locus-tag class description G6N00_RS00055 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) G6N00_RS00110 ENOG4107VMB Beta-lactamase domain protein G6N00_RS00125 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) G6N00_RS00130 ENOG4108NY6 Extracellular solute-binding protein, family 5 G6N00_RS00135 ENOG4107RTU Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) G6N00_RS00160 ENOG4105E4E Thioester reductase domain-containing protein G6N00_RS00210 ENOG4105P3N Membrane G6N00_RS00220 ENOG4105CDY transcriptional regulatory protein G6N00_RS00235 ENOG4105C29 acyl-CoA thioesterase G6N00_RS00245 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) G6N00_RS00285 ENOG4107S5I aldo keto reductase G6N00_RS00290 ENOG4105PMW Domain of unknown function (DUF1990) G6N00_RS00345 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase G6N00_RS00385 ENOG4108QJ2 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase G6N00_RS00395 ENOG4107HP6 Transcriptional regulator G6N00_RS00415 ENOG4106PVI ATP-dependent carboxylate-amine ligase (By similarity) G6N00_RS00425 ENOG4107VGR Catalase G6N00_RS00430 ENOG4105CHR reductase G6N00_RS00450 ENOG4105E39 Enoyl-CoA hydratase G6N00_RS00535 ENOG4105MPZ Pfam:DUF1023 G6N00_RS00560 ENOG4107GD3 Catalyzes the conversion of acetoacetate to acetone and carbon dioxide (By similarity) G6N00_RS00595 ENOG4105MKU Transcriptional regulator G6N00_RS00615 ENOG4105C26 Dehydrogenase G6N00_RS00675 ENOG4105E0X reductase G6N00_RS00680 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) G6N00_RS00685 ENOG4107JTW chlorite dismutase G6N00_RS00725 ENOG4107R3E Citrate transporter G6N00_RS00730 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) G6N00_RS00735 ENOG4105C0X amino acid G6N00_RS00740 ENOG4107VEG TrkA-N domain protein G6N00_RS00905 ENOG4105C1G acyl-Coa dehydrogenase G6N00_RS00910 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) G6N00_RS00920 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) G6N00_RS00935 ENOG4105C99 atpase involved in dna repair G6N00_RS00945 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) G6N00_RS00985 ENOG4105MXB limonene-12-epoxide hydrolase G6N00_RS01045 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) G6N00_RS01055 ENOG4105T0Z Conserved Protein G6N00_RS01080 ENOG4105D2B acyl-CoA dehydrogenase G6N00_RS01085 ENOG4105D2B acyl-CoA dehydrogenase G6N00_RS01090 ENOG4105CHR reductase G6N00_RS01100 ENOG4108JIK carboxylase G6N00_RS01105 ENOG4105CEY Amp-dependent synthetase and ligase G6N00_RS01125 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) G6N00_RS01175 ENOG4105DCF alanine dehydrogenase G6N00_RS01180 ENOG4107QWG 2-Nitropropane dioxygenase G6N00_RS01190 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) G6N00_RS01220 ENOG4105C1G acyl-Coa dehydrogenase G6N00_RS01230 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) G6N00_RS01275 ENOG4107QI1 Mate efflux family protein G6N00_RS01280 ENOG4105SFS phosphoesterase RecJ domain protein G6N00_RS01290 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) G6N00_RS01330 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) G6N00_RS01370 ENOG4105D9G High-affinity G6N00_RS01400 ENOG4105H9W Short-chain dehydrogenase reductase Sdr G6N00_RS01410 ENOG4108Z86 Glutamine amidotransferase G6N00_RS01425 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) G6N00_RS01450 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) G6N00_RS01455 ENOG4105DZP Membrane-associated zinc metalloprotease G6N00_RS01460 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) G6N00_RS01480 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs G6N00_RS01485 ENOG4105KNE Phosphatidate cytidylyltransferase G6N00_RS01505 ENOG4107NHD transcriptional regulator G6N00_RS01520 ENOG4105CYX Short-chain dehydrogenase reductase Sdr G6N00_RS01540 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) G6N00_RS01565 ENOG4105DV0 amidase (EC 3.5.1.4 G6N00_RS01595 ENOG4105DMF Dehydrogenase G6N00_RS01620 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) G6N00_RS01630 ENOG4105CMR udp-glucose 4-epimerase G6N00_RS01645 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) G6N00_RS01665 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) G6N00_RS01690 ENOG4105DZ1 carboxypeptidase G6N00_RS01735 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) G6N00_RS01755 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) G6N00_RS01770 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) G6N00_RS01780 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) G6N00_RS01795 ENOG4108M4U conserved membrane protein G6N00_RS01800 ENOG4105C7K acetolactate synthase G6N00_RS01815 ENOG4106H78 methyltransferase G6N00_RS01850 ENOG4105DP4 dak2 domain fusion protein ylov G6N00_RS01915 ENOG4105CPF Cell wall formation (By similarity) G6N00_RS01920 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase G6N00_RS01930 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) G6N00_RS01975 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) G6N00_RS01980 ENOG4105ERH Fumarylacetoacetate hydrolase G6N00_RS01985 ENOG4105E5T Major Facilitator Superfamily G6N00_RS01990 ENOG4105E5T Major Facilitator Superfamily G6N00_RS01995 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) G6N00_RS02010 ENOG4105CS1 NAD(P)H quinone oxidoreductase G6N00_RS02025 ENOG4105C7K acetolactate synthase G6N00_RS02060 ENOG4105CTQ phosphohexokinase G6N00_RS02105 ENOG4105C28 cystathionine G6N00_RS02155 ENOG4105C10 Electron transfer flavoprotein G6N00_RS02230 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) G6N00_RS02235 ENOG4105CVN desaturase G6N00_RS02275 ENOG41087PP glycosyltransferase MGT family G6N00_RS02285 ENOG4105EYF MMPL domain protein G6N00_RS02305 ENOG4105EVB acetyltransferase G6N00_RS02310 ENOG4108V0V Pyrrolo-quinoline quinone G6N00_RS02335 ENOG4105UPE Enoyl-CoA hydratase G6N00_RS02345 ENOG4105DKW ABC transporter G6N00_RS02355 ENOG4105BZ9 Cytochrome C oxidase, subunit I G6N00_RS02390 ENOG4108X07 Tetr family transcriptional regulator G6N00_RS02400 ENOG4105F95 Monooxygenase G6N00_RS02405 ENOG4105EJ2 Transcriptional regulator G6N00_RS02480 ENOG4107YCY Transcriptional regulator G6N00_RS02495 ENOG4105D2B acyl-CoA dehydrogenase G6N00_RS02505 ENOG4107QIM DNA ligase G6N00_RS02510 ENOG4105CFG Acts as a chaperone (By similarity) G6N00_RS02520 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone G6N00_RS02525 ENOG4105CHU acetyl-coa acetyltransferase G6N00_RS02535 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G6N00_RS02575 ENOG410814C multidrug resistance protein G6N00_RS02625 ENOG4105DVW rieske (2Fe-2S) G6N00_RS02655 ENOG4105DVW rieske (2Fe-2S) G6N00_RS02670 ENOG4107RCI amp-dependent synthetase and ligase G6N00_RS02685 ENOG41086VY Fic/DOC family G6N00_RS02705 ENOG41080V3 Major Facilitator superfamily G6N00_RS02740 ENOG4105CI0 Citrate lyase G6N00_RS02755 ENOG4105CNG UPF0061 protein G6N00_RS02790 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) G6N00_RS02850 ENOG4105DVW rieske (2Fe-2S) G6N00_RS02855 ENOG4105EXG Transcriptional regulator G6N00_RS02860 ENOG4105IDI abc transporter atp-binding protein G6N00_RS02870 ENOG4105EXC Acyl-transferase G6N00_RS02900 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein G6N00_RS02910 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) G6N00_RS02915 ENOG4108Q5F Tetr family transcriptional regulator G6N00_RS02935 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) G6N00_RS02940 ENOG4107RYD Part of the ABC transporter FtsEX involved in cellular division (By similarity) G6N00_RS02945 ENOG4105CAK Cell division ATP-binding protein ftsE G6N00_RS02955 ENOG4105D8X mechanosensitive ion channel G6N00_RS02965 ENOG4105EQH reductase G6N00_RS03010 ENOG4107TK4 histidinol-phosphate phosphatase G6N00_RS03020 ENOG4105C1G acyl-Coa dehydrogenase G6N00_RS03025 ENOG4107S5I aldo keto reductase G6N00_RS03050 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G6N00_RS03055 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase G6N00_RS03065 ENOG4105C1G acyl-Coa dehydrogenase G6N00_RS03080 ENOG4108YYC ycei family G6N00_RS03100 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain G6N00_RS03120 ENOG4108IEH NADH dehydrogenase subunit g G6N00_RS03125 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) G6N00_RS03135 ENOG4105DF2 NADH dehydrogenase subunit j G6N00_RS03170 ENOG4105C7R Atpase associated with various cellular activities aaa_3 G6N00_RS03225 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) G6N00_RS03240 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) G6N00_RS03245 ENOG4105CH6 catalase G6N00_RS03280 ENOG4108J08 Csbd family G6N00_RS03290 ENOG4108JPZ Monovalent cation H antiporter subunit D G6N00_RS03295 ENOG4108ZE9 Monovalent cation H antiporter subunit C G6N00_RS03310 ENOG4105KJM monovalent cation h antiporter subunit g G6N00_RS03340 ENOG4108UN4 phage SPO1 DNA polymerase-related protein G6N00_RS03365 ENOG4105BZU Histidine kinase G6N00_RS03395 ENOG4105KNI merR family transcriptional Regulator G6N00_RS03415 ENOG4105WH1 Two component transcriptional regulator luxr family G6N00_RS03495 ENOG4108V06 Glutathione peroxidase G6N00_RS03540 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction G6N00_RS03545 ENOG4107XVH Transcriptional regulator G6N00_RS03580 