locus-tag	class	description
EFV83_RS00010	COG2161	toxin-antitoxin pair type II binding
EFV83_RS00015	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
EFV83_RS00095	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
EFV83_RS00100	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EFV83_RS00110	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
EFV83_RS00120	COG1758	RNA polymerase activity
EFV83_RS00140	COG0284	orotidine-5'-phosphate decarboxylase activity
EFV83_RS00145	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EFV83_RS00150	COG0505	Belongs to the CarA family
EFV83_RS00170	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
EFV83_RS00190	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EFV83_RS00200	COG0006	proline dipeptidase activity
EFV83_RS00215	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
EFV83_RS00220	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EFV83_RS00235	COG4106	trans-aconitate 2-methyltransferase activity
EFV83_RS00250	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EFV83_RS00265	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EFV83_RS00315	COG0701	Predicted permease
EFV83_RS00340	COG2272	Belongs to the type-B carboxylesterase lipase family
EFV83_RS00380	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EFV83_RS00390	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EFV83_RS00400	COG0747	negative chemotaxis
EFV83_RS00405	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EFV83_RS00420	COG2255	four-way junction helicase activity
EFV83_RS00430	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
EFV83_RS00465	COG1946	Acyl-CoA thioesterase
EFV83_RS00470	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
EFV83_RS00480	COG0438	transferase activity, transferring glycosyl groups
EFV83_RS00520	COG4762	Protein conserved in bacteria
EFV83_RS00575	COG1309	transcriptional regulator
EFV83_RS00605	COG3878	Protein conserved in bacteria
EFV83_RS00660	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EFV83_RS00675	COG1529	Aldehyde oxidase and xanthine dehydrogenase
EFV83_RS00675	COG2080	2 iron, 2 sulfur cluster binding
EFV83_RS00690	COG0402	S-adenosylhomocysteine deaminase activity
EFV83_RS00710	COG2233	PERMEase
EFV83_RS00730	COG1953	Uracil, thiamine, allantoin
EFV83_RS00740	COG1301	dicarboxylic acid transport
EFV83_RS00750	COG4266	Belongs to the allantoicase family
EFV83_RS00780	COG2267	carboxylic ester hydrolase activity
EFV83_RS00785	COG1960	acyl-CoA dehydrogenase activity
EFV83_RS00790	COG1028	Short-chain dehydrogenase reductase Sdr
EFV83_RS00805	COG0183	Belongs to the thiolase family
EFV83_RS00825	COG0501	Belongs to the peptidase M48B family
EFV83_RS00840	COG0477	Major facilitator Superfamily
EFV83_RS00895	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
EFV83_RS00905	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EFV83_RS00945	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EFV83_RS00975	COG3253	May function as heme-dependent peroxidase
EFV83_RS00980	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
EFV83_RS00985	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
EFV83_RS00995	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
EFV83_RS01010	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EFV83_RS01015	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EFV83_RS01020	COG0531	amino acid
EFV83_RS01025	COG0569	domain protein
EFV83_RS01060	COG0702	epimerase
EFV83_RS01075	COG0756	dUTP diphosphatase activity
EFV83_RS01120	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EFV83_RS01170	COG3220	belongs to the UPF0276 family
EFV83_RS01245	COG1388	LysM domain
EFV83_RS01260	COG1960	acyl-CoA dehydrogenase activity
EFV83_RS01270	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EFV83_RS01290	COG1196	nuclear chromosome segregation
EFV83_RS01310	COG1126	abc transporter atp-binding protein
EFV83_RS01315	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EFV83_RS01320	COG0765	amino acid transport
EFV83_RS01325	COG0765	amino acid transport
EFV83_RS01375	COG4308	Limonene-1,2-epoxide hydrolase catalytic domain
EFV83_RS01380	COG4308	Limonene-1,2-epoxide hydrolase catalytic domain
EFV83_RS01395	COG1842	Phage shock protein A
EFV83_RS01400	COG1396	sequence-specific DNA binding
EFV83_RS01410	COG1028	Short-chain dehydrogenase reductase Sdr
EFV83_RS01420	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
EFV83_RS01475	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
EFV83_RS01480	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EFV83_RS01495	COG3214	Protein conserved in bacteria
EFV83_RS01535	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
EFV83_RS01545	COG0659	secondary active sulfate transmembrane transporter activity
EFV83_RS01555	COG0686	Belongs to the AlaDH PNT family
EFV83_RS01570	COG1028	Short-chain dehydrogenase reductase Sdr
EFV83_RS01640	COG2977	Belongs to the P-Pant transferase superfamily
EFV83_RS01645	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
EFV83_RS01665	COG1960	acyl-CoA dehydrogenase activity
EFV83_RS01670	COG1960	acyl-CoA dehydrogenase activity
EFV83_RS01675	COG1024	Enoyl-CoA hydratase
EFV83_RS01700	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
EFV83_RS01725	COG1017	nitric oxide dioxygenase activity
EFV83_RS01725	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EFV83_RS01730	COG1959	2 iron, 2 sulfur cluster binding
EFV83_RS01775	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EFV83_RS01775	COG1648	precorrin-2 dehydrogenase activity
EFV83_RS01805	COG1028	Short-chain dehydrogenase reductase Sdr
EFV83_RS01805	COG0604	alcohol dehydrogenase
EFV83_RS01805	COG3321	synthase
EFV83_RS01865	COG0579	oxidoreductase
EFV83_RS01885	COG1492	cobalamin metabolic process
EFV83_RS01895	COG1376	ErfK ybiS ycfS ynhG family protein
EFV83_RS01920	COG0750	zinc metalloprotease
EFV83_RS01945	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EFV83_RS02010	COG0528	UMP kinase activity
EFV83_RS02015	COG3973	AAA domain
EFV83_RS02030	COG2723	6-phospho-beta-galactosidase activity
EFV83_RS02065	COG1309	transcriptional regulator
EFV83_RS02105	COG0583	DNA-binding transcription factor activity
EFV83_RS02135	COG0792	nuclease activity
EFV83_RS02195	COG0336	Belongs to the RNA methyltransferase TrmD family
EFV83_RS02235	COG1686	Belongs to the peptidase S11 family
EFV83_RS02255	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
EFV83_RS02275	COG1304	FMN binding
EFV83_RS02300	COG1254	Belongs to the acylphosphatase family
EFV83_RS02325	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
EFV83_RS02330	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
EFV83_RS02350	COG0571	ribonuclease III activity
EFV83_RS02360	COG3599	regulation of cell shape
EFV83_RS02400	COG0742	ribosomal rna small subunit methyltransferase
EFV83_RS02405	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
EFV83_RS02420	COG0657	acetylesterase activity
EFV83_RS02425	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EFV83_RS02445	COG2124	cytochrome p450
EFV83_RS02460	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EFV83_RS02465	COG1461	Dihydroxyacetone kinase
EFV83_RS02475	COG1024	Enoyl-CoA hydratase
EFV83_RS02500	COG1181	Belongs to the D-alanine--D-alanine ligase family
EFV83_RS02505	COG0626	cystathionine gamma-synthase activity
EFV83_RS02510	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
EFV83_RS02575	COG0179	Fumarylacetoacetate (FAA) hydrolase
EFV83_RS02590	COG2271	Major facilitator Superfamily
EFV83_RS02625	COG0583	DNA-binding transcription factor activity
EFV83_RS02635	COG0778	Nitroreductase
EFV83_RS02650	COG1309	transcriptional regulator
EFV83_RS02655	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
EFV83_RS02660	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
EFV83_RS02665	COG2124	cytochrome p450
EFV83_RS02700	COG0440	acetolactate synthase activity
EFV83_RS02715	COG1748	Saccharopine dehydrogenase
EFV83_RS02720	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EFV83_RS02740	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EFV83_RS02760	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EFV83_RS02770	COG2272	Belongs to the type-B carboxylesterase lipase family
EFV83_RS02785	COG0745	RESPONSE REGULATOR receiver
EFV83_RS02790	COG2205	protein histidine kinase activity
EFV83_RS02815	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
EFV83_RS02845	COG1024	Enoyl-CoA hydratase
EFV83_RS02850	COG0778	Nitroreductase
EFV83_RS02860	COG2252	PERMEase
EFV83_RS02900	COG2197	response regulator
EFV83_RS02905	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
EFV83_RS02915	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EFV83_RS02940	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
EFV83_RS02955	COG1309	transcriptional regulator
EFV83_RS02985	COG0110	maltose O-acetyltransferase activity
EFV83_RS02990	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EFV83_RS03015	COG1119	ATPase activity
EFV83_RS03025	COG2364	Membrane
EFV83_RS03030	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EFV83_RS03045	COG4607	ABC-type enterochelin transport system periplasmic component
EFV83_RS03095	COG1064	alcohol dehydrogenase
EFV83_RS03115	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EFV83_RS03120	COG1028	Short-chain dehydrogenase reductase Sdr
EFV83_RS03185	COG0477	Major facilitator Superfamily
