locus-tag	class	description
A7U43_RS00055	COG0717	Belongs to the dCTP deaminase family
A7U43_RS00100	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A7U43_RS00105	COG3550	peptidyl-serine autophosphorylation
A7U43_RS00115	COG4608	Belongs to the ABC transporter superfamily
A7U43_RS00120	COG0444	Belongs to the ABC transporter superfamily
A7U43_RS00125	COG0601	transmembrane transport
A7U43_RS00130	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A7U43_RS00135	COG0747	negative chemotaxis
A7U43_RS00145	COG3387	PFAM Glycoside hydrolase 15-related
A7U43_RS00150	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A7U43_RS00175	COG1216	Glycosyl transferase, family 2
A7U43_RS00225	COG1366	Belongs to the anti-sigma-factor antagonist family
A7U43_RS00240	COG2890	protein-(glutamine-N5) methyltransferase activity
A7U43_RS00320	COG4106	trans-aconitate 2-methyltransferase activity
A7U43_RS00340	COG1404	Belongs to the peptidase S8 family
A7U43_RS00355	COG4842	Belongs to the WXG100 family
A7U43_RS00375	COG1674	ftsk spoiiie
A7U43_RS00380	COG3266	domain, Protein
A7U43_RS00385	COG0464	growth
A7U43_RS00400	COG0346	lactoylglutathione lyase activity
A7U43_RS00415	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A7U43_RS00420	COG1960	acyl-CoA dehydrogenase activity
A7U43_RS00425	COG1028	Short-chain dehydrogenase reductase Sdr
A7U43_RS00430	COG0318	PFAM AMP-dependent synthetase and ligase
A7U43_RS00440	COG1366	Belongs to the anti-sigma-factor antagonist family
A7U43_RS00450	COG1028	Short-chain dehydrogenase reductase Sdr
A7U43_RS00455	COG1595	DNA-templated transcription, initiation
A7U43_RS00465	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
A7U43_RS00485	COG1309	transcriptional regulator
A7U43_RS00510	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A7U43_RS00520	COG2072	flavoprotein involved in K transport
A7U43_RS00530	COG2144	transferase activity, transferring acyl groups
A7U43_RS00540	COG0297	glycogen (starch) synthase activity
A7U43_RS00550	COG3467	pyridoxamine 5'-phosphate
A7U43_RS00595	COG4638	Rieske (2fe-2S)
A7U43_RS00605	COG1609	Transcriptional regulator
A7U43_RS00610	COG3254	rhamnose metabolic process
A7U43_RS00615	COG2814	Major facilitator Superfamily
A7U43_RS00625	COG1028	Short-chain dehydrogenase reductase Sdr
A7U43_RS00625	COG3347	Dehydrogenase
A7U43_RS00630	COG1070	Carbohydrate kinase
A7U43_RS00645	COG1028	Short-chain dehydrogenase reductase Sdr
A7U43_RS00670	COG0714	Associated with various cellular activities
A7U43_RS00690	COG0693	protein deglycase activity
A7U43_RS00715	COG1028	Short-chain dehydrogenase reductase Sdr
A7U43_RS00725	COG1012	belongs to the aldehyde dehydrogenase family
A7U43_RS00745	COG1028	Short-chain dehydrogenase reductase Sdr
A7U43_RS00765	COG0243	molybdopterin cofactor binding
A7U43_RS00775	COG0596	Alpha beta hydrolase
A7U43_RS00780	COG2208	phosphoserine phosphatase activity
A7U43_RS00780	COG2770	Histidine kinase
A7U43_RS00810	COG0477	Major facilitator Superfamily
A7U43_RS00825	COG1063	alcohol dehydrogenase
A7U43_RS00835	COG1846	Transcriptional regulator
A7U43_RS00840	COG1764	response to oxidative stress
A7U43_RS00845	COG0531	amino acid
A7U43_RS00855	COG2957	Belongs to the agmatine deiminase family
A7U43_RS00860	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A7U43_RS00885	COG1984	allophanate hydrolase subunit 2
A7U43_RS00915	COG2146	nitrite reductase [NAD(P)H] activity
A7U43_RS00915	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A7U43_RS00955	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A7U43_RS00960	COG0318	PFAM AMP-dependent synthetase and ligase
A7U43_RS00970	COG5651	PPE family
A7U43_RS00995	COG1960	acyl-CoA dehydrogenase activity
A7U43_RS01000	COG0740	serine-type endopeptidase activity
A7U43_RS01005	COG0740	serine-type endopeptidase activity
A7U43_RS01010	COG1396	sequence-specific DNA binding
A7U43_RS01025	COG0183	Belongs to the thiolase family
A7U43_RS01030	COG1028	Short-chain dehydrogenase reductase Sdr
A7U43_RS01035	COG2030	dehydratase
A7U43_RS01050	COG1472	Belongs to the glycosyl hydrolase 3 family
A7U43_RS01065	COG4981	capsule polysaccharide biosynthetic process
A7U43_RS01100	COG2826	transposase and inactivated derivatives, IS30 family
A7U43_RS01120	COG1305	Transglutaminase-like
A7U43_RS01125	COG1960	acyl-CoA dehydrogenase activity
A7U43_RS01140	COG1960	acyl-CoA dehydrogenase activity
A7U43_RS01160	COG0318	PFAM AMP-dependent synthetase and ligase
A7U43_RS01165	COG0657	acetylesterase activity
A7U43_RS01185	COG0657	acetylesterase activity
A7U43_RS01190	COG1960	acyl-CoA dehydrogenase activity
A7U43_RS01220	COG2030	dehydratase
A7U43_RS01225	COG0640	Transcriptional regulator
A7U43_RS01240	COG4221	oxidoreductase activity
A7U43_RS01245	COG1024	Enoyl-CoA hydratase
A7U43_RS01265	COG1028	Short-chain dehydrogenase reductase Sdr
A7U43_RS01270	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
A7U43_RS01285	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A7U43_RS01295	COG2409	Drug exporters of the RND superfamily
A7U43_RS01335	COG2409	Drug exporters of the RND superfamily
A7U43_RS01355	COG3590	peptidase
A7U43_RS01360	COG1376	ErfK ybiS ycfS ynhG family protein
A7U43_RS01365	COG1937	Protein conserved in bacteria
A7U43_RS01380	COG3706	GGDEF domain
A7U43_RS01410	COG4122	O-methyltransferase activity
A7U43_RS01430	COG2267	carboxylic ester hydrolase activity
A7U43_RS01485	COG1309	transcriptional regulator
A7U43_RS01490	COG1846	Transcriptional regulator
A7U43_RS01530	COG0300	oxidoreductase activity
A7U43_RS01535	COG3619	membrane
A7U43_RS01565	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
A7U43_RS01590	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A7U43_RS01595	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A7U43_RS01625	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A7U43_RS01635	COG2186	Transcriptional regulator
A7U43_RS01655	COG1960	acyl-CoA dehydrogenase activity
A7U43_RS01675	COG1309	transcriptional regulator
A7U43_RS01685	COG4521	taurine ABC transporter
A7U43_RS01700	COG0657	acetylesterase activity
A7U43_RS01715	COG0656	L-ascorbic acid biosynthetic process
A7U43_RS01795	COG2801	Transposase and inactivated derivatives
A7U43_RS01815	COG1073	alpha beta
A7U43_RS01820	COG0477	Major facilitator Superfamily
A7U43_RS01825	COG2963	transposase activity
A7U43_RS01850	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
A7U43_RS01860	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A7U43_RS01870	COG3485	protocatechuate 3,4-dioxygenase
A7U43_RS01875	COG3485	protocatechuate 3,4-dioxygenase
A7U43_RS01880	COG1414	Transcriptional regulator
A7U43_RS01900	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A7U43_RS01930	COG0789	Transcriptional regulator
A7U43_RS01940	COG4644	lycopene metabolic process
A7U43_RS01995	COG4974	Belongs to the 'phage' integrase family
A7U43_RS02000	COG2801	Transposase and inactivated derivatives
A7U43_RS02030	COG2963	transposase activity
A7U43_RS02045	COG2963	transposase activity
A7U43_RS02065	COG1012	belongs to the aldehyde dehydrogenase family
A7U43_RS02115	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A7U43_RS02120	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A7U43_RS02125	COG1012	belongs to the aldehyde dehydrogenase family
A7U43_RS02150	COG0318	PFAM AMP-dependent synthetase and ligase
A7U43_RS02155	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A7U43_RS02175	COG1960	acyl-CoA dehydrogenase activity
A7U43_RS02180	COG1024	Enoyl-CoA hydratase
A7U43_RS02185	COG0318	PFAM AMP-dependent synthetase and ligase
A7U43_RS02190	COG0183	Belongs to the thiolase family
A7U43_RS02200	COG1309	transcriptional regulator
A7U43_RS02215	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A7U43_RS02235	COG0598	Magnesium transport protein CorA
A7U43_RS02240	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
A7U43_RS02245	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
A7U43_RS02260	COG1960	acyl-CoA dehydrogenase activity
A7U43_RS02265	COG2267	carboxylic ester hydrolase activity
A7U43_RS02270	COG4585	Histidine kinase
A7U43_RS02280	COG0583	DNA-binding transcription factor activity
A7U43_RS02285	COG2814	Major facilitator Superfamily
A7U43_RS02295	COG2365	Tyrosine phosphatase family
A7U43_RS02320	COG1028	Short-chain dehydrogenase reductase Sdr
A7U43_RS02325	COG1012	belongs to the aldehyde dehydrogenase family
A7U43_RS02330	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
A7U43_RS02335	COG1309	transcriptional regulator
A7U43_RS02340	COG1741	Belongs to the pirin family
A7U43_RS02345	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A7U43_RS02350	COG1349	DNA-binding transcription factor activity
A7U43_RS02355	COG1105	Belongs to the carbohydrate kinase PfkB family
A7U43_RS02360	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A7U43_RS02360	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
A7U43_RS02360	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A7U43_RS02370	COG1404	Belongs to the peptidase S8 family
A7U43_RS02400	COG4842	Belongs to the WXG100 family
A7U43_RS02405	COG4842	Belongs to the WXG100 family
A7U43_RS02435	COG0464	growth
A7U43_RS02500	COG2354	Protein conserved in bacteria
A7U43_RS02505	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
A7U43_RS02525	COG3706	GGDEF domain
A7U43_RS02575	COG1716	ATPase activity
A7U43_RS02580	COG1716	ATPase activity
A7U43_RS02595	COG0768	penicillin binding
A7U43_RS02600	COG0515	serine threonine protein kinase
A7U43_RS02605	COG2815	serine threonine protein kinase
A7U43_RS02605	COG0515	serine threonine protein kinase
A7U43_RS02640	COG3119	arylsulfatase activity
A7U43_RS02650	COG0318	PFAM AMP-dependent synthetase and ligase
A7U43_RS02660	COG3835	regulator
A7U43_RS02710	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A7U43_RS02710	COG1372	Participates in initiation and elongation during chromosome replication
A7U43_RS02715	COG0187	DNA topoisomerase II activity
A7U43_RS02720	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
A7U43_RS02725	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A7U43_RS02730	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
A7U43_RS02735	COG0592	DNA-directed DNA polymerase activity
A7U43_RS02750	COG0594	ribonuclease P activity
A7U43_RS02755	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
A7U43_RS02760	COG0706	membrane insertase activity
A7U43_RS02770	COG0357	Ribosomal RNA small subunit methyltransferase G
A7U43_RS02775	COG1192	Involved in chromosome partitioning
A7U43_RS02800	COG0860	N-Acetylmuramoyl-L-alanine amidase
A7U43_RS02800	COG3409	Peptidoglycan-binding domain 1 protein
A7U43_RS02825	COG1595	DNA-templated transcription, initiation
A7U43_RS02870	COG1678	Uncharacterized ACR, COG1678
A7U43_RS02885	COG0495	leucyl-tRNA aminoacylation
A7U43_RS02890	COG0300	oxidoreductase activity
A7U43_RS02895	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
A7U43_RS02905	COG1126	abc transporter atp-binding protein
A7U43_RS02910	COG0765	amino acid transport
A7U43_RS02935	COG0596	Alpha beta hydrolase
A7U43_RS02935	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A7U43_RS02940	COG1309	transcriptional regulator
A7U43_RS02950	COG1260	myo-inositol-1-phosphate synthase
A7U43_RS02975	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A7U43_RS02985	COG0360	Binds together with S18 to 16S ribosomal RNA
A7U43_RS02990	COG0629	single-stranded DNA binding
A7U43_RS02995	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A7U43_RS03000	COG0359	binds to the 23S rRNA
A7U43_RS03045	COG1476	TRANSCRIPTIONal
A7U43_RS03165	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A7U43_RS03170	COG2217	Heavy metal translocating P-type atpase
A7U43_RS03180	COG1376	ErfK ybiS ycfS ynhG family protein
A7U43_RS03185	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A7U43_RS03185	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A7U43_RS03195	COG1845	cytochrome c oxidase, subunit III
A7U43_RS03210	COG1376	ErfK ybiS ycfS ynhG family protein
A7U43_RS03215	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A7U43_RS03215	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A7U43_RS03265	COG0745	RESPONSE REGULATOR receiver
A7U43_RS03270	COG0791	NLP P60 protein
A7U43_RS03270	COG3883	PFAM NLP P60 protein
A7U43_RS03285	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A7U43_RS03305	COG1376	ErfK ybiS ycfS ynhG family protein
A7U43_RS03335	COG1937	Protein conserved in bacteria
A7U43_RS03340	COG2217	Heavy metal translocating P-type atpase
A7U43_RS03405	COG2267	carboxylic ester hydrolase activity
A7U43_RS03425	COG0477	Major facilitator Superfamily
A7U43_RS03430	COG2814	Major facilitator Superfamily
A7U43_RS03440	COG3848	Pyruvate phosphate dikinase
A7U43_RS03440	COG0574	Belongs to the PEP-utilizing enzyme family
A7U43_RS03460	COG3757	hydrolase, family 25
A7U43_RS03465	COG0644	oxidoreductase
A7U43_RS03475	COG3287	FIST C domain
A7U43_RS03475	COG2200	EAL domain
A7U43_RS03475	COG2199	diguanylate cyclase activity
A7U43_RS03495	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A7U43_RS03500	COG1072	(Pantothenic acid kinase))
A7U43_RS03505	COG1609	Transcriptional regulator
A7U43_RS03515	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A7U43_RS03520	COG0187	DNA topoisomerase II activity
A7U43_RS03550	COG0596	Alpha beta hydrolase
A7U43_RS03565	COG3848	Pyruvate phosphate dikinase