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr G6N00_RS03605 ENOG41063PX domain protein G6N00_RS03625 ENOG4105WBQ Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) G6N00_RS03645 ENOG4107SVH Potassium channel protein G6N00_RS03665 ENOG4108YIQ Alpha beta hydrolase G6N00_RS03710 ENOG4105C1J atp-dependent rna helicase G6N00_RS03725 ENOG4108ZM9 phosphoglycerate mutase G6N00_RS03745 ENOG4107TE5 Lipid kinase G6N00_RS03760 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit G6N00_RS03775 ENOG4107EXU Short-chain dehydrogenase reductase Sdr G6N00_RS03780 ENOG4108Z66 YbaK ebsC protein G6N00_RS03785 ENOG4105CPQ Dehydrogenase G6N00_RS03800 ENOG4105H9W Short-chain dehydrogenase reductase Sdr G6N00_RS03830 ENOG4108RAV Conserved protein G6N00_RS03835 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase G6N00_RS03840 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) G6N00_RS03845 ENOG4105KVH Transcriptional regulator G6N00_RS03850 ENOG4105CHU acetyl-coa acetyltransferase G6N00_RS03865 ENOG4108RZE Tetr family transcriptional regulator G6N00_RS03900 ENOG4108SVW integral membrane protein G6N00_RS03905 ENOG4105DHT Metal Dependent Phosphohydrolase G6N00_RS03915 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving G6N00_RS03920 ENOG4108S7Q sigma 54 modulation protein ribosomal protein S30ea G6N00_RS03935 ENOG4105DND Transcriptional regulator G6N00_RS03950 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase G6N00_RS03960 ENOG4108IG5 Transcriptional regulator G6N00_RS03965 ENOG4105CEY Amp-dependent synthetase and ligase G6N00_RS03980 ENOG4105EMN RNA polymerase sigma factor G6N00_RS04000 ENOG4105DNP FAD linked oxidase domain protein G6N00_RS04010 ENOG4105G3P Lipoprotein lpqB G6N00_RS04015 ENOG4105BZU Histidine kinase G6N00_RS04030 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) G6N00_RS04040 ENOG4105VCQ rubredoxin G6N00_RS04045 ENOG41084UD rubredoxin G6N00_RS04050 ENOG4105EEF Alkane 1-monooxygenase G6N00_RS04055 ENOG4105CUB amino acid G6N00_RS04065 ENOG4105EIP mannose-6-phosphate isomerase G6N00_RS04075 ENOG4107QKV phosphomannomutase G6N00_RS04090 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) G6N00_RS04130 ENOG4107TB5 TRANSCRIPTIONal G6N00_RS04160 ENOG410846T CoA-transferase family III G6N00_RS04205 ENOG4105BZU Histidine kinase G6N00_RS04210 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family G6N00_RS04220 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) G6N00_RS04225 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit G6N00_RS04245 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein G6N00_RS04250 ENOG4105J5T Amp-dependent synthetase and ligase G6N00_RS04265 ENOG4105D8K carboxyl transferase G6N00_RS04275 ENOG4108Z03 MAF-like protein G6N00_RS04290 ENOG4108JIK carboxylase G6N00_RS04335 ENOG4105C26 Dehydrogenase G6N00_RS04345 ENOG4107QRT dEAD DEAH box helicase G6N00_RS04385 ENOG4105E8R UPF0173 metal-dependent hydrolase G6N00_RS04395 ENOG4108W1A pseudouridine synthase G6N00_RS04400 ENOG4105C6V Glycerol-3-phosphate dehydrogenase G6N00_RS04420 ENOG4107RM1 amidohydrolase G6N00_RS04425 ENOG4105CH2 amidohydrolase G6N00_RS04440 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain G6N00_RS04445 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) G6N00_RS04450 ENOG4105FBN Acid phosphatase G6N00_RS04515 ENOG4105E33 succinate dehydrogenase G6N00_RS04530 ENOG4108KPJ rna polymerase sigma factor G6N00_RS04535 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) G6N00_RS04545 ENOG4105DZ1 carboxypeptidase G6N00_RS04550 ENOG4107QNK )-transporter G6N00_RS04555 ENOG4105CE4 GlcNAc 6-P deacetylase G6N00_RS04565 ENOG4107H3J ribonuclease G6N00_RS04585 ENOG4105E9K Isocitrate dehydrogenase G6N00_RS04590 ENOG4108IQK o-acetylhomoserine G6N00_RS04635 ENOG4105IDI abc transporter atp-binding protein G6N00_RS04640 ENOG4105IDI abc transporter atp-binding protein G6N00_RS04645 ENOG4107Z6C Pentapeptide repeat-containing protein G6N00_RS04660 ENOG4105GWZ Roadblock lc7 family protein G6N00_RS04665 ENOG4105BZU Histidine kinase G6N00_RS04675 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) G6N00_RS04690 ENOG4105C0B DNA polymerase III (alpha subunit) G6N00_RS04705 ENOG4105GCF PGAM G6N00_RS04710 ENOG4105PDP Short chain dehydrogenase G6N00_RS04735 ENOG4105DMF Dehydrogenase G6N00_RS04755 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) G6N00_RS04800 ENOG4108VT4 G6N00_RS04840 ENOG4105H08 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) G6N00_RS04860 ENOG4105ST3 Transcriptional regulator G6N00_RS04885 ENOG41080E2 ribosomal-protein-alanine acetyltransferase G6N00_RS04895 ENOG4108097 ATP-binding protein G6N00_RS04910 ENOG4105CVK Glutamate decarboxylase G6N00_RS04930 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) G6N00_RS04955 ENOG4105DYW oxidoreductase G6N00_RS05000 ENOG4105EC2 ftsk spoIIIe G6N00_RS05010 ENOG41090GG peptidase S8 and S53, subtilisin, kexin, sedolisin G6N00_RS05125 ENOG410616I blue (type 1) copper domain protein G6N00_RS05130 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) G6N00_RS05145 ENOG4105C26 Dehydrogenase G6N00_RS05150 ENOG4105C1G acyl-Coa dehydrogenase G6N00_RS05165 ENOG4105CIH Imidazole acetol-phosphate transaminase G6N00_RS05180 ENOG4105C7K acetolactate synthase G6N00_RS05185 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) G6N00_RS05190 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) G6N00_RS05195 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) G6N00_RS05205 ENOG41061H0 Monooxygenase G6N00_RS05225 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) G6N00_RS05235 ENOG4108XW1 Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) G6N00_RS05270 ENOG4105PDP Short chain dehydrogenase G6N00_RS05290 ENOG4108XW1 Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) G6N00_RS05300 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) G6N00_RS05315 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) G6N00_RS05320 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) G6N00_RS05360 ENOG4105E6M Sulphatase-modifying factor protein G6N00_RS05365 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) G6N00_RS05370 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal G6N00_RS05435 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) G6N00_RS05460 ENOG4105XDV G6N00_RS05485 ENOG4105ECY inositol monophosphatase G6N00_RS05490 ENOG4108DNI pyridine nucleotide-disulfide oxidoreductase G6N00_RS05495 ENOG4108BAS reductase G6N00_RS05520 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) G6N00_RS05545 ENOG4105E39 Enoyl-CoA hydratase G6N00_RS05560 ENOG4105CSU acyl-Coa dehydrogenase G6N00_RS05600 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) G6N00_RS05665 ENOG4105CHP RNA polymerase G6N00_RS05700 ENOG4108F01 MaoC domain protein G6N00_RS05705 ENOG410900P UPF0336 protein G6N00_RS05730 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) G6N00_RS05745 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) G6N00_RS05770 ENOG4108DBC nitroreductase G6N00_RS05775 ENOG4108NUI synthase G6N00_RS05780 ENOG4105DSY exodeoxyribonuclease V, gamma G6N00_RS05785 ENOG4107QKA exodeoxyribonuclease V beta G6N00_RS05815 ENOG4105CWX Alpha-1,2-mannosidase G6N00_RS05835 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) G6N00_RS05870 ENOG4106A3M Cytochrome p-450 G6N00_RS05885 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) G6N00_RS05910 ENOG4105CT3 Monooxygenase G6N00_RS05920 ENOG4105CHH sulfate transporter G6N00_RS05930 ENOG4105D0M Protease HtpX homolog G6N00_RS05935 ENOG4105EAH synthase G6N00_RS05950 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) G6N00_RS05955 ENOG4105E1F short-chain dehydrogenase reductase G6N00_RS05980 ENOG4107TCW O-succinylbenzoate synthase G6N00_RS05985 ENOG4105CI2 imidazolone-5-propionate hydrolase G6N00_RS05990 ENOG4105CEY Amp-dependent synthetase and ligase G6N00_RS06000 ENOG4107S5I aldo keto reductase G6N00_RS06015 ENOG4105PDP Short chain dehydrogenase G6N00_RS06070 ENOG4108IAJ Nad-dependent epimerase dehydratase G6N00_RS06075 ENOG4107USC Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity) G6N00_RS06105 ENOG4105CRE cytochrome C G6N00_RS06115 ENOG4107QIV Cytochrome c biogenesis protein G6N00_RS06125 ENOG4108RH7 phosphoglycerate mutase G6N00_RS06145 ENOG4105CMJ mandelate racemase muconate lactonizing G6N00_RS06150 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) G6N00_RS06160 ENOG4105C85 amino acid G6N00_RS06185 ENOG4105EXC Acyl-transferase G6N00_RS06265 ENOG410900P UPF0336 protein G6N00_RS06310 ENOG41063NU Membrane G6N00_RS06335 ENOG4107RPC Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) G6N00_RS06340 ENOG4108YZJ Pfam:DUF2596 G6N00_RS06345 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) G6N00_RS06390 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) G6N00_RS06400 ENOG4105TT9 Protein of unknown function (DUF2516) G6N00_RS06405 ENOG4105V9F hemagglutinin G6N00_RS06415 ENOG4106BRA Membrane G6N00_RS06430 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase G6N00_RS06500 ENOG4108D7R p-hydroxycinnamoyl CoA hydratase lyase G6N00_RS06510 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) G6N00_RS06575 ENOG4105EMU Dehydrogenase G6N00_RS06605 ENOG41061TZ Short-chain dehydrogenase reductase Sdr G6N00_RS06615 ENOG4106UW1 Major Facilitator superfamily G6N00_RS06680 