locus-tag class description FOC65_RS00010 ENOG4105C4R Atp-dependent dna helicase FOC65_RS00025 ENOG4108YIQ Alpha beta hydrolase FOC65_RS00030 ENOG41080UX Methyltransferase FOC65_RS00070 ENOG4105C1J atp-dependent rna helicase FOC65_RS00085 ENOG4108ZM9 phosphoglycerate mutase FOC65_RS00105 ENOG4105CBD Diacylglycerol kinase FOC65_RS00140 ENOG4105CHR reductase FOC65_RS00145 ENOG4108Z66 YbaK ebsC protein FOC65_RS00155 ENOG4108RAV Conserved protein FOC65_RS00160 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase FOC65_RS00165 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) FOC65_RS00185 ENOG4105CSR polyphosphate kinase 2 FOC65_RS00205 ENOG4105CKD glutathione-regulated potassium-efflux system protein FOC65_RS00215 ENOG4108SVW integral membrane protein FOC65_RS00230 ENOG4108S7Q sigma 54 modulation protein ribosomal protein S30ea FOC65_RS00250 ENOG4105BZU Histidine kinase FOC65_RS00275 ENOG4105VCQ rubredoxin FOC65_RS00280 ENOG41084UD rubredoxin FOC65_RS00285 ENOG4105EEF Alkane 1-monooxygenase FOC65_RS00290 ENOG4105CUB amino acid FOC65_RS00300 ENOG4105EIP mannose-6-phosphate isomerase FOC65_RS00310 ENOG4107QKV phosphomannomutase FOC65_RS00325 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) FOC65_RS00360 ENOG4107TB5 TRANSCRIPTIONal FOC65_RS00385 ENOG410846T CoA-transferase family III FOC65_RS00390 ENOG4105CHH sulfate transporter FOC65_RS00425 ENOG4105D8K carboxyl transferase FOC65_RS00450 ENOG4108JIK carboxylase FOC65_RS00490 ENOG4105C26 Dehydrogenase FOC65_RS00505 ENOG4107QRT dEAD DEAH box helicase FOC65_RS00525 ENOG4105D3G Pseudouridine synthase FOC65_RS00550 ENOG4107RM1 amidohydrolase FOC65_RS00565 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain FOC65_RS00575 ENOG4105FBN Acid phosphatase FOC65_RS00630 ENOG4105E33 succinate dehydrogenase FOC65_RS00670 ENOG4107SVN transposase FOC65_RS00675 ENOG4108KPJ rna polymerase sigma factor FOC65_RS00680 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOC65_RS00685 ENOG4105DZ1 carboxypeptidase FOC65_RS00690 ENOG4105C54 Major Facilitator superfamily FOC65_RS00695 ENOG4105CE4 GlcNAc 6-P deacetylase FOC65_RS00705 ENOG4108Z6Z Transcriptional regulator FOC65_RS00710 ENOG4107H3J ribonuclease FOC65_RS00730 ENOG4108IQK o-acetylhomoserine FOC65_RS00795 ENOG4105DNP FAD linked oxidase domain protein FOC65_RS00820 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) FOC65_RS00835 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FOC65_RS00840 ENOG4105IDI abc transporter atp-binding protein FOC65_RS00845 ENOG4107Z6C Pentapeptide repeat-containing protein FOC65_RS00860 ENOG4105GWZ Roadblock lc7 family protein FOC65_RS00870 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) FOC65_RS00910 ENOG4105E39 Enoyl-CoA hydratase FOC65_RS00930 ENOG4107R2E Inherit from NOG: halimadienyl-diphosphate synthase activity FOC65_RS00940 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) FOC65_RS00945 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) FOC65_RS00965 ENOG4105YXB Toxic component of a toxin-antitoxin (TA) module. A FOC65_RS00990 ENOG4105GCF PGAM FOC65_RS01090 ENOG4105YXB Toxic component of a toxin-antitoxin (TA) module. A FOC65_RS01150 ENOG41080E2 ribosomal-protein-alanine acetyltransferase FOC65_RS01190 ENOG4105F5W AtP-binding protein FOC65_RS01195 ENOG4106IJN integrase catalytic domain-containing protein FOC65_RS01235 ENOG4105CVK Glutamate decarboxylase FOC65_RS01310 ENOG4105EC2 ftsk spoIIIe FOC65_RS01320 ENOG41090GG peptidase S8 and S53, subtilisin, kexin, sedolisin FOC65_RS01365 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) FOC65_RS01410 ENOG4105DF3 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity) FOC65_RS01415 ENOG4106WR0 acetolactate synthase (large subunit) FOC65_RS01440 ENOG4105CSH Transporter FOC65_RS01460 ENOG4105D8T Acyltransferase FOC65_RS01480 ENOG4107TB5 TRANSCRIPTIONal FOC65_RS01490 ENOG4105NQG DoxX FOC65_RS01500 ENOG4105VUN Transcriptional regulator FOC65_RS01510 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase FOC65_RS01570 ENOG4105CHR reductase FOC65_RS01580 ENOG4105X7H acyl-CoA dehydrogenase FOC65_RS01585 ENOG4108KC2 acyl-Coa dehydrogenase FOC65_RS01590 ENOG4105J5T Amp-dependent synthetase and ligase FOC65_RS01650 ENOG4105E39 Enoyl-CoA hydratase FOC65_RS01670 ENOG4105DYW oxidoreductase FOC65_RS01680 ENOG4105CHU acetyl-coa acetyltransferase FOC65_RS01685 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FOC65_RS01695 ENOG4108Z0R Transferase FOC65_RS01700 ENOG4105CIJ rieske 2fe-2S domain-containing protein FOC65_RS01725 ENOG4105CHR reductase FOC65_RS01755 ENOG4105IKQ hydratase FOC65_RS01760 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein FOC65_RS01785 ENOG410900P UPF0336 protein FOC65_RS01790 ENOG4105X7H acyl-CoA dehydrogenase FOC65_RS01795 ENOG4108RK3 acyl-Coa dehydrogenase FOC65_RS01805 ENOG4105F2C Acetyl-CoA acetyltransferase FOC65_RS01815 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr FOC65_RS01825 