A7U43_RS03565	COG0574	Belongs to the PEP-utilizing enzyme family
A7U43_RS03575	COG3011	Protein conserved in bacteria
A7U43_RS03600	COG2030	dehydratase
A7U43_RS03615	COG1309	transcriptional regulator
A7U43_RS03625	COG0477	Major facilitator Superfamily
A7U43_RS03660	COG0038	chloride channel
A7U43_RS03700	COG0488	(ABC) transporter
A7U43_RS03710	COG0702	epimerase
A7U43_RS03745	COG1366	Belongs to the anti-sigma-factor antagonist family
A7U43_RS03785	COG0714	Associated with various cellular activities
A7U43_RS03815	COG1028	Short-chain dehydrogenase reductase Sdr
A7U43_RS03855	COG0723	plastoquinol--plastocyanin reductase activity
A7U43_RS03875	COG4638	Rieske (2fe-2S)
A7U43_RS03900	COG1028	Short-chain dehydrogenase reductase Sdr
A7U43_RS03950	COG0492	ferredoxin-NADP+ reductase activity
A7U43_RS03985	COG2963	transposase activity
A7U43_RS04055	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
A7U43_RS04060	COG1403	HNH endonuclease
A7U43_RS04065	COG1028	Short-chain dehydrogenase reductase Sdr
A7U43_RS04085	COG0714	Associated with various cellular activities
A7U43_RS04100	COG2197	response regulator
A7U43_RS04115	COG3263	regulation of cellular component size
A7U43_RS04160	COG1063	alcohol dehydrogenase
A7U43_RS04175	COG3384	dioxygenase
A7U43_RS04200	COG1643	Atp-dependent helicase
A7U43_RS04210	COG0431	NADPH-dependent FMN reductase
A7U43_RS04215	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A7U43_RS04220	COG1960	acyl-CoA dehydrogenase activity
A7U43_RS04225	COG1960	acyl-CoA dehydrogenase activity
A7U43_RS04250	COG1116	anion transmembrane transporter activity
A7U43_RS04265	COG4044	May play a role in the intracellular transport of hydrophobic ligands
A7U43_RS04335	COG0477	Major facilitator Superfamily
A7U43_RS04340	COG1609	Transcriptional regulator
A7U43_RS04360	COG1022	Amp-dependent synthetase and ligase
A7U43_RS04360	COG3320	Male sterility
A7U43_RS04390	COG3842	ATPase activity
A7U43_RS04395	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
A7U43_RS04410	COG0842	Transport permease protein
A7U43_RS04425	COG1024	Enoyl-CoA hydratase
A7U43_RS04430	COG1335	isochorismatase
A7U43_RS04450	COG0438	transferase activity, transferring glycosyl groups
A7U43_RS04455	COG2226	methyltransferase
A7U43_RS04475	COG1309	transcriptional regulator
A7U43_RS04485	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A7U43_RS04500	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A7U43_RS04505	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
A7U43_RS04515	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A7U43_RS04535	COG0783	Belongs to the Dps family
A7U43_RS04540	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A7U43_RS04550	COG0067	glutamate synthase
A7U43_RS04550	COG0069	glutamate synthase activity
A7U43_RS04550	COG0070	glutamate synthase
A7U43_RS04570	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
A7U43_RS04570	COG1796	DNA polymerase
A7U43_RS04575	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A7U43_RS04580	COG1309	transcriptional regulator
A7U43_RS04585	COG2072	flavoprotein involved in K transport
A7U43_RS04590	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
A7U43_RS04595	COG0789	Transcriptional regulator
A7U43_RS04645	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A7U43_RS04645	COG0425	Belongs to the sulfur carrier protein TusA family
A7U43_RS04660	COG1528	Iron-storage protein
A7U43_RS04665	COG1316	TRANSCRIPTIONal
A7U43_RS04685	COG0077	Prephenate dehydratase
A7U43_RS04705	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
A7U43_RS04710	COG3629	intracellular signal transduction
A7U43_RS04730	COG2146	nitrite reductase [NAD(P)H] activity
A7U43_RS04730	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
A7U43_RS04735	COG0204	Acyl-transferase
A7U43_RS04740	COG0561	phosphatase activity
A7U43_RS04760	COG1216	Glycosyl transferase, family 2
A7U43_RS04765	COG0671	phosphoesterase, PA-phosphatase related
A7U43_RS04770	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
A7U43_RS04775	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
A7U43_RS04785	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
A7U43_RS04800	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
A7U43_RS04805	COG0318	PFAM AMP-dependent synthetase and ligase
A7U43_RS04810	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
A7U43_RS04810	COG3321	synthase
A7U43_RS04810	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A7U43_RS04815	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A7U43_RS04845	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A7U43_RS04865	COG1028	Short-chain dehydrogenase reductase Sdr
A7U43_RS04870	COG0277	FAD linked oxidase domain protein
A7U43_RS04890	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A7U43_RS04900	COG2119	membrane
A7U43_RS04910	COG1403	HNH endonuclease
A7U43_RS04930	COG1216	Glycosyl transferase, family 2
A7U43_RS04955	COG3321	synthase
A7U43_RS04955	COG0604	alcohol dehydrogenase
A7U43_RS04990	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A7U43_RS05005	COG2132	Multicopper oxidase
A7U43_RS05025	COG2015	COG2015, Alkyl sulfatase and related hydrolases
A7U43_RS05030	COG1028	Short-chain dehydrogenase reductase Sdr
A7U43_RS05045	COG5416	Lipopolysaccharide assembly protein A domain
A7U43_RS05060	COG1174	glycine betaine transport
A7U43_RS05075	COG0287	Prephenate dehydrogenase
A7U43_RS05105	COG1063	alcohol dehydrogenase
A7U43_RS05130	COG0343	queuine tRNA-ribosyltransferase activity
A7U43_RS05150	COG0427	acetyl-CoA hydrolase
A7U43_RS05155	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A7U43_RS05155	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
A7U43_RS05165	COG1126	abc transporter atp-binding protein
A7U43_RS05170	COG0765	amino acid transport
A7U43_RS05175	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A7U43_RS05195	COG1793	dna ligase
A7U43_RS05210	COG1793	dna ligase
A7U43_RS05230	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A7U43_RS05250	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A7U43_RS05260	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A7U43_RS05275	COG0860	N-Acetylmuramoyl-L-alanine amidase
A7U43_RS05280	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
A7U43_RS05285	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A7U43_RS05295	COG1492	cobalamin metabolic process
A7U43_RS05300	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A7U43_RS05300	COG1181	Belongs to the D-alanine--D-alanine ligase family
A7U43_RS05310	COG2169	Transcriptional regulator
A7U43_RS05350	COG0069	glutamate synthase activity
A7U43_RS05355	COG2218	PFAM glutamate synthase alpha subunit domain protein
A7U43_RS05360	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
A7U43_RS05425	COG3572	ergothioneine biosynthetic process
A7U43_RS05430	COG1262	PFAM Formylglycine-generating sulfatase enzyme
A7U43_RS05435	COG0121	glutamine amidotransferase
A7U43_RS05440	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
A7U43_RS05445	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A7U43_RS05450	COG1070	Carbohydrate kinase
A7U43_RS05455	COG1940	carbohydrate kinase activity
A7U43_RS05460	COG2115	Belongs to the xylose isomerase family
A7U43_RS05475	COG4214	carbohydrate transport
A7U43_RS05500	COG1454	alcohol dehydrogenase
A7U43_RS05505	COG4585	Histidine kinase
A7U43_RS05530	COG2226	methyltransferase
A7U43_RS05545	COG1695	Transcriptional regulator
A7U43_RS05565	COG0477	Major facilitator Superfamily
A7U43_RS05570	COG1309	transcriptional regulator
A7U43_RS05590	COG0714	Associated with various cellular activities
A7U43_RS05620	COG1946	Acyl-CoA thioesterase
A7U43_RS05645	COG0640	Transcriptional regulator
A7U43_RS05730	COG1960	acyl-CoA dehydrogenase activity
A7U43_RS05750	COG2072	flavoprotein involved in K transport
A7U43_RS05755	COG2072	flavoprotein involved in K transport
A7U43_RS05775	COG1309	transcriptional regulator
A7U43_RS05780	COG1960	acyl-CoA dehydrogenase activity
A7U43_RS05800	COG1024	Enoyl-CoA hydratase
A7U43_RS05805	COG2272	Belongs to the type-B carboxylesterase lipase family
A7U43_RS05835	COG0318	PFAM AMP-dependent synthetase and ligase
A7U43_RS05875	COG1309	transcriptional regulator
A7U43_RS05920	COG4974	Belongs to the 'phage' integrase family
A7U43_RS05930	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A7U43_RS05935	COG1408	metallophosphoesterase
A7U43_RS05940	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
A7U43_RS05970	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A7U43_RS05985	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A7U43_RS05995	COG0494	nUDIX hydrolase
A7U43_RS06020	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A7U43_RS06075	COG1111	helicase
A7U43_RS06075	COG1205	dead DEAH box helicase
A7U43_RS06080	COG1278	Cold shock
A7U43_RS06090	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A7U43_RS06090	COG1754	DNA topoisomerase type I activity
A7U43_RS06100	COG0470	DNA polymerase III
A7U43_RS06120	COG1309	transcriptional regulator
A7U43_RS06135	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A7U43_RS06185	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A7U43_RS06190	COG4948	Mandelate Racemase Muconate Lactonizing
A7U43_RS06200	COG3540	Alkaline phosphatase
A7U43_RS06215	COG0583	DNA-binding transcription factor activity
A7U43_RS06220	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A7U43_RS06225	COG0747	negative chemotaxis
A7U43_RS06230	COG0601	transmembrane transport
A7U43_RS06240	COG0444	Belongs to the ABC transporter superfamily
A7U43_RS06245	COG4608	Belongs to the ABC transporter superfamily
A7U43_RS06265	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A7U43_RS06285	COG2027	D-alanyl-D-alanine carboxypeptidase
A7U43_RS06300	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
A7U43_RS06310	COG2968	Membrane
A7U43_RS06315	COG1063	alcohol dehydrogenase
A7U43_RS06325	COG2267	carboxylic ester hydrolase activity
A7U43_RS06330	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A7U43_RS06335	COG0302	gtp cyclohydrolase
A7U43_RS06385	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
A7U43_RS06440	COG1194	a g-specific adenine glycosylase
A7U43_RS06445	COG0288	reversible hydration of carbon dioxide
A7U43_RS06455	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
A7U43_RS06460	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
A7U43_RS06470	COG1329	Transcriptional regulator
A7U43_RS06475	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
A7U43_RS06480	COG0215	cysteine-tRNA ligase activity
A7U43_RS06485	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A7U43_RS06515	COG0254	rRNA binding
A7U43_RS06530	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A7U43_RS06535	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A7U43_RS06540	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A7U43_RS06545	COG0778	Nitroreductase
A7U43_RS06555	COG0640	Transcriptional regulator
A7U43_RS06565	COG0701	Predicted permease
A7U43_RS06570	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
A7U43_RS06575	COG1121	(ABC) transporter
A7U43_RS06580	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A7U43_RS06585	COG0803	Belongs to the bacterial solute-binding protein 9 family
A7U43_RS06595	COG0523	cobalamin synthesis protein
A7U43_RS06605	COG1121	(ABC) transporter
A7U43_RS06610	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A7U43_RS06615	COG1609	Transcriptional regulator
A7U43_RS06630	COG1309	transcriptional regulator
A7U43_RS06635	COG1960	acyl-CoA dehydrogenase activity
A7U43_RS06655	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A7U43_RS06670	COG0346	lactoylglutathione lyase activity
A7U43_RS06690	COG0583	DNA-binding transcription factor activity
A7U43_RS06700	COG1028	Short-chain dehydrogenase reductase Sdr
A7U43_RS06705	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A7U43_RS06720	COG0436	Aminotransferase
A7U43_RS06725	COG1960	acyl-CoA dehydrogenase activity
A7U43_RS06730	COG1960	acyl-CoA dehydrogenase activity
A7U43_RS06735	COG1960	acyl-CoA dehydrogenase activity
A7U43_RS06740	COG0318	PFAM AMP-dependent synthetase and ligase
A7U43_RS06745	COG1960	acyl-CoA dehydrogenase activity
A7U43_RS06750	COG1028	Short-chain dehydrogenase reductase Sdr
A7U43_RS06760	COG2205	protein histidine kinase activity
A7U43_RS06770	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
A7U43_RS06775	COG1309	transcriptional regulator
A7U43_RS06780	COG0183	Belongs to the thiolase family
A7U43_RS06785	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A7U43_RS06785	COG2080	2 iron, 2 sulfur cluster binding
A7U43_RS06795	COG0402	S-adenosylhomocysteine deaminase activity
A7U43_RS06800	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A7U43_RS06815	COG2233	PERMEase
A7U43_RS06855	COG1024	Enoyl-CoA hydratase
A7U43_RS06860	COG1028	Short-chain dehydrogenase reductase Sdr
A7U43_RS06865	COG1028	Short-chain dehydrogenase reductase Sdr
A7U43_RS06880	COG0406	alpha-ribazole phosphatase activity
A7U43_RS06895	COG0183	Belongs to the thiolase family
A7U43_RS06900	COG2124	cytochrome p450
A7U43_RS06905	COG1960	acyl-CoA dehydrogenase activity
A7U43_RS06910	COG1960	acyl-CoA dehydrogenase activity
A7U43_RS06915	COG2030	dehydratase
A7U43_RS06940	COG2030	dehydratase
A7U43_RS06945	COG1053	succinate dehydrogenase
A7U43_RS06950	COG3971	2-oxopent-4-enoate hydratase activity
A7U43_RS06955	COG4569	acetaldehyde dehydrogenase (acetylating) activity
