locus-tag	class	description
I3U38_RS00015	COG0592	DNA-directed DNA polymerase activity
I3U38_RS00020	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
I3U38_RS00025	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I3U38_RS00030	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
I3U38_RS00035	COG0187	DNA topoisomerase II activity
I3U38_RS00120	COG2814	Major facilitator Superfamily
I3U38_RS00125	COG0583	DNA-binding transcription factor activity
I3U38_RS00140	COG0457	Tetratricopeptide repeat
I3U38_RS00140	COG0705	Rhomboid family
I3U38_RS00175	COG0515	serine threonine protein kinase
I3U38_RS00175	COG2815	serine threonine protein kinase
I3U38_RS00180	COG0515	serine threonine protein kinase
I3U38_RS00185	COG0768	penicillin binding
I3U38_RS00200	COG1716	ATPase activity
I3U38_RS00205	COG1716	ATPase activity
I3U38_RS00220	COG0754	glutathionylspermidine amidase activity
I3U38_RS00230	COG1309	transcriptional regulator
I3U38_RS00250	COG4842	Belongs to the WXG100 family
I3U38_RS00270	COG0590	tRNA wobble adenosine to inosine editing
I3U38_RS00280	COG0583	DNA-binding transcription factor activity
I3U38_RS00285	COG1643	Atp-dependent helicase
I3U38_RS00290	COG1028	Short-chain dehydrogenase reductase Sdr
I3U38_RS00310	COG4585	Histidine kinase
I3U38_RS00330	COG1960	acyl-CoA dehydrogenase activity
I3U38_RS00375	COG2072	flavoprotein involved in K transport
I3U38_RS00385	COG0346	lactoylglutathione lyase activity
I3U38_RS00390	COG1414	Transcriptional regulator
I3U38_RS00410	COG1053	succinate dehydrogenase
I3U38_RS00440	COG1785	Belongs to the alkaline phosphatase family
I3U38_RS00460	COG0070	glutamate synthase
I3U38_RS00460	COG0067	glutamate synthase
I3U38_RS00460	COG0069	glutamate synthase activity
I3U38_RS00490	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I3U38_RS00490	COG1796	DNA polymerase
I3U38_RS00500	COG2072	flavoprotein involved in K transport
I3U38_RS00510	COG2124	cytochrome p450
I3U38_RS00525	COG1024	Enoyl-CoA hydratase
I3U38_RS00555	COG2372	response to copper ion
I3U38_RS00605	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I3U38_RS00625	COG5001	Diguanylate cyclase
I3U38_RS00625	COG3447	MASE1 domain protein
I3U38_RS00625	COG5002	protein histidine kinase activity
I3U38_RS00635	COG1528	Iron-storage protein
I3U38_RS00640	COG1528	Iron-storage protein
I3U38_RS00645	COG1316	TRANSCRIPTIONal
I3U38_RS00670	COG0406	alpha-ribazole phosphatase activity
I3U38_RS00680	COG0028	Belongs to the TPP enzyme family
I3U38_RS00710	COG2072	flavoprotein involved in K transport
I3U38_RS00720	COG2072	flavoprotein involved in K transport
I3U38_RS00740	COG1285	pathogenesis
I3U38_RS00790	COG2146	nitrite reductase [NAD(P)H] activity
I3U38_RS00790	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I3U38_RS00800	COG4133	protoheme IX ABC transporter activity
I3U38_RS00805	COG2070	2-Nitropropane dioxygenase
I3U38_RS00810	COG1942	4-Oxalocrotonate Tautomerase
I3U38_RS00815	COG0583	DNA-binding transcription factor activity
I3U38_RS00830	COG1028	Short-chain dehydrogenase reductase Sdr
I3U38_RS00845	COG0561	phosphatase activity
I3U38_RS00865	COG1216	Glycosyl transferase, family 2
I3U38_RS00870	COG0671	phosphoesterase, PA-phosphatase related
I3U38_RS00875	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I3U38_RS00880	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I3U38_RS00900	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
I3U38_RS00905	COG0318	PFAM AMP-dependent synthetase and ligase
I3U38_RS00910	COG3321	synthase
I3U38_RS00910	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
I3U38_RS00910	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I3U38_RS00915	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I3U38_RS00965	COG1028	Short-chain dehydrogenase reductase Sdr
I3U38_RS00970	COG0277	FAD linked oxidase domain protein
I3U38_RS00980	COG2376	Dihydroxyacetone kinase
I3U38_RS00985	COG2267	carboxylic ester hydrolase activity
I3U38_RS00990	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I3U38_RS00995	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I3U38_RS01010	COG0671	phosphoesterase, PA-phosphatase related
I3U38_RS01020	COG1216	Glycosyl transferase, family 2
I3U38_RS01100	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I3U38_RS01105	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I3U38_RS01175	COG1960	acyl-CoA dehydrogenase activity
I3U38_RS01195	COG1028	Short-chain dehydrogenase reductase Sdr
I3U38_RS01215	COG1174	glycine betaine transport
I3U38_RS01230	COG0287	Prephenate dehydrogenase
I3U38_RS01240	COG0590	tRNA wobble adenosine to inosine editing
I3U38_RS01280	COG0343	queuine tRNA-ribosyltransferase activity
I3U38_RS01290	COG0765	amino acid transport
I3U38_RS01295	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I3U38_RS01300	COG1793	dna ligase
I3U38_RS01330	COG2271	Major facilitator Superfamily
I3U38_RS01335	COG2130	NADP-dependent
I3U38_RS01360	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I3U38_RS01385	COG1028	Short-chain dehydrogenase reductase Sdr
I3U38_RS01435	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I3U38_RS01460	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I3U38_RS01470	COG0148	phosphopyruvate hydratase activity
I3U38_RS01500	COG0860	N-Acetylmuramoyl-L-alanine amidase
I3U38_RS01525	COG1492	cobalamin metabolic process
I3U38_RS01550	COG1960	acyl-CoA dehydrogenase activity
I3U38_RS01565	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I3U38_RS01595	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I3U38_RS01615	COG1231	oxidoreductase activity
I3U38_RS01645	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I3U38_RS01655	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I3U38_RS01685	COG2070	2-Nitropropane dioxygenase
I3U38_RS01730	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I3U38_RS01735	COG2971	BadF BadG BcrA BcrD
I3U38_RS01740	COG2814	Major facilitator Superfamily
I3U38_RS01760	COG3572	ergothioneine biosynthetic process
I3U38_RS01765	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I3U38_RS01770	COG0121	glutamine amidotransferase
I3U38_RS01775	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
I3U38_RS01780	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I3U38_RS01805	COG0183	Belongs to the thiolase family
I3U38_RS01810	COG2030	dehydratase
I3U38_RS01815	COG1028	Short-chain dehydrogenase reductase Sdr
I3U38_RS01820	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I3U38_RS01830	COG1695	Transcriptional regulator
I3U38_RS01840	COG0569	domain protein
I3U38_RS01840	COG0475	glutathione-regulated potassium exporter activity
I3U38_RS01860	COG0714	Associated with various cellular activities
I3U38_RS01905	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I3U38_RS01910	COG1074	ATP-dependent DNA helicase activity
I3U38_RS01915	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I3U38_RS01925	COG2755	lipolytic protein G-D-S-L family
I3U38_RS01955	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I3U38_RS01960	COG1408	metallophosphoesterase
I3U38_RS01965	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I3U38_RS01995	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I3U38_RS02035	COG0596	Alpha beta hydrolase
I3U38_RS02035	COG2945	thiolester hydrolase activity
I3U38_RS02050	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I3U38_RS02055	COG0747	negative chemotaxis
I3U38_RS02065	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I3U38_RS02135	COG0582	viral genome integration into host DNA
I3U38_RS02180	COG2217	Heavy metal translocating P-type atpase
I3U38_RS02190	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I3U38_RS02250	COG2132	Multicopper oxidase
I3U38_RS02285	COG0596	Alpha beta hydrolase
I3U38_RS02345	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I3U38_RS02350	COG1309	transcriptional regulator
I3U38_RS02355	COG0657	acetylesterase activity
I3U38_RS02360	COG1902	pentaerythritol trinitrate reductase activity
I3U38_RS02365	COG1205	dead DEAH box helicase
I3U38_RS02365	COG1111	helicase
I3U38_RS02370	COG1278	Cold shock
I3U38_RS02380	COG1754	DNA topoisomerase type I activity
I3U38_RS02380	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I3U38_RS02390	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I3U38_RS02500	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I3U38_RS02535	COG2027	D-alanyl-D-alanine carboxypeptidase
I3U38_RS02570	COG1063	alcohol dehydrogenase
I3U38_RS02580	COG2267	carboxylic ester hydrolase activity
I3U38_RS02590	COG1309	transcriptional regulator
I3U38_RS02605	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I3U38_RS02650	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
I3U38_RS02660	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I3U38_RS02680	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
I3U38_RS02685	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I3U38_RS02725	COG4977	sequence-specific DNA binding
I3U38_RS02730	COG1194	a g-specific adenine glycosylase
I3U38_RS02740	COG1316	TRANSCRIPTIONal
I3U38_RS02750	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
I3U38_RS02760	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I3U38_RS02780	COG1329	Transcriptional regulator
I3U38_RS02785	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
I3U38_RS02795	COG0215	cysteine-tRNA ligase activity