EFV83_RS03205	COG1028	Short-chain dehydrogenase reductase Sdr
EFV83_RS03235	COG1028	Short-chain dehydrogenase reductase Sdr
EFV83_RS03260	COG1335	isochorismatase
EFV83_RS03270	COG2855	membrane
EFV83_RS03280	COG0318	PFAM AMP-dependent synthetase and ligase
EFV83_RS03295	COG1028	Short-chain dehydrogenase reductase Sdr
EFV83_RS03305	COG1028	Short-chain dehydrogenase reductase Sdr
EFV83_RS03310	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
EFV83_RS03375	COG2272	Belongs to the type-B carboxylesterase lipase family
EFV83_RS03390	COG0183	Belongs to the thiolase family
EFV83_RS03425	COG1309	transcriptional regulator
EFV83_RS03455	COG0789	Transcriptional regulator
EFV83_RS03465	COG0028	Belongs to the TPP enzyme family
EFV83_RS03490	COG2177	Part of the ABC transporter FtsEX involved in
EFV83_RS03495	COG2884	Cell division ATP-binding protein ftsE
EFV83_RS03505	COG0668	transmembrane transport
EFV83_RS03545	COG0483	inositol monophosphate 1-phosphatase activity
EFV83_RS03550	COG1960	acyl-CoA dehydrogenase activity
EFV83_RS03555	COG1960	acyl-CoA dehydrogenase activity
EFV83_RS03570	COG0318	PFAM AMP-dependent synthetase and ligase
EFV83_RS03580	COG0542	response to heat
EFV83_RS03625	COG3480	Lon protease (S16) C-terminal proteolytic domain
EFV83_RS03630	COG3011	Protein conserved in bacteria
EFV83_RS03645	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
EFV83_RS03650	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
EFV83_RS03660	COG0300	oxidoreductase activity
EFV83_RS03665	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
EFV83_RS03700	COG0475	glutathione-regulated potassium exporter activity
EFV83_RS03700	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EFV83_RS03715	COG0596	Alpha beta hydrolase
EFV83_RS03730	COG0745	RESPONSE REGULATOR receiver
EFV83_RS03740	COG2146	nitrite reductase [NAD(P)H] activity
EFV83_RS03740	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EFV83_RS03745	COG2223	nitrite transmembrane transporter activity
EFV83_RS03785	COG0513	Belongs to the DEAD box helicase family
EFV83_RS03800	COG0406	alpha-ribazole phosphatase activity
EFV83_RS03820	COG1597	lipid kinase activity
EFV83_RS03835	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
EFV83_RS03855	COG1595	DNA-templated transcription, initiation
EFV83_RS03860	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
EFV83_RS03865	COG2135	peptidase activity
EFV83_RS03870	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
EFV83_RS03875	COG1162	GTPase activity
EFV83_RS03910	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EFV83_RS04005	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EFV83_RS04010	COG0604	alcohol dehydrogenase
EFV83_RS04010	COG3321	synthase
EFV83_RS04015	COG0604	alcohol dehydrogenase
EFV83_RS04015	COG3321	synthase
EFV83_RS04020	COG1960	acyl-CoA dehydrogenase activity
EFV83_RS04030	COG0318	PFAM AMP-dependent synthetase and ligase
EFV83_RS04035	COG0653	protein targeting
EFV83_RS04045	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EFV83_RS04050	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
EFV83_RS04060	COG1309	transcriptional regulator
EFV83_RS04075	COG5401	PFAM Sporulation and spore germination
EFV83_RS04080	COG5002	protein histidine kinase activity
EFV83_RS04090	COG0318	PFAM AMP-dependent synthetase and ligase
EFV83_RS04095	COG1285	pathogenesis
EFV83_RS04125	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EFV83_RS04130	COG0531	amino acid
EFV83_RS04140	COG1482	cell wall glycoprotein biosynthetic process
EFV83_RS04170	COG0391	Required for morphogenesis under gluconeogenic growth conditions
EFV83_RS04175	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
EFV83_RS04175	COG0778	Nitroreductase
EFV83_RS04190	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
EFV83_RS04205	COG1316	TRANSCRIPTIONal
EFV83_RS04225	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
EFV83_RS04235	COG2175	clavaminate synthase activity
EFV83_RS04260	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
EFV83_RS04260	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
EFV83_RS04270	COG0318	PFAM AMP-dependent synthetase and ligase
EFV83_RS04285	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EFV83_RS04305	COG3265	gluconokinase activity
EFV83_RS04310	COG1960	acyl-CoA dehydrogenase activity
EFV83_RS04325	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EFV83_RS04345	COG4770	biotin carboxylase activity
EFV83_RS04355	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
EFV83_RS04375	COG1012	belongs to the aldehyde dehydrogenase family
EFV83_RS04380	COG1309	transcriptional regulator
EFV83_RS04385	COG1201	RNA secondary structure unwinding
EFV83_RS04400	COG0564	pseudouridine synthase activity
EFV83_RS04420	COG1473	amidohydrolase
EFV83_RS04420	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
EFV83_RS04435	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EFV83_RS04450	COG0791	NLP P60 protein
EFV83_RS04450	COG3883	PFAM NLP P60 protein
EFV83_RS04495	COG2009	succinate dehydrogenase
EFV83_RS04510	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EFV83_RS04515	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EFV83_RS04520	COG1595	DNA-templated transcription, initiation
EFV83_RS04535	COG1686	Belongs to the peptidase S11 family
EFV83_RS04550	COG0708	Exodeoxyribonuclease III
EFV83_RS04610	COG1733	regulation of RNA biosynthetic process
EFV83_RS04615	COG2910	NAD(P)H-binding
EFV83_RS04620	COG0842	Transport permease protein
EFV83_RS04620	COG1131	(ABC) transporter
EFV83_RS04620	COG1716	ATPase activity
EFV83_RS04625	COG1357	PFAM Pentapeptide repeats (8 copies)
EFV83_RS04640	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
EFV83_RS04645	COG0587	DNA-directed DNA polymerase activity
EFV83_RS04650	COG1073	alpha beta
EFV83_RS04655	COG1309	transcriptional regulator
EFV83_RS04720	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EFV83_RS04720	COG0519	Catalyzes the synthesis of GMP from XMP
EFV83_RS04730	COG0516	GMP reductase activity
EFV83_RS04790	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EFV83_RS04805	COG0456	acetyltransferase
EFV83_RS04825	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EFV83_RS04830	COG0076	glutamate decarboxylase activity
EFV83_RS04840	COG2267	carboxylic ester hydrolase activity
EFV83_RS04845	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EFV83_RS04870	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EFV83_RS04880	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EFV83_RS04885	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
EFV83_RS04920	COG1404	Belongs to the peptidase S8 family
EFV83_RS04950	COG2267	carboxylic ester hydrolase activity
EFV83_RS05005	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
EFV83_RS05010	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EFV83_RS05020	COG2268	Band 7 protein
EFV83_RS05030	COG1088	dTDP-glucose 4,6-dehydratase activity
EFV83_RS05035	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
EFV83_RS05080	COG0616	signal peptide processing
EFV83_RS05095	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EFV83_RS05115	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
EFV83_RS05125	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
EFV83_RS05140	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
EFV83_RS05155	COG2272	Belongs to the type-B carboxylesterase lipase family
EFV83_RS05180	COG0477	Major facilitator Superfamily
EFV83_RS05195	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
EFV83_RS05235	COG0088	Forms part of the polypeptide exit tunnel
EFV83_RS05240	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
EFV83_RS05245	COG0051	transcription antitermination factor activity, RNA binding
EFV83_RS05285	COG0531	amino acid
EFV83_RS05315	COG0535	radical SAM domain protein
EFV83_RS05340	COG1834	amidinotransferase
EFV83_RS05345	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EFV83_RS05350	COG0531	amino acid
EFV83_RS05395	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
EFV83_RS05400	COG1309	transcriptional regulator
EFV83_RS05425	COG1024	Enoyl-CoA hydratase
EFV83_RS05440	COG1960	acyl-CoA dehydrogenase activity
EFV83_RS05470	COG1113	amino acid transport
EFV83_RS05485	COG0085	RNA polymerase activity
EFV83_RS05490	COG0243	molybdopterin cofactor binding
EFV83_RS05550	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EFV83_RS05565	COG0277	FAD linked oxidase domain protein
EFV83_RS05585	COG4941	Belongs to the sigma-70 factor family
EFV83_RS05620	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EFV83_RS05660	COG0783	Belongs to the Dps family
EFV83_RS05665	COG0693	protein deglycase activity
EFV83_RS05710	COG1404	Belongs to the peptidase S8 family
EFV83_RS05730	COG1280	lysine exporter protein (LysE YggA)
EFV83_RS05800	COG0501	Belongs to the peptidase M48B family
EFV83_RS05805	COG0142	geranyltranstransferase activity
EFV83_RS05810	COG0644	oxidoreductase
EFV83_RS05820	COG0438	transferase activity, transferring glycosyl groups
EFV83_RS05840	COG4948	Mandelate Racemase Muconate Lactonizing
EFV83_RS05865	COG3706	GGDEF domain
EFV83_RS05880	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EFV83_RS05890	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
EFV83_RS05895	COG1028	Short-chain dehydrogenase reductase Sdr
EFV83_RS05900	COG4221	oxidoreductase activity
EFV83_RS05950	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