A7U43_RS06960	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A7U43_RS06965	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A7U43_RS06985	COG0514	ATP-dependent DNA helicase (RecQ)
A7U43_RS07000	COG3290	protein histidine kinase activity
A7U43_RS07015	COG1012	belongs to the aldehyde dehydrogenase family
A7U43_RS07035	COG1028	Short-chain dehydrogenase reductase Sdr
A7U43_RS07050	COG4638	Rieske (2fe-2S)
A7U43_RS07070	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A7U43_RS07085	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A7U43_RS07095	COG2124	cytochrome p450
A7U43_RS07100	COG1846	Transcriptional regulator
A7U43_RS07105	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
A7U43_RS07110	COG0477	Major facilitator Superfamily
A7U43_RS07125	COG2070	2-Nitropropane dioxygenase
A7U43_RS07130	COG1012	belongs to the aldehyde dehydrogenase family
A7U43_RS07135	COG1309	transcriptional regulator
A7U43_RS07155	COG0318	PFAM AMP-dependent synthetase and ligase
A7U43_RS07160	COG1960	acyl-CoA dehydrogenase activity
A7U43_RS07165	COG1960	acyl-CoA dehydrogenase activity
A7U43_RS07175	COG1028	Short-chain dehydrogenase reductase Sdr
A7U43_RS07180	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A7U43_RS07185	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A7U43_RS07210	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
A7U43_RS07230	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
A7U43_RS07265	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
A7U43_RS07265	COG3608	succinylglutamate desuccinylase aspartoacylase
A7U43_RS07285	COG1063	alcohol dehydrogenase
A7U43_RS07290	COG3639	organic phosphonate transmembrane transporter activity
A7U43_RS07295	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
A7U43_RS07300	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
A7U43_RS07310	COG2188	Transcriptional regulator
A7U43_RS07325	COG0745	RESPONSE REGULATOR receiver
A7U43_RS07330	COG2205	protein histidine kinase activity
A7U43_RS07345	COG1028	Short-chain dehydrogenase reductase Sdr
A7U43_RS07370	COG2124	cytochrome p450
A7U43_RS07375	COG4221	oxidoreductase activity
A7U43_RS07390	COG1012	belongs to the aldehyde dehydrogenase family
A7U43_RS07420	COG2124	cytochrome p450
A7U43_RS07440	COG0531	amino acid
A7U43_RS07445	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A7U43_RS07465	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
A7U43_RS07480	COG0386	Belongs to the glutathione peroxidase family
A7U43_RS07490	COG3573	Dehydrogenase
A7U43_RS07505	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A7U43_RS07510	COG0047	phosphoribosylformylglycinamidine synthase activity
A7U43_RS07520	COG2837	iron assimilation
A7U43_RS07525	COG1362	aminopeptidase activity
A7U43_RS07545	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A7U43_RS07580	COG0702	epimerase
A7U43_RS07590	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
A7U43_RS07625	COG2897	thiosulfate sulfurtransferase activity
A7U43_RS07645	COG0745	RESPONSE REGULATOR receiver
A7U43_RS07650	COG0456	acetyltransferase
A7U43_RS07655	COG0640	Transcriptional regulator
A7U43_RS07675	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A7U43_RS07680	COG0798	PFAM Bile acid sodium symporter
A7U43_RS07685	COG0640	Transcriptional regulator
A7U43_RS07690	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A7U43_RS07715	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A7U43_RS07800	COG1233	COG1233 Phytoene dehydrogenase and related
A7U43_RS07810	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A7U43_RS07830	COG1953	Uracil, thiamine, allantoin
A7U43_RS07850	COG4266	Belongs to the allantoicase family
A7U43_RS07895	COG1028	Short-chain dehydrogenase reductase Sdr
A7U43_RS07910	COG0829	nickel cation binding
A7U43_RS07915	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
A7U43_RS07920	COG0804	urea catabolic process
A7U43_RS07925	COG0831	urea catabolic process
A7U43_RS07925	COG0832	Belongs to the urease beta subunit family
A7U43_RS07940	COG1902	pentaerythritol trinitrate reductase activity
A7U43_RS07950	COG0183	Belongs to the thiolase family
A7U43_RS07955	COG1024	Enoyl-CoA hydratase
A7U43_RS07955	COG1250	3-hydroxyacyl-CoA dehydrogenase
A7U43_RS07960	COG4977	sequence-specific DNA binding
A7U43_RS07970	COG2205	protein histidine kinase activity
A7U43_RS07975	COG0745	RESPONSE REGULATOR receiver
A7U43_RS07985	COG2217	Heavy metal translocating P-type atpase
A7U43_RS08000	COG3706	GGDEF domain
A7U43_RS08025	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A7U43_RS08035	COG1028	Short-chain dehydrogenase reductase Sdr
A7U43_RS08040	COG0583	DNA-binding transcription factor activity
A7U43_RS08045	COG4221	oxidoreductase activity
A7U43_RS08060	COG1846	Transcriptional regulator
A7U43_RS08105	COG0521	Mo-molybdopterin cofactor biosynthetic process
A7U43_RS08140	COG0435	Glutathione S-transferase
A7U43_RS08150	COG2814	Major facilitator Superfamily
A7U43_RS08195	COG1403	HNH endonuclease
A7U43_RS08250	COG1309	transcriptional regulator
A7U43_RS08255	COG1309	transcriptional regulator
A7U43_RS08265	COG0477	Major facilitator Superfamily
A7U43_RS08280	COG0545	Peptidyl-prolyl cis-trans isomerase
A7U43_RS08310	COG1132	(ABC) transporter
A7U43_RS08315	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A7U43_RS08320	COG2197	response regulator
A7U43_RS08325	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A7U43_RS08330	COG0318	PFAM AMP-dependent synthetase and ligase
A7U43_RS08340	COG0705	Rhomboid family
A7U43_RS08360	COG0745	RESPONSE REGULATOR receiver
A7U43_RS08370	COG1024	Enoyl-CoA hydratase
A7U43_RS08385	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A7U43_RS08435	COG0183	Belongs to the thiolase family
A7U43_RS08440	COG1595	DNA-templated transcription, initiation
A7U43_RS08445	COG2169	Transcriptional regulator
A7U43_RS08445	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A7U43_RS08450	COG2814	Major facilitator Superfamily
A7U43_RS08465	COG0784	Response regulator, receiver
A7U43_RS08470	COG4251	negative regulation of phosphorylation
A7U43_RS08480	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A7U43_RS08495	COG0753	catalase activity
A7U43_RS08495	COG0693	protein deglycase activity
A7U43_RS08505	COG5343	regulation of RNA biosynthetic process
A7U43_RS08510	COG1595	DNA-templated transcription, initiation
A7U43_RS08515	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A7U43_RS08545	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
A7U43_RS08555	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
A7U43_RS08560	COG1793	dna ligase
A7U43_RS08560	COG3285	dna ligase
A7U43_RS08565	COG1733	regulation of RNA biosynthetic process
A7U43_RS08570	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A7U43_RS08590	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A7U43_RS08605	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A7U43_RS08615	COG1403	HNH endonuclease
A7U43_RS08625	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
A7U43_RS08625	COG2213	PTS system mannitol-specific
A7U43_RS08630	COG1063	alcohol dehydrogenase
A7U43_RS08645	COG0076	glutamate decarboxylase activity
A7U43_RS08650	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A7U43_RS08665	COG1214	PFAM Peptidase M22, glycoprotease
A7U43_RS08665	COG0456	acetyltransferase
A7U43_RS08670	COG0456	acetyltransferase
A7U43_RS08675	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A7U43_RS08710	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
A7U43_RS08725	COG0515	serine threonine protein kinase
A7U43_RS08785	COG0516	GMP reductase activity
A7U43_RS08810	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
A7U43_RS08815	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A7U43_RS08815	COG0519	Catalyzes the synthesis of GMP from XMP
A7U43_RS08835	COG2072	flavoprotein involved in K transport
A7U43_RS08850	COG0657	acetylesterase activity
A7U43_RS08890	COG2030	dehydratase
A7U43_RS08920	COG0587	DNA-directed DNA polymerase activity
A7U43_RS08935	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
A7U43_RS08940	COG2226	methyltransferase
A7U43_RS08950	COG2018	Roadblock/LC7 domain
A7U43_RS08965	COG1357	PFAM Pentapeptide repeats (8 copies)
A7U43_RS08975	COG1960	acyl-CoA dehydrogenase activity
A7U43_RS08980	COG1131	(ABC) transporter
A7U43_RS08980	COG1716	ATPase activity
A7U43_RS08980	COG0842	Transport permease protein
A7U43_RS09015	COG2873	o-acetylhomoserine
A7U43_RS09045	COG1295	ribonuclease BN
A7U43_RS09050	COG2070	2-Nitropropane dioxygenase
A7U43_RS09055	COG1686	Belongs to the peptidase S11 family
A7U43_RS09060	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A7U43_RS09075	COG0183	Belongs to the thiolase family
A7U43_RS09095	COG3804	dihydrodipicolinate reductase
A7U43_RS09135	COG1024	Enoyl-CoA hydratase
A7U43_RS09150	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
A7U43_RS09155	COG0183	Belongs to the thiolase family
A7U43_RS09160	COG2755	lipolytic protein G-D-S-L family
A7U43_RS09165	COG0657	acetylesterase activity
A7U43_RS09175	COG1714	RDD family
A7U43_RS09180	COG5473	translation initiation factor activity
A7U43_RS09210	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
A7U43_RS09220	COG1331	Highly conserved protein containing a thioredoxin domain
A7U43_RS09225	COG3631	Ketosteroid isomerase-related protein
A7U43_RS09235	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A7U43_RS09250	COG0572	uridine kinase
A7U43_RS09260	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A7U43_RS09270	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
A7U43_RS09280	COG0726	polysaccharide deacetylase
A7U43_RS09310	COG1028	Short-chain dehydrogenase reductase Sdr
A7U43_RS09320	COG1262	PFAM Formylglycine-generating sulfatase enzyme
A7U43_RS09330	COG3119	arylsulfatase activity
A7U43_RS09350	COG1722	exodeoxyribonuclease VII activity
A7U43_RS09355	COG1570	exodeoxyribonuclease VII activity
A7U43_RS09380	COG0012	GTP binding
A7U43_RS09385	COG2824	Alkylphosphonate utilization operon protein PhnA
A7U43_RS09415	COG1801	Protein of unknown function DUF72
A7U43_RS09430	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A7U43_RS09445	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A7U43_RS09450	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A7U43_RS09475	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
A7U43_RS09515	COG2186	Transcriptional regulator
A7U43_RS09520	COG0183	Belongs to the thiolase family
A7U43_RS09545	COG4977	sequence-specific DNA binding
A7U43_RS09555	COG0702	epimerase
A7U43_RS09570	COG1024	Enoyl-CoA hydratase
A7U43_RS09575	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A7U43_RS09590	COG1403	HNH endonuclease
A7U43_RS09600	COG2409	Drug exporters of the RND superfamily
A7U43_RS09615	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
A7U43_RS09625	COG2508	Transcriptional regulator
A7U43_RS09630	COG2072	flavoprotein involved in K transport
A7U43_RS09650	COG3467	pyridoxamine 5'-phosphate
A7U43_RS09665	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A7U43_RS09675	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A7U43_RS09685	COG3279	Response regulator of the LytR AlgR family
A7U43_RS09690	COG3275	phosphorelay sensor kinase activity
A7U43_RS09695	COG2860	membrane
A7U43_RS09730	COG1051	belongs to the nudix hydrolase family
A7U43_RS09760	COG1217	gtp-binding protein TYPA
A7U43_RS09765	COG0747	negative chemotaxis
A7U43_RS09775	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
A7U43_RS09800	COG2353	YceI-like domain
A7U43_RS09805	COG0446	pyridine nucleotide-disulphide oxidoreductase
A7U43_RS09805	COG1902	pentaerythritol trinitrate reductase activity
A7U43_RS09815	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
A7U43_RS09830	COG1012	belongs to the aldehyde dehydrogenase family
A7U43_RS09835	COG0506	proline dehydrogenase activity
A7U43_RS09850	COG0318	PFAM AMP-dependent synthetase and ligase
A7U43_RS09860	COG2171	N-acyltransferase activity
A7U43_RS09865	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A7U43_RS09870	COG0488	(ABC) transporter
A7U43_RS09890	COG2755	lipolytic protein G-D-S-L family
A7U43_RS09890	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
A7U43_RS09900	COG1611	Belongs to the LOG family
A7U43_RS09905	COG0318	PFAM AMP-dependent synthetase and ligase
A7U43_RS09915	COG0463	Glycosyl transferase, family 2
A7U43_RS09925	COG0519	Catalyzes the synthesis of GMP from XMP
A7U43_RS09935	COG0297	glycogen (starch) synthase activity
A7U43_RS09940	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
A7U43_RS09960	COG3559	Exporter of polyketide antibiotics
A7U43_RS09965	COG1131	(ABC) transporter
A7U43_RS09970	COG1309	transcriptional regulator
A7U43_RS09980	COG1595	DNA-templated transcription, initiation
A7U43_RS09985	COG5662	AntiSigma factor
A7U43_RS09990	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A7U43_RS09995	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A7U43_RS10015	COG2239	Acts as a magnesium transporter
A7U43_RS10065	COG0598	Magnesium transport protein CorA
A7U43_RS10090	COG0508	dehydrogenase complex catalyzes the overall conversion of
A7U43_RS10090	COG0567	Dehydrogenase, E1 component
A7U43_RS10100	COG2814	Major facilitator Superfamily
A7U43_RS10120	COG0277	FAD linked oxidase domain protein
A7U43_RS10165	COG1132	(ABC) transporter
