locus-tag	class	description
I3U44_RS00015	COG0592	DNA-directed DNA polymerase activity
I3U44_RS00020	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
I3U44_RS00025	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I3U44_RS00030	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
I3U44_RS00035	COG0187	DNA topoisomerase II activity
I3U44_RS00120	COG2814	Major facilitator Superfamily
I3U44_RS00125	COG0583	DNA-binding transcription factor activity
I3U44_RS00140	COG0457	Tetratricopeptide repeat
I3U44_RS00140	COG0705	Rhomboid family
I3U44_RS00170	COG0515	serine threonine protein kinase
I3U44_RS00170	COG2815	serine threonine protein kinase
I3U44_RS00175	COG0515	serine threonine protein kinase
I3U44_RS00180	COG0768	penicillin binding
I3U44_RS00195	COG1716	ATPase activity
I3U44_RS00200	COG1716	ATPase activity
I3U44_RS00220	COG0754	glutathionylspermidine amidase activity
I3U44_RS00230	COG1309	transcriptional regulator
I3U44_RS00250	COG4842	Belongs to the WXG100 family
I3U44_RS00270	COG0590	tRNA wobble adenosine to inosine editing
I3U44_RS00280	COG0583	DNA-binding transcription factor activity
I3U44_RS00285	COG1643	Atp-dependent helicase
I3U44_RS00290	COG1028	Short-chain dehydrogenase reductase Sdr
I3U44_RS00310	COG4585	Histidine kinase
I3U44_RS00330	COG1960	acyl-CoA dehydrogenase activity
I3U44_RS00375	COG2072	flavoprotein involved in K transport
I3U44_RS00385	COG0346	lactoylglutathione lyase activity
I3U44_RS00390	COG1414	Transcriptional regulator
I3U44_RS00410	COG1053	succinate dehydrogenase
I3U44_RS00440	COG1785	Belongs to the alkaline phosphatase family
I3U44_RS00460	COG0067	glutamate synthase
I3U44_RS00460	COG0069	glutamate synthase activity
I3U44_RS00460	COG0070	glutamate synthase
I3U44_RS00520	COG1796	DNA polymerase
I3U44_RS00520	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I3U44_RS00530	COG2072	flavoprotein involved in K transport
I3U44_RS00540	COG2124	cytochrome p450
I3U44_RS00555	COG1024	Enoyl-CoA hydratase
I3U44_RS00585	COG2372	response to copper ion
I3U44_RS00635	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I3U44_RS00655	COG3447	MASE1 domain protein
I3U44_RS00655	COG5002	protein histidine kinase activity
I3U44_RS00655	COG5001	Diguanylate cyclase
I3U44_RS00665	COG1528	Iron-storage protein
I3U44_RS00670	COG1528	Iron-storage protein
I3U44_RS00675	COG1316	TRANSCRIPTIONal
I3U44_RS00700	COG0406	alpha-ribazole phosphatase activity
I3U44_RS00710	COG0028	Belongs to the TPP enzyme family
I3U44_RS00735	COG2072	flavoprotein involved in K transport
I3U44_RS00745	COG2072	flavoprotein involved in K transport
I3U44_RS00765	COG1285	pathogenesis
I3U44_RS00815	COG2146	nitrite reductase [NAD(P)H] activity
I3U44_RS00815	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I3U44_RS00825	COG4133	protoheme IX ABC transporter activity
I3U44_RS00830	COG2070	2-Nitropropane dioxygenase
I3U44_RS00840	COG0583	DNA-binding transcription factor activity
I3U44_RS00855	COG1028	Short-chain dehydrogenase reductase Sdr
I3U44_RS00860	COG0204	Acyl-transferase
I3U44_RS00870	COG0561	phosphatase activity
I3U44_RS00890	COG1216	Glycosyl transferase, family 2
I3U44_RS00895	COG0671	phosphoesterase, PA-phosphatase related
I3U44_RS00900	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I3U44_RS00905	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I3U44_RS00925	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
I3U44_RS00930	COG0318	PFAM AMP-dependent synthetase and ligase
I3U44_RS00935	COG3321	synthase
I3U44_RS00935	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
I3U44_RS00935	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I3U44_RS00940	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I3U44_RS00990	COG1028	Short-chain dehydrogenase reductase Sdr
I3U44_RS00995	COG0277	FAD linked oxidase domain protein
I3U44_RS01005	COG2376	Dihydroxyacetone kinase
I3U44_RS01010	COG2267	carboxylic ester hydrolase activity
I3U44_RS01015	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I3U44_RS01020	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I3U44_RS01035	COG0671	phosphoesterase, PA-phosphatase related
I3U44_RS01045	COG1216	Glycosyl transferase, family 2
I3U44_RS01115	COG2226	methyltransferase
I3U44_RS01130	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I3U44_RS01135	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I3U44_RS01205	COG1960	acyl-CoA dehydrogenase activity
I3U44_RS01220	COG1028	Short-chain dehydrogenase reductase Sdr
I3U44_RS01240	COG1174	glycine betaine transport
I3U44_RS01255	COG0287	Prephenate dehydrogenase
I3U44_RS01265	COG0590	tRNA wobble adenosine to inosine editing
I3U44_RS01290	COG0343	queuine tRNA-ribosyltransferase activity
I3U44_RS01295	COG2124	cytochrome p450
I3U44_RS01300	COG0765	amino acid transport
I3U44_RS01305	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I3U44_RS01310	COG1793	dna ligase
I3U44_RS01340	COG2271	Major facilitator Superfamily
I3U44_RS01345	COG2130	NADP-dependent
I3U44_RS01370	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I3U44_RS01395	COG1028	Short-chain dehydrogenase reductase Sdr
I3U44_RS01445	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I3U44_RS01470	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I3U44_RS01480	COG0148	phosphopyruvate hydratase activity
I3U44_RS01510	COG0860	N-Acetylmuramoyl-L-alanine amidase
I3U44_RS01535	COG1492	cobalamin metabolic process
I3U44_RS01560	COG1960	acyl-CoA dehydrogenase activity
I3U44_RS01575	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I3U44_RS01605	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I3U44_RS01625	COG1231	oxidoreductase activity
I3U44_RS01655	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I3U44_RS01665	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I3U44_RS01695	COG2070	2-Nitropropane dioxygenase
I3U44_RS01735	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I3U44_RS01740	COG2971	BadF BadG BcrA BcrD
I3U44_RS01745	COG2814	Major facilitator Superfamily
I3U44_RS01765	COG3572	ergothioneine biosynthetic process
I3U44_RS01770	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I3U44_RS01775	COG0121	glutamine amidotransferase
I3U44_RS01780	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
I3U44_RS01785	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I3U44_RS01815	COG2030	dehydratase
I3U44_RS01820	COG1028	Short-chain dehydrogenase reductase Sdr
I3U44_RS01825	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I3U44_RS01835	COG1695	Transcriptional regulator
I3U44_RS01845	COG0475	glutathione-regulated potassium exporter activity
I3U44_RS01845	COG0569	domain protein
I3U44_RS01865	COG0714	Associated with various cellular activities
I3U44_RS01910	COG0556	nucleotide-excision repair
I3U44_RS01920	COG3727	T/G mismatch-specific endonuclease activity
I3U44_RS01930	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I3U44_RS01935	COG1074	ATP-dependent DNA helicase activity
I3U44_RS01940	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I3U44_RS01950	COG2755	lipolytic protein G-D-S-L family
I3U44_RS01980	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I3U44_RS01985	COG1408	metallophosphoesterase
I3U44_RS01990	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I3U44_RS02020	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I3U44_RS02060	COG0596	Alpha beta hydrolase
I3U44_RS02060	COG2945	thiolester hydrolase activity
I3U44_RS02075	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I3U44_RS02080	COG0747	negative chemotaxis
I3U44_RS02090	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I3U44_RS02120	COG4974	Belongs to the 'phage' integrase family
I3U44_RS02150	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I3U44_RS02160	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
I3U44_RS02170	COG0667	Aldo Keto reductase
I3U44_RS02180	COG1595	DNA-templated transcription, initiation
I3U44_RS02185	COG2814	Major facilitator Superfamily
I3U44_RS02310	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I3U44_RS02315	COG1309	transcriptional regulator
I3U44_RS02320	COG0657	acetylesterase activity
I3U44_RS02325	COG1902	pentaerythritol trinitrate reductase activity
I3U44_RS02330	COG1111	helicase
I3U44_RS02330	COG1205	dead DEAH box helicase
I3U44_RS02335	COG1278	Cold shock
I3U44_RS02345	COG1754	DNA topoisomerase type I activity
I3U44_RS02345	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I3U44_RS02465	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I3U44_RS02500	COG2027	D-alanyl-D-alanine carboxypeptidase
I3U44_RS02535	COG1063	alcohol dehydrogenase
I3U44_RS02545	COG2267	carboxylic ester hydrolase activity
I3U44_RS02555	COG1309	transcriptional regulator
I3U44_RS02570	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I3U44_RS02615	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
I3U44_RS02625	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I3U44_RS02645	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
I3U44_RS02650	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I3U44_RS02690	COG4977	sequence-specific DNA binding
I3U44_RS02695	COG1194	a g-specific adenine glycosylase
I3U44_RS02705	COG1316	TRANSCRIPTIONal