EFV83_RS05955	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EFV83_RS05965	COG0542	response to heat
EFV83_RS05995	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EFV83_RS06040	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EFV83_RS06045	COG1333	cytochrome c biogenesis protein
EFV83_RS06050	COG0785	Cytochrome C biogenesis protein
EFV83_RS06060	COG0406	alpha-ribazole phosphatase activity
EFV83_RS06080	COG3590	peptidase
EFV83_RS06130	COG1587	Uroporphyrinogen-III synthase
EFV83_RS06130	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EFV83_RS06155	COG2030	dehydratase
EFV83_RS06180	COG2070	2-Nitropropane dioxygenase
EFV83_RS06205	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EFV83_RS06210	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EFV83_RS06315	COG1309	transcriptional regulator
EFV83_RS06325	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EFV83_RS06375	COG2072	flavoprotein involved in K transport
EFV83_RS06390	COG2072	flavoprotein involved in K transport
EFV83_RS06395	COG1028	Short-chain dehydrogenase reductase Sdr
EFV83_RS06400	COG0657	acetylesterase activity
EFV83_RS06405	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
EFV83_RS06415	COG0745	RESPONSE REGULATOR receiver
EFV83_RS06420	COG5002	protein histidine kinase activity
EFV83_RS06430	COG2072	flavoprotein involved in K transport
EFV83_RS06445	COG0300	oxidoreductase activity
EFV83_RS06500	COG2814	Major facilitator Superfamily
EFV83_RS06505	COG0812	UDP-N-acetylmuramate dehydrogenase activity
EFV83_RS06600	COG2733	membrane
EFV83_RS06610	COG2326	polyphosphate kinase activity
EFV83_RS06615	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EFV83_RS06650	COG2224	Isocitrate lyase
EFV83_RS06690	COG2226	methyltransferase
EFV83_RS06740	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
EFV83_RS06775	COG0667	Aldo Keto reductase
EFV83_RS06800	COG4552	Acetyltransferase involved in intracellular survival and related
EFV83_RS06805	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EFV83_RS06830	COG1505	serine-type exopeptidase activity
EFV83_RS06850	COG1073	alpha beta
EFV83_RS06855	COG2326	polyphosphate kinase activity
EFV83_RS06870	COG2223	nitrite transmembrane transporter activity
EFV83_RS06875	COG0640	Transcriptional regulator
EFV83_RS06905	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
EFV83_RS06925	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EFV83_RS06950	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EFV83_RS06955	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EFV83_RS06960	COG1028	Short-chain dehydrogenase reductase Sdr
EFV83_RS06970	COG1960	acyl-CoA dehydrogenase activity
EFV83_RS06975	COG1960	acyl-CoA dehydrogenase activity
EFV83_RS06980	COG0318	PFAM AMP-dependent synthetase and ligase
EFV83_RS06990	COG2070	2-Nitropropane dioxygenase
EFV83_RS07000	COG1024	Enoyl-CoA hydratase
EFV83_RS07005	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
EFV83_RS07010	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EFV83_RS07045	COG4638	Rieske (2fe-2S)
EFV83_RS07085	COG0175	sulfate reduction
EFV83_RS07155	COG2814	Major facilitator Superfamily
EFV83_RS07165	COG0351	phosphomethylpyrimidine kinase
EFV83_RS07175	COG1252	NADH dehydrogenase
EFV83_RS07185	COG1309	transcriptional regulator
EFV83_RS07195	COG1012	belongs to the aldehyde dehydrogenase family
EFV83_RS07230	COG0494	nUDIX hydrolase
EFV83_RS07240	COG2234	aminopeptidase activity
EFV83_RS07245	COG2234	aminopeptidase activity
EFV83_RS07255	COG1131	(ABC) transporter
EFV83_RS07260	COG2022	thiamine diphosphate biosynthetic process
EFV83_RS07295	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EFV83_RS07300	COG0515	serine threonine protein kinase
EFV83_RS07305	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
EFV83_RS07335	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EFV83_RS07340	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EFV83_RS07345	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EFV83_RS07350	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EFV83_RS07360	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EFV83_RS07365	COG1126	abc transporter atp-binding protein
EFV83_RS07405	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
EFV83_RS07440	COG1994	Peptidase M50
EFV83_RS07460	COG0586	Pfam SNARE associated Golgi protein
EFV83_RS07490	COG4221	oxidoreductase activity
EFV83_RS07510	COG0542	response to heat
EFV83_RS07535	COG0789	Transcriptional regulator
EFV83_RS07540	COG0484	heat shock protein binding
EFV83_RS07545	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
EFV83_RS07620	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EFV83_RS07620	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EFV83_RS07660	COG0247	lactate metabolic process
EFV83_RS07660	COG2181	nitrate reductase activity
EFV83_RS07670	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
EFV83_RS07710	COG3345	alpha-galactosidase
EFV83_RS07715	COG1262	PFAM Formylglycine-generating sulfatase enzyme
EFV83_RS07720	COG1305	Transglutaminase-like
EFV83_RS07735	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EFV83_RS07815	COG1012	belongs to the aldehyde dehydrogenase family
EFV83_RS07825	COG0454	-acetyltransferase
EFV83_RS07880	COG1028	Short-chain dehydrogenase reductase Sdr
EFV83_RS07885	COG1960	acyl-CoA dehydrogenase activity
EFV83_RS07900	COG3268	Saccharopine dehydrogenase
EFV83_RS07905	COG0318	PFAM AMP-dependent synthetase and ligase
EFV83_RS07910	COG3285	dna ligase
EFV83_RS07910	COG1793	dna ligase
EFV83_RS07915	COG0494	nUDIX hydrolase
EFV83_RS07925	COG2902	Dehydrogenase
EFV83_RS07930	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EFV83_RS07945	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EFV83_RS07965	COG1309	transcriptional regulator
EFV83_RS07980	COG0778	Nitroreductase
EFV83_RS07985	COG0179	Fumarylacetoacetate (FAA) hydrolase
EFV83_RS08010	COG0179	Fumarylacetoacetate (FAA) hydrolase
EFV83_RS08015	COG0318	PFAM AMP-dependent synthetase and ligase
EFV83_RS08020	COG1396	sequence-specific DNA binding
EFV83_RS08025	COG1414	Transcriptional regulator
EFV83_RS08040	COG2267	carboxylic ester hydrolase activity
EFV83_RS08045	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
EFV83_RS08060	COG4638	Rieske (2fe-2S)
EFV83_RS08065	COG0604	alcohol dehydrogenase
EFV83_RS08065	COG3321	synthase
EFV83_RS08065	COG1028	Short-chain dehydrogenase reductase Sdr
EFV83_RS08070	COG3384	dioxygenase
EFV83_RS08075	COG3971	2-oxopent-4-enoate hydratase activity
EFV83_RS08090	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EFV83_RS08095	COG0318	PFAM AMP-dependent synthetase and ligase
EFV83_RS08135	COG1309	transcriptional regulator
EFV83_RS08160	COG1309	transcriptional regulator
EFV83_RS08165	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
EFV83_RS08180	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
EFV83_RS08185	COG1984	allophanate hydrolase subunit 2
EFV83_RS08250	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
EFV83_RS08255	COG1802	Transcriptional regulator
EFV83_RS08285	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EFV83_RS08295	COG0473	3-isopropylmalate dehydrogenase activity
EFV83_RS08310	COG1053	succinate dehydrogenase
EFV83_RS08330	COG0640	Transcriptional regulator
EFV83_RS08380	COG2318	DinB family
EFV83_RS08385	COG1960	acyl-CoA dehydrogenase activity
EFV83_RS08400	COG1660	Displays ATPase and GTPase activities
EFV83_RS08410	COG0183	Belongs to the thiolase family
EFV83_RS08415	COG1028	Short-chain dehydrogenase reductase Sdr
EFV83_RS08420	COG2030	dehydratase
EFV83_RS08435	COG0659	secondary active sulfate transmembrane transporter activity
EFV83_RS08440	COG1309	transcriptional regulator
EFV83_RS08445	COG0861	Integral membrane protein TerC family
EFV83_RS08470	COG0318	PFAM AMP-dependent synthetase and ligase
EFV83_RS08485	COG1472	Belongs to the glycosyl hydrolase 3 family
EFV83_RS08490	COG4941	Belongs to the sigma-70 factor family
EFV83_RS08555	COG4981	capsule polysaccharide biosynthetic process
EFV83_RS08595	COG0438	transferase activity, transferring glycosyl groups
EFV83_RS08640	COG1250	3-hydroxyacyl-CoA dehydrogenase
EFV83_RS08685	COG2197	response regulator
EFV83_RS08690	COG3850	Histidine kinase
EFV83_RS08710	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
EFV83_RS08740	COG2409	Drug exporters of the RND superfamily
EFV83_RS08785	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EFV83_RS08795	COG2197	response regulator
EFV83_RS08825	COG2353	YceI-like domain
EFV83_RS08845	COG2409	Drug exporters of the RND superfamily
EFV83_RS08860	COG4552	Acetyltransferase involved in intracellular survival and related
EFV83_RS08865	COG1832	CoA-binding protein
EFV83_RS08880	COG3590	peptidase
EFV83_RS08885	COG1376	ErfK ybiS ycfS ynhG family protein
EFV83_RS08890	COG1960	acyl-CoA dehydrogenase activity
EFV83_RS08900	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EFV83_RS08910	COG1937	Protein conserved in bacteria
EFV83_RS08935	COG1012	belongs to the aldehyde dehydrogenase family
EFV83_RS08940	COG4122	O-methyltransferase activity
EFV83_RS08955	COG2267	carboxylic ester hydrolase activity
EFV83_RS08985	COG1704	LemA family
EFV83_RS08995	COG0318	PFAM AMP-dependent synthetase and ligase
EFV83_RS09050	COG1024	Enoyl-CoA hydratase
EFV83_RS09055	COG1802	Transcriptional regulator
EFV83_RS09065	COG2267	carboxylic ester hydrolase activity
EFV83_RS09070	COG1309	transcriptional regulator
