locus-tag	class	description
W7S_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
W7S_RS00010	COG0592	DNA-directed DNA polymerase activity
W7S_RS00020	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
W7S_RS00025	COG0187	DNA topoisomerase II activity
W7S_RS00065	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
W7S_RS00095	COG0515	serine threonine protein kinase
W7S_RS00120	COG1716	ATPase activity
W7S_RS00150	COG0318	PFAM AMP-dependent synthetase and ligase
W7S_RS00180	COG1960	acyl-CoA dehydrogenase activity
W7S_RS00255	COG0495	leucyl-tRNA aminoacylation
W7S_RS00270	COG1126	abc transporter atp-binding protein
W7S_RS00275	COG0765	amino acid transport
W7S_RS00285	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
W7S_RS00300	COG1309	transcriptional regulator
W7S_RS00305	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
W7S_RS00305	COG0596	Alpha beta hydrolase
W7S_RS00350	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
W7S_RS00365	COG0360	Binds together with S18 to 16S ribosomal RNA
W7S_RS00390	COG1309	transcriptional regulator
W7S_RS00405	COG1278	Cold shock
W7S_RS00415	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
W7S_RS00425	COG1028	Short-chain dehydrogenase reductase Sdr
W7S_RS00440	COG1028	Short-chain dehydrogenase reductase Sdr
W7S_RS00465	COG1028	Short-chain dehydrogenase reductase Sdr
W7S_RS00470	COG0277	FAD linked oxidase domain protein
W7S_RS00480	COG2267	carboxylic ester hydrolase activity
W7S_RS00485	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
W7S_RS00495	COG1247	-acetyltransferase
W7S_RS00520	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
W7S_RS00565	COG1309	transcriptional regulator
W7S_RS00620	COG0659	secondary active sulfate transmembrane transporter activity
W7S_RS00630	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
W7S_RS00640	COG2124	cytochrome p450
W7S_RS00650	COG0714	Associated with various cellular activities
W7S_RS00670	COG0477	Major facilitator Superfamily
W7S_RS00690	COG0346	lactoylglutathione lyase activity
W7S_RS00730	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
W7S_RS00750	COG4552	Acetyltransferase involved in intracellular survival and related
W7S_RS00755	COG1960	acyl-CoA dehydrogenase activity
W7S_RS00760	COG1309	transcriptional regulator
W7S_RS00775	COG5651	PPE family
W7S_RS00805	COG1404	Belongs to the peptidase S8 family
W7S_RS00825	COG0702	epimerase
W7S_RS00840	COG0069	glutamate synthase activity
W7S_RS00840	COG0070	glutamate synthase
W7S_RS00840	COG0067	glutamate synthase
W7S_RS00860	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
W7S_RS00860	COG1796	DNA polymerase
W7S_RS00870	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
W7S_RS00880	COG2072	flavoprotein involved in K transport
W7S_RS00925	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
W7S_RS00940	COG1316	TRANSCRIPTIONal
W7S_RS01030	COG0561	phosphatase activity
W7S_RS01050	COG1216	Glycosyl transferase, family 2
W7S_RS01065	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
W7S_RS01075	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
W7S_RS01080	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
W7S_RS01085	COG0318	PFAM AMP-dependent synthetase and ligase
W7S_RS01090	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
W7S_RS01090	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
W7S_RS01090	COG3321	synthase
W7S_RS01095	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
W7S_RS01100	COG1960	acyl-CoA dehydrogenase activity
W7S_RS01140	COG0640	Transcriptional regulator
W7S_RS01155	COG1028	Short-chain dehydrogenase reductase Sdr
W7S_RS01160	COG0277	FAD linked oxidase domain protein
W7S_RS01175	COG1403	HNH endonuclease
W7S_RS01210	COG0604	alcohol dehydrogenase
W7S_RS01230	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
W7S_RS01250	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
W7S_RS01265	COG2801	Transposase and inactivated derivatives
W7S_RS01265	COG3415	Transposase
W7S_RS01295	COG0745	RESPONSE REGULATOR receiver
W7S_RS01300	COG2205	protein histidine kinase activity
W7S_RS01355	COG5416	Lipopolysaccharide assembly protein A domain
W7S_RS01370	COG1174	glycine betaine transport
W7S_RS01385	COG0287	Prephenate dehydrogenase
W7S_RS01395	COG0590	tRNA wobble adenosine to inosine editing
W7S_RS01415	COG1511	domain protein
W7S_RS01460	COG1804	L-carnitine dehydratase bile acid-inducible protein F
W7S_RS01465	COG2301	Belongs to the HpcH HpaI aldolase family
W7S_RS01470	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
W7S_RS01480	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
W7S_RS01490	COG1396	sequence-specific DNA binding
W7S_RS01490	COG3800	Transcriptional regulator
W7S_RS01495	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
W7S_RS01500	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
W7S_RS01520	COG3804	dihydrodipicolinate reductase
W7S_RS01540	COG0596	Alpha beta hydrolase
W7S_RS01545	COG2124	cytochrome p450
W7S_RS01560	COG3328	transposase activity
W7S_RS01570	COG1793	dna ligase
W7S_RS01585	COG1335	isochorismatase
W7S_RS01620	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
W7S_RS01640	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
W7S_RS01650	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
W7S_RS01665	COG0860	N-Acetylmuramoyl-L-alanine amidase
W7S_RS01670	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
W7S_RS01690	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
W7S_RS01695	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
W7S_RS01700	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
W7S_RS01740	COG1262	PFAM Formylglycine-generating sulfatase enzyme
W7S_RS01745	COG0121	glutamine amidotransferase
W7S_RS01755	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
W7S_RS01770	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
W7S_RS01775	COG1695	Transcriptional regulator
W7S_RS01800	COG0714	Associated with various cellular activities
W7S_RS01825	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
W7S_RS01835	COG0693	protein deglycase activity
W7S_RS01840	COG2890	protein-(glutamine-N5) methyltransferase activity
W7S_RS01860	COG2172	sigma factor antagonist activity
W7S_RS01865	COG1366	Belongs to the anti-sigma-factor antagonist family
W7S_RS01870	COG1366	Belongs to the anti-sigma-factor antagonist family
W7S_RS01885	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
W7S_RS01910	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
W7S_RS01915	COG1408	metallophosphoesterase
W7S_RS01945	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
W7S_RS01960	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
W7S_RS01970	COG0494	nUDIX hydrolase
W7S_RS01995	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
W7S_RS02015	COG0601	transmembrane transport
W7S_RS02020	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
W7S_RS02080	COG1205	dead DEAH box helicase
W7S_RS02080	COG1111	helicase
W7S_RS02105	COG0470	DNA polymerase III
W7S_RS02150	COG2027	D-alanyl-D-alanine carboxypeptidase
W7S_RS02160	COG0037	tRNA processing
W7S_RS02180	COG0657	acetylesterase activity
W7S_RS02190	COG1403	HNH endonuclease
W7S_RS02195	COG2801	Transposase and inactivated derivatives
W7S_RS02200	COG1063	alcohol dehydrogenase
W7S_RS02225	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
W7S_RS02230	COG0302	gtp cyclohydrolase
W7S_RS02235	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
W7S_RS02240	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
W7S_RS02265	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
W7S_RS02345	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
W7S_RS02380	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
W7S_RS02390	COG1108	ABC-type Mn2 Zn2 transport systems permease components
W7S_RS02395	COG1121	(ABC) transporter
W7S_RS02405	COG1609	Transcriptional regulator
W7S_RS02410	COG1309	transcriptional regulator
W7S_RS02415	COG1960	acyl-CoA dehydrogenase activity
W7S_RS02465	COG0436	Aminotransferase
W7S_RS02470	COG1960	acyl-CoA dehydrogenase activity
W7S_RS02475	COG1960	acyl-CoA dehydrogenase activity
W7S_RS02480	COG1960	acyl-CoA dehydrogenase activity
W7S_RS02485	COG0318	PFAM AMP-dependent synthetase and ligase
W7S_RS02490	COG1960	acyl-CoA dehydrogenase activity
W7S_RS02505	COG0183	Belongs to the thiolase family
W7S_RS02540	COG1024	Enoyl-CoA hydratase
W7S_RS02545	COG1028	Short-chain dehydrogenase reductase Sdr
W7S_RS02550	COG1028	Short-chain dehydrogenase reductase Sdr
W7S_RS02570	COG0183	Belongs to the thiolase family
W7S_RS02575	COG2124	cytochrome p450
W7S_RS02580	COG1960	acyl-CoA dehydrogenase activity
W7S_RS02585	COG1960	acyl-CoA dehydrogenase activity
W7S_RS02590	COG2030	dehydratase
W7S_RS02610	COG2030	dehydratase
W7S_RS02615	COG1053	succinate dehydrogenase
W7S_RS02620	COG3971	2-oxopent-4-enoate hydratase activity
W7S_RS02625	COG4569	acetaldehyde dehydrogenase (acetylating) activity
W7S_RS02630	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
W7S_RS02645	COG1028	Short-chain dehydrogenase reductase Sdr
W7S_RS02660	COG4638	Rieske (2fe-2S)
W7S_RS02690	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
W7S_RS02700	COG2124	cytochrome p450
W7S_RS02720	COG3001	Fructosamine kinase
W7S_RS02730	COG0028	Belongs to the TPP enzyme family
W7S_RS02745	COG0318	PFAM AMP-dependent synthetase and ligase
W7S_RS02750	COG1960	acyl-CoA dehydrogenase activity
W7S_RS02755	COG1960	acyl-CoA dehydrogenase activity
W7S_RS02765	COG1028	Short-chain dehydrogenase reductase Sdr
W7S_RS02770	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
W7S_RS02775	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
W7S_RS02800	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
W7S_RS02830	COG1024	Enoyl-CoA hydratase
W7S_RS02845	COG1316	TRANSCRIPTIONal
W7S_RS02915	COG0745	RESPONSE REGULATOR receiver
W7S_RS02920	COG2205	protein histidine kinase activity
W7S_RS02950	COG2124	cytochrome p450
W7S_RS02955	COG4221	oxidoreductase activity
W7S_RS02990	COG1716	ATPase activity
W7S_RS03020	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
W7S_RS03040	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
W7S_RS03050	COG0477	Major facilitator Superfamily
W7S_RS03055	COG0477	Major facilitator Superfamily
W7S_RS03070	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