ENOG4105H08 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) G6N00_RS06695 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) G6N00_RS06795 ENOG4105C1B dTDP-glucose 4-6-dehydratase G6N00_RS06800 ENOG4105IIU Aminopeptidase G6N00_RS06805 ENOG4105IIU Aminopeptidase G6N00_RS06845 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) G6N00_RS06865 ENOG4105CT1 (ABC) transporter G6N00_RS06880 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) G6N00_RS06915 ENOG4105CHR reductase G6N00_RS06920 ENOG4105C1G acyl-Coa dehydrogenase G6N00_RS06945 ENOG4105CEP NADH dehydrogenase G6N00_RS06955 ENOG4105MGE Rhodanese domain protein G6N00_RS06975 ENOG4105GCF PGAM G6N00_RS06985 ENOG4107XZ0 Peptidase M50 G6N00_RS07050 ENOG4105C1G acyl-Coa dehydrogenase G6N00_RS07055 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit G6N00_RS07075 ENOG4105KNI merR family transcriptional Regulator G6N00_RS07080 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) G6N00_RS07085 ENOG4108093 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ G6N00_RS07120 ENOG4105C54 Major Facilitator superfamily G6N00_RS07135 ENOG4105DF6 Fe-S oxidoreductase G6N00_RS07165 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) G6N00_RS07170 ENOG4105CSH Transporter G6N00_RS07180 ENOG4105C6Y Udp-glucose 6-dehydrogenase G6N00_RS07225 ENOG41069FZ L,D-transpeptidase catalytic domain G6N00_RS07245 ENOG4105DEI Mannitol dehydrogenase G6N00_RS07290 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein G6N00_RS07330 ENOG4105HMD G6N00_RS07355 ENOG4105E7Q Cob(II)yrinic acid a,c-diamide reductase G6N00_RS07360 ENOG4105E0M Sulfatase G6N00_RS07380 ENOG41090GG peptidase S8 and S53, subtilisin, kexin, sedolisin G6N00_RS07430 ENOG4105IIV Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) G6N00_RS07435 ENOG4105NRA 50s ribosomal protein l31 type b G6N00_RS07450 ENOG4105W0E 50S ribosomal protein L33 G6N00_RS07455 ENOG41080FR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) G6N00_RS07460 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) G6N00_RS07515 ENOG4105D2B acyl-CoA dehydrogenase G6N00_RS07525 ENOG4105CEY Amp-dependent synthetase and ligase G6N00_RS07535 ENOG4107QND Nitrite extrusion protein G6N00_RS07550 ENOG4107R7A Allophanate hydrolase subunit 2 G6N00_RS07585 ENOG4107QZF nitrite reductase NADPH large subunit G6N00_RS07610 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) G6N00_RS07630 ENOG4105CSU acyl-Coa dehydrogenase G6N00_RS07635 ENOG4105CHU acetyl-coa acetyltransferase G6N00_RS07640 ENOG4105CHR reductase G6N00_RS07675 ENOG41073B4 coagulation factor 5 8 type domain-containing protein G6N00_RS07685 ENOG4105GVF (ABC) transporter G6N00_RS07750 ENOG4105C26 Dehydrogenase G6N00_RS07755 ENOG4108CCU Ribonucleotide-diphosphate reductase subunit beta G6N00_RS07780 ENOG4105CEY Amp-dependent synthetase and ligase G6N00_RS07810 ENOG4107XFB conserved TRANSMEMBRANE PROTEIN G6N00_RS07830 ENOG4105J7D transcriptional regulator G6N00_RS07855 ENOG4105E39 Enoyl-CoA hydratase G6N00_RS07875 ENOG4106HB6 Alpha beta hydrolase G6N00_RS07885 ENOG4105CI2 imidazolone-5-propionate hydrolase G6N00_RS07900 ENOG4105C1G acyl-Coa dehydrogenase G6N00_RS07910 ENOG4105E39 Enoyl-CoA hydratase G6N00_RS07920 ENOG410620I Diguanylate cyclase G6N00_RS07925 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) G6N00_RS07940 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) G6N00_RS07950 ENOG4108I9W Membrane G6N00_RS07990 ENOG4105C9K Endothelin-converting enzyme 1 G6N00_RS07995 ENOG4107QY8 reductase G6N00_RS08005 ENOG4105S7A ErfK ybiS ycfS ynhG family protein G6N00_RS08015 ENOG4105VPX protein, conserved in bacteria G6N00_RS08020 ENOG4105C01 Dihydroxy-acid dehydratase G6N00_RS08030 ENOG4107QWG 2-Nitropropane dioxygenase G6N00_RS08060 ENOG4105E5G Alpha beta hydrolase fold G6N00_RS08100 ENOG4105XPP Protein of unknown function (DUF1275) G6N00_RS08115 ENOG4105W8D rdd domain containing protein G6N00_RS08160 ENOG4105CY3 ABC transporter, permease G6N00_RS08195 ENOG4107RN6 Monooxygenase G6N00_RS08200 ENOG4105CHR reductase G6N00_RS08215 ENOG4105E2A Dehydrogenase G6N00_RS08250 ENOG4105X7H acyl-CoA dehydrogenase G6N00_RS08255 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone G6N00_RS08285 ENOG4105CQB FAD linked oxidase domain protein G6N00_RS08305 ENOG4108R86 Transcriptional regulator G6N00_RS08315 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) G6N00_RS08320 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) G6N00_RS08325 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) G6N00_RS08335 ENOG4105C1G acyl-Coa dehydrogenase G6N00_RS08340 ENOG4105M2Z protein tyrosine serine phosphatase G6N00_RS08345 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr G6N00_RS08350 ENOG4105C26 Dehydrogenase G6N00_RS08375 ENOG4105EUB pirin domain protein G6N00_RS08380 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction G6N00_RS08415 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) G6N00_RS08430 ENOG4105X1Q TOBE domain protein G6N00_RS08435 ENOG4105D74 hydrolase G6N00_RS08455 ENOG4105DYW oxidoreductase G6N00_RS08475 ENOG4105EJ2 Transcriptional regulator G6N00_RS08500 ENOG4105WEF catalase G6N00_RS08530 ENOG4105CJ1 ABC, transporter G6N00_RS08550 ENOG41070F3 Catalyzes the ATP-dependent phosphorylation of maltose to maltose 1-phosphate. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, GlgE and GlgB (By similarity) G6N00_RS08580 ENOG4105CFN oxalyl-CoA decarboxylase G6N00_RS08585 ENOG4105CN8 Transcriptional regulator G6N00_RS08590 ENOG4105FF0 ErfK YbiS YcfS YnhG G6N00_RS08625 ENOG4105EXC Acyl-transferase G6N00_RS08635 ENOG4105C7K acetolactate synthase G6N00_RS08640 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G6N00_RS08645 ENOG4105CHR reductase G6N00_RS08650 ENOG4107R5W Monooxygenase G6N00_RS08660 ENOG4105H9W Short-chain dehydrogenase reductase Sdr G6N00_RS08675 ENOG4105CEY Amp-dependent synthetase and ligase G6N00_RS08685 ENOG4105CEY Amp-dependent synthetase and ligase G6N00_RS08730 ENOG4105CEY Amp-dependent synthetase and ligase G6N00_RS08745 ENOG4108VHC Short-chain dehydrogenase reductase Sdr G6N00_RS08765 ENOG4107QNM Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) G6N00_RS08775 ENOG4108IXY short-chain dehydrogenase reductase G6N00_RS08790 ENOG4108QIU Dehydrogenase G6N00_RS08815 ENOG4105CPQ Dehydrogenase G6N00_RS08835 ENOG4105CHR reductase G6N00_RS08840 ENOG4105F95 Monooxygenase G6N00_RS08865 ENOG4105EF7 Transcriptional regulator G6N00_RS08885 ENOG41076PI Short-chain dehydrogenase reductase Sdr G6N00_RS08905 ENOG4108SEA Esterase G6N00_RS08925 ENOG4108Q5F Tetr family transcriptional regulator G6N00_RS08940 ENOG4105J5T Amp-dependent synthetase and ligase G6N00_RS08965 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G6N00_RS08975 ENOG4105ETE Transcriptional regulator (LacI family G6N00_RS08990 ENOG4105D2B acyl-CoA dehydrogenase G6N00_RS08995 ENOG4108JGH Tetr family transcriptional regulator G6N00_RS09060 ENOG4105DVW rieske (2Fe-2S) G6N00_RS09070 ENOG4105WH1 Two component transcriptional regulator luxr family G6N00_RS09075 ENOG4105BZU Histidine kinase G6N00_RS09135 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate G6N00_RS09185 ENOG4108E1C hydrolase G6N00_RS09200 ENOG4107QJE Chromosome Partitioning Protein G6N00_RS09205 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) G6N00_RS09215 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins G6N00_RS09220 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) G6N00_RS09235 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) G6N00_RS09240 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) G6N00_RS09250 ENOG4105K7N UPF0232 protein G6N00_RS09255 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) G6N00_RS09260 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) G6N00_RS09295 ENOG4107XH4 PPIases accelerate the folding of proteins (By similarity) G6N00_RS09325 ENOG4107TPY serine threonine protein kinase G6N00_RS09350 ENOG4105TV9 FHA Domain-Containing protein G6N00_RS09380 ENOG4107RCI amp-dependent synthetase and ligase G6N00_RS09405 ENOG4105EUB pirin domain protein G6N00_RS09410 ENOG4105C1G acyl-Coa dehydrogenase G6N00_RS09480 ENOG41064CH Probable lipoprotein LpqN G6N00_RS09485 ENOG4105C8T Leucyl-tRNA synthetase G6N00_RS09500 ENOG4105CDA abc transporter atp-binding protein G6N00_RS09505 ENOG4105DRP amino acid AbC transporter G6N00_RS09515 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone G6N00_RS09520 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase G6N00_RS09525 ENOG4105CMR udp-glucose 4-epimerase G6N00_RS09530 ENOG4108JGH Tetr family transcriptional regulator G6N00_RS09580 ENOG4105BZ4 penicillin-binding protein G6N00_RS09595 ENOG410829C Binds together with S18 to 16S ribosomal RNA (By similarity) G6N00_RS09620 ENOG4105MKU Transcriptional regulator G6N00_RS09635 ENOG4105VEQ Cold shock protein G6N00_RS09645 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) G6N00_RS09655 ENOG4105CHR reductase G6N00_RS09660 ENOG4105CHR reductase G6N00_RS09705 ENOG4105DNP FAD linked oxidase domain protein G6N00_RS09715 ENOG410832A alpha/beta hydrolase fold G6N00_RS09730 ENOG4107Y3V -acetyltransferase G6N00_RS09805 ENOG41067SE Tetr family transcriptional regulator G6N00_RS09860 ENOG4105CHH sulfate transporter G6N00_RS09870 ENOG4105C5I