EFV83_RS09100	COG0435	Glutathione S-transferase
EFV83_RS09140	COG1024	Enoyl-CoA hydratase
EFV83_RS09150	COG2211	Major facilitator Superfamily
EFV83_RS09155	COG2365	Tyrosine phosphatase family
EFV83_RS09220	COG1028	Short-chain dehydrogenase reductase Sdr
EFV83_RS09225	COG1012	belongs to the aldehyde dehydrogenase family
EFV83_RS09240	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EFV83_RS09245	COG1960	acyl-CoA dehydrogenase activity
EFV83_RS09250	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
EFV83_RS09265	COG2226	methyltransferase
EFV83_RS09280	COG1396	sequence-specific DNA binding
EFV83_RS09280	COG3800	Transcriptional regulator
EFV83_RS09290	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
EFV83_RS09330	COG0318	PFAM AMP-dependent synthetase and ligase
EFV83_RS09390	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
EFV83_RS09400	COG0129	dihydroxy-acid dehydratase activity
EFV83_RS09420	COG2186	Transcriptional regulator
EFV83_RS09450	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EFV83_RS09455	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EFV83_RS09465	COG0723	plastoquinol--plastocyanin reductase activity
EFV83_RS09485	COG1028	Short-chain dehydrogenase reductase Sdr
EFV83_RS09525	COG1028	Short-chain dehydrogenase reductase Sdr
EFV83_RS09540	COG0318	PFAM AMP-dependent synthetase and ligase
EFV83_RS09545	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EFV83_RS09550	COG1136	(ABC) transporter
EFV83_RS09560	COG1104	cysteine desulfurase activity
EFV83_RS09625	COG1309	transcriptional regulator
EFV83_RS09635	COG1819	glycosyl
EFV83_RS09655	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EFV83_RS09680	COG1819	glycosyl
EFV83_RS09795	COG3263	regulation of cellular component size
EFV83_RS09880	COG1595	DNA-templated transcription, initiation
EFV83_RS09890	COG0783	Belongs to the Dps family
EFV83_RS09940	COG1252	NADH dehydrogenase
EFV83_RS09960	COG1937	Protein conserved in bacteria
EFV83_RS09985	COG1403	HNH endonuclease
EFV83_RS10060	COG2140	Oxalate decarboxylase
EFV83_RS10085	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
EFV83_RS10105	COG1376	ErfK ybiS ycfS ynhG family protein
EFV83_RS10130	COG2030	dehydratase
EFV83_RS10135	COG0488	(ABC) transporter
EFV83_RS10140	COG3757	hydrolase, family 25
EFV83_RS10205	COG0583	DNA-binding transcription factor activity
EFV83_RS10215	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EFV83_RS10230	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EFV83_RS10235	COG3757	hydrolase, family 25
EFV83_RS10455	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EFV83_RS10485	COG0745	RESPONSE REGULATOR receiver
EFV83_RS10490	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EFV83_RS10550	COG0640	Transcriptional regulator
EFV83_RS10555	COG0640	Transcriptional regulator
EFV83_RS10560	COG0798	PFAM Bile acid sodium symporter
EFV83_RS10565	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EFV83_RS10570	COG0446	pyridine nucleotide-disulphide oxidoreductase
EFV83_RS10580	COG0717	Belongs to the dCTP deaminase family
EFV83_RS10620	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
EFV83_RS10645	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
EFV83_RS10655	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EFV83_RS10690	COG0454	-acetyltransferase
EFV83_RS10735	COG0629	single-stranded DNA binding
EFV83_RS10750	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EFV83_RS10780	COG1260	myo-inositol-1-phosphate synthase
EFV83_RS10790	COG1113	amino acid transport
EFV83_RS10805	COG1309	transcriptional regulator
EFV83_RS10810	COG1028	Short-chain dehydrogenase reductase Sdr
EFV83_RS10825	COG0508	dehydrogenase complex catalyzes the overall conversion of
EFV83_RS10830	COG0022	dehydrogenase e1 component
EFV83_RS10845	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
EFV83_RS10850	COG2311	Membrane
EFV83_RS10920	COG0617	tRNA 3'-terminal CCA addition
EFV83_RS10940	COG1595	DNA-templated transcription, initiation
EFV83_RS10960	COG0860	N-Acetylmuramoyl-L-alanine amidase
EFV83_RS10960	COG3409	Peptidoglycan-binding domain 1 protein
EFV83_RS10970	COG2124	cytochrome p450
EFV83_RS10980	COG1309	transcriptional regulator
EFV83_RS11000	COG1192	Involved in chromosome partitioning
EFV83_RS11005	COG0357	Ribosomal RNA small subunit methyltransferase G
EFV83_RS11015	COG0706	membrane insertase activity
EFV83_RS11020	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
EFV83_RS11050	COG0592	DNA-directed DNA polymerase activity
EFV83_RS11055	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
EFV83_RS11060	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EFV83_RS11065	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
EFV83_RS11070	COG0187	DNA topoisomerase II activity
EFV83_RS11155	COG2814	Major facilitator Superfamily
EFV83_RS11160	COG0583	DNA-binding transcription factor activity
EFV83_RS11175	COG0457	Tetratricopeptide repeat
EFV83_RS11175	COG0705	Rhomboid family
EFV83_RS11210	COG0515	serine threonine protein kinase
EFV83_RS11210	COG2815	serine threonine protein kinase
EFV83_RS11215	COG0515	serine threonine protein kinase
EFV83_RS11220	COG0768	penicillin binding
EFV83_RS11235	COG1716	ATPase activity
EFV83_RS11240	COG1716	ATPase activity
EFV83_RS11255	COG0754	glutathionylspermidine amidase activity
EFV83_RS11265	COG1309	transcriptional regulator
EFV83_RS11285	COG4842	Belongs to the WXG100 family
EFV83_RS11305	COG0590	tRNA wobble adenosine to inosine editing
EFV83_RS11315	COG0583	DNA-binding transcription factor activity
EFV83_RS11320	COG1643	Atp-dependent helicase
EFV83_RS11325	COG1028	Short-chain dehydrogenase reductase Sdr
EFV83_RS11350	COG4585	Histidine kinase
EFV83_RS11370	COG1960	acyl-CoA dehydrogenase activity
EFV83_RS11415	COG2072	flavoprotein involved in K transport
EFV83_RS11425	COG0346	lactoylglutathione lyase activity
EFV83_RS11430	COG1414	Transcriptional regulator
EFV83_RS11450	COG1053	succinate dehydrogenase
EFV83_RS11480	COG1785	Belongs to the alkaline phosphatase family
EFV83_RS11500	COG0069	glutamate synthase activity
EFV83_RS11500	COG0067	glutamate synthase
EFV83_RS11500	COG0070	glutamate synthase
EFV83_RS11530	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
EFV83_RS11530	COG1796	DNA polymerase
EFV83_RS11540	COG2072	flavoprotein involved in K transport
EFV83_RS11550	COG2124	cytochrome p450
EFV83_RS11565	COG1024	Enoyl-CoA hydratase
EFV83_RS11595	COG2372	response to copper ion
EFV83_RS11650	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EFV83_RS11670	COG5002	protein histidine kinase activity
EFV83_RS11670	COG5001	Diguanylate cyclase
EFV83_RS11670	COG3447	MASE1 domain protein
EFV83_RS11680	COG1528	Iron-storage protein
EFV83_RS11685	COG1528	Iron-storage protein
EFV83_RS11690	COG1316	TRANSCRIPTIONal
EFV83_RS11715	COG0406	alpha-ribazole phosphatase activity
EFV83_RS11725	COG0028	Belongs to the TPP enzyme family
EFV83_RS11755	COG2072	flavoprotein involved in K transport
EFV83_RS11765	COG2072	flavoprotein involved in K transport
EFV83_RS11785	COG1285	pathogenesis
EFV83_RS11835	COG2146	nitrite reductase [NAD(P)H] activity
EFV83_RS11835	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
EFV83_RS11845	COG4133	protoheme IX ABC transporter activity
EFV83_RS11850	COG2070	2-Nitropropane dioxygenase
EFV83_RS11855	COG1942	4-Oxalocrotonate Tautomerase
EFV83_RS11860	COG0583	DNA-binding transcription factor activity
EFV83_RS11875	COG1028	Short-chain dehydrogenase reductase Sdr
EFV83_RS11890	COG0561	phosphatase activity
EFV83_RS11910	COG1216	Glycosyl transferase, family 2
EFV83_RS11915	COG0671	phosphoesterase, PA-phosphatase related
EFV83_RS11920	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
EFV83_RS11925	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
EFV83_RS11945	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
EFV83_RS11950	COG0318	PFAM AMP-dependent synthetase and ligase
EFV83_RS11955	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EFV83_RS11955	COG3321	synthase
EFV83_RS11955	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
EFV83_RS11960	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EFV83_RS12010	COG1028	Short-chain dehydrogenase reductase Sdr
EFV83_RS12015	COG0277	FAD linked oxidase domain protein
EFV83_RS12025	COG2376	Dihydroxyacetone kinase
EFV83_RS12030	COG2267	carboxylic ester hydrolase activity
EFV83_RS12035	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EFV83_RS12040	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EFV83_RS12055	COG0671	phosphoesterase, PA-phosphatase related
EFV83_RS12065	COG1216	Glycosyl transferase, family 2
EFV83_RS12150	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EFV83_RS12155	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EFV83_RS12275	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EFV83_RS12350	COG1960	acyl-CoA dehydrogenase activity
EFV83_RS12370	COG1028	Short-chain dehydrogenase reductase Sdr
EFV83_RS12390	COG1174	glycine betaine transport
EFV83_RS12405	COG0287	Prephenate dehydrogenase
EFV83_RS12415	COG0590	tRNA wobble adenosine to inosine editing
EFV83_RS12455	COG0343	queuine tRNA-ribosyltransferase activity
EFV83_RS12465	COG0765	amino acid transport
EFV83_RS12470	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EFV83_RS12475	COG1793	dna ligase
EFV83_RS12505	COG2271	Major facilitator Superfamily
EFV83_RS12510	COG2130	NADP-dependent