A7U43_RS10165	COG2375	cellular response to nickel ion
A7U43_RS10170	COG1132	(ABC) transporter
A7U43_RS10185	COG0277	FAD linked oxidase domain protein
A7U43_RS10200	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A7U43_RS10260	COG3383	formate dehydrogenase (NAD+) activity
A7U43_RS10335	COG0745	RESPONSE REGULATOR receiver
A7U43_RS10340	COG2205	protein histidine kinase activity
A7U43_RS10345	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
A7U43_RS10355	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
A7U43_RS10360	COG2814	Major facilitator Superfamily
A7U43_RS10365	COG0175	sulfate reduction
A7U43_RS10375	COG1218	3'(2'),5'-bisphosphate nucleotidase
A7U43_RS10405	COG1914	H( )-stimulated, divalent metal cation uptake system
A7U43_RS10425	COG2217	Heavy metal translocating P-type atpase
A7U43_RS10510	COG0574	Belongs to the PEP-utilizing enzyme family
A7U43_RS10510	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A7U43_RS10525	COG2318	DinB family
A7U43_RS10555	COG2197	response regulator
A7U43_RS10605	COG1309	transcriptional regulator
A7U43_RS10615	COG0018	arginyl-trna synthetase
A7U43_RS10620	COG0019	diaminopimelate decarboxylase activity
A7U43_RS10625	COG0460	homoserine dehydrogenase
A7U43_RS10630	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
A7U43_RS10635	COG0083	homoserine kinase activity
A7U43_RS10645	COG1309	transcriptional regulator
A7U43_RS10650	COG0318	PFAM AMP-dependent synthetase and ligase
A7U43_RS10660	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A7U43_RS10665	COG2890	protein-(glutamine-N5) methyltransferase activity
A7U43_RS10670	COG0009	L-threonylcarbamoyladenylate synthase
A7U43_RS10675	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A7U43_RS10685	COG0356	it plays a direct role in the translocation of protons across the membrane
A7U43_RS10690	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A7U43_RS10695	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A7U43_RS10700	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A7U43_RS10700	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A7U43_RS10705	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
A7U43_RS10710	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A7U43_RS10715	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
A7U43_RS10720	COG0355	proton-transporting ATP synthase activity, rotational mechanism
A7U43_RS10735	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A7U43_RS10775	COG0586	Pfam SNARE associated Golgi protein
A7U43_RS10785	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
A7U43_RS10785	COG2066	Belongs to the glutaminase family
A7U43_RS10795	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
A7U43_RS10805	COG0346	lactoylglutathione lyase activity
A7U43_RS10810	COG0183	Belongs to the thiolase family
A7U43_RS10815	COG2409	Drug exporters of the RND superfamily
A7U43_RS10825	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
A7U43_RS10830	COG0366	Alpha amylase catalytic
A7U43_RS10835	COG0058	SHG alpha-glucan phosphorylase activity
A7U43_RS10860	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
A7U43_RS10875	COG3191	aminopeptidase activity
A7U43_RS10900	COG1234	tRNA 3'-trailer cleavage
A7U43_RS10905	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
A7U43_RS10915	COG2814	Major facilitator Superfamily
A7U43_RS10970	COG1960	acyl-CoA dehydrogenase activity
A7U43_RS10975	COG1960	acyl-CoA dehydrogenase activity
A7U43_RS10985	COG1960	acyl-CoA dehydrogenase activity
A7U43_RS10990	COG1802	Transcriptional regulator
A7U43_RS10995	COG1028	Short-chain dehydrogenase reductase Sdr
A7U43_RS11025	COG1028	Short-chain dehydrogenase reductase Sdr
A7U43_RS11030	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A7U43_RS11030	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A7U43_RS11035	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A7U43_RS11040	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A7U43_RS11045	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A7U43_RS11060	COG0300	oxidoreductase activity
A7U43_RS11070	COG0183	Belongs to the thiolase family
A7U43_RS11075	COG1703	isobutyryl-CoA mutase activity
A7U43_RS11090	COG1024	Enoyl-CoA hydratase
A7U43_RS11100	COG1053	succinate dehydrogenase
A7U43_RS11110	COG2267	carboxylic ester hydrolase activity
A7U43_RS11120	COG3384	dioxygenase
A7U43_RS11125	COG1053	succinate dehydrogenase
A7U43_RS11175	COG0024	Methionine aminopeptidase
A7U43_RS11185	COG1024	Enoyl-CoA hydratase
A7U43_RS11190	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A7U43_RS11205	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A7U43_RS11210	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A7U43_RS11215	COG1028	Short-chain dehydrogenase reductase Sdr
A7U43_RS11230	COG1960	acyl-CoA dehydrogenase activity
A7U43_RS11250	COG4638	Rieske (2fe-2S)
A7U43_RS11265	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A7U43_RS11270	COG1024	Enoyl-CoA hydratase
A7U43_RS11275	COG0183	Belongs to the thiolase family
A7U43_RS11280	COG1960	acyl-CoA dehydrogenase activity
A7U43_RS11325	COG1141	Ferredoxin
A7U43_RS11355	COG2084	Dehydrogenase
A7U43_RS11375	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
A7U43_RS11405	COG1960	acyl-CoA dehydrogenase activity
A7U43_RS11410	COG1960	acyl-CoA dehydrogenase activity
A7U43_RS11435	COG1028	Short-chain dehydrogenase reductase Sdr
A7U43_RS11455	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A7U43_RS11460	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A7U43_RS11485	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
A7U43_RS11515	COG2124	cytochrome p450
A7U43_RS11530	COG1845	cytochrome c oxidase, subunit III
A7U43_RS11545	COG1024	Enoyl-CoA hydratase
A7U43_RS11550	COG0318	PFAM AMP-dependent synthetase and ligase
A7U43_RS11560	COG0318	PFAM AMP-dependent synthetase and ligase
A7U43_RS11575	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
A7U43_RS11580	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
A7U43_RS11635	COG1376	ErfK ybiS ycfS ynhG family protein
A7U43_RS11650	COG1028	Short-chain dehydrogenase reductase Sdr
A7U43_RS11670	COG0433	COG0433 Predicted ATPase
A7U43_RS11695	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A7U43_RS11705	COG1960	acyl-CoA dehydrogenase activity
A7U43_RS11730	COG0508	dehydrogenase complex catalyzes the overall conversion of
A7U43_RS11765	COG4172	Belongs to the ABC transporter superfamily
A7U43_RS11770	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A7U43_RS11780	COG0747	negative chemotaxis
A7U43_RS11790	COG4251	negative regulation of phosphorylation
A7U43_RS11825	COG2937	Belongs to the GPAT DAPAT family
A7U43_RS11850	COG2902	Dehydrogenase
A7U43_RS11865	COG0366	Alpha amylase catalytic
A7U43_RS11885	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
A7U43_RS11900	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
A7U43_RS11905	COG2239	Acts as a magnesium transporter
A7U43_RS11910	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
A7U43_RS11925	COG4221	oxidoreductase activity
A7U43_RS11970	COG0544	peptidyl-prolyl cis-trans isomerase activity
A7U43_RS11980	COG0740	serine-type endopeptidase activity
A7U43_RS11995	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
A7U43_RS12000	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A7U43_RS12010	COG3415	Transposase
A7U43_RS12010	COG2801	Transposase and inactivated derivatives
A7U43_RS12015	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
A7U43_RS12045	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A7U43_RS12050	COG0450	alkyl hydroperoxide reductase
A7U43_RS12055	COG0500	methyltransferase
A7U43_RS12060	COG1937	Protein conserved in bacteria
A7U43_RS12070	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A7U43_RS12075	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A7U43_RS12080	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A7U43_RS12090	COG1082	Xylose isomerase domain protein TIM barrel
A7U43_RS12095	COG0673	inositol 2-dehydrogenase activity
A7U43_RS12105	COG3962	Belongs to the TPP enzyme family
A7U43_RS12120	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A7U43_RS12125	COG2188	Transcriptional regulator
A7U43_RS12135	COG0673	inositol 2-dehydrogenase activity
A7U43_RS12140	COG1609	Transcriptional regulator
A7U43_RS12150	COG1172	Belongs to the binding-protein-dependent transport system permease family
A7U43_RS12170	COG0673	inositol 2-dehydrogenase activity
A7U43_RS12180	COG0673	inositol 2-dehydrogenase activity
A7U43_RS12195	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A7U43_RS12200	COG0674	pyruvate-flavodoxin oxidoreductase activity
A7U43_RS12200	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
A7U43_RS12205	COG1013	pyruvate-flavodoxin oxidoreductase activity
A7U43_RS12210	COG0746	molybdenum cofactor guanylyltransferase activity
A7U43_RS12215	COG1388	LysM domain
A7U43_RS12220	COG1388	LysM domain
A7U43_RS12235	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A7U43_RS12250	COG0004	ammonium transporteR
A7U43_RS12260	COG0823	Involved in the tonB-independent uptake of proteins
A7U43_RS12260	COG1506	peptidase
A7U43_RS12265	COG3268	Saccharopine dehydrogenase
A7U43_RS12275	COG0525	valine-tRNA ligase activity
A7U43_RS12280	COG0285	dihydrofolate synthase activity
A7U43_RS12300	COG1530	ribonuclease E activity
A7U43_RS12310	COG0211	Belongs to the bacterial ribosomal protein bL27 family
A7U43_RS12315	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A7U43_RS12320	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
A7U43_RS12325	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
A7U43_RS12370	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A7U43_RS12375	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
A7U43_RS12380	COG0542	response to heat
A7U43_RS12390	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
A7U43_RS12395	COG0799	negative regulation of ribosome biogenesis
A7U43_RS12400	COG0406	alpha-ribazole phosphatase activity
A7U43_RS12405	COG2755	lipolytic protein G-D-S-L family
A7U43_RS12425	COG0596	Alpha beta hydrolase
A7U43_RS12440	COG2222	sugar isomerase
A7U43_RS12460	COG1486	melibiose metabolic process
A7U43_RS12465	COG2182	Extracellular solute-binding protein
A7U43_RS12475	COG0395	ABC-type sugar transport system, permease component
A7U43_RS12480	COG3842	ATPase activity
A7U43_RS12515	COG1305	Transglutaminase-like
A7U43_RS12530	COG1234	tRNA 3'-trailer cleavage
A7U43_RS12535	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
A7U43_RS12545	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A7U43_RS12555	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A7U43_RS12560	COG1120	ATPase activity
A7U43_RS12580	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A7U43_RS12595	COG3387	PFAM Glycoside hydrolase 15-related
A7U43_RS12610	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
A7U43_RS12620	COG4208	sulfate ABC transporter
A7U43_RS12660	COG1021	2,3-dihydroxybenzoate-AMP ligase
A7U43_RS12675	COG0604	alcohol dehydrogenase
A7U43_RS12675	COG3321	synthase
A7U43_RS12685	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A7U43_RS12725	COG1420	regulation of RNA biosynthetic process
A7U43_RS12730	COG0484	heat shock protein binding
A7U43_RS12745	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
A7U43_RS12775	COG1381	Involved in DNA repair and RecF pathway recombination
A7U43_RS12780	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A7U43_RS12790	COG0494	nUDIX hydrolase
A7U43_RS12805	COG0423	glycine-tRNA ligase activity
A7U43_RS12815	COG0640	Transcriptional regulator
A7U43_RS12830	COG0232	Belongs to the dGTPase family. Type 2 subfamily
A7U43_RS12835	COG0358	DNA primase activity
A7U43_RS12870	COG2409	Drug exporters of the RND superfamily
A7U43_RS12885	COG2814	Major facilitator Superfamily
A7U43_RS12905	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A7U43_RS12960	COG2124	cytochrome p450
A7U43_RS12960	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
A7U43_RS12970	COG1028	Short-chain dehydrogenase reductase Sdr
A7U43_RS13000	COG1305	Transglutaminase-like
A7U43_RS13010	COG2252	PERMEase
A7U43_RS13015	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A7U43_RS13030	COG1028	Short-chain dehydrogenase reductase Sdr
A7U43_RS13075	COG2197	response regulator
A7U43_RS13125	COG1028	Short-chain dehydrogenase reductase Sdr
A7U43_RS13145	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A7U43_RS13150	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A7U43_RS13160	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
A7U43_RS13305	COG2205	protein histidine kinase activity
A7U43_RS13360	COG1396	sequence-specific DNA binding
A7U43_RS13365	COG0492	ferredoxin-NADP+ reductase activity
A7U43_RS13375	COG1403	HNH endonuclease
A7U43_RS13380	COG0346	lactoylglutathione lyase activity
A7U43_RS13385	COG2207	Transcriptional regulator
A7U43_RS13400	COG1024	Enoyl-CoA hydratase
A7U43_RS13430	COG0174	glutamine synthetase
A7U43_RS13435	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
A7U43_RS13440	COG3227	Zinc metalloprotease (Elastase)
A7U43_RS13465	COG2259	Doxx family
A7U43_RS13470	COG0174	glutamine synthetase
A7U43_RS13490	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
A7U43_RS13495	COG0321	lipoyl(octanoyl) transferase activity
