locus-tag	class	description
RN05_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
RN05_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
RN05_RS00020	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
RN05_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
RN05_RS00105	COG0631	protein serine/threonine phosphatase activity
RN05_RS00105	COG3266	domain, Protein
RN05_RS00115	COG1716	ATPase activity
RN05_RS00185	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
RN05_RS00240	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RN05_RS00245	COG0596	Alpha beta hydrolase
RN05_RS00245	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
RN05_RS00250	COG1260	myo-inositol-1-phosphate synthase
RN05_RS00270	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
RN05_RS00310	COG1372	Participates in initiation and elongation during chromosome replication
RN05_RS00310	COG0305	Participates in initiation and elongation during chromosome replication
RN05_RS00340	COG0277	FAD linked oxidase domain protein
RN05_RS00345	COG1615	UPF0182 protein
RN05_RS00365	COG1309	transcriptional regulator
RN05_RS00370	COG1028	Short-chain dehydrogenase reductase Sdr
RN05_RS00385	COG3344	reverse transcriptase
RN05_RS00400	COG1228	amidohydrolase
RN05_RS00420	COG1309	transcriptional regulator
RN05_RS00450	COG3260	NADH ubiquinone oxidoreductase 20
RN05_RS00460	COG0650	Formate hydrogenlyase subunit 4
RN05_RS00470	COG0651	ATP synthesis coupled electron transport
RN05_RS00475	COG3261	NADH dehydrogenase
RN05_RS00475	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
RN05_RS00515	COG1403	HNH endonuclease
RN05_RS00545	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
RN05_RS00555	COG2217	Heavy metal translocating P-type atpase
RN05_RS00575	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
RN05_RS00585	COG0657	acetylesterase activity
RN05_RS00595	COG2755	lipolytic protein G-D-S-L family
RN05_RS00595	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
RN05_RS00625	COG1376	ErfK ybiS ycfS ynhG family protein
RN05_RS00630	COG0583	DNA-binding transcription factor activity
RN05_RS00635	COG0028	Belongs to the TPP enzyme family
RN05_RS00645	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
RN05_RS00670	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RN05_RS00680	COG3281	Trehalose synthase
RN05_RS00705	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RN05_RS00715	COG0596	Alpha beta hydrolase
RN05_RS00760	COG0038	chloride channel
RN05_RS00765	COG1309	transcriptional regulator
RN05_RS00780	COG1012	belongs to the aldehyde dehydrogenase family
RN05_RS00785	COG1028	Short-chain dehydrogenase reductase Sdr
RN05_RS00790	COG3321	synthase
RN05_RS00790	COG1028	Short-chain dehydrogenase reductase Sdr
RN05_RS00790	COG0604	alcohol dehydrogenase
RN05_RS00810	COG2365	Tyrosine phosphatase family
RN05_RS00845	COG1309	transcriptional regulator
RN05_RS00850	COG5651	PPE family
RN05_RS00850	COG0657	acetylesterase activity
RN05_RS00855	COG5651	PPE family
RN05_RS00855	COG0657	acetylesterase activity
RN05_RS00860	COG0277	FAD linked oxidase domain protein
RN05_RS00865	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
RN05_RS00880	COG1802	Transcriptional regulator
RN05_RS00890	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
RN05_RS00895	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
RN05_RS00920	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
RN05_RS00970	COG2267	carboxylic ester hydrolase activity
RN05_RS00985	COG1472	Belongs to the glycosyl hydrolase 3 family
RN05_RS00995	COG4122	O-methyltransferase activity
RN05_RS01010	COG1937	Protein conserved in bacteria
RN05_RS01015	COG2814	Major facilitator Superfamily
RN05_RS01020	COG1376	ErfK ybiS ycfS ynhG family protein
RN05_RS01030	COG1132	(ABC) transporter
RN05_RS01045	COG0243	molybdopterin cofactor binding
RN05_RS01050	COG3590	peptidase
RN05_RS01090	COG2409	Drug exporters of the RND superfamily
RN05_RS01145	COG0657	acetylesterase activity
RN05_RS01150	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
RN05_RS01160	COG0657	acetylesterase activity
RN05_RS01170	COG1024	Enoyl-CoA hydratase
RN05_RS01180	COG0500	methyltransferase
RN05_RS01185	COG0297	glycogen (starch) synthase activity
RN05_RS01205	COG1487	ribonuclease activity
RN05_RS01230	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
RN05_RS01245	COG4981	capsule polysaccharide biosynthetic process
RN05_RS01255	COG1472	Belongs to the glycosyl hydrolase 3 family
RN05_RS01275	COG2030	dehydratase
RN05_RS01285	COG0183	Belongs to the thiolase family
RN05_RS01290	COG1960	acyl-CoA dehydrogenase activity
RN05_RS01310	COG1053	succinate dehydrogenase
RN05_RS01330	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
RN05_RS01330	COG2146	nitrite reductase [NAD(P)H] activity
RN05_RS01385	COG1984	allophanate hydrolase subunit 2
RN05_RS01405	COG2223	nitrite transmembrane transporter activity
RN05_RS01410	COG2161	toxin-antitoxin pair type II binding
RN05_RS01420	COG0318	PFAM AMP-dependent synthetase and ligase
RN05_RS01425	COG1960	acyl-CoA dehydrogenase activity
RN05_RS01440	COG0346	lactoylglutathione lyase activity
RN05_RS01475	COG5651	PPE family
RN05_RS01495	COG1674	ftsk spoiiie
RN05_RS01495	COG1672	PFAM Archaeal ATPase
RN05_RS01530	COG1404	Belongs to the peptidase S8 family
RN05_RS01555	COG1368	sulfuric ester hydrolase activity
RN05_RS01560	COG3391	amine dehydrogenase activity
RN05_RS01605	COG0778	Nitroreductase
RN05_RS01615	COG0671	phosphoesterase, PA-phosphatase related
RN05_RS01685	COG0717	Belongs to the dCTP deaminase family
RN05_RS01690	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
RN05_RS01695	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
RN05_RS01710	COG2226	methyltransferase
RN05_RS01725	COG2226	methyltransferase
RN05_RS01735	COG1252	NADH dehydrogenase
RN05_RS01770	COG0247	lactate metabolic process
RN05_RS01770	COG2181	nitrate reductase activity
RN05_RS01845	COG0789	Transcriptional regulator
RN05_RS01870	COG1994	Peptidase M50
RN05_RS01885	COG2239	Acts as a magnesium transporter
RN05_RS01930	COG0746	molybdenum cofactor guanylyltransferase activity
RN05_RS01970	COG3360	Dodecin
RN05_RS02015	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
RN05_RS02030	COG1252	NADH dehydrogenase
RN05_RS02035	COG1403	HNH endonuclease
RN05_RS02075	COG1960	acyl-CoA dehydrogenase activity
RN05_RS02105	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RN05_RS02130	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RN05_RS02160	COG2022	thiamine diphosphate biosynthetic process
RN05_RS02165	COG2234	aminopeptidase activity
RN05_RS02200	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
RN05_RS02255	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