ENOG4105E39 Enoyl-CoA hydratase FOC65_RS01840 ENOG4105EA8 2-Nitropropane dioxygenase FOC65_RS01845 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) FOC65_RS01855 ENOG4105F2C Acetyl-CoA acetyltransferase FOC65_RS01875 ENOG4105CC9 acyl-Coa dehydrogenase FOC65_RS01880 ENOG4105CEY Amp-dependent synthetase and ligase FOC65_RS01885 ENOG4105CC9 acyl-Coa dehydrogenase FOC65_RS01890 ENOG4105D2B acyl-CoA dehydrogenase FOC65_RS01895 ENOG4105D2B acyl-CoA dehydrogenase FOC65_RS01900 ENOG4105CHM Aminotransferase FOC65_RS01950 ENOG4105D2B acyl-CoA dehydrogenase FOC65_RS01955 ENOG4108SGK Tetr family transcriptional regulator FOC65_RS01980 ENOG4105C2N RNA methyltransferase TrmH family group 3 FOC65_RS02130 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) FOC65_RS02160 ENOG4105D74 hydrolase FOC65_RS02225 ENOG4108XUD Membrane FOC65_RS02270 ENOG4105D5G Transposase FOC65_RS02275 ENOG4105MZU cell filamentation protein FOC65_RS02295 ENOG4107QRG dna polymerase iii FOC65_RS02320 ENOG4108I5C dEAD DEAH box helicase FOC65_RS02395 ENOG4108JQ6 ABC transporter FOC65_RS02400 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC65_RS02405 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOC65_RS02440 ENOG4105P8F nudix hydrolase FOC65_RS02465 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FOC65_RS02500 ENOG4105DIN metallophosphoesterase FOC65_RS02505 ENOG4105C6T cysteine synthase FOC65_RS02550 ENOG4108WQ6 secreted protein FOC65_RS02555 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FOC65_RS02575 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) FOC65_RS02600 ENOG4105C92 Aminotransferase class V FOC65_RS02610 ENOG4108V75 Glutamine amidotransferase FOC65_RS02615 ENOG4105E46 N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process FOC65_RS02640 ENOG4108NJC FOC65_RS02665 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) FOC65_RS02690 ENOG4108RU2 n-acetylmuramoyl-l-alanine amidase FOC65_RS02705 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase FOC65_RS02715 ENOG4105XT2 Transcriptional regulator FOC65_RS02740 ENOG4105CMR udp-glucose 4-epimerase FOC65_RS02750 ENOG4105CPQ Dehydrogenase FOC65_RS02765 ENOG4105DVA methyltransferase FOC65_RS02770 ENOG4105DQE DNA ligase FOC65_RS02825 ENOG4105CT3 Monooxygenase FOC65_RS02835 ENOG41066UM arsR family transcriptional regulator FOC65_RS02865 ENOG4105VT3 DNA binding domain protein, excisionase family FOC65_RS02880 ENOG4108Z6B deaminase FOC65_RS02890 ENOG4105EVN Prephenate dehydrogenase FOC65_RS02905 ENOG4105E90 ABC transporter FOC65_RS02910 ENOG4108IJ8 ABC transporter FOC65_RS02920 ENOG41060H3 Protein of unknown function (DUF1049) FOC65_RS02930 ENOG4105EUZ Beta-lactamase domain protein FOC65_RS02940 ENOG4105BZU Histidine kinase FOC65_RS02945 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC65_RS02995 ENOG4105CIH Imidazole acetol-phosphate transaminase FOC65_RS03060 ENOG4105C1B dTDP-glucose 4-6-dehydratase FOC65_RS03105 ENOG4105J1Z Arabinosyltransferase FOC65_RS03120 ENOG4107XDQ Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) FOC65_RS03125 ENOG4105C1G acyl-Coa dehydrogenase FOC65_RS03135 ENOG4105D8K carboxyl transferase FOC65_RS03145 ENOG4107RCI amp-dependent synthetase and ligase FOC65_RS03165 ENOG4107ISF Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component the mycobacterial cell wall. Catalyzes the transfer of arabinofuranosyl (Araf) residues residue from the sugar donor beta-D-arabinofuranosyl-1-monophosphoryldecaprenol (DPA) to the arabinan domain to form terminal beta-(1- 2)-linked Araf residues, which marks the end point for AG arabinan biosynthesis before decoration with mycolic acids FOC65_RS03180 ENOG410602S Transferase FOC65_RS03210 ENOG4108X4Q Hydrolase FOC65_RS03225 ENOG4105E9Q Acyl-transferase FOC65_RS03305 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) FOC65_RS03350 ENOG4108KGH TRANSCRIPTIONal FOC65_RS03445 ENOG4105DCG PHP domain protein FOC65_RS03460 ENOG4105CBC glutamate synthase FOC65_RS03495 ENOG4106BSN growth FOC65_RS03585 ENOG4106F1P AAA ATPase, central domain protein FOC65_RS03740 ENOG4108E1C hydrolase FOC65_RS03755 ENOG4107QJE Chromosome Partitioning Protein FOC65_RS03775 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) FOC65_RS03790 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) FOC65_RS03800 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) FOC65_RS03815 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FOC65_RS03860 ENOG4105XBB septation inhibitor protein FOC65_RS03880 ENOG4107TPY serine threonine protein kinase FOC65_RS03895 ENOG4108ZF3 Phosphatase FOC65_RS03905 ENOG4105TV9 FHA Domain-Containing protein FOC65_RS03915 ENOG4107QWG 2-Nitropropane dioxygenase FOC65_RS04030 ENOG4105DYW oxidoreductase FOC65_RS04040 ENOG4105CZA synthase FOC65_RS04050 ENOG41061MJ Domain of unknown function (DUF1707) FOC65_RS04060 ENOG4105BZ4 penicillin-binding protein FOC65_RS04100 ENOG4105CDU Replicative dna helicase