locus-tag class description G6N15_RS00080 ENOG41082SX arsR family transcriptional regulator G6N15_RS00105 ENOG4105NQG DoxX G6N15_RS00110 ENOG4105VUN Transcriptional regulator G6N15_RS00150 ENOG4105DRS transport system, permease G6N15_RS00175 ENOG4105IDI abc transporter atp-binding protein G6N15_RS00220 ENOG4105H08 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) G6N15_RS00265 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) G6N15_RS00275 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) G6N15_RS00310 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) G6N15_RS00315 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) G6N15_RS00325 ENOG4107ZN8 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) G6N15_RS00330 ENOG4108KPJ rna polymerase sigma factor G6N15_RS00355 ENOG4105CEY Amp-dependent synthetase and ligase G6N15_RS00365 ENOG4107EEY synthase G6N15_RS00375 ENOG4105C0W non-ribosomal peptide synthetase G6N15_RS00380 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase G6N15_RS00405 ENOG4105F95 Monooxygenase G6N15_RS00480 ENOG4108IJ6 ABC transporter G6N15_RS00485 ENOG4105ECW sulfate abc transporter G6N15_RS00490 ENOG4108I5D sulfate abc transporter G6N15_RS00495 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein G6N15_RS00530 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) G6N15_RS00575 ENOG4105KQC Competence protein G6N15_RS00590 ENOG4105CC9 acyl-Coa dehydrogenase G6N15_RS00595 ENOG4105C1G acyl-Coa dehydrogenase G6N15_RS00635 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) G6N15_RS00650 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit G6N15_RS00655 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) G6N15_RS00660 ENOG41066YJ Beta-lactamase G6N15_RS00670 ENOG4105BZ1 (ABC) transporter G6N15_RS00695 ENOG4105BZU Histidine kinase G6N15_RS00700 ENOG4108RVA ribokinase G6N15_RS00720 ENOG4108DWA Nad synthetase G6N15_RS00750 ENOG4105K46 50S ribosomal protein l27 G6N15_RS00760 ENOG4105C03 ribonuclease G6N15_RS00775 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase G6N15_RS00795 ENOG4105EG6 Saccharopine dehydrogenase G6N15_RS00800 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein G6N15_RS00820 ENOG4105DQU oxidoreductase, subunit beta G6N15_RS00825 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein G6N15_RS00835 ENOG4107QK5 Homocysteine s-methyltransferase G6N15_RS00840 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) G6N15_RS00890 ENOG4105MC2 DSBA oxidoreductase G6N15_RS00935 ENOG4108IG5 Transcriptional regulator G6N15_RS00940 ENOG410905P Pyridoxamine 5-phosphate G6N15_RS00990 ENOG4105C7I Dehydrogenase G6N15_RS01000 ENOG4107YH6 single-stranded DNA-binding protein G6N15_RS01035 ENOG4105D7V transposase G6N15_RS01040 ENOG4105H08 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) G6N15_RS01050 ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 G6N15_RS01070 ENOG4105DJG MaoC domain protein dehydratase G6N15_RS01075 ENOG4105C1G acyl-Coa dehydrogenase G6N15_RS01085 ENOG4107QX3 carboxylase G6N15_RS01105 ENOG4105E1F short-chain dehydrogenase reductase G6N15_RS01110 ENOG4105D7A ATP-binding protein G6N15_RS01130 ENOG4107UBC ErfK ybiS ycfS ynhG family protein G6N15_RS01140 ENOG4107UWY Methyltransferase G6N15_RS01145 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) G6N15_RS01160 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) G6N15_RS01175 ENOG4108WKN secreted protein G6N15_RS01270 ENOG4105D2B acyl-CoA dehydrogenase G6N15_RS01275 ENOG4105D2B acyl-CoA dehydrogenase G6N15_RS01280 ENOG4105CC9 acyl-Coa dehydrogenase G6N15_RS01285 ENOG4105C1G acyl-Coa dehydrogenase G6N15_RS01290 ENOG4105CEY Amp-dependent synthetase and ligase G6N15_RS01310 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein G6N15_RS01320 ENOG4105CEY Amp-dependent synthetase and ligase G6N15_RS01335 ENOG4105CPP Dehydrogenase, E1 component G6N15_RS01340 ENOG4107RUY (E1 component), alpha subunit G6N15_RS01355 ENOG4105D2B acyl-CoA dehydrogenase G6N15_RS01360 ENOG4105D2B acyl-CoA dehydrogenase G6N15_RS01370 ENOG4106A3M Cytochrome p-450 G6N15_RS01395 ENOG4107QX3 carboxylase G6N15_RS01425 ENOG4106A3M Cytochrome p-450 G6N15_RS01440 ENOG4105X7H acyl-CoA dehydrogenase G6N15_RS01465 ENOG4108UKI Enoyl-CoA hydratase G6N15_RS01470 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) G6N15_RS01485 ENOG4105E39 Enoyl-CoA hydratase G6N15_RS01500 ENOG4105CGU Enoyl-CoA hydratase G6N15_RS01505 ENOG4106YT9 Enoyl-CoA hydratase G6N15_RS01520 ENOG4105CEY Amp-dependent synthetase and ligase G6N15_RS01525 ENOG4105CEY Amp-dependent synthetase and ligase G6N15_RS01530 ENOG4108WYP Transcriptional regulator G6N15_RS01535 ENOG4105C1G acyl-Coa dehydrogenase G6N15_RS01540 ENOG4105IYB L-carnitine dehydratase bile acid-inducible protein F G6N15_RS01545 ENOG4105CHU acetyl-coa acetyltransferase G6N15_RS01555 ENOG4105C1G acyl-Coa dehydrogenase G6N15_RS01560 ENOG41076PI Short-chain dehydrogenase reductase Sdr G6N15_RS01590 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation G6N15_RS01600 ENOG4105WX6 Membrane G6N15_RS01610 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) G6N15_RS01615 ENOG4108RQ5 Beta-lactamase domain-containing protein G6N15_RS01620 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) G6N15_RS01660 ENOG4107RKP Nicotinate phosphoribosyltransferase G6N15_RS01720 ENOG4108RU2 n-acetylmuramoyl-l-alanine amidase G6N15_RS01740 ENOG4105IDI abc transporter atp-binding protein G6N15_RS01790 ENOG4108IUN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) G6N15_RS01800 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) G6N15_RS01860 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) G6N15_RS01895 ENOG4108T62 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) G6N15_RS01915 ENOG4105YV6 ATP synthase i G6N15_RS01930 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) G6N15_RS01945 ENOG4105J5T Amp-dependent synthetase and ligase G6N15_RS01965 ENOG4105D6E homoserine dehydrogenase G6N15_RS01970 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) G6N15_RS01975 ENOG4105C75 arginyL-tRNA synthetase G6N15_RS01995 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) G6N15_RS02045 ENOG4108RM3 Phosphatase with a broad specificity. Its primary physiological function is to dephosphorylate 3'-phosphoadenosine 5'-phosphate (PAP) and 3'-phosphoadenosine 5'-phosphosulfate (PAPS). Thus, plays a role in mycobacterial sulfur metabolism, since it can serve as a key regulator of the sulfate assimilation pathway by controlling the pools of PAP and PAPS in the cell. To a lesser extent, is also able to hydrolyze inositol 1-phosphate (I- 1-P), fructose 1,6-bisphosphate (FBP) (to fructose 6-phosphate (F- 6-P)) and AMP in vitro, but this might has no significance in vivo G6N15_RS02090 ENOG4108IG5 Transcriptional regulator G6N15_RS02130 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) G6N15_RS02135 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) G6N15_RS02220 ENOG4105C87 Aminotransferase class I and II G6N15_RS02235 ENOG4105DEN Luciferase family G6N15_RS02250 ENOG4105CQB FAD linked oxidase domain protein G6N15_RS02305 ENOG4105K7K Transcriptional regulator G6N15_RS02315 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 G6N15_RS02340 ENOG4105D7N magnesium and cobalt transport protein CorA G6N15_RS02385 ENOG4105CJW magnesium transporter