EFV83_RS12535	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
EFV83_RS12560	COG1028	Short-chain dehydrogenase reductase Sdr
EFV83_RS12610	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EFV83_RS12635	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EFV83_RS12645	COG0148	phosphopyruvate hydratase activity
EFV83_RS12675	COG0860	N-Acetylmuramoyl-L-alanine amidase
EFV83_RS12700	COG1492	cobalamin metabolic process
EFV83_RS12725	COG1960	acyl-CoA dehydrogenase activity
EFV83_RS12740	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
EFV83_RS12770	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EFV83_RS12795	COG1231	oxidoreductase activity
EFV83_RS12825	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EFV83_RS12835	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EFV83_RS12865	COG2070	2-Nitropropane dioxygenase
EFV83_RS12910	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EFV83_RS12915	COG2971	BadF BadG BcrA BcrD
EFV83_RS12920	COG2814	Major facilitator Superfamily
EFV83_RS12940	COG3572	ergothioneine biosynthetic process
EFV83_RS12945	COG1262	PFAM Formylglycine-generating sulfatase enzyme
EFV83_RS12950	COG0121	glutamine amidotransferase
EFV83_RS12955	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
EFV83_RS12960	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EFV83_RS12985	COG0183	Belongs to the thiolase family
EFV83_RS12990	COG2030	dehydratase
EFV83_RS12995	COG1028	Short-chain dehydrogenase reductase Sdr
EFV83_RS13000	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
EFV83_RS13010	COG1695	Transcriptional regulator
EFV83_RS13020	COG0475	glutathione-regulated potassium exporter activity
EFV83_RS13020	COG0569	domain protein
EFV83_RS13040	COG0714	Associated with various cellular activities
EFV83_RS13085	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EFV83_RS13090	COG1074	ATP-dependent DNA helicase activity
EFV83_RS13095	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
EFV83_RS13105	COG2755	lipolytic protein G-D-S-L family
EFV83_RS13130	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EFV83_RS13135	COG1408	metallophosphoesterase
EFV83_RS13140	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
EFV83_RS13170	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EFV83_RS13210	COG2945	thiolester hydrolase activity
EFV83_RS13210	COG0596	Alpha beta hydrolase
EFV83_RS13225	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EFV83_RS13230	COG0747	negative chemotaxis
EFV83_RS13240	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EFV83_RS13320	COG0582	viral genome integration into host DNA
EFV83_RS13370	COG2217	Heavy metal translocating P-type atpase
EFV83_RS13380	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EFV83_RS13440	COG2132	Multicopper oxidase
EFV83_RS13475	COG0596	Alpha beta hydrolase
EFV83_RS13535	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EFV83_RS13540	COG1309	transcriptional regulator
EFV83_RS13545	COG0657	acetylesterase activity
EFV83_RS13550	COG1902	pentaerythritol trinitrate reductase activity
EFV83_RS13555	COG1111	helicase
EFV83_RS13555	COG1205	dead DEAH box helicase
EFV83_RS13560	COG1278	Cold shock
EFV83_RS13570	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EFV83_RS13570	COG1754	DNA topoisomerase type I activity
EFV83_RS13580	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
EFV83_RS13690	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EFV83_RS13725	COG2027	D-alanyl-D-alanine carboxypeptidase
EFV83_RS13760	COG1063	alcohol dehydrogenase
EFV83_RS13770	COG2267	carboxylic ester hydrolase activity
EFV83_RS13780	COG1309	transcriptional regulator
EFV83_RS13795	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EFV83_RS13840	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
EFV83_RS13850	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
EFV83_RS13870	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
EFV83_RS13875	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EFV83_RS13915	COG4977	sequence-specific DNA binding
EFV83_RS13920	COG1194	a g-specific adenine glycosylase
EFV83_RS13930	COG1316	TRANSCRIPTIONal
EFV83_RS13940	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
EFV83_RS13950	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
EFV83_RS13970	COG1329	Transcriptional regulator
EFV83_RS13975	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
EFV83_RS13985	COG0215	cysteine-tRNA ligase activity
EFV83_RS13995	COG0584	glycerophosphoryl diester phosphodiesterase
EFV83_RS14005	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EFV83_RS14010	COG1120	ATPase activity
EFV83_RS14015	COG0803	Belongs to the bacterial solute-binding protein 9 family
EFV83_RS14025	COG1309	transcriptional regulator
EFV83_RS14030	COG1960	acyl-CoA dehydrogenase activity
EFV83_RS14045	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EFV83_RS14055	COG0346	lactoylglutathione lyase activity
EFV83_RS14095	COG1960	acyl-CoA dehydrogenase activity
EFV83_RS14100	COG1960	acyl-CoA dehydrogenase activity
EFV83_RS14105	COG1960	acyl-CoA dehydrogenase activity
EFV83_RS14110	COG0318	PFAM AMP-dependent synthetase and ligase
EFV83_RS14115	COG1960	acyl-CoA dehydrogenase activity
EFV83_RS14130	COG0183	Belongs to the thiolase family
EFV83_RS14160	COG1024	Enoyl-CoA hydratase
EFV83_RS14165	COG1028	Short-chain dehydrogenase reductase Sdr
EFV83_RS14170	COG1028	Short-chain dehydrogenase reductase Sdr
EFV83_RS14190	COG0183	Belongs to the thiolase family
EFV83_RS14200	COG1960	acyl-CoA dehydrogenase activity
EFV83_RS14205	COG1960	acyl-CoA dehydrogenase activity
EFV83_RS14210	COG2030	dehydratase
EFV83_RS14235	COG2030	dehydratase
EFV83_RS14240	COG1053	succinate dehydrogenase
EFV83_RS14250	COG3971	2-oxopent-4-enoate hydratase activity
EFV83_RS14300	COG0651	ATP synthesis coupled electron transport
EFV83_RS14310	COG2111	Na H antiporter
EFV83_RS14310	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EFV83_RS14315	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EFV83_RS14335	COG0647	UMP catabolic process
EFV83_RS14360	COG4221	oxidoreductase activity
EFV83_RS14380	COG0459	protein refolding
EFV83_RS14395	COG0714	Associated with various cellular activities
EFV83_RS14445	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EFV83_RS14460	COG4842	Belongs to the WXG100 family
EFV83_RS14505	COG0745	RESPONSE REGULATOR receiver
EFV83_RS14510	COG5002	protein histidine kinase activity
EFV83_RS14510	COG5000	phosphorelay sensor kinase activity
EFV83_RS14515	COG0537	adenosine 5'-monophosphoramidase activity
EFV83_RS14520	COG0697	spore germination
EFV83_RS14530	COG0596	Alpha beta hydrolase
EFV83_RS14560	COG0436	Aminotransferase
EFV83_RS14570	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
EFV83_RS14595	COG0477	Major facilitator Superfamily
EFV83_RS14600	COG0386	Belongs to the glutathione peroxidase family
EFV83_RS14610	COG3573	Dehydrogenase
EFV83_RS14620	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EFV83_RS14635	COG2837	iron assimilation
EFV83_RS14640	COG1362	aminopeptidase activity
EFV83_RS14720	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EFV83_RS14730	COG0601	transmembrane transport
EFV83_RS14735	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EFV83_RS14740	COG4172	Belongs to the ABC transporter superfamily
EFV83_RS14770	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
EFV83_RS14780	COG0354	folic acid binding
EFV83_RS14835	COG2897	thiosulfate sulfurtransferase activity
EFV83_RS14855	COG0745	RESPONSE REGULATOR receiver
EFV83_RS14875	COG0581	inorganic phosphate transmembrane transporter activity
EFV83_RS14880	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EFV83_RS14885	COG0604	alcohol dehydrogenase
EFV83_RS14940	COG1250	3-hydroxyacyl-CoA dehydrogenase
EFV83_RS14965	COG0697	spore germination
EFV83_RS14985	COG0442	prolyl-tRNA aminoacylation
EFV83_RS14990	COG2814	Major facilitator Superfamily
EFV83_RS15200	COG5651	PPE family
EFV83_RS15205	COG0436	Aminotransferase
EFV83_RS15225	COG0531	amino acid
EFV83_RS15230	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
EFV83_RS15235	COG1012	belongs to the aldehyde dehydrogenase family
EFV83_RS15245	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EFV83_RS15250	COG2902	Dehydrogenase
EFV83_RS15255	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EFV83_RS15260	COG1960	acyl-CoA dehydrogenase activity
EFV83_RS15265	COG1012	belongs to the aldehyde dehydrogenase family
EFV83_RS15270	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EFV83_RS15280	COG0657	acetylesterase activity
EFV83_RS15285	COG1028	Short-chain dehydrogenase reductase Sdr
EFV83_RS15300	COG1902	pentaerythritol trinitrate reductase activity
EFV83_RS15305	COG1902	pentaerythritol trinitrate reductase activity
EFV83_RS15320	COG1028	Short-chain dehydrogenase reductase Sdr
EFV83_RS15335	COG1024	Enoyl-CoA hydratase
EFV83_RS15380	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EFV83_RS15385	COG0657	acetylesterase activity
EFV83_RS15405	COG0183	Belongs to the thiolase family
EFV83_RS15420	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EFV83_RS15440	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EFV83_RS15455	COG1061	Type III restriction enzyme res subunit
EFV83_RS15495	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EFV83_RS15520	COG1278	Cold shock
EFV83_RS15560	COG2814	Major facilitator Superfamily