I3U44_RS02715	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
I3U44_RS02725	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I3U44_RS02745	COG1329	Transcriptional regulator
I3U44_RS02750	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
I3U44_RS02760	COG0215	cysteine-tRNA ligase activity
I3U44_RS02770	COG0584	glycerophosphoryl diester phosphodiesterase
I3U44_RS02780	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I3U44_RS02785	COG1120	ATPase activity
I3U44_RS02790	COG0803	Belongs to the bacterial solute-binding protein 9 family
I3U44_RS02800	COG1309	transcriptional regulator
I3U44_RS02805	COG1960	acyl-CoA dehydrogenase activity
I3U44_RS02815	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I3U44_RS02825	COG0346	lactoylglutathione lyase activity
I3U44_RS02865	COG1960	acyl-CoA dehydrogenase activity
I3U44_RS02870	COG1960	acyl-CoA dehydrogenase activity
I3U44_RS02875	COG1960	acyl-CoA dehydrogenase activity
I3U44_RS02880	COG0318	PFAM AMP-dependent synthetase and ligase
I3U44_RS02885	COG1960	acyl-CoA dehydrogenase activity
I3U44_RS02900	COG0183	Belongs to the thiolase family
I3U44_RS02930	COG1024	Enoyl-CoA hydratase
I3U44_RS02935	COG1028	Short-chain dehydrogenase reductase Sdr
I3U44_RS02940	COG1028	Short-chain dehydrogenase reductase Sdr
I3U44_RS02960	COG0183	Belongs to the thiolase family
I3U44_RS02970	COG1960	acyl-CoA dehydrogenase activity
I3U44_RS02975	COG1960	acyl-CoA dehydrogenase activity
I3U44_RS02980	COG2030	dehydratase
I3U44_RS03005	COG2030	dehydratase
I3U44_RS03010	COG1053	succinate dehydrogenase
I3U44_RS03020	COG3971	2-oxopent-4-enoate hydratase activity
I3U44_RS03065	COG0651	ATP synthesis coupled electron transport
I3U44_RS03075	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I3U44_RS03075	COG2111	Na H antiporter
I3U44_RS03080	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I3U44_RS03100	COG0647	UMP catabolic process
I3U44_RS03135	COG4221	oxidoreductase activity
I3U44_RS03155	COG0459	protein refolding
I3U44_RS03170	COG0714	Associated with various cellular activities
I3U44_RS03235	COG4842	Belongs to the WXG100 family
I3U44_RS03280	COG0745	RESPONSE REGULATOR receiver
I3U44_RS03290	COG0537	adenosine 5'-monophosphoramidase activity
I3U44_RS03295	COG0697	spore germination
I3U44_RS03305	COG0596	Alpha beta hydrolase
I3U44_RS03335	COG0436	Aminotransferase
I3U44_RS03345	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I3U44_RS03370	COG0477	Major facilitator Superfamily
I3U44_RS03375	COG0386	Belongs to the glutathione peroxidase family
I3U44_RS03385	COG3573	Dehydrogenase
I3U44_RS03395	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I3U44_RS03410	COG2837	iron assimilation
I3U44_RS03415	COG1362	aminopeptidase activity
I3U44_RS03490	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I3U44_RS03500	COG0601	transmembrane transport
I3U44_RS03505	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I3U44_RS03510	COG4172	Belongs to the ABC transporter superfamily
I3U44_RS03540	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I3U44_RS03550	COG0354	folic acid binding
I3U44_RS03590	COG2897	thiosulfate sulfurtransferase activity
I3U44_RS03610	COG0745	RESPONSE REGULATOR receiver
I3U44_RS03630	COG0581	inorganic phosphate transmembrane transporter activity
I3U44_RS03635	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I3U44_RS03640	COG0604	alcohol dehydrogenase
I3U44_RS03695	COG1250	3-hydroxyacyl-CoA dehydrogenase
I3U44_RS03720	COG0697	spore germination
I3U44_RS03740	COG0442	prolyl-tRNA aminoacylation
I3U44_RS03745	COG2814	Major facilitator Superfamily
I3U44_RS03780	COG1674	ftsk spoiiie
I3U44_RS03905	COG5651	PPE family
I3U44_RS03910	COG0436	Aminotransferase
I3U44_RS03930	COG0531	amino acid
I3U44_RS03935	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
I3U44_RS03940	COG1012	belongs to the aldehyde dehydrogenase family
I3U44_RS03950	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I3U44_RS03955	COG2902	Dehydrogenase
I3U44_RS03960	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I3U44_RS03965	COG1960	acyl-CoA dehydrogenase activity
I3U44_RS03970	COG1012	belongs to the aldehyde dehydrogenase family
I3U44_RS03975	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I3U44_RS03985	COG0657	acetylesterase activity
I3U44_RS03990	COG1028	Short-chain dehydrogenase reductase Sdr
I3U44_RS04005	COG1028	Short-chain dehydrogenase reductase Sdr
I3U44_RS04020	COG1024	Enoyl-CoA hydratase
I3U44_RS04065	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I3U44_RS04070	COG0657	acetylesterase activity
I3U44_RS04090	COG0183	Belongs to the thiolase family
I3U44_RS04105	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I3U44_RS04125	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I3U44_RS04130	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3U44_RS04140	COG1061	Type III restriction enzyme res subunit
I3U44_RS04165	COG0521	Mo-molybdopterin cofactor biosynthetic process
I3U44_RS04175	COG2226	methyltransferase
I3U44_RS04180	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I3U44_RS04205	COG1278	Cold shock
I3U44_RS04245	COG2814	Major facilitator Superfamily
I3U44_RS04305	COG1764	response to oxidative stress
I3U44_RS04310	COG1846	Transcriptional regulator
I3U44_RS04315	COG1216	Glycosyl transferase, family 2
I3U44_RS04320	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I3U44_RS04320	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I3U44_RS04360	COG0318	PFAM AMP-dependent synthetase and ligase
I3U44_RS04365	COG5651	PPE family
I3U44_RS04370	COG2409	Drug exporters of the RND superfamily
I3U44_RS04395	COG4977	sequence-specific DNA binding
I3U44_RS04420	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3U44_RS04430	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I3U44_RS04450	COG2186	Transcriptional regulator
I3U44_RS04455	COG0545	Peptidyl-prolyl cis-trans isomerase
I3U44_RS04495	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I3U44_RS04500	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
I3U44_RS04545	COG1012	belongs to the aldehyde dehydrogenase family
I3U44_RS04560	COG3022	response to hydroperoxide
I3U44_RS04570	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I3U44_RS04605	COG1309	transcriptional regulator
I3U44_RS04635	COG1393	Belongs to the ArsC family
I3U44_RS04640	COG0583	DNA-binding transcription factor activity
I3U44_RS04680	COG0183	Belongs to the thiolase family
I3U44_RS04725	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I3U44_RS04765	COG0438	transferase activity, transferring glycosyl groups
I3U44_RS04770	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I3U44_RS04845	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
I3U44_RS04850	COG1846	Transcriptional regulator
I3U44_RS04900	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I3U44_RS04910	COG2326	polyphosphate kinase activity
I3U44_RS04925	COG2084	Dehydrogenase
I3U44_RS04940	COG0523	cobalamin synthesis protein
I3U44_RS04945	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I3U44_RS04950	COG0235	Class ii aldolase
I3U44_RS04955	COG1396	sequence-specific DNA binding
I3U44_RS04960	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I3U44_RS04960	COG0604	alcohol dehydrogenase
I3U44_RS04960	COG3321	synthase
I3U44_RS04960	COG4221	oxidoreductase activity
I3U44_RS04970	COG0166	Belongs to the GPI family
I3U44_RS05015	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3U44_RS05075	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I3U44_RS05105	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I3U44_RS05110	COG0521	Mo-molybdopterin cofactor biosynthetic process
I3U44_RS05110	COG0315	cyclic pyranopterin monophosphate synthase activity
I3U44_RS05145	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I3U44_RS05150	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I3U44_RS05195	COG1063	alcohol dehydrogenase
I3U44_RS05210	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I3U44_RS05245	COG2235	arginine
I3U44_RS05260	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I3U44_RS05275	COG1252	NADH dehydrogenase
I3U44_RS05285	COG0084	hydrolase, TatD family'
I3U44_RS05290	COG3583	domain protein
I3U44_RS05305	COG0515	serine threonine protein kinase
I3U44_RS05305	COG2815	serine threonine protein kinase
I3U44_RS05325	COG1846	Transcriptional regulator
I3U44_RS05325	COG0456	acetyltransferase
I3U44_RS05330	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I3U44_RS05335	COG0318	PFAM AMP-dependent synthetase and ligase
I3U44_RS05375	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I3U44_RS05410	COG1309	transcriptional regulator
I3U44_RS05455	COG3956	TIGRFAM MazG family protein
I3U44_RS05470	COG2837	iron assimilation
I3U44_RS05475	COG2822	iron ion transport
I3U44_RS05510	COG0596	Alpha beta hydrolase
I3U44_RS05535	COG0318	PFAM AMP-dependent synthetase and ligase
I3U44_RS05575	COG3179	chitinase
I3U44_RS05620	COG0427	acetyl-CoA hydrolase
I3U44_RS05670	COG1846	Transcriptional regulator
I3U44_RS05685	COG1024	Enoyl-CoA hydratase
I3U44_RS05710	COG0183	Belongs to the thiolase family
I3U44_RS05715	COG2755	lipolytic protein G-D-S-L family
I3U44_RS05720	COG0657	acetylesterase activity
I3U44_RS05730	COG1714	RDD family