W7S_RS03080	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
W7S_RS03085	COG0047	phosphoribosylformylglycinamidine synthase activity
W7S_RS03095	COG0204	Acyl-transferase
W7S_RS03115	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
W7S_RS03155	COG1017	nitric oxide dioxygenase activity
W7S_RS03155	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
W7S_RS03165	COG2837	iron assimilation
W7S_RS03215	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
W7S_RS03235	COG4044	May play a role in the intracellular transport of hydrophobic ligands
W7S_RS03270	COG0745	RESPONSE REGULATOR receiver
W7S_RS03295	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
W7S_RS03335	COG0640	Transcriptional regulator
W7S_RS03340	COG0590	tRNA wobble adenosine to inosine editing
W7S_RS03370	COG4974	Belongs to the 'phage' integrase family
W7S_RS03390	COG1609	Transcriptional regulator
W7S_RS03440	COG1028	Short-chain dehydrogenase reductase Sdr
W7S_RS03455	COG2124	cytochrome p450
W7S_RS03460	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
W7S_RS03465	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
W7S_RS03485	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
W7S_RS03485	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
W7S_RS03490	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
W7S_RS03495	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
W7S_RS03500	COG1804	L-carnitine dehydratase bile acid-inducible protein F
W7S_RS03535	COG1960	acyl-CoA dehydrogenase activity
W7S_RS03540	COG1960	acyl-CoA dehydrogenase activity
W7S_RS03555	COG3479	Phenolic acid decarboxylase
W7S_RS03565	COG1703	isobutyryl-CoA mutase activity
W7S_RS03570	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
W7S_RS03580	COG4585	Histidine kinase
W7S_RS03590	COG1053	succinate dehydrogenase
W7S_RS03600	COG2267	carboxylic ester hydrolase activity
W7S_RS03605	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
W7S_RS03610	COG3384	dioxygenase
W7S_RS03615	COG1053	succinate dehydrogenase
W7S_RS03625	COG1028	Short-chain dehydrogenase reductase Sdr
W7S_RS03640	COG2132	Multicopper oxidase
W7S_RS03655	COG2197	response regulator
W7S_RS03660	COG1028	Short-chain dehydrogenase reductase Sdr
W7S_RS03715	COG1024	Enoyl-CoA hydratase
W7S_RS03720	COG1804	L-carnitine dehydratase bile acid-inducible protein F
W7S_RS03725	COG1028	Short-chain dehydrogenase reductase Sdr
W7S_RS03735	COG1028	Short-chain dehydrogenase reductase Sdr
W7S_RS03745	COG1960	acyl-CoA dehydrogenase activity
W7S_RS03760	COG1960	acyl-CoA dehydrogenase activity
W7S_RS03770	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
W7S_RS03780	COG4638	Rieske (2fe-2S)
W7S_RS03800	COG1024	Enoyl-CoA hydratase
W7S_RS03805	COG0183	Belongs to the thiolase family
W7S_RS03810	COG1309	transcriptional regulator
W7S_RS03840	COG2124	cytochrome p450
W7S_RS03845	COG2084	Dehydrogenase
W7S_RS03885	COG1960	acyl-CoA dehydrogenase activity
W7S_RS03895	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
W7S_RS03975	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
W7S_RS03975	COG0778	Nitroreductase
W7S_RS03980	COG1960	acyl-CoA dehydrogenase activity
W7S_RS03985	COG1960	acyl-CoA dehydrogenase activity
W7S_RS04025	COG1804	L-carnitine dehydratase bile acid-inducible protein F
W7S_RS04030	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
W7S_RS04035	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
W7S_RS04060	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
W7S_RS04145	COG0318	PFAM AMP-dependent synthetase and ligase
W7S_RS04170	COG1804	L-carnitine dehydratase bile acid-inducible protein F
W7S_RS04190	COG0183	Belongs to the thiolase family
W7S_RS04195	COG1250	3-hydroxyacyl-CoA dehydrogenase
W7S_RS04195	COG1024	Enoyl-CoA hydratase
W7S_RS04200	COG2813	Specifically methylates the guanine in position
W7S_RS04220	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
W7S_RS04250	COG1061	Type III restriction enzyme res subunit
W7S_RS04290	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
W7S_RS04295	COG3304	Inner membrane component domain
W7S_RS04300	COG1278	Cold shock
W7S_RS04310	COG0435	Glutathione S-transferase
W7S_RS04325	COG2814	Major facilitator Superfamily
W7S_RS04365	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
W7S_RS04390	COG0259	pyridoxamine-phosphate oxidase activity
W7S_RS04530	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
W7S_RS04570	COG0581	inorganic phosphate transmembrane transporter activity
W7S_RS04580	COG2826	transposase and inactivated derivatives, IS30 family
W7S_RS04590	COG2801	Transposase and inactivated derivatives
W7S_RS04610	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
W7S_RS04645	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
W7S_RS04675	COG4942	peptidase
W7S_RS04715	COG0138	bifunctional purine biosynthesis protein purh
W7S_RS04735	COG0656	L-ascorbic acid biosynthetic process
W7S_RS04745	COG1024	Enoyl-CoA hydratase
W7S_RS04760	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
W7S_RS04765	COG1960	acyl-CoA dehydrogenase activity
W7S_RS04790	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
W7S_RS04795	COG0521	Mo-molybdopterin cofactor biosynthetic process
W7S_RS04795	COG0315	cyclic pyranopterin monophosphate synthase activity
W7S_RS04800	COG1970	mechanosensitive ion channel activity
W7S_RS04815	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
W7S_RS04820	COG1210	Utp--glucose-1-phosphate uridylyltransferase
W7S_RS04875	COG3328	transposase activity
W7S_RS04880	COG4584	PFAM Integrase catalytic
W7S_RS04885	COG1484	DNA-dependent DNA replication
W7S_RS04915	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
W7S_RS04955	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
W7S_RS04960	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
W7S_RS04965	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
W7S_RS04965	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
W7S_RS05000	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
W7S_RS05010	COG1252	NADH dehydrogenase
W7S_RS05045	COG0297	glycogen (starch) synthase activity
W7S_RS05045	COG0438	transferase activity, transferring glycosyl groups
W7S_RS05085	COG0297	glycogen (starch) synthase activity
W7S_RS05100	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
W7S_RS05150	COG0084	hydrolase, TatD family'
W7S_RS05165	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
W7S_RS05170	COG0318	PFAM AMP-dependent synthetase and ligase
W7S_RS05175	COG0193	aminoacyl-tRNA hydrolase activity
W7S_RS05180	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
W7S_RS05225	COG1309	transcriptional regulator
W7S_RS05240	COG3956	TIGRFAM MazG family protein
W7S_RS05285	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
W7S_RS05290	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
W7S_RS05310	COG2205	protein histidine kinase activity
W7S_RS05315	COG0745	RESPONSE REGULATOR receiver
W7S_RS05365	COG3391	amine dehydrogenase activity
W7S_RS05370	COG0318	PFAM AMP-dependent synthetase and ligase
W7S_RS05380	COG0121	glutamine amidotransferase
W7S_RS05425	COG1024	Enoyl-CoA hydratase
W7S_RS05435	COG0183	Belongs to the thiolase family
W7S_RS05440	COG2755	lipolytic protein G-D-S-L family
W7S_RS05445	COG0657	acetylesterase activity
W7S_RS05485	COG1331	Highly conserved protein containing a thioredoxin domain
W7S_RS05500	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
W7S_RS05510	COG0572	uridine kinase
W7S_RS05525	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
W7S_RS05575	COG2272	Belongs to the type-B carboxylesterase lipase family
W7S_RS05590	COG1570	exodeoxyribonuclease VII activity
W7S_RS05600	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
W7S_RS05610	COG0012	GTP binding
W7S_RS05615	COG2161	toxin-antitoxin pair type II binding
W7S_RS05645	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
W7S_RS05665	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
W7S_RS05695	COG0574	Belongs to the PEP-utilizing enzyme family
W7S_RS05695	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
W7S_RS05725	COG2826	transposase and inactivated derivatives, IS30 family
W7S_RS05730	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
W7S_RS05735	COG0702	epimerase
W7S_RS05745	COG1309	transcriptional regulator
W7S_RS05755	COG1960	acyl-CoA dehydrogenase activity
W7S_RS05760	COG1960	acyl-CoA dehydrogenase activity
W7S_RS05770	COG1028	Short-chain dehydrogenase reductase Sdr
W7S_RS05795	COG1028	Short-chain dehydrogenase reductase Sdr
W7S_RS05800	COG2124	cytochrome p450
W7S_RS05805	COG1012	belongs to the aldehyde dehydrogenase family
W7S_RS05810	COG0183	Belongs to the thiolase family
W7S_RS05815	COG1024	Enoyl-CoA hydratase
W7S_RS05825	COG1755	Isoprenylcysteine carboxyl methyltransferase
W7S_RS05835	COG0702	epimerase
W7S_RS05845	COG0702	epimerase
W7S_RS05850	COG1024	Enoyl-CoA hydratase
W7S_RS05855	COG1804	L-carnitine dehydratase bile acid-inducible protein F
W7S_RS05865	COG2409	Drug exporters of the RND superfamily
W7S_RS05875	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
W7S_RS05890	COG3467	pyridoxamine 5'-phosphate
W7S_RS05945	COG1140	nitrate reductase beta subunit
W7S_RS05960	COG1217	gtp-binding protein TYPA
W7S_RS05975	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
W7S_RS05985	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
W7S_RS06000	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
W7S_RS06010	COG0531	amino acid
W7S_RS06015	COG1028	Short-chain dehydrogenase reductase Sdr
W7S_RS06015	COG0604	alcohol dehydrogenase
W7S_RS06015	COG3321	synthase
W7S_RS06030	COG0529	Catalyzes the synthesis of activated sulfate
W7S_RS06035	COG2046	Belongs to the sulfate adenylyltransferase family
W7S_RS06050	COG0318	PFAM AMP-dependent synthetase and ligase
W7S_RS06065	COG1012	belongs to the aldehyde dehydrogenase family
W7S_RS06075	COG1309	transcriptional regulator
W7S_RS06110	COG0318	PFAM AMP-dependent synthetase and ligase
W7S_RS06115	COG0477	Major facilitator Superfamily
W7S_RS06145	COG1611	Belongs to the LOG family
W7S_RS06150	COG0318	PFAM AMP-dependent synthetase and ligase
W7S_RS06160	COG0463	Glycosyl transferase, family 2
W7S_RS06170	COG0519	Catalyzes the synthesis of GMP from XMP
W7S_RS06180	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