I3U38_RS02805	COG0584	glycerophosphoryl diester phosphodiesterase
I3U38_RS02815	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I3U38_RS02820	COG1120	ATPase activity
I3U38_RS02825	COG0803	Belongs to the bacterial solute-binding protein 9 family
I3U38_RS02835	COG1309	transcriptional regulator
I3U38_RS02840	COG1960	acyl-CoA dehydrogenase activity
I3U38_RS02855	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I3U38_RS02865	COG0346	lactoylglutathione lyase activity
I3U38_RS02905	COG1960	acyl-CoA dehydrogenase activity
I3U38_RS02910	COG1960	acyl-CoA dehydrogenase activity
I3U38_RS02915	COG1960	acyl-CoA dehydrogenase activity
I3U38_RS02920	COG0318	PFAM AMP-dependent synthetase and ligase
I3U38_RS02925	COG1960	acyl-CoA dehydrogenase activity
I3U38_RS02940	COG0183	Belongs to the thiolase family
I3U38_RS02970	COG1024	Enoyl-CoA hydratase
I3U38_RS02975	COG1028	Short-chain dehydrogenase reductase Sdr
I3U38_RS02980	COG1028	Short-chain dehydrogenase reductase Sdr
I3U38_RS03000	COG0183	Belongs to the thiolase family
I3U38_RS03010	COG1960	acyl-CoA dehydrogenase activity
I3U38_RS03015	COG1960	acyl-CoA dehydrogenase activity
I3U38_RS03020	COG2030	dehydratase
I3U38_RS03045	COG2030	dehydratase
I3U38_RS03050	COG1053	succinate dehydrogenase
I3U38_RS03060	COG3971	2-oxopent-4-enoate hydratase activity
I3U38_RS03105	COG0651	ATP synthesis coupled electron transport
I3U38_RS03115	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I3U38_RS03115	COG2111	Na H antiporter
I3U38_RS03120	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I3U38_RS03140	COG0647	UMP catabolic process
I3U38_RS03165	COG4221	oxidoreductase activity
I3U38_RS03185	COG0459	protein refolding
I3U38_RS03200	COG0714	Associated with various cellular activities
I3U38_RS03250	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I3U38_RS03265	COG4842	Belongs to the WXG100 family
I3U38_RS03310	COG0745	RESPONSE REGULATOR receiver
I3U38_RS03315	COG5002	protein histidine kinase activity
I3U38_RS03315	COG5000	phosphorelay sensor kinase activity
I3U38_RS03320	COG0537	adenosine 5'-monophosphoramidase activity
I3U38_RS03325	COG0697	spore germination
I3U38_RS03335	COG0596	Alpha beta hydrolase
I3U38_RS03365	COG0436	Aminotransferase
I3U38_RS03375	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I3U38_RS03400	COG0477	Major facilitator Superfamily
I3U38_RS03405	COG0386	Belongs to the glutathione peroxidase family
I3U38_RS03415	COG3573	Dehydrogenase
I3U38_RS03425	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I3U38_RS03440	COG2837	iron assimilation
I3U38_RS03445	COG1362	aminopeptidase activity
I3U38_RS03525	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I3U38_RS03535	COG0601	transmembrane transport
I3U38_RS03540	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I3U38_RS03545	COG4172	Belongs to the ABC transporter superfamily
I3U38_RS03575	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I3U38_RS03585	COG0354	folic acid binding
I3U38_RS03635	COG2897	thiosulfate sulfurtransferase activity
I3U38_RS03655	COG0745	RESPONSE REGULATOR receiver
I3U38_RS03675	COG0581	inorganic phosphate transmembrane transporter activity
I3U38_RS03680	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I3U38_RS03685	COG0604	alcohol dehydrogenase
I3U38_RS03740	COG1250	3-hydroxyacyl-CoA dehydrogenase
I3U38_RS03765	COG0697	spore germination
I3U38_RS03785	COG0442	prolyl-tRNA aminoacylation
I3U38_RS03790	COG2814	Major facilitator Superfamily
I3U38_RS04000	COG5651	PPE family
I3U38_RS04005	COG0436	Aminotransferase
I3U38_RS04025	COG0531	amino acid
I3U38_RS04030	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
I3U38_RS04035	COG1012	belongs to the aldehyde dehydrogenase family
I3U38_RS04045	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I3U38_RS04050	COG2902	Dehydrogenase
I3U38_RS04055	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I3U38_RS04060	COG1960	acyl-CoA dehydrogenase activity
I3U38_RS04065	COG1012	belongs to the aldehyde dehydrogenase family
I3U38_RS04070	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I3U38_RS04080	COG0657	acetylesterase activity
I3U38_RS04085	COG1028	Short-chain dehydrogenase reductase Sdr
I3U38_RS04100	COG1902	pentaerythritol trinitrate reductase activity
I3U38_RS04105	COG1902	pentaerythritol trinitrate reductase activity
I3U38_RS04120	COG1028	Short-chain dehydrogenase reductase Sdr
I3U38_RS04135	COG1024	Enoyl-CoA hydratase
I3U38_RS04180	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I3U38_RS04185	COG0657	acetylesterase activity
I3U38_RS04205	COG0183	Belongs to the thiolase family
I3U38_RS04220	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I3U38_RS04240	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I3U38_RS04255	COG1061	Type III restriction enzyme res subunit
I3U38_RS04290	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I3U38_RS04315	COG1278	Cold shock
I3U38_RS04355	COG2814	Major facilitator Superfamily
I3U38_RS04425	COG3185	4-Hydroxyphenylpyruvate dioxygenase
I3U38_RS04430	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I3U38_RS04460	COG2030	dehydratase
I3U38_RS04460	COG1012	belongs to the aldehyde dehydrogenase family
I3U38_RS04465	COG1309	transcriptional regulator
I3U38_RS04475	COG1024	Enoyl-CoA hydratase
I3U38_RS04480	COG1250	3-hydroxyacyl-CoA dehydrogenase
I3U38_RS04490	COG3396	Phenylacetate-CoA oxygenase
I3U38_RS04495	COG3460	Phenylacetate-CoA oxygenase
I3U38_RS04500	COG3396	Phenylacetate-CoA oxygenase
I3U38_RS04505	COG2151	metal-sulfur cluster biosynthetic enzyme
I3U38_RS04510	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I3U38_RS04535	COG0179	Fumarylacetoacetate (FAA) hydrolase
I3U38_RS04545	COG2124	cytochrome p450
I3U38_RS04575	COG1764	response to oxidative stress
I3U38_RS04580	COG1846	Transcriptional regulator
I3U38_RS04585	COG1216	Glycosyl transferase, family 2
I3U38_RS04590	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I3U38_RS04620	COG0259	pyridoxamine-phosphate oxidase activity
I3U38_RS04630	COG0318	PFAM AMP-dependent synthetase and ligase
I3U38_RS04635	COG5651	PPE family
I3U38_RS04640	COG2409	Drug exporters of the RND superfamily
I3U38_RS04665	COG4977	sequence-specific DNA binding
I3U38_RS04690	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3U38_RS04700	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I3U38_RS04705	COG0833	amino acid
I3U38_RS04720	COG2186	Transcriptional regulator
I3U38_RS04725	COG0545	Peptidyl-prolyl cis-trans isomerase
I3U38_RS04765	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I3U38_RS04770	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
I3U38_RS04815	COG1012	belongs to the aldehyde dehydrogenase family
I3U38_RS04830	COG3022	response to hydroperoxide
I3U38_RS04840	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I3U38_RS04875	COG1309	transcriptional regulator
I3U38_RS04910	COG1393	Belongs to the ArsC family
I3U38_RS04955	COG0183	Belongs to the thiolase family
I3U38_RS05000	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I3U38_RS05040	COG0438	transferase activity, transferring glycosyl groups
I3U38_RS05045	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I3U38_RS05060	COG2382	esterase
I3U38_RS05090	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
I3U38_RS05095	COG1846	Transcriptional regulator
I3U38_RS05145	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I3U38_RS05155	COG2326	polyphosphate kinase activity
I3U38_RS05170	COG2084	Dehydrogenase
I3U38_RS05185	COG0523	cobalamin synthesis protein
I3U38_RS05190	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I3U38_RS05195	COG0235	Class ii aldolase
I3U38_RS05200	COG1396	sequence-specific DNA binding
I3U38_RS05205	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I3U38_RS05210	COG0166	Belongs to the GPI family
I3U38_RS05320	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I3U38_RS05350	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I3U38_RS05355	COG0521	Mo-molybdopterin cofactor biosynthetic process
I3U38_RS05355	COG0315	cyclic pyranopterin monophosphate synthase activity
I3U38_RS05390	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I3U38_RS05395	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I3U38_RS05430	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I3U38_RS05435	COG1104	cysteine desulfurase activity
I3U38_RS05580	COG2235	arginine
I3U38_RS05595	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I3U38_RS05610	COG1252	NADH dehydrogenase
I3U38_RS05620	COG0084	hydrolase, TatD family'
I3U38_RS05625	COG3583	domain protein
I3U38_RS05640	COG0515	serine threonine protein kinase
I3U38_RS05640	COG2815	serine threonine protein kinase
I3U38_RS05660	COG2409	Drug exporters of the RND superfamily
I3U38_RS05665	COG0456	acetyltransferase
I3U38_RS05665	COG1846	Transcriptional regulator
I3U38_RS05670	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I3U38_RS05675	COG0318	PFAM AMP-dependent synthetase and ligase
I3U38_RS05690	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I3U38_RS05725	COG1309	transcriptional regulator
I3U38_RS05770	COG3956	TIGRFAM MazG family protein
I3U38_RS05785	COG2837	iron assimilation
I3U38_RS05790	COG2822	iron ion transport
I3U38_RS05825	COG0596	Alpha beta hydrolase
I3U38_RS05850	COG0318	PFAM AMP-dependent synthetase and ligase
I3U38_RS05860	COG0427	acetyl-CoA hydrolase
I3U38_RS05910	COG1846	Transcriptional regulator