EFV83_RS15625	COG3185	4-Hydroxyphenylpyruvate dioxygenase
EFV83_RS15630	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EFV83_RS15660	COG2030	dehydratase
EFV83_RS15660	COG1012	belongs to the aldehyde dehydrogenase family
EFV83_RS15665	COG1309	transcriptional regulator
EFV83_RS15675	COG1024	Enoyl-CoA hydratase
EFV83_RS15680	COG1250	3-hydroxyacyl-CoA dehydrogenase
EFV83_RS15690	COG3396	Phenylacetate-CoA oxygenase
EFV83_RS15695	COG3460	Phenylacetate-CoA oxygenase
EFV83_RS15700	COG3396	Phenylacetate-CoA oxygenase
EFV83_RS15705	COG2151	metal-sulfur cluster biosynthetic enzyme
EFV83_RS15710	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EFV83_RS15735	COG0179	Fumarylacetoacetate (FAA) hydrolase
EFV83_RS15745	COG2124	cytochrome p450
EFV83_RS15775	COG1764	response to oxidative stress
EFV83_RS15780	COG1846	Transcriptional regulator
EFV83_RS15785	COG1216	Glycosyl transferase, family 2
EFV83_RS15790	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
EFV83_RS15820	COG0259	pyridoxamine-phosphate oxidase activity
EFV83_RS15830	COG0318	PFAM AMP-dependent synthetase and ligase
EFV83_RS15835	COG5651	PPE family
EFV83_RS15840	COG2409	Drug exporters of the RND superfamily
EFV83_RS15865	COG4977	sequence-specific DNA binding
EFV83_RS15885	COG1846	Transcriptional regulator
EFV83_RS15890	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EFV83_RS15900	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EFV83_RS15905	COG0833	amino acid
EFV83_RS15920	COG2186	Transcriptional regulator
EFV83_RS15925	COG0545	Peptidyl-prolyl cis-trans isomerase
EFV83_RS15965	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
EFV83_RS15970	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
EFV83_RS16015	COG1012	belongs to the aldehyde dehydrogenase family
EFV83_RS16030	COG3022	response to hydroperoxide
EFV83_RS16040	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EFV83_RS16075	COG1309	transcriptional regulator
EFV83_RS16110	COG1393	Belongs to the ArsC family
EFV83_RS16115	COG0583	DNA-binding transcription factor activity
EFV83_RS16155	COG0183	Belongs to the thiolase family
EFV83_RS16200	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EFV83_RS16240	COG0438	transferase activity, transferring glycosyl groups
EFV83_RS16250	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EFV83_RS16265	COG2382	esterase
EFV83_RS16295	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
EFV83_RS16300	COG1846	Transcriptional regulator
EFV83_RS16350	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
EFV83_RS16360	COG2326	polyphosphate kinase activity
EFV83_RS16375	COG2084	Dehydrogenase
EFV83_RS16390	COG0523	cobalamin synthesis protein
EFV83_RS16395	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EFV83_RS16400	COG0235	Class ii aldolase
EFV83_RS16405	COG1396	sequence-specific DNA binding
EFV83_RS16410	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EFV83_RS16415	COG0166	Belongs to the GPI family
EFV83_RS16530	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EFV83_RS16560	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EFV83_RS16565	COG0315	cyclic pyranopterin monophosphate synthase activity
EFV83_RS16565	COG0521	Mo-molybdopterin cofactor biosynthetic process
EFV83_RS16600	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
EFV83_RS16605	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EFV83_RS16640	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EFV83_RS16645	COG1104	cysteine desulfurase activity
EFV83_RS16795	COG2235	arginine
EFV83_RS16810	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EFV83_RS16825	COG1252	NADH dehydrogenase
EFV83_RS16835	COG0084	hydrolase, TatD family'
EFV83_RS16840	COG3583	domain protein
EFV83_RS16855	COG2815	serine threonine protein kinase
EFV83_RS16855	COG0515	serine threonine protein kinase
EFV83_RS16875	COG2409	Drug exporters of the RND superfamily
EFV83_RS16880	COG0456	acetyltransferase
EFV83_RS16880	COG1846	Transcriptional regulator
EFV83_RS16885	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
EFV83_RS16890	COG0318	PFAM AMP-dependent synthetase and ligase
EFV83_RS16905	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
EFV83_RS16940	COG1309	transcriptional regulator
EFV83_RS16985	COG3956	TIGRFAM MazG family protein
EFV83_RS17000	COG2837	iron assimilation
EFV83_RS17005	COG2822	iron ion transport
EFV83_RS17040	COG0596	Alpha beta hydrolase
EFV83_RS17065	COG0318	PFAM AMP-dependent synthetase and ligase
EFV83_RS17075	COG0427	acetyl-CoA hydrolase
EFV83_RS17120	COG1846	Transcriptional regulator
EFV83_RS17135	COG1024	Enoyl-CoA hydratase
EFV83_RS17160	COG0183	Belongs to the thiolase family
EFV83_RS17165	COG2755	lipolytic protein G-D-S-L family
EFV83_RS17170	COG0657	acetylesterase activity
EFV83_RS17180	COG1714	RDD family
EFV83_RS17195	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EFV83_RS17215	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EFV83_RS17225	COG1331	Highly conserved protein containing a thioredoxin domain
EFV83_RS17230	COG3631	Ketosteroid isomerase-related protein
EFV83_RS17245	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
EFV83_RS17250	COG1028	Short-chain dehydrogenase reductase Sdr
EFV83_RS17255	COG2124	cytochrome p450
EFV83_RS17275	COG1028	Short-chain dehydrogenase reductase Sdr
EFV83_RS17315	COG2272	Belongs to the type-B carboxylesterase lipase family
EFV83_RS17325	COG1174	glycine betaine transport
EFV83_RS17335	COG1174	glycine betaine transport
EFV83_RS17380	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EFV83_RS17395	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
EFV83_RS17400	COG0726	polysaccharide deacetylase
EFV83_RS17475	COG1570	exodeoxyribonuclease VII activity
EFV83_RS17485	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
EFV83_RS17500	COG1966	Carbon starvation protein
EFV83_RS17525	COG3189	MarR family transcriptional regulator
EFV83_RS17530	COG0012	GTP binding
EFV83_RS17555	COG2132	Multicopper oxidase
EFV83_RS17565	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EFV83_RS17575	COG0488	(ABC) transporter
EFV83_RS17630	COG2409	Drug exporters of the RND superfamily
EFV83_RS17665	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EFV83_RS17685	COG1716	ATPase activity
EFV83_RS17715	COG1051	belongs to the nudix hydrolase family
EFV83_RS17745	COG1217	gtp-binding protein TYPA
EFV83_RS17755	COG2015	COG2015, Alkyl sulfatase and related hydrolases
EFV83_RS17760	COG2207	Transcriptional regulator
EFV83_RS17760	COG1609	Transcriptional regulator
EFV83_RS17825	COG0446	pyridine nucleotide-disulphide oxidoreductase
EFV83_RS17825	COG1902	pentaerythritol trinitrate reductase activity
EFV83_RS17835	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
EFV83_RS17845	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
EFV83_RS17850	COG1012	belongs to the aldehyde dehydrogenase family
EFV83_RS17855	COG0506	proline dehydrogenase activity
EFV83_RS17860	COG0318	PFAM AMP-dependent synthetase and ligase
EFV83_RS17885	COG2207	Transcriptional regulator
EFV83_RS17900	COG1611	Belongs to the LOG family
EFV83_RS17905	COG1611	Belongs to the LOG family
EFV83_RS17910	COG0318	PFAM AMP-dependent synthetase and ligase
EFV83_RS17920	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EFV83_RS17930	COG0463	Glycosyl transferase, family 2
EFV83_RS17945	COG0519	Catalyzes the synthesis of GMP from XMP
EFV83_RS17955	COG0297	glycogen (starch) synthase activity
EFV83_RS17980	COG3559	Exporter of polyketide antibiotics
EFV83_RS17985	COG1131	(ABC) transporter
EFV83_RS17990	COG1309	transcriptional regulator
EFV83_RS18000	COG1595	DNA-templated transcription, initiation
EFV83_RS18005	COG5662	AntiSigma factor
EFV83_RS18010	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EFV83_RS18080	COG0598	Magnesium transport protein CorA
EFV83_RS18090	COG1309	transcriptional regulator
EFV83_RS18110	COG2095	MarC family integral membrane protein
EFV83_RS18125	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EFV83_RS18130	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EFV83_RS18150	COG3835	regulator
EFV83_RS18155	COG1073	alpha beta
EFV83_RS18160	COG0508	dehydrogenase complex catalyzes the overall conversion of
EFV83_RS18160	COG0567	Dehydrogenase, E1 component
EFV83_RS18170	COG2814	Major facilitator Superfamily
EFV83_RS18230	COG0277	FAD linked oxidase domain protein
EFV83_RS18235	COG1028	Short-chain dehydrogenase reductase Sdr
EFV83_RS18250	COG0668	transmembrane transport
EFV83_RS18340	COG2814	Major facilitator Superfamily
EFV83_RS18370	COG0019	diaminopimelate decarboxylase activity
EFV83_RS18375	COG0460	homoserine dehydrogenase
EFV83_RS18380	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
EFV83_RS18420	COG2890	protein-(glutamine-N5) methyltransferase activity
EFV83_RS18430	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EFV83_RS18440	COG0356	it plays a direct role in the translocation of protons across the membrane
EFV83_RS18445	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EFV83_RS18470	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
EFV83_RS18530	COG0346	lactoylglutathione lyase activity
EFV83_RS18535	COG0183	Belongs to the thiolase family
EFV83_RS18540	COG2409	Drug exporters of the RND superfamily
EFV83_RS18555	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
EFV83_RS18560	COG0366	Alpha amylase catalytic
EFV83_RS18565	COG0058	SHG alpha-glucan phosphorylase activity