W7S_RS06190	COG3559	Exporter of polyketide antibiotics
W7S_RS06195	COG1131	(ABC) transporter
W7S_RS06200	COG1309	transcriptional regulator
W7S_RS06215	COG5662	AntiSigma factor
W7S_RS06220	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
W7S_RS06245	COG2239	Acts as a magnesium transporter
W7S_RS06290	COG0598	Magnesium transport protein CorA
W7S_RS06295	COG0039	L-malate dehydrogenase activity
W7S_RS06320	COG0567	Dehydrogenase, E1 component
W7S_RS06320	COG0508	dehydrogenase complex catalyzes the overall conversion of
W7S_RS06365	COG0277	FAD linked oxidase domain protein
W7S_RS06380	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
W7S_RS06530	COG3631	Ketosteroid isomerase-related protein
W7S_RS06535	COG0494	nUDIX hydrolase
W7S_RS06560	COG0018	arginyl-trna synthetase
W7S_RS06565	COG0019	diaminopimelate decarboxylase activity
W7S_RS06570	COG0460	homoserine dehydrogenase
W7S_RS06580	COG0083	homoserine kinase activity
W7S_RS06585	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
W7S_RS06600	COG2890	protein-(glutamine-N5) methyltransferase activity
W7S_RS06620	COG0356	it plays a direct role in the translocation of protons across the membrane
W7S_RS06625	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
W7S_RS06635	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
W7S_RS06635	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
W7S_RS06670	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
W7S_RS06690	COG5651	PPE family
W7S_RS06725	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
W7S_RS06745	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
W7S_RS06765	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
W7S_RS06775	COG0058	SHG alpha-glucan phosphorylase activity
W7S_RS06785	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
W7S_RS06810	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
W7S_RS06815	COG1234	tRNA 3'-trailer cleavage
W7S_RS06820	COG2123	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
W7S_RS06825	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
W7S_RS06850	COG3011	Protein conserved in bacteria
W7S_RS06875	COG1028	Short-chain dehydrogenase reductase Sdr
W7S_RS06880	COG1960	acyl-CoA dehydrogenase activity
W7S_RS06890	COG0183	Belongs to the thiolase family
W7S_RS06895	COG1804	L-carnitine dehydratase bile acid-inducible protein F
W7S_RS06905	COG1802	Transcriptional regulator
W7S_RS06925	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
W7S_RS06935	COG1024	Enoyl-CoA hydratase
W7S_RS06940	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
W7S_RS06960	COG1028	Short-chain dehydrogenase reductase Sdr
W7S_RS06965	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
W7S_RS06975	COG1024	Enoyl-CoA hydratase
W7S_RS07000	COG1960	acyl-CoA dehydrogenase activity
W7S_RS07010	COG0183	Belongs to the thiolase family
W7S_RS07060	COG4638	Rieske (2fe-2S)
W7S_RS07070	COG2072	flavoprotein involved in K transport
W7S_RS07090	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
W7S_RS07105	COG1309	transcriptional regulator
W7S_RS07125	COG2124	cytochrome p450
W7S_RS07130	COG0657	acetylesterase activity
W7S_RS07135	COG1960	acyl-CoA dehydrogenase activity
W7S_RS07140	COG1960	acyl-CoA dehydrogenase activity
W7S_RS07165	COG1960	acyl-CoA dehydrogenase activity
W7S_RS07170	COG1960	acyl-CoA dehydrogenase activity
W7S_RS07175	COG1960	acyl-CoA dehydrogenase activity
W7S_RS07180	COG1960	acyl-CoA dehydrogenase activity
W7S_RS07210	COG2124	cytochrome p450
W7S_RS07255	COG4638	Rieske (2fe-2S)
W7S_RS07270	COG3757	hydrolase, family 25
W7S_RS07275	COG3321	synthase
W7S_RS07275	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
W7S_RS07275	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
W7S_RS07280	COG0736	holo-[acyl-carrier-protein] synthase activity
W7S_RS07325	COG4552	Acetyltransferase involved in intracellular survival and related
W7S_RS07330	COG2409	Drug exporters of the RND superfamily
W7S_RS07335	COG0697	spore germination
W7S_RS07340	COG1376	ErfK ybiS ycfS ynhG family protein
W7S_RS07360	COG0433	COG0433 Predicted ATPase
W7S_RS07365	COG2826	transposase and inactivated derivatives, IS30 family
W7S_RS07370	COG0300	oxidoreductase activity
W7S_RS07390	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
W7S_RS07400	COG1960	acyl-CoA dehydrogenase activity
W7S_RS07405	COG2030	dehydratase
W7S_RS07425	COG0508	dehydrogenase complex catalyzes the overall conversion of
W7S_RS07445	COG0657	acetylesterase activity
W7S_RS07460	COG2937	Belongs to the GPAT DAPAT family
W7S_RS07470	COG4115	mRNA cleavage
W7S_RS07475	COG0629	single-stranded DNA binding
W7S_RS07485	COG2902	Dehydrogenase
W7S_RS07505	COG0366	Alpha amylase catalytic
W7S_RS07510	COG2346	COG2346, Truncated hemoglobins
W7S_RS07535	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
W7S_RS07540	COG0698	ribose 5-phosphate isomerase
W7S_RS07550	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
W7S_RS07570	COG0740	serine-type endopeptidase activity
W7S_RS07575	COG0740	serine-type endopeptidase activity
W7S_RS07580	COG2040	homocysteine
W7S_RS07595	COG0674	pyruvate-flavodoxin oxidoreductase activity
W7S_RS07595	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
W7S_RS07600	COG1013	pyruvate-flavodoxin oxidoreductase activity
W7S_RS07610	COG1388	LysM domain
W7S_RS07615	COG3268	Saccharopine dehydrogenase
W7S_RS07620	COG0525	valine-tRNA ligase activity
W7S_RS07625	COG0285	dihydrofolate synthase activity
W7S_RS07635	COG0105	UTP biosynthetic process
W7S_RS07640	COG1530	ribonuclease E activity
W7S_RS07655	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
W7S_RS07685	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
W7S_RS07685	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
W7S_RS07695	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
W7S_RS07700	COG5002	protein histidine kinase activity
W7S_RS07705	COG0668	transmembrane transport
W7S_RS07710	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
W7S_RS07715	COG0542	response to heat
W7S_RS07725	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
W7S_RS07730	COG0799	negative regulation of ribosome biogenesis
W7S_RS07740	COG2755	lipolytic protein G-D-S-L family
W7S_RS07765	COG0318	PFAM AMP-dependent synthetase and ligase
W7S_RS07770	COG5651	PPE family
W7S_RS07775	COG2409	Drug exporters of the RND superfamily
W7S_RS07795	COG1960	acyl-CoA dehydrogenase activity
W7S_RS07800	COG1960	acyl-CoA dehydrogenase activity
W7S_RS07805	COG1596	polysaccharide export
W7S_RS07805	COG1555	photosystem II stabilization
W7S_RS07835	COG1305	Transglutaminase-like
W7S_RS07840	COG1733	regulation of RNA biosynthetic process
W7S_RS07855	COG1234	tRNA 3'-trailer cleavage
W7S_RS07860	COG0517	IMP dehydrogenase activity
W7S_RS07870	COG0481	GTPase activity
W7S_RS07885	COG3387	PFAM Glycoside hydrolase 15-related
W7S_RS07895	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
W7S_RS07900	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
W7S_RS07905	COG4208	sulfate ABC transporter
W7S_RS07910	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
W7S_RS07920	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
W7S_RS07940	COG1169	isochorismate synthase
W7S_RS07950	COG2072	flavoprotein involved in K transport
W7S_RS07960	COG0300	oxidoreductase activity
W7S_RS08015	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
W7S_RS08020	COG3328	transposase activity
W7S_RS08040	COG1028	Short-chain dehydrogenase reductase Sdr
W7S_RS08065	COG1309	transcriptional regulator
W7S_RS08075	COG0494	nUDIX hydrolase
W7S_RS08090	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
W7S_RS08095	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
W7S_RS08100	COG1804	L-carnitine dehydratase bile acid-inducible protein F
W7S_RS08105	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
W7S_RS08180	COG1309	transcriptional regulator
W7S_RS08195	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
W7S_RS08200	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
W7S_RS08260	COG1024	Enoyl-CoA hydratase
W7S_RS08265	COG1024	Enoyl-CoA hydratase
W7S_RS08270	COG1024	Enoyl-CoA hydratase
W7S_RS08275	COG0318	PFAM AMP-dependent synthetase and ligase
W7S_RS08295	COG0183	Belongs to the thiolase family
W7S_RS08305	COG0183	Belongs to the thiolase family
W7S_RS08320	COG1233	COG1233 Phytoene dehydrogenase and related
W7S_RS08350	COG1028	Short-chain dehydrogenase reductase Sdr
W7S_RS08355	COG1012	belongs to the aldehyde dehydrogenase family
W7S_RS08370	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
W7S_RS08385	COG1804	L-carnitine dehydratase bile acid-inducible protein F
W7S_RS08390	COG1846	Transcriptional regulator
W7S_RS08415	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
W7S_RS08415	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
W7S_RS08420	COG1028	Short-chain dehydrogenase reductase Sdr
W7S_RS08445	COG4221	oxidoreductase activity
W7S_RS08475	COG2124	cytochrome p450
W7S_RS08480	COG0318	PFAM AMP-dependent synthetase and ligase
W7S_RS08485	COG1233	COG1233 Phytoene dehydrogenase and related
W7S_RS08490	COG1012	belongs to the aldehyde dehydrogenase family
W7S_RS08525	COG1902	pentaerythritol trinitrate reductase activity
W7S_RS08525	COG0446	pyridine nucleotide-disulphide oxidoreductase
W7S_RS08535	COG1028	Short-chain dehydrogenase reductase Sdr
W7S_RS08540	COG0318	PFAM AMP-dependent synthetase and ligase
W7S_RS08565	COG2124	cytochrome p450
W7S_RS08570	COG1960	acyl-CoA dehydrogenase activity
W7S_RS08600	COG2910	NAD(P)H-binding
W7S_RS08605	COG2124	cytochrome p450
W7S_RS08610	COG1902	pentaerythritol trinitrate reductase activity
W7S_RS08610	COG0446	pyridine nucleotide-disulphide oxidoreductase
W7S_RS08620	COG0574	Belongs to the PEP-utilizing enzyme family
W7S_RS08620	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
W7S_RS08690	COG3848	Pyruvate phosphate dikinase
W7S_RS08690	COG0574	Belongs to the PEP-utilizing enzyme family
W7S_RS08695	COG0183	Belongs to the thiolase family
W7S_RS08700	COG1960	acyl-CoA dehydrogenase activity
W7S_RS08710	COG1484	DNA-dependent DNA replication
W7S_RS08715	COG4584	PFAM Integrase catalytic
W7S_RS08735	COG4974	Belongs to the 'phage' integrase family
W7S_RS08740	COG4584	PFAM Integrase catalytic
W7S_RS08745	COG1484	DNA-dependent DNA replication