RN05_RS02260	COG1183	phosphatidylcholine synthase activity
RN05_RS02275	COG1028	Short-chain dehydrogenase reductase Sdr
RN05_RS02300	COG5343	regulation of RNA biosynthetic process
RN05_RS02315	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
RN05_RS02360	COG1024	Enoyl-CoA hydratase
RN05_RS02365	COG2337	Toxic component of a toxin-antitoxin (TA) module
RN05_RS02375	COG1505	serine-type exopeptidase activity
RN05_RS02435	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
RN05_RS02460	COG2733	membrane
RN05_RS02645	COG1033	growth of symbiont in host cell
RN05_RS02645	COG2409	Drug exporters of the RND superfamily
RN05_RS02665	COG1648	precorrin-2 dehydrogenase activity
RN05_RS02665	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
RN05_RS02690	COG1366	Belongs to the anti-sigma-factor antagonist family
RN05_RS02695	COG2755	lipolytic protein G-D-S-L family
RN05_RS02695	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
RN05_RS02700	COG2755	lipolytic protein G-D-S-L family
RN05_RS02720	COG1113	amino acid transport
RN05_RS02735	COG0406	alpha-ribazole phosphatase activity
RN05_RS02745	COG0785	Cytochrome C biogenesis protein
RN05_RS02755	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
RN05_RS02775	COG3391	amine dehydrogenase activity
RN05_RS02790	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
RN05_RS02795	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RN05_RS02840	COG0306	phosphate transporter
RN05_RS02850	COG4221	oxidoreductase activity
RN05_RS02870	COG0318	PFAM AMP-dependent synthetase and ligase
RN05_RS02875	COG1228	amidohydrolase
RN05_RS02925	COG0142	geranyltranstransferase activity
RN05_RS02940	COG2072	flavoprotein involved in K transport
RN05_RS02955	COG2345	Transcriptional regulator
RN05_RS02970	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
RN05_RS03030	COG2402	Toxic component of a toxin-antitoxin (TA) module. An RNase
RN05_RS03060	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
RN05_RS03085	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
RN05_RS03095	COG1487	ribonuclease activity
RN05_RS03115	COG2002	toxin-antitoxin pair type II binding
RN05_RS03125	COG2972	Histidine kinase
RN05_RS03130	COG0745	RESPONSE REGULATOR receiver
RN05_RS03195	COG0653	protein targeting
RN05_RS03230	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
RN05_RS03270	COG1487	ribonuclease activity
RN05_RS03290	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
RN05_RS03335	COG2030	dehydratase
RN05_RS03365	COG0081	regulation of translation
RN05_RS03370	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
RN05_RS03375	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
RN05_RS03380	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
RN05_RS03385	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
RN05_RS03425	COG1309	transcriptional regulator
RN05_RS03500	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
RN05_RS03525	COG1960	acyl-CoA dehydrogenase activity
RN05_RS03540	COG1024	Enoyl-CoA hydratase
RN05_RS03545	COG1033	growth of symbiont in host cell
RN05_RS03545	COG2409	Drug exporters of the RND superfamily
RN05_RS03555	COG1510	regulation of RNA biosynthetic process
RN05_RS03570	COG1309	transcriptional regulator
RN05_RS03630	COG0535	radical SAM domain protein
RN05_RS03735	COG1262	PFAM Formylglycine-generating sulfatase enzyme
RN05_RS03790	COG0200	Binds to the 23S rRNA
RN05_RS03795	COG0616	signal peptide processing
RN05_RS03810	COG0235	Class ii aldolase
RN05_RS03815	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
RN05_RS03885	COG0657	acetylesterase activity
RN05_RS03955	COG0406	alpha-ribazole phosphatase activity
RN05_RS03980	COG0745	RESPONSE REGULATOR receiver
RN05_RS03985	COG2205	protein histidine kinase activity
RN05_RS04020	COG1028	Short-chain dehydrogenase reductase Sdr
RN05_RS04080	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
RN05_RS04115	COG0477	Major facilitator Superfamily
RN05_RS04125	COG3573	Dehydrogenase
RN05_RS04140	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
RN05_RS04160	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RN05_RS04165	COG2188	Transcriptional regulator
RN05_RS04170	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
RN05_RS04175	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RN05_RS04180	COG2963	transposase activity
RN05_RS04185	COG2801	Transposase and inactivated derivatives
RN05_RS04190	COG3547	Transposase (IS116 IS110 IS902 family)
RN05_RS04200	COG2837	iron assimilation
RN05_RS04205	COG1362	aminopeptidase activity
RN05_RS04250	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
RN05_RS04295	COG0745	RESPONSE REGULATOR receiver
RN05_RS04340	COG0640	Transcriptional regulator
RN05_RS04345	COG0590	tRNA wobble adenosine to inosine editing
RN05_RS04385	COG3391	amine dehydrogenase activity
RN05_RS04435	COG4106	trans-aconitate 2-methyltransferase activity
RN05_RS04440	COG0596	Alpha beta hydrolase
RN05_RS04455	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
RN05_RS04465	COG4585	Histidine kinase
RN05_RS04470	COG2132	Multicopper oxidase
RN05_RS04480	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
RN05_RS04515	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RN05_RS04535	COG0183	Belongs to the thiolase family
RN05_RS04540	COG1250	3-hydroxyacyl-CoA dehydrogenase
RN05_RS04540	COG1024	Enoyl-CoA hydratase
RN05_RS04565	COG0521	Mo-molybdopterin cofactor biosynthetic process
RN05_RS04590	COG3304	Inner membrane component domain
RN05_RS04595	COG1278	Cold shock
RN05_RS04645	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RN05_RS04695	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
RN05_RS04820	COG0183	Belongs to the thiolase family
RN05_RS04860	COG3328	transposase activity
RN05_RS04910	COG0581	inorganic phosphate transmembrane transporter activity
RN05_RS04950	COG3285	dna ligase
RN05_RS04950	COG1793	dna ligase
RN05_RS04980	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
RN05_RS05015	COG0739	heme binding
RN05_RS05020	COG0045	succinate-CoA ligase (ADP-forming) activity
RN05_RS05125	COG1024	Enoyl-CoA hydratase
RN05_RS05140	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
RN05_RS05160	COG3391	amine dehydrogenase activity
RN05_RS05180	COG0745	RESPONSE REGULATOR receiver
RN05_RS05190	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RN05_RS05195	COG0521	Mo-molybdopterin cofactor biosynthetic process
RN05_RS05195	COG0315	cyclic pyranopterin monophosphate synthase activity
RN05_RS05200	COG1970	mechanosensitive ion channel activity
RN05_RS05210	COG0577	efflux transmembrane transporter activity
RN05_RS05220	COG0142	geranyltranstransferase activity
RN05_RS05235	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
RN05_RS05240	COG1210	Utp--glucose-1-phosphate uridylyltransferase