I3U38_RS05925	COG1024	Enoyl-CoA hydratase
I3U38_RS05950	COG0183	Belongs to the thiolase family
I3U38_RS05955	COG2755	lipolytic protein G-D-S-L family
I3U38_RS05960	COG0657	acetylesterase activity
I3U38_RS05970	COG1714	RDD family
I3U38_RS05985	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I3U38_RS06005	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I3U38_RS06015	COG1331	Highly conserved protein containing a thioredoxin domain
I3U38_RS06020	COG3631	Ketosteroid isomerase-related protein
I3U38_RS06035	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I3U38_RS06040	COG1028	Short-chain dehydrogenase reductase Sdr
I3U38_RS06045	COG2124	cytochrome p450
I3U38_RS06065	COG1028	Short-chain dehydrogenase reductase Sdr
I3U38_RS06105	COG2272	Belongs to the type-B carboxylesterase lipase family
I3U38_RS06115	COG1174	glycine betaine transport
I3U38_RS06125	COG1174	glycine betaine transport
I3U38_RS06170	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I3U38_RS06180	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
I3U38_RS06185	COG0726	polysaccharide deacetylase
I3U38_RS06255	COG1570	exodeoxyribonuclease VII activity
I3U38_RS06265	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I3U38_RS06280	COG1966	Carbon starvation protein
I3U38_RS06305	COG3189	MarR family transcriptional regulator
I3U38_RS06310	COG0012	GTP binding
I3U38_RS06335	COG2132	Multicopper oxidase
I3U38_RS06345	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I3U38_RS06355	COG0488	(ABC) transporter
I3U38_RS06410	COG2409	Drug exporters of the RND superfamily
I3U38_RS06445	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I3U38_RS06465	COG1716	ATPase activity
I3U38_RS06495	COG1051	belongs to the nudix hydrolase family
I3U38_RS06520	COG1217	gtp-binding protein TYPA
I3U38_RS06530	COG2015	COG2015, Alkyl sulfatase and related hydrolases
I3U38_RS06535	COG2207	Transcriptional regulator
I3U38_RS06535	COG1609	Transcriptional regulator
I3U38_RS06595	COG0446	pyridine nucleotide-disulphide oxidoreductase
I3U38_RS06595	COG1902	pentaerythritol trinitrate reductase activity
I3U38_RS06605	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
I3U38_RS06615	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I3U38_RS06620	COG1012	belongs to the aldehyde dehydrogenase family
I3U38_RS06625	COG0506	proline dehydrogenase activity
I3U38_RS06630	COG0318	PFAM AMP-dependent synthetase and ligase
I3U38_RS06655	COG2207	Transcriptional regulator
I3U38_RS06670	COG1611	Belongs to the LOG family
I3U38_RS06675	COG1611	Belongs to the LOG family
I3U38_RS06680	COG0318	PFAM AMP-dependent synthetase and ligase
I3U38_RS06690	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I3U38_RS06700	COG0463	Glycosyl transferase, family 2
I3U38_RS06715	COG0519	Catalyzes the synthesis of GMP from XMP
I3U38_RS06725	COG0297	glycogen (starch) synthase activity
I3U38_RS06750	COG3559	Exporter of polyketide antibiotics
I3U38_RS06755	COG1131	(ABC) transporter
I3U38_RS06760	COG1309	transcriptional regulator
I3U38_RS06770	COG1595	DNA-templated transcription, initiation
I3U38_RS06775	COG5662	AntiSigma factor
I3U38_RS06780	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I3U38_RS06850	COG0598	Magnesium transport protein CorA
I3U38_RS06855	COG1309	transcriptional regulator
I3U38_RS06875	COG2095	MarC family integral membrane protein
I3U38_RS06890	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I3U38_RS06895	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I3U38_RS06915	COG3835	regulator
I3U38_RS06920	COG1073	alpha beta
I3U38_RS06925	COG0508	dehydrogenase complex catalyzes the overall conversion of
I3U38_RS06925	COG0567	Dehydrogenase, E1 component
I3U38_RS06935	COG2814	Major facilitator Superfamily
I3U38_RS06995	COG0277	FAD linked oxidase domain protein
I3U38_RS07000	COG1028	Short-chain dehydrogenase reductase Sdr
I3U38_RS07015	COG0668	transmembrane transport
I3U38_RS07105	COG2814	Major facilitator Superfamily
I3U38_RS07135	COG0019	diaminopimelate decarboxylase activity
I3U38_RS07140	COG0460	homoserine dehydrogenase
I3U38_RS07145	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I3U38_RS07180	COG2890	protein-(glutamine-N5) methyltransferase activity
I3U38_RS07190	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I3U38_RS07200	COG0356	it plays a direct role in the translocation of protons across the membrane
I3U38_RS07205	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I3U38_RS07230	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I3U38_RS07290	COG0346	lactoylglutathione lyase activity
I3U38_RS07295	COG0183	Belongs to the thiolase family
I3U38_RS07300	COG2409	Drug exporters of the RND superfamily
I3U38_RS07315	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I3U38_RS07320	COG0366	Alpha amylase catalytic
I3U38_RS07325	COG0058	SHG alpha-glucan phosphorylase activity
I3U38_RS07340	COG1335	isochorismatase
I3U38_RS07350	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I3U38_RS07365	COG3191	aminopeptidase activity
I3U38_RS07410	COG0604	alcohol dehydrogenase
I3U38_RS07430	COG0318	PFAM AMP-dependent synthetase and ligase
I3U38_RS07445	COG0419	ATPase involved in DNA repair
I3U38_RS07450	COG1024	Enoyl-CoA hydratase
I3U38_RS07460	COG0243	molybdopterin cofactor binding
I3U38_RS07475	COG2188	Transcriptional regulator
I3U38_RS07530	COG0596	Alpha beta hydrolase
I3U38_RS07535	COG3757	hydrolase, family 25
I3U38_RS07550	COG1051	belongs to the nudix hydrolase family
I3U38_RS07570	COG1309	transcriptional regulator
I3U38_RS07585	COG4585	Histidine kinase
I3U38_RS07590	COG2197	response regulator
I3U38_RS07600	COG2239	Acts as a magnesium transporter
I3U38_RS07610	COG0300	oxidoreductase activity
I3U38_RS07620	COG0656	L-ascorbic acid biosynthetic process
I3U38_RS07635	COG1376	ErfK ybiS ycfS ynhG family protein
I3U38_RS07650	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I3U38_RS07655	COG0433	COG0433 Predicted ATPase
I3U38_RS07670	COG0300	oxidoreductase activity
I3U38_RS07685	COG1301	dicarboxylic acid transport
I3U38_RS07695	COG0531	amino acid
I3U38_RS07715	COG4424	Sulfotransferase
I3U38_RS07720	COG3119	arylsulfatase activity
I3U38_RS07755	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I3U38_RS07755	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I3U38_RS07795	COG2902	Dehydrogenase
I3U38_RS07800	COG0824	Thioesterase
I3U38_RS07815	COG0366	Alpha amylase catalytic
I3U38_RS07850	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I3U38_RS07870	COG1309	transcriptional regulator
I3U38_RS07885	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
I3U38_RS07905	COG0740	serine-type endopeptidase activity
I3U38_RS07910	COG0740	serine-type endopeptidase activity
I3U38_RS07960	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I3U38_RS07970	COG0674	pyruvate-flavodoxin oxidoreductase activity
I3U38_RS07970	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I3U38_RS07975	COG1013	pyruvate-flavodoxin oxidoreductase activity
I3U38_RS07985	COG1388	LysM domain
I3U38_RS08015	COG0525	valine-tRNA ligase activity
I3U38_RS08020	COG0285	dihydrofolate synthase activity
I3U38_RS08035	COG1530	ribonuclease E activity
I3U38_RS08035	COG1530	ribonuclease E activity
I3U38_RS08065	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I3U38_RS08085	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I3U38_RS08090	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I3U38_RS08095	COG0542	response to heat
I3U38_RS08105	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I3U38_RS08115	COG0406	alpha-ribazole phosphatase activity
I3U38_RS08120	COG2755	lipolytic protein G-D-S-L family
I3U38_RS08140	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I3U38_RS08175	COG2308	Evidence 4 Homologs of previously reported genes of
I3U38_RS08185	COG1305	Transglutaminase-like
I3U38_RS08215	COG3387	PFAM Glycoside hydrolase 15-related
I3U38_RS08230	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I3U38_RS08265	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
I3U38_RS08270	COG4208	sulfate ABC transporter
I3U38_RS08330	COG0484	heat shock protein binding
I3U38_RS08380	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I3U38_RS08410	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I3U38_RS08425	COG0076	glutamate decarboxylase activity
I3U38_RS08460	COG0318	PFAM AMP-dependent synthetase and ligase
I3U38_RS08465	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I3U38_RS08510	COG0423	glycine-tRNA ligase activity
I3U38_RS08515	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I3U38_RS08520	COG2515	1-aminocyclopropane-1-carboxylate deaminase
I3U38_RS08540	COG0358	DNA primase activity
I3U38_RS08605	COG0745	RESPONSE REGULATOR receiver
I3U38_RS08610	COG5002	protein histidine kinase activity
I3U38_RS08995	COG3179	chitinase
I3U38_RS09220	COG0488	(ABC) transporter
I3U38_RS09245	COG1960	acyl-CoA dehydrogenase activity
I3U38_RS09250	COG1335	isochorismatase
I3U38_RS09260	COG0058	SHG alpha-glucan phosphorylase activity
I3U38_RS09300	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I3U38_RS09305	COG1960	acyl-CoA dehydrogenase activity
I3U38_RS09310	COG0183	Belongs to the thiolase family
I3U38_RS09330	COG1228	amidohydrolase
I3U38_RS09360	COG0604	alcohol dehydrogenase
I3U38_RS09360	COG1028	Short-chain dehydrogenase reductase Sdr
I3U38_RS09360	COG3321	synthase