W7S_RS08815	COG2124	cytochrome p450
W7S_RS08835	COG1028	Short-chain dehydrogenase reductase Sdr
W7S_RS08855	COG0318	PFAM AMP-dependent synthetase and ligase
W7S_RS08865	COG1804	L-carnitine dehydratase bile acid-inducible protein F
W7S_RS08875	COG1063	alcohol dehydrogenase
W7S_RS08900	COG1028	Short-chain dehydrogenase reductase Sdr
W7S_RS08915	COG1309	transcriptional regulator
W7S_RS08930	COG1960	acyl-CoA dehydrogenase activity
W7S_RS08945	COG1960	acyl-CoA dehydrogenase activity
W7S_RS08960	COG1804	L-carnitine dehydratase bile acid-inducible protein F
W7S_RS08990	COG1960	acyl-CoA dehydrogenase activity
W7S_RS09000	COG1960	acyl-CoA dehydrogenase activity
W7S_RS09005	COG1960	acyl-CoA dehydrogenase activity
W7S_RS09010	COG1021	2,3-dihydroxybenzoate-AMP ligase
W7S_RS09020	COG1028	Short-chain dehydrogenase reductase Sdr
W7S_RS09050	COG1024	Enoyl-CoA hydratase
W7S_RS09060	COG1960	acyl-CoA dehydrogenase activity
W7S_RS09065	COG1024	Enoyl-CoA hydratase
W7S_RS09075	COG1024	Enoyl-CoA hydratase
W7S_RS09080	COG1028	Short-chain dehydrogenase reductase Sdr
W7S_RS09085	COG0318	PFAM AMP-dependent synthetase and ligase
W7S_RS09115	COG1024	Enoyl-CoA hydratase
W7S_RS09130	COG1960	acyl-CoA dehydrogenase activity
W7S_RS09145	COG1024	Enoyl-CoA hydratase
W7S_RS09200	COG4948	Mandelate Racemase Muconate Lactonizing
W7S_RS09205	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
W7S_RS09240	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
W7S_RS09315	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
W7S_RS09330	COG1309	transcriptional regulator
W7S_RS09335	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
W7S_RS09340	COG1021	2,3-dihydroxybenzoate-AMP ligase
W7S_RS09345	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
W7S_RS09360	COG3321	synthase
W7S_RS09360	COG0604	alcohol dehydrogenase
W7S_RS09365	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
W7S_RS09375	COG3486	L-lysine 6-monooxygenase (NADPH) activity
W7S_RS09395	COG1595	DNA-templated transcription, initiation
W7S_RS09410	COG1420	regulation of RNA biosynthetic process
W7S_RS09415	COG0484	heat shock protein binding
W7S_RS09450	COG1982	Orn Lys Arg decarboxylase major
W7S_RS09460	COG1381	Involved in DNA repair and RecF pathway recombination
W7S_RS09485	COG0423	glycine-tRNA ligase activity
W7S_RS09530	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
W7S_RS09535	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
W7S_RS09540	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
W7S_RS09545	COG1045	serine acetyltransferase
W7S_RS09555	COG2855	membrane
W7S_RS09560	COG4424	Sulfotransferase
W7S_RS09565	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
W7S_RS09570	COG0243	molybdopterin cofactor binding
W7S_RS09585	COG1131	(ABC) transporter
W7S_RS09585	COG0842	Transport permease protein
W7S_RS09585	COG1716	ATPase activity
W7S_RS09605	COG0531	amino acid
W7S_RS09620	COG1175	transmembrane transport
W7S_RS09655	COG3415	Transposase
W7S_RS09655	COG2801	Transposase and inactivated derivatives
W7S_RS09660	COG2267	carboxylic ester hydrolase activity
W7S_RS09690	COG1012	belongs to the aldehyde dehydrogenase family
W7S_RS09715	COG2208	phosphoserine phosphatase activity
W7S_RS09715	COG2172	sigma factor antagonist activity
W7S_RS09715	COG1366	Belongs to the anti-sigma-factor antagonist family
W7S_RS09730	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
W7S_RS09735	COG2226	methyltransferase
W7S_RS09815	COG2132	Multicopper oxidase
W7S_RS09835	COG0596	Alpha beta hydrolase
W7S_RS09850	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
W7S_RS09860	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
W7S_RS09865	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
W7S_RS09880	COG2124	cytochrome p450
W7S_RS09900	COG0798	PFAM Bile acid sodium symporter
W7S_RS09935	COG0438	transferase activity, transferring glycosyl groups
W7S_RS09950	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
W7S_RS09965	COG0657	acetylesterase activity
W7S_RS09970	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
W7S_RS09985	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
W7S_RS10005	COG1309	transcriptional regulator
W7S_RS10050	COG3328	transposase activity
W7S_RS10075	COG0210	DNA helicase
W7S_RS10085	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
W7S_RS10085	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
W7S_RS10090	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
W7S_RS10115	COG1960	acyl-CoA dehydrogenase activity
W7S_RS10120	COG0860	N-Acetylmuramoyl-L-alanine amidase
W7S_RS10130	COG2072	flavoprotein involved in K transport
W7S_RS10235	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
W7S_RS10260	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
W7S_RS10305	COG0596	Alpha beta hydrolase
W7S_RS10315	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
W7S_RS10530	COG4974	Belongs to the 'phage' integrase family
W7S_RS10555	COG0321	lipoyl(octanoyl) transferase activity
W7S_RS10590	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
W7S_RS10600	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
W7S_RS10605	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
W7S_RS10610	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
W7S_RS10640	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
W7S_RS10650	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
W7S_RS10685	COG1845	cytochrome c oxidase, subunit III
W7S_RS10710	COG1022	Amp-dependent synthetase and ligase
W7S_RS10725	COG0003	Pfam Anion-transporting ATPase
W7S_RS10755	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
W7S_RS10775	COG0142	geranyltranstransferase activity
W7S_RS10815	COG0768	penicillin binding
W7S_RS10855	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
W7S_RS10870	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
W7S_RS11010	COG3328	transposase activity
W7S_RS11040	COG3328	transposase activity
W7S_RS11095	COG2826	transposase and inactivated derivatives, IS30 family
W7S_RS11125	COG2072	flavoprotein involved in K transport
W7S_RS11170	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
W7S_RS11175	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
W7S_RS11200	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
W7S_RS11230	COG3328	transposase activity
W7S_RS11245	COG3328	transposase activity
W7S_RS11285	COG2072	flavoprotein involved in K transport
W7S_RS11300	COG2072	flavoprotein involved in K transport
W7S_RS11315	COG0318	PFAM AMP-dependent synthetase and ligase
W7S_RS11360	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
W7S_RS11370	COG0167	dihydroorotate dehydrogenase activity
W7S_RS11405	COG1218	3'(2'),5'-bisphosphate nucleotidase
W7S_RS11410	COG0215	cysteine-tRNA ligase activity
W7S_RS11440	COG3321	synthase
W7S_RS11440	COG0604	alcohol dehydrogenase
W7S_RS11440	COG1028	Short-chain dehydrogenase reductase Sdr
W7S_RS11445	COG2124	cytochrome p450
W7S_RS11460	COG0318	PFAM AMP-dependent synthetase and ligase
W7S_RS11465	COG1028	Short-chain dehydrogenase reductase Sdr
W7S_RS11480	COG0646	methionine synthase
W7S_RS11480	COG1410	methionine synthase
W7S_RS11525	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
W7S_RS11535	COG1309	transcriptional regulator
W7S_RS11605	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
W7S_RS11675	COG0300	oxidoreductase activity
W7S_RS11720	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
W7S_RS11750	COG1028	Short-chain dehydrogenase reductase Sdr
W7S_RS11765	COG0412	Dienelactone hydrolase
W7S_RS11800	COG3321	synthase
W7S_RS11800	COG0604	alcohol dehydrogenase
W7S_RS11815	COG1028	Short-chain dehydrogenase reductase Sdr
W7S_RS11845	COG0714	Associated with various cellular activities
W7S_RS11880	COG1028	Short-chain dehydrogenase reductase Sdr
W7S_RS11905	COG2272	Belongs to the type-B carboxylesterase lipase family
W7S_RS11915	COG3265	gluconokinase activity
W7S_RS11935	COG1335	isochorismatase
W7S_RS11950	COG1595	DNA-templated transcription, initiation
W7S_RS11960	COG1175	transmembrane transport
W7S_RS11965	COG0395	ABC-type sugar transport system, permease component
W7S_RS11970	COG3842	ATPase activity
W7S_RS11975	COG1752	Esterase of the alpha-beta hydrolase superfamily
W7S_RS12000	COG2837	iron assimilation
W7S_RS12010	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
W7S_RS12040	COG0667	Aldo Keto reductase
W7S_RS12050	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
W7S_RS12070	COG1960	acyl-CoA dehydrogenase activity
W7S_RS12120	COG0523	cobalamin synthesis protein
W7S_RS12125	COG1946	Acyl-CoA thioesterase
W7S_RS12150	COG1484	DNA-dependent DNA replication
W7S_RS12155	COG4584	PFAM Integrase catalytic
W7S_RS12175	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
W7S_RS12195	COG1595	DNA-templated transcription, initiation
W7S_RS12240	COG2204	response regulator
W7S_RS12270	COG1116	anion transmembrane transporter activity
W7S_RS12285	COG0583	DNA-binding transcription factor activity
W7S_RS12310	COG0545	Peptidyl-prolyl cis-trans isomerase
W7S_RS12320	COG1028	Short-chain dehydrogenase reductase Sdr
W7S_RS12340	COG2301	Belongs to the HpcH HpaI aldolase family
W7S_RS12350	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
W7S_RS12360	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
W7S_RS12365	COG1643	Atp-dependent helicase
W7S_RS12375	COG1024	Enoyl-CoA hydratase
W7S_RS12395	COG1063	alcohol dehydrogenase
W7S_RS12440	COG0723	plastoquinol--plastocyanin reductase activity
W7S_RS12440	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
W7S_RS12450	COG1376	ErfK ybiS ycfS ynhG family protein
W7S_RS12465	COG3757	hydrolase, family 25
W7S_RS12470	COG0438	transferase activity, transferring glycosyl groups
W7S_RS12475	COG2226	methyltransferase
W7S_RS12495	COG1309	transcriptional regulator
W7S_RS12505	COG3391	amine dehydrogenase activity
W7S_RS12515	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
W7S_RS12580	COG1012	belongs to the aldehyde dehydrogenase family
W7S_RS12635	COG4977	sequence-specific DNA binding
W7S_RS12650	COG1028	Short-chain dehydrogenase reductase Sdr
W7S_RS12660	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
W7S_RS12695	COG0640	Transcriptional regulator
W7S_RS12715	COG1233	COG1233 Phytoene dehydrogenase and related