I3U44_RS05745	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I3U44_RS05765	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I3U44_RS05775	COG1331	Highly conserved protein containing a thioredoxin domain
I3U44_RS05780	COG3631	Ketosteroid isomerase-related protein
I3U44_RS05795	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I3U44_RS05800	COG1028	Short-chain dehydrogenase reductase Sdr
I3U44_RS05805	COG2124	cytochrome p450
I3U44_RS05825	COG1028	Short-chain dehydrogenase reductase Sdr
I3U44_RS05865	COG2272	Belongs to the type-B carboxylesterase lipase family
I3U44_RS05875	COG1174	glycine betaine transport
I3U44_RS05880	COG0517	IMP dehydrogenase activity
I3U44_RS05880	COG1125	glycine betaine transport
I3U44_RS05885	COG1174	glycine betaine transport
I3U44_RS05930	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I3U44_RS05940	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
I3U44_RS05945	COG0726	polysaccharide deacetylase
I3U44_RS05950	COG2366	antibiotic biosynthetic process
I3U44_RS06020	COG1570	exodeoxyribonuclease VII activity
I3U44_RS06030	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I3U44_RS06045	COG1966	Carbon starvation protein
I3U44_RS06070	COG3189	MarR family transcriptional regulator
I3U44_RS06075	COG0012	GTP binding
I3U44_RS06090	COG2132	Multicopper oxidase
I3U44_RS06100	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I3U44_RS06110	COG0488	(ABC) transporter
I3U44_RS06165	COG2409	Drug exporters of the RND superfamily
I3U44_RS06200	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I3U44_RS06220	COG1716	ATPase activity
I3U44_RS06250	COG1051	belongs to the nudix hydrolase family
I3U44_RS06275	COG1217	gtp-binding protein TYPA
I3U44_RS06285	COG2015	COG2015, Alkyl sulfatase and related hydrolases
I3U44_RS06290	COG2207	Transcriptional regulator
I3U44_RS06290	COG1609	Transcriptional regulator
I3U44_RS06350	COG1902	pentaerythritol trinitrate reductase activity
I3U44_RS06350	COG0446	pyridine nucleotide-disulphide oxidoreductase
I3U44_RS06365	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
I3U44_RS06375	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I3U44_RS06380	COG1012	belongs to the aldehyde dehydrogenase family
I3U44_RS06385	COG0506	proline dehydrogenase activity
I3U44_RS06390	COG0318	PFAM AMP-dependent synthetase and ligase
I3U44_RS06415	COG2207	Transcriptional regulator
I3U44_RS06430	COG1611	Belongs to the LOG family
I3U44_RS06435	COG1611	Belongs to the LOG family
I3U44_RS06440	COG0318	PFAM AMP-dependent synthetase and ligase
I3U44_RS06450	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I3U44_RS06460	COG0463	Glycosyl transferase, family 2
I3U44_RS06475	COG0519	Catalyzes the synthesis of GMP from XMP
I3U44_RS06485	COG0297	glycogen (starch) synthase activity
I3U44_RS06500	COG3559	Exporter of polyketide antibiotics
I3U44_RS06505	COG1131	(ABC) transporter
I3U44_RS06510	COG1309	transcriptional regulator
I3U44_RS06520	COG1595	DNA-templated transcription, initiation
I3U44_RS06525	COG5662	AntiSigma factor
I3U44_RS06530	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I3U44_RS06600	COG0598	Magnesium transport protein CorA
I3U44_RS06605	COG2095	MarC family integral membrane protein
I3U44_RS06620	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I3U44_RS06625	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I3U44_RS06645	COG3835	regulator
I3U44_RS06650	COG1073	alpha beta
I3U44_RS06655	COG0567	Dehydrogenase, E1 component
I3U44_RS06655	COG0508	dehydrogenase complex catalyzes the overall conversion of
I3U44_RS06665	COG2814	Major facilitator Superfamily
I3U44_RS06725	COG0277	FAD linked oxidase domain protein
I3U44_RS06730	COG1028	Short-chain dehydrogenase reductase Sdr
I3U44_RS06745	COG0668	transmembrane transport
I3U44_RS06835	COG2814	Major facilitator Superfamily
I3U44_RS06865	COG0019	diaminopimelate decarboxylase activity
I3U44_RS06870	COG0460	homoserine dehydrogenase
I3U44_RS06875	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I3U44_RS06910	COG2890	protein-(glutamine-N5) methyltransferase activity
I3U44_RS06920	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I3U44_RS06930	COG0356	it plays a direct role in the translocation of protons across the membrane
I3U44_RS06935	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I3U44_RS06960	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I3U44_RS07020	COG0346	lactoylglutathione lyase activity
I3U44_RS07025	COG0183	Belongs to the thiolase family
I3U44_RS07030	COG2409	Drug exporters of the RND superfamily
I3U44_RS07045	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I3U44_RS07050	COG0366	Alpha amylase catalytic
I3U44_RS07055	COG0058	SHG alpha-glucan phosphorylase activity
I3U44_RS07070	COG1335	isochorismatase
I3U44_RS07080	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I3U44_RS07095	COG3191	aminopeptidase activity
I3U44_RS07140	COG0604	alcohol dehydrogenase
I3U44_RS07160	COG0318	PFAM AMP-dependent synthetase and ligase
I3U44_RS07175	COG0419	ATPase involved in DNA repair
I3U44_RS07180	COG1024	Enoyl-CoA hydratase
I3U44_RS07190	COG0243	molybdopterin cofactor binding
I3U44_RS07205	COG2188	Transcriptional regulator
I3U44_RS07265	COG0596	Alpha beta hydrolase
I3U44_RS07270	COG3757	hydrolase, family 25
I3U44_RS07285	COG1051	belongs to the nudix hydrolase family
I3U44_RS07305	COG1309	transcriptional regulator
I3U44_RS07320	COG4585	Histidine kinase
I3U44_RS07325	COG2197	response regulator
I3U44_RS07335	COG2239	Acts as a magnesium transporter
I3U44_RS07345	COG0300	oxidoreductase activity
I3U44_RS07355	COG0656	L-ascorbic acid biosynthetic process
I3U44_RS07375	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I3U44_RS07755	COG3179	chitinase
I3U44_RS07815	COG1376	ErfK ybiS ycfS ynhG family protein
I3U44_RS07905	COG0384	phenazine biosynthesis protein PhzF
I3U44_RS07995	COG0483	inositol monophosphate 1-phosphatase activity
I3U44_RS08035	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I3U44_RS08040	COG0433	COG0433 Predicted ATPase
I3U44_RS08055	COG0300	oxidoreductase activity
I3U44_RS08070	COG1301	dicarboxylic acid transport
I3U44_RS08080	COG0531	amino acid
I3U44_RS08100	COG4424	Sulfotransferase
I3U44_RS08105	COG3119	arylsulfatase activity
I3U44_RS08130	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I3U44_RS08130	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I3U44_RS08165	COG2902	Dehydrogenase
I3U44_RS08170	COG0824	Thioesterase
I3U44_RS08185	COG0366	Alpha amylase catalytic
I3U44_RS08220	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I3U44_RS08240	COG1309	transcriptional regulator
I3U44_RS08255	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
I3U44_RS08300	COG0740	serine-type endopeptidase activity
I3U44_RS08305	COG0740	serine-type endopeptidase activity
I3U44_RS08355	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I3U44_RS08365	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I3U44_RS08365	COG0674	pyruvate-flavodoxin oxidoreductase activity
I3U44_RS08370	COG1013	pyruvate-flavodoxin oxidoreductase activity
I3U44_RS08380	COG1388	LysM domain
I3U44_RS08410	COG0525	valine-tRNA ligase activity
I3U44_RS08415	COG0285	dihydrofolate synthase activity
I3U44_RS08430	COG1530	ribonuclease E activity
I3U44_RS08430	COG1530	ribonuclease E activity
I3U44_RS08460	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I3U44_RS08480	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I3U44_RS08485	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I3U44_RS08490	COG0542	response to heat
I3U44_RS08500	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I3U44_RS08510	COG0406	alpha-ribazole phosphatase activity
I3U44_RS08515	COG2755	lipolytic protein G-D-S-L family
I3U44_RS08535	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I3U44_RS08570	COG2308	Evidence 4 Homologs of previously reported genes of
I3U44_RS08580	COG1305	Transglutaminase-like
I3U44_RS08610	COG3387	PFAM Glycoside hydrolase 15-related
I3U44_RS08625	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I3U44_RS08660	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
I3U44_RS08665	COG4208	sulfate ABC transporter
I3U44_RS08720	COG0484	heat shock protein binding
I3U44_RS08770	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I3U44_RS08800	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I3U44_RS08815	COG0076	glutamate decarboxylase activity
I3U44_RS08850	COG0318	PFAM AMP-dependent synthetase and ligase
I3U44_RS08900	COG0423	glycine-tRNA ligase activity
I3U44_RS08905	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I3U44_RS08910	COG2515	1-aminocyclopropane-1-carboxylate deaminase
I3U44_RS08930	COG0358	DNA primase activity
I3U44_RS09000	COG0745	RESPONSE REGULATOR receiver
I3U44_RS09005	COG5002	protein histidine kinase activity
I3U44_RS09035	COG2267	carboxylic ester hydrolase activity
I3U44_RS09390	COG3179	chitinase
I3U44_RS09520	COG0488	(ABC) transporter
I3U44_RS09545	COG1960	acyl-CoA dehydrogenase activity
I3U44_RS09550	COG1335	isochorismatase
I3U44_RS09560	COG0058	SHG alpha-glucan phosphorylase activity
I3U44_RS09595	COG2267	carboxylic ester hydrolase activity
I3U44_RS09605	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I3U44_RS09610	COG1960	acyl-CoA dehydrogenase activity