RN05_RS05275	COG4106	trans-aconitate 2-methyltransferase activity
RN05_RS05280	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RN05_RS05280	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
RN05_RS05315	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
RN05_RS05325	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RN05_RS05330	COG0084	hydrolase, TatD family'
RN05_RS05355	COG0318	PFAM AMP-dependent synthetase and ligase
RN05_RS05400	COG3956	TIGRFAM MazG family protein
RN05_RS05435	COG2205	protein histidine kinase activity
RN05_RS05465	COG2205	protein histidine kinase activity
RN05_RS05470	COG0745	RESPONSE REGULATOR receiver
RN05_RS05510	COG2801	Transposase and inactivated derivatives
RN05_RS05515	COG2963	transposase activity
RN05_RS05520	COG0657	acetylesterase activity
RN05_RS05540	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RN05_RS05560	COG3328	transposase activity
RN05_RS05580	COG1028	Short-chain dehydrogenase reductase Sdr
RN05_RS05625	COG3391	amine dehydrogenase activity
RN05_RS05630	COG0318	PFAM AMP-dependent synthetase and ligase
RN05_RS05710	COG0183	Belongs to the thiolase family
RN05_RS05715	COG2755	lipolytic protein G-D-S-L family
RN05_RS05720	COG0657	acetylesterase activity
RN05_RS05760	COG1331	Highly conserved protein containing a thioredoxin domain
RN05_RS05785	COG0657	acetylesterase activity
RN05_RS05820	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
RN05_RS05830	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
RN05_RS05875	COG2272	Belongs to the type-B carboxylesterase lipase family
RN05_RS05915	COG0012	GTP binding
RN05_RS05970	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
RN05_RS05980	COG0596	Alpha beta hydrolase
RN05_RS05995	COG0574	Belongs to the PEP-utilizing enzyme family
RN05_RS05995	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
RN05_RS06000	COG1403	HNH endonuclease
RN05_RS06005	COG1396	sequence-specific DNA binding
RN05_RS06005	COG3800	Transcriptional regulator
RN05_RS06040	COG0183	Belongs to the thiolase family
RN05_RS06060	COG1755	Isoprenylcysteine carboxyl methyltransferase
RN05_RS06070	COG1024	Enoyl-CoA hydratase
RN05_RS06075	COG1024	Enoyl-CoA hydratase
RN05_RS06080	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RN05_RS06135	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
RN05_RS06145	COG3467	pyridoxamine 5'-phosphate
RN05_RS06190	COG1140	nitrate reductase beta subunit
RN05_RS06205	COG1217	gtp-binding protein TYPA
RN05_RS06255	COG1902	pentaerythritol trinitrate reductase activity
RN05_RS06255	COG0446	pyridine nucleotide-disulphide oxidoreductase
RN05_RS06265	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
RN05_RS06280	COG1028	Short-chain dehydrogenase reductase Sdr
RN05_RS06280	COG3321	synthase
RN05_RS06280	COG0604	alcohol dehydrogenase
RN05_RS06295	COG5651	PPE family
RN05_RS06305	COG2508	Transcriptional regulator
RN05_RS06305	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
RN05_RS06310	COG1012	belongs to the aldehyde dehydrogenase family
RN05_RS06315	COG0506	proline dehydrogenase activity
RN05_RS06325	COG0596	Alpha beta hydrolase
RN05_RS06340	COG0318	PFAM AMP-dependent synthetase and ligase
RN05_RS06350	COG0657	acetylesterase activity
RN05_RS06355	COG5651	PPE family
RN05_RS06360	COG4842	Belongs to the WXG100 family
RN05_RS06370	COG3328	transposase activity
RN05_RS06375	COG0477	Major facilitator Superfamily
RN05_RS06400	COG1611	Belongs to the LOG family
RN05_RS06405	COG0318	PFAM AMP-dependent synthetase and ligase
RN05_RS06430	COG0519	Catalyzes the synthesis of GMP from XMP
RN05_RS06465	COG3559	Exporter of polyketide antibiotics
RN05_RS06470	COG1131	(ABC) transporter
RN05_RS06475	COG1309	transcriptional regulator
RN05_RS06490	COG5662	AntiSigma factor
RN05_RS06495	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RN05_RS06500	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
RN05_RS06540	COG2239	Acts as a magnesium transporter
RN05_RS06575	COG0598	Magnesium transport protein CorA
RN05_RS06610	COG2026	Addiction module toxin, RelE StbE family
RN05_RS06615	COG2161	toxin-antitoxin pair type II binding
RN05_RS06620	COG0567	Dehydrogenase, E1 component
RN05_RS06620	COG0508	dehydrogenase complex catalyzes the overall conversion of
RN05_RS06665	COG0277	FAD linked oxidase domain protein
RN05_RS06900	COG2890	protein-(glutamine-N5) methyltransferase activity
RN05_RS07015	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
RN05_RS07015	COG2972	Histidine kinase
RN05_RS07020	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
RN05_RS07030	COG0346	lactoylglutathione lyase activity
RN05_RS07060	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
RN05_RS07070	COG0058	SHG alpha-glucan phosphorylase activity
RN05_RS07080	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
RN05_RS07120	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
RN05_RS07245	COG5651	PPE family
RN05_RS07260	COG1366	Belongs to the anti-sigma-factor antagonist family
RN05_RS07260	COG2172	sigma factor antagonist activity
RN05_RS07260	COG2208	phosphoserine phosphatase activity
RN05_RS07290	COG2801	Transposase and inactivated derivatives
RN05_RS07295	COG2963	transposase activity
RN05_RS07330	COG2226	methyltransferase
RN05_RS07410	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
RN05_RS07415	COG2072	flavoprotein involved in K transport
RN05_RS07420	COG2124	cytochrome p450
RN05_RS07450	COG0657	acetylesterase activity
RN05_RS07565	COG1481	regulation of sporulation
RN05_RS07580	COG0657	acetylesterase activity
RN05_RS07585	COG0318	PFAM AMP-dependent synthetase and ligase
RN05_RS07600	COG5651	PPE family
RN05_RS07600	COG3391	amine dehydrogenase activity
RN05_RS07615	COG1376	ErfK ybiS ycfS ynhG family protein
RN05_RS07640	COG0149	triose-phosphate isomerase activity
RN05_RS07660	COG0657	acetylesterase activity
RN05_RS07700	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
RN05_RS07705	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
RN05_RS07755	COG1131	(ABC) transporter
RN05_RS07775	COG0719	Fe-S assembly protein
RN05_RS07780	COG0396	ATPase activity
RN05_RS07795	COG2151	metal-sulfur cluster biosynthetic enzyme
RN05_RS07800	COG1960	acyl-CoA dehydrogenase activity
RN05_RS07820	COG3118	belongs to the thioredoxin family
RN05_RS07830	COG0488	(ABC) transporter
RN05_RS07840	COG1309	transcriptional regulator
RN05_RS07845	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
RN05_RS07855	COG3883	PFAM NLP P60 protein
RN05_RS07855	COG0791	NLP P60 protein
RN05_RS07865	COG0714	Associated with various cellular activities
RN05_RS07875	COG2304	oxidoreductase activity
RN05_RS07960	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
RN05_RS07965	COG2226	methyltransferase
RN05_RS07970	COG3360	Dodecin
