locus-tag	class	description
DIJ64_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DIJ64_RS00010	COG0592	DNA-directed DNA polymerase activity
DIJ64_RS00025	COG0187	DNA topoisomerase II activity
DIJ64_RS00030	COG1372	Participates in initiation and elongation during chromosome replication
DIJ64_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DIJ64_RS00060	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DIJ64_RS00085	COG0515	serine threonine protein kinase
DIJ64_RS00085	COG2815	serine threonine protein kinase
DIJ64_RS00090	COG0515	serine threonine protein kinase
DIJ64_RS00100	COG0772	Belongs to the SEDS family
DIJ64_RS00115	COG1716	ATPase activity
DIJ64_RS00150	COG1678	Uncharacterized ACR, COG1678
DIJ64_RS00195	COG1404	Belongs to the peptidase S8 family
DIJ64_RS00230	COG4842	Belongs to the WXG100 family
DIJ64_RS00235	COG4842	Belongs to the WXG100 family
DIJ64_RS00260	COG0464	growth
DIJ64_RS00300	COG0070	glutamate synthase
DIJ64_RS00300	COG0069	glutamate synthase activity
DIJ64_RS00300	COG0067	glutamate synthase
DIJ64_RS00370	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DIJ64_RS00460	COG0561	phosphatase activity
DIJ64_RS00480	COG1216	Glycosyl transferase, family 2
DIJ64_RS00495	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
DIJ64_RS00500	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
DIJ64_RS00505	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
DIJ64_RS00510	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
DIJ64_RS00525	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DIJ64_RS00540	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
DIJ64_RS00545	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
DIJ64_RS00555	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
DIJ64_RS00575	COG2246	polysaccharide biosynthetic process
DIJ64_RS00610	COG0604	alcohol dehydrogenase
DIJ64_RS00610	COG3321	synthase
DIJ64_RS00610	COG1028	Short-chain dehydrogenase reductase Sdr
DIJ64_RS00620	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DIJ64_RS00665	COG3510	cephalosporin hydroxylase
DIJ64_RS00670	COG3268	Saccharopine dehydrogenase
DIJ64_RS00675	COG2226	methyltransferase
DIJ64_RS00680	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DIJ64_RS00685	COG0318	PFAM AMP-dependent synthetase and ligase
DIJ64_RS00690	COG3161	chorismate lyase activity
DIJ64_RS00755	COG0657	acetylesterase activity
DIJ64_RS00790	COG0210	DNA helicase
DIJ64_RS00800	COG0739	heme binding
DIJ64_RS00925	COG0745	RESPONSE REGULATOR receiver
DIJ64_RS00930	COG3850	Histidine kinase
DIJ64_RS00930	COG0642	Histidine kinase
DIJ64_RS00935	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DIJ64_RS00940	COG0521	Mo-molybdopterin cofactor biosynthetic process
DIJ64_RS00940	COG0315	cyclic pyranopterin monophosphate synthase activity
DIJ64_RS00960	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DIJ64_RS00965	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DIJ64_RS00995	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DIJ64_RS00995	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DIJ64_RS01060	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DIJ64_RS01060	COG1754	DNA topoisomerase type I activity
DIJ64_RS01070	COG0470	DNA polymerase III
DIJ64_RS01115	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
DIJ64_RS01120	COG2027	D-alanyl-D-alanine carboxypeptidase
DIJ64_RS01130	COG0037	tRNA processing
DIJ64_RS01135	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
DIJ64_RS01180	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DIJ64_RS01190	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DIJ64_RS01195	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
DIJ64_RS01200	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DIJ64_RS01220	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
DIJ64_RS01235	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DIJ64_RS01245	COG0542	response to heat
DIJ64_RS01260	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DIJ64_RS01265	COG0084	hydrolase, TatD family'
DIJ64_RS01285	COG0318	PFAM AMP-dependent synthetase and ligase
DIJ64_RS01295	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
DIJ64_RS01310	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DIJ64_RS01350	COG0148	phosphopyruvate hydratase activity
DIJ64_RS01465	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DIJ64_RS01485	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DIJ64_RS01520	COG1230	cation diffusion facilitator family transporter
DIJ64_RS01535	COG0191	fructose-bisphosphate aldolase activity
DIJ64_RS01540	COG0586	Pfam SNARE associated Golgi protein
DIJ64_RS01570	COG0351	phosphomethylpyrimidine kinase