I3U44_RS09615	COG0183	Belongs to the thiolase family
I3U44_RS09635	COG1228	amidohydrolase
I3U44_RS09675	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I3U44_RS09705	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I3U44_RS09750	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I3U44_RS09795	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
I3U44_RS09800	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
I3U44_RS09860	COG0714	Associated with various cellular activities
I3U44_RS09895	COG0318	PFAM AMP-dependent synthetase and ligase
I3U44_RS09920	COG0174	glutamine synthetase
I3U44_RS09925	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I3U44_RS09955	COG2205	protein histidine kinase activity
I3U44_RS09985	COG0174	glutamine synthetase
I3U44_RS09995	COG0477	Major facilitator Superfamily
I3U44_RS10005	COG3486	L-lysine 6-monooxygenase (NADPH) activity
I3U44_RS10025	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I3U44_RS10030	COG0321	lipoyl(octanoyl) transferase activity
I3U44_RS10045	COG1872	DUF167
I3U44_RS10065	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I3U44_RS10075	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
I3U44_RS10080	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
I3U44_RS10110	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I3U44_RS10155	COG2010	Cytochrome c
I3U44_RS10160	COG1845	cytochrome c oxidase, subunit III
I3U44_RS10165	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I3U44_RS10200	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I3U44_RS10225	COG0003	Pfam Anion-transporting ATPase
I3U44_RS10235	COG0204	Acyl-transferase
I3U44_RS10240	COG5650	phosphatidylinositol metabolic process
I3U44_RS10250	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
I3U44_RS10275	COG0142	geranyltranstransferase activity
I3U44_RS10315	COG0768	penicillin binding
I3U44_RS10335	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I3U44_RS10345	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I3U44_RS10360	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I3U44_RS10385	COG0640	Transcriptional regulator
I3U44_RS10435	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I3U44_RS10445	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I3U44_RS10455	COG1028	Short-chain dehydrogenase reductase Sdr
I3U44_RS10485	COG2814	Major facilitator Superfamily
I3U44_RS10500	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I3U44_RS10530	COG1968	undecaprenyl-diphosphatase activity
I3U44_RS10565	COG1218	3'(2'),5'-bisphosphate nucleotidase
I3U44_RS10575	COG1028	Short-chain dehydrogenase reductase Sdr
I3U44_RS10600	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I3U44_RS10610	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I3U44_RS10610	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
I3U44_RS10625	COG2860	membrane
I3U44_RS10640	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I3U44_RS10650	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I3U44_RS10685	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
I3U44_RS10690	COG1034	ATP synthesis coupled electron transport
I3U44_RS10695	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
I3U44_RS10700	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I3U44_RS10780	COG0513	Belongs to the DEAD box helicase family
I3U44_RS10815	COG0028	Belongs to the TPP enzyme family
I3U44_RS10830	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I3U44_RS10835	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
I3U44_RS10840	COG4122	O-methyltransferase activity
I3U44_RS10870	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I3U44_RS10875	COG4521	taurine ABC transporter
I3U44_RS10880	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
I3U44_RS10920	COG2378	regulation of single-species biofilm formation
I3U44_RS10925	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I3U44_RS10960	COG0300	oxidoreductase activity
I3U44_RS11015	COG1574	metal-dependent hydrolase with the TIM-barrel fold
I3U44_RS11025	COG0463	Glycosyl transferase, family 2
I3U44_RS11075	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I3U44_RS11085	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I3U44_RS11090	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3U44_RS11110	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
I3U44_RS11120	COG1404	Belongs to the peptidase S8 family
I3U44_RS11135	COG4842	Belongs to the WXG100 family
I3U44_RS11165	COG0464	growth
I3U44_RS11185	COG0583	DNA-binding transcription factor activity
I3U44_RS11215	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I3U44_RS11220	COG1169	isochorismate synthase
I3U44_RS11225	COG0789	Transcriptional regulator
I3U44_RS11230	COG1021	2,3-dihydroxybenzoate-AMP ligase
I3U44_RS11260	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
I3U44_RS11285	COG1028	Short-chain dehydrogenase reductase Sdr
I3U44_RS11285	COG0300	oxidoreductase activity
I3U44_RS11285	COG0318	PFAM AMP-dependent synthetase and ligase
I3U44_RS11285	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I3U44_RS11285	COG3321	synthase
I3U44_RS11300	COG1132	(ABC) transporter
I3U44_RS11305	COG1132	(ABC) transporter
I3U44_RS11305	COG2375	cellular response to nickel ion
I3U44_RS11310	COG0477	Major facilitator Superfamily
I3U44_RS11315	COG5285	phytanoyl-CoA dioxygenase
I3U44_RS11325	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I3U44_RS11330	COG0456	acetyltransferase
I3U44_RS11345	COG2837	iron assimilation
I3U44_RS11355	COG2186	Transcriptional regulator
I3U44_RS11360	COG2807	transmembrane transport
I3U44_RS11370	COG2409	Drug exporters of the RND superfamily
I3U44_RS11375	COG3629	intracellular signal transduction
I3U44_RS11380	COG1012	belongs to the aldehyde dehydrogenase family
I3U44_RS11420	COG0475	glutathione-regulated potassium exporter activity
I3U44_RS11485	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I3U44_RS11490	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I3U44_RS11490	COG0237	dephospho-CoA kinase activity
I3U44_RS11665	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I3U44_RS11670	COG0072	phenylalanine-tRNA ligase activity
I3U44_RS11670	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I3U44_RS11680	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I3U44_RS11685	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I3U44_RS11690	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I3U44_RS11695	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I3U44_RS11700	COG1438	arginine binding
I3U44_RS11705	COG0137	argininosuccinate synthase activity
I3U44_RS11745	COG2835	tetraacyldisaccharide 4'-kinase activity
I3U44_RS11750	COG1309	transcriptional regulator
I3U44_RS11755	COG2094	Belongs to the DNA glycosylase MPG family
I3U44_RS11770	COG0488	(ABC) transporter
I3U44_RS11780	COG0647	UMP catabolic process
I3U44_RS11795	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I3U44_RS11815	COG0504	CTP synthase activity
I3U44_RS11820	COG0494	nUDIX hydrolase
I3U44_RS11840	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I3U44_RS11855	COG1160	GTP binding
I3U44_RS11865	COG1403	HNH endonuclease
I3U44_RS11905	COG1053	succinate dehydrogenase
I3U44_RS11935	COG1960	acyl-CoA dehydrogenase activity
I3U44_RS11990	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I3U44_RS11990	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I3U44_RS12005	COG1253	flavin adenine dinucleotide binding
I3U44_RS12010	COG1253	flavin adenine dinucleotide binding
I3U44_RS12020	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I3U44_RS12075	COG0832	Belongs to the urease beta subunit family
I3U44_RS12085	COG0830	nickel cation binding
I3U44_RS12100	COG1252	NADH dehydrogenase
I3U44_RS12110	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3U44_RS12145	COG0243	molybdopterin cofactor binding
I3U44_RS12155	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I3U44_RS12170	COG1058	Belongs to the CinA family
I3U44_RS12170	COG1546	Belongs to the CinA family
I3U44_RS12180	COG4977	sequence-specific DNA binding
I3U44_RS12185	COG1741	Belongs to the pirin family
I3U44_RS12205	COG1968	undecaprenyl-diphosphatase activity
I3U44_RS12210	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
I3U44_RS12235	COG0277	FAD linked oxidase domain protein
I3U44_RS12245	COG1309	transcriptional regulator
I3U44_RS12260	COG1116	anion transmembrane transporter activity
I3U44_RS12265	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I3U44_RS12295	COG4290	ribonuclease
I3U44_RS12325	COG0791	NLP P60 protein
I3U44_RS12325	COG3883	PFAM NLP P60 protein
I3U44_RS12360	COG0477	Major facilitator Superfamily
I3U44_RS12380	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I3U44_RS12385	COG0067	glutamate synthase
I3U44_RS12385	COG0069	glutamate synthase activity
I3U44_RS12385	COG0070	glutamate synthase
I3U44_RS12410	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I3U44_RS12425	COG1960	acyl-CoA dehydrogenase activity
I3U44_RS12440	COG0443	Heat shock 70 kDa protein
I3U44_RS12445	COG0596	Alpha beta hydrolase
I3U44_RS12465	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I3U44_RS12475	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