I3U38_RS09380	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I3U38_RS09410	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I3U38_RS09515	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I3U38_RS09560	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
I3U38_RS09565	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
I3U38_RS09625	COG0714	Associated with various cellular activities
I3U38_RS09650	COG0557	exoribonuclease II activity
I3U38_RS09660	COG0318	PFAM AMP-dependent synthetase and ligase
I3U38_RS09685	COG0174	glutamine synthetase
I3U38_RS09690	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I3U38_RS09720	COG2205	protein histidine kinase activity
I3U38_RS09750	COG0174	glutamine synthetase
I3U38_RS09760	COG0477	Major facilitator Superfamily
I3U38_RS09770	COG3486	L-lysine 6-monooxygenase (NADPH) activity
I3U38_RS09790	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I3U38_RS09795	COG0321	lipoyl(octanoyl) transferase activity
I3U38_RS09810	COG1872	DUF167
I3U38_RS09830	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I3U38_RS09840	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
I3U38_RS09845	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
I3U38_RS09875	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I3U38_RS09920	COG2010	Cytochrome c
I3U38_RS09925	COG1845	cytochrome c oxidase, subunit III
I3U38_RS09930	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I3U38_RS09965	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I3U38_RS09990	COG0003	Pfam Anion-transporting ATPase
I3U38_RS10000	COG0204	Acyl-transferase
I3U38_RS10005	COG5650	phosphatidylinositol metabolic process
I3U38_RS10015	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
I3U38_RS10040	COG0142	geranyltranstransferase activity
I3U38_RS10080	COG0768	penicillin binding
I3U38_RS10100	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I3U38_RS10110	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I3U38_RS10125	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I3U38_RS10150	COG0640	Transcriptional regulator
I3U38_RS10205	COG0154	amidase activity
I3U38_RS10215	COG2957	Belongs to the agmatine deiminase family
I3U38_RS10225	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I3U38_RS10235	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I3U38_RS10245	COG1028	Short-chain dehydrogenase reductase Sdr
I3U38_RS10275	COG2814	Major facilitator Superfamily
I3U38_RS10350	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3U38_RS10355	COG2030	dehydratase
I3U38_RS10375	COG1024	Enoyl-CoA hydratase
I3U38_RS10390	COG1309	transcriptional regulator
I3U38_RS10410	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I3U38_RS10455	COG2072	flavoprotein involved in K transport
I3U38_RS10470	COG0318	PFAM AMP-dependent synthetase and ligase
I3U38_RS10475	COG1960	acyl-CoA dehydrogenase activity
I3U38_RS10495	COG1960	acyl-CoA dehydrogenase activity
I3U38_RS10520	COG3621	Patatin-like phospholipase
I3U38_RS10580	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I3U38_RS10610	COG1968	undecaprenyl-diphosphatase activity
I3U38_RS10645	COG1218	3'(2'),5'-bisphosphate nucleotidase
I3U38_RS10655	COG1028	Short-chain dehydrogenase reductase Sdr
I3U38_RS10680	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I3U38_RS10690	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I3U38_RS10690	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
I3U38_RS10705	COG2860	membrane
I3U38_RS10715	COG1410	methionine synthase
I3U38_RS10715	COG0646	methionine synthase
I3U38_RS10720	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I3U38_RS10730	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I3U38_RS10765	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
I3U38_RS10770	COG1034	ATP synthesis coupled electron transport
I3U38_RS10775	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
I3U38_RS10780	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I3U38_RS10860	COG0513	Belongs to the DEAD box helicase family
I3U38_RS10895	COG0028	Belongs to the TPP enzyme family
I3U38_RS10910	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I3U38_RS10915	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
I3U38_RS10920	COG4122	O-methyltransferase activity
I3U38_RS10950	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I3U38_RS10955	COG4521	taurine ABC transporter
I3U38_RS10960	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
I3U38_RS10995	COG2378	regulation of single-species biofilm formation
I3U38_RS11000	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I3U38_RS11035	COG0300	oxidoreductase activity
I3U38_RS11090	COG1574	metal-dependent hydrolase with the TIM-barrel fold
I3U38_RS11100	COG0463	Glycosyl transferase, family 2
I3U38_RS11105	COG1028	Short-chain dehydrogenase reductase Sdr
I3U38_RS11130	COG3321	synthase
I3U38_RS11130	COG1028	Short-chain dehydrogenase reductase Sdr
I3U38_RS11130	COG0604	alcohol dehydrogenase
I3U38_RS11150	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I3U38_RS11160	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I3U38_RS11165	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3U38_RS11185	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
I3U38_RS11195	COG1404	Belongs to the peptidase S8 family
I3U38_RS11210	COG4842	Belongs to the WXG100 family
I3U38_RS11240	COG0464	growth
I3U38_RS11260	COG0583	DNA-binding transcription factor activity
I3U38_RS11290	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I3U38_RS11295	COG1169	isochorismate synthase
I3U38_RS11300	COG0789	Transcriptional regulator
I3U38_RS11305	COG1021	2,3-dihydroxybenzoate-AMP ligase
I3U38_RS11335	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
I3U38_RS11360	COG1028	Short-chain dehydrogenase reductase Sdr
I3U38_RS11360	COG0318	PFAM AMP-dependent synthetase and ligase
I3U38_RS11360	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I3U38_RS11360	COG0300	oxidoreductase activity
I3U38_RS11360	COG3321	synthase
I3U38_RS11375	COG1132	(ABC) transporter
I3U38_RS11380	COG2375	cellular response to nickel ion
I3U38_RS11380	COG1132	(ABC) transporter
I3U38_RS11385	COG0477	Major facilitator Superfamily
I3U38_RS11390	COG5285	phytanoyl-CoA dioxygenase
I3U38_RS11400	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I3U38_RS11405	COG0456	acetyltransferase
I3U38_RS11420	COG2837	iron assimilation
I3U38_RS11430	COG2186	Transcriptional regulator
I3U38_RS11435	COG2807	transmembrane transport
I3U38_RS11445	COG2409	Drug exporters of the RND superfamily
I3U38_RS11450	COG3629	intracellular signal transduction
I3U38_RS11455	COG1012	belongs to the aldehyde dehydrogenase family
I3U38_RS11495	COG0475	glutathione-regulated potassium exporter activity
I3U38_RS11565	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I3U38_RS11565	COG0237	dephospho-CoA kinase activity
I3U38_RS11750	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I3U38_RS11755	COG0072	phenylalanine-tRNA ligase activity
I3U38_RS11755	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I3U38_RS11765	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I3U38_RS11770	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I3U38_RS11775	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I3U38_RS11780	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I3U38_RS11785	COG1438	arginine binding
I3U38_RS11790	COG0137	argininosuccinate synthase activity
I3U38_RS11830	COG2835	tetraacyldisaccharide 4'-kinase activity
I3U38_RS11835	COG1309	transcriptional regulator
I3U38_RS11840	COG2094	Belongs to the DNA glycosylase MPG family
I3U38_RS11865	COG0647	UMP catabolic process
I3U38_RS11880	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I3U38_RS11900	COG0504	CTP synthase activity
I3U38_RS11905	COG0494	nUDIX hydrolase
I3U38_RS11925	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I3U38_RS11940	COG1160	GTP binding
I3U38_RS11950	COG1403	HNH endonuclease
I3U38_RS12030	COG3976	FMN-binding domain protein
I3U38_RS12030	COG1053	succinate dehydrogenase
I3U38_RS12060	COG1960	acyl-CoA dehydrogenase activity
I3U38_RS12120	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I3U38_RS12120	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I3U38_RS12135	COG1253	flavin adenine dinucleotide binding
I3U38_RS12140	COG1253	flavin adenine dinucleotide binding
I3U38_RS12150	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I3U38_RS12205	COG0832	Belongs to the urease beta subunit family
I3U38_RS12215	COG0830	nickel cation binding
I3U38_RS12230	COG1252	NADH dehydrogenase
I3U38_RS12240	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3U38_RS12275	COG0243	molybdopterin cofactor binding
I3U38_RS12285	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I3U38_RS12300	COG1546	Belongs to the CinA family
I3U38_RS12300	COG1058	Belongs to the CinA family
I3U38_RS12315	COG1741	Belongs to the pirin family
I3U38_RS12340	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
I3U38_RS12365	COG0277	FAD linked oxidase domain protein
I3U38_RS12375	COG1309	transcriptional regulator
I3U38_RS12390	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I3U38_RS12395	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I3U38_RS12400	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I3U38_RS12425	COG4290	ribonuclease
I3U38_RS12455	COG0791	NLP P60 protein
I3U38_RS12455	COG3883	PFAM NLP P60 protein