G6N15_RS02410 ENOG4105C0H protease G6N15_RS02415 ENOG4106684 G6N15_RS02430 ENOG4108X07 Tetr family transcriptional regulator G6N15_RS02435 ENOG4105CIG ABC transporter G6N15_RS02440 ENOG4105DIM ABC transporter G6N15_RS02455 ENOG4107QPH glycogen) synthase G6N15_RS02465 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) G6N15_RS02475 ENOG4105C3Q Glycosyl transferase, family 2 G6N15_RS02515 ENOG4105CEY Amp-dependent synthetase and ligase G6N15_RS02525 ENOG4105CEY Amp-dependent synthetase and ligase G6N15_RS02535 ENOG41062BK proline dehydrogenase G6N15_RS02540 ENOG4105C26 Dehydrogenase G6N15_RS02565 ENOG4105C0X amino acid G6N15_RS02570 ENOG4105C1G acyl-Coa dehydrogenase G6N15_RS02580 ENOG4108Z4U Ferredoxin G6N15_RS02605 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) G6N15_RS02635 ENOG4108IUE nitrate reductase beta subunit G6N15_RS02695 ENOG410905P Pyridoxamine 5-phosphate G6N15_RS02735 ENOG4108I9W Membrane G6N15_RS02750 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) G6N15_RS02765 ENOG4108JA1 polyketide synthase G6N15_RS02775 ENOG4107RCI amp-dependent synthetase and ligase G6N15_RS02795 ENOG410846T CoA-transferase family III G6N15_RS02800 ENOG4108UKI Enoyl-CoA hydratase G6N15_RS02810 ENOG4105CGD Nad-dependent epimerase dehydratase G6N15_RS02835 ENOG4105CHU acetyl-coa acetyltransferase G6N15_RS02880 ENOG4105CE1 Ferrous iron transport protein b G6N15_RS02895 ENOG4105KVH Transcriptional regulator G6N15_RS02905 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) G6N15_RS02945 ENOG4108Q5F Tetr family transcriptional regulator G6N15_RS02960 ENOG4108J5G 6-phosphogluconate dehydrogenase G6N15_RS03000 ENOG4105C3G gtp-binding protein G6N15_RS03025 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) G6N15_RS03055 ENOG4105CHR reductase G6N15_RS03080 ENOG4107T94 Endo-14-beta-xylanase G6N15_RS03085 ENOG4108IAB Phoh family G6N15_RS03100 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) G6N15_RS03110 ENOG4105CS9 pantothenic acid kinase G6N15_RS03140 ENOG4105X1P Steroid delta-isomerase G6N15_RS03145 ENOG4105C7Z Conserved Protein G6N15_RS03200 ENOG4105CHU acetyl-coa acetyltransferase G6N15_RS03210 ENOG4105E39 Enoyl-CoA hydratase G6N15_RS03255 ENOG4105CEY Amp-dependent synthetase and ligase G6N15_RS03305 ENOG4105C0X amino acid G6N15_RS03310 ENOG4105C0X amino acid G6N15_RS03340 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) G6N15_RS03345 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) G6N15_RS03400 ENOG4105DXN mazG family G6N15_RS03415 ENOG4108IG5 Transcriptional regulator G6N15_RS03435 ENOG4105K89 arsenate reductase G6N15_RS03455 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) G6N15_RS03460 ENOG4107RCI amp-dependent synthetase and ligase G6N15_RS03480 ENOG4105F8V Hydrolase, tatD family G6N15_RS03530 ENOG4107STQ Multicopper oxidase G6N15_RS03545 ENOG4108KPJ rna polymerase sigma factor G6N15_RS03550 ENOG4105CRQ synthase (Component I) G6N15_RS03590 ENOG410870F Cyclic nucleotide-binding protein G6N15_RS03595 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) G6N15_RS03670 ENOG4108C33 Resolvase G6N15_RS03770 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) G6N15_RS03795 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase G6N15_RS03800 ENOG41080UU 5-formyltetrahydrofolate cyclo-ligase G6N15_RS03815 ENOG41080FJ Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) G6N15_RS03820 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) G6N15_RS03855 ENOG4107QX3 carboxylase G6N15_RS03870 ENOG4105E39 Enoyl-CoA hydratase G6N15_RS03890 ENOG4105EET magnesium chelatase G6N15_RS03895 ENOG4105DC1 bifunctional purine biosynthesis protein purh G6N15_RS03930 ENOG4105CMV Succinyl-CoA synthetase subunit beta G6N15_RS03935 ENOG4105DR5 peptidase G6N15_RS03960 ENOG4107QP8 phosphohexose isomerase G6N15_RS03975 ENOG41082T9 Membrane G6N15_RS03985 ENOG4105BZ9 Cytochrome C oxidase, subunit I G6N15_RS04000 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) G6N15_RS04010 ENOG4105BZU Histidine kinase G6N15_RS04045 ENOG4105DEI Mannitol dehydrogenase G6N15_RS04055 ENOG4105DEI Mannitol dehydrogenase G6N15_RS04060 ENOG4105D7K pfkb domain protein G6N15_RS04080 ENOG4107MMM Anti-sigma-factor antagonist G6N15_RS04085 ENOG4105FUA antagonist G6N15_RS04090 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase G6N15_RS04200 ENOG4107MVR Transcriptional regulator G6N15_RS04250 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) G6N15_RS04275 ENOG4107R8H Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) G6N15_RS04315 ENOG4108N0W Major Facilitator superfamily G6N15_RS04325 ENOG4105CHF Glutathione S-transferase G6N15_RS04335 ENOG4105VEQ Cold shock protein G6N15_RS04345 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) G6N15_RS04365 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) G6N15_RS04385 ENOG4105CFI type iii restriction protein res subunit G6N15_RS04390 ENOG4105CHU acetyl-coa acetyltransferase G6N15_RS04400 ENOG4108M8W Monooxygenase G6N15_RS04415 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) G6N15_RS04420 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase G6N15_RS04425 ENOG4105CHU acetyl-coa acetyltransferase G6N15_RS04445 ENOG410846T CoA-transferase family III G6N15_RS04470 ENOG4105CEY Amp-dependent synthetase and ligase G6N15_RS04480 ENOG4105CEY Amp-dependent synthetase and ligase G6N15_RS04485 ENOG4105E39 Enoyl-CoA hydratase G6N15_RS04530 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) G6N15_RS04535 ENOG4108M8W Monooxygenase G6N15_RS04630 ENOG4105CY3 ABC transporter, permease G6N15_RS04645 ENOG4105CHR reductase G6N15_RS04670 ENOG4105CC9 acyl-Coa dehydrogenase G6N15_RS04680 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase G6N15_RS04715 ENOG4107EEP NADH dehydrogenase (quinone) (EC 1.6.99.5) G6N15_RS04735 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase G6N15_RS04745 ENOG4106A3M Cytochrome p-450 G6N15_RS04770 ENOG41084T3 4fe-4S ferredoxin iron-sulfur binding domain-containing protein G6N15_RS04795 ENOG4105CHU acetyl-coa acetyltransferase G6N15_RS04800 ENOG4105CGU Enoyl-CoA hydratase G6N15_RS04805 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G6N15_RS04810 ENOG4105CHR reductase G6N15_RS04830 ENOG4105DVW rieske (2Fe-2S) G6N15_RS04840 ENOG4105CPN adenine deaminase G6N15_RS04850 ENOG4105CC9 acyl-Coa dehydrogenase G6N15_RS04855 ENOG4105D2B acyl-CoA dehydrogenase G6N15_RS04860 ENOG4105CC9 acyl-Coa dehydrogenase G6N15_RS04875 ENOG41076PI Short-chain dehydrogenase reductase Sdr G6N15_RS04885 ENOG4105CHR reductase G6N15_RS04890 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G6N15_RS04930 ENOG4105CHR reductase G6N15_RS04935 ENOG4107QJG Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) G6N15_RS04975 ENOG4105CHR reductase G6N15_RS04985 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein G6N15_RS04990 ENOG4105MI0 Catalyzes the non-heme iron(II)-dependent oxidative cleavage of 2,3-dihydroxyphenylpropionic acid and 2,3- dihydroxicinnamic acid into 2-hydroxy-6-ketononadienedioate and 2- hydroxy-6-ketononatrienedioate, respectively (By similarity) G6N15_RS05000 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) G6N15_RS05010 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein G6N15_RS05020 ENOG4105CCU oxidase (Subunit III) G6N15_RS05045 ENOG4108R85 Short chain dehydrogenase G6N15_RS05050 