DIJ64_RS01605	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DIJ64_RS01610	COG0515	serine threonine protein kinase
DIJ64_RS01635	COG1183	phosphatidylcholine synthase activity
DIJ64_RS01675	COG0657	acetylesterase activity
DIJ64_RS01690	COG4221	oxidoreductase activity
DIJ64_RS01700	COG0459	protein refolding
DIJ64_RS01710	COG2847	Copper chaperone PCu(A)C
DIJ64_RS01805	COG1121	(ABC) transporter
DIJ64_RS01860	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DIJ64_RS01885	COG0028	Belongs to the TPP enzyme family
DIJ64_RS01925	COG4842	Belongs to the WXG100 family
DIJ64_RS01970	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DIJ64_RS01975	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DIJ64_RS01975	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
DIJ64_RS01985	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DIJ64_RS01995	COG0802	atpase or kinase
DIJ64_RS02000	COG1214	PFAM Peptidase M22, glycoprotease
DIJ64_RS02000	COG0456	acetyltransferase
DIJ64_RS02005	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DIJ64_RS02015	COG0459	protein refolding
DIJ64_RS02055	COG0516	GMP reductase activity
DIJ64_RS02055	COG0517	IMP dehydrogenase activity
DIJ64_RS02060	COG0516	GMP reductase activity
DIJ64_RS02080	COG1554	hydrolase, family 65, central catalytic
DIJ64_RS02085	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DIJ64_RS02100	COG1172	Belongs to the binding-protein-dependent transport system permease family
DIJ64_RS02110	COG1879	ABC-type sugar transport system periplasmic component
DIJ64_RS02160	COG3328	transposase activity
DIJ64_RS02185	COG5651	PPE family
DIJ64_RS02200	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DIJ64_RS02200	COG1877	trehalose-phosphatase activity
DIJ64_RS02225	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
DIJ64_RS02290	COG1376	ErfK ybiS ycfS ynhG family protein
DIJ64_RS02300	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
DIJ64_RS02310	COG0300	oxidoreductase activity
DIJ64_RS02385	COG0508	dehydrogenase complex catalyzes the overall conversion of
DIJ64_RS02425	COG0438	transferase activity, transferring glycosyl groups
DIJ64_RS02450	COG0667	Aldo Keto reductase
DIJ64_RS02490	COG0586	Pfam SNARE associated Golgi protein
DIJ64_RS02540	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
DIJ64_RS02580	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
DIJ64_RS02600	COG1022	Amp-dependent synthetase and ligase
DIJ64_RS02600	COG3320	Male sterility
DIJ64_RS02605	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DIJ64_RS02610	COG1862	Preprotein translocase
DIJ64_RS02615	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DIJ64_RS02620	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DIJ64_RS02625	COG0747	negative chemotaxis
DIJ64_RS02635	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DIJ64_RS02640	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DIJ64_RS02645	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DIJ64_RS02650	COG0124	histidyl-tRNA synthetase
DIJ64_RS02655	COG0657	acetylesterase activity
DIJ64_RS02775	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DIJ64_RS02800	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DIJ64_RS02805	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DIJ64_RS02885	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DIJ64_RS02895	COG0505	Belongs to the CarA family
DIJ64_RS02900	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DIJ64_RS02930	COG0194	GDP metabolic process
DIJ64_RS02970	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DIJ64_RS03000	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DIJ64_RS03010	COG0477	Major facilitator Superfamily
DIJ64_RS03050	COG0391	Required for morphogenesis under gluconeogenic growth conditions
DIJ64_RS03105	COG1376	ErfK ybiS ycfS ynhG family protein
DIJ64_RS03110	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DIJ64_RS03120	COG0149	triose-phosphate isomerase activity
DIJ64_RS03145	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DIJ64_RS03155	COG0363	glucosamine-6-phosphate deaminase activity
DIJ64_RS03175	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DIJ64_RS03180	COG0109	protoheme IX farnesyltransferase activity
DIJ64_RS03210	COG1131	(ABC) transporter
DIJ64_RS03230	COG1372	Participates in initiation and elongation during chromosome replication
DIJ64_RS03230	COG0719	Fe-S assembly protein
DIJ64_RS03235	COG0719	Fe-S assembly protein
DIJ64_RS03240	COG0396	ATPase activity
DIJ64_RS03245	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DIJ64_RS03250	COG0822	iron-sulfur transferase activity
DIJ64_RS03255	COG2151	metal-sulfur cluster biosynthetic enzyme
DIJ64_RS03310	COG2308	Evidence 4 Homologs of previously reported genes of