FOC65_RS04120 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) FOC65_RS04125 ENOG4105DNP FAD linked oxidase domain protein FOC65_RS04135 ENOG4105DJZ UPF0182 protein FOC65_RS04155 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) FOC65_RS04160 ENOG41061TZ Short-chain dehydrogenase reductase Sdr FOC65_RS04175 ENOG4105EKQ RNA-directed DNA polymerase FOC65_RS04195 ENOG4105CI2 imidazolone-5-propionate hydrolase FOC65_RS04200 ENOG4105C87 Aminotransferase class I and II FOC65_RS04215 ENOG4108Q5F Tetr family transcriptional regulator FOC65_RS04245 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit FOC65_RS04255 ENOG4107TDF Formate hydrogenlyase subunit 4 FOC65_RS04265 ENOG4108JPZ Monovalent cation H antiporter subunit D FOC65_RS04270 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FOC65_RS04340 ENOG4105CEY Amp-dependent synthetase and ligase FOC65_RS04350 ENOG4105C59 p-type ATPase FOC65_RS04375 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic FOC65_RS04395 ENOG4105EXC Acyl-transferase FOC65_RS04425 ENOG4105FF0 ErfK YbiS YcfS YnhG FOC65_RS04430 ENOG4105C5Q Transcriptional regulator FOC65_RS04435 ENOG4105CFN oxalyl-CoA decarboxylase FOC65_RS04445 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) FOC65_RS04480 ENOG41070F3 Catalyzes the ATP-dependent phosphorylation of maltose to maltose 1-phosphate. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, GlgE and GlgB (By similarity) FOC65_RS04515 ENOG4105D74 hydrolase FOC65_RS04560 ENOG4105CMQ Chloride channel FOC65_RS04565 ENOG4105PF9 Transcriptional regulator FOC65_RS04580 ENOG4105C26 Dehydrogenase FOC65_RS04585 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr FOC65_RS04620 ENOG4105M2Z protein tyrosine serine phosphatase FOC65_RS04625 ENOG4105C1G acyl-Coa dehydrogenase FOC65_RS04635 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) FOC65_RS04640 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) FOC65_RS04645 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) FOC65_RS04655 ENOG4108R86 Transcriptional regulator FOC65_RS04670 ENOG4105CQB FAD linked oxidase domain protein FOC65_RS04690 ENOG4108WYP Transcriptional regulator FOC65_RS04700 ENOG4105CY3 ABC transporter, permease FOC65_RS04780 ENOG4105E5G Alpha beta hydrolase fold FOC65_RS04820 ENOG4105VPX protein, conserved in bacteria FOC65_RS04830 ENOG4105S7A ErfK ybiS ycfS ynhG family protein FOC65_RS04840 ENOG4105BZ1 (ABC) transporter FOC65_RS04855 ENOG4107QY8 reductase FOC65_RS04860 ENOG4105C9K Endothelin-converting enzyme 1 FOC65_RS04900 ENOG4107R13 MMPL domain protein FOC65_RS04945 ENOG4105C1G acyl-Coa dehydrogenase FOC65_RS04960 ENOG4105EQW The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) FOC65_RS04980 ENOG4105E39 Enoyl-CoA hydratase FOC65_RS04990 ENOG4108M6P methyltransferase FOC65_RS04995 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) FOC65_RS05040 ENOG4108CCU Ribonucleotide-diphosphate reductase subunit beta FOC65_RS05055 ENOG41073B4 coagulation factor 5 8 type domain-containing protein FOC65_RS05090 ENOG4105CHR reductase FOC65_RS05095 ENOG4105CHU acetyl-coa acetyltransferase FOC65_RS05100 ENOG4105CSU acyl-Coa dehydrogenase FOC65_RS05120 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) FOC65_RS05140 ENOG4107QZF nitrite reductase NADPH large subunit FOC65_RS05150 ENOG4108YZT Adenosylcobinamide kinase FOC65_RS05190 ENOG4107R7A Allophanate hydrolase subunit 2 FOC65_RS05210 ENOG4105DQQ Major facilitator superfamily MFS_1 FOC65_RS05215 ENOG4107CN4 Pfam:PhdYeFM FOC65_RS05230 ENOG4105CEY Amp-dependent synthetase and ligase FOC65_RS05235 ENOG4105D2B acyl-CoA dehydrogenase FOC65_RS05340 ENOG41090GG peptidase S8 and S53, subtilisin, kexin, sedolisin FOC65_RS05365 ENOG4105E0M Sulfatase FOC65_RS05385 ENOG4107DZG Ribbon-helix-helix protein, copG family FOC65_RS05410 ENOG4105E7Q Cob(II)yrinic acid a,c-diamide reductase FOC65_RS05420 ENOG4105YVM Phosphoesterase, PA-phosphatase related FOC65_RS05430 ENOG4105HMD FOC65_RS05495 ENOG4105C6Y Udp-glucose 6-dehydrogenase FOC65_RS05500 ENOG4105T1M mycothiol conjugate amidase mca FOC65_RS05505 ENOG41080HT Transcriptional regulator, arsr family FOC65_RS05525 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FOC65_RS05570 ENOG4105DF6 Fe-S oxidoreductase FOC65_RS05645 ENOG4105KNI merR family transcriptional Regulator FOC65_RS05675 ENOG4107XZ0 Peptidase M50 FOC65_RS05690 ENOG4105CJW magnesium transporter FOC65_RS05735 ENOG41085AN Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) FOC65_RS05775 ENOG41084UG Pfam:DUF1458 FOC65_RS05820 ENOG4107SPG Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR FOC65_RS05835 ENOG4105CEP NADH dehydrogenase FOC65_RS05880 ENOG4105C1G acyl-Coa dehydrogenase FOC65_RS05905 ENOG4108JA1 polyketide synthase FOC65_RS05935 ENOG4105CT1 (ABC) transporter FOC65_RS05975 ENOG4105IIU Aminopeptidase FOC65_RS06010 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic FOC65_RS06065 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FOC65_RS06120 