ENOG4107XI7 Tetr family transcriptional regulator G6N15_RS05060 ENOG4105CHU acetyl-coa acetyltransferase G6N15_RS05075 ENOG4105CC9 acyl-Coa dehydrogenase G6N15_RS05080 ENOG4105D2B acyl-CoA dehydrogenase G6N15_RS05085 ENOG4105CEY Amp-dependent synthetase and ligase G6N15_RS05100 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G6N15_RS05130 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) G6N15_RS05175 ENOG41082SX arsR family transcriptional regulator G6N15_RS05210 ENOG4108KGH TRANSCRIPTIONal G6N15_RS05225 ENOG4105E2Z phosphate ABC transporter (Permease G6N15_RS05245 ENOG4107NHD transcriptional regulator G6N15_RS05270 ENOG4105PKJ carbohydrate binding G6N15_RS05285 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) G6N15_RS05295 ENOG4105CXB phosphoribosylaminoimidazole synthetase G6N15_RS05345 ENOG4105EZR dyp-type peroxidase family protein G6N15_RS05375 ENOG4107VGR Catalase G6N15_RS05405 ENOG410839H phosphoribosylformylglycinamidine synthase G6N15_RS05415 ENOG4107T8T UPF0173 metal-dependent hydrolase G6N15_RS05430 ENOG4108V06 Glutathione peroxidase G6N15_RS05435 ENOG4105C0R drug resistance transporter emrb qaca subfamily G6N15_RS05480 ENOG4105C83 adenylosuccinate lyase G6N15_RS05500 ENOG4105C1G acyl-Coa dehydrogenase G6N15_RS05510 ENOG4105CHU acetyl-coa acetyltransferase G6N15_RS05515 ENOG4105CFN oxalyl-CoA decarboxylase G6N15_RS05525 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) G6N15_RS05535 ENOG4106A3M Cytochrome p-450 G6N15_RS05600 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) G6N15_RS05625 ENOG4105BZU Histidine kinase G6N15_RS05630 ENOG4105CK6 Two component transcriptional regulator (Winged helix family G6N15_RS05655 ENOG4105N0U Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) G6N15_RS05695 ENOG4107TB5 TRANSCRIPTIONal G6N15_RS05710 ENOG4107S2E monooxygenase G6N15_RS05720 ENOG4105H37 Glyoxalase Bleomycin resistance protein (Dioxygenase G6N15_RS05735 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein G6N15_RS05750 ENOG4106KE4 Dehydrogenase G6N15_RS05770 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase G6N15_RS05800 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone G6N15_RS05820 ENOG4105CHR reductase G6N15_RS05830 ENOG4105X7H acyl-CoA dehydrogenase G6N15_RS05835 ENOG4108KC2 acyl-Coa dehydrogenase G6N15_RS05840 ENOG4105J5T Amp-dependent synthetase and ligase G6N15_RS05865 ENOG4105DVW rieske (2Fe-2S) G6N15_RS05895 ENOG4105DVW rieske (2Fe-2S) G6N15_RS05925 ENOG4106YT9 Enoyl-CoA hydratase G6N15_RS05930 ENOG4108QIU Dehydrogenase G6N15_RS05935 ENOG4105CMR udp-glucose 4-epimerase G6N15_RS05950 ENOG4105DYW oxidoreductase G6N15_RS05965 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) G6N15_RS05985 ENOG4105CIJ rieske 2fe-2S domain-containing protein G6N15_RS06000 ENOG4105CHR reductase G6N15_RS06015 ENOG4105DF3 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity) G6N15_RS06025 ENOG4105IKQ hydratase G6N15_RS06030 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein G6N15_RS06055 ENOG410900P UPF0336 protein G6N15_RS06060 ENOG4105X7H acyl-CoA dehydrogenase G6N15_RS06065 ENOG4108RK3 acyl-Coa dehydrogenase G6N15_RS06075 ENOG4105F2C Acetyl-CoA acetyltransferase G6N15_RS06095 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr G6N15_RS06100 ENOG4105H9W Short-chain dehydrogenase reductase Sdr G6N15_RS06105 ENOG4105E39 Enoyl-CoA hydratase G6N15_RS06120 ENOG4105EA8 2-Nitropropane dioxygenase G6N15_RS06125 ENOG4105F2C Acetyl-CoA acetyltransferase G6N15_RS06135 ENOG4105CHR reductase G6N15_RS06140 ENOG4105CC9 acyl-Coa dehydrogenase G6N15_RS06145 ENOG4105CEY Amp-dependent synthetase and ligase G6N15_RS06150 ENOG4105CC9 acyl-Coa dehydrogenase G6N15_RS06155 ENOG4105D2B acyl-CoA dehydrogenase G6N15_RS06160 ENOG4105D2B acyl-CoA dehydrogenase G6N15_RS06215 ENOG4105D2B acyl-CoA dehydrogenase G6N15_RS06220 ENOG4108SGK Tetr family transcriptional regulator G6N15_RS06235 ENOG4105E0A ABC, transporter G6N15_RS06240 ENOG4105CC5 ABC transporter G6N15_RS06275 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) G6N15_RS06280 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) G6N15_RS06285 ENOG4108VJ1 Transcriptional regulator (CarD family G6N15_RS06340 ENOG4105D9G High-affinity G6N15_RS06370 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) G6N15_RS06400 ENOG4105EEI dihydropteroate synthase G6N15_RS06410 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) G6N15_RS06415 ENOG4105D74 hydrolase G6N15_RS06425 ENOG4105CPQ Dehydrogenase G6N15_RS06440 ENOG4105C85 amino acid G6N15_RS06455 ENOG4108UGV hypoxanthine phosphoribosyltransferase G6N15_RS06485 ENOG4105DMF Dehydrogenase G6N15_RS06535 ENOG4107QRG dna polymerase iii G6N15_RS06565 ENOG4105VEQ Cold shock protein G6N15_RS06570 ENOG4108I5C dEAD DEAH box helicase G6N15_RS06710 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component G6N15_RS06715 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component G6N15_RS06725 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) G6N15_RS06750 ENOG4105P8F nudix hydrolase G6N15_RS06760 ENOG4105CSM endonuclease III G6N15_RS06775 ENOG410836F Transposase G6N15_RS06780 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) G6N15_RS06860 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) G6N15_RS06865 ENOG4108Z0Z intracellular protease Pfpi family G6N15_RS06880 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone G6N15_RS06900 ENOG4108WQ6 secreted protein G6N15_RS06905 ENOG4105C7R Atpase associated with various cellular activities aaa_3 G6N15_RS06940 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) G6N15_RS06960 ENOG4105C92 Aminotransferase class V G6N15_RS06975 ENOG4105E46 N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process G6N15_RS06995 ENOG4108ZHJ Organic hydroperoxide resistance protein G6N15_RS07015 ENOG4108NJC G6N15_RS07045 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) G6N15_RS07065 ENOG41085QW Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) G6N15_RS07070 ENOG4108RU2 n-acetylmuramoyl-l-alanine amidase G6N15_RS07085 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase G6N15_RS07095 ENOG4105XT2 Transcriptional regulator G6N15_RS07115 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) G6N15_RS07205 ENOG4106A3M Cytochrome p-450 G6N15_RS07220 ENOG4108UXE Protein tyrosine phosphatase G6N15_RS07280 ENOG4108J2P Alpha beta hydrolase fold G6N15_RS07310 ENOG4108Z6B deaminase G6N15_RS07320 ENOG4105EVN Prephenate dehydrogenase G6N15_RS07335 ENOG4105E90 ABC transporter G6N15_RS07350 ENOG41060H3 Protein of unknown function (DUF1049) G6N15_RS07360 ENOG4108RH7 phosphoglycerate mutase G6N15_RS07390 ENOG4105CHR reductase G6N15_RS07415 ENOG4105BZU Histidine kinase G6N15_RS07420 ENOG4105CK6 Two component transcriptional regulator (Winged helix family G6N15_RS07555 ENOG410839S Toxic component of a toxin-antitoxin (TA) module (By similarity) G6N15_RS07580 ENOG4105IQ5 FAD linked oxidase domain protein G6N15_RS07640 ENOG4105J1Z Arabinosyltransferase G6N15_RS07645 ENOG4105F9F transposase G6N15_RS07660 ENOG4105D8K carboxyl transferase G6N15_RS07690 ENOG4107ISF Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component the mycobacterial cell wall. Catalyzes the transfer of arabinofuranosyl (Araf) residues residue from the sugar donor beta-D-arabinofuranosyl-1-monophosphoryldecaprenol (DPA) to the arabinan domain to form terminal beta-(1- 2)-linked Araf residues, which marks the end point for AG arabinan biosynthesis before decoration with mycolic acids G6N15_RS07705 ENOG410602S Transferase G6N15_RS07725 ENOG410667J hydrolase G6N15_RS07755 ENOG4105EXC Acyl-transferase G6N15_RS07780 ENOG4107SET aldo keto reductase G6N15_RS07820 ENOG4105CEY Amp-dependent synthetase and ligase G6N15_RS07845 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) G6N15_RS07915 ENOG4108YRB methyltransferase G6N15_RS07960 ENOG4105WQT MbtH domain protein G6N15_RS07985 ENOG4107RCI amp-dependent synthetase and ligase G6N15_RS08055 ENOG4108KGH TRANSCRIPTIONal G6N15_RS08125 ENOG4105CT3 Monooxygenase G6N15_RS08135 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) G6N15_RS08150 ENOG4105DCG PHP domain protein G6N15_RS08175 ENOG4105CBC glutamate synthase G6N15_RS08195 ENOG4106F1P AAA ATPase, central domain protein G6N15_RS08270 ENOG4105EC2 ftsk spoIIIe G6N15_RS08330 ENOG4105C1G acyl-Coa dehydrogenase G6N15_RS08345 ENOG4105TV9 FHA Domain-Containing protein G6N15_RS08370 ENOG4107TPY serine threonine protein kinase G6N15_RS08415 ENOG4105C79 DNA protecting protein DprA G6N15_RS08420 ENOG4105MJ2 Competence protein G6N15_RS08450 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) G6N15_RS08460 ENOG4105K7N UPF0232 protein G6N15_RS08470 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) G6N15_RS08475 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) G6N15_RS08490 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) G6N15_RS08495 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins G6N15_RS08505 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) G6N15_RS08510 ENOG4107QJE Chromosome Partitioning Protein G6N15_RS08525 ENOG4108E1C hydrolase G6N15_RS08565 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate G6N15_RS08595 ENOG41064CH Probable lipoprotein LpqN G6N15_RS08605 ENOG4105EMU Dehydrogenase G6N15_RS08615 ENOG4105CDA abc transporter atp-binding protein G6N15_RS08620 ENOG4105DRP amino acid AbC transporter G6N15_RS08655 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) G6N15_RS08665 ENOG4105BZ4 penicillin-binding protein G6N15_RS08675 ENOG410829C Binds together with S18 to 16S ribosomal RNA (By similarity) G6N15_RS08700 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) G6N15_RS08720 ENOG4107EXU Short-chain dehydrogenase reductase Sdr G6N15_RS08725 ENOG4107GD3 Catalyzes the conversion of acetoacetate to acetone and carbon dioxide (By similarity) G6N15_RS08745 ENOG410900P UPF0336 protein G6N15_RS08760 ENOG4105DVW rieske (2Fe-2S) G6N15_RS08780 ENOG4108VHC Short-chain dehydrogenase reductase Sdr G6N15_RS08815 ENOG4108YRB methyltransferase G6N15_RS08835 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) G6N15_RS08840 ENOG4105CEY Amp-dependent synthetase and ligase G6N15_RS08850 ENOG4105E39 Enoyl-CoA hydratase G6N15_RS08870 ENOG4105CEY Amp-dependent synthetase and ligase G6N15_RS08885 ENOG4105H9W Short-chain dehydrogenase reductase Sdr G6N15_RS08895 ENOG4107R5W Monooxygenase G6N15_RS08900 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr G6N15_RS08905 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G6N15_RS08920 ENOG4105EXC Acyl-transferase G6N15_RS08935 ENOG4105FF0 ErfK YbiS YcfS YnhG G6N15_RS09010 ENOG4105CJ1 ABC, transporter G6N15_RS09060 ENOG4105EJ2 Transcriptional regulator G6N15_RS09120 ENOG4105C57 major facilitator superfamily G6N15_RS09160 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction G6N15_RS09165 ENOG4105EUB pirin domain protein G6N15_RS09185 ENOG4108UGJ Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) G6N15_RS09190 ENOG4105C26 Dehydrogenase G6N15_RS09195 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr G6N15_RS09205 ENOG4105M2Z protein tyrosine serine phosphatase G6N15_RS09210 ENOG4105C1G acyl-Coa dehydrogenase G6N15_RS09215 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) G6N15_RS09220 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) G6N15_RS09225 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) G6N15_RS09235 ENOG4108R86 Transcriptional regulator G6N15_RS09255 ENOG4105CQB FAD linked oxidase domain protein G6N15_RS09280 ENOG4105FBW Monooxygenase G6N15_RS09320 ENOG4108WYP Transcriptional regulator G6N15_RS09330 ENOG4105CY3 ABC transporter, permease G6N15_RS09375 ENOG4105W8D rdd domain containing protein G6N15_RS09400 ENOG4105C28 cystathionine G6N15_RS09450 ENOG4105E5G Alpha beta hydrolase fold G6N15_RS09495 ENOG4105VPX protein, conserved in bacteria G6N15_RS09505 ENOG4105S7A ErfK ybiS ycfS ynhG family protein G6N15_RS09510 ENOG4105C9K Endothelin-converting enzyme 1 G6N15_RS09525 ENOG4105K4P CoA-binding domain protein G6N15_RS09555 ENOG4107R13 MMPL domain protein G6N15_RS09580 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) G6N15_RS09585 ENOG4108Z4X TRANSCRIPTIONal G6N15_RS09590 ENOG4105CHR reductase G6N15_RS09595 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) G6N15_RS09600 ENOG4105CEY Amp-dependent synthetase and ligase G6N15_RS09605 ENOG4105E39 Enoyl-CoA hydratase G6N15_RS09625 ENOG4105C1G acyl-Coa dehydrogenase G6N15_RS09640 ENOG4108EQM faD-dependent pyridine nucleotide-disulfide oxidoreductase G6N15_RS09645 ENOG4106A3M Cytochrome p-450 G6N15_RS09675 ENOG4105CAQ asparagine synthetase G6N15_RS09680 ENOG4105C0I Conserved Protein G6N15_RS09700 ENOG4105CEY Amp-dependent synthetase and ligase G6N15_RS09710 ENOG4105E39 Enoyl-CoA hydratase G6N15_RS09715 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase G6N15_RS09730 ENOG4105CEY Amp-dependent synthetase and ligase G6N15_RS09780 ENOG4108I69 Glycosyl transferases group 1 G6N15_RS09805 ENOG4105CEY Amp-dependent synthetase and ligase G6N15_RS09820 ENOG4108CCU Ribonucleotide-diphosphate reductase subunit beta G6N15_RS09835 ENOG4105D7V transposase G6N15_RS09840 ENOG4105C7K acetolactate synthase G6N15_RS09845 ENOG4105C26 Dehydrogenase G6N15_RS09870 ENOG4105CH6 catalase G6N15_RS09880 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction G6N15_RS09905 ENOG41073B4 coagulation factor 5 8 type domain-containing protein G6N15_RS09930 ENOG4105CHR reductase G6N15_RS09935 ENOG4105CHU acetyl-coa acetyltransferase G6N15_RS09940 ENOG4105CSU acyl-Coa dehydrogenase G6N15_RS09955 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) G6N15_RS09970 ENOG4107QZF nitrite reductase NADPH large subunit G6N15_RS09975 ENOG4107QZF nitrite reductase NADPH large subunit G6N15_RS09990 ENOG4107QND Nitrite extrusion protein G6N15_RS10005 ENOG4107R7A Allophanate hydrolase subunit 2 G6N15_RS10010 ENOG4105P4J Allophanate hydrolase, subunit 1 G6N15_RS10035 ENOG4105D2B acyl-CoA dehydrogenase G6N15_RS10065 ENOG4105IIV Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) G6N15_RS10070 ENOG4105C26 Dehydrogenase G6N15_RS10085 ENOG4106F1P AAA ATPase, central domain protein G6N15_RS10130 ENOG41090GG peptidase S8 and S53, subtilisin, kexin, sedolisin G6N15_RS10185 ENOG4105E0M Sulfatase G6N15_RS10195 ENOG4105E7Q Cob(II)yrinic acid a,c-diamide reductase G6N15_RS10245 ENOG4105IDI abc transporter atp-binding protein G6N15_RS10325 ENOG4105BZU Histidine kinase G6N15_RS10350 ENOG4105F0K SARP family transcriptional regulator G6N15_RS10360 ENOG4105D5G Transposase G6N15_RS10365 ENOG41069FZ L,D-transpeptidase catalytic domain G6N15_RS10395 ENOG4105C6Y Udp-glucose 6-dehydrogenase