EFV83_RS18580	COG1335	isochorismatase
EFV83_RS18590	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
EFV83_RS18605	COG3191	aminopeptidase activity
EFV83_RS18650	COG0604	alcohol dehydrogenase
EFV83_RS18670	COG0318	PFAM AMP-dependent synthetase and ligase
EFV83_RS18685	COG0419	ATPase involved in DNA repair
EFV83_RS18690	COG1024	Enoyl-CoA hydratase
EFV83_RS18700	COG0243	molybdopterin cofactor binding
EFV83_RS18715	COG2188	Transcriptional regulator
EFV83_RS18775	COG0596	Alpha beta hydrolase
EFV83_RS18780	COG3757	hydrolase, family 25
EFV83_RS18800	COG1051	belongs to the nudix hydrolase family
EFV83_RS18820	COG1309	transcriptional regulator
EFV83_RS18835	COG4585	Histidine kinase
EFV83_RS18840	COG2197	response regulator
EFV83_RS18850	COG2239	Acts as a magnesium transporter
EFV83_RS18860	COG0300	oxidoreductase activity
EFV83_RS18870	COG0656	L-ascorbic acid biosynthetic process
EFV83_RS18885	COG1376	ErfK ybiS ycfS ynhG family protein
EFV83_RS18900	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
EFV83_RS18905	COG0433	COG0433 Predicted ATPase
EFV83_RS18920	COG0300	oxidoreductase activity
EFV83_RS18935	COG1301	dicarboxylic acid transport
EFV83_RS18945	COG0531	amino acid
EFV83_RS18965	COG4424	Sulfotransferase
EFV83_RS18970	COG3119	arylsulfatase activity
EFV83_RS19005	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EFV83_RS19005	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EFV83_RS19045	COG2902	Dehydrogenase
EFV83_RS19050	COG0824	Thioesterase
EFV83_RS19065	COG0366	Alpha amylase catalytic
EFV83_RS19100	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
EFV83_RS19120	COG1309	transcriptional regulator
EFV83_RS19135	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
EFV83_RS19155	COG0740	serine-type endopeptidase activity
EFV83_RS19160	COG0740	serine-type endopeptidase activity
EFV83_RS19210	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
EFV83_RS19220	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
EFV83_RS19220	COG0674	pyruvate-flavodoxin oxidoreductase activity
EFV83_RS19225	COG1013	pyruvate-flavodoxin oxidoreductase activity
EFV83_RS19235	COG1388	LysM domain
EFV83_RS19265	COG0525	valine-tRNA ligase activity
EFV83_RS19270	COG0285	dihydrofolate synthase activity
EFV83_RS19285	COG1530	ribonuclease E activity
EFV83_RS19315	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
EFV83_RS19335	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EFV83_RS19340	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
EFV83_RS19345	COG0542	response to heat
EFV83_RS19355	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
EFV83_RS19365	COG0406	alpha-ribazole phosphatase activity
EFV83_RS19370	COG2755	lipolytic protein G-D-S-L family
EFV83_RS19390	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EFV83_RS19425	COG2308	Evidence 4 Homologs of previously reported genes of
EFV83_RS19435	COG1305	Transglutaminase-like
EFV83_RS19465	COG3387	PFAM Glycoside hydrolase 15-related
EFV83_RS19480	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EFV83_RS19515	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
EFV83_RS19520	COG4208	sulfate ABC transporter
EFV83_RS19580	COG0484	heat shock protein binding
EFV83_RS19665	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EFV83_RS19680	COG0076	glutamate decarboxylase activity
EFV83_RS19715	COG0318	PFAM AMP-dependent synthetase and ligase
EFV83_RS19765	COG0423	glycine-tRNA ligase activity
EFV83_RS19770	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EFV83_RS19775	COG2515	1-aminocyclopropane-1-carboxylate deaminase
EFV83_RS19795	COG0358	DNA primase activity
EFV83_RS19860	COG0745	RESPONSE REGULATOR receiver
EFV83_RS19865	COG5002	protein histidine kinase activity
EFV83_RS20310	COG3179	chitinase
EFV83_RS20525	COG0488	(ABC) transporter
EFV83_RS20550	COG1960	acyl-CoA dehydrogenase activity
EFV83_RS20555	COG1335	isochorismatase
EFV83_RS20565	COG0058	SHG alpha-glucan phosphorylase activity
EFV83_RS20605	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EFV83_RS20610	COG1960	acyl-CoA dehydrogenase activity
EFV83_RS20615	COG0183	Belongs to the thiolase family
EFV83_RS20635	COG1228	amidohydrolase
EFV83_RS20665	COG3321	synthase
EFV83_RS20665	COG1028	Short-chain dehydrogenase reductase Sdr
EFV83_RS20665	COG0604	alcohol dehydrogenase
EFV83_RS20685	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EFV83_RS20715	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
EFV83_RS20745	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EFV83_RS20790	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
EFV83_RS20795	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
EFV83_RS20855	COG0714	Associated with various cellular activities
EFV83_RS20880	COG0557	exoribonuclease II activity
EFV83_RS20890	COG0318	PFAM AMP-dependent synthetase and ligase
EFV83_RS20915	COG0174	glutamine synthetase
EFV83_RS20920	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
EFV83_RS20950	COG2205	protein histidine kinase activity
EFV83_RS20980	COG0174	glutamine synthetase
EFV83_RS20990	COG0477	Major facilitator Superfamily
EFV83_RS21000	COG3486	L-lysine 6-monooxygenase (NADPH) activity
EFV83_RS21020	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
EFV83_RS21025	COG0321	lipoyl(octanoyl) transferase activity
EFV83_RS21040	COG1872	DUF167
EFV83_RS21060	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EFV83_RS21070	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
EFV83_RS21075	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
EFV83_RS21105	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EFV83_RS21155	COG2010	Cytochrome c
EFV83_RS21160	COG1845	cytochrome c oxidase, subunit III
EFV83_RS21165	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EFV83_RS21200	COG2226	methyltransferase
EFV83_RS21225	COG0003	Pfam Anion-transporting ATPase
EFV83_RS21235	COG0204	Acyl-transferase
EFV83_RS21240	COG5650	phosphatidylinositol metabolic process
EFV83_RS21250	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
EFV83_RS21275	COG0142	geranyltranstransferase activity
EFV83_RS21315	COG0768	penicillin binding
EFV83_RS21335	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
EFV83_RS21345	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EFV83_RS21360	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EFV83_RS21385	COG0640	Transcriptional regulator
EFV83_RS21440	COG0154	amidase activity
EFV83_RS21450	COG2957	Belongs to the agmatine deiminase family
EFV83_RS21465	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EFV83_RS21475	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EFV83_RS21485	COG1028	Short-chain dehydrogenase reductase Sdr
EFV83_RS21515	COG2814	Major facilitator Superfamily
EFV83_RS21595	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EFV83_RS21600	COG2030	dehydratase
EFV83_RS21620	COG1024	Enoyl-CoA hydratase
EFV83_RS21635	COG1309	transcriptional regulator
EFV83_RS21660	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EFV83_RS21705	COG2072	flavoprotein involved in K transport
EFV83_RS21715	COG2072	flavoprotein involved in K transport
EFV83_RS21730	COG0318	PFAM AMP-dependent synthetase and ligase
EFV83_RS21735	COG1960	acyl-CoA dehydrogenase activity
EFV83_RS21755	COG1960	acyl-CoA dehydrogenase activity
EFV83_RS21785	COG3621	Patatin-like phospholipase
EFV83_RS21845	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EFV83_RS21875	COG1968	undecaprenyl-diphosphatase activity
EFV83_RS21910	COG1218	3'(2'),5'-bisphosphate nucleotidase
EFV83_RS21920	COG1028	Short-chain dehydrogenase reductase Sdr
EFV83_RS21945	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EFV83_RS21955	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
EFV83_RS21955	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EFV83_RS21970	COG2860	membrane
EFV83_RS21980	COG0646	methionine synthase
EFV83_RS21980	COG1410	methionine synthase
EFV83_RS21985	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EFV83_RS21995	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
EFV83_RS22030	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
EFV83_RS22035	COG1034	ATP synthesis coupled electron transport
EFV83_RS22040	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
EFV83_RS22045	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EFV83_RS22125	COG0513	Belongs to the DEAD box helicase family
EFV83_RS22160	COG0028	Belongs to the TPP enzyme family
EFV83_RS22175	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EFV83_RS22180	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
EFV83_RS22185	COG4122	O-methyltransferase activity
EFV83_RS22215	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EFV83_RS22220	COG4521	taurine ABC transporter
EFV83_RS22225	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
EFV83_RS22265	COG2378	regulation of single-species biofilm formation
EFV83_RS22270	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EFV83_RS22305	COG0300	oxidoreductase activity
EFV83_RS22360	COG1574	metal-dependent hydrolase with the TIM-barrel fold
EFV83_RS22370	COG0463	Glycosyl transferase, family 2
EFV83_RS22375	COG1028	Short-chain dehydrogenase reductase Sdr
EFV83_RS22400	COG0604	alcohol dehydrogenase
EFV83_RS22400	COG1028	Short-chain dehydrogenase reductase Sdr
EFV83_RS22400	COG3321	synthase