W7S_RS12725	COG1942	4-Oxalocrotonate Tautomerase
W7S_RS12755	COG1950	PFAM Membrane protein of
W7S_RS12760	COG1403	HNH endonuclease
W7S_RS12770	COG2814	Major facilitator Superfamily
W7S_RS12775	COG1058	Belongs to the CinA family
W7S_RS12775	COG1546	Belongs to the CinA family
W7S_RS12800	COG1063	alcohol dehydrogenase
W7S_RS12810	COG2070	2-Nitropropane dioxygenase
W7S_RS12850	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
W7S_RS12860	COG1652	LysM domain
W7S_RS12895	COG0174	glutamine synthetase
W7S_RS12905	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
W7S_RS12915	COG2193	ferroxidase activity
W7S_RS12925	COG1024	Enoyl-CoA hydratase
W7S_RS12950	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
W7S_RS13010	COG1804	L-carnitine dehydratase bile acid-inducible protein F
W7S_RS13015	COG1968	undecaprenyl-diphosphatase activity
W7S_RS13020	COG4221	oxidoreductase activity
W7S_RS13075	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
W7S_RS13085	COG1252	NADH dehydrogenase
W7S_RS13105	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
W7S_RS13120	COG0318	PFAM AMP-dependent synthetase and ligase
W7S_RS13125	COG1960	acyl-CoA dehydrogenase activity
W7S_RS13130	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
W7S_RS13135	COG1253	flavin adenine dinucleotide binding
W7S_RS13140	COG1253	flavin adenine dinucleotide binding
W7S_RS13235	COG3976	FMN-binding domain protein
W7S_RS13235	COG1053	succinate dehydrogenase
W7S_RS13265	COG1285	pathogenesis
W7S_RS13275	COG5651	PPE family
W7S_RS13295	COG5651	PPE family
W7S_RS13320	COG1404	Belongs to the peptidase S8 family
W7S_RS13350	COG5651	PPE family
W7S_RS13355	COG5651	PPE family
W7S_RS13395	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
W7S_RS13420	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
W7S_RS13440	COG1028	Short-chain dehydrogenase reductase Sdr
W7S_RS13445	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
W7S_RS13450	COG0022	dehydrogenase e1 component
W7S_RS13460	COG1024	Enoyl-CoA hydratase
W7S_RS13465	COG0318	PFAM AMP-dependent synthetase and ligase
W7S_RS13470	COG4638	Rieske (2fe-2S)
W7S_RS13475	COG1053	succinate dehydrogenase
W7S_RS13505	COG0513	Belongs to the DEAD box helicase family
W7S_RS13510	COG2813	Specifically methylates the guanine in position
W7S_RS13570	COG4221	oxidoreductase activity
W7S_RS13600	COG4221	oxidoreductase activity
W7S_RS13605	COG1804	L-carnitine dehydratase bile acid-inducible protein F
W7S_RS13610	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
W7S_RS13615	COG1028	Short-chain dehydrogenase reductase Sdr
W7S_RS13660	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
W7S_RS13680	COG0318	PFAM AMP-dependent synthetase and ligase
W7S_RS13710	COG0318	PFAM AMP-dependent synthetase and ligase
W7S_RS13715	COG2072	flavoprotein involved in K transport
W7S_RS13735	COG2030	dehydratase
W7S_RS13740	COG1960	acyl-CoA dehydrogenase activity
W7S_RS13745	COG1960	acyl-CoA dehydrogenase activity
W7S_RS13750	COG0842	Transport permease protein
W7S_RS13750	COG1131	(ABC) transporter
W7S_RS13750	COG1716	ATPase activity
W7S_RS13755	COG0657	acetylesterase activity
W7S_RS13760	COG1028	Short-chain dehydrogenase reductase Sdr
W7S_RS13765	COG0243	molybdopterin cofactor binding
W7S_RS13785	COG2267	carboxylic ester hydrolase activity
W7S_RS13810	COG2072	flavoprotein involved in K transport
W7S_RS13825	COG0346	lactoylglutathione lyase activity
W7S_RS13860	COG1028	Short-chain dehydrogenase reductase Sdr
W7S_RS13865	COG2072	flavoprotein involved in K transport
W7S_RS13870	COG0318	PFAM AMP-dependent synthetase and ligase
W7S_RS13875	COG1960	acyl-CoA dehydrogenase activity
W7S_RS13895	COG0657	acetylesterase activity
W7S_RS13905	COG1028	Short-chain dehydrogenase reductase Sdr
W7S_RS13915	COG1028	Short-chain dehydrogenase reductase Sdr
W7S_RS13930	COG1053	succinate dehydrogenase
W7S_RS13990	COG2271	Major facilitator Superfamily
W7S_RS13995	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
W7S_RS13995	COG0189	ligase activity
W7S_RS14020	COG1305	Transglutaminase-like
W7S_RS14030	COG1278	Cold shock
W7S_RS14095	COG0789	Transcriptional regulator
W7S_RS14110	COG4584	PFAM Integrase catalytic
W7S_RS14115	COG1484	DNA-dependent DNA replication
W7S_RS14165	COG2239	Acts as a magnesium transporter
W7S_RS14175	COG2132	Multicopper oxidase
W7S_RS14180	COG2226	methyltransferase
W7S_RS14190	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
W7S_RS14235	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
W7S_RS14250	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
W7S_RS14275	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
W7S_RS14290	COG3321	synthase
W7S_RS14290	COG0604	alcohol dehydrogenase
W7S_RS14320	COG1937	Protein conserved in bacteria
W7S_RS14330	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
W7S_RS14340	COG0019	diaminopimelate decarboxylase activity
W7S_RS14355	COG4584	PFAM Integrase catalytic
W7S_RS14385	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
W7S_RS14395	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
W7S_RS14420	COG0494	nUDIX hydrolase
W7S_RS14445	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
W7S_RS14460	COG0647	UMP catabolic process
W7S_RS14475	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
W7S_RS14480	COG2094	Belongs to the DNA glycosylase MPG family
W7S_RS14490	COG1131	(ABC) transporter
W7S_RS14500	COG1309	transcriptional regulator
W7S_RS14505	COG2835	tetraacyldisaccharide 4'-kinase activity
W7S_RS14535	COG0300	oxidoreductase activity
W7S_RS14540	COG4948	Mandelate Racemase Muconate Lactonizing
W7S_RS14545	COG3707	response regulator
W7S_RS14550	COG0488	(ABC) transporter
W7S_RS14565	COG3321	synthase
W7S_RS14565	COG0604	alcohol dehydrogenase
W7S_RS14565	COG0604	alcohol dehydrogenase
W7S_RS14565	COG3321	synthase
W7S_RS14570	COG3321	synthase
W7S_RS14570	COG0604	alcohol dehydrogenase
W7S_RS14575	COG3321	synthase
W7S_RS14575	COG0604	alcohol dehydrogenase
W7S_RS14585	COG0165	Argininosuccinate lyase
W7S_RS14600	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
W7S_RS14615	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
W7S_RS14620	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
W7S_RS14625	COG0072	phenylalanine-tRNA ligase activity
W7S_RS14625	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
W7S_RS14630	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
W7S_RS14660	COG0291	Belongs to the bacterial ribosomal protein bL35 family
W7S_RS14685	COG1309	transcriptional regulator
W7S_RS14745	COG1716	ATPase activity
W7S_RS14745	COG1131	(ABC) transporter
W7S_RS14745	COG0842	Transport permease protein
W7S_RS14755	COG2201	protein-glutamate methylesterase activity
W7S_RS14770	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
W7S_RS14780	COG0237	dephospho-CoA kinase activity
W7S_RS14780	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
W7S_RS14835	COG1271	oxidase subunit
W7S_RS14840	COG1294	oxidase, subunit
W7S_RS14845	COG4988	ABC transporter
W7S_RS14850	COG1132	(ABC) transporter
W7S_RS14865	COG1946	Acyl-CoA thioesterase
W7S_RS14905	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
W7S_RS14915	COG0387	Pfam Sodium calcium exchanger
W7S_RS14920	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
W7S_RS14930	COG0483	inositol monophosphate 1-phosphatase activity
W7S_RS14940	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
W7S_RS14945	COG0131	Imidazoleglycerol-phosphate dehydratase
W7S_RS14955	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
W7S_RS14965	COG0157	Belongs to the NadC ModD family
W7S_RS15025	COG5002	protein histidine kinase activity
W7S_RS15030	COG0668	transmembrane transport
W7S_RS15045	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
W7S_RS15055	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
W7S_RS15065	COG0791	NLP P60 protein
W7S_RS15065	COG3883	PFAM NLP P60 protein
W7S_RS15100	COG0671	phosphoesterase, PA-phosphatase related
W7S_RS15130	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
W7S_RS15155	COG0300	oxidoreductase activity
W7S_RS15165	COG2346	COG2346, Truncated hemoglobins
W7S_RS15185	COG0252	asparaginase activity
W7S_RS15195	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
W7S_RS15205	COG2070	2-Nitropropane dioxygenase
W7S_RS15270	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
W7S_RS15275	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
W7S_RS15300	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
W7S_RS15315	COG3386	PFAM SMP-30 Gluconolaconase
W7S_RS15330	COG4221	oxidoreductase activity
W7S_RS15385	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
W7S_RS15430	COG2205	protein histidine kinase activity
W7S_RS15435	COG0745	RESPONSE REGULATOR receiver
W7S_RS15470	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
W7S_RS15475	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
W7S_RS15485	COG2826	transposase and inactivated derivatives, IS30 family
W7S_RS15495	COG2826	transposase and inactivated derivatives, IS30 family
W7S_RS15500	COG2304	oxidoreductase activity
W7S_RS15510	COG0714	Associated with various cellular activities
W7S_RS15520	COG0791	NLP P60 protein
W7S_RS15520	COG3883	PFAM NLP P60 protein
W7S_RS15530	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
W7S_RS15535	COG1309	transcriptional regulator
W7S_RS15545	COG0488	(ABC) transporter
W7S_RS15555	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
W7S_RS15560	COG1960	acyl-CoA dehydrogenase activity
W7S_RS15590	COG0251	oxidation-reduction process
W7S_RS15605	COG0183	Belongs to the thiolase family
W7S_RS15610	COG1028	Short-chain dehydrogenase reductase Sdr
W7S_RS15685	COG0657	acetylesterase activity
W7S_RS15735	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
W7S_RS15765	COG1028	Short-chain dehydrogenase reductase Sdr
W7S_RS15775	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
W7S_RS15800	COG2151	metal-sulfur cluster biosynthetic enzyme
W7S_RS15805	COG0822	iron-sulfur transferase activity
W7S_RS15815	COG0396	ATPase activity
W7S_RS15840	COG1131	(ABC) transporter
W7S_RS15875	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
W7S_RS15900	COG0123	including yeast histone deacetylase and acetoin utilization protein
W7S_RS15905	COG0667	Aldo Keto reductase
W7S_RS15910	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