A7U43_RS13530	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A7U43_RS13535	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A7U43_RS13540	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
A7U43_RS13545	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
A7U43_RS13550	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
A7U43_RS13580	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A7U43_RS13630	COG1845	cytochrome c oxidase, subunit III
A7U43_RS13635	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A7U43_RS13660	COG0438	transferase activity, transferring glycosyl groups
A7U43_RS13680	COG0003	Pfam Anion-transporting ATPase
A7U43_RS13695	COG5650	phosphatidylinositol metabolic process
A7U43_RS13710	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
A7U43_RS13730	COG0142	geranyltranstransferase activity
A7U43_RS13750	COG2001	Belongs to the MraZ family
A7U43_RS13755	COG0275	rRNA processing
A7U43_RS13765	COG0768	penicillin binding
A7U43_RS13770	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A7U43_RS13790	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A7U43_RS13800	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
A7U43_RS13850	COG0519	Catalyzes the synthesis of GMP from XMP
A7U43_RS13850	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A7U43_RS13865	COG3290	protein histidine kinase activity
A7U43_RS13885	COG0589	response to stress
A7U43_RS13905	COG0583	DNA-binding transcription factor activity
A7U43_RS13910	COG0579	oxidoreductase
A7U43_RS13925	COG0067	glutamate synthase
A7U43_RS13925	COG0069	glutamate synthase activity
A7U43_RS13925	COG0070	glutamate synthase
A7U43_RS13950	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
A7U43_RS13955	COG4988	ABC transporter
A7U43_RS13960	COG1294	oxidase, subunit
A7U43_RS13965	COG1271	oxidase subunit
A7U43_RS13975	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A7U43_RS13995	COG2197	response regulator
A7U43_RS14005	COG0783	Belongs to the Dps family
A7U43_RS14030	COG2205	protein histidine kinase activity
A7U43_RS14035	COG0745	RESPONSE REGULATOR receiver
A7U43_RS14100	COG4974	Belongs to the 'phage' integrase family
A7U43_RS14140	COG1872	DUF167
A7U43_RS14180	COG0702	epimerase
A7U43_RS14195	COG0539	negative regulation of cytoplasmic translation
A7U43_RS14305	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A7U43_RS14375	COG0291	Belongs to the bacterial ribosomal protein bL35 family
A7U43_RS14380	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
A7U43_RS14390	COG1960	acyl-CoA dehydrogenase activity
A7U43_RS14405	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
A7U43_RS14410	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A7U43_RS14410	COG0072	phenylalanine-tRNA ligase activity
A7U43_RS14415	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
A7U43_RS14420	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
A7U43_RS14425	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A7U43_RS14430	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A7U43_RS14435	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A7U43_RS14445	COG0137	argininosuccinate synthase activity
A7U43_RS14450	COG0165	Argininosuccinate lyase
A7U43_RS14475	COG0488	(ABC) transporter
A7U43_RS14490	COG2835	tetraacyldisaccharide 4'-kinase activity
A7U43_RS14505	COG1131	(ABC) transporter
A7U43_RS14540	COG0647	UMP catabolic process
A7U43_RS14595	COG0494	nUDIX hydrolase
A7U43_RS14620	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
A7U43_RS14635	COG1160	GTP binding
A7U43_RS14645	COG0730	response to heat
A7U43_RS14650	COG3046	protein related to deoxyribodipyrimidine photolyase
A7U43_RS14670	COG1755	Isoprenylcysteine carboxyl methyltransferase
A7U43_RS14680	COG0477	Major facilitator Superfamily
A7U43_RS14690	COG1028	Short-chain dehydrogenase reductase Sdr
A7U43_RS14710	COG0667	Aldo Keto reductase
A7U43_RS14715	COG2515	1-aminocyclopropane-1-carboxylate deaminase
A7U43_RS14755	COG5001	Diguanylate cyclase
A7U43_RS14755	COG3300	MHYT domain
A7U43_RS14790	COG0346	lactoylglutathione lyase activity
A7U43_RS14805	COG2814	Major facilitator Superfamily
A7U43_RS14810	COG1115	amino acid carrier protein
A7U43_RS14840	COG1960	acyl-CoA dehydrogenase activity
A7U43_RS14860	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A7U43_RS14860	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A7U43_RS14870	COG1937	Protein conserved in bacteria
A7U43_RS14880	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A7U43_RS14885	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A7U43_RS14920	COG4638	Rieske (2fe-2S)
A7U43_RS14930	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
A7U43_RS14965	COG2814	Major facilitator Superfamily
A7U43_RS14970	COG1012	belongs to the aldehyde dehydrogenase family
A7U43_RS14990	COG1902	pentaerythritol trinitrate reductase activity
A7U43_RS15065	COG2272	Belongs to the type-B carboxylesterase lipase family
A7U43_RS15075	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A7U43_RS15100	COG1053	succinate dehydrogenase
A7U43_RS15100	COG3976	FMN-binding domain protein
A7U43_RS15110	COG0653	protein targeting
A7U43_RS15135	COG0509	glycine decarboxylation via glycine cleavage system
A7U43_RS15140	COG1716	ATPase activity
A7U43_RS15160	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A7U43_RS15160	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A7U43_RS15190	COG1253	flavin adenine dinucleotide binding
A7U43_RS15195	COG1253	flavin adenine dinucleotide binding
A7U43_RS15205	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
A7U43_RS15230	COG0831	urea catabolic process
A7U43_RS15245	COG0830	nickel cation binding
A7U43_RS15255	COG0829	nickel cation binding
A7U43_RS15260	COG1252	NADH dehydrogenase
A7U43_RS15265	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A7U43_RS15295	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A7U43_RS15305	COG0183	Belongs to the thiolase family
A7U43_RS15310	COG0039	L-malate dehydrogenase activity
A7U43_RS15360	COG1252	NADH dehydrogenase
A7U43_RS15405	COG2188	Transcriptional regulator
A7U43_RS15425	COG1024	Enoyl-CoA hydratase
A7U43_RS15450	COG0174	glutamine synthetase
A7U43_RS15495	COG4221	oxidoreductase activity
A7U43_RS15500	COG0438	transferase activity, transferring glycosyl groups
A7U43_RS15540	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A7U43_RS15560	COG1376	ErfK ybiS ycfS ynhG family protein
A7U43_RS15595	COG0243	molybdopterin cofactor binding
A7U43_RS15605	COG2070	2-Nitropropane dioxygenase
A7U43_RS15635	COG3250	beta-galactosidase activity
A7U43_RS15645	COG1058	Belongs to the CinA family
A7U43_RS15645	COG1546	Belongs to the CinA family
A7U43_RS15675	COG0662	Cupin 2, conserved barrel domain protein
A7U43_RS15675	COG2207	Transcriptional regulator
A7U43_RS15705	COG3022	response to hydroperoxide
A7U43_RS15715	COG2186	Transcriptional regulator
A7U43_RS15720	COG2807	transmembrane transport
A7U43_RS15760	COG2755	lipolytic protein G-D-S-L family
A7U43_RS15775	COG4948	Mandelate Racemase Muconate Lactonizing
A7U43_RS15780	COG2124	cytochrome p450
A7U43_RS15795	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
A7U43_RS15815	COG2197	response regulator
A7U43_RS15840	COG0640	Transcriptional regulator
A7U43_RS15910	COG0545	Peptidyl-prolyl cis-trans isomerase
A7U43_RS15945	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
A7U43_RS15950	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A7U43_RS15955	COG2267	carboxylic ester hydrolase activity
A7U43_RS15975	COG4221	oxidoreductase activity
A7U43_RS15985	COG2318	DinB family
A7U43_RS16040	COG2814	Major facilitator Superfamily
A7U43_RS16045	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A7U43_RS16065	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A7U43_RS16115	COG0300	oxidoreductase activity
A7U43_RS16235	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A7U43_RS16240	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A7U43_RS16260	COG4974	Belongs to the 'phage' integrase family
A7U43_RS16270	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A7U43_RS16295	COG1401	restriction endodeoxyribonuclease activity
A7U43_RS16350	COG0415	Belongs to the DNA photolyase family
A7U43_RS16405	COG0596	Alpha beta hydrolase
A7U43_RS16425	COG1176	ABC-type spermidine putrescine transport system, permease component I
A7U43_RS16430	COG1177	transmembrane transport
A7U43_RS16455	COG4585	Histidine kinase
A7U43_RS16460	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
A7U43_RS16460	COG0778	Nitroreductase
A7U43_RS16475	COG3265	gluconokinase activity
A7U43_RS16490	COG1742	UPF0060 membrane protein
A7U43_RS16505	COG2272	Belongs to the type-B carboxylesterase lipase family
A7U43_RS16520	COG0745	RESPONSE REGULATOR receiver
A7U43_RS16535	COG0463	Glycosyl transferase, family 2
A7U43_RS16545	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A7U43_RS16625	COG0300	oxidoreductase activity
A7U43_RS16650	COG4581	dead DEAH box helicase
A7U43_RS16660	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A7U43_RS16665	COG2378	regulation of single-species biofilm formation
A7U43_RS16675	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
A7U43_RS16680	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
A7U43_RS16685	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
A7U43_RS16695	COG4122	O-methyltransferase activity
A7U43_RS16700	COG5285	phytanoyl-CoA dioxygenase
A7U43_RS16710	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A7U43_RS16715	COG0456	acetyltransferase
A7U43_RS16720	COG0745	RESPONSE REGULATOR receiver
A7U43_RS16785	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A7U43_RS16795	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
A7U43_RS16800	COG0140	phosphoribosyl-ATP diphosphatase activity
A7U43_RS16805	COG0477	Major facilitator Superfamily
A7U43_RS16815	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A7U43_RS16820	COG0702	epimerase
A7U43_RS16825	COG1410	methionine synthase
A7U43_RS16825	COG0646	methionine synthase
A7U43_RS16835	COG1028	Short-chain dehydrogenase reductase Sdr
A7U43_RS16840	COG0215	cysteine-tRNA ligase activity
A7U43_RS16870	COG1968	undecaprenyl-diphosphatase activity
A7U43_RS16900	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A7U43_RS16915	COG0129	dihydroxy-acid dehydratase activity
A7U43_RS16925	COG0243	molybdopterin cofactor binding
A7U43_RS16930	COG2223	nitrite transmembrane transporter activity
A7U43_RS16940	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A7U43_RS16945	COG2146	nitrite reductase [NAD(P)H] activity
A7U43_RS16960	COG0159	tryptophan synthase activity
A7U43_RS16970	COG0134	indole-3-glycerol-phosphate synthase activity
A7U43_RS16980	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A7U43_RS16990	COG1119	ATPase activity
A7U43_RS17005	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
A7U43_RS17010	COG0107	imidazoleglycerol-phosphate synthase activity
A7U43_RS17015	COG0483	inositol monophosphate 1-phosphatase activity
A7U43_RS17020	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
A7U43_RS17025	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
A7U43_RS17030	COG0131	Imidazoleglycerol-phosphate dehydratase
A7U43_RS17035	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A7U43_RS17050	COG1280	lysine exporter protein (LysE YggA)
A7U43_RS17065	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
A7U43_RS17095	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A7U43_RS17115	COG0156	8-amino-7-oxononanoate synthase activity
A7U43_RS17185	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
A7U43_RS17215	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
A7U43_RS17220	COG0252	asparaginase activity
A7U43_RS17230	COG2501	S4 domain
A7U43_RS17235	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A7U43_RS17265	COG0318	PFAM AMP-dependent synthetase and ligase
A7U43_RS17285	COG0604	alcohol dehydrogenase
A7U43_RS17285	COG1028	Short-chain dehydrogenase reductase Sdr
A7U43_RS17285	COG3321	synthase
A7U43_RS17290	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A7U43_RS17335	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
A7U43_RS17340	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A7U43_RS17350	COG2207	Transcriptional regulator
A7U43_RS17355	COG0667	Aldo Keto reductase
A7U43_RS17360	COG2304	oxidoreductase activity
A7U43_RS17370	COG0714	Associated with various cellular activities
A7U43_RS17380	COG3883	PFAM NLP P60 protein
A7U43_RS17380	COG0791	NLP P60 protein
A7U43_RS17390	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
A7U43_RS17395	COG1309	transcriptional regulator
A7U43_RS17405	COG0488	(ABC) transporter
A7U43_RS17415	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A7U43_RS17420	COG2151	metal-sulfur cluster biosynthetic enzyme
A7U43_RS17435	COG0396	ATPase activity
A7U43_RS17480	COG1349	DNA-binding transcription factor activity
A7U43_RS17485	COG0483	inositol monophosphate 1-phosphatase activity
A7U43_RS17490	COG0434	BtpA family
A7U43_RS17515	COG0395	ABC-type sugar transport system, permease component
A7U43_RS17520	COG3842	ATPase activity
A7U43_RS17545	COG0109	protoheme IX farnesyltransferase activity
A7U43_RS17555	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A7U43_RS17590	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
A7U43_RS17605	COG0149	triose-phosphate isomerase activity
A7U43_RS17610	COG0126	phosphoglycerate kinase activity
A7U43_RS17615	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A7U43_RS17620	COG1481	regulation of sporulation