I3U44_RS12500	COG2890	protein-(glutamine-N5) methyltransferase activity
I3U44_RS12570	COG1982	Orn Lys Arg decarboxylase major
I3U44_RS12630	COG0028	Belongs to the TPP enzyme family
I3U44_RS12660	COG1309	transcriptional regulator
I3U44_RS12665	COG2957	Belongs to the agmatine deiminase family
I3U44_RS12670	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I3U44_RS12685	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I3U44_RS12745	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
I3U44_RS12760	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
I3U44_RS12780	COG0640	Transcriptional regulator
I3U44_RS12790	COG0798	PFAM Bile acid sodium symporter
I3U44_RS12795	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I3U44_RS12800	COG0390	transport system, permease component
I3U44_RS12820	COG0318	PFAM AMP-dependent synthetase and ligase
I3U44_RS12825	COG0179	Fumarylacetoacetate (FAA) hydrolase
I3U44_RS12900	COG2124	cytochrome p450
I3U44_RS12915	COG1063	alcohol dehydrogenase
I3U44_RS12940	COG4638	Rieske (2fe-2S)
I3U44_RS12965	COG4221	oxidoreductase activity
I3U44_RS12980	COG2124	cytochrome p450
I3U44_RS13010	COG4221	oxidoreductase activity
I3U44_RS13015	COG0657	acetylesterase activity
I3U44_RS13070	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I3U44_RS13105	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I3U44_RS13125	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I3U44_RS13175	COG1028	Short-chain dehydrogenase reductase Sdr
I3U44_RS13180	COG3618	amidohydrolase
I3U44_RS13255	COG1960	acyl-CoA dehydrogenase activity
I3U44_RS13260	COG1960	acyl-CoA dehydrogenase activity
I3U44_RS13265	COG1960	acyl-CoA dehydrogenase activity
I3U44_RS13290	COG1012	belongs to the aldehyde dehydrogenase family
I3U44_RS13345	COG0300	oxidoreductase activity
I3U44_RS13360	COG2267	carboxylic ester hydrolase activity
I3U44_RS13380	COG1024	Enoyl-CoA hydratase
I3U44_RS13385	COG0318	PFAM AMP-dependent synthetase and ligase
I3U44_RS13420	COG1846	Transcriptional regulator
I3U44_RS13435	COG0038	chloride channel
I3U44_RS13490	COG0745	RESPONSE REGULATOR receiver
I3U44_RS13495	COG2205	protein histidine kinase activity
I3U44_RS13510	COG1917	Cupin 2, conserved barrel domain protein
I3U44_RS13515	COG3707	response regulator
I3U44_RS13555	COG3467	pyridoxamine 5'-phosphate
I3U44_RS13580	COG0640	Transcriptional regulator
I3U44_RS13600	COG1309	transcriptional regulator
I3U44_RS13605	COG2072	flavoprotein involved in K transport
I3U44_RS13615	COG0318	PFAM AMP-dependent synthetase and ligase
I3U44_RS13620	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I3U44_RS13625	COG0561	phosphatase activity
I3U44_RS13630	COG0673	inositol 2-dehydrogenase activity
I3U44_RS13635	COG0738	Major facilitator superfamily
I3U44_RS13725	COG1271	oxidase subunit
I3U44_RS13730	COG1294	oxidase, subunit
I3U44_RS13735	COG4988	ABC transporter
I3U44_RS13740	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I3U44_RS13765	COG1946	Acyl-CoA thioesterase
I3U44_RS13810	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I3U44_RS13820	COG1846	Transcriptional regulator
I3U44_RS13855	COG0483	inositol monophosphate 1-phosphatase activity
I3U44_RS13865	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I3U44_RS13870	COG0131	Imidazoleglycerol-phosphate dehydratase
I3U44_RS13875	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I3U44_RS13900	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I3U44_RS13915	COG1309	transcriptional regulator
I3U44_RS13930	COG0583	DNA-binding transcription factor activity
I3U44_RS13935	COG0579	oxidoreductase
I3U44_RS13975	COG2755	lipolytic protein G-D-S-L family
I3U44_RS13975	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I3U44_RS14030	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I3U44_RS14045	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I3U44_RS14050	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I3U44_RS14055	COG2814	Major facilitator Superfamily
I3U44_RS14060	COG0583	DNA-binding transcription factor activity
I3U44_RS14110	COG1914	H( )-stimulated, divalent metal cation uptake system
I3U44_RS14115	COG2239	Acts as a magnesium transporter
I3U44_RS14145	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I3U44_RS14155	COG2304	oxidoreductase activity
I3U44_RS14165	COG0714	Associated with various cellular activities
I3U44_RS14175	COG0791	NLP P60 protein
I3U44_RS14175	COG3883	PFAM NLP P60 protein
I3U44_RS14185	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I3U44_RS14190	COG1309	transcriptional regulator
I3U44_RS14215	COG0488	(ABC) transporter
I3U44_RS14230	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I3U44_RS14245	COG0456	acetyltransferase
I3U44_RS14255	COG2151	metal-sulfur cluster biosynthetic enzyme
I3U44_RS14270	COG0396	ATPase activity
I3U44_RS14295	COG1131	(ABC) transporter
I3U44_RS14335	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I3U44_RS14410	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I3U44_RS14470	COG0531	amino acid
I3U44_RS14525	COG2011	ABC-type metal ion transport system permease component
I3U44_RS14530	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I3U44_RS14550	COG0477	Major facilitator Superfamily
I3U44_RS14585	COG0657	acetylesterase activity
I3U44_RS14590	COG1953	Uracil, thiamine, allantoin
I3U44_RS14600	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I3U44_RS14615	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I3U44_RS14625	COG1758	RNA polymerase activity
I3U44_RS14645	COG0284	orotidine-5'-phosphate decarboxylase activity
I3U44_RS14650	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I3U44_RS14655	COG0505	Belongs to the CarA family
I3U44_RS14675	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
I3U44_RS14695	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I3U44_RS14705	COG0006	proline dipeptidase activity
I3U44_RS14720	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I3U44_RS14725	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I3U44_RS14740	COG4106	trans-aconitate 2-methyltransferase activity
I3U44_RS14755	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I3U44_RS14770	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I3U44_RS14835	COG0701	Predicted permease
I3U44_RS14860	COG2272	Belongs to the type-B carboxylesterase lipase family
I3U44_RS14900	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I3U44_RS14925	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I3U44_RS14935	COG0747	negative chemotaxis
I3U44_RS14940	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I3U44_RS14955	COG2255	four-way junction helicase activity
I3U44_RS14965	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
I3U44_RS15000	COG1946	Acyl-CoA thioesterase
I3U44_RS15005	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
I3U44_RS15020	COG0438	transferase activity, transferring glycosyl groups
I3U44_RS15060	COG4762	Protein conserved in bacteria
I3U44_RS15080	COG1228	amidohydrolase
I3U44_RS15110	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I3U44_RS15130	COG3878	Protein conserved in bacteria
I3U44_RS15145	COG1278	Cold shock
I3U44_RS15180	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I3U44_RS15200	COG0477	Major facilitator Superfamily
I3U44_RS15205	COG2020	methyltransferase activity
I3U44_RS15220	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I3U44_RS15220	COG2080	2 iron, 2 sulfur cluster binding
I3U44_RS15235	COG0402	S-adenosylhomocysteine deaminase activity
I3U44_RS15255	COG2233	PERMEase
I3U44_RS15275	COG1953	Uracil, thiamine, allantoin
I3U44_RS15285	COG1301	dicarboxylic acid transport
I3U44_RS15295	COG4266	Belongs to the allantoicase family
I3U44_RS15320	COG0501	Belongs to the peptidase M48B family
I3U44_RS15335	COG0477	Major facilitator Superfamily
I3U44_RS15390	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I3U44_RS15440	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I3U44_RS15460	COG3253	May function as heme-dependent peroxidase
I3U44_RS15465	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
I3U44_RS15470	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I3U44_RS15480	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
I3U44_RS15495	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I3U44_RS15500	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I3U44_RS15505	COG0531	amino acid
I3U44_RS15510	COG0569	domain protein
I3U44_RS15540	COG0702	epimerase
I3U44_RS15555	COG0756	dUTP diphosphatase activity
I3U44_RS15600	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I3U44_RS15650	COG3220	belongs to the UPF0276 family
I3U44_RS15725	COG1388	LysM domain
I3U44_RS15740	COG1960	acyl-CoA dehydrogenase activity
I3U44_RS15750	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I3U44_RS15770	COG1196	nuclear chromosome segregation
I3U44_RS15790	COG1126	abc transporter atp-binding protein
I3U44_RS15795	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I3U44_RS15800	COG0765	amino acid transport
I3U44_RS15805	COG0765	amino acid transport
I3U44_RS15855	COG4308	Limonene-1,2-epoxide hydrolase catalytic domain
I3U44_RS15860	COG4308	Limonene-1,2-epoxide hydrolase catalytic domain