RN05_RS07990	COG1621	beta-fructofuranosidase activity
RN05_RS08000	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
RN05_RS08010	COG4106	trans-aconitate 2-methyltransferase activity
RN05_RS08030	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
RN05_RS08045	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
RN05_RS08050	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RN05_RS08125	COG0604	alcohol dehydrogenase
RN05_RS08125	COG3321	synthase
RN05_RS08125	COG1028	Short-chain dehydrogenase reductase Sdr
RN05_RS08155	COG2070	2-Nitropropane dioxygenase
RN05_RS08210	COG0300	oxidoreductase activity
RN05_RS08260	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
RN05_RS08320	COG3883	PFAM NLP P60 protein
RN05_RS08320	COG0791	NLP P60 protein
RN05_RS08340	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
RN05_RS08440	COG1073	alpha beta
RN05_RS08490	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
RN05_RS08500	COG0483	inositol monophosphate 1-phosphatase activity
RN05_RS08505	COG0107	imidazoleglycerol-phosphate synthase activity
RN05_RS08515	COG0387	Pfam Sodium calcium exchanger
RN05_RS08570	COG1946	Acyl-CoA thioesterase
RN05_RS08575	COG0456	acetyltransferase
RN05_RS08575	COG0454	-acetyltransferase
RN05_RS08580	COG1132	(ABC) transporter
RN05_RS08585	COG4988	ABC transporter
RN05_RS08590	COG1294	oxidase, subunit
RN05_RS08595	COG1271	oxidase subunit
RN05_RS08670	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RN05_RS08690	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
RN05_RS08690	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
RN05_RS08720	COG0657	acetylesterase activity
RN05_RS08735	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
RN05_RS08745	COG3391	amine dehydrogenase activity
RN05_RS08800	COG0604	alcohol dehydrogenase
RN05_RS08800	COG3321	synthase
RN05_RS08805	COG3321	synthase
RN05_RS08805	COG4221	oxidoreductase activity
RN05_RS08805	COG0604	alcohol dehydrogenase
RN05_RS08805	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
RN05_RS08810	COG3321	synthase
RN05_RS08810	COG0604	alcohol dehydrogenase
RN05_RS08810	COG0604	alcohol dehydrogenase
RN05_RS08810	COG3321	synthase
RN05_RS08880	COG1960	acyl-CoA dehydrogenase activity
RN05_RS08885	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
RN05_RS08905	COG2835	tetraacyldisaccharide 4'-kinase activity
RN05_RS08945	COG0647	UMP catabolic process
RN05_RS08985	COG0494	nUDIX hydrolase
RN05_RS09000	COG4122	O-methyltransferase activity
RN05_RS09005	COG1113	amino acid transport
RN05_RS09010	COG5651	PPE family
RN05_RS09025	COG0659	secondary active sulfate transmembrane transporter activity
RN05_RS09035	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
RN05_RS09040	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
RN05_RS09080	COG3246	L-lysine catabolic process to acetate
RN05_RS09200	COG0659	secondary active sulfate transmembrane transporter activity
RN05_RS09230	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
RN05_RS09240	COG0842	Transport permease protein
RN05_RS09240	COG1131	(ABC) transporter
RN05_RS09240	COG1716	ATPase activity
RN05_RS09255	COG0318	PFAM AMP-dependent synthetase and ligase
RN05_RS09270	COG5263	repeat protein
RN05_RS09270	COG5651	PPE family
RN05_RS09285	COG2801	Transposase and inactivated derivatives
RN05_RS09290	COG2963	transposase activity
RN05_RS09300	COG0438	transferase activity, transferring glycosyl groups
RN05_RS09320	COG2801	Transposase and inactivated derivatives
RN05_RS09325	COG2963	transposase activity
RN05_RS09335	COG5651	PPE family
RN05_RS09340	COG2963	transposase activity
RN05_RS09345	COG2801	Transposase and inactivated derivatives
RN05_RS09350	COG2963	transposase activity
RN05_RS09355	COG2801	Transposase and inactivated derivatives
RN05_RS09360	COG2801	Transposase and inactivated derivatives
RN05_RS09375	COG1937	Protein conserved in bacteria
RN05_RS09475	COG5651	PPE family
RN05_RS09485	COG5651	PPE family
RN05_RS09490	COG5651	PPE family
RN05_RS09520	COG1404	Belongs to the peptidase S8 family
RN05_RS09540	COG5651	PPE family
RN05_RS09570	COG0657	acetylesterase activity
RN05_RS09585	COG5651	PPE family
RN05_RS09595	COG1285	pathogenesis
RN05_RS09600	COG1252	NADH dehydrogenase
RN05_RS09670	COG0509	glycine decarboxylation via glycine cleavage system
RN05_RS09695	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
RN05_RS09695	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
RN05_RS09740	COG1253	flavin adenine dinucleotide binding
RN05_RS09745	COG1253	flavin adenine dinucleotide binding
RN05_RS09755	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
RN05_RS09790	COG0830	nickel cation binding
RN05_RS09810	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RN05_RS09860	COG4221	oxidoreductase activity
RN05_RS09865	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RN05_RS09870	COG0183	Belongs to the thiolase family
RN05_RS09925	COG0174	glutamine synthetase
RN05_RS09945	COG0300	oxidoreductase activity
RN05_RS09965	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
RN05_RS10005	COG2070	2-Nitropropane dioxygenase
RN05_RS10010	COG1063	alcohol dehydrogenase
RN05_RS10020	COG1490	D-aminoacyl-tRNA deacylase activity
RN05_RS10050	COG1950	PFAM Membrane protein of
RN05_RS10055	COG1366	Belongs to the anti-sigma-factor antagonist family
RN05_RS10075	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
RN05_RS10110	COG2224	Isocitrate lyase
RN05_RS10120	COG5263	repeat protein
RN05_RS10120	COG5651	PPE family
RN05_RS10125	COG5651	PPE family
RN05_RS10125	COG5263	repeat protein
RN05_RS10145	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
RN05_RS10150	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
RN05_RS10160	COG0318	PFAM AMP-dependent synthetase and ligase
RN05_RS10175	COG1028	Short-chain dehydrogenase reductase Sdr
RN05_RS10190	COG4977	sequence-specific DNA binding
RN05_RS10200	COG1960	acyl-CoA dehydrogenase activity
RN05_RS10210	COG1024	Enoyl-CoA hydratase
RN05_RS10220	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
RN05_RS10220	COG0543	2 iron, 2 sulfur cluster binding
RN05_RS10225	COG0596	Alpha beta hydrolase
RN05_RS10235	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
RN05_RS10235	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
RN05_RS10240	COG1028	Short-chain dehydrogenase reductase Sdr
RN05_RS10245	COG2337	Toxic component of a toxin-antitoxin (TA) module
RN05_RS10255	COG0653	protein targeting
RN05_RS10300	COG4691	Plasmid stability protein
RN05_RS10360	COG1309	transcriptional regulator
RN05_RS10400	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
RN05_RS10480	COG1872	DUF167
RN05_RS10520	COG1028	Short-chain dehydrogenase reductase Sdr
RN05_RS10665	COG2442	InterPro IPR007367