DIJ64_RS03320	COG1305	Transglutaminase-like
DIJ64_RS03415	COG0484	heat shock protein binding
DIJ64_RS03425	COG1702	phosphate starvation-inducible protein PhoH
DIJ64_RS03445	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DIJ64_RS03460	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DIJ64_RS03470	COG0210	DNA helicase
DIJ64_RS03485	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DIJ64_RS03500	COG3480	Lon protease (S16) C-terminal proteolytic domain
DIJ64_RS03595	COG1960	acyl-CoA dehydrogenase activity
DIJ64_RS03605	COG0483	inositol monophosphate 1-phosphatase activity
DIJ64_RS03625	COG0493	'glutamate synthase
DIJ64_RS03650	COG2884	Cell division ATP-binding protein ftsE
DIJ64_RS03655	COG2177	Part of the ABC transporter FtsEX involved in
DIJ64_RS03735	COG0180	Tryptophanyl-tRNA synthetase
DIJ64_RS03775	COG1686	Belongs to the peptidase S11 family
DIJ64_RS03815	COG1053	succinate dehydrogenase
DIJ64_RS03825	COG2009	succinate dehydrogenase
DIJ64_RS03860	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DIJ64_RS03865	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
DIJ64_RS03895	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DIJ64_RS03920	COG1309	transcriptional regulator
DIJ64_RS03970	COG4770	biotin carboxylase activity
DIJ64_RS03980	COG2897	thiosulfate sulfurtransferase activity
DIJ64_RS03995	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DIJ64_RS04000	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
DIJ64_RS04000	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
DIJ64_RS04015	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
DIJ64_RS04020	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
DIJ64_RS04025	COG1960	acyl-CoA dehydrogenase activity
DIJ64_RS04070	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
DIJ64_RS04075	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
DIJ64_RS04085	COG2217	Heavy metal translocating P-type atpase
DIJ64_RS04100	COG1316	TRANSCRIPTIONal
DIJ64_RS04140	COG0778	Nitroreductase
DIJ64_RS04140	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
DIJ64_RS04145	COG0391	Required for morphogenesis under gluconeogenic growth conditions
DIJ64_RS04170	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DIJ64_RS04180	COG1482	cell wall glycoprotein biosynthetic process
DIJ64_RS04220	COG0745	RESPONSE REGULATOR receiver
DIJ64_RS04225	COG5002	protein histidine kinase activity
DIJ64_RS04225	COG5000	phosphorelay sensor kinase activity
DIJ64_RS04230	COG5401	PFAM Sporulation and spore germination
DIJ64_RS04245	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
DIJ64_RS04250	COG0653	protein targeting
DIJ64_RS04300	COG1162	GTPase activity
DIJ64_RS04305	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DIJ64_RS04310	COG2135	peptidase activity
DIJ64_RS04370	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
DIJ64_RS04415	COG0513	Belongs to the DEAD box helicase family
DIJ64_RS04510	COG0232	Belongs to the dGTPase family. Type 2 subfamily
DIJ64_RS04520	COG0358	DNA primase activity
DIJ64_RS04555	COG1045	serine acetyltransferase
DIJ64_RS04560	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DIJ64_RS04570	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DIJ64_RS04575	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DIJ64_RS04585	COG2223	nitrite transmembrane transporter activity
DIJ64_RS04635	COG0612	Peptidase, M16
DIJ64_RS04660	COG1090	epimerase
DIJ64_RS04680	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DIJ64_RS04690	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DIJ64_RS04725	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DIJ64_RS04735	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DIJ64_RS04755	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DIJ64_RS04765	COG2010	Cytochrome c
DIJ64_RS04770	COG1845	cytochrome c oxidase, subunit III
DIJ64_RS04800	COG1022	Amp-dependent synthetase and ligase
DIJ64_RS04815	COG0003	Pfam Anion-transporting ATPase
DIJ64_RS04845	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
DIJ64_RS04905	COG0768	penicillin binding
DIJ64_RS04910	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DIJ64_RS04915	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DIJ64_RS04920	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DIJ64_RS04955	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DIJ64_RS04960	COG1496	oxidoreductase activity
DIJ64_RS04965	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DIJ64_RS04980	COG3599	regulation of cell shape
DIJ64_RS05100	COG1309	transcriptional regulator
DIJ64_RS05135	COG0574	Belongs to the PEP-utilizing enzyme family
DIJ64_RS05135	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DIJ64_RS05170	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DIJ64_RS05250	COG1674	ftsk spoiiie