A7U43_RS17630	COG1660	Displays ATPase and GTPase activities
A7U43_RS17635	COG0322	excinuclease ABC activity
A7U43_RS17640	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A7U43_RS17645	COG1365	unkown
A7U43_RS17655	COG0456	acetyltransferase
A7U43_RS17665	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
A7U43_RS17670	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A7U43_RS17670	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A7U43_RS17700	COG0477	Major facilitator Superfamily
A7U43_RS17725	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A7U43_RS17730	COG1704	LemA family
A7U43_RS17740	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A7U43_RS17750	COG0657	acetylesterase activity
A7U43_RS17760	COG0469	pyruvate kinase activity
A7U43_RS17765	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A7U43_RS17775	COG1758	RNA polymerase activity
A7U43_RS17795	COG0284	orotidine-5'-phosphate decarboxylase activity
A7U43_RS17800	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A7U43_RS17805	COG0505	Belongs to the CarA family
A7U43_RS17820	COG0540	Belongs to the ATCase OTCase family
A7U43_RS17825	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
A7U43_RS17845	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A7U43_RS17860	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A7U43_RS17880	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A7U43_RS17895	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A7U43_RS17900	COG0432	Pfam Uncharacterised protein family UPF0047
A7U43_RS17950	COG1733	regulation of RNA biosynthetic process
A7U43_RS17955	COG0183	Belongs to the thiolase family
A7U43_RS17975	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
A7U43_RS17990	COG2272	Belongs to the type-B carboxylesterase lipase family
A7U43_RS18005	COG1946	Acyl-CoA thioesterase
A7U43_RS18015	COG1960	acyl-CoA dehydrogenase activity
A7U43_RS18020	COG1960	acyl-CoA dehydrogenase activity
A7U43_RS18035	COG2235	arginine
A7U43_RS18040	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A7U43_RS18070	COG0683	leucine binding
A7U43_RS18085	COG0411	ABC transporter
A7U43_RS18095	COG1490	D-aminoacyl-tRNA deacylase activity
A7U43_RS18105	COG0124	histidyl-tRNA synthetase
A7U43_RS18110	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A7U43_RS18115	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A7U43_RS18120	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A7U43_RS18130	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A7U43_RS18135	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A7U43_RS18140	COG0747	negative chemotaxis
A7U43_RS18145	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A7U43_RS18165	COG5001	Diguanylate cyclase
A7U43_RS18180	COG2255	four-way junction helicase activity
A7U43_RS18185	COG0632	four-way junction helicase activity
A7U43_RS18200	COG0217	transcriptional regulatory protein
A7U43_RS18205	COG1309	transcriptional regulator
A7U43_RS18215	COG1960	acyl-CoA dehydrogenase activity
A7U43_RS18220	COG0300	oxidoreductase activity
A7U43_RS18225	COG1309	transcriptional regulator
A7U43_RS18230	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
A7U43_RS18235	COG1946	Acyl-CoA thioesterase
A7U43_RS18240	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
A7U43_RS18245	COG1051	belongs to the nudix hydrolase family
A7U43_RS18250	COG0438	transferase activity, transferring glycosyl groups
A7U43_RS18255	COG1560	Kdo2-lipid A biosynthetic process
A7U43_RS18260	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A7U43_RS18270	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A7U43_RS18285	COG4762	Protein conserved in bacteria
A7U43_RS18295	COG1960	acyl-CoA dehydrogenase activity
A7U43_RS18300	COG1960	acyl-CoA dehydrogenase activity
A7U43_RS18310	COG0058	SHG alpha-glucan phosphorylase activity
A7U43_RS18315	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
A7U43_RS18455	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A7U43_RS18465	COG2226	methyltransferase
A7U43_RS18515	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A7U43_RS18525	COG3253	May function as heme-dependent peroxidase
A7U43_RS18535	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
A7U43_RS18560	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A7U43_RS18585	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A7U43_RS18590	COG0531	amino acid
A7U43_RS18595	COG0569	domain protein
A7U43_RS18625	COG0756	dUTP diphosphatase activity
A7U43_RS18645	COG0483	inositol monophosphate 1-phosphatase activity
A7U43_RS18665	COG1028	Short-chain dehydrogenase reductase Sdr
A7U43_RS18745	COG1388	LysM domain
A7U43_RS18750	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
A7U43_RS18760	COG1960	acyl-CoA dehydrogenase activity
A7U43_RS18770	COG1309	transcriptional regulator
A7U43_RS18775	COG1960	acyl-CoA dehydrogenase activity
A7U43_RS18790	COG5651	PPE family
A7U43_RS18790	COG3391	amine dehydrogenase activity
A7U43_RS18795	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A7U43_RS18800	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
A7U43_RS18815	COG0697	spore germination
A7U43_RS18820	COG1196	nuclear chromosome segregation
A7U43_RS18830	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A7U43_RS18835	COG1126	abc transporter atp-binding protein
A7U43_RS18840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A7U43_RS18845	COG0765	amino acid transport
A7U43_RS18850	COG0765	amino acid transport
A7U43_RS18855	COG2814	Major facilitator Superfamily
A7U43_RS18865	COG1309	transcriptional regulator
A7U43_RS18870	COG1028	Short-chain dehydrogenase reductase Sdr
A7U43_RS18875	COG2137	regulation of response to DNA damage stimulus
A7U43_RS18880	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
A7U43_RS18900	COG4308	Limonene-1,2-epoxide hydrolase catalytic domain
A7U43_RS18915	COG1842	Phage shock protein A
A7U43_RS18920	COG1396	sequence-specific DNA binding
A7U43_RS18930	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
A7U43_RS18935	COG1674	ftsk spoiiie
A7U43_RS18940	COG0659	secondary active sulfate transmembrane transporter activity
A7U43_RS18960	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
A7U43_RS18965	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A7U43_RS18975	COG1028	Short-chain dehydrogenase reductase Sdr
A7U43_RS18985	COG3214	Protein conserved in bacteria
A7U43_RS18995	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
A7U43_RS19085	COG0309	Hydrogenase expression formation protein (HypE)
A7U43_RS19090	COG0409	Hydrogenase expression formation protein
A7U43_RS19095	COG0298	carbon dioxide binding
A7U43_RS19105	COG0375	protein maturation
A7U43_RS19120	COG1522	sequence-specific DNA binding
A7U43_RS19125	COG0686	Belongs to the AlaDH PNT family
A7U43_RS19140	COG1185	polyribonucleotide nucleotidyltransferase activity
A7U43_RS19150	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
A7U43_RS19175	COG0318	PFAM AMP-dependent synthetase and ligase
A7U43_RS19180	COG2267	carboxylic ester hydrolase activity
A7U43_RS19185	COG1960	acyl-CoA dehydrogenase activity
A7U43_RS19190	COG1028	Short-chain dehydrogenase reductase Sdr
A7U43_RS19205	COG0183	Belongs to the thiolase family
A7U43_RS19215	COG0791	NLP P60 protein
A7U43_RS19215	COG3883	PFAM NLP P60 protein
A7U43_RS19225	COG2205	protein histidine kinase activity
A7U43_RS19230	COG0745	RESPONSE REGULATOR receiver
A7U43_RS19235	COG1012	belongs to the aldehyde dehydrogenase family
A7U43_RS19250	COG3391	amine dehydrogenase activity
A7U43_RS19250	COG5651	PPE family
A7U43_RS19260	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
A7U43_RS19270	COG2977	Belongs to the P-Pant transferase superfamily
A7U43_RS19275	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
A7U43_RS19300	COG1024	Enoyl-CoA hydratase
A7U43_RS19305	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
A7U43_RS19310	COG1929	Belongs to the glycerate kinase type-1 family
A7U43_RS19325	COG0673	inositol 2-dehydrogenase activity
A7U43_RS19330	COG1609	Transcriptional regulator
A7U43_RS19335	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A7U43_RS19340	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A7U43_RS19345	COG1116	anion transmembrane transporter activity
A7U43_RS19355	COG0534	Mate efflux family protein
A7U43_RS19360	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
A7U43_RS19375	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
A7U43_RS19385	COG0195	Participates in both transcription termination and antitermination
A7U43_RS19390	COG0779	Required for maturation of 30S ribosomal subunits
A7U43_RS19405	COG0442	prolyl-tRNA aminoacylation
A7U43_RS19425	COG1648	precorrin-2 dehydrogenase activity
A7U43_RS19425	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A7U43_RS19465	COG1122	ATPase activity
A7U43_RS19480	COG0310	cobalt ion transport
A7U43_RS19530	COG2186	Transcriptional regulator
A7U43_RS19535	COG1028	Short-chain dehydrogenase reductase Sdr
A7U43_RS19540	COG1012	belongs to the aldehyde dehydrogenase family
A7U43_RS19545	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
A7U43_RS19585	COG0768	penicillin binding
A7U43_RS19590	COG0456	acetyltransferase
A7U43_RS19595	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
A7U43_RS19600	COG0750	zinc metalloprotease
A7U43_RS19605	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
A7U43_RS19625	COG0531	amino acid
A7U43_RS19635	COG2826	transposase and inactivated derivatives, IS30 family
A7U43_RS19670	COG1063	alcohol dehydrogenase
A7U43_RS19735	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A7U43_RS19745	COG3328	transposase activity
A7U43_RS19775	COG0528	UMP kinase activity
A7U43_RS19805	COG1136	(ABC) transporter
A7U43_RS19820	COG0154	amidase activity
A7U43_RS19825	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
A7U43_RS19830	COG0052	Belongs to the universal ribosomal protein uS2 family
A7U43_RS19910	COG3842	ATPase activity
A7U43_RS19915	COG0318	PFAM AMP-dependent synthetase and ligase
A7U43_RS19925	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A7U43_RS19950	COG0681	Belongs to the peptidase S26 family
A7U43_RS19955	COG0335	large ribosomal subunit rRNA binding
A7U43_RS19995	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A7U43_RS19995	COG0189	ligase activity
A7U43_RS20000	COG0367	asparagine synthase
A7U43_RS20005	COG1686	Belongs to the peptidase S11 family
A7U43_RS20010	COG1686	Belongs to the peptidase S11 family
A7U43_RS20015	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
A7U43_RS20025	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A7U43_RS20035	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
A7U43_RS20055	COG1304	FMN binding
A7U43_RS20070	COG1845	cytochrome c oxidase, subunit III
A7U43_RS20090	COG1196	nuclear chromosome segregation
A7U43_RS20095	COG1254	Belongs to the acylphosphatase family
A7U43_RS20110	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A7U43_RS20115	COG0571	ribonuclease III activity
A7U43_RS20125	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A7U43_RS20135	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A7U43_RS20155	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
A7U43_RS20160	COG0742	ribosomal rna small subunit methyltransferase
A7U43_RS20180	COG0657	acetylesterase activity
A7U43_RS20185	COG0656	L-ascorbic acid biosynthetic process
A7U43_RS20190	COG0656	L-ascorbic acid biosynthetic process
A7U43_RS20215	COG1309	transcriptional regulator
A7U43_RS20225	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A7U43_RS20225	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A7U43_RS20230	COG1376	ErfK ybiS ycfS ynhG family protein
A7U43_RS20245	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
A7U43_RS20245	COG4124	Belongs to the glycosyl hydrolase 26 family
A7U43_RS20255	COG1215	transferase activity, transferring glycosyl groups
A7U43_RS20260	COG1366	Belongs to the anti-sigma-factor antagonist family
A7U43_RS20290	COG1461	Dihydroxyacetone kinase
A7U43_RS20300	COG2801	Transposase and inactivated derivatives
A7U43_RS20305	COG2963	transposase activity
A7U43_RS20340	COG0626	cystathionine gamma-synthase activity
A7U43_RS20350	COG1920	GTP binding
A7U43_RS20355	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
A7U43_RS20375	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A7U43_RS20405	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A7U43_RS20410	COG0179	Fumarylacetoacetate (FAA) hydrolase
A7U43_RS20415	COG2271	Major facilitator Superfamily
A7U43_RS20420	COG0450	alkyl hydroperoxide reductase
A7U43_RS20425	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A7U43_RS20435	COG0473	3-isopropylmalate dehydrogenase activity
A7U43_RS20460	COG0440	acetolactate synthase activity
A7U43_RS20485	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A7U43_RS20505	COG0205	6-phosphofructokinase activity
A7U43_RS20510	COG0028	Belongs to the TPP enzyme family
A7U43_RS20520	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A7U43_RS20545	COG3766	membrane
A7U43_RS20560	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A7U43_RS20570	COG0596	Alpha beta hydrolase
A7U43_RS20575	COG0318	PFAM AMP-dependent synthetase and ligase
A7U43_RS20610	COG2826	transposase and inactivated derivatives, IS30 family
A7U43_RS20615	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