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase FOC65_RS06240 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase FOC65_RS06265 ENOG4106BRA Membrane FOC65_RS06470 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FOC65_RS06500 ENOG4105EXC Acyl-transferase FOC65_RS06525 ENOG4105C85 amino acid FOC65_RS06540 ENOG4108RH7 phosphoglycerate mutase FOC65_RS06550 ENOG4107QIV Cytochrome c biogenesis protein FOC65_RS06560 ENOG4105CRE cytochrome C FOC65_RS06595 ENOG4107USC Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity) FOC65_RS06600 ENOG4108IAJ Nad-dependent epimerase dehydratase FOC65_RS06645 ENOG4105CJ3 phosphate transporter FOC65_RS06655 ENOG4105PDP Short chain dehydrogenase FOC65_RS06675 ENOG4105CEY Amp-dependent synthetase and ligase FOC65_RS06680 ENOG4105CI2 imidazolone-5-propionate hydrolase FOC65_RS06745 ENOG4105CT3 Monooxygenase FOC65_RS06775 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FOC65_RS06835 ENOG41090G8 Toxic component of a toxin-antitoxin (TA) module. A FOC65_RS06845 ENOG4105CWX Alpha-1,2-mannosidase FOC65_RS06900 ENOG4107PBH Toxic component of a toxin-antitoxin (TA) module. A FOC65_RS06920 ENOG4106FRU abrb family transcriptional regulator FOC65_RS06935 ENOG4105ETX regulatoR FOC65_RS07005 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving FOC65_RS07035 ENOG4105F0Z galactose-1-phosphate uridylyltransferase FOC65_RS07040 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) FOC65_RS07095 ENOG4105DSY exodeoxyribonuclease V, gamma FOC65_RS07110 ENOG4108151 Beta-lactamase domain protein FOC65_RS07140 ENOG4108F01 MaoC domain protein FOC65_RS07185 ENOG4108NUI synthase FOC65_RS07275 ENOG4107CD8 FOC65_RS07280 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) FOC65_RS07305 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FOC65_RS07315 ENOG4107R72 Ceramidase FOC65_RS07330 ENOG4105CSU acyl-Coa dehydrogenase FOC65_RS07360 ENOG410600Z Regulatory protein MarR FOC65_RS07435 ENOG4105XDV FOC65_RS07460 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) FOC65_RS07535 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) FOC65_RS07540 ENOG4105E6M Sulphatase-modifying factor protein FOC65_RS07595 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) FOC65_RS07615 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase FOC65_RS07620 ENOG4105C5I Dehydrogenase FOC65_RS07625 ENOG4105CMG Carbohydrate kinase FOC65_RS07770 ENOG4105C26 Dehydrogenase FOC65_RS07775 ENOG4105GCF PGAM FOC65_RS07800 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC65_RS07805 ENOG4105BZU Histidine kinase FOC65_RS07840 ENOG4105CHR reductase FOC65_RS07880 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) FOC65_RS07900 ENOG4105C83 adenylosuccinate lyase FOC65_RS07930 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC65_RS07940 ENOG4105CX0 fumarate reductase succinate dehydrogenase flavoprotein domain protein FOC65_RS07955 ENOG410839H phosphoribosylformylglycinamidine synthase FOC65_RS07975 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone FOC65_RS07980 ENOG4105CZE histidine utilization repressor FOC65_RS07985 ENOG41067V3 Antibiotic biosynthesis monooxygenase FOC65_RS08000 ENOG4107SVN transposase FOC65_RS08010 ENOG4105EZR dyp-type peroxidase family protein FOC65_RS08015 ENOG4105DFM M18 family aminopeptidase FOC65_RS08060 ENOG4105CXB phosphoribosylaminoimidazole synthetase FOC65_RS08070 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) FOC65_RS08085 ENOG4105PKJ carbohydrate binding FOC65_RS08105 ENOG4107NHD transcriptional regulator FOC65_RS08150 ENOG41082SX arsR family transcriptional regulator FOC65_RS08155 ENOG4108Z6B deaminase FOC65_RS08230 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) FOC65_RS08235 ENOG4107WD4 Releases the N-terminal proline from various substrates (By similarity) FOC65_RS08245 ENOG4108JYK Dehydrogenase FOC65_RS08260 ENOG4107R16 Multicopper oxidase FOC65_RS08270 ENOG410880H cysteine synthase FOC65_RS08325 ENOG4105CHU acetyl-coa acetyltransferase FOC65_RS08330 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FOC65_RS08355 ENOG4105EPU Molybdenum cofactor synthesis domain protein FOC65_RS08380 ENOG410901E Membrane FOC65_RS08385 ENOG4105VEQ Cold shock protein FOC65_RS08435 ENOG4105FCS tRNA rRNA methyltransferase FOC65_RS08605 ENOG4105CHU acetyl-coa acetyltransferase FOC65_RS08695 ENOG4105E2Z phosphate ABC transporter (Permease FOC65_RS08735 ENOG4105DQE DNA ligase FOC65_RS08795 ENOG4105DR5 peptidase FOC65_RS08800 ENOG4105CMV Succinyl-CoA synthetase subunit beta FOC65_RS08835 ENOG4105C0P Mg chelatase subunit ChlI FOC65_RS08885 ENOG41090WX Domain of unknown function (DUF1707) FOC65_RS08910 ENOG4105E39 Enoyl-CoA hydratase FOC65_RS08925 ENOG4107QX3 carboxylase FOC65_RS08965 ENOG4105ETX regulatoR FOC65_RS08970 ENOG41062D9 Histidine kinase FOC65_RS08980 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FOC65_RS09020 ENOG41080UU 