I3U38_RS12490	COG0477	Major facilitator Superfamily
I3U38_RS12510	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I3U38_RS12515	COG0067	glutamate synthase
I3U38_RS12515	COG0070	glutamate synthase
I3U38_RS12515	COG0069	glutamate synthase activity
I3U38_RS12540	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I3U38_RS12555	COG1960	acyl-CoA dehydrogenase activity
I3U38_RS12570	COG0443	Heat shock 70 kDa protein
I3U38_RS12575	COG0596	Alpha beta hydrolase
I3U38_RS12595	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I3U38_RS12605	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
I3U38_RS12630	COG2890	protein-(glutamine-N5) methyltransferase activity
I3U38_RS12700	COG1982	Orn Lys Arg decarboxylase major
I3U38_RS12755	COG0028	Belongs to the TPP enzyme family
I3U38_RS12765	COG0318	PFAM AMP-dependent synthetase and ligase
I3U38_RS12785	COG1309	transcriptional regulator
I3U38_RS12790	COG2957	Belongs to the agmatine deiminase family
I3U38_RS12795	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I3U38_RS12810	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I3U38_RS12860	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
I3U38_RS12875	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
I3U38_RS12895	COG0640	Transcriptional regulator
I3U38_RS12905	COG0798	PFAM Bile acid sodium symporter
I3U38_RS12910	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I3U38_RS12915	COG0390	transport system, permease component
I3U38_RS12935	COG0318	PFAM AMP-dependent synthetase and ligase
I3U38_RS12940	COG0179	Fumarylacetoacetate (FAA) hydrolase
I3U38_RS12965	COG0745	RESPONSE REGULATOR receiver
I3U38_RS12970	COG2205	protein histidine kinase activity
I3U38_RS12985	COG1917	Cupin 2, conserved barrel domain protein
I3U38_RS12990	COG3707	response regulator
I3U38_RS13030	COG3467	pyridoxamine 5'-phosphate
I3U38_RS13035	COG4308	Limonene-1,2-epoxide hydrolase catalytic domain
I3U38_RS13055	COG0640	Transcriptional regulator
I3U38_RS13075	COG1309	transcriptional regulator
I3U38_RS13080	COG2072	flavoprotein involved in K transport
I3U38_RS13090	COG0318	PFAM AMP-dependent synthetase and ligase
I3U38_RS13095	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I3U38_RS13100	COG0561	phosphatase activity
I3U38_RS13105	COG0673	inositol 2-dehydrogenase activity
I3U38_RS13110	COG0738	Major facilitator superfamily
I3U38_RS13195	COG1271	oxidase subunit
I3U38_RS13200	COG1294	oxidase, subunit
I3U38_RS13205	COG4988	ABC transporter
I3U38_RS13210	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I3U38_RS13235	COG1946	Acyl-CoA thioesterase
I3U38_RS13280	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I3U38_RS13285	COG1846	Transcriptional regulator
I3U38_RS13310	COG2072	flavoprotein involved in K transport
I3U38_RS13315	COG0657	acetylesterase activity
I3U38_RS13365	COG0483	inositol monophosphate 1-phosphatase activity
I3U38_RS13375	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I3U38_RS13380	COG0131	Imidazoleglycerol-phosphate dehydratase
I3U38_RS13385	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I3U38_RS13410	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I3U38_RS13425	COG1309	transcriptional regulator
I3U38_RS13440	COG0583	DNA-binding transcription factor activity
I3U38_RS13445	COG0579	oxidoreductase
I3U38_RS13485	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I3U38_RS13485	COG2755	lipolytic protein G-D-S-L family
I3U38_RS13540	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I3U38_RS13560	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I3U38_RS13565	COG2814	Major facilitator Superfamily
I3U38_RS13570	COG0583	DNA-binding transcription factor activity
I3U38_RS13620	COG2239	Acts as a magnesium transporter
I3U38_RS13650	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I3U38_RS13660	COG2304	oxidoreductase activity
I3U38_RS13670	COG0714	Associated with various cellular activities
I3U38_RS13680	COG0791	NLP P60 protein
I3U38_RS13680	COG3883	PFAM NLP P60 protein
I3U38_RS13690	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I3U38_RS13695	COG1309	transcriptional regulator
I3U38_RS13720	COG0488	(ABC) transporter
I3U38_RS13735	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I3U38_RS13750	COG0456	acetyltransferase
I3U38_RS13760	COG2151	metal-sulfur cluster biosynthetic enzyme
I3U38_RS13775	COG0396	ATPase activity
I3U38_RS13800	COG1131	(ABC) transporter
I3U38_RS13840	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I3U38_RS13860	COG0583	DNA-binding transcription factor activity
I3U38_RS13865	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I3U38_RS13935	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I3U38_RS13995	COG0531	amino acid
I3U38_RS14050	COG2011	ABC-type metal ion transport system permease component
I3U38_RS14055	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I3U38_RS14075	COG0477	Major facilitator Superfamily
I3U38_RS14110	COG0657	acetylesterase activity
I3U38_RS14115	COG1953	Uracil, thiamine, allantoin
I3U38_RS14125	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I3U38_RS14130	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I3U38_RS14140	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I3U38_RS14150	COG1758	RNA polymerase activity
I3U38_RS14170	COG0284	orotidine-5'-phosphate decarboxylase activity
I3U38_RS14175	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I3U38_RS14180	COG0505	Belongs to the CarA family
I3U38_RS14200	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
I3U38_RS14220	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I3U38_RS14230	COG0006	proline dipeptidase activity
I3U38_RS14245	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I3U38_RS14250	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I3U38_RS14265	COG4106	trans-aconitate 2-methyltransferase activity
I3U38_RS14280	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I3U38_RS14295	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I3U38_RS14345	COG0701	Predicted permease
I3U38_RS14370	COG2272	Belongs to the type-B carboxylesterase lipase family
I3U38_RS14410	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I3U38_RS14420	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I3U38_RS14430	COG0747	negative chemotaxis
I3U38_RS14435	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I3U38_RS14450	COG2255	four-way junction helicase activity
I3U38_RS14460	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
I3U38_RS14495	COG1946	Acyl-CoA thioesterase
I3U38_RS14500	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
I3U38_RS14510	COG0438	transferase activity, transferring glycosyl groups
I3U38_RS14550	COG4762	Protein conserved in bacteria
I3U38_RS14605	COG1309	transcriptional regulator
I3U38_RS14630	COG3878	Protein conserved in bacteria
I3U38_RS14670	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I3U38_RS14685	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I3U38_RS14685	COG2080	2 iron, 2 sulfur cluster binding
I3U38_RS14700	COG0402	S-adenosylhomocysteine deaminase activity
I3U38_RS14720	COG2233	PERMEase
I3U38_RS14740	COG1953	Uracil, thiamine, allantoin
I3U38_RS14750	COG1301	dicarboxylic acid transport
I3U38_RS14760	COG4266	Belongs to the allantoicase family
I3U38_RS14790	COG2267	carboxylic ester hydrolase activity
I3U38_RS14795	COG1960	acyl-CoA dehydrogenase activity
I3U38_RS14800	COG1028	Short-chain dehydrogenase reductase Sdr
I3U38_RS14815	COG0183	Belongs to the thiolase family
I3U38_RS14845	COG0477	Major facilitator Superfamily
I3U38_RS14900	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I3U38_RS14910	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I3U38_RS14950	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I3U38_RS14975	COG3253	May function as heme-dependent peroxidase
I3U38_RS14980	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
I3U38_RS14985	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I3U38_RS14995	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
I3U38_RS15010	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I3U38_RS15015	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I3U38_RS15020	COG0531	amino acid
I3U38_RS15025	COG0569	domain protein
I3U38_RS15055	COG0702	epimerase
I3U38_RS15070	COG0756	dUTP diphosphatase activity
I3U38_RS15115	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I3U38_RS15165	COG3220	belongs to the UPF0276 family
I3U38_RS15240	COG1388	LysM domain
I3U38_RS15255	COG1960	acyl-CoA dehydrogenase activity
I3U38_RS15265	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I3U38_RS15285	COG1196	nuclear chromosome segregation
I3U38_RS15305	COG1126	abc transporter atp-binding protein
I3U38_RS15310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I3U38_RS15315	COG0765	amino acid transport
I3U38_RS15320	COG0765	amino acid transport
I3U38_RS15370	COG4308	Limonene-1,2-epoxide hydrolase catalytic domain
I3U38_RS15375	COG4308	Limonene-1,2-epoxide hydrolase catalytic domain
I3U38_RS15390	COG1842	Phage shock protein A
I3U38_RS15395	COG1396	sequence-specific DNA binding
I3U38_RS15405	COG1028	Short-chain dehydrogenase reductase Sdr
I3U38_RS15415	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I3U38_RS15470	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I3U38_RS15475	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I3U38_RS15490	COG3214	Protein conserved in bacteria