G6N15_RS10430 ENOG4105DF6 Fe-S oxidoreductase G6N15_RS10435 ENOG4105CFG Acts as a chaperone (By similarity) G6N15_RS10525 ENOG4105CFG Acts as a chaperone (By similarity) G6N15_RS10530 ENOG4108093 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ G6N15_RS10535 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) G6N15_RS10540 ENOG4105KNI merR family transcriptional Regulator G6N15_RS10560 ENOG4105MHT Transcriptional regulator, ARSR family G6N15_RS10575 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit G6N15_RS10640 ENOG4107XZ0 Peptidase M50 G6N15_RS10680 ENOG4105MGE Rhodanese domain protein G6N15_RS10695 ENOG4105CEP NADH dehydrogenase G6N15_RS10705 ENOG4105EMU Dehydrogenase G6N15_RS10740 ENOG4105WEF catalase G6N15_RS10750 ENOG4105XTG Pfam:DUF156 G6N15_RS10780 ENOG4105C1G acyl-Coa dehydrogenase G6N15_RS10785 ENOG4105C1G acyl-Coa dehydrogenase G6N15_RS10790 ENOG4105CHR reductase G6N15_RS10825 ENOG4105C5X domain protein G6N15_RS10865 ENOG4105CT1 (ABC) transporter G6N15_RS10890 ENOG4105WHD thiamine biosynthesis protein ThiS G6N15_RS10925 ENOG4105IIU Aminopeptidase G6N15_RS10930 ENOG4105IIU Aminopeptidase G6N15_RS10955 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) G6N15_RS10965 ENOG4105F95 Monooxygenase G6N15_RS10970 ENOG4105KNI merR family transcriptional Regulator G6N15_RS11035 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) G6N15_RS11050 ENOG4105H08 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) G6N15_RS11150 ENOG4105C26 Dehydrogenase G6N15_RS11180 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) G6N15_RS11235 ENOG4105C0H protease G6N15_RS11265 ENOG4107UJ9 cyclopropane-fatty-acyl-phospholipid synthase G6N15_RS11275 ENOG4108NUI synthase G6N15_RS11295 ENOG4106BRA Membrane G6N15_RS11305 ENOG4105V9F hemagglutinin G6N15_RS11320 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) G6N15_RS11370 ENOG4108YZJ Pfam:DUF2596 G6N15_RS11390 ENOG4105CY3 ABC transporter, permease G6N15_RS11445 ENOG41063NU Membrane G6N15_RS11450 ENOG4105EY0 Xylose isomerase domain protein TIM barrel G6N15_RS11485 ENOG4108NUI synthase G6N15_RS11490 ENOG410900P UPF0336 protein G6N15_RS11495 ENOG4108RXW HAD-superfamily subfamily IB hydrolase G6N15_RS11510 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) G6N15_RS11515 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) G6N15_RS11540 ENOG4105EXC Acyl-transferase G6N15_RS11560 ENOG4105C85 amino acid G6N15_RS11580 ENOG4108RH7 phosphoglycerate mutase G6N15_RS11590 ENOG4107QIV Cytochrome c biogenesis protein G6N15_RS11600 ENOG4105CRE cytochrome C G6N15_RS11630 ENOG4107USC Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity) G6N15_RS11690 ENOG4105PDP Short chain dehydrogenase G6N15_RS11710 ENOG4105CEY Amp-dependent synthetase and ligase G6N15_RS11720 ENOG4107TCW O-succinylbenzoate synthase G6N15_RS11780 ENOG4105D0M Protease HtpX homolog G6N15_RS11805 ENOG4105CT3 Monooxygenase G6N15_RS11830 ENOG4105CMR udp-glucose 4-epimerase G6N15_RS11840 ENOG4108RU2 n-acetylmuramoyl-l-alanine amidase G6N15_RS11845 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate G6N15_RS11850 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) G6N15_RS11950 ENOG4105KAK Plasmid pRiA4b ORF-3 family protein G6N15_RS11955 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving G6N15_RS11970 ENOG4105CWX Alpha-1,2-mannosidase G6N15_RS12030 ENOG4105C0D helicase G6N15_RS12125 ENOG4107S1E Beta-lactamase G6N15_RS12170 ENOG4105EMU Dehydrogenase G6N15_RS12185 ENOG4105DSY exodeoxyribonuclease V, gamma G6N15_RS12205 ENOG4108DBC nitroreductase G6N15_RS12210 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) G6N15_RS12230 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) G6N15_RS12245 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) G6N15_RS12270 ENOG410900P UPF0336 protein G6N15_RS12275 ENOG4108F01 MaoC domain protein G6N15_RS12305 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) G6N15_RS12310 ENOG4105CHP RNA polymerase G6N15_RS12325 ENOG4108NUI synthase G6N15_RS12400 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) G6N15_RS12415 ENOG4105D5G Transposase G6N15_RS12440 ENOG4105CSU acyl-Coa dehydrogenase G6N15_RS12475 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) G6N15_RS12525 ENOG4105XDV G6N15_RS12605 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) G6N15_RS12635 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) G6N15_RS12645 ENOG4105E6M Sulphatase-modifying factor protein G6N15_RS12685 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) G6N15_RS12690 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) G6N15_RS12700 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) G6N15_RS12715 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) G6N15_RS12725 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) G6N15_RS12750 ENOG4105F9F transposase G6N15_RS12755 ENOG4105DTD Dehydrogenase G6N15_RS12760 ENOG4105CPQ Dehydrogenase G6N15_RS12770 ENOG4105W4W Transcriptional regulator G6N15_RS12780 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase G6N15_RS12785 ENOG4108M3J Dehydrogenase G6N15_RS12790 ENOG4105CMG Carbohydrate kinase G6N15_RS12800 ENOG4108XW1 Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) G6N15_RS12805 ENOG4106N8J Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) G6N15_RS12845 ENOG4105H3G oxidoreductase G6N15_RS12850 ENOG4105C7K acetolactate synthase G6N15_RS12865 ENOG4105CIH Imidazole acetol-phosphate transaminase G6N15_RS12900 ENOG4105C1G acyl-Coa dehydrogenase G6N15_RS12905 ENOG4105C26 Dehydrogenase G6N15_RS12920 ENOG410616I blue (type 1) copper domain protein G6N15_RS12935 ENOG41061H0 Monooxygenase G6N15_RS12945 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) G6N15_RS12950 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) G6N15_RS13045 ENOG41090GG peptidase S8 and S53, subtilisin, kexin, sedolisin G6N15_RS13055 ENOG4105EC2 ftsk spoIIIe G6N15_RS13105 ENOG4105DYW oxidoreductase G6N15_RS13130 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) G6N15_RS13140 ENOG4105CHR reductase G6N15_RS13165 ENOG4105CVK Glutamate decarboxylase G6N15_RS13175 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 G6N15_RS13190 ENOG41080E2 ribosomal-protein-alanine acetyltransferase G6N15_RS13205 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) G6N15_RS13230 ENOG41061TZ Short-chain dehydrogenase reductase Sdr G6N15_RS13240 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) G6N15_RS13260 ENOG4108VT4 G6N15_RS13270 ENOG4107QVP Dehydrogenase G6N15_RS13300 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) G6N15_RS13325 ENOG4105PDP Short chain dehydrogenase G6N15_RS13330 ENOG4105GCF PGAM G6N15_RS13345 ENOG4107R6D beta-lactam binding protein AmpH G6N15_RS13350 ENOG4105VNY Trehalose 6-phosphate phosphatase G6N15_RS13365 ENOG4105C0B DNA polymerase III (alpha subunit) G6N15_RS13375 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) G6N15_RS13380 ENOG4105BZU Histidine kinase G6N15_RS13385 ENOG4105GWZ Roadblock lc7 family protein G6N15_RS13400 ENOG4105IDI abc transporter atp-binding protein G6N15_RS13405 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase G6N15_RS13410 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) G6N15_RS13450 ENOG4105DNP FAD linked oxidase domain protein G6N15_RS13455 ENOG4105F9F transposase G6N15_RS13475 ENOG4108IQK