5-formyltetrahydrofolate cyclo-ligase FOC65_RS09025 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FOC65_RS09060 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) FOC65_RS09065 ENOG410870F Cyclic nucleotide-binding protein FOC65_RS09105 ENOG4105CRQ synthase (Component I) FOC65_RS09115 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) FOC65_RS09120 ENOG4105F8V Hydrolase, tatD family FOC65_RS09145 ENOG4107RCI amp-dependent synthetase and ligase FOC65_RS09190 ENOG4105DXN mazG family FOC65_RS09225 ENOG4105C08 Histidine kinase FOC65_RS09255 ENOG4105BZU Histidine kinase FOC65_RS09260 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC65_RS09315 ENOG4105D5G Transposase FOC65_RS09335 ENOG41061TZ Short-chain dehydrogenase reductase Sdr FOC65_RS09375 ENOG4105CEY Amp-dependent synthetase and ligase FOC65_RS09455 ENOG4105CHU acetyl-coa acetyltransferase FOC65_RS09505 ENOG4105C7Z Conserved Protein FOC65_RS09565 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) FOC65_RS09575 ENOG4108IAB Phoh family FOC65_RS09655 ENOG4105C3G gtp-binding protein FOC65_RS09710 ENOG4108J5G 6-phosphogluconate dehydrogenase FOC65_RS09720 ENOG4108J2P Alpha beta hydrolase fold FOC65_RS09735 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) FOC65_RS09745 ENOG4105CFF transcriptional regulator FOC65_RS09780 ENOG4105CHU acetyl-coa acetyltransferase FOC65_RS09805 ENOG4108UKI Enoyl-CoA hydratase FOC65_RS09810 ENOG4105E39 Enoyl-CoA hydratase FOC65_RS09815 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F FOC65_RS09865 ENOG410905P Pyridoxamine 5-phosphate FOC65_RS09915 ENOG4108IUE nitrate reductase beta subunit FOC65_RS09980 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FOC65_RS09990 ENOG4108Z4U Ferredoxin FOC65_RS10030 ENOG4108K8K Transcriptional regulator FOC65_RS10035 ENOG4105C26 Dehydrogenase FOC65_RS10040 ENOG41062BK proline dehydrogenase FOC65_RS10050 ENOG4108KDQ Catalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds, leading to the formation of the corresponding primary alcohols, halide ions and protons (By similarity) FOC65_RS10065 ENOG4105CEY Amp-dependent synthetase and ligase FOC65_RS10095 ENOG4105D5G Transposase FOC65_RS10100 ENOG4105CSH Transporter FOC65_RS10120 ENOG4108URH decarboxylase FOC65_RS10145 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) FOC65_RS10180 ENOG4105DIM ABC transporter FOC65_RS10185 ENOG4105CIG ABC transporter FOC65_RS10190 ENOG4108X07 Tetr family transcriptional regulator FOC65_RS10205 ENOG4106684 FOC65_RS10210 ENOG4105C0H protease FOC65_RS10260 ENOG4105CJW magnesium transporter FOC65_RS10295 ENOG4105D7N magnesium and cobalt transport protein CorA FOC65_RS10330 ENOG4105VG9 Plasmid stabilization system FOC65_RS10335 ENOG410684T prevent-host-death family FOC65_RS10385 ENOG4105CQB FAD linked oxidase domain protein FOC65_RS10610 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) FOC65_RS10725 ENOG4105F8J Adenylate Guanylate cyclase FOC65_RS10730 ENOG4105CYV Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity) FOC65_RS10760 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) FOC65_RS10770 ENOG4108IUN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) FOC65_RS10780 ENOG4107RKP Nicotinate phosphoribosyltransferase FOC65_RS10820 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) FOC65_RS10970 ENOG4108Q50 Histidine kinase FOC65_RS11015 ENOG4105DU4 Sulfotransferase FOC65_RS11035 ENOG4105DXX methyltransferase FOC65_RS11110 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP FOC65_RS11115 ENOG4105F95 Monooxygenase FOC65_RS11275 ENOG4105EBR Carboxylesterase FOC65_RS11280 ENOG4105CEY Amp-dependent synthetase and ligase FOC65_RS11310 ENOG41069FZ L,D-transpeptidase catalytic domain FOC65_RS11365 ENOG4108J2R molybdopterin oxidoreductase FOC65_RS11400 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FOC65_RS11405 ENOG4105CV1 Transketolase (EC 2.2.1.1) FOC65_RS11430 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein FOC65_RS11455 ENOG4107JC6 Membrane FOC65_RS11470 ENOG4105JRK feS assembly protein SufD FOC65_RS11475 ENOG4105C3K feS assembly ATPase SufC FOC65_RS11485 ENOG4108UNV SUF system FeS assembly protein, NifU family FOC65_RS11490 ENOG4105VG1 fes assembly suf system protein FOC65_RS11495 ENOG4105C1G acyl-Coa dehydrogenase FOC65_RS11515 ENOG4105K63 Thioredoxin FOC65_RS11525 ENOG4105C5H ABC transporter FOC65_RS11535 ENOG4108Q5F Tetr family transcriptional regulator FOC65_RS11540 ENOG4107QM5 aconitate hydratase FOC65_RS11550 ENOG4105ZXU NLP P60 protein FOC65_RS11560 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FOC65_RS11570 ENOG4107QVM von Willebrand factor, type A FOC65_RS11595 ENOG4108UF8 FOC65_RS11660 ENOG4105G47 Methyltransferase, type 11 FOC65_RS11665 ENOG4105WKW Pfam:DUF1458 FOC65_RS11685 ENOG4108T5R FOC65_RS11720 ENOG4105C0K Gdp-mannose 4,6-dehydratase FOC65_RS11740 ENOG4105C0K Gdp-mannose 4,6-dehydratase FOC65_RS11745 ENOG4105C30 Nad-dependent epimerase