DIJ64_RS05255	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
DIJ64_RS05285	COG4308	Limonene-1,2-epoxide hydrolase catalytic domain
DIJ64_RS05300	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DIJ64_RS05300	COG1372	Participates in initiation and elongation during chromosome replication
DIJ64_RS05310	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DIJ64_RS05350	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DIJ64_RS05385	COG1388	LysM domain
DIJ64_RS05395	COG4044	May play a role in the intracellular transport of hydrophobic ligands
DIJ64_RS05430	COG1321	iron dependent repressor
DIJ64_RS05470	COG1940	carbohydrate kinase activity
DIJ64_RS05475	COG0483	inositol monophosphate 1-phosphatase activity
DIJ64_RS05535	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
DIJ64_RS05570	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
DIJ64_RS05605	COG0318	PFAM AMP-dependent synthetase and ligase
DIJ64_RS05640	COG1611	Belongs to the LOG family
DIJ64_RS05645	COG0318	PFAM AMP-dependent synthetase and ligase
DIJ64_RS05650	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DIJ64_RS05655	COG0463	Glycosyl transferase, family 2
DIJ64_RS05665	COG0519	Catalyzes the synthesis of GMP from XMP
DIJ64_RS05720	COG5662	AntiSigma factor
DIJ64_RS05725	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DIJ64_RS05735	COG0489	protein tyrosine kinase activity
DIJ64_RS05735	COG2151	metal-sulfur cluster biosynthetic enzyme
DIJ64_RS05790	COG0598	Magnesium transport protein CorA
DIJ64_RS05795	COG0039	L-malate dehydrogenase activity
DIJ64_RS05830	COG0508	dehydrogenase complex catalyzes the overall conversion of
DIJ64_RS05830	COG0567	Dehydrogenase, E1 component
DIJ64_RS05895	COG0277	FAD linked oxidase domain protein
DIJ64_RS05905	COG1573	uracil-dna glycosylase
DIJ64_RS05970	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
DIJ64_RS05980	COG2062	phosphohistidine phosphatase, SixA
DIJ64_RS06070	COG0019	diaminopimelate decarboxylase activity
DIJ64_RS06075	COG0460	homoserine dehydrogenase
DIJ64_RS06080	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
DIJ64_RS06095	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DIJ64_RS06110	COG2890	protein-(glutamine-N5) methyltransferase activity
DIJ64_RS06115	COG0009	L-threonylcarbamoyladenylate synthase
DIJ64_RS06120	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DIJ64_RS06130	COG0356	it plays a direct role in the translocation of protons across the membrane
DIJ64_RS06140	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DIJ64_RS06160	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DIJ64_RS06180	COG2096	Adenosyltransferase
DIJ64_RS06185	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DIJ64_RS06205	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DIJ64_RS06230	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
DIJ64_RS06245	COG0183	Belongs to the thiolase family
DIJ64_RS06285	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
DIJ64_RS06295	COG3191	aminopeptidase activity
DIJ64_RS06315	COG0705	Rhomboid family
DIJ64_RS06325	COG1234	tRNA 3'-trailer cleavage
DIJ64_RS06335	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DIJ64_RS06345	COG1566	PFAM secretion protein HlyD family protein
DIJ64_RS06460	COG3757	hydrolase, family 25
DIJ64_RS06475	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DIJ64_RS06490	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DIJ64_RS06505	COG0252	asparaginase activity
DIJ64_RS06540	COG0587	DNA-directed DNA polymerase activity
DIJ64_RS06550	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DIJ64_RS06590	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DIJ64_RS06630	COG0494	nUDIX hydrolase
DIJ64_RS06640	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
DIJ64_RS06645	COG0157	Belongs to the NadC ModD family
DIJ64_RS06670	COG0604	alcohol dehydrogenase
DIJ64_RS06670	COG1028	Short-chain dehydrogenase reductase Sdr
DIJ64_RS06670	COG3321	synthase
DIJ64_RS06680	COG2409	Drug exporters of the RND superfamily
DIJ64_RS06685	COG5651	PPE family
DIJ64_RS06695	COG0318	PFAM AMP-dependent synthetase and ligase
DIJ64_RS06725	COG1024	Enoyl-CoA hydratase
DIJ64_RS06790	COG2902	Dehydrogenase
DIJ64_RS06805	COG2346	COG2346, Truncated hemoglobins
DIJ64_RS06840	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DIJ64_RS06855	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DIJ64_RS06860	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DIJ64_RS06885	COG0387	Pfam Sodium calcium exchanger
DIJ64_RS06895	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DIJ64_RS06910	COG0133	tryptophan synthase activity
DIJ64_RS06945	COG1946	Acyl-CoA thioesterase