o-acetylhomoserine G6N15_RS13480 ENOG4105E9K Isocitrate dehydrogenase G6N15_RS13500 ENOG4107H3J ribonuclease G6N15_RS13505 ENOG4105CE4 GlcNAc 6-P deacetylase G6N15_RS13510 ENOG4107QNK )-transporter G6N15_RS13515 ENOG4105DZ1 carboxypeptidase G6N15_RS13520 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) G6N15_RS13525 ENOG4108KPJ rna polymerase sigma factor G6N15_RS13555 ENOG4105E33 succinate dehydrogenase G6N15_RS13600 ENOG4108T5I Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) G6N15_RS13625 ENOG4105FBN Acid phosphatase G6N15_RS13630 ENOG4105FBN Acid phosphatase G6N15_RS13640 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain G6N15_RS13655 ENOG4107RM1 amidohydrolase G6N15_RS13685 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) G6N15_RS13710 ENOG4107QRT dEAD DEAH box helicase G6N15_RS13740 ENOG4105C54 Major Facilitator superfamily G6N15_RS13745 ENOG4105CH6 catalase G6N15_RS13755 ENOG4105C26 Dehydrogenase G6N15_RS13820 ENOG4108JIK carboxylase G6N15_RS13850 ENOG4105D8K carboxyl transferase G6N15_RS13855 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase G6N15_RS13875 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) G6N15_RS13885 ENOG410846T CoA-transferase family III G6N15_RS13930 ENOG4107TB5 TRANSCRIPTIONal G6N15_RS13975 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) G6N15_RS13990 ENOG4107QKV phosphomannomutase G6N15_RS14000 ENOG4105EIP mannose-6-phosphate isomerase G6N15_RS14015 ENOG4105CUB amino acid G6N15_RS14020 ENOG4105EEF Alkane 1-monooxygenase G6N15_RS14025 ENOG41084UD rubredoxin G6N15_RS14030 ENOG4105VCQ rubredoxin G6N15_RS14040 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) G6N15_RS14060 ENOG4105G3P Lipoprotein lpqB G6N15_RS14090 ENOG4108S7Q sigma 54 modulation protein ribosomal protein S30ea G6N15_RS14095 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving G6N15_RS14120 ENOG4105CSR polyphosphate kinase 2 G6N15_RS14140 ENOG4108RVA ribokinase G6N15_RS14145 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) G6N15_RS14150 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase G6N15_RS14155 ENOG4108RAV Conserved protein G6N15_RS14160 ENOG4105CHR reductase G6N15_RS14170 ENOG4105WMN AntiSigma factor G6N15_RS14180 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit G6N15_RS14195 ENOG4107TE5 Lipid kinase G6N15_RS14215 ENOG4108ZM9 phosphoglycerate mutase G6N15_RS14280 ENOG4108YIQ Alpha beta hydrolase G6N15_RS14295 ENOG4105KNI merR family transcriptional Regulator G6N15_RS14345 ENOG4105WBQ Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) G6N15_RS14365 ENOG41063PX domain protein G6N15_RS14395 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) G6N15_RS14410 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family G6N15_RS14460 ENOG4105C7R Atpase associated with various cellular activities aaa_3 G6N15_RS14490 ENOG4105CYX Short-chain dehydrogenase reductase Sdr G6N15_RS14495 ENOG4108RZE Tetr family transcriptional regulator G6N15_RS14515 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr G6N15_RS14520 ENOG4105D2B acyl-CoA dehydrogenase G6N15_RS14525 ENOG4105CC9 acyl-Coa dehydrogenase G6N15_RS14530 ENOG4105FAE von Willebrand factor, type A G6N15_RS14560 ENOG4106A3M Cytochrome p-450 G6N15_RS14565 ENOG4105E39 Enoyl-CoA hydratase G6N15_RS14590 ENOG4105DF2 NADH dehydrogenase subunit j G6N15_RS14605 ENOG4108IEH NADH dehydrogenase subunit g G6N15_RS14660 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) G6N15_RS14675 ENOG4105C1G acyl-Coa dehydrogenase G6N15_RS14685 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase G6N15_RS14690 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G6N15_RS14720 ENOG4107S5I aldo keto reductase G6N15_RS14745 ENOG41076PI Short-chain dehydrogenase reductase Sdr G6N15_RS14805 ENOG4105C1G acyl-Coa dehydrogenase G6N15_RS14810 ENOG4105C1G acyl-Coa dehydrogenase G6N15_RS14820 ENOG4107TK4 histidinol-phosphate phosphatase G6N15_RS14855 ENOG4105CAK Cell division ATP-binding protein ftsE G6N15_RS14900 ENOG4108UKI Enoyl-CoA hydratase G6N15_RS14910 ENOG4105D9P serine threonine protein kinase G6N15_RS14920 ENOG4105CI0 Citrate lyase G6N15_RS14945 ENOG4105CNG UPF0061 protein G6N15_RS14960 ENOG4105CEY Amp-dependent synthetase and ligase G6N15_RS15045 ENOG4105DJ4 phosphatidylserine decarboxylase G6N15_RS15060 ENOG4108JQ1 Dehydrogenase G6N15_RS15070 ENOG4105D22 carbon starvation protein G6N15_RS15085 ENOG4105D2B acyl-CoA dehydrogenase G6N15_RS15100 ENOG41082MF Hydrogenase assembly chaperone hypC hupF G6N15_RS15110 ENOG4107RSS Hydrogenase accessory protein HypB G6N15_RS15115 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) G6N15_RS15175 ENOG4105EJ2 Transcriptional regulator G6N15_RS15180 ENOG4107RN6 Monooxygenase G6N15_RS15205 ENOG4105BZ9 Cytochrome C oxidase, subunit I G6N15_RS15215 ENOG4105DKW ABC transporter G6N15_RS15230 ENOG4107QVI Methyltransferase, type 11 G6N15_RS15245 ENOG4108V0V Pyrrolo-quinoline quinone G6N15_RS15250 ENOG4105EVB acetyltransferase G6N15_RS15285 ENOG4105CVP deoxyribo-dipyrimidine photolyase G6N15_RS15300 ENOG4105CVN desaturase G6N15_RS15305 ENOG4107SWE Methyltransferase G6N15_RS15360 ENOG4105C10 Electron transfer flavoprotein G6N15_RS15405 ENOG4105CTQ phosphohexokinase G6N15_RS15420 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) G6N15_RS15445 ENOG4105DPX Hydrogenase, large subunit G6N15_RS15480 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) G6N15_RS15490 ENOG4105WRB Hydrogenase assembly chaperone hypC hupF G6N15_RS15495 ENOG4105CQS hydrogenase expression formation protein HypD G6N15_RS15515 ENOG4108VGI doxx family G6N15_RS15545 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) G6N15_RS15565 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase G6N15_RS15570 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) G6N15_RS15595 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) G6N15_RS15615 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) G6N15_RS15625 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase G6N15_RS15630 ENOG4105CPF Cell wall formation (By similarity) G6N15_RS15650 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) G6N15_RS15660 ENOG4105DP4 dak2 domain fusion protein ylov G6N15_RS15680 ENOG4105CV8 reductase G6N15_RS15700 ENOG4106H78 methyltransferase G6N15_RS15710 ENOG4108M4U conserved membrane protein G6N15_RS15725 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) G6N15_RS15735 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) G6N15_RS15765 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) G6N15_RS15785 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY G6N15_RS15810 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) G6N15_RS15820 ENOG4105DZ1 carboxypeptidase G6N15_RS15830 ENOG410836F Transposase G6N15_RS15845 ENOG4107XUM An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) G6N15_RS15875 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) G6N15_RS15920 ENOG4105DMF Dehydrogenase G6N15_RS15925 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) G6N15_RS15935 ENOG4105CE9 30S ribosomal protein S2 G6N15_RS15945 ENOG4105DV0 amidase (EC 3.5.1.4 G6N15_RS15955 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) G6N15_RS15990 ENOG4105CYX Short-chain dehydrogenase reductase Sdr G6N15_RS16020 ENOG4108UDB Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) G6N15_RS16030 