dehydratase FOC65_RS11855 ENOG41067SE Tetr family transcriptional regulator FOC65_RS11905 ENOG4108W6C Dehydrogenase FOC65_RS12015 ENOG4105ZXU NLP P60 protein FOC65_RS12135 ENOG4108QB1 triacylglycerol lipase EC 3.1.1.3 FOC65_RS12185 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) FOC65_RS12195 ENOG4108MWI inositol mono-phosphatase FOC65_RS12270 ENOG4105C29 acyl-CoA thioesterase FOC65_RS12275 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) FOC65_RS12280 ENOG4108JJ9 ABC, transporter FOC65_RS12285 ENOG4108JJ9 ABC, transporter FOC65_RS12290 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FOC65_RS12295 ENOG4105C4M (Ubiquinol oxidase) subunit I FOC65_RS12370 ENOG4105C5X domain protein FOC65_RS12435 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) FOC65_RS12495 ENOG4108JA1 polyketide synthase FOC65_RS12500 ENOG4108JA1 polyketide synthase FOC65_RS12510 ENOG4108JA1 polyketide synthase FOC65_RS12510 ENOG4108JA1 polyketide synthase FOC65_RS12525 ENOG4105C5H ABC transporter FOC65_RS12530 ENOG4105C5H ABC transporter FOC65_RS12560 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) FOC65_RS12590 ENOG4105FDT acyl-CoA dehydrogenase FOC65_RS12595 ENOG4106ZX3 phosphonate ABC transporter, periplasmic phosphonate-binding protein FOC65_RS12615 ENOG4105W49 UPF0434 protein FOC65_RS12655 ENOG4105DSU hydrolase FOC65_RS12695 ENOG4108YZ4 nudix hydrolase FOC65_RS12740 ENOG4105CHH sulfate transporter FOC65_RS12755 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) FOC65_RS12875 ENOG41067QZ Membrane FOC65_RS12910 ENOG4107RBZ sulfate transporter FOC65_RS12950 ENOG4105IDI abc transporter atp-binding protein FOC65_RS12965 ENOG4105J5T Amp-dependent synthetase and ligase FOC65_RS12980 ENOG4105JWT ppe family FOC65_RS13055 ENOG4105XTG Pfam:DUF156 FOC65_RS13355 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) FOC65_RS13380 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor FOC65_RS13425 ENOG4107UAX integral membrane protein FOC65_RS13430 ENOG4105C37 (CBS) domain FOC65_RS13440 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) FOC65_RS13495 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone FOC65_RS13545 ENOG4105EMU Dehydrogenase FOC65_RS13555 ENOG4105CHU acetyl-coa acetyltransferase FOC65_RS13615 ENOG4105C5F glutamine synthetase FOC65_RS13635 ENOG4108IXY short-chain dehydrogenase reductase FOC65_RS13730 ENOG4107Z0Z A1pp FOC65_RS13735 ENOG4105F8J Adenylate Guanylate cyclase FOC65_RS13750 ENOG41082T9 Membrane FOC65_RS13845 ENOG4105FQP Beta-lactamase FOC65_RS13875 ENOG4105H9W Short-chain dehydrogenase reductase Sdr FOC65_RS13900 ENOG4105D2B acyl-CoA dehydrogenase FOC65_RS13905 ENOG4105CC9 acyl-Coa dehydrogenase FOC65_RS13920 ENOG4105F57 Anthranilate dioxygenase reductase FOC65_RS13935 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) FOC65_RS13940 ENOG4108R85 Short chain dehydrogenase FOC65_RS13945 ENOG4106USH transcriptional modulator of maze toxin, mazf FOC65_RS13955 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving FOC65_RS14175 ENOG41063C6 UPF0235 protein FOC65_RS14215 ENOG41076PI Short-chain dehydrogenase reductase Sdr FOC65_RS14365 ENOG4105G3V Inherit from COG: Protein of unknown function (DUF433) FOC65_RS14370 ENOG4106G8I FOC65_RS14380 ENOG4106F59 XRE family Transcriptional regulator FOC65_RS14385 ENOG4105XUP Phage derived protein Gp49-like (DUF891) FOC65_RS14400 ENOG4108F3G Type I restriction-modification system, R subunit FOC65_RS14450 ENOG4105MHT Transcriptional regulator, ARSR family FOC65_RS14475 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component FOC65_RS14480 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component FOC65_RS14495 ENOG4108RWI nicotinamidase FOC65_RS14505 ENOG4105EBR Carboxylesterase FOC65_RS14590 ENOG4105CTK cobaltochelatase, cobn subunit FOC65_RS14625 ENOG4108J4B Beta-lactamase FOC65_RS14650 ENOG4108RG3 short-chain dehydrogenase reductase FOC65_RS14685 ENOG4105MPZ Pfam:DUF1023 FOC65_RS14735 ENOG4105HFS 5'-3' exonuclease FOC65_RS14785 ENOG4105C0D helicase FOC65_RS14790 ENOG4107XWB Zinc finger, swim domain protein FOC65_RS14795 ENOG4105RYD Toxic component of a toxin-antitoxin (TA) module. A FOC65_RS14805 ENOG4105F7N Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) FOC65_RS14825 ENOG4105F7N Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) FOC65_RS14900 ENOG4105C3R Methionine synthase FOC65_RS14925 ENOG4108BAS reductase FOC65_RS14990 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) FOC65_RS15045 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) FOC65_RS15070 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) FOC65_RS15110 ENOG4105CJN penicillin-binding protein FOC65_RS15145 ENOG4105R14 (LipO)protein FOC65_RS15160 ENOG41090CE integral membrane protein FOC65_RS15165 ENOG4105KYH transcriptional regulatory protein FOC65_RS15180 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase FOC65_RS15210 ENOG4105D0U Arsenite-activated ATPase (ArsA) FOC65_RS15225 ENOG4108IQE Amp-dependent synthetase and ligase FOC65_RS15305 ENOG4107T4Z adenosine kinase FOC65_RS15335 ENOG410813T Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) FOC65_RS15360 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) FOC65_RS15435 ENOG4107DKM chad domain containing protein FOC65_RS15495 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) FOC65_RS15640 ENOG4105PDP Short chain dehydrogenase FOC65_RS15710 ENOG4106IDA glycerophosphoryl diester phosphodiesterase FOC65_RS15855 ENOG4107XR4 alpha beta FOC65_RS15880 ENOG4107P7U Inherit from COG: Protein of unknown function (DUF433) FOC65_RS15945 ENOG4105DRS transport system, permease FOC65_RS15960 ENOG4105CUB amino acid FOC65_RS15965 ENOG4105C8Y Acetylornithine aminotransferase FOC65_RS15970 ENOG4105C8Y Acetylornithine aminotransferase FOC65_RS15975 ENOG4105CIK Amidinotransferase FOC65_RS15980 ENOG4108VVK transcriptional Regulator, AsnC FOC65_RS16005 ENOG4105DQQ Major facilitator superfamily MFS_1 FOC65_RS16030 ENOG4105EDF drug resistance transporter, EmrB QacA subfamily FOC65_RS16040 ENOG4105D7W serine acetyltransferase FOC65_RS16055 ENOG4105CUZ uba thif-type nad fad binding protein FOC65_RS16265 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) FOC65_RS16280 ENOG4105WQT MbtH domain protein FOC65_RS16295 ENOG4105CEY Amp-dependent synthetase and ligase FOC65_RS16300 ENOG4107SQU synthase FOC65_RS16310 ENOG4105C0W non-ribosomal peptide synthetase FOC65_RS16315 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase FOC65_RS16375 ENOG4105EPD Oligopeptide transporter, Opt family FOC65_RS16400 ENOG4105ECW sulfate abc transporter FOC65_RS16405 ENOG4108I5D sulfate abc transporter FOC65_RS16410 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein FOC65_RS16425 ENOG4105BZP glycoside hydrolase 15-related FOC65_RS16450 ENOG4107XDQ Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) FOC65_RS16490 ENOG4105KQC Competence protein FOC65_RS16505 ENOG4108TZC FOC65_RS16515 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) FOC65_RS16520 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) FOC65_RS16545 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FOC65_RS16555 ENOG4105C5Q Transcriptional regulator FOC65_RS16575 ENOG4106EC3 ppe family FOC65_RS16595 ENOG4105D8X mechanosensitive ion channel FOC65_RS16600 ENOG4105BZU Histidine kinase FOC65_RS16605 ENOG4108RVA ribokinase FOC65_RS16620 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) FOC65_RS16640 ENOG4107QJT sodium dicarboxylate symporter FOC65_RS16645 ENOG4105C03 ribonuclease FOC65_RS16660 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase FOC65_RS16670 ENOG4105EG6 Saccharopine dehydrogenase FOC65_RS16695 ENOG4105DQU oxidoreductase, subunit beta FOC65_RS16700 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein FOC65_RS16710 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) FOC65_RS16715 ENOG4107QK5 Homocysteine s-methyltransferase FOC65_RS16735 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation FOC65_RS16750 ENOG4108A04 Beta-lactamase FOC65_RS16765 ENOG4105MC2 DSBA oxidoreductase FOC65_RS16795 ENOG4105CG3 alpha amylase, catalytic region FOC65_RS16820 ENOG4105C7I Dehydrogenase FOC65_RS16915 ENOG4105GP6 Toxic component of a toxin-antitoxin (TA) module. A FOC65_RS16920 ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 FOC65_RS16940 ENOG4105DJG MaoC domain protein dehydratase FOC65_RS16945 ENOG4105C1G acyl-Coa dehydrogenase FOC65_RS16955 ENOG4107QX3 carboxylase FOC65_RS16970 ENOG4105CEY Amp-dependent synthetase and ligase FOC65_RS16990 ENOG4105E1F short-chain dehydrogenase reductase FOC65_RS16995 ENOG4105D7A ATP-binding protein FOC65_RS17010 ENOG4105D5G Transposase FOC65_RS17045 ENOG4107UBC ErfK ybiS ycfS ynhG family protein FOC65_RS17085 ENOG4108WKN secreted protein FOC65_RS17100 ENOG4106H3A restriction FOC65_RS17135 ENOG410803B Involved in the transcription termination process (By similarity) FOC65_RS17240 ENOG4105HHA aminodeoxychorismate lyase FOC65_RS17250 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FOC65_RS17255 ENOG4107ZED Uncharacterised protein family UPF0047 FOC65_RS17305 ENOG4105NPQ Pfam:DUF403 FOC65_RS17390 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) FOC65_RS17395 ENOG4108NY6 Extracellular solute-binding protein, family 5 FOC65_RS17400 ENOG4107RTU Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FOC65_RS17420 ENOG4105E4E Thioester reductase domain-containing protein FOC65_RS17500 ENOG4105C29 acyl-CoA thioesterase FOC65_RS17520 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) FOC65_RS17530 ENOG4107YQ3 lipid a biosynthesis lauroyl acyltransferase FOC65_RS17560 ENOG4105PMW Domain of unknown function (DUF1990) FOC65_RS17695 ENOG41080HT Transcriptional regulator, arsr family FOC65_RS17705 ENOG4106FC9 Protein of unknown function (DUF3018) FOC65_RS17740 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FOC65_RS17875 