DIJ64_RS07005	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DIJ64_RS07025	COG0167	dihydroorotate dehydrogenase activity
DIJ64_RS07065	COG1218	3'(2'),5'-bisphosphate nucleotidase
DIJ64_RS07070	COG0215	cysteine-tRNA ligase activity
DIJ64_RS07095	COG0646	methionine synthase
DIJ64_RS07095	COG1410	methionine synthase
DIJ64_RS07115	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DIJ64_RS07225	COG2378	regulation of single-species biofilm formation
DIJ64_RS07230	COG2378	regulation of single-species biofilm formation
DIJ64_RS07235	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DIJ64_RS07240	COG0805	protein transport
DIJ64_RS07245	COG4581	dead DEAH box helicase
DIJ64_RS07340	COG2835	tetraacyldisaccharide 4'-kinase activity
DIJ64_RS07365	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DIJ64_RS07400	COG0497	DNA recombination
DIJ64_RS07425	COG4974	Belongs to the 'phage' integrase family
DIJ64_RS07435	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
DIJ64_RS07440	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DIJ64_RS07445	COG1187	pseudouridine synthase activity
DIJ64_RS07455	COG1160	GTP binding
DIJ64_RS07540	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DIJ64_RS07540	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DIJ64_RS07550	COG0539	negative regulation of cytoplasmic translation
DIJ64_RS07555	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
DIJ64_RS07555	COG0237	dephospho-CoA kinase activity
DIJ64_RS07580	COG0556	nucleotide-excision repair
DIJ64_RS07600	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DIJ64_RS07605	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DIJ64_RS07620	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DIJ64_RS07655	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DIJ64_RS07660	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DIJ64_RS07660	COG0072	phenylalanine-tRNA ligase activity
DIJ64_RS07680	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
DIJ64_RS07685	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DIJ64_RS07690	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DIJ64_RS07695	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DIJ64_RS07705	COG0137	argininosuccinate synthase activity
DIJ64_RS07725	COG3321	synthase
DIJ64_RS07725	COG0604	alcohol dehydrogenase
DIJ64_RS07730	COG0604	alcohol dehydrogenase
DIJ64_RS07730	COG3321	synthase
DIJ64_RS07785	COG1752	Esterase of the alpha-beta hydrolase superfamily
DIJ64_RS07790	COG3842	ATPase activity
DIJ64_RS07795	COG0395	ABC-type sugar transport system, permease component
DIJ64_RS07800	COG1175	transmembrane transport
DIJ64_RS07805	COG1653	transport
DIJ64_RS07955	COG2755	lipolytic protein G-D-S-L family
DIJ64_RS07965	COG0799	negative regulation of ribosome biogenesis
DIJ64_RS07970	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DIJ64_RS08025	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DIJ64_RS08025	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DIJ64_RS08050	COG1530	ribonuclease E activity
DIJ64_RS08065	COG0285	dihydrofolate synthase activity
DIJ64_RS08070	COG0525	valine-tRNA ligase activity
DIJ64_RS08110	COG2040	homocysteine
DIJ64_RS08115	COG0740	serine-type endopeptidase activity
DIJ64_RS08120	COG0740	serine-type endopeptidase activity
DIJ64_RS08150	COG0698	ribose 5-phosphate isomerase
DIJ64_RS08155	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
DIJ64_RS08175	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
DIJ64_RS08185	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
DIJ64_RS08215	COG1217	gtp-binding protein TYPA
DIJ64_RS08270	COG3467	pyridoxamine 5'-phosphate
DIJ64_RS08285	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DIJ64_RS08340	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DIJ64_RS08345	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
DIJ64_RS08390	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DIJ64_RS08415	COG0686	Belongs to the AlaDH PNT family
DIJ64_RS08440	COG1404	Belongs to the peptidase S8 family
DIJ64_RS08470	COG1674	ftsk spoiiie
DIJ64_RS08485	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DIJ64_RS08490	COG2977	Belongs to the P-Pant transferase superfamily
DIJ64_RS08495	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
DIJ64_RS08555	COG0195	Participates in both transcription termination and antitermination
DIJ64_RS08630	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
DIJ64_RS08675	COG0750	zinc metalloprotease
DIJ64_RS08710	COG0575	Belongs to the CDS family
DIJ64_RS08720	COG0528	UMP kinase activity
DIJ64_RS08755	COG0154	amidase activity
DIJ64_RS08765	COG0052	Belongs to the universal ribosomal protein uS2 family
DIJ64_RS08770	COG4974	Belongs to the 'phage' integrase family