RN05_RS10680	COG1396	sequence-specific DNA binding
RN05_RS10685	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
RN05_RS10750	COG0640	Transcriptional regulator
RN05_RS10765	COG1752	Esterase of the alpha-beta hydrolase superfamily
RN05_RS10770	COG3842	ATPase activity
RN05_RS10775	COG0395	ABC-type sugar transport system, permease component
RN05_RS10780	COG1175	transmembrane transport
RN05_RS10795	COG1335	isochorismatase
RN05_RS10820	COG0604	alcohol dehydrogenase
RN05_RS10820	COG3321	synthase
RN05_RS10880	COG0803	Belongs to the bacterial solute-binding protein 9 family
RN05_RS10905	COG2337	Toxic component of a toxin-antitoxin (TA) module
RN05_RS10930	COG2367	Beta-lactamase
RN05_RS10950	COG2242	protein methyltransferase activity
RN05_RS10950	COG2241	protein methyltransferase activity
RN05_RS10955	COG0300	oxidoreductase activity
RN05_RS10990	COG1511	domain protein
RN05_RS11040	COG2801	Transposase and inactivated derivatives
RN05_RS11060	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
RN05_RS11110	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
RN05_RS11115	COG4279	zinc finger
RN05_RS11120	COG1848	Toxic component of a toxin-antitoxin (TA) module. An RNase
RN05_RS11130	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
RN05_RS11135	COG2963	transposase activity
RN05_RS11140	COG2801	Transposase and inactivated derivatives
RN05_RS11155	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
RN05_RS11225	COG5651	PPE family
RN05_RS11230	COG0646	methionine synthase
RN05_RS11230	COG1410	methionine synthase
RN05_RS11260	COG1028	Short-chain dehydrogenase reductase Sdr
RN05_RS11315	COG0167	dihydroorotate dehydrogenase activity
RN05_RS11325	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RN05_RS11380	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
RN05_RS11395	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
RN05_RS11405	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
RN05_RS11450	COG0768	penicillin binding
RN05_RS11470	COG2801	Transposase and inactivated derivatives
RN05_RS11475	COG2963	transposase activity
RN05_RS11500	COG0142	geranyltranstransferase activity
RN05_RS11525	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
RN05_RS11555	COG0003	Pfam Anion-transporting ATPase
RN05_RS11570	COG1022	Amp-dependent synthetase and ligase
RN05_RS11655	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RN05_RS11685	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
RN05_RS11710	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
RN05_RS11730	COG0321	lipoyl(octanoyl) transferase activity
RN05_RS11785	COG5607	PFAM CHAD domain containing protein
RN05_RS11785	COG3025	triphosphatase activity
RN05_RS11820	COG3744	PilT protein domain protein
RN05_RS11845	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
RN05_RS11990	COG4221	oxidoreductase activity
RN05_RS12060	COG0584	glycerophosphoryl diester phosphodiesterase
RN05_RS12065	COG2963	transposase activity
RN05_RS12070	COG2801	Transposase and inactivated derivatives
RN05_RS12095	COG0657	acetylesterase activity
RN05_RS12210	COG1073	alpha beta
RN05_RS12230	COG2442	InterPro IPR007367
RN05_RS12290	COG0395	ABC-type sugar transport system, permease component
RN05_RS12305	COG0531	amino acid
RN05_RS12310	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
RN05_RS12315	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
RN05_RS12320	COG1834	amidinotransferase
RN05_RS12325	COG1522	sequence-specific DNA binding
RN05_RS12355	COG2223	nitrite transmembrane transporter activity
RN05_RS12380	COG0477	Major facilitator Superfamily
RN05_RS12390	COG1045	serine acetyltransferase
RN05_RS12405	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
RN05_RS12505	COG2963	transposase activity
RN05_RS12510	COG2801	Transposase and inactivated derivatives
RN05_RS12585	COG0657	acetylesterase activity
RN05_RS12600	COG1420	regulation of RNA biosynthetic process
RN05_RS12615	COG3251	PFAM MbtH domain protein
RN05_RS12630	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
RN05_RS12645	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
RN05_RS12645	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
RN05_RS12650	COG1021	2,3-dihydroxybenzoate-AMP ligase
RN05_RS12710	COG1297	OPT oligopeptide transporter protein
RN05_RS12735	COG4208	sulfate ABC transporter
RN05_RS12745	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
RN05_RS12760	COG3387	PFAM Glycoside hydrolase 15-related
RN05_RS12785	COG1234	tRNA 3'-trailer cleavage
RN05_RS12795	COG1305	Transglutaminase-like
RN05_RS12825	COG1596	polysaccharide export
RN05_RS12825	COG1555	photosystem II stabilization
RN05_RS12840	COG2755	lipolytic protein G-D-S-L family
RN05_RS12850	COG0799	negative regulation of ribosome biogenesis
RN05_RS12855	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
RN05_RS12890	COG0542	response to heat
RN05_RS12920	COG5651	PPE family
RN05_RS12940	COG0668	transmembrane transport
RN05_RS12945	COG5002	protein histidine kinase activity
RN05_RS12950	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RN05_RS12965	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
RN05_RS12985	COG1301	dicarboxylic acid transport
RN05_RS12990	COG1530	ribonuclease E activity
RN05_RS13005	COG0285	dihydrofolate synthase activity
RN05_RS13015	COG3268	Saccharopine dehydrogenase
RN05_RS13020	COG1388	LysM domain
RN05_RS13040	COG1013	pyruvate-flavodoxin oxidoreductase activity
RN05_RS13045	COG0674	pyruvate-flavodoxin oxidoreductase activity
RN05_RS13045	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
RN05_RS13055	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
RN05_RS13060	COG2040	homocysteine
RN05_RS13080	COG0544	peptidyl-prolyl cis-trans isomerase activity
RN05_RS13095	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
RN05_RS13110	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
RN05_RS13140	COG0366	Alpha amylase catalytic
RN05_RS13160	COG0824	Thioesterase
RN05_RS13165	COG2902	Dehydrogenase
RN05_RS13180	COG2801	Transposase and inactivated derivatives
RN05_RS13185	COG2963	transposase activity
RN05_RS13195	COG2937	Belongs to the GPAT DAPAT family
RN05_RS13210	COG0657	acetylesterase activity
RN05_RS13225	COG0657	acetylesterase activity
RN05_RS13265	COG1848	Toxic component of a toxin-antitoxin (TA) module. An RNase
RN05_RS13270	COG0508	dehydrogenase complex catalyzes the overall conversion of
RN05_RS13290	COG2030	dehydratase
RN05_RS13295	COG1960	acyl-CoA dehydrogenase activity
RN05_RS13305	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
RN05_RS13320	COG0318	PFAM AMP-dependent synthetase and ligase
RN05_RS13340	COG0300	oxidoreductase activity
RN05_RS13345	COG0433	COG0433 Predicted ATPase
RN05_RS13360	COG3328	transposase activity
RN05_RS13400	COG1376	ErfK ybiS ycfS ynhG family protein