A7U43_RS20625	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A7U43_RS20650	COG0110	maltose O-acetyltransferase activity
A7U43_RS20655	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A7U43_RS20685	COG1119	ATPase activity
A7U43_RS20690	COG2364	Membrane
A7U43_RS20695	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A7U43_RS20700	COG0560	Phosphoserine phosphatase
A7U43_RS20700	COG3830	Belongs to the UPF0237 family
A7U43_RS20720	COG1064	alcohol dehydrogenase
A7U43_RS20735	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
A7U43_RS20740	COG2080	2 iron, 2 sulfur cluster binding
A7U43_RS20745	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A7U43_RS20755	COG2197	response regulator
A7U43_RS20780	COG2801	Transposase and inactivated derivatives
A7U43_RS20820	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A7U43_RS20835	COG1309	transcriptional regulator
A7U43_RS20850	COG0583	DNA-binding transcription factor activity
A7U43_RS20880	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A7U43_RS20895	COG1228	amidohydrolase
A7U43_RS20995	COG1140	nitrate reductase beta subunit
A7U43_RS21015	COG1966	Carbon starvation protein
A7U43_RS21025	COG4221	oxidoreductase activity
A7U43_RS21035	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A7U43_RS21060	COG1309	transcriptional regulator
A7U43_RS21065	COG2072	flavoprotein involved in K transport
A7U43_RS21075	COG1028	Short-chain dehydrogenase reductase Sdr
A7U43_RS21100	COG1012	belongs to the aldehyde dehydrogenase family
A7U43_RS21105	COG2124	cytochrome p450
A7U43_RS21120	COG1028	Short-chain dehydrogenase reductase Sdr
A7U43_RS21125	COG1012	belongs to the aldehyde dehydrogenase family
A7U43_RS21135	COG0183	Belongs to the thiolase family
A7U43_RS21145	COG1960	acyl-CoA dehydrogenase activity
A7U43_RS21155	COG1960	acyl-CoA dehydrogenase activity
A7U43_RS21180	COG1024	Enoyl-CoA hydratase
A7U43_RS21190	COG1024	Enoyl-CoA hydratase
A7U43_RS21205	COG1024	Enoyl-CoA hydratase
A7U43_RS21210	COG2188	Transcriptional regulator
A7U43_RS21215	COG1024	Enoyl-CoA hydratase
A7U43_RS21220	COG1024	Enoyl-CoA hydratase
A7U43_RS21225	COG1024	Enoyl-CoA hydratase
A7U43_RS21235	COG0318	PFAM AMP-dependent synthetase and ligase
A7U43_RS21245	COG4221	oxidoreductase activity
A7U43_RS21250	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A7U43_RS21260	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A7U43_RS21285	COG2072	flavoprotein involved in K transport
A7U43_RS21290	COG1802	Transcriptional regulator
A7U43_RS21295	COG1960	acyl-CoA dehydrogenase activity
A7U43_RS21300	COG0183	Belongs to the thiolase family
A7U43_RS21310	COG1960	acyl-CoA dehydrogenase activity
A7U43_RS21340	COG1672	PFAM Archaeal ATPase
A7U43_RS21340	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
A7U43_RS21350	COG1960	acyl-CoA dehydrogenase activity
A7U43_RS21355	COG1960	acyl-CoA dehydrogenase activity
A7U43_RS21365	COG0753	catalase activity
A7U43_RS21400	COG0318	PFAM AMP-dependent synthetase and ligase
A7U43_RS21415	COG2124	cytochrome p450
A7U43_RS21420	COG1309	transcriptional regulator
A7U43_RS21425	COG0412	Dienelactone hydrolase
A7U43_RS21450	COG1309	transcriptional regulator
A7U43_RS21455	COG2267	carboxylic ester hydrolase activity
A7U43_RS21470	COG0477	Major facilitator Superfamily
A7U43_RS21500	COG1993	acr, cog1993
A7U43_RS21540	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
A7U43_RS21545	COG0363	glucosamine-6-phosphate deaminase activity
A7U43_RS21550	COG2190	(PTS) system
A7U43_RS21550	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A7U43_RS21550	COG1263	PTS System
A7U43_RS21555	COG2190	(PTS) system
A7U43_RS21555	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A7U43_RS21555	COG1263	PTS System
A7U43_RS21560	COG1605	Chorismate mutase
A7U43_RS21565	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
A7U43_RS21600	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
A7U43_RS21605	COG0668	transmembrane transport
A7U43_RS21610	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
A7U43_RS21820	COG0420	3'-5' exonuclease activity
A7U43_RS21825	COG0419	ATPase involved in DNA repair
A7U43_RS21835	COG1061	Type III restriction enzyme res subunit
A7U43_RS21840	COG0514	ATP-dependent DNA helicase (RecQ)
A7U43_RS21845	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A7U43_RS21860	COG2963	transposase activity
A7U43_RS21895	COG4942	peptidase
A7U43_RS21900	COG3177	Filamentation induced by cAMP protein fic
A7U43_RS21910	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A7U43_RS21945	COG1309	transcriptional regulator
A7U43_RS22020	COG2124	cytochrome p450
A7U43_RS22035	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
A7U43_RS22040	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
A7U43_RS22065	COG2801	Transposase and inactivated derivatives
A7U43_RS22115	COG5001	Diguanylate cyclase
A7U43_RS22120	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
A7U43_RS22125	COG2177	Part of the ABC transporter FtsEX involved in
A7U43_RS22130	COG2884	Cell division ATP-binding protein ftsE
A7U43_RS22140	COG0668	transmembrane transport
A7U43_RS22145	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A7U43_RS22165	COG0483	inositol monophosphate 1-phosphatase activity
A7U43_RS22175	COG1960	acyl-CoA dehydrogenase activity
A7U43_RS22185	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
A7U43_RS22195	COG1960	acyl-CoA dehydrogenase activity
A7U43_RS22200	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
A7U43_RS22215	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A7U43_RS22220	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A7U43_RS22255	COG2353	YceI-like domain
A7U43_RS22275	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A7U43_RS22280	COG0649	NAD binding
A7U43_RS22295	COG1034	ATP synthesis coupled electron transport
A7U43_RS22305	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A7U43_RS22315	COG0713	ATP synthesis coupled electron transport
A7U43_RS22335	COG1024	Enoyl-CoA hydratase
A7U43_RS22365	COG2072	flavoprotein involved in K transport
A7U43_RS22410	COG0318	PFAM AMP-dependent synthetase and ligase
A7U43_RS22475	COG1309	transcriptional regulator
A7U43_RS22505	COG3158	transport of potassium into the cell
A7U43_RS22530	COG1028	Short-chain dehydrogenase reductase Sdr
A7U43_RS22535	COG1408	metallophosphoesterase
A7U43_RS22540	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A7U43_RS22545	COG0235	Class ii aldolase
A7U43_RS22550	COG3620	sequence-specific DNA binding
A7U43_RS22555	COG3622	Belongs to the hyi family
A7U43_RS22575	COG1295	ribonuclease BN
A7U43_RS22580	COG1309	transcriptional regulator
A7U43_RS22590	COG1309	transcriptional regulator
A7U43_RS22595	COG2357	RelA SpoT domain protein
A7U43_RS22635	COG1615	UPF0182 protein
A7U43_RS22640	COG3480	Lon protease (S16) C-terminal proteolytic domain
A7U43_RS22655	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
A7U43_RS22675	COG3284	Transcriptional regulator
A7U43_RS22680	COG0145	ligase activity
A7U43_RS22690	COG0145	ligase activity
A7U43_RS22695	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
A7U43_RS22720	COG0183	Belongs to the thiolase family
A7U43_RS22730	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A7U43_RS22750	COG0596	Alpha beta hydrolase
A7U43_RS22755	COG3695	enzyme binding
A7U43_RS22795	COG0513	Belongs to the DEAD box helicase family
A7U43_RS22810	COG0406	alpha-ribazole phosphatase activity
A7U43_RS22835	COG1960	acyl-CoA dehydrogenase activity
A7U43_RS22840	COG1960	acyl-CoA dehydrogenase activity
A7U43_RS22845	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A7U43_RS22850	COG0583	DNA-binding transcription factor activity
A7U43_RS22855	COG3012	SEC-C Motif Domain Protein
A7U43_RS22865	COG1597	lipid kinase activity
A7U43_RS22880	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
A7U43_RS22885	COG5662	AntiSigma factor
A7U43_RS22890	COG1595	DNA-templated transcription, initiation
A7U43_RS22895	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A7U43_RS22920	COG2135	peptidase activity
A7U43_RS22930	COG1162	GTPase activity
A7U43_RS22950	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A7U43_RS22970	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
A7U43_RS22975	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
A7U43_RS22980	COG4221	oxidoreductase activity
A7U43_RS22985	COG5401	PFAM Sporulation and spore germination
A7U43_RS22990	COG5002	protein histidine kinase activity
A7U43_RS22995	COG0745	RESPONSE REGULATOR receiver
A7U43_RS23020	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
A7U43_RS23035	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A7U43_RS23050	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A7U43_RS23075	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
A7U43_RS23075	COG0778	Nitroreductase
A7U43_RS23105	COG1316	TRANSCRIPTIONal
A7U43_RS23125	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
A7U43_RS23130	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
A7U43_RS23185	COG0489	protein tyrosine kinase activity
A7U43_RS23210	COG0110	maltose O-acetyltransferase activity
A7U43_RS23215	COG0438	transferase activity, transferring glycosyl groups
A7U43_RS23220	COG4638	Rieske (2fe-2S)
A7U43_RS23230	COG0318	PFAM AMP-dependent synthetase and ligase
A7U43_RS23235	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A7U43_RS23270	COG4770	biotin carboxylase activity
A7U43_RS23285	COG1366	Belongs to the anti-sigma-factor antagonist family
A7U43_RS23310	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A7U43_RS23315	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A7U43_RS23350	COG0640	Transcriptional regulator
A7U43_RS23370	COG1522	sequence-specific DNA binding
A7U43_RS23380	COG1012	belongs to the aldehyde dehydrogenase family
A7U43_RS23390	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A7U43_RS23395	COG1028	Short-chain dehydrogenase reductase Sdr
A7U43_RS23400	COG2072	flavoprotein involved in K transport
A7U43_RS23415	COG1028	Short-chain dehydrogenase reductase Sdr
A7U43_RS23430	COG0318	PFAM AMP-dependent synthetase and ligase
A7U43_RS23440	COG0318	PFAM AMP-dependent synthetase and ligase
A7U43_RS23450	COG0346	lactoylglutathione lyase activity
A7U43_RS23465	COG1201	RNA secondary structure unwinding
A7U43_RS23490	COG1309	transcriptional regulator
A7U43_RS23510	COG0564	pseudouridine synthase activity
A7U43_RS23535	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
A7U43_RS23535	COG1473	amidohydrolase
A7U43_RS23550	COG1309	transcriptional regulator
A7U43_RS23565	COG3180	Ammonia monooxygenase
A7U43_RS23575	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A7U43_RS23620	COG2009	succinate dehydrogenase
A7U43_RS23635	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A7U43_RS23655	COG1595	DNA-templated transcription, initiation
A7U43_RS23690	COG4565	transcriptional regulatory protein
A7U43_RS23695	COG3290	protein histidine kinase activity
A7U43_RS23700	COG1301	dicarboxylic acid transport
A7U43_RS23710	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A7U43_RS23710	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A7U43_RS23720	COG1126	abc transporter atp-binding protein
A7U43_RS23725	COG0765	amino acid transport
A7U43_RS23760	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A7U43_RS23835	COG1752	Esterase of the alpha-beta hydrolase superfamily
A7U43_RS23885	COG0235	Class ii aldolase
A7U43_RS23910	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
A7U43_RS23915	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
A7U43_RS23920	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
A7U43_RS23955	COG2826	transposase and inactivated derivatives, IS30 family
A7U43_RS23960	COG2217	Heavy metal translocating P-type atpase
A7U43_RS23965	COG0640	Transcriptional regulator
A7U43_RS24005	COG2822	iron ion transport
A7U43_RS24015	COG2826	transposase and inactivated derivatives, IS30 family
A7U43_RS24020	COG3956	TIGRFAM MazG family protein
A7U43_RS24030	COG1309	transcriptional regulator
A7U43_RS24065	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
A7U43_RS24070	COG0193	aminoacyl-tRNA hydrolase activity
A7U43_RS24090	COG0318	PFAM AMP-dependent synthetase and ligase
A7U43_RS24095	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
A7U43_RS24105	COG3583	domain protein
A7U43_RS24110	COG0084	hydrolase, TatD family'
A7U43_RS24130	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A7U43_RS24185	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A7U43_RS24190	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A7U43_RS24190	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A7U43_RS24235	COG1028	Short-chain dehydrogenase reductase Sdr
A7U43_RS24245	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A7U43_RS24250	COG0318	PFAM AMP-dependent synthetase and ligase
A7U43_RS24290	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A7U43_RS24295	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A7U43_RS24335	COG0521	Mo-molybdopterin cofactor biosynthetic process
A7U43_RS24335	COG0315	cyclic pyranopterin monophosphate synthase activity
A7U43_RS24340	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A7U43_RS24350	COG0745	RESPONSE REGULATOR receiver
A7U43_RS24365	COG1960	acyl-CoA dehydrogenase activity
A7U43_RS24370	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A7U43_RS24385	COG1024	Enoyl-CoA hydratase