Dehydrogenase G6N00_RS09885 ENOG4105FAE von Willebrand factor, type A G6N00_RS09890 ENOG4105GMT ATPase associated with various cellular activities aaa_5 G6N00_RS09900 ENOG4108IG5 Transcriptional regulator G6N00_RS09910 ENOG4105CSH Transporter G6N00_RS09930 ENOG41062IE glyoxalase bleomycin resistance protein dioxygenase G6N00_RS09970 ENOG4105DYW oxidoreductase G6N00_RS09990 ENOG4105HHS UPF0256 protein G6N00_RS09995 ENOG4105C1G acyl-Coa dehydrogenase G6N00_RS10000 ENOG4108IG5 Transcriptional regulator G6N00_RS10085 ENOG4105CBC glutamate synthase G6N00_RS10105 ENOG4105DCG PHP domain protein G6N00_RS10120 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) G6N00_RS10130 ENOG4105CT3 Monooxygenase G6N00_RS10190 ENOG4108KGH TRANSCRIPTIONal G6N00_RS10265 ENOG4105E9Q Acyl-transferase G6N00_RS10280 ENOG410667J hydrolase G6N00_RS10300 ENOG410602S Transferase G6N00_RS10315 ENOG4107ISF Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component the mycobacterial cell wall. Catalyzes the transfer of arabinofuranosyl (Araf) residues residue from the sugar donor beta-D-arabinofuranosyl-1-monophosphoryldecaprenol (DPA) to the arabinan domain to form terminal beta-(1- 2)-linked Araf residues, which marks the end point for AG arabinan biosynthesis before decoration with mycolic acids G6N00_RS10335 ENOG4107RCI amp-dependent synthetase and ligase G6N00_RS10345 ENOG4105D8K carboxyl transferase G6N00_RS10360 ENOG4105C1G acyl-Coa dehydrogenase G6N00_RS10380 ENOG4105J1Z Arabinosyltransferase G6N00_RS10385 ENOG4108NUW Cell wall arabinan synthesis protein G6N00_RS10400 ENOG4105MHT Transcriptional regulator, ARSR family G6N00_RS10415 ENOG4108RG3 short-chain dehydrogenase reductase G6N00_RS10420 ENOG4105IQ5 FAD linked oxidase domain protein G6N00_RS10470 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein G6N00_RS10505 ENOG4105F9F transposase G6N00_RS10515 ENOG4105CIH Imidazole acetol-phosphate transaminase G6N00_RS10555 ENOG4105CK6 Two component transcriptional regulator (Winged helix family G6N00_RS10560 ENOG4105BZU Histidine kinase G6N00_RS10570 ENOG4105EUZ Beta-lactamase domain protein G6N00_RS10590 ENOG4105CHR reductase G6N00_RS10615 ENOG41060H3 Protein of unknown function (DUF1049) G6N00_RS10625 ENOG4108IJ8 ABC transporter G6N00_RS10630 ENOG4105E90 ABC transporter G6N00_RS10645 ENOG4105EVN Prephenate dehydrogenase G6N00_RS10655 ENOG4108Z6B deaminase G6N00_RS10665 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) G6N00_RS10680 ENOG4105MPZ Pfam:DUF1023 G6N00_RS10710 ENOG4108M8W Monooxygenase G6N00_RS10725 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G6N00_RS10730 ENOG4105CI0 Citrate lyase G6N00_RS10735 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) G6N00_RS10740 ENOG4105BZN citrate synthase G6N00_RS10745 ENOG4105CR4 methylisocitrate lyase G6N00_RS10755 ENOG4105CFF transcriptional regulator G6N00_RS10760 ENOG4108RVA ribokinase G6N00_RS10765 ENOG4108JQ1 Dehydrogenase G6N00_RS10785 ENOG4108KR4 dihydrodipicolinate reductase G6N00_RS10810 ENOG4106A3M Cytochrome p-450 G6N00_RS10850 ENOG4105D3W isochorismatase G6N00_RS10870 ENOG4105CMR udp-glucose 4-epimerase G6N00_RS10915 ENOG4105XT2 Transcriptional regulator G6N00_RS10925 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase G6N00_RS10940 ENOG4108RU2 n-acetylmuramoyl-l-alanine amidase G6N00_RS10945 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) G6N00_RS10965 ENOG4105DMS mur ligase G6N00_RS10970 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) G6N00_RS10990 ENOG4108NJC G6N00_RS11015 ENOG4105E46 N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process G6N00_RS11020 ENOG4108V75 Glutamine amidotransferase G6N00_RS11030 ENOG4105C92 Aminotransferase class V G6N00_RS11045 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) G6N00_RS11050 ENOG4105NTW Transcriptional regulator G6N00_RS11075 ENOG4105C7R Atpase associated with various cellular activities aaa_3 G6N00_RS11080 ENOG4108WQ6 secreted protein G6N00_RS11100 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone G6N00_RS11110 ENOG4107R7Y intracellular protease Pfpi family G6N00_RS11115 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) G6N00_RS11140 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase G6N00_RS11145 ENOG4105FUA antagonist G6N00_RS11150 ENOG4107MMM Anti-sigma-factor antagonist G6N00_RS11165 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 G6N00_RS11230 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) G6N00_RS11245 ENOG4105CSM endonuclease III G6N00_RS11255 ENOG4105P8F nudix hydrolase G6N00_RS11280 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) G6N00_RS11300 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component G6N00_RS11305 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component G6N00_RS11310 ENOG4108JQ6 ABC transporter G6N00_RS11445 ENOG4108I5C dEAD DEAH box helicase G6N00_RS11470 ENOG4107QRG dna polymerase iii G6N00_RS11530 ENOG4107RD1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) G6N00_RS11535 ENOG4108UGV hypoxanthine phosphoribosyltransferase G6N00_RS11570 ENOG4105CPQ Dehydrogenase G6N00_RS11580 ENOG4105D74 hydrolase G6N00_RS11595 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) G6N00_RS11600 ENOG4105EUJ GTP cyclohydrolase i G6N00_RS11605 ENOG4105EEI dihydropteroate synthase G6N00_RS11635 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) G6N00_RS11715 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) G6N00_RS11750 ENOG4105E7W lamb ycsf family protein G6N00_RS11760 ENOG4105CC5 ABC transporter G6N00_RS11765 ENOG4105FDK ABC transporter G6N00_RS11780 ENOG4108SGK Tetr family transcriptional regulator G6N00_RS11785 ENOG4105D2B acyl-CoA dehydrogenase G6N00_RS11840 ENOG4105D2B acyl-CoA dehydrogenase G6N00_RS11845 ENOG4105D2B acyl-CoA dehydrogenase G6N00_RS11850 ENOG4105CC9 acyl-Coa dehydrogenase G6N00_RS11855 ENOG4105CEY Amp-dependent synthetase and ligase G6N00_RS11860 ENOG4105CC9 acyl-Coa dehydrogenase G6N00_RS11875 ENOG4105F2C Acetyl-CoA acetyltransferase G6N00_RS11890 ENOG4105EA8 2-Nitropropane dioxygenase G6N00_RS11905 ENOG4105E39 Enoyl-CoA hydratase G6N00_RS11915 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr G6N00_RS11935 ENOG4105F2C Acetyl-CoA acetyltransferase G6N00_RS11945 ENOG4108RK3 acyl-Coa dehydrogenase G6N00_RS11950 ENOG4105X7H acyl-CoA dehydrogenase G6N00_RS11955 ENOG410900P UPF0336 protein G6N00_RS11980 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein G6N00_RS11985 ENOG4105IKQ hydratase G6N00_RS11995 ENOG4105DF3 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity) G6N00_RS12010 ENOG4105CHR reductase G6N00_RS12025 ENOG4105CIJ rieske 2fe-2S domain-containing protein G6N00_RS12030 ENOG4108Z0R Transferase G6N00_RS12035 ENOG4105X1P Steroid delta-isomerase G6N00_RS12055 ENOG4105DYW oxidoreductase G6N00_RS12065 ENOG410719E cytochrome p450 G6N00_RS12110 ENOG4105J5T Amp-dependent synthetase and ligase G6N00_RS12115 ENOG4108KC2 acyl-Coa dehydrogenase G6N00_RS12120 ENOG4105X7H acyl-CoA dehydrogenase G6N00_RS12215 ENOG4107TB5 TRANSCRIPTIONal G6N00_RS12285 ENOG4105CK6 Two component transcriptional regulator (Winged helix family G6N00_RS12290 ENOG4105BZU Histidine kinase G6N00_RS12320 ENOG41068W2 Cytochrome p-450 G6N00_RS12325 ENOG4105E1F short-chain dehydrogenase reductase G6N00_RS12340 ENOG4105C26 Dehydrogenase G6N00_RS12360 ENOG4105CPC Aldo Keto reductase G6N00_RS12375 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) G6N00_RS12395 ENOG4105C83 adenylosuccinate lyase G6N00_RS12415 ENOG4105C8V SAICAR synthetase G6N00_RS12425 ENOG4105C0R drug resistance transporter emrb qaca subfamily G6N00_RS12430 ENOG4105C0R drug resistance transporter emrb qaca subfamily G6N00_RS12445 ENOG4107T8T UPF0173 metal-dependent hydrolase G6N00_RS12455 ENOG410839H phosphoribosylformylglycinamidine synthase G6N00_RS12460 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I G6N00_RS12470 ENOG4105PSQ Acyl-transferase G6N00_RS12475 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) G6N00_RS12530 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) G6N00_RS12540 ENOG4105EZR dyp-type peroxidase family protein G6N00_RS12590 ENOG4105CXB phosphoribosylaminoimidazole synthetase G6N00_RS12600 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) G6N00_RS12615 ENOG4105PKJ carbohydrate binding G6N00_RS12630 ENOG4105K63 Thioredoxin G6N00_RS12640 ENOG4107NHD transcriptional regulator G6N00_RS12665 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) G6N00_RS12710 ENOG41082SX arsR family transcriptional regulator G6N00_RS12715 ENOG4107Y2X deaminase G6N00_RS12745 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) G6N00_RS12765 ENOG4105CMD Transcriptional regulator, GntR family G6N00_RS12810 ENOG4105C0D helicase G6N00_RS12840 ENOG41076PI Short-chain dehydrogenase reductase Sdr G6N00_RS12855 ENOG4106A3M Cytochrome p-450 G6N00_RS12860 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family G6N00_RS12865 ENOG4108XB2 Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) G6N00_RS12895 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone G6N00_RS12900 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G6N00_RS12930 ENOG4105CEY Amp-dependent synthetase and ligase G6N00_RS12935 ENOG4105D2B acyl-CoA dehydrogenase G6N00_RS12940 ENOG4105CC9 acyl-Coa