RN05_RS13440	COG3757	hydrolase, family 25
RN05_RS13455	COG1715	Restriction endonuclease
RN05_RS13485	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
RN05_RS13550	COG1487	ribonuclease activity
RN05_RS13590	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
RN05_RS13600	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
RN05_RS13605	COG0432	Pfam Uncharacterised protein family UPF0047
RN05_RS13625	COG5473	translation initiation factor activity
RN05_RS13665	COG2308	Evidence 4 Homologs of previously reported genes of
RN05_RS13665	COG2307	Protein conserved in bacteria
RN05_RS13725	COG0596	Alpha beta hydrolase
RN05_RS13750	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
RN05_RS13755	COG0747	negative chemotaxis
RN05_RS13760	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
RN05_RS13780	COG1022	Amp-dependent synthetase and ligase
RN05_RS13780	COG3320	Male sterility
RN05_RS13860	COG1946	Acyl-CoA thioesterase
RN05_RS13875	COG5651	PPE family
RN05_RS13890	COG1560	Kdo2-lipid A biosynthetic process
RN05_RS13915	COG3391	amine dehydrogenase activity
RN05_RS13920	COG4762	Protein conserved in bacteria
RN05_RS14035	COG1366	Belongs to the anti-sigma-factor antagonist family
RN05_RS14055	COG0640	Transcriptional regulator
RN05_RS14060	COG0798	PFAM Bile acid sodium symporter
RN05_RS14095	COG4974	Belongs to the 'phage' integrase family
RN05_RS14105	COG2963	transposase activity
RN05_RS14110	COG2801	Transposase and inactivated derivatives
RN05_RS14190	COG3328	transposase activity
RN05_RS14230	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
RN05_RS14300	COG1131	(ABC) transporter
RN05_RS14310	COG0531	amino acid
RN05_RS14315	COG0569	domain protein
RN05_RS14370	COG1940	carbohydrate kinase activity
RN05_RS14455	COG1388	LysM domain
RN05_RS14460	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
RN05_RS14480	COG1960	acyl-CoA dehydrogenase activity
RN05_RS14485	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
RN05_RS14515	COG1196	nuclear chromosome segregation
RN05_RS14560	COG4308	Limonene-1,2-epoxide hydrolase catalytic domain
RN05_RS14565	COG3391	amine dehydrogenase activity
RN05_RS14585	COG1842	Phage shock protein A
RN05_RS14600	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
RN05_RS14645	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
RN05_RS14695	COG1028	Short-chain dehydrogenase reductase Sdr
RN05_RS14730	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
RN05_RS14760	COG1522	sequence-specific DNA binding
RN05_RS14765	COG0686	Belongs to the AlaDH PNT family
RN05_RS14810	COG1960	acyl-CoA dehydrogenase activity
RN05_RS14815	COG0183	Belongs to the thiolase family
RN05_RS14835	COG2977	Belongs to the P-Pant transferase superfamily
RN05_RS14840	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
RN05_RS14870	COG2337	Toxic component of a toxin-antitoxin (TA) module
RN05_RS14875	COG3609	addiction module antidote protein, CC2985 family
RN05_RS14940	COG2801	Transposase and inactivated derivatives
RN05_RS14945	COG2963	transposase activity
RN05_RS14985	COG1353	crispr-associated protein
RN05_RS15020	COG3744	PilT protein domain protein
RN05_RS15025	COG4118	positive regulation of growth
RN05_RS15035	COG3842	ATPase activity
RN05_RS15040	COG1653	transport
RN05_RS15045	COG0395	ABC-type sugar transport system, permease component
RN05_RS15060	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
RN05_RS15110	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
RN05_RS15110	COG1648	precorrin-2 dehydrogenase activity
RN05_RS15155	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
RN05_RS15180	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
RN05_RS15215	COG2161	toxin-antitoxin pair type II binding
RN05_RS15220	COG2026	Addiction module toxin, RelE StbE family
RN05_RS15265	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
RN05_RS15265	COG0785	Cytochrome C biogenesis protein
RN05_RS15305	COG0233	cytoplasmic translational termination
RN05_RS15315	COG0745	RESPONSE REGULATOR receiver
RN05_RS15340	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
RN05_RS15445	COG1686	Belongs to the peptidase S11 family
RN05_RS15475	COG1061	Type III restriction enzyme res subunit
RN05_RS15480	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
RN05_RS15550	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
RN05_RS15550	COG3321	synthase
RN05_RS15630	COG3321	synthase
RN05_RS15645	COG0318	PFAM AMP-dependent synthetase and ligase
RN05_RS15690	COG1819	glycosyl
RN05_RS15715	COG0701	Predicted permease
RN05_RS15735	COG0742	ribosomal rna small subunit methyltransferase
RN05_RS15740	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
RN05_RS15755	COG0657	acetylesterase activity
RN05_RS15760	COG0656	L-ascorbic acid biosynthetic process
RN05_RS15765	COG0656	L-ascorbic acid biosynthetic process
RN05_RS15780	COG1461	Dihydroxyacetone kinase
RN05_RS15820	COG1181	Belongs to the D-alanine--D-alanine ligase family
RN05_RS15825	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
RN05_RS15855	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
RN05_RS15885	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
RN05_RS15890	COG0179	Fumarylacetoacetate (FAA) hydrolase
RN05_RS15895	COG2271	Major facilitator Superfamily
RN05_RS15920	COG2972	Histidine kinase
RN05_RS15930	COG0390	transport system, permease component
RN05_RS15955	COG2259	Doxx family
RN05_RS15985	COG0154	amidase activity
RN05_RS16045	COG3328	transposase activity
RN05_RS16105	COG0110	maltose O-acetyltransferase activity
RN05_RS16110	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
RN05_RS16140	COG1119	ATPase activity
RN05_RS16145	COG3830	Belongs to the UPF0237 family
RN05_RS16145	COG0560	Phosphoserine phosphatase
RN05_RS16190	COG1309	transcriptional regulator
RN05_RS16240	COG2186	Transcriptional regulator
RN05_RS16245	COG1960	acyl-CoA dehydrogenase activity
RN05_RS16250	COG1793	dna ligase
RN05_RS16255	COG1966	Carbon starvation protein
RN05_RS16340	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RN05_RS16405	COG2354	Protein conserved in bacteria
RN05_RS16430	COG0657	acetylesterase activity
RN05_RS16440	COG2337	Toxic component of a toxin-antitoxin (TA) module
RN05_RS16460	COG2177	Part of the ABC transporter FtsEX involved in
RN05_RS16465	COG2884	Cell division ATP-binding protein ftsE
RN05_RS16475	COG0668	transmembrane transport
RN05_RS16490	COG0277	FAD linked oxidase domain protein
RN05_RS16510	COG2154	pterin-4-alpha-carbinolamine dehydratase
RN05_RS16520	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
RN05_RS16535	COG3328	transposase activity
RN05_RS16565	COG2124	cytochrome p450
RN05_RS16580	COG3629	intracellular signal transduction
RN05_RS16605	COG2801	Transposase and inactivated derivatives