A7U43_RS24465	COG0045	succinate-CoA ligase (ADP-forming) activity
A7U43_RS24495	COG0166	Belongs to the GPI family
A7U43_RS24515	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A7U43_RS24520	COG1950	PFAM Membrane protein of
A7U43_RS24545	COG2814	Major facilitator Superfamily
A7U43_RS24560	COG0142	geranyltranstransferase activity
A7U43_RS24590	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
A7U43_RS24620	COG0328	RNA-DNA hybrid ribonuclease activity
A7U43_RS24630	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A7U43_RS24640	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A7U43_RS24645	COG0513	Belongs to the DEAD box helicase family
A7U43_RS24670	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A7U43_RS24675	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
A7U43_RS24685	COG4303	Ethanolamine ammonia lyase large subunit
A7U43_RS24690	COG0531	amino acid
A7U43_RS24725	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A7U43_RS24725	COG1648	precorrin-2 dehydrogenase activity
A7U43_RS24730	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A7U43_RS24740	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A7U43_RS24760	COG4842	Belongs to the WXG100 family
A7U43_RS24765	COG4842	Belongs to the WXG100 family
A7U43_RS24785	COG1404	Belongs to the peptidase S8 family
A7U43_RS24800	COG5006	permease, DMT superfamily
A7U43_RS24840	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A7U43_RS24845	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
A7U43_RS24850	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A7U43_RS24855	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A7U43_RS24860	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A7U43_RS24900	COG0492	ferredoxin-NADP+ reductase activity
A7U43_RS24905	COG3852	Histidine kinase
A7U43_RS24920	COG1088	dTDP-glucose 4,6-dehydratase activity
A7U43_RS24925	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
A7U43_RS24955	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A7U43_RS24965	COG1960	acyl-CoA dehydrogenase activity
A7U43_RS25020	COG0563	adenylate kinase activity
A7U43_RS25030	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
A7U43_RS25035	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
A7U43_RS25045	COG1366	Belongs to the anti-sigma-factor antagonist family
A7U43_RS25060	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
A7U43_RS25075	COG0616	signal peptide processing
A7U43_RS25080	COG0200	Binds to the 23S rRNA
A7U43_RS25085	COG1841	ribosomal large subunit assembly
A7U43_RS25090	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
A7U43_RS25095	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
A7U43_RS25100	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A7U43_RS25105	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A7U43_RS25110	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A7U43_RS25115	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
A7U43_RS25125	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
A7U43_RS25135	COG0405	Gamma-glutamyltransferase
A7U43_RS25145	COG1012	belongs to the aldehyde dehydrogenase family
A7U43_RS25175	COG2814	Major facilitator Superfamily
A7U43_RS25180	COG3069	C4-dicarboxylate transmembrane transporter activity
A7U43_RS25185	COG3619	membrane
A7U43_RS25220	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
A7U43_RS25230	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
A7U43_RS25235	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
A7U43_RS25240	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
A7U43_RS25245	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A7U43_RS25250	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
A7U43_RS25260	COG0088	Forms part of the polypeptide exit tunnel
A7U43_RS25265	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
A7U43_RS25270	COG0051	transcription antitermination factor activity, RNA binding
A7U43_RS25280	COG2272	Belongs to the type-B carboxylesterase lipase family
A7U43_RS25295	COG0477	Major facilitator Superfamily
A7U43_RS25325	COG0535	radical SAM domain protein
A7U43_RS25355	COG1522	sequence-specific DNA binding
A7U43_RS25360	COG1834	amidinotransferase
A7U43_RS25365	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A7U43_RS25375	COG2235	arginine
A7U43_RS25400	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A7U43_RS25405	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A7U43_RS25420	COG1309	transcriptional regulator
A7U43_RS25450	COG1024	Enoyl-CoA hydratase
A7U43_RS25465	COG1960	acyl-CoA dehydrogenase activity
A7U43_RS25480	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
A7U43_RS25490	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A7U43_RS25495	COG0085	RNA polymerase activity
A7U43_RS25505	COG0222	ribosome binding
A7U43_RS25510	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
A7U43_RS25515	COG1012	belongs to the aldehyde dehydrogenase family
A7U43_RS25580	COG0659	secondary active sulfate transmembrane transporter activity
A7U43_RS25595	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A7U43_RS25600	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A7U43_RS25625	COG0489	protein tyrosine kinase activity
A7U43_RS25630	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A7U43_RS25630	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
A7U43_RS25640	COG2942	2-epimerase
A7U43_RS25645	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
A7U43_RS25675	COG0859	PFAM glycosyl transferase family 9
A7U43_RS25690	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A7U43_RS25705	COG0081	regulation of translation
A7U43_RS25710	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A7U43_RS25720	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A7U43_RS25735	COG2030	dehydratase
A7U43_RS25745	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A7U43_RS25770	COG1959	2 iron, 2 sulfur cluster binding
A7U43_RS25775	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A7U43_RS25815	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
A7U43_RS25820	COG1074	ATP-dependent DNA helicase activity
A7U43_RS25825	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A7U43_RS25835	COG0789	Transcriptional regulator
A7U43_RS25840	COG0659	secondary active sulfate transmembrane transporter activity
A7U43_RS25845	COG1262	PFAM Formylglycine-generating sulfatase enzyme
A7U43_RS25850	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
A7U43_RS25940	COG3311	Transcriptional regulator
A7U43_RS26000	COG1666	GTP binding
A7U43_RS26015	COG0501	Belongs to the peptidase M48B family
A7U43_RS26020	COG0142	geranyltranstransferase activity
A7U43_RS26025	COG0644	oxidoreductase
A7U43_RS26030	COG3123	guanosine phosphorylase activity
A7U43_RS26045	COG4221	oxidoreductase activity
A7U43_RS26050	COG2814	Major facilitator Superfamily
A7U43_RS26055	COG0438	transferase activity, transferring glycosyl groups
A7U43_RS26070	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
A7U43_RS26085	COG4977	sequence-specific DNA binding
A7U43_RS26090	COG4948	Mandelate Racemase Muconate Lactonizing
A7U43_RS26100	COG1228	amidohydrolase
A7U43_RS26110	COG0318	PFAM AMP-dependent synthetase and ligase
A7U43_RS26120	COG4941	Belongs to the sigma-70 factor family
A7U43_RS26130	COG4552	Acetyltransferase involved in intracellular survival and related
A7U43_RS26165	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
A7U43_RS26170	COG4221	oxidoreductase activity
A7U43_RS26225	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
A7U43_RS26245	COG2070	2-Nitropropane dioxygenase
A7U43_RS26280	COG0745	RESPONSE REGULATOR receiver
A7U43_RS26285	COG5002	protein histidine kinase activity
A7U43_RS26290	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A7U43_RS26295	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
A7U43_RS26325	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A7U43_RS26335	COG0785	Cytochrome C biogenesis protein
A7U43_RS26345	COG0406	alpha-ribazole phosphatase activity
A7U43_RS26350	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
A7U43_RS26375	COG1403	HNH endonuclease
A7U43_RS26405	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A7U43_RS26410	COG0181	hydroxymethylbilane synthase activity
A7U43_RS26430	COG2030	dehydratase
A7U43_RS26480	COG0745	RESPONSE REGULATOR receiver
A7U43_RS26485	COG5002	protein histidine kinase activity
A7U43_RS26500	COG0438	transferase activity, transferring glycosyl groups
A7U43_RS26565	COG2733	membrane
A7U43_RS26575	COG2326	polyphosphate kinase activity
A7U43_RS26580	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A7U43_RS26630	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A7U43_RS26640	COG1505	serine-type exopeptidase activity
A7U43_RS26645	COG1301	dicarboxylic acid transport
A7U43_RS26685	COG2326	polyphosphate kinase activity
A7U43_RS26690	COG1012	belongs to the aldehyde dehydrogenase family
A7U43_RS26720	COG0459	protein refolding
A7U43_RS26730	COG1028	Short-chain dehydrogenase reductase Sdr
A7U43_RS26750	COG3383	formate dehydrogenase (NAD+) activity
A7U43_RS26755	COG0647	UMP catabolic process
A7U43_RS26770	COG1028	Short-chain dehydrogenase reductase Sdr
A7U43_RS26780	COG0688	phosphatidylethanolamine metabolic process
A7U43_RS26790	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A7U43_RS26805	COG2111	Na H antiporter
A7U43_RS26805	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A7U43_RS26810	COG1006	Multisubunit Na H antiporter MnhC subunit
A7U43_RS26815	COG0651	ATP synthesis coupled electron transport
A7U43_RS26825	COG2212	antiporter activity
A7U43_RS26830	COG1320	monovalent cation:proton antiporter activity
A7U43_RS26845	COG2032	superoxide dismutase activity
A7U43_RS26895	COG2226	methyltransferase
A7U43_RS26905	COG2814	Major facilitator Superfamily
A7U43_RS26910	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
A7U43_RS26955	COG1024	Enoyl-CoA hydratase
A7U43_RS26965	COG1028	Short-chain dehydrogenase reductase Sdr
A7U43_RS26970	COG1012	belongs to the aldehyde dehydrogenase family
A7U43_RS26980	COG2233	PERMEase
A7U43_RS26985	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A7U43_RS27000	COG2409	Drug exporters of the RND superfamily
A7U43_RS27010	COG2234	aminopeptidase activity
A7U43_RS27015	COG2234	aminopeptidase activity
A7U43_RS27025	COG1131	(ABC) transporter
A7U43_RS27035	COG2022	thiamine diphosphate biosynthetic process
A7U43_RS27045	COG2022	thiamine diphosphate biosynthetic process
A7U43_RS27045	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A7U43_RS27050	COG0352	thiamine-phosphate diphosphorylase activity
A7U43_RS27065	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A7U43_RS27070	COG0515	serine threonine protein kinase
A7U43_RS27075	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
A7U43_RS27100	COG1028	Short-chain dehydrogenase reductase Sdr
A7U43_RS27105	COG2188	Transcriptional regulator
A7U43_RS27110	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A7U43_RS27115	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A7U43_RS27120	COG2226	methyltransferase
A7U43_RS27135	COG4221	oxidoreductase activity
A7U43_RS27140	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A7U43_RS27150	COG0583	DNA-binding transcription factor activity
A7U43_RS27175	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
A7U43_RS27190	COG2409	Drug exporters of the RND superfamily
A7U43_RS27195	COG2267	carboxylic ester hydrolase activity
A7U43_RS27200	COG2124	cytochrome p450
A7U43_RS27225	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
A7U43_RS27235	COG1994	Peptidase M50
A7U43_RS27260	COG4221	oxidoreductase activity
A7U43_RS27305	COG3415	Transposase
A7U43_RS27305	COG2801	Transposase and inactivated derivatives
A7U43_RS27320	COG0586	Pfam SNARE associated Golgi protein
A7U43_RS27330	COG0477	Major facilitator Superfamily
A7U43_RS27335	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A7U43_RS27335	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A7U43_RS27365	COG0542	response to heat
A7U43_RS27410	COG0789	Transcriptional regulator
A7U43_RS27415	COG0484	heat shock protein binding
A7U43_RS27420	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A7U43_RS27425	COG0443	Heat shock 70 kDa protein
A7U43_RS27430	COG2267	carboxylic ester hydrolase activity
A7U43_RS27450	COG4399	Belongs to the UPF0754 family
A7U43_RS27510	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A7U43_RS27550	COG2181	nitrate reductase activity
A7U43_RS27550	COG0247	lactate metabolic process
A7U43_RS27600	COG0717	Belongs to the dCTP deaminase family
A7U43_RS27635	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A7U43_RS27640	COG3550	peptidyl-serine autophosphorylation
A7U43_RS27675	COG0247	lactate metabolic process
A7U43_RS27675	COG2181	nitrate reductase activity
A7U43_RS27840	COG3387	PFAM Glycoside hydrolase 15-related
A7U43_RS28105	COG1674	ftsk spoiiie
A7U43_RS28165	COG1960	acyl-CoA dehydrogenase activity
A7U43_RS28255	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A7U43_RS28270	COG2144	transferase activity, transferring acyl groups
A7U43_RS28695	COG3321	synthase
A7U43_RS28695	COG0604	alcohol dehydrogenase
A7U43_RS28830	COG4981	capsule polysaccharide biosynthetic process
A7U43_RS28835	COG4981	capsule polysaccharide biosynthetic process
A7U43_RS28840	COG4981	capsule polysaccharide biosynthetic process