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) G6N15_RS16040 ENOG4105C1B dTDP-glucose 4-6-dehydratase G6N15_RS16050 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase G6N15_RS16055 ENOG4105DKP glycosyl transferase, family 9 G6N15_RS16060 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) G6N15_RS16065 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) G6N15_RS16080 ENOG4105C6Y Udp-glucose 6-dehydrogenase G6N15_RS16085 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) G6N15_RS16090 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) G6N15_RS16095 ENOG4105KNE Phosphatidate cytidylyltransferase G6N15_RS16100 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs G6N15_RS16120 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) G6N15_RS16155 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) G6N15_RS16165 ENOG4108Z86 Glutamine amidotransferase G6N15_RS16180 ENOG4105D9G High-affinity G6N15_RS16190 ENOG4105G5W regulator Fur family G6N15_RS16220 ENOG4106D5S Corrinoid adenosyltransferase BtuR CobO CobP G6N15_RS16230 ENOG4105E4E Thioester reductase domain-containing protein G6N15_RS16235 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) G6N15_RS16285 ENOG4105SFS phosphoesterase RecJ domain protein G6N15_RS16335 ENOG4107R13 MMPL domain protein G6N15_RS16420 ENOG4105NTK Transcriptional repressor Mpra G6N15_RS16435 ENOG4105NTK Transcriptional repressor Mpra G6N15_RS16445 ENOG4105E39 Enoyl-CoA hydratase G6N15_RS16455 ENOG41060JE PilT protein domain protein G6N15_RS16490 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) G6N15_RS16520 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) G6N15_RS16530 ENOG4107QWG 2-Nitropropane dioxygenase G6N15_RS16535 ENOG4105DCF alanine dehydrogenase G6N15_RS16580 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) G6N15_RS16595 ENOG4108JIK carboxylase G6N15_RS16605 ENOG4105CHR reductase G6N15_RS16615 ENOG4105D2B acyl-CoA dehydrogenase G6N15_RS16620 ENOG4105D2B acyl-CoA dehydrogenase G6N15_RS16625 ENOG4107SET aldo keto reductase G6N15_RS16655 ENOG4105T0Z Conserved Protein G6N15_RS16680 ENOG4105CK6 Two component transcriptional regulator (Winged helix family G6N15_RS16685 ENOG4105EB3 Histidine kinase G6N15_RS16690 ENOG4105CVN desaturase G6N15_RS16715 ENOG4105EAH synthase G6N15_RS16725 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) G6N15_RS16770 ENOG4107RCI amp-dependent synthetase and ligase G6N15_RS16820 ENOG4105MXB limonene-12-epoxide hydrolase G6N15_RS16845 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) G6N15_RS16855 ENOG4105C99 atpase involved in dna repair G6N15_RS16860 ENOG4105PP6 Membrane G6N15_RS16870 ENOG4105PP6 Membrane G6N15_RS16880 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) G6N15_RS16890 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) G6N15_RS16900 ENOG4105C1G acyl-Coa dehydrogenase G6N15_RS16910 ENOG4107YB1 Trehalose corynomycolyl transferase G6N15_RS16930 ENOG4108X6U May play a role in the intracellular transport of hydrophobic ligands G6N15_RS17090 ENOG4107VEG TrkA-N domain protein G6N15_RS17095 ENOG4105C0X amino acid G6N15_RS17155 ENOG4105C1Q protoporphyrinogen oxidase G6N15_RS17165 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) G6N15_RS17170 ENOG4105E0X reductase G6N15_RS17185 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) G6N15_RS17205 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) G6N15_RS17210 ENOG4105K6V RNA polymerase G6N15_RS17345 ENOG4105CXK mandelate racemase muconate lactonizing G6N15_RS17360 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) G6N15_RS17380 ENOG4107UBC ErfK ybiS ycfS ynhG family protein G6N15_RS17395 ENOG4108UN4 phage SPO1 DNA polymerase-related protein G6N15_RS17405 ENOG4105CQB FAD linked oxidase domain protein G6N15_RS17415 ENOG4107JEE Short-chain dehydrogenase reductase Sdr G6N15_RS17420 ENOG4105MHT Transcriptional regulator, ARSR family G6N15_RS17460 ENOG4105FB2 class II Aldolase G6N15_RS17465 ENOG4108QJ2 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase G6N15_RS17480 ENOG4105FUY alpha subunit G6N15_RS17510 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase G6N15_RS17525 ENOG4107QNJ CoA-transferase subunit B G6N15_RS17590 ENOG4107SHJ sulfite reductase subunit b G6N15_RS17665 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic G6N15_RS17675 ENOG4105XTG Pfam:DUF156 G6N15_RS17690 ENOG4105MC2 DSBA oxidoreductase G6N15_RS17850 ENOG4107S5I aldo keto reductase G6N15_RS17880 ENOG4105E2K Glycosyl transferase (Group 1 G6N15_RS17885 ENOG4108Z4K mutator MutT protein G6N15_RS17895 ENOG4105C29 acyl-CoA thioesterase G6N15_RS17915 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) G6N15_RS17930 ENOG4105E4E Thioester reductase domain-containing protein G6N15_RS17945 ENOG4108TVJ Nitroreductase G6N15_RS17965 ENOG4107RTU Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) G6N15_RS17970 ENOG4108NY6 Extracellular solute-binding protein, family 5 G6N15_RS17980 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) G6N15_RS18015 ENOG4107W7X Aldolase G6N15_RS18020 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) G6N15_RS18130 ENOG4107ZED Uncharacterised protein family UPF0047 G6N15_RS18145 ENOG4105HHA aminodeoxychorismate lyase G6N15_RS18150 ENOG4105E2X shikimate dehydrogenase G6N15_RS18190 ENOG4105DC7 peptidase M24 G6N15_RS18210 ENOG4105CXN decarboxylase G6N15_RS18245 ENOG4105CXT aspartate transcarbamylase G6N15_RS18260 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain G6N15_RS18270 ENOG4105SKN orotidine 5''-phosphate decarboxylase G6N15_RS18275 ENOG4105X1Q TOBE domain protein G6N15_RS18280 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase G6N15_RS18290 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) G6N15_RS18305 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP G6N15_RS18310 ENOG4107RN6 Monooxygenase G6N15_RS18350 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) G6N15_RS18415 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) G6N15_RS18450 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase G6N15_RS18455 ENOG4105BZA Phosphoglycerate kinase G6N15_RS18505 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) G6N15_RS18530 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein G6N15_RS18555 ENOG4107JC6 Membrane G6N15_RS18575 ENOG4105C3K feS assembly ATPase SufC G6N15_RS18585 ENOG4108UNV SUF system FeS assembly protein, NifU family G6N15_RS18605 ENOG4106PVI ATP-dependent carboxylate-amine ligase (By similarity) G6N15_RS18640 ENOG41066UM arsR family transcriptional regulator G6N15_RS18645 ENOG41080RH Thioredoxin G6N15_RS18655 ENOG4105C5H ABC transporter G6N15_RS18665 ENOG4108Q5F Tetr family transcriptional regulator G6N15_RS18670 ENOG4107QM5 aconitate hydratase G6N15_RS18680 ENOG4105ZXU NLP P60 protein G6N15_RS18690 ENOG4105C7R Atpase associated with various cellular activities aaa_3 G6N15_RS18700 ENOG4107QVM von Willebrand factor, type A G6N15_RS18750 ENOG4108RQS Two component transcriptional regulator (Winged helix family G6N15_RS18755 ENOG4106F60 Histidine kinase G6N15_RS18815 ENOG4108IG5 Transcriptional regulator G6N15_RS18840 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) G6N15_RS18850 ENOG41089UC methyltransferase, type 11 G6N15_RS18860 ENOG4107RCI amp-dependent synthetase and ligase G6N15_RS18895 ENOG4105HDK