DIJ64_RS08775	COG2192	nodulation
DIJ64_RS08820	COG0792	nuclease activity
DIJ64_RS08850	COG0681	Belongs to the peptidase S26 family
DIJ64_RS08865	COG0336	Belongs to the RNA methyltransferase TrmD family
DIJ64_RS08875	COG1837	Belongs to the UPF0109 family
DIJ64_RS08905	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DIJ64_RS08910	COG0326	Molecular chaperone. Has ATPase activity
DIJ64_RS08915	COG1061	Type III restriction enzyme res subunit
DIJ64_RS08935	COG0552	protein localization to endoplasmic reticulum
DIJ64_RS08940	COG1196	nuclear chromosome segregation
DIJ64_RS08970	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
DIJ64_RS08990	COG1579	Zn-ribbon protein possibly nucleic acid-binding
DIJ64_RS08995	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DIJ64_RS08995	COG3323	Protein of unknown function (DUF1653)
DIJ64_RS09090	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DIJ64_RS09095	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DIJ64_RS09100	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DIJ64_RS09115	COG0571	ribonuclease III activity
DIJ64_RS09120	COG1399	metal-binding, possibly nucleic acid-binding protein
DIJ64_RS09125	COG3599	regulation of cell shape
DIJ64_RS09135	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DIJ64_RS09140	COG0742	ribosomal rna small subunit methyltransferase
DIJ64_RS09180	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DIJ64_RS09215	COG1181	Belongs to the D-alanine--D-alanine ligase family
DIJ64_RS09220	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DIJ64_RS09240	COG0776	regulation of translation
DIJ64_RS09250	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DIJ64_RS09275	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DIJ64_RS09280	COG0179	Fumarylacetoacetate (FAA) hydrolase
DIJ64_RS09295	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DIJ64_RS09310	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DIJ64_RS09315	COG0440	acetolactate synthase activity
DIJ64_RS09320	COG0028	Belongs to the TPP enzyme family
DIJ64_RS09345	COG0205	6-phosphofructokinase activity
DIJ64_RS09350	COG0154	amidase activity
DIJ64_RS09395	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
DIJ64_RS09400	COG2086	electron transfer activity
DIJ64_RS09450	COG0110	maltose O-acetyltransferase activity
DIJ64_RS09455	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DIJ64_RS09485	COG1119	ATPase activity
DIJ64_RS09495	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DIJ64_RS09510	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DIJ64_RS09520	COG1309	transcriptional regulator
DIJ64_RS09525	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DIJ64_RS09670	COG2076	Multidrug Resistance protein
DIJ64_RS09730	COG1175	transmembrane transport
DIJ64_RS09735	COG0395	ABC-type sugar transport system, permease component
DIJ64_RS09900	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
DIJ64_RS09910	COG0071	Belongs to the small heat shock protein (HSP20) family
DIJ64_RS09915	COG3707	response regulator
DIJ64_RS09965	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
DIJ64_RS09970	COG1028	Short-chain dehydrogenase reductase Sdr
DIJ64_RS09985	COG0714	Associated with various cellular activities
DIJ64_RS09995	COG3883	PFAM NLP P60 protein
DIJ64_RS09995	COG0791	NLP P60 protein
DIJ64_RS10005	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
DIJ64_RS10020	COG0488	(ABC) transporter
DIJ64_RS10030	COG3118	belongs to the thioredoxin family
DIJ64_RS10100	COG0201	protein transport
DIJ64_RS10130	COG0616	signal peptide processing
DIJ64_RS10150	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
DIJ64_RS10180	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
DIJ64_RS10200	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DIJ64_RS10205	COG0255	Belongs to the universal ribosomal protein uL29 family
DIJ64_RS10215	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DIJ64_RS10225	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DIJ64_RS10245	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DIJ64_RS10380	COG1127	ABC transporter
DIJ64_RS10395	COG0222	ribosome binding
DIJ64_RS10420	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DIJ64_RS10435	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DIJ64_RS10460	COG0250	Participates in transcription elongation, termination and antitermination
DIJ64_RS10465	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DIJ64_RS10475	COG2030	dehydratase
DIJ64_RS10480	COG2030	dehydratase
DIJ64_RS10485	COG2030	dehydratase
DIJ64_RS10510	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DIJ64_RS10590	COG2032	superoxide dismutase activity
DIJ64_RS10655	COG0012	GTP binding