ENOG4105E0X reductase FOC65_RS17945 ENOG4105U1W ABC transporter FOC65_RS17955 ENOG4105C0X amino acid FOC65_RS17960 ENOG4107VEG TrkA-N domain protein FOC65_RS18015 ENOG4105DFK Polyphosphate glucokinase FOC65_RS18105 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) FOC65_RS18125 ENOG4105C1G acyl-Coa dehydrogenase FOC65_RS18130 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FOC65_RS18160 ENOG4105C99 atpase involved in dna repair FOC65_RS18210 ENOG4105MXB limonene-12-epoxide hydrolase FOC65_RS18290 ENOG4105CVR type I restriction-modification system FOC65_RS18340 ENOG4105CHR reductase FOC65_RS18375 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) FOC65_RS18410 ENOG4105DCF alanine dehydrogenase FOC65_RS18415 ENOG4107QWG 2-Nitropropane dioxygenase FOC65_RS18455 ENOG4105C1G acyl-Coa dehydrogenase FOC65_RS18515 ENOG410839S Toxic component of a toxin-antitoxin (TA) module (By similarity) FOC65_RS18600 ENOG4108QA2 CRISPR-associated protein, Csm6 FOC65_RS18625 ENOG410695F Crispr-associated protein, Csm1 family FOC65_RS18660 ENOG41060JE PilT protein domain protein FOC65_RS18685 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component FOC65_RS18700 ENOG4105SFS phosphoesterase RecJ domain protein FOC65_RS18750 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FOC65_RS18760 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase FOC65_RS18795 ENOG4105D9G High-affinity FOC65_RS18805 ENOG4107RSS Hydrogenase accessory protein HypB FOC65_RS18820 ENOG4108Z86 Glutamine amidotransferase FOC65_RS18855 ENOG41067D0 Antitoxin component of a toxin-antitoxin (TA) module. Upon expression in M.smegmatis neutralizes the effect of toxin RelE2 FOC65_RS18860 ENOG4105VG9 Plasmid stabilization system FOC65_RS18905 ENOG4108HSG cytochrome biogenesis protein DipZ FOC65_RS18940 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) FOC65_RS18950 ENOG4107NHD transcriptional regulator FOC65_RS19085 ENOG4105DZ1 carboxypeptidase FOC65_RS19115 ENOG4105F8X type iii restriction FOC65_RS19120 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) FOC65_RS19200 ENOG4107EEY synthase FOC65_RS19295 ENOG4107RCI amp-dependent synthetase and ligase FOC65_RS19340 ENOG4105DHH glycosyltransferase MGT family FOC65_RS19365 ENOG4108M4U conserved membrane protein FOC65_RS19390 ENOG4106H78 methyltransferase FOC65_RS19395 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) FOC65_RS19415 ENOG4105CV8 reductase FOC65_RS19420 ENOG4105CV8 reductase FOC65_RS19435 ENOG4105DP4 dak2 domain fusion protein ylov FOC65_RS19475 ENOG4105CPF Cell wall formation (By similarity) FOC65_RS19480 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase FOC65_RS19510 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) FOC65_RS19540 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) FOC65_RS19545 ENOG4105ERH Fumarylacetoacetate hydrolase FOC65_RS19555 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) FOC65_RS19585 ENOG4105C4B ABC transporter, permease FOC65_RS19610 ENOG4108VGI doxx family FOC65_RS19640 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FOC65_RS19710 ENOG4105D5G Transposase FOC65_RS19770 ENOG4105EVB acetyltransferase FOC65_RS19775 ENOG4108V0V Pyrrolo-quinoline quinone FOC65_RS19805 ENOG4105DKW ABC transporter FOC65_RS19810 ENOG4105EAC phosphoserine phosphatase FOC65_RS19845 ENOG4107RN6 Monooxygenase FOC65_RS19850 ENOG4105EJ2 Transcriptional regulator FOC65_RS19900 ENOG4107YCY Transcriptional regulator FOC65_RS19905 ENOG4105D2B acyl-CoA dehydrogenase FOC65_RS19910 ENOG4107QIM DNA ligase FOC65_RS19915 ENOG4105D22 carbon starvation protein FOC65_RS20000 ENOG4105FBW Monooxygenase FOC65_RS20065 ENOG4105CKW Inner membrane protein yedI FOC65_RS20120 ENOG4107RYD Part of the ABC transporter FtsEX involved in cellular division (By similarity) FOC65_RS20125 ENOG4105CAK Cell division ATP-binding protein ftsE FOC65_RS20150 ENOG4105CQB FAD linked oxidase domain protein FOC65_RS20165 ENOG41090A4 Pterin carbinolamine dehydratase FOC65_RS20175 ENOG41067WU Molybdopterin converting factor (Subunit 1) FOC65_RS20190 ENOG4105D5G Transposase FOC65_RS20205 ENOG4105PKJ carbohydrate binding FOC65_RS20220 ENOG4106P4H Cytochrome P450 FOC65_RS20315 ENOG4107TK4 histidinol-phosphate phosphatase FOC65_RS20330 ENOG4105C1G acyl-Coa dehydrogenase FOC65_RS20385 ENOG4108IEH NADH dehydrogenase subunit g FOC65_RS20400 ENOG4105DF2 NADH dehydrogenase subunit j FOC65_RS20450 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FOC65_RS20500 ENOG4108JGH Tetr family transcriptional regulator FOC65_RS20510 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FOC65_RS20550 ENOG4105XUP Phage derived protein Gp49-like (DUF891) FOC65_RS20555 ENOG4106F59 XRE family Transcriptional regulator FOC65_RS20595 ENOG4105F9F transposase FOC65_RS20615 ENOG4105DJZ UPF0182 protein FOC65_RS20645 ENOG4105WBQ Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) FOC65_RS20660 ENOG4105E09 nadh pyrophosphatase