I3U44_RS15875	COG1842	Phage shock protein A
I3U44_RS15880	COG1396	sequence-specific DNA binding
I3U44_RS15900	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I3U44_RS15955	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I3U44_RS15960	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I3U44_RS15975	COG3214	Protein conserved in bacteria
I3U44_RS16015	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I3U44_RS16025	COG0659	secondary active sulfate transmembrane transporter activity
I3U44_RS16035	COG0686	Belongs to the AlaDH PNT family
I3U44_RS16050	COG1028	Short-chain dehydrogenase reductase Sdr
I3U44_RS16100	COG2977	Belongs to the P-Pant transferase superfamily
I3U44_RS16105	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I3U44_RS16125	COG1960	acyl-CoA dehydrogenase activity
I3U44_RS16130	COG1960	acyl-CoA dehydrogenase activity
I3U44_RS16135	COG1024	Enoyl-CoA hydratase
I3U44_RS16160	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I3U44_RS16185	COG1017	nitric oxide dioxygenase activity
I3U44_RS16185	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I3U44_RS16190	COG1959	2 iron, 2 sulfur cluster binding
I3U44_RS16235	COG1648	precorrin-2 dehydrogenase activity
I3U44_RS16235	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I3U44_RS16260	COG3321	synthase
I3U44_RS16260	COG1028	Short-chain dehydrogenase reductase Sdr
I3U44_RS16260	COG0604	alcohol dehydrogenase
I3U44_RS16320	COG0579	oxidoreductase
I3U44_RS16340	COG1492	cobalamin metabolic process
I3U44_RS16350	COG1376	ErfK ybiS ycfS ynhG family protein
I3U44_RS16375	COG0750	zinc metalloprotease
I3U44_RS16400	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I3U44_RS16465	COG0528	UMP kinase activity
I3U44_RS16470	COG3973	AAA domain
I3U44_RS16475	COG3201	nicotinamide mononucleotide transporter
I3U44_RS16485	COG2723	6-phospho-beta-galactosidase activity
I3U44_RS16520	COG1309	transcriptional regulator
I3U44_RS16560	COG0583	DNA-binding transcription factor activity
I3U44_RS16725	COG0792	nuclease activity
I3U44_RS16735	COG2124	cytochrome p450
I3U44_RS16805	COG0336	Belongs to the RNA methyltransferase TrmD family
I3U44_RS16845	COG1686	Belongs to the peptidase S11 family
I3U44_RS16865	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I3U44_RS16885	COG1304	FMN binding
I3U44_RS16910	COG1254	Belongs to the acylphosphatase family
I3U44_RS16935	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
I3U44_RS16940	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
I3U44_RS16960	COG0571	ribonuclease III activity
I3U44_RS16970	COG3599	regulation of cell shape
I3U44_RS17145	COG0537	adenosine 5'-monophosphoramidase activity
I3U44_RS17235	COG0742	ribosomal rna small subunit methyltransferase
I3U44_RS17240	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
I3U44_RS17255	COG0657	acetylesterase activity
I3U44_RS17260	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3U44_RS17280	COG2124	cytochrome p450
I3U44_RS17295	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I3U44_RS17300	COG1461	Dihydroxyacetone kinase
I3U44_RS17310	COG1024	Enoyl-CoA hydratase
I3U44_RS17335	COG1181	Belongs to the D-alanine--D-alanine ligase family
I3U44_RS17340	COG0626	cystathionine gamma-synthase activity
I3U44_RS17345	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I3U44_RS17360	COG0406	alpha-ribazole phosphatase activity
I3U44_RS17360	COG0494	nUDIX hydrolase
I3U44_RS17410	COG0179	Fumarylacetoacetate (FAA) hydrolase
I3U44_RS17425	COG2271	Major facilitator Superfamily
I3U44_RS17460	COG0583	DNA-binding transcription factor activity
I3U44_RS17470	COG0778	Nitroreductase
I3U44_RS17485	COG1309	transcriptional regulator
I3U44_RS17490	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I3U44_RS17495	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I3U44_RS17500	COG2124	cytochrome p450
I3U44_RS17530	COG0440	acetolactate synthase activity
I3U44_RS17545	COG1748	Saccharopine dehydrogenase
I3U44_RS17550	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I3U44_RS17570	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I3U44_RS17590	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I3U44_RS17600	COG2272	Belongs to the type-B carboxylesterase lipase family
I3U44_RS17615	COG0745	RESPONSE REGULATOR receiver
I3U44_RS17620	COG2205	protein histidine kinase activity
I3U44_RS17645	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I3U44_RS17675	COG1024	Enoyl-CoA hydratase
I3U44_RS17680	COG0778	Nitroreductase
I3U44_RS17690	COG2252	PERMEase
I3U44_RS17745	COG2197	response regulator
I3U44_RS17750	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I3U44_RS17760	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I3U44_RS17785	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I3U44_RS17830	COG0110	maltose O-acetyltransferase activity
I3U44_RS17835	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I3U44_RS17860	COG1119	ATPase activity
I3U44_RS17870	COG2364	Membrane
I3U44_RS17875	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I3U44_RS17890	COG4607	ABC-type enterochelin transport system periplasmic component
I3U44_RS17940	COG1064	alcohol dehydrogenase
I3U44_RS17960	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I3U44_RS17965	COG1028	Short-chain dehydrogenase reductase Sdr
I3U44_RS18035	COG0477	Major facilitator Superfamily
I3U44_RS18055	COG1028	Short-chain dehydrogenase reductase Sdr
I3U44_RS18085	COG1028	Short-chain dehydrogenase reductase Sdr
I3U44_RS18110	COG1335	isochorismatase
I3U44_RS18120	COG2855	membrane
I3U44_RS18130	COG0318	PFAM AMP-dependent synthetase and ligase
I3U44_RS18145	COG1028	Short-chain dehydrogenase reductase Sdr
I3U44_RS18155	COG1028	Short-chain dehydrogenase reductase Sdr
I3U44_RS18160	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I3U44_RS18235	COG0183	Belongs to the thiolase family
I3U44_RS18270	COG1309	transcriptional regulator
I3U44_RS18300	COG0789	Transcriptional regulator
I3U44_RS18310	COG0028	Belongs to the TPP enzyme family
I3U44_RS18335	COG2177	Part of the ABC transporter FtsEX involved in
I3U44_RS18340	COG2884	Cell division ATP-binding protein ftsE
I3U44_RS18350	COG0668	transmembrane transport
I3U44_RS18390	COG0483	inositol monophosphate 1-phosphatase activity
I3U44_RS18395	COG1960	acyl-CoA dehydrogenase activity
I3U44_RS18400	COG1960	acyl-CoA dehydrogenase activity
I3U44_RS18415	COG0318	PFAM AMP-dependent synthetase and ligase
I3U44_RS18425	COG0542	response to heat
I3U44_RS18485	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
I3U44_RS18660	COG0454	-acetyltransferase
I3U44_RS18885	COG3480	Lon protease (S16) C-terminal proteolytic domain
I3U44_RS18890	COG3011	Protein conserved in bacteria
I3U44_RS18905	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I3U44_RS18910	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I3U44_RS18915	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I3U44_RS18950	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I3U44_RS18950	COG0475	glutathione-regulated potassium exporter activity
I3U44_RS18960	COG0210	DNA helicase
I3U44_RS18965	COG0596	Alpha beta hydrolase
I3U44_RS18980	COG0745	RESPONSE REGULATOR receiver
I3U44_RS18990	COG2146	nitrite reductase [NAD(P)H] activity
I3U44_RS18990	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I3U44_RS18995	COG2223	nitrite transmembrane transporter activity
I3U44_RS19035	COG0513	Belongs to the DEAD box helicase family
I3U44_RS19050	COG0406	alpha-ribazole phosphatase activity
I3U44_RS19070	COG1597	lipid kinase activity
I3U44_RS19085	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
I3U44_RS19100	COG1595	DNA-templated transcription, initiation
I3U44_RS19105	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I3U44_RS19110	COG2135	peptidase activity
I3U44_RS19115	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I3U44_RS19120	COG1162	GTPase activity
I3U44_RS19155	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I3U44_RS19250	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I3U44_RS19255	COG0604	alcohol dehydrogenase
I3U44_RS19255	COG3321	synthase
I3U44_RS19260	COG0604	alcohol dehydrogenase
I3U44_RS19260	COG3321	synthase
I3U44_RS19265	COG1960	acyl-CoA dehydrogenase activity
I3U44_RS19275	COG0318	PFAM AMP-dependent synthetase and ligase
I3U44_RS19280	COG0653	protein targeting
I3U44_RS19290	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I3U44_RS19295	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I3U44_RS19305	COG1309	transcriptional regulator
I3U44_RS19320	COG5401	PFAM Sporulation and spore germination
I3U44_RS19325	COG5002	protein histidine kinase activity
I3U44_RS19335	COG0318	PFAM AMP-dependent synthetase and ligase
I3U44_RS19340	COG1285	pathogenesis
I3U44_RS19370	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I3U44_RS19375	COG0531	amino acid
I3U44_RS19385	COG1482	cell wall glycoprotein biosynthetic process
I3U44_RS19415	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I3U44_RS19420	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
I3U44_RS19420	COG0778	Nitroreductase
I3U44_RS19435	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I3U44_RS19450	COG1316	TRANSCRIPTIONal