dehydrogenase G6N00_RS12955 ENOG4105PY6 Phenolic acid decarboxylase G6N00_RS12960 ENOG4105CHU acetyl-coa acetyltransferase G6N00_RS12965 ENOG4105DJT lAO AO transport system ATPase G6N00_RS12970 ENOG4107RUY (E1 component), alpha subunit G6N00_RS12990 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) G6N00_RS12995 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein G6N00_RS13015 ENOG4105MI0 Catalyzes the non-heme iron(II)-dependent oxidative cleavage of 2,3-dihydroxyphenylpropionic acid and 2,3- dihydroxicinnamic acid into 2-hydroxy-6-ketononadienedioate and 2- hydroxy-6-ketononatrienedioate, respectively (By similarity) G6N00_RS13020 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein G6N00_RS13030 ENOG4105CHR reductase G6N00_RS13045 ENOG4107R16 Multicopper oxidase G6N00_RS13050 ENOG4105CHR reductase G6N00_RS13060 ENOG4105WH1 Two component transcriptional regulator luxr family G6N00_RS13065 ENOG4105CHR reductase G6N00_RS13125 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G6N00_RS13130 ENOG4105CHR reductase G6N00_RS13140 ENOG41076PI Short-chain dehydrogenase reductase Sdr G6N00_RS13150 ENOG4105CC9 acyl-Coa dehydrogenase G6N00_RS13165 ENOG4105CC9 acyl-Coa dehydrogenase G6N00_RS13175 ENOG4105CPN adenine deaminase G6N00_RS13185 ENOG4105DVW rieske (2Fe-2S) G6N00_RS13205 ENOG4105CGU Enoyl-CoA hydratase G6N00_RS13210 ENOG4105CHU acetyl-coa acetyltransferase G6N00_RS13215 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) G6N00_RS13245 ENOG4106A3M Cytochrome p-450 G6N00_RS13250 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase G6N00_RS13290 ENOG4105D2B acyl-CoA dehydrogenase G6N00_RS13300 ENOG4107EEP NADH dehydrogenase (quinone) (EC 1.6.99.5) G6N00_RS13340 ENOG41088YA Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives (By similarity) G6N00_RS13345 ENOG4105D2B acyl-CoA dehydrogenase G6N00_RS13350 ENOG4105CC9 acyl-Coa dehydrogenase G6N00_RS13400 ENOG410846T CoA-transferase family III G6N00_RS13405 ENOG4105CY3 ABC transporter, permease G6N00_RS13505 ENOG4105E39 Enoyl-CoA hydratase G6N00_RS13520 ENOG4105CEY Amp-dependent synthetase and ligase G6N00_RS13545 ENOG410846T CoA-transferase family III G6N00_RS13565 ENOG4105CHU acetyl-coa acetyltransferase G6N00_RS13570 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase G6N00_RS13575 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) G6N00_RS13595 ENOG4108M8W Monooxygenase G6N00_RS13625 ENOG4105CFI type iii restriction protein res subunit G6N00_RS13645 ENOG4105EPU Molybdenum cofactor synthesis domain protein G6N00_RS13665 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) G6N00_RS13670 ENOG410901E Membrane G6N00_RS13675 ENOG4105VEQ Cold shock protein G6N00_RS13685 ENOG4105CHF Glutathione S-transferase G6N00_RS13700 ENOG4108N0W Major Facilitator superfamily G6N00_RS13740 ENOG4107R8H Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) G6N00_RS13765 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) G6N00_RS13855 ENOG4105CHU acetyl-coa acetyltransferase G6N00_RS13920 ENOG4107QJG Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) G6N00_RS13925 ENOG4107QJG Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) G6N00_RS13935 ENOG4105E2Z phosphate ABC transporter (Permease G6N00_RS14025 ENOG41063SB peptidase G6N00_RS14050 ENOG41078VV 34 kDa antigenic protein G6N00_RS14065 ENOG4105DC1 bifunctional purine biosynthesis protein purh G6N00_RS14075 ENOG4105C0P Mg chelatase subunit ChlI G6N00_RS14085 ENOG4105CV8 reductase G6N00_RS14095 ENOG41060WC Enoyl-CoA hydratase G6N00_RS14110 ENOG4107QX3 carboxylase G6N00_RS14115 ENOG4105C1G acyl-Coa dehydrogenase G6N00_RS14125 ENOG41067C8 50S ribosomal protein L32 G6N00_RS14150 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) G6N00_RS14155 ENOG41080FJ Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) G6N00_RS14170 ENOG41080UU 5-formyltetrahydrofolate cyclo-ligase G6N00_RS14175 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase G6N00_RS14250 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) G6N00_RS14255 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase G6N00_RS14260 ENOG410870F Cyclic nucleotide-binding protein G6N00_RS14295 ENOG4105CRQ synthase (Component I) G6N00_RS14340 ENOG4107RA4 Glycosyl transferase (Group 1 G6N00_RS14380 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) G6N00_RS14405 ENOG41064MX Tetr family transcriptional regulator G6N00_RS14445 ENOG4105F8V Hydrolase, tatD family G6N00_RS14460 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) G6N00_RS14470 ENOG4107RCI amp-dependent synthetase and ligase G6N00_RS14475 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) G6N00_RS14480 ENOG4107XT7 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) G6N00_RS14525 ENOG4108IG5 Transcriptional regulator G6N00_RS14545 ENOG4105DXN mazG family G6N00_RS14590 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) G6N00_RS14595 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) G6N00_RS14615 ENOG4105BZU Histidine kinase G6N00_RS14620 ENOG4105CK6 Two component transcriptional regulator (Winged helix family G6N00_RS14660 ENOG4105CGD Nad-dependent epimerase dehydratase G6N00_RS14720 ENOG4105CEY Amp-dependent synthetase and ligase G6N00_RS14730 ENOG4105E7A Glutamine amidotransferase G6N00_RS14775 ENOG4105E39 Enoyl-CoA hydratase G6N00_RS14790 ENOG4105CHU acetyl-coa acetyltransferase G6N00_RS14840 ENOG4105C7Z Conserved Protein G6N00_RS14845 ENOG4105X1P Steroid delta-isomerase G6N00_RS14855 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) G6N00_RS14865 ENOG4105CS9 pantothenic acid kinase G6N00_RS14880 ENOG4108IAB Phoh family G6N00_RS14930 ENOG4105EBR Carboxylesterase G6N00_RS14945 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) G6N00_RS14955 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) G6N00_RS14965 ENOG4105C3G gtp-binding protein G6N00_RS15035 ENOG4108J5G 6-phosphogluconate dehydrogenase G6N00_RS15065 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) G6N00_RS15095 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) G6N00_RS15110 ENOG4108RZE Tetr family transcriptional regulator G6N00_RS15120 ENOG4105D2B acyl-CoA dehydrogenase G6N00_RS15125 ENOG4105CC9 acyl-Coa dehydrogenase G6N00_RS15130 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr G6N00_RS15160 ENOG4106A3M Cytochrome p-450 G6N00_RS15165 ENOG4105C26 Dehydrogenase G6N00_RS15190 ENOG4105CHU acetyl-coa acetyltransferase G6N00_RS15215 ENOG4105CGD Nad-dependent epimerase dehydratase G6N00_RS15225 ENOG4105CGD Nad-dependent epimerase dehydratase G6N00_RS15230 ENOG4108UKI Enoyl-CoA hydratase G6N00_RS15235 ENOG410846T CoA-transferase family III G6N00_RS15245 ENOG4107R13 MMPL domain protein G6N00_RS15255 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) G6N00_RS15270 ENOG410905P Pyridoxamine 5-phosphate G6N00_RS15330 ENOG4108IUE nitrate reductase beta subunit G6N00_RS15360 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) G6N00_RS15370 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) G6N00_RS15385 ENOG4108Z4U Ferredoxin G6N00_RS15395 ENOG4105C0X amino acid G6N00_RS15415 ENOG4107XCC Catalyzes the synthesis of activated sulfate (By similarity) G6N00_RS15420 ENOG4107RIQ Sulfate adenylate transferase G6N00_RS15435 ENOG4107RCI amp-dependent synthetase and ligase G6N00_RS15450 ENOG4105C26 Dehydrogenase G6N00_RS15460 ENOG4108JGH Tetr family transcriptional regulator G6N00_RS15485 ENOG4105C26 Dehydrogenase G6N00_RS15495 ENOG4105CEY Amp-dependent synthetase and ligase G6N00_RS15500 ENOG4105CSH Transporter G6N00_RS15535 ENOG4108URH decarboxylase G6N00_RS15550 ENOG4105C3Q Glycosyl transferase, family 2 G6N00_RS15560 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) G6N00_RS15575 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) G6N00_RS15585 ENOG4105DIM ABC transporter G6N00_RS15590 ENOG4105CIG ABC transporter G6N00_RS15595 ENOG4108X07 Tetr family transcriptional regulator G6N00_RS15610 ENOG4106684 G6N00_RS15615 ENOG4105C0H protease G6N00_RS15640 ENOG4105CJW magnesium transporter G6N00_RS15680 ENOG4105D7N magnesium and cobalt transport protein CorA G6N00_RS15685 ENOG4105D9Z Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) G6N00_RS15710 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 G6N00_RS15730 ENOG41072EW lipoprotein LprE G6N00_RS15755 ENOG4105CQB FAD linked oxidase domain protein G6N00_RS15770 ENOG4105DEN Luciferase family G6N00_RS15775 ENOG4105BZU Histidine kinase G6N00_RS15950 ENOG4105C75 arginyL-tRNA synthetase G6N00_RS15955 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) G6N00_RS15960 ENOG4105D6E homoserine dehydrogenase G6N00_RS15970 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) G6N00_RS15975 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) G6N00_RS15990 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) G6N00_RS16005 ENOG4105YV6 ATP synthase i G6N00_RS16010 ENOG4107RAZ it plays a direct role in the translocation of protons across the membrane (By similarity) G6N00_RS16015 ENOG410679R F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) G6N00_RS16025 ENOG4108T62 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) G6N00_RS16060 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) G6N00_RS16105 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) G6N00_RS16150 