L-asparaginase G6N15_RS18925 ENOG4108W6C Dehydrogenase G6N15_RS18930 ENOG41084HI prevent-host-death family G6N15_RS18935 ENOG4105KRQ Addiction module toxin, Txe YoeB family G6N15_RS19005 ENOG4107QNE Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) G6N15_RS19010 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) G6N15_RS19050 ENOG41066NP positive regulation by symbiont of host immune response G6N15_RS19075 ENOG4107S3R L-aspartate oxidase G6N15_RS19115 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase G6N15_RS19120 ENOG4108MWI inositol mono-phosphatase G6N15_RS19130 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase G6N15_RS19135 ENOG4105DQQ Major facilitator superfamily MFS_1 G6N15_RS19140 ENOG4108Z4U Ferredoxin G6N15_RS19145 ENOG4105EQH reductase G6N15_RS19165 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) G6N15_RS19215 ENOG4105C29 acyl-CoA thioesterase G6N15_RS19235 ENOG4108JJ9 ABC, transporter G6N15_RS19240 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii G6N15_RS19245 ENOG4105C4M (Ubiquinol oxidase) subunit I G6N15_RS19310 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) G6N15_RS19320 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) G6N15_RS19325 ENOG4105DQE DNA ligase G6N15_RS19330 ENOG4105DQE DNA ligase G6N15_RS19340 ENOG4105IDI abc transporter atp-binding protein G6N15_RS19370 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) G6N15_RS19375 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB G6N15_RS19425 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) G6N15_RS19450 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) G6N15_RS19455 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) G6N15_RS19465 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) G6N15_RS19500 ENOG4105C5H ABC transporter G6N15_RS19510 ENOG4105W49 UPF0434 protein G6N15_RS19525 ENOG4105CJ1 ABC, transporter G6N15_RS19530 ENOG4108VX5 3-methyladenine DNA glycosylase G6N15_RS19560 ENOG4105DSU hydrolase G6N15_RS19620 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) G6N15_RS19635 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) G6N15_RS19675 ENOG4108Q50 Histidine kinase G6N15_RS19695 ENOG4105CUB amino acid G6N15_RS19700 ENOG4108MJN Glycosyl Transferase G6N15_RS19735 ENOG4105CXN decarboxylase G6N15_RS19745 ENOG4108RZE Tetr family transcriptional regulator G6N15_RS19800 ENOG4107EMZ glycosyl transferase family G6N15_RS19820 ENOG4107QND Nitrite extrusion protein G6N15_RS19980 ENOG4105CJW magnesium transporter G6N15_RS19985 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) G6N15_RS19995 ENOG4105C0X amino acid G6N15_RS20015 ENOG4105J1P transposase, IS3 IS911 family protein G6N15_RS20075 ENOG4107QND Nitrite extrusion protein G6N15_RS20105 ENOG41084T3 4fe-4S ferredoxin iron-sulfur binding domain-containing protein G6N15_RS20135 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein G6N15_RS20230 ENOG4107UAX integral membrane protein G6N15_RS20235 ENOG4105C37 (CBS) domain G6N15_RS20245 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) G6N15_RS20270 ENOG4105CEP NADH dehydrogenase G6N15_RS20275 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone G6N15_RS20370 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) G6N15_RS20410 ENOG4108X7C Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) G6N15_RS20420 ENOG4105C5Q Transcriptional regulator G6N15_RS20435 ENOG4108UKI Enoyl-CoA hydratase G6N15_RS20500 ENOG4105CHR reductase G6N15_RS20545 ENOG4107RCI amp-dependent synthetase and ligase G6N15_RS20555 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone G6N15_RS20590 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) G6N15_RS20610 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone G6N15_RS20670 ENOG4107RGD Major Facilitator superfamily G6N15_RS20695 ENOG4105E39 Enoyl-CoA hydratase G6N15_RS20775 ENOG4105CEY Amp-dependent synthetase and ligase G6N15_RS20785 ENOG4106A3M Cytochrome p-450 G6N15_RS20800 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) G6N15_RS20835 ENOG4105C26 Dehydrogenase G6N15_RS20850 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein G6N15_RS20880 ENOG4105MWK D-amino acid dehydrogenase, small subunit G6N15_RS20885 ENOG4105ETU transcriptional activator (TenA G6N15_RS20900 ENOG4105CSR polyphosphate kinase 2 G6N15_RS21050 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) G6N15_RS21105 ENOG4106FRU abrb family transcriptional regulator G6N15_RS21125 ENOG4105DGU Histone deacetylase G6N15_RS21135 ENOG4108Z7R Chaperone CsaA G6N15_RS21170 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component G6N15_RS21175 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component G6N15_RS21185 ENOG4108KPJ rna polymerase sigma factor G6N15_RS21195 ENOG4108RWI nicotinamidase G6N15_RS21205 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) G6N15_RS21245 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family G6N15_RS21255 ENOG4105EBR Carboxylesterase G6N15_RS21270 ENOG4108JA1 polyketide synthase G6N15_RS21295 ENOG4105CPN adenine deaminase G6N15_RS21315 ENOG4105CTK cobaltochelatase, cobn subunit G6N15_RS21330 ENOG4106YVY Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) (By similarity) G6N15_RS21335 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) G6N15_RS21340 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) G6N15_RS21390 ENOG4108RG3 short-chain dehydrogenase reductase G6N15_RS21445 ENOG4107TMB Transcriptional regulator G6N15_RS21480 ENOG4105KPK Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) G6N15_RS21525 ENOG4105C0H protease G6N15_RS21555 ENOG4105C3R Methionine synthase G6N15_RS21565 ENOG4105EMU Dehydrogenase G6N15_RS21620 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) G6N15_RS21670 ENOG4105DFA alanine racemase domain protein G6N15_RS21680 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) G6N15_RS21695 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) G6N15_RS21750 ENOG4105CJN penicillin-binding protein G6N15_RS21780 ENOG4105R14 (LipO)protein G6N15_RS21795 ENOG41090CE integral membrane protein G6N15_RS21800 ENOG4105KYH transcriptional regulatory protein G6N15_RS21810 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase G6N15_RS21830 ENOG4105E9Q Acyl-transferase G6N15_RS21840 ENOG4105D0U Arsenite-activated ATPase (ArsA) G6N15_RS21890 ENOG4105CCU oxidase (Subunit III) G6N15_RS21935 ENOG4108ZRS Part of cytochrome c oxidase, its function is G6N15_RS21950 ENOG4107T4Z adenosine kinase G6N15_RS22025 ENOG4107R13 MMPL domain protein G6N15_RS22100 ENOG4108VGI doxx family G6N15_RS22110 ENOG4107U9T Pfam:Ribonuclease_BN G6N15_RS22115 ENOG4108SVW integral membrane protein G6N15_RS22120 ENOG4105DHT Metal Dependent Phosphohydrolase G6N15_RS22170 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) G6N15_RS22215 ENOG4105C26 Dehydrogenase G6N15_RS22250 ENOG41086VY Fic/DOC family G6N15_RS22310 ENOG4105CIR epoxide hydrolase G6N15_RS22375 ENOG410836F Transposase G6N15_RS22380 ENOG4107EXU Short-chain dehydrogenase reductase Sdr G6N15_RS22385 ENOG4107RSM transcriptional regulator G6N15_RS22395 ENOG4105DVA methyltransferase G6N15_RS22455 ENOG4105PDP Short chain dehydrogenase G6N15_RS22535 ENOG4108IPT Naphthoate synthase G6N15_RS22545 ENOG4105CHR reductase G6N15_RS22560 ENOG4105EMU Dehydrogenase G6N15_RS22630 ENOG4105CEY Amp-dependent synthetase and ligase