W7S_RS15950	COG0318	PFAM AMP-dependent synthetase and ligase
W7S_RS15955	COG0657	acetylesterase activity
W7S_RS15960	COG1403	HNH endonuclease
W7S_RS15980	COG1660	Displays ATPase and GTPase activities
W7S_RS15985	COG0322	excinuclease ABC activity
W7S_RS16010	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
W7S_RS16075	COG0657	acetylesterase activity
W7S_RS16105	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
W7S_RS16130	COG0505	Belongs to the CarA family
W7S_RS16150	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
W7S_RS16160	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
W7S_RS16235	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
W7S_RS16260	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
W7S_RS16265	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
W7S_RS16270	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
W7S_RS16280	COG0432	Pfam Uncharacterised protein family UPF0047
W7S_RS16345	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
W7S_RS16365	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
W7S_RS16370	COG0235	Class ii aldolase
W7S_RS16375	COG1396	sequence-specific DNA binding
W7S_RS16410	COG1403	HNH endonuclease
W7S_RS16415	COG3328	transposase activity
W7S_RS16430	COG0124	histidyl-tRNA synthetase
W7S_RS16435	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
W7S_RS16450	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
W7S_RS16455	COG0747	negative chemotaxis
W7S_RS16460	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
W7S_RS16465	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
W7S_RS16480	COG1022	Amp-dependent synthetase and ligase
W7S_RS16480	COG3320	Male sterility
W7S_RS16530	COG3766	membrane
W7S_RS16550	COG1946	Acyl-CoA thioesterase
W7S_RS16575	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
W7S_RS16605	COG0667	Aldo Keto reductase
W7S_RS16610	COG4762	Protein conserved in bacteria
W7S_RS16625	COG2070	2-Nitropropane dioxygenase
W7S_RS16665	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
W7S_RS16675	COG3485	protocatechuate 3,4-dioxygenase
W7S_RS16715	COG1414	Transcriptional regulator
W7S_RS16725	COG1309	transcriptional regulator
W7S_RS16730	COG1366	Belongs to the anti-sigma-factor antagonist family
W7S_RS16735	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
W7S_RS16745	COG0753	catalase activity
W7S_RS16750	COG1028	Short-chain dehydrogenase reductase Sdr
W7S_RS16770	COG1024	Enoyl-CoA hydratase
W7S_RS16810	COG1511	domain protein
W7S_RS16830	COG4689	acetoacetate decarboxylase
W7S_RS16865	COG1309	transcriptional regulator
W7S_RS16885	COG1012	belongs to the aldehyde dehydrogenase family
W7S_RS16945	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
W7S_RS16950	COG2264	protein methyltransferase activity
W7S_RS16955	COG3253	May function as heme-dependent peroxidase
W7S_RS16995	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
W7S_RS17000	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
W7S_RS17005	COG0531	amino acid
W7S_RS17010	COG0569	domain protein
W7S_RS17060	COG0483	inositol monophosphate 1-phosphatase activity
W7S_RS17150	COG1388	LysM domain
W7S_RS17165	COG1960	acyl-CoA dehydrogenase activity
W7S_RS17170	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
W7S_RS17180	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
W7S_RS17195	COG1196	nuclear chromosome segregation
W7S_RS17205	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
W7S_RS17245	COG4308	Limonene-1,2-epoxide hydrolase catalytic domain
W7S_RS17260	COG1842	Phage shock protein A
W7S_RS17275	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
W7S_RS17305	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
W7S_RS17315	COG3214	Protein conserved in bacteria
W7S_RS17340	COG1960	acyl-CoA dehydrogenase activity
W7S_RS17345	COG1960	acyl-CoA dehydrogenase activity
W7S_RS17350	COG1028	Short-chain dehydrogenase reductase Sdr
W7S_RS17360	COG4770	biotin carboxylase activity
W7S_RS17365	COG0318	PFAM AMP-dependent synthetase and ligase
W7S_RS17385	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
W7S_RS17390	COG1403	HNH endonuclease
W7S_RS17435	COG0686	Belongs to the AlaDH PNT family
W7S_RS17480	COG1960	acyl-CoA dehydrogenase activity
W7S_RS17485	COG0183	Belongs to the thiolase family
W7S_RS17490	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
W7S_RS17495	COG2977	Belongs to the P-Pant transferase superfamily
W7S_RS17500	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
W7S_RS17535	COG0534	Mate efflux family protein
W7S_RS17540	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
W7S_RS17550	COG0481	GTPase activity
W7S_RS17590	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
W7S_RS17590	COG1648	precorrin-2 dehydrogenase activity
W7S_RS17615	COG0579	oxidoreductase
W7S_RS17630	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
W7S_RS17645	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
W7S_RS17660	COG1028	Short-chain dehydrogenase reductase Sdr
W7S_RS17670	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
W7S_RS17685	COG1492	cobalamin metabolic process
W7S_RS17710	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
W7S_RS17715	COG0750	zinc metalloprotease
W7S_RS17720	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
W7S_RS17730	COG0820	rRNA (adenine-C2-)-methyltransferase activity
W7S_RS17735	COG0575	Belongs to the CDS family
W7S_RS17755	COG0745	RESPONSE REGULATOR receiver
W7S_RS17770	COG1028	Short-chain dehydrogenase reductase Sdr
W7S_RS17790	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
W7S_RS17815	COG0154	amidase activity
W7S_RS17825	COG0052	Belongs to the universal ribosomal protein uS2 family
W7S_RS17885	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
W7S_RS17895	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
W7S_RS17910	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
W7S_RS17930	COG0336	Belongs to the RNA methyltransferase TrmD family
W7S_RS17945	COG0228	four-way junction DNA binding
W7S_RS17955	COG1686	Belongs to the peptidase S11 family
W7S_RS18000	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
W7S_RS18020	COG1196	nuclear chromosome segregation
W7S_RS18045	COG0571	ribonuclease III activity
W7S_RS18060	COG0701	Predicted permease
W7S_RS18065	COG0028	Belongs to the TPP enzyme family
W7S_RS18075	COG3328	transposase activity
W7S_RS18090	COG0742	ribosomal rna small subunit methyltransferase
W7S_RS18105	COG0657	acetylesterase activity
W7S_RS18125	COG1461	Dihydroxyacetone kinase
W7S_RS18195	COG1181	Belongs to the D-alanine--D-alanine ligase family
W7S_RS18200	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
W7S_RS18205	COG1920	GTP binding
W7S_RS18210	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
W7S_RS18255	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
W7S_RS18260	COG0179	Fumarylacetoacetate (FAA) hydrolase
W7S_RS18265	COG2271	Major facilitator Superfamily
W7S_RS18270	COG2271	Major facilitator Superfamily
W7S_RS18275	COG0473	3-isopropylmalate dehydrogenase activity
W7S_RS18290	COG0655	NAD(P)H dehydrogenase (quinone) activity
W7S_RS18305	COG0028	Belongs to the TPP enzyme family
W7S_RS18315	COG2259	Doxx family
W7S_RS18330	COG1192	Involved in chromosome partitioning
W7S_RS18335	COG0205	6-phosphofructokinase activity
W7S_RS18390	COG0626	cystathionine gamma-synthase activity
W7S_RS18440	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
W7S_RS18490	COG0142	geranyltranstransferase activity
W7S_RS18520	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
W7S_RS18560	COG1819	glycosyl
W7S_RS18565	COG1304	FMN binding
W7S_RS18570	COG2409	Drug exporters of the RND superfamily
W7S_RS18580	COG0415	Belongs to the DNA photolyase family
W7S_RS18590	COG0110	maltose O-acetyltransferase activity
W7S_RS18595	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
W7S_RS18620	COG1024	Enoyl-CoA hydratase
W7S_RS18630	COG1119	ATPase activity
W7S_RS18640	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
W7S_RS18670	COG1309	transcriptional regulator
W7S_RS18680	COG2072	flavoprotein involved in K transport
W7S_RS18685	COG1309	transcriptional regulator
W7S_RS18755	COG2186	Transcriptional regulator
W7S_RS18770	COG1960	acyl-CoA dehydrogenase activity
W7S_RS18780	COG1793	dna ligase
W7S_RS18785	COG0443	Heat shock 70 kDa protein
W7S_RS18795	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
W7S_RS18800	COG0183	Belongs to the thiolase family
W7S_RS18805	COG1024	Enoyl-CoA hydratase
W7S_RS18810	COG1804	L-carnitine dehydratase bile acid-inducible protein F
W7S_RS18835	COG1028	Short-chain dehydrogenase reductase Sdr
W7S_RS18850	COG2076	Multidrug Resistance protein
W7S_RS18900	COG4638	Rieske (2fe-2S)
W7S_RS18905	COG1028	Short-chain dehydrogenase reductase Sdr
W7S_RS18930	COG4638	Rieske (2fe-2S)
W7S_RS18945	COG0318	PFAM AMP-dependent synthetase and ligase
W7S_RS18960	COG3654	unkown
W7S_RS18980	COG0477	Major facilitator Superfamily
W7S_RS18990	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
W7S_RS18995	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
W7S_RS19020	COG2301	Belongs to the HpcH HpaI aldolase family
W7S_RS19035	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
W7S_RS19130	COG4638	Rieske (2fe-2S)
W7S_RS19140	COG1131	(ABC) transporter
W7S_RS19140	COG0842	Transport permease protein
W7S_RS19140	COG1716	ATPase activity
W7S_RS19150	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
W7S_RS19150	COG2755	lipolytic protein G-D-S-L family
W7S_RS19180	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
W7S_RS19185	COG2177	Part of the ABC transporter FtsEX involved in
W7S_RS19190	COG2884	Cell division ATP-binding protein ftsE
W7S_RS19200	COG0668	transmembrane transport
W7S_RS19210	COG0493	'glutamate synthase
W7S_RS19275	COG0483	inositol monophosphate 1-phosphatase activity
W7S_RS19285	COG1960	acyl-CoA dehydrogenase activity
W7S_RS19290	COG0667	Aldo Keto reductase
W7S_RS19295	COG0604	alcohol dehydrogenase
W7S_RS19315	COG1804	L-carnitine dehydratase bile acid-inducible protein F
W7S_RS19320	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
W7S_RS19330	COG1960	acyl-CoA dehydrogenase activity
W7S_RS19345	COG2353	YceI-like domain
W7S_RS19365	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