RN05_RS16640	COG5651	PPE family
RN05_RS16655	COG0483	inositol monophosphate 1-phosphatase activity
RN05_RS16670	COG1960	acyl-CoA dehydrogenase activity
RN05_RS16675	COG3321	synthase
RN05_RS16675	COG0604	alcohol dehydrogenase
RN05_RS16675	COG4221	oxidoreductase activity
RN05_RS16675	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
RN05_RS16725	COG1034	ATP synthesis coupled electron transport
RN05_RS16735	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RN05_RS16790	COG0714	Associated with various cellular activities
RN05_RS16835	COG1309	transcriptional regulator
RN05_RS16845	COG0154	amidase activity
RN05_RS16860	COG0748	coenzyme F420 binding
RN05_RS16885	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
RN05_RS16890	COG1396	sequence-specific DNA binding
RN05_RS16895	COG2963	transposase activity
RN05_RS16900	COG2801	Transposase and inactivated derivatives
RN05_RS16930	COG2826	transposase and inactivated derivatives, IS30 family
RN05_RS16950	COG1615	UPF0182 protein
RN05_RS16975	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
RN05_RS16995	COG2816	NAD+ diphosphatase activity
RN05_RS17005	COG0210	DNA helicase
RN05_RS17020	COG0596	Alpha beta hydrolase
RN05_RS17025	COG3695	enzyme binding
RN05_RS17065	COG0513	Belongs to the DEAD box helicase family
RN05_RS17080	COG0406	alpha-ribazole phosphatase activity
RN05_RS17100	COG1597	lipid kinase activity
RN05_RS17135	COG1028	Short-chain dehydrogenase reductase Sdr
RN05_RS17145	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
RN05_RS17155	COG2135	peptidase activity
RN05_RS17160	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
RN05_RS17165	COG1162	GTPase activity
RN05_RS17185	COG2326	polyphosphate kinase activity
RN05_RS17200	COG4651	solute:proton antiporter activity
RN05_RS17200	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
RN05_RS17210	COG2020	methyltransferase activity
RN05_RS17225	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
RN05_RS17245	COG5002	protein histidine kinase activity
RN05_RS17245	COG5000	phosphorelay sensor kinase activity
RN05_RS17280	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RN05_RS17285	COG0531	amino acid
RN05_RS17290	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RN05_RS17295	COG1482	cell wall glycoprotein biosynthetic process
RN05_RS17305	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
RN05_RS17355	COG1316	TRANSCRIPTIONal
RN05_RS17380	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RN05_RS17385	COG0659	secondary active sulfate transmembrane transporter activity
RN05_RS17420	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
RN05_RS17430	COG0424	maF-like protein
RN05_RS17445	COG4770	biotin carboxylase activity
RN05_RS17475	COG1522	sequence-specific DNA binding
RN05_RS17485	COG1012	belongs to the aldehyde dehydrogenase family
RN05_RS17495	COG1309	transcriptional regulator
RN05_RS17500	COG1201	RNA secondary structure unwinding
RN05_RS17515	COG3119	arylsulfatase activity
RN05_RS17515	COG3408	Glycogen debranching enzyme
RN05_RS17520	COG0564	pseudouridine synthase activity
RN05_RS17545	COG1473	amidohydrolase
RN05_RS17545	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
RN05_RS17560	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
RN05_RS17570	COG3511	phospholipase C
RN05_RS17605	COG2009	succinate dehydrogenase
RN05_RS17615	COG1053	succinate dehydrogenase
RN05_RS17620	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
RN05_RS17655	COG2963	transposase activity
RN05_RS17660	COG2801	Transposase and inactivated derivatives
RN05_RS17665	COG3547	Transposase (IS116 IS110 IS902 family)
RN05_RS17670	COG1595	DNA-templated transcription, initiation
RN05_RS17675	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
RN05_RS17680	COG1686	Belongs to the peptidase S11 family
RN05_RS17685	COG2814	Major facilitator Superfamily
RN05_RS17690	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
RN05_RS17700	COG0789	Transcriptional regulator
RN05_RS17725	COG2873	o-acetylhomoserine
RN05_RS17740	COG5651	PPE family
RN05_RS17760	COG5651	PPE family
RN05_RS17760	COG5651	PPE family
RN05_RS17780	COG5651	PPE family
RN05_RS17780	COG5651	PPE family
RN05_RS17780	COG5651	PPE family
RN05_RS17790	COG0277	FAD linked oxidase domain protein
RN05_RS17810	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
RN05_RS17830	COG0842	Transport permease protein
RN05_RS17830	COG1131	(ABC) transporter
RN05_RS17830	COG1716	ATPase activity
RN05_RS17835	COG1357	PFAM Pentapeptide repeats (8 copies)
RN05_RS17850	COG2018	Roadblock/LC7 domain
RN05_RS17860	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
RN05_RS17885	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
RN05_RS17895	COG1024	Enoyl-CoA hydratase
RN05_RS17915	COG1657	PFAM Prenyltransferase squalene oxidase
RN05_RS17925	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
RN05_RS17935	COG2801	Transposase and inactivated derivatives
RN05_RS17940	COG2963	transposase activity
RN05_RS17950	COG0142	geranyltranstransferase activity
RN05_RS17955	COG1848	Toxic component of a toxin-antitoxin (TA) module. An RNase
RN05_RS17990	COG2030	dehydratase
RN05_RS17995	COG0406	alpha-ribazole phosphatase activity
RN05_RS18005	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
RN05_RS18045	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
RN05_RS18090	COG1848	Toxic component of a toxin-antitoxin (TA) module. An RNase
RN05_RS18150	COG0456	acetyltransferase
RN05_RS18175	COG5651	PPE family
RN05_RS18180	COG5651	PPE family
RN05_RS18185	COG1484	DNA-dependent DNA replication
RN05_RS18190	COG4584	PFAM Integrase catalytic
RN05_RS18205	COG2801	Transposase and inactivated derivatives
RN05_RS18210	COG3328	transposase activity
RN05_RS18215	COG0076	glutamate decarboxylase activity
RN05_RS18275	COG4842	Belongs to the WXG100 family
RN05_RS18280	COG4842	Belongs to the WXG100 family
RN05_RS18290	COG1674	ftsk spoiiie
RN05_RS18300	COG1404	Belongs to the peptidase S8 family
RN05_RS18350	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
RN05_RS18365	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
RN05_RS18390	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
RN05_RS18395	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
RN05_RS18400	COG0028	Belongs to the TPP enzyme family
RN05_RS18420	COG2963	transposase activity
RN05_RS18425	COG2801	Transposase and inactivated derivatives
RN05_RS18430	COG0477	Major facilitator Superfamily
RN05_RS18445	COG1752	Esterase of the alpha-beta hydrolase superfamily
RN05_RS18450	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
RN05_RS18470	COG1316	TRANSCRIPTIONal
RN05_RS18475	COG1028	Short-chain dehydrogenase reductase Sdr
RN05_RS18480	COG2259	Doxx family
RN05_RS18485	COG0657	acetylesterase activity