I3U44_RS19470	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I3U44_RS19480	COG2175	clavaminate synthase activity
I3U44_RS19505	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
I3U44_RS19505	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
I3U44_RS19515	COG0318	PFAM AMP-dependent synthetase and ligase
I3U44_RS19530	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I3U44_RS19550	COG3265	gluconokinase activity
I3U44_RS19555	COG1960	acyl-CoA dehydrogenase activity
I3U44_RS19570	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3U44_RS19590	COG4770	biotin carboxylase activity
I3U44_RS19620	COG1012	belongs to the aldehyde dehydrogenase family
I3U44_RS19625	COG1309	transcriptional regulator
I3U44_RS19630	COG1201	RNA secondary structure unwinding
I3U44_RS19665	COG1473	amidohydrolase
I3U44_RS19665	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
I3U44_RS19680	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I3U44_RS19695	COG0791	NLP P60 protein
I3U44_RS19695	COG3883	PFAM NLP P60 protein
I3U44_RS19740	COG2009	succinate dehydrogenase
I3U44_RS19755	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I3U44_RS19760	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I3U44_RS19765	COG1595	DNA-templated transcription, initiation
I3U44_RS19775	COG1686	Belongs to the peptidase S11 family
I3U44_RS19790	COG0708	Exodeoxyribonuclease III
I3U44_RS19850	COG1733	regulation of RNA biosynthetic process
I3U44_RS19855	COG2910	NAD(P)H-binding
I3U44_RS19860	COG1716	ATPase activity
I3U44_RS19860	COG0842	Transport permease protein
I3U44_RS19860	COG1131	(ABC) transporter
I3U44_RS19865	COG1357	PFAM Pentapeptide repeats (8 copies)
I3U44_RS19880	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I3U44_RS19890	COG1073	alpha beta
I3U44_RS19895	COG1309	transcriptional regulator
I3U44_RS19965	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I3U44_RS19965	COG0519	Catalyzes the synthesis of GMP from XMP
I3U44_RS19975	COG0516	GMP reductase activity
I3U44_RS20020	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I3U44_RS20035	COG0456	acetyltransferase
I3U44_RS20060	COG0076	glutamate decarboxylase activity
I3U44_RS20070	COG2267	carboxylic ester hydrolase activity
I3U44_RS20075	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I3U44_RS20100	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3U44_RS20110	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I3U44_RS20115	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I3U44_RS20150	COG1404	Belongs to the peptidase S8 family
I3U44_RS20180	COG2267	carboxylic ester hydrolase activity
I3U44_RS20235	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I3U44_RS20240	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I3U44_RS20250	COG2268	Band 7 protein
I3U44_RS20260	COG1088	dTDP-glucose 4,6-dehydratase activity
I3U44_RS20265	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
I3U44_RS20310	COG0616	signal peptide processing
I3U44_RS20325	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3U44_RS20345	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I3U44_RS20355	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I3U44_RS20365	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I3U44_RS20380	COG2272	Belongs to the type-B carboxylesterase lipase family
I3U44_RS20405	COG0477	Major facilitator Superfamily
I3U44_RS20415	COG2267	carboxylic ester hydrolase activity
I3U44_RS20420	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I3U44_RS20460	COG0088	Forms part of the polypeptide exit tunnel
I3U44_RS20465	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I3U44_RS20470	COG0051	transcription antitermination factor activity, RNA binding
I3U44_RS20505	COG0531	amino acid
I3U44_RS20535	COG0535	radical SAM domain protein
I3U44_RS20560	COG1834	amidinotransferase
I3U44_RS20565	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I3U44_RS20570	COG0531	amino acid
I3U44_RS20615	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I3U44_RS20620	COG1309	transcriptional regulator
I3U44_RS20645	COG1024	Enoyl-CoA hydratase
I3U44_RS20660	COG1960	acyl-CoA dehydrogenase activity
I3U44_RS20690	COG1113	amino acid transport
I3U44_RS20705	COG0085	RNA polymerase activity
I3U44_RS20710	COG0243	molybdopterin cofactor binding
I3U44_RS20765	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I3U44_RS20780	COG0277	FAD linked oxidase domain protein
I3U44_RS20800	COG4941	Belongs to the sigma-70 factor family
I3U44_RS20835	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I3U44_RS20875	COG0783	Belongs to the Dps family
I3U44_RS20880	COG0693	protein deglycase activity
I3U44_RS20925	COG1404	Belongs to the peptidase S8 family
I3U44_RS20945	COG1280	lysine exporter protein (LysE YggA)
I3U44_RS21015	COG0501	Belongs to the peptidase M48B family
I3U44_RS21020	COG0142	geranyltranstransferase activity
I3U44_RS21025	COG0644	oxidoreductase
I3U44_RS21035	COG0438	transferase activity, transferring glycosyl groups
I3U44_RS21055	COG4948	Mandelate Racemase Muconate Lactonizing
I3U44_RS21080	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I3U44_RS21085	COG0494	nUDIX hydrolase
I3U44_RS21105	COG0300	oxidoreductase activity
I3U44_RS21115	COG0318	PFAM AMP-dependent synthetase and ligase
I3U44_RS21120	COG1012	belongs to the aldehyde dehydrogenase family
I3U44_RS21165	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I3U44_RS21170	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I3U44_RS21175	COG0183	Belongs to the thiolase family
I3U44_RS21245	COG3706	GGDEF domain
I3U44_RS21260	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I3U44_RS21270	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I3U44_RS21275	COG1028	Short-chain dehydrogenase reductase Sdr
I3U44_RS21470	COG0740	serine-type endopeptidase activity
I3U44_RS21620	COG4974	Belongs to the 'phage' integrase family
I3U44_RS21625	COG4221	oxidoreductase activity
I3U44_RS21675	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
I3U44_RS21680	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I3U44_RS21720	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I3U44_RS21765	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I3U44_RS21770	COG1333	cytochrome c biogenesis protein
I3U44_RS21775	COG0785	Cytochrome C biogenesis protein
I3U44_RS21780	COG0386	Belongs to the glutathione peroxidase family
I3U44_RS21785	COG0406	alpha-ribazole phosphatase activity
I3U44_RS21805	COG3590	peptidase
I3U44_RS21855	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I3U44_RS21855	COG1587	Uroporphyrinogen-III synthase
I3U44_RS21880	COG2030	dehydratase
I3U44_RS21905	COG2070	2-Nitropropane dioxygenase
I3U44_RS21935	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I3U44_RS21945	COG3179	chitinase
I3U44_RS22020	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I3U44_RS22075	COG1309	transcriptional regulator
I3U44_RS22085	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I3U44_RS22135	COG2072	flavoprotein involved in K transport
I3U44_RS22150	COG2072	flavoprotein involved in K transport
I3U44_RS22155	COG1028	Short-chain dehydrogenase reductase Sdr
I3U44_RS22160	COG0657	acetylesterase activity
I3U44_RS22165	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I3U44_RS22175	COG0745	RESPONSE REGULATOR receiver
I3U44_RS22180	COG5002	protein histidine kinase activity
I3U44_RS22190	COG2072	flavoprotein involved in K transport
I3U44_RS22265	COG2814	Major facilitator Superfamily
I3U44_RS22270	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I3U44_RS22365	COG2733	membrane
I3U44_RS22375	COG2326	polyphosphate kinase activity
I3U44_RS22380	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I3U44_RS22415	COG2224	Isocitrate lyase
I3U44_RS22460	COG2226	methyltransferase
I3U44_RS22510	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I3U44_RS22545	COG0667	Aldo Keto reductase
I3U44_RS22570	COG4552	Acetyltransferase involved in intracellular survival and related
I3U44_RS22575	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3U44_RS22600	COG1505	serine-type exopeptidase activity
I3U44_RS22620	COG2326	polyphosphate kinase activity
I3U44_RS22635	COG2223	nitrite transmembrane transporter activity
I3U44_RS22670	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
I3U44_RS22690	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I3U44_RS22715	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I3U44_RS22720	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I3U44_RS22725	COG1028	Short-chain dehydrogenase reductase Sdr
I3U44_RS22735	COG1960	acyl-CoA dehydrogenase activity
I3U44_RS22740	COG1960	acyl-CoA dehydrogenase activity
I3U44_RS22745	COG0318	PFAM AMP-dependent synthetase and ligase
I3U44_RS22755	COG2070	2-Nitropropane dioxygenase
I3U44_RS22765	COG1024	Enoyl-CoA hydratase
I3U44_RS22770	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I3U44_RS22775	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3U44_RS22810	COG4638	Rieske (2fe-2S)
I3U44_RS22850	COG0175	sulfate reduction
I3U44_RS22920	COG2814	Major facilitator Superfamily
I3U44_RS22930	COG0351	phosphomethylpyrimidine kinase
I3U44_RS22940	COG1252	NADH dehydrogenase
I3U44_RS22950	COG1309	transcriptional regulator