DIJ64_RS10665	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DIJ64_RS10675	COG1570	exodeoxyribonuclease VII activity
DIJ64_RS10680	COG1722	exodeoxyribonuclease VII activity
DIJ64_RS10715	COG0726	polysaccharide deacetylase
DIJ64_RS10720	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
DIJ64_RS10740	COG0101	tRNA pseudouridine synthase activity
DIJ64_RS10750	COG0202	RNA polymerase activity
DIJ64_RS10775	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DIJ64_RS10830	COG0300	oxidoreductase activity
DIJ64_RS10885	COG2217	Heavy metal translocating P-type atpase
DIJ64_RS10935	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DIJ64_RS10945	COG3336	cytochrome c oxidase
DIJ64_RS10955	COG2217	Heavy metal translocating P-type atpase
DIJ64_RS11020	COG1950	PFAM Membrane protein of
DIJ64_RS11035	COG1058	Belongs to the CinA family
DIJ64_RS11035	COG1546	Belongs to the CinA family
DIJ64_RS11055	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
DIJ64_RS11100	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
DIJ64_RS11105	COG1652	LysM domain
DIJ64_RS11160	COG2193	ferroxidase activity
DIJ64_RS11185	COG0583	DNA-binding transcription factor activity
DIJ64_RS11255	COG2261	transglycosylase associated protein
DIJ64_RS11305	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
DIJ64_RS11310	COG0516	GMP reductase activity
DIJ64_RS11310	COG0517	IMP dehydrogenase activity
DIJ64_RS11325	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
DIJ64_RS11390	COG0653	protein targeting
DIJ64_RS11405	COG2124	cytochrome p450
DIJ64_RS11435	COG0581	inorganic phosphate transmembrane transporter activity
DIJ64_RS11440	COG0573	inorganic phosphate transmembrane transporter activity
DIJ64_RS11445	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DIJ64_RS11460	COG1914	H( )-stimulated, divalent metal cation uptake system
DIJ64_RS11575	COG1024	Enoyl-CoA hydratase
DIJ64_RS11605	COG0745	RESPONSE REGULATOR receiver
DIJ64_RS11610	COG2205	protein histidine kinase activity
DIJ64_RS11655	COG0259	pyridoxamine-phosphate oxidase activity
DIJ64_RS11670	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
DIJ64_RS11670	COG0493	'glutamate synthase
DIJ64_RS11680	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
DIJ64_RS11700	COG1846	Transcriptional regulator
DIJ64_RS11715	COG2814	Major facilitator Superfamily
DIJ64_RS11740	COG1278	Cold shock
DIJ64_RS11840	COG1024	Enoyl-CoA hydratase
DIJ64_RS11840	COG1250	3-hydroxyacyl-CoA dehydrogenase
DIJ64_RS11845	COG0183	Belongs to the thiolase family
DIJ64_RS11860	COG3961	Belongs to the TPP enzyme family
DIJ64_RS12000	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DIJ64_RS12010	COG0704	Plays a role in the regulation of phosphate uptake
DIJ64_RS12060	COG2897	thiosulfate sulfurtransferase activity
DIJ64_RS12070	COG4044	May play a role in the intracellular transport of hydrophobic ligands
DIJ64_RS12090	COG0354	folic acid binding
DIJ64_RS12100	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DIJ64_RS12105	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
DIJ64_RS12120	COG0438	transferase activity, transferring glycosyl groups
DIJ64_RS12140	COG1362	aminopeptidase activity
DIJ64_RS12165	COG0047	phosphoribosylformylglycinamidine synthase activity
DIJ64_RS12170	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DIJ64_RS12225	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DIJ64_RS12250	COG0151	Belongs to the GarS family
DIJ64_RS12260	COG0537	adenosine 5'-monophosphoramidase activity
DIJ64_RS12330	COG1316	TRANSCRIPTIONal
DIJ64_RS12370	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
DIJ64_RS12400	COG0306	phosphate transporter
DIJ64_RS12440	COG4948	Mandelate Racemase Muconate Lactonizing
DIJ64_RS12465	COG2226	methyltransferase
DIJ64_RS12480	COG0142	geranyltranstransferase activity
DIJ64_RS12490	COG0659	secondary active sulfate transmembrane transporter activity
DIJ64_RS12615	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DIJ64_RS12630	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DIJ64_RS12635	COG0251	oxidation-reduction process
DIJ64_RS12665	COG1408	metallophosphoesterase
DIJ64_RS12695	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DIJ64_RS12715	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DIJ64_RS12760	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DIJ64_RS12770	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DIJ64_RS12785	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DIJ64_RS12795	COG0860	N-Acetylmuramoyl-L-alanine amidase
DIJ64_RS12810	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DIJ64_RS12820	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DIJ64_RS12920	COG1819	glycosyl