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) G6N00_RS16160 ENOG4108IUN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) G6N00_RS16170 ENOG4107RKP Nicotinate phosphoribosyltransferase G6N00_RS16200 ENOG4108RQ5 Beta-lactamase domain-containing protein G6N00_RS16205 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) G6N00_RS16210 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) G6N00_RS16215 ENOG4105WX6 Membrane G6N00_RS16235 ENOG4105KIR Thiol-disulfide oxidoreductase dcc G6N00_RS16265 ENOG41076PI Short-chain dehydrogenase reductase Sdr G6N00_RS16270 ENOG4105C1G acyl-Coa dehydrogenase G6N00_RS16280 ENOG4105CHU acetyl-coa acetyltransferase G6N00_RS16285 ENOG4105IYB L-carnitine dehydratase bile acid-inducible protein F G6N00_RS16290 ENOG4105C1G acyl-Coa dehydrogenase G6N00_RS16295 ENOG4108WYP Transcriptional regulator G6N00_RS16320 ENOG4105CEY Amp-dependent synthetase and ligase G6N00_RS16325 ENOG4105CEY Amp-dependent synthetase and ligase G6N00_RS16330 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) G6N00_RS16340 ENOG4105E39 Enoyl-CoA hydratase G6N00_RS16345 ENOG4105CGU Enoyl-CoA hydratase G6N00_RS16365 ENOG4105CHR reductase G6N00_RS16370 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) G6N00_RS16380 ENOG4108UKI Enoyl-CoA hydratase G6N00_RS16405 ENOG4105X7H acyl-CoA dehydrogenase G6N00_RS16465 ENOG4108K3M Rieske [2Fe-2S] domain G6N00_RS16475 ENOG4107S2E monooxygenase G6N00_RS16495 ENOG4107QX3 carboxylase G6N00_RS16530 ENOG4105Q56 cytochrome P450 G6N00_RS16540 ENOG4105D2B acyl-CoA dehydrogenase G6N00_RS16545 ENOG4105D2B acyl-CoA dehydrogenase G6N00_RS16565 ENOG4105CEY Amp-dependent synthetase and ligase G6N00_RS16570 ENOG4105C1G acyl-Coa dehydrogenase G6N00_RS16575 ENOG4105CC9 acyl-Coa dehydrogenase G6N00_RS16580 ENOG4105D2B acyl-CoA dehydrogenase G6N00_RS16585 ENOG4105D2B acyl-CoA dehydrogenase G6N00_RS16675 ENOG4108WKN secreted protein G6N00_RS16735 ENOG4107R13 MMPL domain protein G6N00_RS16740 ENOG4105PP6 Membrane G6N00_RS16745 ENOG4107UBC ErfK ybiS ycfS ynhG family protein G6N00_RS16765 ENOG4105D7A ATP-binding protein G6N00_RS16770 ENOG4105E1F short-chain dehydrogenase reductase G6N00_RS16790 ENOG4107QX3 carboxylase G6N00_RS16800 ENOG4105C1G acyl-Coa dehydrogenase G6N00_RS16805 ENOG4105DJG MaoC domain protein dehydratase G6N00_RS16825 ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 G6N00_RS16880 ENOG4107YH6 single-stranded DNA-binding protein G6N00_RS16890 ENOG4105C7I Dehydrogenase G6N00_RS16910 ENOG4105CG3 alpha amylase, catalytic region G6N00_RS16915 ENOG4108Z18 K06886 hemoglobin G6N00_RS16940 ENOG4105MC2 DSBA oxidoreductase G6N00_RS16945 ENOG4108YZG isomerase G6N00_RS16980 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) G6N00_RS16985 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) G6N00_RS16990 ENOG4107QK5 Homocysteine s-methyltransferase G6N00_RS17005 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein G6N00_RS17010 ENOG4105DQU oxidoreductase, subunit beta G6N00_RS17030 ENOG4105EG6 Saccharopine dehydrogenase G6N00_RS17035 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) G6N00_RS17040 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase G6N00_RS17050 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) G6N00_RS17055 ENOG4105C03 ribonuclease G6N00_RS17070 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control G6N00_RS17100 ENOG4108DWA Nad synthetase G6N00_RS17105 ENOG4108RVA ribokinase G6N00_RS17110 ENOG4105BZU Histidine kinase G6N00_RS17115 ENOG4105D8X mechanosensitive ion channel G6N00_RS17120 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) G6N00_RS17125 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit G6N00_RS17135 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) G6N00_RS17140 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) G6N00_RS17150 ENOG4108TZC G6N00_RS17175 ENOG4107RCI amp-dependent synthetase and ligase G6N00_RS17210 ENOG4105C1G acyl-Coa dehydrogenase G6N00_RS17215 ENOG4105CC9 acyl-Coa dehydrogenase G6N00_RS17220 ENOG4105KQC Competence protein G6N00_RS17225 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 G6N00_RS17255 ENOG4105KVH Transcriptional regulator G6N00_RS17270 ENOG4107XDQ Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) G6N00_RS17275 ENOG41080XP Cbs domain G6N00_RS17285 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) G6N00_RS17300 ENOG4105BZP glycoside hydrolase 15-related G6N00_RS17310 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein G6N00_RS17315 ENOG4108I5D sulfate abc transporter G6N00_RS17320 ENOG4105ECW sulfate abc transporter G6N00_RS17325 ENOG4108IJ6 ABC transporter G6N00_RS17335 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) G6N00_RS17365 ENOG4105F95 Monooxygenase G6N00_RS17440 ENOG4105C1G acyl-Coa dehydrogenase G6N00_RS17465 ENOG4105CHR reductase G6N00_RS17475 ENOG41060WC Enoyl-CoA hydratase G6N00_RS17480 ENOG4105E39 Enoyl-CoA hydratase G6N00_RS17485 ENOG4105E39 Enoyl-CoA hydratase G6N00_RS17490 ENOG4105FUY alpha subunit G6N00_RS17505 ENOG4105CHU acetyl-coa acetyltransferase G6N00_RS17515 ENOG4105CHU acetyl-coa acetyltransferase G6N00_RS17520 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr G6N00_RS17525 ENOG4105CEY Amp-dependent synthetase and ligase G6N00_RS17530 ENOG4105CEY Amp-dependent synthetase and ligase G6N00_RS17550 ENOG4105CEY Amp-dependent synthetase and ligase G6N00_RS17565 ENOG4105C26 Dehydrogenase G6N00_RS17580 ENOG4105CYC Transferase G6N00_RS17590 ENOG4105CHU acetyl-coa acetyltransferase G6N00_RS17595 ENOG410630P Transcriptional regulator G6N00_RS17650 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) G6N00_RS17655 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone G6N00_RS17660 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) G6N00_RS17665 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) G6N00_RS17685 ENOG4105CY3 ABC transporter, permease G6N00_RS17795 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) G6N00_RS17885 ENOG4105XEA Tetr family transcriptional regulator G6N00_RS17900 ENOG4105MKU Transcriptional regulator G6N00_RS17935 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) G6N00_RS17950 ENOG410719E cytochrome p450 G6N00_RS17965 ENOG4105CHR reductase G6N00_RS17970 ENOG41061TZ Short-chain dehydrogenase reductase Sdr G6N00_RS17995 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) G6N00_RS18010 ENOG4105CEY Amp-dependent synthetase and ligase G6N00_RS18030 ENOG4105CPQ Dehydrogenase G6N00_RS18045 ENOG4108R85 Short chain dehydrogenase G6N00_RS18085 ENOG4108KC2 acyl-Coa dehydrogenase G6N00_RS18100 ENOG4105X7H acyl-CoA dehydrogenase G6N00_RS18120 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G6N00_RS18150 ENOG4105D2B acyl-CoA dehydrogenase G6N00_RS18165 ENOG4105C1G acyl-Coa dehydrogenase G6N00_RS18170 ENOG4105CC9 acyl-Coa dehydrogenase G6N00_RS18175 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase G6N00_RS18185 ENOG4105CHR reductase G6N00_RS18210 ENOG4105E39 Enoyl-CoA hydratase G6N00_RS18220 ENOG4105D2B acyl-CoA dehydrogenase G6N00_RS18225 ENOG4105CGU Enoyl-CoA hydratase G6N00_RS18235 ENOG4105CGU Enoyl-CoA hydratase G6N00_RS18240 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr G6N00_RS18245 ENOG4105CEY Amp-dependent synthetase and ligase G6N00_RS18260 ENOG4105CNV Aldolase G6N00_RS18290 ENOG4105X7H acyl-CoA dehydrogenase G6N00_RS18295 ENOG4105C1G acyl-Coa dehydrogenase G6N00_RS18340 ENOG4105CEI nitrite reductase G6N00_RS18375 ENOG4105CXK mandelate racemase muconate lactonizing G6N00_RS18385 ENOG4107QM5 aconitate hydratase G6N00_RS18420 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) G6N00_RS18495 ENOG4107R1I NAD-dependent malic enzyme G6N00_RS18500 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) G6N00_RS18515 ENOG4107XI7 Tetr family transcriptional regulator G6N00_RS18525 ENOG4105CHR reductase G6N00_RS18535 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) G6N00_RS18540 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase G6N00_RS18545 ENOG4105C0W non-ribosomal peptide synthetase G6N00_RS18555 ENOG4107EEY synthase G6N00_RS18565 ENOG4105CEY Amp-dependent synthetase and ligase G6N00_RS18575 ENOG4107D0A Flavoprotein monooxygenase required for N-hydroxylation of the two acylated lysine residues during mycobactin assembly, thus producing the hydroxamate groups necessary for iron sequestration. Is also able, but less efficiently, to hydroxylate L-lysine (non acylated) in vitro G6N00_RS18595 ENOG4108KPJ rna polymerase sigma factor G6N00_RS18610 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) G6N00_RS18615 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) G6N00_RS18650 ENOG4105CXN decarboxylase G6N00_RS18660 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) G6N00_RS18685 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) G6N00_RS18735 ENOG4105DEN Luciferase family G6N00_RS18745 ENOG4105D7W serine acetyltransferase G6N00_RS18755 ENOG4107ZR7 Membrane G6N00_RS18825 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) G6N00_RS18830 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) G6N00_RS18845 ENOG4105IDI abc transporter atp-binding protein G6N00_RS18870 ENOG4105CUB amino acid G6N00_RS18975 ENOG4108MUZ hydrolase G6N00_RS19005 ENOG4105C26 Dehydrogenase G6N00_RS19025 ENOG4105F0K SARP