W7S_RS19385	COG1034	ATP synthesis coupled electron transport
W7S_RS19390	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
W7S_RS19405	COG0713	ATP synthesis coupled electron transport
W7S_RS19435	COG0714	Associated with various cellular activities
W7S_RS19485	COG0297	glycogen (starch) synthase activity
W7S_RS19500	COG2201	protein-glutamate methylesterase activity
W7S_RS19540	COG3237	CsbD-like
W7S_RS19550	COG0651	ATP synthesis coupled electron transport
W7S_RS19555	COG1006	Multisubunit Na H antiporter MnhC subunit
W7S_RS19570	COG1320	monovalent cation:proton antiporter activity
W7S_RS19575	COG2212	antiporter activity
W7S_RS19595	COG0028	Belongs to the TPP enzyme family
W7S_RS19600	COG1573	uracil-dna glycosylase
W7S_RS19655	COG0789	Transcriptional regulator
W7S_RS19665	COG3707	response regulator
W7S_RS19675	COG2197	response regulator
W7S_RS19745	COG0386	Belongs to the glutathione peroxidase family
W7S_RS19770	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
W7S_RS19780	COG0783	Belongs to the Dps family
W7S_RS19795	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
W7S_RS19845	COG3480	Lon protease (S16) C-terminal proteolytic domain
W7S_RS19860	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
W7S_RS19895	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
W7S_RS19915	COG0596	Alpha beta hydrolase
W7S_RS19960	COG0513	Belongs to the DEAD box helicase family
W7S_RS19975	COG0406	alpha-ribazole phosphatase activity
W7S_RS20010	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
W7S_RS20030	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
W7S_RS20035	COG1063	alcohol dehydrogenase
W7S_RS20050	COG1028	Short-chain dehydrogenase reductase Sdr
W7S_RS20060	COG1028	Short-chain dehydrogenase reductase Sdr
W7S_RS20125	COG2135	peptidase activity
W7S_RS20130	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
W7S_RS20135	COG1162	GTPase activity
W7S_RS20140	COG1733	regulation of RNA biosynthetic process
W7S_RS20145	COG0183	Belongs to the thiolase family
W7S_RS20160	COG1309	transcriptional regulator
W7S_RS20195	COG2020	methyltransferase activity
W7S_RS20200	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
W7S_RS20210	COG0653	protein targeting
W7S_RS20215	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
W7S_RS20225	COG5401	PFAM Sporulation and spore germination
W7S_RS20245	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
W7S_RS20265	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
W7S_RS20270	COG0531	amino acid
W7S_RS20275	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
W7S_RS20280	COG1482	cell wall glycoprotein biosynthetic process
W7S_RS20290	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
W7S_RS20330	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
W7S_RS20345	COG1316	TRANSCRIPTIONal
W7S_RS20370	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
W7S_RS20375	COG1804	L-carnitine dehydratase bile acid-inducible protein F
W7S_RS20415	COG0784	Response regulator, receiver
W7S_RS20420	COG4251	negative regulation of phosphorylation
W7S_RS20435	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
W7S_RS20440	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
W7S_RS20460	COG1053	succinate dehydrogenase
W7S_RS20465	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
W7S_RS20475	COG0424	maF-like protein
W7S_RS20490	COG4770	biotin carboxylase activity
W7S_RS20495	COG1366	Belongs to the anti-sigma-factor antagonist family
W7S_RS20525	COG1522	sequence-specific DNA binding
W7S_RS20535	COG1012	belongs to the aldehyde dehydrogenase family
W7S_RS20540	COG1309	transcriptional regulator
W7S_RS20545	COG1201	RNA secondary structure unwinding
W7S_RS20580	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
W7S_RS20590	COG0564	pseudouridine synthase activity
W7S_RS20595	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
W7S_RS20610	COG0657	acetylesterase activity
W7S_RS20615	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
W7S_RS20615	COG1473	amidohydrolase
W7S_RS20620	COG1473	amidohydrolase
W7S_RS20635	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
W7S_RS20640	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
W7S_RS20645	COG3511	phospholipase C
W7S_RS20655	COG2304	oxidoreductase activity
W7S_RS20660	COG2304	oxidoreductase activity
W7S_RS20695	COG2009	succinate dehydrogenase
W7S_RS20705	COG1053	succinate dehydrogenase
W7S_RS20710	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
W7S_RS20725	COG1595	DNA-templated transcription, initiation
W7S_RS20730	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
W7S_RS20740	COG1686	Belongs to the peptidase S11 family
W7S_RS20745	COG2814	Major facilitator Superfamily
W7S_RS20760	COG1295	ribonuclease BN
W7S_RS20785	COG2873	o-acetylhomoserine
W7S_RS20880	COG1716	ATPase activity
W7S_RS20880	COG1131	(ABC) transporter
W7S_RS20880	COG0842	Transport permease protein
W7S_RS20885	COG1716	ATPase activity
W7S_RS20885	COG1131	(ABC) transporter
W7S_RS20885	COG0842	Transport permease protein
W7S_RS20890	COG1357	PFAM Pentapeptide repeats (8 copies)
W7S_RS20905	COG2018	Roadblock/LC7 domain
W7S_RS20910	COG5002	protein histidine kinase activity
W7S_RS20920	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
W7S_RS20935	COG0587	DNA-directed DNA polymerase activity
W7S_RS20940	COG1877	trehalose-phosphatase activity
W7S_RS20940	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
W7S_RS20945	COG2030	dehydratase
W7S_RS20950	COG0406	alpha-ribazole phosphatase activity
W7S_RS20955	COG4221	oxidoreductase activity
W7S_RS20960	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
W7S_RS20980	COG0028	Belongs to the TPP enzyme family
W7S_RS20985	COG0247	lactate metabolic process
W7S_RS20985	COG0277	FAD linked oxidase domain protein
W7S_RS21005	COG2124	cytochrome p450
W7S_RS21020	COG1028	Short-chain dehydrogenase reductase Sdr
W7S_RS21045	COG0519	Catalyzes the synthesis of GMP from XMP
W7S_RS21045	COG0518	GMP synthase (glutamine-hydrolyzing) activity
W7S_RS21130	COG2032	superoxide dismutase activity
W7S_RS21150	COG1309	transcriptional regulator
W7S_RS21160	COG0459	protein refolding
W7S_RS21175	COG0456	acetyltransferase
W7S_RS21185	COG0802	atpase or kinase
W7S_RS21200	COG0076	glutamate decarboxylase activity
W7S_RS21220	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
W7S_RS21240	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
W7S_RS21270	COG4842	Belongs to the WXG100 family
W7S_RS21275	COG4842	Belongs to the WXG100 family
W7S_RS21285	COG1674	ftsk spoiiie
W7S_RS21295	COG1404	Belongs to the peptidase S8 family
W7S_RS21315	COG0101	tRNA pseudouridine synthase activity
W7S_RS21335	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
W7S_RS21340	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
W7S_RS21345	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
W7S_RS21355	COG2205	protein histidine kinase activity
W7S_RS21410	COG3794	PFAM blue (type 1) copper domain protein
W7S_RS21435	COG1960	acyl-CoA dehydrogenase activity
W7S_RS21450	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
W7S_RS21465	COG0028	Belongs to the TPP enzyme family
W7S_RS21470	COG0577	efflux transmembrane transporter activity
W7S_RS21470	COG1136	(ABC) transporter
W7S_RS21475	COG0577	efflux transmembrane transporter activity
W7S_RS21480	COG2226	methyltransferase
W7S_RS21490	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
W7S_RS21510	COG0563	adenylate kinase activity
W7S_RS21520	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
W7S_RS21530	COG1070	Carbohydrate kinase
W7S_RS21550	COG1063	alcohol dehydrogenase
W7S_RS21555	COG4221	oxidoreductase activity
W7S_RS21575	COG0616	signal peptide processing
W7S_RS21580	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
W7S_RS21595	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
W7S_RS21600	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
W7S_RS21625	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
W7S_RS21670	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
W7S_RS21715	COG1914	H( )-stimulated, divalent metal cation uptake system
W7S_RS21720	COG5651	PPE family
W7S_RS21770	COG2239	Acts as a magnesium transporter
W7S_RS21825	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
W7S_RS21830	COG1403	HNH endonuclease
W7S_RS21835	COG1262	PFAM Formylglycine-generating sulfatase enzyme
W7S_RS21845	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
W7S_RS21885	COG0088	Forms part of the polypeptide exit tunnel
W7S_RS21910	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
W7S_RS21935	COG0535	radical SAM domain protein
W7S_RS21960	COG0483	inositol monophosphate 1-phosphatase activity
W7S_RS21970	COG1028	Short-chain dehydrogenase reductase Sdr
W7S_RS21995	COG0049	tRNA binding
W7S_RS22005	COG1309	transcriptional regulator
W7S_RS22020	COG1024	Enoyl-CoA hydratase
W7S_RS22035	COG1960	acyl-CoA dehydrogenase activity
W7S_RS22075	COG0222	ribosome binding
W7S_RS22110	COG2318	DinB family
W7S_RS22125	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
W7S_RS22130	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
W7S_RS22140	COG4941	Belongs to the sigma-70 factor family
W7S_RS22160	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
W7S_RS22170	COG2030	dehydratase
W7S_RS22175	COG2030	dehydratase
W7S_RS22180	COG2030	dehydratase
W7S_RS22205	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
W7S_RS22220	COG0243	molybdopterin cofactor binding
W7S_RS22230	COG1752	Esterase of the alpha-beta hydrolase superfamily
W7S_RS22245	COG0778	Nitroreductase
W7S_RS22250	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
W7S_RS22255	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
W7S_RS22260	COG1074	ATP-dependent DNA helicase activity
W7S_RS22290	COG3537	Alpha-1,2-mannosidase
W7S_RS22310	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
W7S_RS22345	COG2124	cytochrome p450
W7S_RS22355	COG1914	H( )-stimulated, divalent metal cation uptake system
W7S_RS22360	COG0243	molybdopterin cofactor binding
W7S_RS22380	COG2072	flavoprotein involved in K transport
W7S_RS22390	COG0659	secondary active sulfate transmembrane transporter activity
W7S_RS22400	COG0501	Belongs to the peptidase M48B family
W7S_RS22405	COG0142	geranyltranstransferase activity
W7S_RS22420	COG2226	methyltransferase