DIJ64_RS12925	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DIJ64_RS12955	COG3321	synthase
DIJ64_RS12955	COG1028	Short-chain dehydrogenase reductase Sdr
DIJ64_RS12955	COG0604	alcohol dehydrogenase
DIJ64_RS12975	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
DIJ64_RS13030	COG5416	Lipopolysaccharide assembly protein A domain
DIJ64_RS13065	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DIJ64_RS13140	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DIJ64_RS13175	COG0626	cystathionine gamma-synthase activity
DIJ64_RS13180	COG1714	RDD family
DIJ64_RS13205	COG0183	Belongs to the thiolase family
DIJ64_RS13220	COG1024	Enoyl-CoA hydratase
DIJ64_RS13230	COG1575	Belongs to the MenA family. Type 1 subfamily
DIJ64_RS13250	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DIJ64_RS13260	COG0785	Cytochrome C biogenesis protein
DIJ64_RS13270	COG0406	alpha-ribazole phosphatase activity
DIJ64_RS13310	COG0113	porphobilinogen synthase activity
DIJ64_RS13320	COG0181	hydroxymethylbilane synthase activity
DIJ64_RS13325	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
DIJ64_RS13340	COG0560	Phosphoserine phosphatase
DIJ64_RS13345	COG2030	dehydratase
DIJ64_RS13350	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DIJ64_RS13355	COG0204	Acyl-transferase
DIJ64_RS13375	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DIJ64_RS13380	COG1082	Xylose isomerase domain protein TIM barrel
DIJ64_RS13390	COG0248	Ppx GppA phosphatase
DIJ64_RS13425	COG5002	protein histidine kinase activity
DIJ64_RS13560	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DIJ64_RS13610	COG0287	Prephenate dehydrogenase
DIJ64_RS13620	COG0590	tRNA wobble adenosine to inosine editing
DIJ64_RS13635	COG0393	Putative heavy-metal-binding
DIJ64_RS13640	COG0393	Putative heavy-metal-binding
DIJ64_RS13710	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DIJ64_RS13720	COG0542	response to heat
DIJ64_RS13735	COG0789	Transcriptional regulator
DIJ64_RS13740	COG0484	heat shock protein binding
DIJ64_RS13745	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DIJ64_RS13780	COG2181	nitrate reductase activity
DIJ64_RS13780	COG0247	lactate metabolic process
DIJ64_RS13910	COG1404	Belongs to the peptidase S8 family
DIJ64_RS13925	COG4842	Belongs to the WXG100 family
DIJ64_RS13955	COG0464	growth
DIJ64_RS14010	COG0318	PFAM AMP-dependent synthetase and ligase
DIJ64_RS14025	COG1984	allophanate hydrolase subunit 2
DIJ64_RS14090	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DIJ64_RS14105	COG1960	acyl-CoA dehydrogenase activity
DIJ64_RS14125	COG2030	dehydratase
DIJ64_RS14140	COG1472	Belongs to the glycosyl hydrolase 3 family
DIJ64_RS14150	COG4981	capsule polysaccharide biosynthetic process
DIJ64_RS14175	COG1012	belongs to the aldehyde dehydrogenase family
DIJ64_RS14245	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DIJ64_RS14250	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DIJ64_RS14275	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
DIJ64_RS14325	COG2267	carboxylic ester hydrolase activity
DIJ64_RS14355	COG0129	dihydroxy-acid dehydratase activity
DIJ64_RS14360	COG1937	Protein conserved in bacteria
DIJ64_RS14375	COG3590	peptidase
DIJ64_RS14395	COG2409	Drug exporters of the RND superfamily
DIJ64_RS14415	COG2409	Drug exporters of the RND superfamily
DIJ64_RS14450	COG2030	dehydratase
DIJ64_RS14480	COG0277	FAD linked oxidase domain protein
DIJ64_RS14525	COG1012	belongs to the aldehyde dehydrogenase family
DIJ64_RS14530	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
DIJ64_RS14590	COG0772	Belongs to the SEDS family
DIJ64_RS14615	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
DIJ64_RS14640	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DIJ64_RS14665	COG0583	DNA-binding transcription factor activity
DIJ64_RS14670	COG1376	ErfK ybiS ycfS ynhG family protein
DIJ64_RS14700	COG2755	lipolytic protein G-D-S-L family
DIJ64_RS14700	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DIJ64_RS14715	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DIJ64_RS14790	COG0305	Participates in initiation and elongation during chromosome replication
DIJ64_RS14805	COG0629	single-stranded DNA binding
DIJ64_RS14810	COG0360	Binds together with S18 to 16S ribosomal RNA
DIJ64_RS14825	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DIJ64_RS14880	COG0617	tRNA 3'-terminal CCA addition
DIJ64_RS14905	COG0492	ferredoxin-NADP+ reductase activity
DIJ64_RS14905	COG3118	belongs to the thioredoxin family
DIJ64_RS14910	COG3409	Peptidoglycan-binding domain 1 protein
DIJ64_RS14910	COG0860	N-Acetylmuramoyl-L-alanine amidase
DIJ64_RS14920	COG1475	DNA binding
DIJ64_RS14925	COG1192	Involved in chromosome partitioning
DIJ64_RS14940	COG0706	membrane insertase activity