I3U38_RS15530	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I3U38_RS15540	COG0659	secondary active sulfate transmembrane transporter activity
I3U38_RS15550	COG0686	Belongs to the AlaDH PNT family
I3U38_RS15565	COG1028	Short-chain dehydrogenase reductase Sdr
I3U38_RS15635	COG2977	Belongs to the P-Pant transferase superfamily
I3U38_RS15640	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I3U38_RS15660	COG1960	acyl-CoA dehydrogenase activity
I3U38_RS15665	COG1960	acyl-CoA dehydrogenase activity
I3U38_RS15670	COG1024	Enoyl-CoA hydratase
I3U38_RS15695	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I3U38_RS15720	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I3U38_RS15720	COG1017	nitric oxide dioxygenase activity
I3U38_RS15725	COG1959	2 iron, 2 sulfur cluster binding
I3U38_RS15770	COG1648	precorrin-2 dehydrogenase activity
I3U38_RS15770	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I3U38_RS15795	COG0604	alcohol dehydrogenase
I3U38_RS15795	COG1028	Short-chain dehydrogenase reductase Sdr
I3U38_RS15795	COG3321	synthase
I3U38_RS15855	COG0579	oxidoreductase
I3U38_RS15875	COG1492	cobalamin metabolic process
I3U38_RS15885	COG1376	ErfK ybiS ycfS ynhG family protein
I3U38_RS15910	COG0750	zinc metalloprotease
I3U38_RS15935	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I3U38_RS16000	COG0528	UMP kinase activity
I3U38_RS16005	COG3973	AAA domain
I3U38_RS16020	COG2723	6-phospho-beta-galactosidase activity
I3U38_RS16055	COG1309	transcriptional regulator
I3U38_RS16095	COG0583	DNA-binding transcription factor activity
I3U38_RS16120	COG0792	nuclease activity
I3U38_RS16180	COG0336	Belongs to the RNA methyltransferase TrmD family
I3U38_RS16220	COG1686	Belongs to the peptidase S11 family
I3U38_RS16240	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I3U38_RS16260	COG1304	FMN binding
I3U38_RS16285	COG1254	Belongs to the acylphosphatase family
I3U38_RS16310	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
I3U38_RS16315	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
I3U38_RS16335	COG0571	ribonuclease III activity
I3U38_RS16345	COG3599	regulation of cell shape
I3U38_RS16385	COG0742	ribosomal rna small subunit methyltransferase
I3U38_RS16390	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
I3U38_RS16405	COG0657	acetylesterase activity
I3U38_RS16410	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3U38_RS16430	COG2124	cytochrome p450
I3U38_RS16445	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I3U38_RS16450	COG1461	Dihydroxyacetone kinase
I3U38_RS16460	COG1024	Enoyl-CoA hydratase
I3U38_RS16485	COG1181	Belongs to the D-alanine--D-alanine ligase family
I3U38_RS16490	COG0626	cystathionine gamma-synthase activity
I3U38_RS16495	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I3U38_RS16560	COG0179	Fumarylacetoacetate (FAA) hydrolase
I3U38_RS16575	COG2271	Major facilitator Superfamily
I3U38_RS16610	COG0583	DNA-binding transcription factor activity
I3U38_RS16620	COG0778	Nitroreductase
I3U38_RS16635	COG1309	transcriptional regulator
I3U38_RS16640	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I3U38_RS16645	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I3U38_RS16650	COG2124	cytochrome p450
I3U38_RS16680	COG0440	acetolactate synthase activity
I3U38_RS16695	COG1748	Saccharopine dehydrogenase
I3U38_RS16700	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I3U38_RS16720	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I3U38_RS16740	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I3U38_RS16750	COG2272	Belongs to the type-B carboxylesterase lipase family
I3U38_RS16765	COG0745	RESPONSE REGULATOR receiver
I3U38_RS16770	COG2205	protein histidine kinase activity
I3U38_RS16795	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I3U38_RS16825	COG1024	Enoyl-CoA hydratase
I3U38_RS16830	COG0778	Nitroreductase
I3U38_RS16840	COG2252	PERMEase
I3U38_RS16880	COG2197	response regulator
I3U38_RS16885	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I3U38_RS16895	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I3U38_RS16920	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I3U38_RS16935	COG1309	transcriptional regulator
I3U38_RS16965	COG0110	maltose O-acetyltransferase activity
I3U38_RS16970	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I3U38_RS16995	COG1119	ATPase activity
I3U38_RS17005	COG2364	Membrane
I3U38_RS17010	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I3U38_RS17025	COG4607	ABC-type enterochelin transport system periplasmic component
I3U38_RS17075	COG1064	alcohol dehydrogenase
I3U38_RS17095	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I3U38_RS17100	COG1028	Short-chain dehydrogenase reductase Sdr
I3U38_RS17160	COG0477	Major facilitator Superfamily
I3U38_RS17180	COG1028	Short-chain dehydrogenase reductase Sdr
I3U38_RS17210	COG1028	Short-chain dehydrogenase reductase Sdr
I3U38_RS17235	COG1335	isochorismatase
I3U38_RS17245	COG2855	membrane
I3U38_RS17255	COG0318	PFAM AMP-dependent synthetase and ligase
I3U38_RS17270	COG1028	Short-chain dehydrogenase reductase Sdr
I3U38_RS17280	COG1028	Short-chain dehydrogenase reductase Sdr
I3U38_RS17285	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I3U38_RS17345	COG2272	Belongs to the type-B carboxylesterase lipase family
I3U38_RS17360	COG0183	Belongs to the thiolase family
I3U38_RS17395	COG1309	transcriptional regulator
I3U38_RS17425	COG0789	Transcriptional regulator
I3U38_RS17435	COG0028	Belongs to the TPP enzyme family
I3U38_RS17460	COG2177	Part of the ABC transporter FtsEX involved in
I3U38_RS17465	COG2884	Cell division ATP-binding protein ftsE
I3U38_RS17475	COG0668	transmembrane transport
I3U38_RS17515	COG0483	inositol monophosphate 1-phosphatase activity
I3U38_RS17520	COG1960	acyl-CoA dehydrogenase activity
I3U38_RS17525	COG1960	acyl-CoA dehydrogenase activity
I3U38_RS17540	COG0318	PFAM AMP-dependent synthetase and ligase
I3U38_RS17550	COG0542	response to heat
I3U38_RS17595	COG3480	Lon protease (S16) C-terminal proteolytic domain
I3U38_RS17600	COG3011	Protein conserved in bacteria
I3U38_RS17615	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I3U38_RS17620	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I3U38_RS17630	COG0300	oxidoreductase activity
I3U38_RS17635	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I3U38_RS17670	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I3U38_RS17670	COG0475	glutathione-regulated potassium exporter activity
I3U38_RS17685	COG0596	Alpha beta hydrolase
I3U38_RS17700	COG0745	RESPONSE REGULATOR receiver
I3U38_RS17710	COG2146	nitrite reductase [NAD(P)H] activity
I3U38_RS17710	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I3U38_RS17715	COG2223	nitrite transmembrane transporter activity
I3U38_RS17755	COG0513	Belongs to the DEAD box helicase family
I3U38_RS17770	COG0406	alpha-ribazole phosphatase activity
I3U38_RS17790	COG1597	lipid kinase activity
I3U38_RS17805	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
I3U38_RS17815	COG1595	DNA-templated transcription, initiation
I3U38_RS17820	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I3U38_RS17825	COG2135	peptidase activity
I3U38_RS17830	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I3U38_RS17835	COG1162	GTPase activity
I3U38_RS17870	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I3U38_RS17965	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I3U38_RS17970	COG0604	alcohol dehydrogenase
I3U38_RS17970	COG3321	synthase
I3U38_RS17975	COG0604	alcohol dehydrogenase
I3U38_RS17975	COG3321	synthase
I3U38_RS17980	COG1960	acyl-CoA dehydrogenase activity
I3U38_RS17990	COG0318	PFAM AMP-dependent synthetase and ligase
I3U38_RS17995	COG0653	protein targeting
I3U38_RS18005	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I3U38_RS18010	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I3U38_RS18020	COG1309	transcriptional regulator
I3U38_RS18035	COG5401	PFAM Sporulation and spore germination
I3U38_RS18040	COG5002	protein histidine kinase activity
I3U38_RS18050	COG0318	PFAM AMP-dependent synthetase and ligase
I3U38_RS18055	COG1285	pathogenesis
I3U38_RS18085	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I3U38_RS18090	COG0531	amino acid
I3U38_RS18100	COG1482	cell wall glycoprotein biosynthetic process
I3U38_RS18130	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I3U38_RS18135	COG0778	Nitroreductase
I3U38_RS18135	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
I3U38_RS18150	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I3U38_RS18165	COG1316	TRANSCRIPTIONal
I3U38_RS18185	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I3U38_RS18195	COG2175	clavaminate synthase activity
I3U38_RS18220	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
I3U38_RS18220	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
I3U38_RS18230	COG0318	PFAM AMP-dependent synthetase and ligase
I3U38_RS18245	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I3U38_RS18265	COG3265	gluconokinase activity
I3U38_RS18270	COG1960	acyl-CoA dehydrogenase activity
I3U38_RS18285	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3U38_RS18305	COG4770	biotin carboxylase activity
I3U38_RS18315	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I3U38_RS18335	COG1012	belongs to the aldehyde dehydrogenase family
