFAM Formylglycine-generating sulfatase enzyme
JK2ML_RS13095	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
JK2ML_RS13105	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
JK2ML_RS13120	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
JK2ML_RS13130	COG0860	N-Acetylmuramoyl-L-alanine amidase
JK2ML_RS13145	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
JK2ML_RS13155	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JK2ML_RS13240	COG1819	glycosyl
JK2ML_RS13245	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
JK2ML_RS13275	COG0604	alcohol dehydrogenase
JK2ML_RS13275	COG1028	Short-chain dehydrogenase reductase Sdr
JK2ML_RS13275	COG3321	synthase
JK2ML_RS13290	COG0318	PFAM AMP-dependent synthetase and ligase
JK2ML_RS13295	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
JK2ML_RS13350	COG5416	Lipopolysaccharide assembly protein A domain
JK2ML_RS13370	COG5651	PPE family
JK2ML_RS13390	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
JK2ML_RS13420	COG2409	Drug exporters of the RND superfamily
JK2ML_RS13420	COG1033	growth of symbiont in host cell
JK2ML_RS13460	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
JK2ML_RS13495	COG0626	cystathionine gamma-synthase activity
JK2ML_RS13500	COG1714	RDD family
JK2ML_RS13525	COG0183	Belongs to the thiolase family
JK2ML_RS13540	COG1024	Enoyl-CoA hydratase
JK2ML_RS13555	COG1575	Belongs to the MenA family. Type 1 subfamily
JK2ML_RS13575	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
JK2ML_RS13585	COG0785	Cytochrome C biogenesis protein
JK2ML_RS13595	COG0406	alpha-ribazole phosphatase activity
JK2ML_RS13635	COG0113	porphobilinogen synthase activity
JK2ML_RS13645	COG0181	hydroxymethylbilane synthase activity
JK2ML_RS13650	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
JK2ML_RS13665	COG0560	Phosphoserine phosphatase
JK2ML_RS13670	COG2030	dehydratase
JK2ML_RS13675	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
JK2ML_RS13680	COG0204	Acyl-transferase
JK2ML_RS13700	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
JK2ML_RS13710	COG1082	Xylose isomerase domain protein TIM barrel
JK2ML_RS13720	COG0248	Ppx GppA phosphatase
JK2ML_RS13755	COG5002	protein histidine kinase activity
JK2ML_RS13890	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
JK2ML_RS13940	COG0287	Prephenate dehydrogenase
JK2ML_RS13950	COG0590	tRNA wobble adenosine to inosine editing
JK2ML_RS13965	COG0393	Putative heavy-metal-binding
JK2ML_RS13970	COG0393	Putative heavy-metal-binding
JK2ML_RS14045	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
JK2ML_RS14055	COG0542	response to heat
JK2ML_RS14070	COG0789	Transcriptional regulator
JK2ML_RS14075	COG0484	heat shock protein binding
JK2ML_RS14080	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
JK2ML_RS14115	COG2181	nitrate reductase activity
JK2ML_RS14115	COG0247	lactate metabolic process
JK2ML_RS14240	COG1404	Belongs to the peptidase S8 family
JK2ML_RS14255	COG4842	Belongs to the WXG100 family
JK2ML_RS14285	COG0464	growth
JK2ML_RS14340	COG0318	PFAM AMP-dependent synthetase and ligase
JK2ML_RS14360	COG1984	allophanate hydrolase subunit 2
JK2ML_RS14435	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
JK2ML_RS14450	COG1960	acyl-CoA dehydrogenase activity
JK2ML_RS14470	COG2030	dehydratase
JK2ML_RS14485	COG1472	Belongs to the glycosyl hydrolase 3 family
JK2ML_RS14495	COG4981	capsule polysaccharide biosynthetic process
JK2ML_RS14515	COG1012	belongs to the aldehyde dehydrogenase family
JK2ML_RS14585	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
JK2ML_RS14590	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
JK2ML_RS14615	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
JK2ML_RS14665	COG2267	carboxylic ester hydrolase activity
JK2ML_RS14700	COG0129	dihydroxy-acid dehydratase activity
JK2ML_RS14705	COG1937	Protein conserved in bacteria
JK2ML_RS14720	COG3590	peptidase
JK2ML_RS14740	COG2409	Drug exporters of the RND superfamily
JK2ML_RS14755	COG2409	Drug exporters of the RND superfamily
JK2ML_RS14790	COG2030	dehydratase
JK2ML_RS14815	COG0277	FAD linked oxidase domain protein
JK2ML_RS14860	COG1012	belongs to the aldehyde dehydrogenase family
JK2ML_RS14865	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
JK2ML_RS14925	COG0772	Belongs to the SEDS family
JK2ML_RS14955	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
JK2ML_RS14980	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
JK2ML_RS15000	COG0583	DNA-binding transcription factor activity
JK2ML_RS15005	COG1376	ErfK ybiS ycfS ynhG family protein
JK2ML_RS15035	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
JK2ML_RS15035	COG2755	lipolytic protein G-D-S-L family
JK2ML_RS15050	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
JK2ML_RS15115	COG0305	Participates in initiation and elongation during chromosome replication
JK2ML_RS15130	COG0629	single-stranded DNA binding
JK2ML_RS15135	COG0360	Binds together with S18 to 16S ribosomal RNA
JK2ML_RS15150	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
JK2ML_RS15165	COG1260	myo-inositol-1-phosphate synthase
JK2ML_RS15200	COG0617	tRNA 3'-terminal CCA addition
JK2ML_RS15225	COG0492	ferredoxin-NADP+ reductase activity
JK2ML_RS15225	COG3118	belongs to the thioredoxin family
JK2ML_RS15230	COG3409	Peptidoglycan-binding domain 1 protein
JK2ML_RS15230	COG0860	N-Acetylmuramoyl-L-alanine amidase
JK2ML_RS15240	COG1475	DNA binding
JK2ML_RS15245	COG1192	Involved in chromosome partitioning
JK2ML_RS15260	COG0706	membrane insertase activity