I3U44_RS22960	COG1012	belongs to the aldehyde dehydrogenase family
I3U44_RS22995	COG0494	nUDIX hydrolase
I3U44_RS23005	COG2234	aminopeptidase activity
I3U44_RS23010	COG2234	aminopeptidase activity
I3U44_RS23020	COG1131	(ABC) transporter
I3U44_RS23025	COG2022	thiamine diphosphate biosynthetic process
I3U44_RS23060	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I3U44_RS23065	COG0515	serine threonine protein kinase
I3U44_RS23070	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I3U44_RS23100	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I3U44_RS23105	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3U44_RS23110	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3U44_RS23115	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3U44_RS23125	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I3U44_RS23130	COG1126	abc transporter atp-binding protein
I3U44_RS23135	COG0765	amino acid transport
I3U44_RS23150	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
I3U44_RS23180	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
I3U44_RS23215	COG1994	Peptidase M50
I3U44_RS23235	COG0586	Pfam SNARE associated Golgi protein
I3U44_RS23265	COG4221	oxidoreductase activity
I3U44_RS23285	COG0542	response to heat
I3U44_RS23310	COG0789	Transcriptional regulator
I3U44_RS23315	COG0484	heat shock protein binding
I3U44_RS23320	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I3U44_RS23400	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I3U44_RS23400	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I3U44_RS23420	COG2259	Doxx family
I3U44_RS23440	COG2181	nitrate reductase activity
I3U44_RS23440	COG0247	lactate metabolic process
I3U44_RS23450	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I3U44_RS23490	COG3345	alpha-galactosidase
I3U44_RS23495	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I3U44_RS23500	COG1305	Transglutaminase-like
I3U44_RS23515	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I3U44_RS23570	COG1012	belongs to the aldehyde dehydrogenase family
I3U44_RS23635	COG1028	Short-chain dehydrogenase reductase Sdr
I3U44_RS23640	COG1960	acyl-CoA dehydrogenase activity
I3U44_RS23655	COG3268	Saccharopine dehydrogenase
I3U44_RS23660	COG0318	PFAM AMP-dependent synthetase and ligase
I3U44_RS23675	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I3U44_RS23680	COG0318	PFAM AMP-dependent synthetase and ligase
I3U44_RS23715	COG1309	transcriptional regulator
I3U44_RS23740	COG1309	transcriptional regulator
I3U44_RS23745	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
I3U44_RS23760	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I3U44_RS23765	COG1984	allophanate hydrolase subunit 2
I3U44_RS23830	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
I3U44_RS23835	COG1802	Transcriptional regulator
I3U44_RS23865	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I3U44_RS23875	COG0473	3-isopropylmalate dehydrogenase activity
I3U44_RS23890	COG1053	succinate dehydrogenase
I3U44_RS23910	COG0640	Transcriptional regulator
I3U44_RS23955	COG2318	DinB family
I3U44_RS23960	COG1960	acyl-CoA dehydrogenase activity
I3U44_RS23975	COG1660	Displays ATPase and GTPase activities
I3U44_RS23985	COG0183	Belongs to the thiolase family
I3U44_RS24190	COG5280	Phage tail tape measure protein TP901
I3U44_RS24190	COG3953	SLT domain
I3U44_RS24295	COG4974	Belongs to the 'phage' integrase family
I3U44_RS24300	COG1028	Short-chain dehydrogenase reductase Sdr
I3U44_RS24305	COG2030	dehydratase
I3U44_RS24320	COG0659	secondary active sulfate transmembrane transporter activity
I3U44_RS24325	COG1309	transcriptional regulator
I3U44_RS24330	COG1253	flavin adenine dinucleotide binding
I3U44_RS24355	COG0318	PFAM AMP-dependent synthetase and ligase
I3U44_RS24370	COG1472	Belongs to the glycosyl hydrolase 3 family
I3U44_RS24375	COG4941	Belongs to the sigma-70 factor family
I3U44_RS24425	COG4981	capsule polysaccharide biosynthetic process
I3U44_RS24465	COG0438	transferase activity, transferring glycosyl groups
I3U44_RS24510	COG1250	3-hydroxyacyl-CoA dehydrogenase
I3U44_RS24555	COG2197	response regulator
I3U44_RS24560	COG3850	Histidine kinase
I3U44_RS24580	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
I3U44_RS24610	COG2409	Drug exporters of the RND superfamily
I3U44_RS24655	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I3U44_RS24665	COG2197	response regulator
I3U44_RS24695	COG2353	YceI-like domain
I3U44_RS24710	COG2409	Drug exporters of the RND superfamily
I3U44_RS24725	COG4552	Acetyltransferase involved in intracellular survival and related
I3U44_RS24730	COG1832	CoA-binding protein
I3U44_RS24745	COG3590	peptidase
I3U44_RS24750	COG1376	ErfK ybiS ycfS ynhG family protein
I3U44_RS24755	COG1960	acyl-CoA dehydrogenase activity
I3U44_RS24765	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I3U44_RS24775	COG1937	Protein conserved in bacteria
I3U44_RS24805	COG4122	O-methyltransferase activity
I3U44_RS24820	COG2267	carboxylic ester hydrolase activity
I3U44_RS24850	COG1704	LemA family
I3U44_RS24860	COG0318	PFAM AMP-dependent synthetase and ligase
I3U44_RS24915	COG1024	Enoyl-CoA hydratase
I3U44_RS24920	COG1802	Transcriptional regulator
I3U44_RS24930	COG2267	carboxylic ester hydrolase activity
I3U44_RS24935	COG1309	transcriptional regulator
I3U44_RS24965	COG0435	Glutathione S-transferase
I3U44_RS25005	COG1024	Enoyl-CoA hydratase
I3U44_RS25015	COG2211	Major facilitator Superfamily
I3U44_RS25020	COG2365	Tyrosine phosphatase family
I3U44_RS25070	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I3U44_RS25085	COG1028	Short-chain dehydrogenase reductase Sdr
I3U44_RS25090	COG1012	belongs to the aldehyde dehydrogenase family
I3U44_RS25105	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I3U44_RS25110	COG1960	acyl-CoA dehydrogenase activity
I3U44_RS25115	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
I3U44_RS25130	COG2264	protein methyltransferase activity
I3U44_RS25145	COG3800	Transcriptional regulator
I3U44_RS25145	COG1396	sequence-specific DNA binding
I3U44_RS25155	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
I3U44_RS25200	COG0318	PFAM AMP-dependent synthetase and ligase
I3U44_RS25260	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I3U44_RS25270	COG0129	dihydroxy-acid dehydratase activity
I3U44_RS25290	COG2186	Transcriptional regulator
I3U44_RS25320	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I3U44_RS25325	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I3U44_RS25355	COG1028	Short-chain dehydrogenase reductase Sdr
I3U44_RS25395	COG1028	Short-chain dehydrogenase reductase Sdr
I3U44_RS25410	COG0318	PFAM AMP-dependent synthetase and ligase
I3U44_RS25415	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I3U44_RS25420	COG1136	(ABC) transporter
I3U44_RS25430	COG1104	cysteine desulfurase activity
I3U44_RS25445	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I3U44_RS25490	COG1309	transcriptional regulator
I3U44_RS25495	COG1819	glycosyl
I3U44_RS25660	COG3263	regulation of cellular component size
I3U44_RS25740	COG1595	DNA-templated transcription, initiation
I3U44_RS25750	COG0783	Belongs to the Dps family
I3U44_RS25765	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I3U44_RS25790	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I3U44_RS25795	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I3U44_RS25810	COG1937	Protein conserved in bacteria
I3U44_RS25835	COG1403	HNH endonuclease
I3U44_RS25905	COG2140	Oxalate decarboxylase
I3U44_RS25930	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
I3U44_RS25950	COG1376	ErfK ybiS ycfS ynhG family protein
I3U44_RS25970	COG2030	dehydratase
I3U44_RS25975	COG0488	(ABC) transporter
I3U44_RS25980	COG3757	hydrolase, family 25
I3U44_RS26045	COG0583	DNA-binding transcription factor activity
I3U44_RS26055	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3U44_RS26070	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I3U44_RS26075	COG3757	hydrolase, family 25
I3U44_RS26125	COG0629	single-stranded DNA binding
I3U44_RS26140	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I3U44_RS26170	COG1260	myo-inositol-1-phosphate synthase
I3U44_RS26175	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3U44_RS26180	COG1113	amino acid transport
I3U44_RS26195	COG1309	transcriptional regulator
I3U44_RS26200	COG1028	Short-chain dehydrogenase reductase Sdr
I3U44_RS26215	COG0508	dehydrogenase complex catalyzes the overall conversion of
I3U44_RS26220	COG0022	dehydrogenase e1 component
I3U44_RS26235	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
I3U44_RS26240	COG2311	Membrane
I3U44_RS26305	COG0617	tRNA 3'-terminal CCA addition
I3U44_RS26325	COG1595	DNA-templated transcription, initiation
I3U44_RS26345	COG0860	N-Acetylmuramoyl-L-alanine amidase
I3U44_RS26345	COG3409	Peptidoglycan-binding domain 1 protein
I3U44_RS26355	COG2124	cytochrome p450
I3U44_RS26365	COG1309	transcriptional regulator
I3U44_RS26385	COG1192	Involved in chromosome partitioning
I3U44_RS26390	COG0357	Ribosomal RNA small subunit methyltransferase G
I3U44_RS26400	COG0706	membrane insertase activity
I3U44_RS26405	COG0759	Could be involved in insertion of integral membrane proteins into the membrane