I3U38_RS18340	COG1309	transcriptional regulator
I3U38_RS18345	COG1201	RNA secondary structure unwinding
I3U38_RS18360	COG0564	pseudouridine synthase activity
I3U38_RS18380	COG1473	amidohydrolase
I3U38_RS18380	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
I3U38_RS18395	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I3U38_RS18410	COG3883	PFAM NLP P60 protein
I3U38_RS18410	COG0791	NLP P60 protein
I3U38_RS18455	COG2009	succinate dehydrogenase
I3U38_RS18470	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I3U38_RS18475	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I3U38_RS18480	COG1595	DNA-templated transcription, initiation
I3U38_RS18495	COG1686	Belongs to the peptidase S11 family
I3U38_RS18510	COG0708	Exodeoxyribonuclease III
I3U38_RS18570	COG1733	regulation of RNA biosynthetic process
I3U38_RS18575	COG2910	NAD(P)H-binding
I3U38_RS18580	COG1131	(ABC) transporter
I3U38_RS18580	COG0842	Transport permease protein
I3U38_RS18580	COG1716	ATPase activity
I3U38_RS18585	COG1357	PFAM Pentapeptide repeats (8 copies)
I3U38_RS18600	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I3U38_RS18605	COG0587	DNA-directed DNA polymerase activity
I3U38_RS18610	COG1073	alpha beta
I3U38_RS18615	COG1309	transcriptional regulator
I3U38_RS18680	COG0519	Catalyzes the synthesis of GMP from XMP
I3U38_RS18680	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I3U38_RS18690	COG0516	GMP reductase activity
I3U38_RS18750	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I3U38_RS18765	COG0456	acetyltransferase
I3U38_RS18785	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I3U38_RS18790	COG0076	glutamate decarboxylase activity
I3U38_RS18800	COG2267	carboxylic ester hydrolase activity
I3U38_RS18805	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I3U38_RS18830	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3U38_RS18840	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I3U38_RS18845	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I3U38_RS18880	COG1404	Belongs to the peptidase S8 family
I3U38_RS18910	COG2267	carboxylic ester hydrolase activity
I3U38_RS18965	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I3U38_RS18970	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I3U38_RS18980	COG2268	Band 7 protein
I3U38_RS18990	COG1088	dTDP-glucose 4,6-dehydratase activity
I3U38_RS18995	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
I3U38_RS19040	COG0616	signal peptide processing
I3U38_RS19055	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3U38_RS19075	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I3U38_RS19085	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I3U38_RS19095	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I3U38_RS19110	COG2272	Belongs to the type-B carboxylesterase lipase family
I3U38_RS19135	COG0477	Major facilitator Superfamily
I3U38_RS19150	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I3U38_RS19190	COG0088	Forms part of the polypeptide exit tunnel
I3U38_RS19195	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I3U38_RS19200	COG0051	transcription antitermination factor activity, RNA binding
I3U38_RS19235	COG0531	amino acid
I3U38_RS19265	COG0535	radical SAM domain protein
I3U38_RS19290	COG1834	amidinotransferase
I3U38_RS19295	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I3U38_RS19300	COG0531	amino acid
I3U38_RS19345	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I3U38_RS19350	COG1309	transcriptional regulator
I3U38_RS19375	COG1024	Enoyl-CoA hydratase
I3U38_RS19390	COG1960	acyl-CoA dehydrogenase activity
I3U38_RS19420	COG1113	amino acid transport
I3U38_RS19435	COG0085	RNA polymerase activity
I3U38_RS19440	COG0243	molybdopterin cofactor binding
I3U38_RS19495	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I3U38_RS19510	COG0277	FAD linked oxidase domain protein
I3U38_RS19530	COG4941	Belongs to the sigma-70 factor family
I3U38_RS19565	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I3U38_RS19605	COG0783	Belongs to the Dps family
I3U38_RS19610	COG0693	protein deglycase activity
I3U38_RS19655	COG1404	Belongs to the peptidase S8 family
I3U38_RS19675	COG1280	lysine exporter protein (LysE YggA)
I3U38_RS19745	COG0501	Belongs to the peptidase M48B family
I3U38_RS19750	COG0142	geranyltranstransferase activity
I3U38_RS19755	COG0644	oxidoreductase
I3U38_RS19765	COG0438	transferase activity, transferring glycosyl groups
I3U38_RS19785	COG4948	Mandelate Racemase Muconate Lactonizing
I3U38_RS19810	COG3706	GGDEF domain
I3U38_RS19825	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I3U38_RS19835	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I3U38_RS19840	COG1028	Short-chain dehydrogenase reductase Sdr
I3U38_RS19845	COG4221	oxidoreductase activity
I3U38_RS19895	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
I3U38_RS19900	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I3U38_RS19940	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I3U38_RS19985	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I3U38_RS19990	COG1333	cytochrome c biogenesis protein
I3U38_RS19995	COG0785	Cytochrome C biogenesis protein
I3U38_RS20005	COG0406	alpha-ribazole phosphatase activity
I3U38_RS20025	COG3590	peptidase
I3U38_RS20075	COG1587	Uroporphyrinogen-III synthase
I3U38_RS20075	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I3U38_RS20100	COG2030	dehydratase
I3U38_RS20125	COG2070	2-Nitropropane dioxygenase
I3U38_RS20150	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I3U38_RS20155	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I3U38_RS20260	COG1309	transcriptional regulator
I3U38_RS20270	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I3U38_RS20320	COG2072	flavoprotein involved in K transport
I3U38_RS20335	COG2072	flavoprotein involved in K transport
I3U38_RS20340	COG1028	Short-chain dehydrogenase reductase Sdr
I3U38_RS20345	COG0657	acetylesterase activity
I3U38_RS20350	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I3U38_RS20360	COG0745	RESPONSE REGULATOR receiver
I3U38_RS20365	COG5002	protein histidine kinase activity
I3U38_RS20375	COG2072	flavoprotein involved in K transport
I3U38_RS20390	COG0300	oxidoreductase activity
I3U38_RS20445	COG2814	Major facilitator Superfamily
I3U38_RS20450	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I3U38_RS20545	COG2733	membrane
I3U38_RS20555	COG2326	polyphosphate kinase activity
I3U38_RS20560	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I3U38_RS20595	COG2224	Isocitrate lyase
I3U38_RS20640	COG2226	methyltransferase
I3U38_RS20690	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I3U38_RS20725	COG0667	Aldo Keto reductase
I3U38_RS20750	COG4552	Acetyltransferase involved in intracellular survival and related
I3U38_RS20755	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3U38_RS20780	COG1505	serine-type exopeptidase activity
I3U38_RS20800	COG1073	alpha beta
I3U38_RS20805	COG2326	polyphosphate kinase activity
I3U38_RS20820	COG2223	nitrite transmembrane transporter activity
I3U38_RS20825	COG0640	Transcriptional regulator
I3U38_RS20855	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
I3U38_RS20875	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I3U38_RS20900	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I3U38_RS20905	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I3U38_RS20910	COG1028	Short-chain dehydrogenase reductase Sdr
I3U38_RS20920	COG1960	acyl-CoA dehydrogenase activity
I3U38_RS20925	COG1960	acyl-CoA dehydrogenase activity
I3U38_RS20930	COG0318	PFAM AMP-dependent synthetase and ligase
I3U38_RS20940	COG2070	2-Nitropropane dioxygenase
I3U38_RS20950	COG1024	Enoyl-CoA hydratase
I3U38_RS20955	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I3U38_RS20960	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3U38_RS20995	COG4638	Rieske (2fe-2S)
I3U38_RS21035	COG0175	sulfate reduction
I3U38_RS21105	COG2814	Major facilitator Superfamily
I3U38_RS21115	COG0351	phosphomethylpyrimidine kinase
I3U38_RS21125	COG1252	NADH dehydrogenase
I3U38_RS21135	COG1309	transcriptional regulator
I3U38_RS21145	COG1012	belongs to the aldehyde dehydrogenase family
I3U38_RS21180	COG0494	nUDIX hydrolase
I3U38_RS21190	COG2234	aminopeptidase activity
I3U38_RS21195	COG2234	aminopeptidase activity
I3U38_RS21205	COG1131	(ABC) transporter
I3U38_RS21210	COG2022	thiamine diphosphate biosynthetic process
I3U38_RS21245	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I3U38_RS21250	COG0515	serine threonine protein kinase
I3U38_RS21255	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I3U38_RS21285	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I3U38_RS21290	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3U38_RS21295	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3U38_RS21300	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3U38_RS21310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I3U38_RS21315	COG1126	abc transporter atp-binding protein
I3U38_RS21355	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
I3U38_RS21390	COG1994	Peptidase M50
I3U38_RS21410	COG0586	Pfam SNARE associated Golgi protein
I3U38_RS21440	COG4221	oxidoreductase activity
I3U38_RS21460	COG0542	response to heat
I3U38_RS21485	COG0789	Transcriptional regulator
I3U38_RS21490	COG0484	heat shock protein binding