W7S_RS22425	COG0300	oxidoreductase activity
W7S_RS22450	COG4948	Mandelate Racemase Muconate Lactonizing
W7S_RS22455	COG1228	amidohydrolase
W7S_RS22470	COG0318	PFAM AMP-dependent synthetase and ligase
W7S_RS22480	COG0667	Aldo Keto reductase
W7S_RS22495	COG4221	oxidoreductase activity
W7S_RS22550	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
W7S_RS22555	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
W7S_RS22575	COG2894	cell division
W7S_RS22580	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
W7S_RS22590	COG0785	Cytochrome C biogenesis protein
W7S_RS22600	COG0406	alpha-ribazole phosphatase activity
W7S_RS22620	COG4948	Mandelate Racemase Muconate Lactonizing
W7S_RS22625	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
W7S_RS22635	COG1113	amino acid transport
W7S_RS22645	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
W7S_RS22655	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
W7S_RS22655	COG2755	lipolytic protein G-D-S-L family
W7S_RS22665	COG2755	lipolytic protein G-D-S-L family
W7S_RS22675	COG1366	Belongs to the anti-sigma-factor antagonist family
W7S_RS22740	COG2030	dehydratase
W7S_RS22805	COG0588	phosphoglycerate mutase activity
W7S_RS22815	COG0438	transferase activity, transferring glycosyl groups
W7S_RS22855	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
W7S_RS22880	COG2733	membrane
W7S_RS22895	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
W7S_RS22955	COG1505	serine-type exopeptidase activity
W7S_RS22965	COG1024	Enoyl-CoA hydratase
W7S_RS22975	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
W7S_RS23020	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
W7S_RS23040	COG4221	oxidoreductase activity
W7S_RS23070	COG1028	Short-chain dehydrogenase reductase Sdr
W7S_RS23080	COG0738	Major facilitator superfamily
W7S_RS23095	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
W7S_RS23145	COG2032	superoxide dismutase activity
W7S_RS23160	COG0242	peptide deformylase activity
W7S_RS23190	COG3707	response regulator
W7S_RS23255	COG1088	dTDP-glucose 4,6-dehydratase activity
W7S_RS23260	COG2234	aminopeptidase activity
W7S_RS23265	COG2234	aminopeptidase activity
W7S_RS23305	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
W7S_RS23305	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
W7S_RS23325	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
W7S_RS23340	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
W7S_RS23355	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
W7S_RS23375	COG1028	Short-chain dehydrogenase reductase Sdr
W7S_RS23380	COG1960	acyl-CoA dehydrogenase activity
W7S_RS23400	COG1252	NADH dehydrogenase
W7S_RS23410	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
W7S_RS23430	COG0406	alpha-ribazole phosphatase activity
W7S_RS23440	COG1994	Peptidase M50
W7S_RS23510	COG0542	response to heat
W7S_RS23530	COG0789	Transcriptional regulator
W7S_RS23535	COG0484	heat shock protein binding
W7S_RS23540	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
W7S_RS23575	COG2814	Major facilitator Superfamily
W7S_RS23590	COG2181	nitrate reductase activity
W7S_RS23590	COG0247	lactate metabolic process
W7S_RS23620	COG2226	methyltransferase
W7S_RS23625	COG0477	Major facilitator Superfamily
W7S_RS23635	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
W7S_RS23675	COG1376	ErfK ybiS ycfS ynhG family protein
W7S_RS23695	COG0246	Mannitol dehydrogenase
W7S_RS23700	COG1070	Carbohydrate kinase
W7S_RS23740	COG2130	NADP-dependent
W7S_RS23800	COG0778	Nitroreductase
W7S_RS23805	COG1368	sulfuric ester hydrolase activity
W7S_RS23825	COG1404	Belongs to the peptidase S8 family
W7S_RS23875	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
W7S_RS23880	COG0254	rRNA binding
W7S_RS23895	COG0267	Belongs to the bacterial ribosomal protein bL33 family
W7S_RS23900	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
W7S_RS23905	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
W7S_RS23945	COG0346	lactoylglutathione lyase activity
W7S_RS23960	COG1960	acyl-CoA dehydrogenase activity
W7S_RS23970	COG0318	PFAM AMP-dependent synthetase and ligase
W7S_RS23980	COG2223	nitrite transmembrane transporter activity
W7S_RS23985	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
W7S_RS23995	COG1984	allophanate hydrolase subunit 2
W7S_RS24025	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
W7S_RS24025	COG2146	nitrite reductase [NAD(P)H] activity
W7S_RS24050	COG1053	succinate dehydrogenase
W7S_RS24070	COG1960	acyl-CoA dehydrogenase activity
W7S_RS24075	COG0183	Belongs to the thiolase family
W7S_RS24080	COG1028	Short-chain dehydrogenase reductase Sdr
W7S_RS24085	COG2030	dehydratase
W7S_RS24100	COG1472	Belongs to the glycosyl hydrolase 3 family
W7S_RS24110	COG4981	capsule polysaccharide biosynthetic process
W7S_RS24120	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
W7S_RS24180	COG0028	Belongs to the TPP enzyme family
W7S_RS24185	COG1012	belongs to the aldehyde dehydrogenase family
W7S_RS24190	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
W7S_RS24250	COG0586	Pfam SNARE associated Golgi protein
W7S_RS24270	COG1309	transcriptional regulator
W7S_RS24280	COG0318	PFAM AMP-dependent synthetase and ligase
W7S_RS24295	COG1024	Enoyl-CoA hydratase
W7S_RS24305	COG0657	acetylesterase activity
W7S_RS24315	COG2267	carboxylic ester hydrolase activity
W7S_RS24325	COG1228	amidohydrolase
W7S_RS24350	COG1024	Enoyl-CoA hydratase
W7S_RS24360	COG2203	Gaf domain
W7S_RS24360	COG2199	diguanylate cyclase activity
W7S_RS24365	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
W7S_RS24380	COG0220	tRNA (guanine-N7-)-methyltransferase activity
W7S_RS24390	COG2409	Drug exporters of the RND superfamily
W7S_RS24430	COG3590	peptidase
W7S_RS24435	COG0243	molybdopterin cofactor binding
W7S_RS24445	COG1376	ErfK ybiS ycfS ynhG family protein
W7S_RS24450	COG2814	Major facilitator Superfamily
W7S_RS24455	COG1937	Protein conserved in bacteria
W7S_RS24460	COG0129	dihydroxy-acid dehydratase activity
W7S_RS24475	COG4122	O-methyltransferase activity
W7S_RS24480	COG1472	Belongs to the glycosyl hydrolase 3 family
W7S_RS24495	COG2267	carboxylic ester hydrolase activity
W7S_RS24535	COG3619	membrane
W7S_RS24550	COG1714	RDD family
W7S_RS24565	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
W7S_RS24590	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
W7S_RS24595	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
W7S_RS24605	COG1802	Transcriptional regulator
W7S_RS24625	COG0657	acetylesterase activity
W7S_RS24650	COG1063	alcohol dehydrogenase
W7S_RS24655	COG2124	cytochrome p450
W7S_RS24675	COG4221	oxidoreductase activity
W7S_RS24685	COG1960	acyl-CoA dehydrogenase activity
W7S_RS24690	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
W7S_RS24725	COG0277	FAD linked oxidase domain protein
W7S_RS24745	COG1309	transcriptional regulator
W7S_RS24770	COG1960	acyl-CoA dehydrogenase activity
W7S_RS24775	COG2365	Tyrosine phosphatase family
W7S_RS24780	COG1028	Short-chain dehydrogenase reductase Sdr
W7S_RS24785	COG1012	belongs to the aldehyde dehydrogenase family
W7S_RS24810	COG1741	Belongs to the pirin family
W7S_RS24815	COG0783	Belongs to the Dps family
W7S_RS24835	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
W7S_RS24850	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
W7S_RS24865	COG3585	molybdate ion transport
W7S_RS24870	COG0596	Alpha beta hydrolase
W7S_RS24890	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
W7S_RS24925	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
W7S_RS24935	COG3546	catalase activity
W7S_RS24965	COG0842	Transport permease protein
W7S_RS24965	COG1129	ABC transporter
W7S_RS24985	COG3281	Trehalose synthase
W7S_RS24995	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
W7S_RS25015	COG0028	Belongs to the TPP enzyme family
W7S_RS25020	COG0583	DNA-binding transcription factor activity
W7S_RS25025	COG1376	ErfK ybiS ycfS ynhG family protein
W7S_RS25055	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
W7S_RS25055	COG2755	lipolytic protein G-D-S-L family
W7S_RS25065	COG0028	Belongs to the TPP enzyme family
W7S_RS25075	COG1028	Short-chain dehydrogenase reductase Sdr
W7S_RS25080	COG2072	flavoprotein involved in K transport
W7S_RS25090	COG1028	Short-chain dehydrogenase reductase Sdr
W7S_RS25095	COG3386	PFAM SMP-30 Gluconolaconase
W7S_RS25105	COG0318	PFAM AMP-dependent synthetase and ligase
W7S_RS25115	COG0318	PFAM AMP-dependent synthetase and ligase
W7S_RS25130	COG2826	transposase and inactivated derivatives, IS30 family
W7S_RS25165	COG0318	PFAM AMP-dependent synthetase and ligase
W7S_RS25180	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
W7S_RS25200	COG2226	methyltransferase
W7S_RS25210	COG0300	oxidoreductase activity
W7S_RS25250	COG1063	alcohol dehydrogenase
W7S_RS25270	COG1028	Short-chain dehydrogenase reductase Sdr
W7S_RS25290	COG2072	flavoprotein involved in K transport
W7S_RS25315	COG0583	DNA-binding transcription factor activity
W7S_RS25335	COG1028	Short-chain dehydrogenase reductase Sdr
W7S_RS25340	COG1028	Short-chain dehydrogenase reductase Sdr
W7S_RS25355	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
W7S_RS25375	COG1309	transcriptional regulator
W7S_RS25385	COG2826	transposase and inactivated derivatives, IS30 family
W7S_RS25390	COG1028	Short-chain dehydrogenase reductase Sdr
W7S_RS25395	COG0318	PFAM AMP-dependent synthetase and ligase
W7S_RS25420	COG1804	L-carnitine dehydratase bile acid-inducible protein F
W7S_RS25435	COG0464	growth
W7S_RS25450	COG1960	acyl-CoA dehydrogenase activity
W7S_RS25455	COG1309	transcriptional regulator
W7S_RS25480	COG3588	fructose-bisphosphate aldolase
W7S_RS25515	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
W7S_RS25520	COG4638	Rieske (2fe-2S)
W7S_RS25530	COG2197	response regulator
W7S_RS25535	COG4585	Histidine kinase
W7S_RS25550	COG1674	ftsk spoiiie
W7S_RS25590	COG0617	tRNA 3'-terminal CCA addition
W7S_RS25620	COG1595	DNA-templated transcription, initiation
W7S_RS25640	COG0860	N-Acetylmuramoyl-L-alanine amidase
W7S_RS25640	COG3409	Peptidoglycan-binding domain 1 protein
W7S_RS25655	COG1192	Involved in chromosome partitioning
W7S_RS25660	COG0357	Ribosomal RNA small subunit methyltransferase G
W7S_RS25670	COG0706	membrane insertase activity