family transcriptional regulator G6N00_RS19030 ENOG4108Q50 Histidine kinase G6N00_RS19055 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) G6N00_RS19075 ENOG4105CEY Amp-dependent synthetase and ligase G6N00_RS19120 ENOG4105CHU acetyl-coa acetyltransferase G6N00_RS19135 ENOG4107STQ Multicopper oxidase G6N00_RS19160 ENOG4105CPT Alpha beta hydrolase G6N00_RS19175 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) G6N00_RS19195 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) G6N00_RS19215 ENOG4106A3M Cytochrome p-450 G6N00_RS19250 ENOG4105FBW Monooxygenase G6N00_RS19270 ENOG4108MJN Glycosyl Transferase G6N00_RS19285 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) G6N00_RS19305 ENOG4108Z4U Ferredoxin G6N00_RS19320 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) G6N00_RS19340 ENOG41067SE Tetr family transcriptional regulator G6N00_RS19445 ENOG4105CEY Amp-dependent synthetase and ligase G6N00_RS19450 ENOG4105C26 Dehydrogenase G6N00_RS19460 ENOG41061TZ Short-chain dehydrogenase reductase Sdr G6N00_RS19475 ENOG4105KBX Transcriptional regulator, TetR family G6N00_RS19520 ENOG4106A3M Cytochrome p-450 G6N00_RS19545 ENOG4108KC1 acyl-Coa dehydrogenase G6N00_RS19550 ENOG4108RU2 n-acetylmuramoyl-l-alanine amidase G6N00_RS19565 ENOG4105F95 Monooxygenase G6N00_RS19735 ENOG4105CIR epoxide hydrolase G6N00_RS19745 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) G6N00_RS19905 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) G6N00_RS19940 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) G6N00_RS19950 ENOG4105CM2 brancheD-chain amino acid aminotransferase G6N00_RS19960 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) G6N00_RS19990 ENOG4107T4Z adenosine kinase G6N00_RS20000 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) G6N00_RS20005 ENOG4108ZRS Part of cytochrome c oxidase, its function is G6N00_RS20030 ENOG4107UDY cytochrome C G6N00_RS20035 ENOG4105CCU oxidase (Subunit III) G6N00_RS20040 ENOG4108I0Q anthranilate phosphoribosyltransferase G6N00_RS20070 ENOG4108IQE Amp-dependent synthetase and ligase G6N00_RS20085 ENOG4105D0U Arsenite-activated ATPase (ArsA) G6N00_RS20115 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase G6N00_RS20125 ENOG4105KYH transcriptional regulatory protein G6N00_RS20130 ENOG41090CE integral membrane protein G6N00_RS20145 ENOG4105R14 (LipO)protein G6N00_RS20175 ENOG4105CJN penicillin-binding protein G6N00_RS20200 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) G6N00_RS20215 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) G6N00_RS20230 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) G6N00_RS20275 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) G6N00_RS20285 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) G6N00_RS20320 ENOG4108RM3 Phosphatase with a broad specificity. Its primary physiological function is to dephosphorylate 3'-phosphoadenosine 5'-phosphate (PAP) and 3'-phosphoadenosine 5'-phosphosulfate (PAPS). Thus, plays a role in mycobacterial sulfur metabolism, since it can serve as a key regulator of the sulfate assimilation pathway by controlling the pools of PAP and PAPS in the cell. To a lesser extent, is also able to hydrolyze inositol 1-phosphate (I- 1-P), fructose 1,6-bisphosphate (FBP) (to fructose 6-phosphate (F- 6-P)) and AMP in vitro, but this might has no significance in vivo G6N00_RS20325 ENOG4105C8N cysteinyl-tRNA synthetase G6N00_RS20330 ENOG4108Q9V regulatoR G6N00_RS20365 ENOG4106A3M Cytochrome p-450 G6N00_RS20380 ENOG4107RCI amp-dependent synthetase and ligase G6N00_RS20385 ENOG4108BAS reductase G6N00_RS20400 ENOG4105C3R Methionine synthase G6N00_RS20455 ENOG41067SE Tetr family transcriptional regulator G6N00_RS20530 ENOG4105KPK Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) G6N00_RS20550 ENOG4107TMB Transcriptional regulator G6N00_RS20600 ENOG4108RG3 short-chain dehydrogenase reductase G6N00_RS20645 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component G6N00_RS20670 ENOG4105CTK cobaltochelatase, cobn subunit G6N00_RS20680 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) G6N00_RS20730 ENOG4108R85 Short chain dehydrogenase G6N00_RS20755 ENOG4105GMT ATPase associated with various cellular activities aaa_5 G6N00_RS20790 ENOG41076PI Short-chain dehydrogenase reductase Sdr G6N00_RS20815 ENOG4105EBR Carboxylesterase G6N00_RS20825 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family G6N00_RS20835 ENOG4108XW1 Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) G6N00_RS20860 ENOG4108RWI nicotinamidase G6N00_RS20875 ENOG4108KPJ rna polymerase sigma factor G6N00_RS20890 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component G6N00_RS20915 ENOG4105EKT )-iron permease G6N00_RS20920 ENOG410650H (LipO)protein G6N00_RS20925 ENOG4105DBE peroxidase G6N00_RS20935 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) G6N00_RS20965 ENOG4107SET aldo keto reductase G6N00_RS20975 ENOG4105CMR udp-glucose 4-epimerase G6N00_RS20995 ENOG4105D2B acyl-CoA dehydrogenase G6N00_RS21045 ENOG4105CKI cobalamin synthesis protein G6N00_RS21050 ENOG4105C29 acyl-CoA thioesterase G6N00_RS21085 ENOG4107Y32 Adenosine-deaminase (Editase) domain G6N00_RS21105 ENOG4108KPJ rna polymerase sigma factor G6N00_RS21195 ENOG4107RSM transcriptional regulator G6N00_RS21220 ENOG4108V1T peptidylprolyl cis-trans isomerase G6N00_RS21225 ENOG4105MXB limonene-12-epoxide hydrolase G6N00_RS21230 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr G6N00_RS21250 ENOG4105CI0 Citrate lyase G6N00_RS21270 ENOG4107SCK Monooxygenase G6N00_RS21275 ENOG4105CQ7 ATP-dependent helicase G6N00_RS21285 ENOG4105CGU Enoyl-CoA hydratase G6N00_RS21305 ENOG4105E2A Dehydrogenase G6N00_RS21360 ENOG4107UBC ErfK ybiS ycfS ynhG family protein G6N00_RS21375 ENOG4108WKN secreted protein G6N00_RS21380 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) G6N00_RS21385 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) G6N00_RS21435 ENOG4108XW1 Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) G6N00_RS21440 ENOG4105C26 Dehydrogenase G6N00_RS21470 ENOG4105EA8 2-Nitropropane dioxygenase G6N00_RS21505 ENOG4105CHR reductase G6N00_RS21550 ENOG4105MHT Transcriptional regulator, ARSR family G6N00_RS21570 ENOG4105EWK phytoene G6N00_RS21580 ENOG41090U3 tautomerase G6N00_RS21585 ENOG4107QWG 2-Nitropropane dioxygenase G6N00_RS21610 ENOG41082T9 Membrane G6N00_RS21625 ENOG4107RGD Major Facilitator superfamily G6N00_RS21655 ENOG4105E2A Dehydrogenase G6N00_RS21725 ENOG4105CHR reductase G6N00_RS21750 ENOG4105C5F glutamine synthetase G6N00_RS21760 ENOG4107ZN8 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) G6N00_RS21770 ENOG4108UQY Iron-storage protein G6N00_RS21780 ENOG4108UKI Enoyl-CoA hydratase G6N00_RS21795 ENOG4105C5Q Transcriptional regulator G6N00_RS21805 ENOG4108X7C Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) G6N00_RS21825 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) G6N00_RS21870 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) G6N00_RS21875 ENOG4105EMU Dehydrogenase G6N00_RS21940 ENOG4105CEP NADH dehydrogenase G6N00_RS21965 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) G6N00_RS21980 ENOG4107RCI amp-dependent synthetase and ligase G6N00_RS21985 ENOG4107Q3C acyl-Coa dehydrogenase G6N00_RS21995 ENOG4105C37 (CBS) domain G6N00_RS22000 ENOG4107UAX integral membrane protein G6N00_RS22095 ENOG4107EFR Flavocytochrome c G6N00_RS22320 ENOG41076PI Short-chain dehydrogenase reductase Sdr G6N00_RS22325 ENOG4107RUY (E1 component), alpha subunit G6N00_RS22330 ENOG4105CPP Dehydrogenase, E1 component G6N00_RS22345 ENOG4105CEY Amp-dependent synthetase and ligase G6N00_RS22350 ENOG4105FUY alpha subunit G6N00_RS22355 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein G6N00_RS22360 ENOG4105E39 Enoyl-CoA hydratase G6N00_RS22385 ENOG4105C1J atp-dependent rna helicase G6N00_RS22390 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) G6N00_RS22485 ENOG4105EMU Dehydrogenase G6N00_RS22495 ENOG4108IPT Naphthoate synthase G6N00_RS22500 ENOG41076PI Short-chain dehydrogenase reductase Sdr G6N00_RS22535 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) G6N00_RS22565 ENOG4105CEY Amp-dependent synthetase and ligase G6N00_RS22595 ENOG4105J5T Amp-dependent synthetase and ligase G6N00_RS22600 ENOG4107S2E monooxygenase G6N00_RS22620 ENOG410900P UPF0336 protein G6N00_RS22625 ENOG4105D2B acyl-CoA dehydrogenase G6N00_RS22630 ENOG4105X7H acyl-CoA dehydrogenase G6N00_RS22635 ENOG4105IDI abc transporter atp-binding protein G6N00_RS22645 ENOG4105CHR reductase G6N00_RS22650 ENOG4107QY8 reductase G6N00_RS22670 ENOG41088PD hydrolase G6N00_RS22695 ENOG4107S2E monooxygenase G6N00_RS22710 ENOG4105H37 Glyoxalase Bleomycin resistance protein (Dioxygenase G6N00_RS22730 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase G6N00_RS22745 ENOG4105H9W Short-chain dehydrogenase reductase Sdr G6N00_RS22755 ENOG4105CEY Amp-dependent synthetase and ligase G6N00_RS22760 ENOG4105D2B acyl-CoA dehydrogenase G6N00_RS22790 ENOG4108R85 Short chain dehydrogenase G6N00_RS22795 ENOG4105CHR reductase G6N00_RS22810 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein G6N00_RS22865 ENOG4105C54 Major Facilitator superfamily G6N00_RS22870 ENOG4108DIG cyanophycin synthetase G6N00_RS22910 ENOG4105VEQ Cold shock protein G6N00_RS23010 ENOG4105C1G acyl-Coa dehydrogenase G6N00_RS23040 ENOG4105D2B acyl-CoA dehydrogenase G6N00_RS23045 ENOG4108DBC nitroreductase G6N00_RS23065 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) G6N00_RS23095 ENOG41076PI Short-chain dehydrogenase reductase Sdr G6N00_RS23105 ENOG4105C1G acyl-Coa dehydrogenase G6N00_RS23165 ENOG4108RWI nicotinamidase G6N00_RS23180 ENOG4105CGU Enoyl-CoA hydratase G6N00_RS23190 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr G6N00_RS23205 ENOG4105CCU oxidase (Subunit III) G6N00_RS23245 ENOG4105C26 Dehydrogenase G6N00_RS23280 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G6N00_RS23295 ENOG4105CEY Amp-dependent synthetase and ligase G6N00_RS23300 ENOG4105CHU acetyl-coa acetyltransferase G6N00_RS23305 ENOG4105D2B acyl-CoA dehydrogenase G6N00_RS23310 ENOG4105CC9 acyl-Coa dehydrogenase G6N00_RS23335 ENOG4105D7V transposase G6N00_RS23355 ENOG4105FUY alpha subunit G6N00_RS23365 ENOG4105CEY Amp-dependent synthetase and ligase G6N00_RS23375 ENOG4105C26 Dehydrogenase G6N00_RS23380 ENOG4105C1G acyl-Coa dehydrogenase G6N00_RS23385 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G6N00_RS23390 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G6N00_RS23410 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) G6N00_RS23415 ENOG4105C1G acyl-Coa dehydrogenase G6N00_RS23420 ENOG41060WC Enoyl-CoA hydratase G6N00_RS23440 ENOG4105CGU Enoyl-CoA hydratase G6N00_RS23445 ENOG4105C1G acyl-Coa dehydrogenase G6N00_RS23460 ENOG4106YT9 Enoyl-CoA hydratase G6N00_RS23465 ENOG4105CEY Amp-dependent synthetase and ligase G6N00_RS23470 ENOG4105D2B acyl-CoA dehydrogenase G6N00_RS23475 ENOG4105CC9 acyl-Coa dehydrogenase G6N00_RS23480 ENOG4105CC9 acyl-Coa dehydrogenase G6N00_RS23500 ENOG410719E cytochrome p450 G6N00_RS23515 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase G6N00_RS23520 ENOG4108XG4 DNA-binding transcriptional regulator G6N00_RS23545 ENOG41062JF Transcriptional regulator G6N00_RS23565 ENOG4105CHU acetyl-coa acetyltransferase G6N00_RS23610 ENOG4108J5G 6-phosphogluconate dehydrogenase G6N00_RS23620 ENOG4106YKD Cytochrome p-450 G6N00_RS23635 ENOG4105CEY Amp-dependent synthetase and ligase G6N00_RS23650 ENOG4105CEY Amp-dependent synthetase and ligase G6N00_RS23655 ENOG4105D2B acyl-CoA dehydrogenase G6N00_RS23670 ENOG4105CC9 acyl-Coa dehydrogenase G6N00_RS23675 ENOG4105CYC Transferase G6N00_RS23680 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr G6N00_RS23700 ENOG4105C26 Dehydrogenase G6N00_RS23705 ENOG4105CC9 acyl-Coa dehydrogenase G6N00_RS23715 ENOG4105C1G acyl-Coa dehydrogenase G6N00_RS23740 ENOG4105E39 Enoyl-CoA hydratase G6N00_RS23755 ENOG41061TZ Short-chain dehydrogenase reductase Sdr G6N00_RS23760 ENOG4105D2B acyl-CoA dehydrogenase G6N00_RS23765 ENOG4105C1G acyl-Coa dehydrogenase G6N00_RS23770 ENOG41061TZ Short-chain dehydrogenase reductase Sdr G6N00_RS23775 ENOG4105E39 Enoyl-CoA hydratase G6N00_RS23785 ENOG4105CHR reductase G6N00_RS23820 ENOG41073TP transcriptional regulator G6N00_RS23825 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G6N00_RS23880 ENOG4108R86 Transcriptional regulator G6N00_RS23970 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) G6N00_RS24020 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) G6N00_RS24035 ENOG4105DSU hydrolase G6N00_RS24050 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) G6N00_RS24055 ENOG4108VX5 3-methyladenine DNA glycosylase G6N00_RS24065 ENOG4105CJ1 ABC, transporter G6N00_RS24080 ENOG4108RZE Tetr family transcriptional regulator G6N00_RS24085 ENOG4105W49 UPF0434 protein G6N00_RS24115 ENOG4108W6C Dehydrogenase G6N00_RS24120 ENOG4105DIA mandelate racemase muconate lactonizing G6N00_RS24130 ENOG4105C5H ABC transporter G6N00_RS24145 ENOG4108JA1 polyketide synthase G6N00_RS24145 ENOG4108JA1 polyketide synthase G6N00_RS24150 ENOG4108JA1 polyketide synthase G6N00_RS24155 ENOG4108JA1 polyketide synthase G6N00_RS24165 ENOG4105CH7 arginosuccinase G6N00_RS24180 ENOG4105DBV ornithine carbamoyltransferase G6N00_RS24195 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) G6N00_RS24200 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase G6N00_RS24205 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) G6N00_RS24210 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) G6N00_RS24240 ENOG41084BS 50S ribosomal protein L35 G6N00_RS24265 ENOG4108RZE Tetr family transcriptional regulator G6N00_RS24275 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) G6N00_RS24310 ENOG4105C5X domain protein G6N00_RS24340 ENOG4105IDI abc transporter atp-binding protein G6N00_RS24350 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) G6N00_RS24355 ENOG4105DQE DNA ligase G6N00_RS24365 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) G6N00_RS24375 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) G6N00_RS24435 ENOG4105C4M (Ubiquinol oxidase) subunit I G6N00_RS24440 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii G6N00_RS24445 ENOG4108JJ9 ABC, transporter G6N00_RS24450 ENOG4108JJA ABC, transporter G6N00_RS24465 ENOG4105C29 acyl-CoA thioesterase G6N00_RS24505 ENOG4105CRQ synthase (Component I) G6N00_RS24520 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase G6N00_RS24530 ENOG4108MWI inositol mono-phosphatase G6N00_RS24540 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) G6N00_RS24565 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase G6N00_RS24625 ENOG4105BZU Histidine kinase G6N00_RS24630 ENOG4105D8X mechanosensitive ion channel G6N00_RS24655 ENOG4107QNE Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) G6N00_RS24665 ENOG4105ZXU NLP P60 protein G6N00_RS24690 ENOG4105CSW GntR family transcriptional regulator G6N00_RS24700 ENOG410841Q phosphoesterase PA-phosphatase related protein G6N00_RS24755 ENOG4108W6C Dehydrogenase G6N00_RS24765 ENOG4105K6B K06886 hemoglobin G6N00_RS24785 ENOG4105HDK L-asparaginase G6N00_RS24795 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) G6N00_RS24875 ENOG4105C30 Nad-dependent epimerase dehydratase G6N00_RS24880 ENOG4105C0K Gdp-mannose 4,6-dehydratase G6N00_RS24890 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase G6N00_RS24895 ENOG4105FAW cDP-glucose 4,6-dehydratase G6N00_RS24910 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase G6N00_RS24915 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) G6N00_RS24925 ENOG4105K64 Glycosyl transferase, family 2 G6N00_RS24940 ENOG4105C0K Gdp-mannose 4,6-dehydratase G6N00_RS24945 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) G6N00_RS24955 ENOG4105EMU Dehydrogenase G6N00_RS25050 ENOG4106F60 Histidine kinase G6N00_RS25055 ENOG4108RQS Two component transcriptional regulator (Winged helix family G6N00_RS25090 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) G6N00_RS25095 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH G6N00_RS25100 ENOG4105CHR reductase G6N00_RS25110 ENOG4107QVM von Willebrand factor, type A G6N00_RS25120 ENOG4105C7R Atpase associated with various cellular activities aaa_3 G6N00_RS25140 ENOG4107QM5 aconitate hydratase G6N00_RS25145 ENOG4108Q5F Tetr family transcriptional regulator G6N00_RS25155 ENOG4105C5H ABC transporter G6N00_RS25165 ENOG41080RH Thioredoxin G6N00_RS25170 ENOG4105CSU acyl-Coa dehydrogenase G6N00_RS25200 ENOG4108UQ8 endoribonuclease L-psp G6N00_RS25220 ENOG4105CHU acetyl-coa acetyltransferase G6N00_RS25225 ENOG4105CHR reductase G6N00_RS25270 ENOG4105DC8 reductase G6N00_RS25320 ENOG4107ZHV Transcriptional regulator G6N00_RS25385 ENOG4105CHR reductase G6N00_RS25405 ENOG4105C3M thioredoxin reductase G6N00_RS25415 ENOG4105VG1 fes assembly suf system protein G6N00_RS25420 ENOG4108UNV SUF system FeS assembly protein, NifU family G6N00_RS25430 ENOG4105C3K feS assembly ATPase SufC G6N00_RS25450 ENOG4107JC6 Membrane G6N00_RS25475 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein G6N00_RS25490 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) G6N00_RS25520 ENOG4108FN7 Aldo keto reductase G6N00_RS25525 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) G6N00_RS25545 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase G6N00_RS25585 ENOG4105CEY Amp-dependent synthetase and ligase G6N00_RS25615 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) G6N00_RS25620 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) G6N00_RS25645 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) G6N00_RS25660 ENOG41064B9 (LipO)protein G6N00_RS25715 ENOG4107RN6 Monooxygenase G6N00_RS25740 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) G6N00_RS25750 ENOG4105F4R Transcriptional regulator mode G6N00_RS25765 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain G6N00_RS25785 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) G6N00_RS25795 ENOG4105D9U N-acetyltransferase G6N00_RS25825 ENOG41080U6 GntR family transcriptional regulator G6N00_RS25830 ENOG4105CXN decarboxylase G6N00_RS25870 ENOG4105D49 3-dehydroquinate synthase G6N00_RS25900 ENOG4105E2X shikimate dehydrogenase G6N00_RS25905 ENOG4105HHA aminodeoxychorismate lyase G6N00_RS25910 ENOG41080G3 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) G6N00_RS25920 ENOG4107ZED Uncharacterised protein family UPF0047 G6N00_RS26010 ENOG4107W7X Aldolase G6N00_RS26060 ENOG4107VMB Beta-lactamase domain protein