EFV83_RS22420	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EFV83_RS22430	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EFV83_RS22435	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EFV83_RS22455	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
EFV83_RS22465	COG1404	Belongs to the peptidase S8 family
EFV83_RS22480	COG4842	Belongs to the WXG100 family
EFV83_RS22510	COG0464	growth
EFV83_RS22530	COG0583	DNA-binding transcription factor activity
EFV83_RS22560	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
EFV83_RS22565	COG1169	isochorismate synthase
EFV83_RS22570	COG0789	Transcriptional regulator
EFV83_RS22575	COG1021	2,3-dihydroxybenzoate-AMP ligase
EFV83_RS22605	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
EFV83_RS22630	COG0300	oxidoreductase activity
EFV83_RS22630	COG3321	synthase
EFV83_RS22630	COG1028	Short-chain dehydrogenase reductase Sdr
EFV83_RS22630	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EFV83_RS22630	COG0318	PFAM AMP-dependent synthetase and ligase
EFV83_RS22645	COG1132	(ABC) transporter
EFV83_RS22650	COG1132	(ABC) transporter
EFV83_RS22650	COG2375	cellular response to nickel ion
EFV83_RS22655	COG0477	Major facilitator Superfamily
EFV83_RS22660	COG5285	phytanoyl-CoA dioxygenase
EFV83_RS22670	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EFV83_RS22675	COG0456	acetyltransferase
EFV83_RS22690	COG2837	iron assimilation
EFV83_RS22700	COG2186	Transcriptional regulator
EFV83_RS22705	COG2807	transmembrane transport
EFV83_RS22715	COG2409	Drug exporters of the RND superfamily
EFV83_RS22720	COG3629	intracellular signal transduction
EFV83_RS22725	COG1012	belongs to the aldehyde dehydrogenase family
EFV83_RS22765	COG0475	glutathione-regulated potassium exporter activity
EFV83_RS22835	COG0237	dephospho-CoA kinase activity
EFV83_RS22835	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EFV83_RS23020	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
EFV83_RS23025	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EFV83_RS23025	COG0072	phenylalanine-tRNA ligase activity
EFV83_RS23035	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
EFV83_RS23040	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EFV83_RS23045	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EFV83_RS23050	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
EFV83_RS23055	COG1438	arginine binding
EFV83_RS23060	COG0137	argininosuccinate synthase activity
EFV83_RS23100	COG2835	tetraacyldisaccharide 4'-kinase activity
EFV83_RS23105	COG1309	transcriptional regulator
EFV83_RS23110	COG2094	Belongs to the DNA glycosylase MPG family
EFV83_RS23135	COG0647	UMP catabolic process
EFV83_RS23150	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
EFV83_RS23170	COG0504	CTP synthase activity
EFV83_RS23175	COG0494	nUDIX hydrolase
EFV83_RS23195	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
EFV83_RS23210	COG1160	GTP binding
EFV83_RS23220	COG1403	HNH endonuclease
EFV83_RS23300	COG1053	succinate dehydrogenase
EFV83_RS23300	COG3976	FMN-binding domain protein
EFV83_RS23330	COG1960	acyl-CoA dehydrogenase activity
EFV83_RS23390	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EFV83_RS23390	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EFV83_RS23405	COG1253	flavin adenine dinucleotide binding
EFV83_RS23410	COG1253	flavin adenine dinucleotide binding
EFV83_RS23420	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
EFV83_RS23475	COG0832	Belongs to the urease beta subunit family
EFV83_RS23485	COG0830	nickel cation binding
EFV83_RS23500	COG1252	NADH dehydrogenase
EFV83_RS23510	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EFV83_RS23545	COG0243	molybdopterin cofactor binding
EFV83_RS23555	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
EFV83_RS23570	COG1546	Belongs to the CinA family
EFV83_RS23570	COG1058	Belongs to the CinA family
EFV83_RS23580	COG4977	sequence-specific DNA binding
EFV83_RS23585	COG1741	Belongs to the pirin family
EFV83_RS23605	COG1968	undecaprenyl-diphosphatase activity
EFV83_RS23610	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
EFV83_RS23635	COG0277	FAD linked oxidase domain protein
EFV83_RS23645	COG1309	transcriptional regulator
EFV83_RS23660	COG1116	anion transmembrane transporter activity
EFV83_RS23665	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EFV83_RS23670	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EFV83_RS23695	COG4290	ribonuclease
EFV83_RS23730	COG0791	NLP P60 protein
EFV83_RS23730	COG3883	PFAM NLP P60 protein
EFV83_RS23765	COG0477	Major facilitator Superfamily
EFV83_RS23785	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
EFV83_RS23790	COG0067	glutamate synthase
EFV83_RS23790	COG0069	glutamate synthase activity
EFV83_RS23790	COG0070	glutamate synthase
EFV83_RS23820	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
EFV83_RS23835	COG1960	acyl-CoA dehydrogenase activity
EFV83_RS23850	COG0443	Heat shock 70 kDa protein
EFV83_RS23855	COG0596	Alpha beta hydrolase
EFV83_RS23875	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EFV83_RS23885	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
EFV83_RS23910	COG2890	protein-(glutamine-N5) methyltransferase activity
EFV83_RS23980	COG1982	Orn Lys Arg decarboxylase major
EFV83_RS24045	COG0028	Belongs to the TPP enzyme family
EFV83_RS24055	COG0318	PFAM AMP-dependent synthetase and ligase
EFV83_RS24075	COG1309	transcriptional regulator
EFV83_RS24080	COG2957	Belongs to the agmatine deiminase family
EFV83_RS24085	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EFV83_RS24100	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EFV83_RS24150	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
EFV83_RS24165	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
EFV83_RS24185	COG0640	Transcriptional regulator
EFV83_RS24195	COG0798	PFAM Bile acid sodium symporter
EFV83_RS24200	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EFV83_RS24205	COG0390	transport system, permease component
EFV83_RS24230	COG0318	PFAM AMP-dependent synthetase and ligase
EFV83_RS24235	COG0179	Fumarylacetoacetate (FAA) hydrolase
EFV83_RS24270	COG0745	RESPONSE REGULATOR receiver
EFV83_RS24275	COG2205	protein histidine kinase activity
EFV83_RS24290	COG1917	Cupin 2, conserved barrel domain protein
EFV83_RS24295	COG3707	response regulator
EFV83_RS24335	COG3467	pyridoxamine 5'-phosphate
EFV83_RS24340	COG4308	Limonene-1,2-epoxide hydrolase catalytic domain
EFV83_RS24360	COG0640	Transcriptional regulator
EFV83_RS24380	COG1309	transcriptional regulator
EFV83_RS24385	COG2072	flavoprotein involved in K transport
EFV83_RS24395	COG0318	PFAM AMP-dependent synthetase and ligase
EFV83_RS24400	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EFV83_RS24405	COG0561	phosphatase activity
EFV83_RS24410	COG0673	inositol 2-dehydrogenase activity
EFV83_RS24415	COG0738	Major facilitator superfamily
EFV83_RS24420	COG1403	HNH endonuclease
EFV83_RS24505	COG1271	oxidase subunit
EFV83_RS24510	COG1294	oxidase, subunit
EFV83_RS24515	COG4988	ABC transporter
EFV83_RS24520	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
EFV83_RS24545	COG1946	Acyl-CoA thioesterase
EFV83_RS24590	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EFV83_RS24595	COG1846	Transcriptional regulator
EFV83_RS24625	COG2072	flavoprotein involved in K transport
EFV83_RS24630	COG0657	acetylesterase activity
EFV83_RS24685	COG0483	inositol monophosphate 1-phosphatase activity
EFV83_RS24695	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
EFV83_RS24700	COG0131	Imidazoleglycerol-phosphate dehydratase
EFV83_RS24705	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EFV83_RS24730	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
EFV83_RS24745	COG1309	transcriptional regulator
EFV83_RS24760	COG0583	DNA-binding transcription factor activity
EFV83_RS24765	COG0579	oxidoreductase
EFV83_RS24805	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
EFV83_RS24805	COG2755	lipolytic protein G-D-S-L family
EFV83_RS24860	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
EFV83_RS24880	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
EFV83_RS24885	COG2814	Major facilitator Superfamily
EFV83_RS24890	COG0583	DNA-binding transcription factor activity
EFV83_RS24940	COG2239	Acts as a magnesium transporter
EFV83_RS24965	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
EFV83_RS24975	COG2304	oxidoreductase activity
EFV83_RS24985	COG0714	Associated with various cellular activities
EFV83_RS24995	COG3883	PFAM NLP P60 protein
EFV83_RS24995	COG0791	NLP P60 protein
EFV83_RS25005	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
EFV83_RS25010	COG1309	transcriptional regulator
EFV83_RS25035	COG0488	(ABC) transporter
EFV83_RS25050	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EFV83_RS25065	COG0456	acetyltransferase
EFV83_RS25075	COG2151	metal-sulfur cluster biosynthetic enzyme
EFV83_RS25090	COG0396	ATPase activity
EFV83_RS25115	COG1131	(ABC) transporter
EFV83_RS25155	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
EFV83_RS25175	COG0583	DNA-binding transcription factor activity
EFV83_RS25180	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EFV83_RS25250	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EFV83_RS25310	COG0531	amino acid
EFV83_RS25365	COG2011	ABC-type metal ion transport system permease component
EFV83_RS25370	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
EFV83_RS25390	COG0477	Major facilitator Superfamily
EFV83_RS25425	COG0657	acetylesterase activity