I3U38_RS21495	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I3U38_RS21565	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I3U38_RS21565	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I3U38_RS21605	COG2181	nitrate reductase activity
I3U38_RS21605	COG0247	lactate metabolic process
I3U38_RS21615	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I3U38_RS21655	COG3345	alpha-galactosidase
I3U38_RS21660	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I3U38_RS21665	COG1305	Transglutaminase-like
I3U38_RS21680	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I3U38_RS21750	COG1012	belongs to the aldehyde dehydrogenase family
I3U38_RS21760	COG0454	-acetyltransferase
I3U38_RS21815	COG1028	Short-chain dehydrogenase reductase Sdr
I3U38_RS21820	COG1960	acyl-CoA dehydrogenase activity
I3U38_RS21835	COG3268	Saccharopine dehydrogenase
I3U38_RS21840	COG0318	PFAM AMP-dependent synthetase and ligase
I3U38_RS21845	COG3285	dna ligase
I3U38_RS21845	COG1793	dna ligase
I3U38_RS21850	COG0494	nUDIX hydrolase
I3U38_RS21860	COG2902	Dehydrogenase
I3U38_RS21865	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I3U38_RS21880	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I3U38_RS21900	COG1309	transcriptional regulator
I3U38_RS21915	COG0778	Nitroreductase
I3U38_RS21920	COG0179	Fumarylacetoacetate (FAA) hydrolase
I3U38_RS21945	COG0179	Fumarylacetoacetate (FAA) hydrolase
I3U38_RS21950	COG0318	PFAM AMP-dependent synthetase and ligase
I3U38_RS21955	COG1396	sequence-specific DNA binding
I3U38_RS21960	COG1414	Transcriptional regulator
I3U38_RS21975	COG2267	carboxylic ester hydrolase activity
I3U38_RS21980	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
I3U38_RS21995	COG4638	Rieske (2fe-2S)
I3U38_RS22000	COG3321	synthase
I3U38_RS22000	COG0604	alcohol dehydrogenase
I3U38_RS22000	COG1028	Short-chain dehydrogenase reductase Sdr
I3U38_RS22005	COG3384	dioxygenase
I3U38_RS22010	COG3971	2-oxopent-4-enoate hydratase activity
I3U38_RS22025	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I3U38_RS22030	COG0318	PFAM AMP-dependent synthetase and ligase
I3U38_RS22065	COG1309	transcriptional regulator
I3U38_RS22090	COG1309	transcriptional regulator
I3U38_RS22095	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
I3U38_RS22110	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I3U38_RS22115	COG1984	allophanate hydrolase subunit 2
I3U38_RS22180	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
I3U38_RS22185	COG1802	Transcriptional regulator
I3U38_RS22215	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I3U38_RS22225	COG0473	3-isopropylmalate dehydrogenase activity
I3U38_RS22240	COG1053	succinate dehydrogenase
I3U38_RS22260	COG0640	Transcriptional regulator
I3U38_RS22310	COG2318	DinB family
I3U38_RS22315	COG1960	acyl-CoA dehydrogenase activity
I3U38_RS22330	COG1660	Displays ATPase and GTPase activities
I3U38_RS22340	COG0183	Belongs to the thiolase family
I3U38_RS22345	COG1028	Short-chain dehydrogenase reductase Sdr
I3U38_RS22350	COG2030	dehydratase
I3U38_RS22365	COG0659	secondary active sulfate transmembrane transporter activity
I3U38_RS22370	COG1309	transcriptional regulator
I3U38_RS22375	COG0861	Integral membrane protein TerC family
I3U38_RS22400	COG0318	PFAM AMP-dependent synthetase and ligase
I3U38_RS22415	COG1472	Belongs to the glycosyl hydrolase 3 family
I3U38_RS22420	COG4941	Belongs to the sigma-70 factor family
I3U38_RS22485	COG4981	capsule polysaccharide biosynthetic process
I3U38_RS22525	COG0438	transferase activity, transferring glycosyl groups
I3U38_RS22570	COG1250	3-hydroxyacyl-CoA dehydrogenase
I3U38_RS22615	COG2197	response regulator
I3U38_RS22620	COG3850	Histidine kinase
I3U38_RS22640	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
I3U38_RS22670	COG2409	Drug exporters of the RND superfamily
I3U38_RS22715	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I3U38_RS22725	COG2197	response regulator
I3U38_RS22755	COG2353	YceI-like domain
I3U38_RS22770	COG2409	Drug exporters of the RND superfamily
I3U38_RS22785	COG4552	Acetyltransferase involved in intracellular survival and related
I3U38_RS22790	COG1832	CoA-binding protein
I3U38_RS22805	COG3590	peptidase
I3U38_RS22810	COG1376	ErfK ybiS ycfS ynhG family protein
I3U38_RS22815	COG1960	acyl-CoA dehydrogenase activity
I3U38_RS22825	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I3U38_RS22835	COG1937	Protein conserved in bacteria
I3U38_RS22860	COG1012	belongs to the aldehyde dehydrogenase family
I3U38_RS22865	COG4122	O-methyltransferase activity
I3U38_RS22880	COG2267	carboxylic ester hydrolase activity
I3U38_RS22910	COG1704	LemA family
I3U38_RS22920	COG0318	PFAM AMP-dependent synthetase and ligase
I3U38_RS22975	COG1024	Enoyl-CoA hydratase
I3U38_RS22980	COG1802	Transcriptional regulator
I3U38_RS22990	COG2267	carboxylic ester hydrolase activity
I3U38_RS22995	COG1309	transcriptional regulator
I3U38_RS23025	COG0435	Glutathione S-transferase
I3U38_RS23065	COG1024	Enoyl-CoA hydratase
I3U38_RS23075	COG2211	Major facilitator Superfamily
I3U38_RS23080	COG2365	Tyrosine phosphatase family
I3U38_RS23130	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I3U38_RS23145	COG1028	Short-chain dehydrogenase reductase Sdr
I3U38_RS23150	COG1012	belongs to the aldehyde dehydrogenase family
I3U38_RS23165	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I3U38_RS23170	COG1960	acyl-CoA dehydrogenase activity
I3U38_RS23175	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
I3U38_RS23190	COG2226	methyltransferase
I3U38_RS23205	COG3800	Transcriptional regulator
I3U38_RS23205	COG1396	sequence-specific DNA binding
I3U38_RS23215	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
I3U38_RS23255	COG0318	PFAM AMP-dependent synthetase and ligase
I3U38_RS23315	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I3U38_RS23325	COG0129	dihydroxy-acid dehydratase activity
I3U38_RS23345	COG2186	Transcriptional regulator
I3U38_RS23375	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I3U38_RS23380	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I3U38_RS23390	COG0723	plastoquinol--plastocyanin reductase activity
I3U38_RS23410	COG1028	Short-chain dehydrogenase reductase Sdr
I3U38_RS23450	COG1028	Short-chain dehydrogenase reductase Sdr
I3U38_RS23465	COG0318	PFAM AMP-dependent synthetase and ligase
I3U38_RS23470	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I3U38_RS23475	COG1136	(ABC) transporter
I3U38_RS23485	COG1104	cysteine desulfurase activity
I3U38_RS23545	COG1309	transcriptional regulator
I3U38_RS23555	COG1819	glycosyl
I3U38_RS23600	COG1819	glycosyl
I3U38_RS23715	COG3263	regulation of cellular component size
I3U38_RS23795	COG1595	DNA-templated transcription, initiation
I3U38_RS23805	COG0783	Belongs to the Dps family
I3U38_RS23850	COG1252	NADH dehydrogenase
I3U38_RS23870	COG1937	Protein conserved in bacteria
I3U38_RS23895	COG1403	HNH endonuclease
I3U38_RS23970	COG2140	Oxalate decarboxylase
I3U38_RS23995	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
I3U38_RS24015	COG1376	ErfK ybiS ycfS ynhG family protein
I3U38_RS24035	COG2030	dehydratase
I3U38_RS24040	COG0488	(ABC) transporter
I3U38_RS24045	COG3757	hydrolase, family 25
I3U38_RS24110	COG0583	DNA-binding transcription factor activity
I3U38_RS24120	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3U38_RS24135	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I3U38_RS24140	COG3757	hydrolase, family 25
I3U38_RS24350	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I3U38_RS24380	COG0745	RESPONSE REGULATOR receiver
I3U38_RS24385	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I3U38_RS24445	COG0640	Transcriptional regulator
I3U38_RS24450	COG0640	Transcriptional regulator
I3U38_RS24455	COG0798	PFAM Bile acid sodium symporter
I3U38_RS24460	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I3U38_RS24465	COG0446	pyridine nucleotide-disulphide oxidoreductase
I3U38_RS24475	COG0717	Belongs to the dCTP deaminase family
I3U38_RS24515	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
I3U38_RS24540	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I3U38_RS24550	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I3U38_RS24585	COG0454	-acetyltransferase
I3U38_RS24630	COG0629	single-stranded DNA binding
I3U38_RS24645	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I3U38_RS24675	COG1260	myo-inositol-1-phosphate synthase
I3U38_RS24685	COG1113	amino acid transport
I3U38_RS24700	COG1309	transcriptional regulator
I3U38_RS24705	COG1028	Short-chain dehydrogenase reductase Sdr
I3U38_RS24720	COG0508	dehydrogenase complex catalyzes the overall conversion of
I3U38_RS24725	COG0022	dehydrogenase e1 component
I3U38_RS24740	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
I3U38_RS24745	COG2311	Membrane
I3U38_RS24810	COG0617	tRNA 3'-terminal CCA addition
I3U38_RS24830	COG1595	DNA-templated transcription, initiation
I3U38_RS24850	COG0860	N-Acetylmuramoyl-L-alanine amidase
I3U38_RS24850	COG3409	Peptidoglycan-binding domain 1 protein
I3U38_RS24860	COG2124	cytochrome p450
I3U38_RS24870	COG1309	transcriptional regulator
I3U38_RS24890	COG1192	Involved in chromosome partitioning
I3U38_RS24895	COG0357	Ribosomal RNA small subunit methyltransferase G
I3U38_RS24905	COG0706	membrane insertase activity
I3U38_RS24910	COG0759	Could be involved in insertion of integral membrane proteins into the membrane