RN05_RS18490	COG1695	Transcriptional regulator
RN05_RS18500	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
RN05_RS18525	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
RN05_RS18550	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
RN05_RS18555	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
RN05_RS18570	COG1960	acyl-CoA dehydrogenase activity
RN05_RS18575	COG1960	acyl-CoA dehydrogenase activity
RN05_RS18580	COG0318	PFAM AMP-dependent synthetase and ligase
RN05_RS18595	COG0028	Belongs to the TPP enzyme family
RN05_RS18635	COG1024	Enoyl-CoA hydratase
RN05_RS18645	COG2124	cytochrome p450
RN05_RS18655	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RN05_RS18665	COG0183	Belongs to the thiolase family
RN05_RS18670	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
RN05_RS18685	COG4638	Rieske (2fe-2S)
RN05_RS18710	COG1028	Short-chain dehydrogenase reductase Sdr
RN05_RS18740	COG3971	2-oxopent-4-enoate hydratase activity
RN05_RS18745	COG1053	succinate dehydrogenase
RN05_RS18750	COG2030	dehydratase
RN05_RS18770	COG2030	dehydratase
RN05_RS18775	COG1960	acyl-CoA dehydrogenase activity
RN05_RS18780	COG1960	acyl-CoA dehydrogenase activity
RN05_RS18790	COG0183	Belongs to the thiolase family
RN05_RS18800	COG1028	Short-chain dehydrogenase reductase Sdr
RN05_RS18810	COG1024	Enoyl-CoA hydratase
RN05_RS18830	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
RN05_RS18840	COG0183	Belongs to the thiolase family
RN05_RS18860	COG1960	acyl-CoA dehydrogenase activity
RN05_RS18865	COG0318	PFAM AMP-dependent synthetase and ligase
RN05_RS18870	COG1960	acyl-CoA dehydrogenase activity
RN05_RS18875	COG1960	acyl-CoA dehydrogenase activity
RN05_RS18880	COG1960	acyl-CoA dehydrogenase activity
RN05_RS18885	COG0436	Aminotransferase
RN05_RS18930	COG1960	acyl-CoA dehydrogenase activity
RN05_RS18935	COG1309	transcriptional regulator
RN05_RS18940	COG1609	Transcriptional regulator
RN05_RS18960	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RN05_RS18995	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
RN05_RS19015	COG0657	acetylesterase activity
RN05_RS19035	COG0739	heme binding
RN05_RS19115	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
RN05_RS19150	COG2267	carboxylic ester hydrolase activity
RN05_RS19200	COG2027	D-alanyl-D-alanine carboxypeptidase
RN05_RS19215	COG2244	polysaccharide biosynthetic process
RN05_RS19265	COG3328	transposase activity
RN05_RS19270	COG2184	nucleotidyltransferase activity
RN05_RS19290	COG0470	DNA polymerase III
RN05_RS19315	COG1111	helicase
RN05_RS19315	COG1205	dead DEAH box helicase
RN05_RS19320	COG0657	acetylesterase activity
RN05_RS19330	COG3391	amine dehydrogenase activity
RN05_RS19385	COG4172	Belongs to the ABC transporter superfamily
RN05_RS19390	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RN05_RS19395	COG0601	transmembrane transport
RN05_RS19430	COG0494	nUDIX hydrolase
RN05_RS19455	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RN05_RS19490	COG1408	metallophosphoesterase
RN05_RS19495	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
RN05_RS19540	COG0714	Associated with various cellular activities
RN05_RS19560	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
RN05_RS19595	COG0121	glutamine amidotransferase
RN05_RS19600	COG1262	PFAM Formylglycine-generating sulfatase enzyme
RN05_RS19650	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
RN05_RS19675	COG0860	N-Acetylmuramoyl-L-alanine amidase
RN05_RS19690	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
RN05_RS19700	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RN05_RS19730	COG1063	alcohol dehydrogenase
RN05_RS19735	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RN05_RS19735	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
RN05_RS19740	COG0477	Major facilitator Superfamily
RN05_RS19745	COG2226	methyltransferase
RN05_RS19755	COG1793	dna ligase
RN05_RS19810	COG2072	flavoprotein involved in K transport
RN05_RS19820	COG0640	Transcriptional regulator
RN05_RS19845	COG1569	PIN domain
RN05_RS19850	COG3311	Transcriptional regulator
RN05_RS19865	COG0590	tRNA wobble adenosine to inosine editing
RN05_RS19875	COG0287	Prephenate dehydrogenase
RN05_RS19895	COG0517	IMP dehydrogenase activity
RN05_RS19895	COG1125	glycine betaine transport
RN05_RS19905	COG5416	Lipopolysaccharide assembly protein A domain
RN05_RS19915	COG2015	COG2015, Alkyl sulfatase and related hydrolases
RN05_RS19925	COG2205	protein histidine kinase activity
RN05_RS19930	COG0745	RESPONSE REGULATOR receiver
RN05_RS19935	COG0739	heme binding
RN05_RS19985	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
RN05_RS20005	COG1403	HNH endonuclease
RN05_RS20050	COG1088	dTDP-glucose 4,6-dehydratase activity
RN05_RS20095	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
RN05_RS20110	COG1234	tRNA 3'-trailer cleavage
RN05_RS20115	COG1960	acyl-CoA dehydrogenase activity
RN05_RS20125	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
RN05_RS20130	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
RN05_RS20130	COG3321	synthase
RN05_RS20130	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
RN05_RS20135	COG0318	PFAM AMP-dependent synthetase and ligase
RN05_RS20140	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
RN05_RS20155	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
RN05_RS20170	COG1216	Glycosyl transferase, family 2
RN05_RS20190	COG0657	acetylesterase activity
RN05_RS20200	COG0561	phosphatase activity
RN05_RS20235	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
RN05_RS20245	COG5651	PPE family
RN05_RS20250	COG1511	domain protein
RN05_RS20250	COG2409	Drug exporters of the RND superfamily
RN05_RS20260	COG3321	synthase
RN05_RS20260	COG1028	Short-chain dehydrogenase reductase Sdr
RN05_RS20260	COG0604	alcohol dehydrogenase
RN05_RS20305	COG2207	Transcriptional regulator
RN05_RS20340	COG1316	TRANSCRIPTIONal
RN05_RS20385	COG2119	membrane
RN05_RS20425	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
RN05_RS20425	COG1796	DNA polymerase
RN05_RS20440	COG0067	glutamate synthase
RN05_RS20440	COG0069	glutamate synthase activity
RN05_RS20440	COG0070	glutamate synthase
RN05_RS20560	COG1404	Belongs to the peptidase S8 family
RN05_RS20565	COG0464	growth
RN05_RS20575	COG1404	Belongs to the peptidase S8 family
RN05_RS20605	COG5651	PPE family
RN05_RS20615	COG1674	ftsk spoiiie
RN05_RS20700	COG1595	DNA-templated transcription, initiation
RN05_RS20720	COG3409	Peptidoglycan-binding domain 1 protein
RN05_RS20720	COG0860	N-Acetylmuramoyl-L-alanine amidase
RN05_RS20735	COG1192	Involved in chromosome partitioning
RN05_RS20755	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
RN05_RS20765	COG0230	Belongs to the bacterial ribosomal protein bL34 family