locus-tag	class	description
I2T84_RS00020	COG0592	DNA-directed DNA polymerase activity
I2T84_RS00025	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
I2T84_RS00030	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I2T84_RS00035	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
I2T84_RS00040	COG0187	DNA topoisomerase II activity
I2T84_RS00125	COG2814	Major facilitator Superfamily
I2T84_RS00130	COG0583	DNA-binding transcription factor activity
I2T84_RS00145	COG0705	Rhomboid family
I2T84_RS00145	COG0457	Tetratricopeptide repeat
I2T84_RS00175	COG0515	serine threonine protein kinase
I2T84_RS00175	COG2815	serine threonine protein kinase
I2T84_RS00180	COG0515	serine threonine protein kinase
I2T84_RS00185	COG0768	penicillin binding
I2T84_RS00200	COG1716	ATPase activity
I2T84_RS00205	COG1716	ATPase activity
I2T84_RS00250	COG0754	glutathionylspermidine amidase activity
I2T84_RS00270	COG1309	transcriptional regulator
I2T84_RS00290	COG4842	Belongs to the WXG100 family
I2T84_RS00310	COG0590	tRNA wobble adenosine to inosine editing
I2T84_RS00320	COG0583	DNA-binding transcription factor activity
I2T84_RS00330	COG1028	Short-chain dehydrogenase reductase Sdr
I2T84_RS00360	COG1960	acyl-CoA dehydrogenase activity
I2T84_RS00405	COG2072	flavoprotein involved in K transport
I2T84_RS00415	COG0346	lactoylglutathione lyase activity
I2T84_RS00420	COG1414	Transcriptional regulator
I2T84_RS00440	COG1053	succinate dehydrogenase
I2T84_RS00470	COG1785	Belongs to the alkaline phosphatase family
I2T84_RS00490	COG0067	glutamate synthase
I2T84_RS00490	COG0069	glutamate synthase activity
I2T84_RS00490	COG0070	glutamate synthase
I2T84_RS00520	COG1796	DNA polymerase
I2T84_RS00520	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I2T84_RS00530	COG2072	flavoprotein involved in K transport
I2T84_RS00540	COG2124	cytochrome p450
I2T84_RS00585	COG2372	response to copper ion
I2T84_RS00635	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I2T84_RS00655	COG5001	Diguanylate cyclase
I2T84_RS00655	COG3447	MASE1 domain protein
I2T84_RS00655	COG5002	protein histidine kinase activity
I2T84_RS00665	COG1528	Iron-storage protein
I2T84_RS00670	COG1528	Iron-storage protein
I2T84_RS00675	COG1316	TRANSCRIPTIONal
I2T84_RS00700	COG0406	alpha-ribazole phosphatase activity
I2T84_RS00710	COG0028	Belongs to the TPP enzyme family
I2T84_RS00735	COG2072	flavoprotein involved in K transport
I2T84_RS00745	COG2072	flavoprotein involved in K transport
I2T84_RS00765	COG1285	pathogenesis
I2T84_RS00815	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I2T84_RS00815	COG2146	nitrite reductase [NAD(P)H] activity
I2T84_RS00825	COG4133	protoheme IX ABC transporter activity
I2T84_RS00830	COG2070	2-Nitropropane dioxygenase
I2T84_RS00835	COG1942	4-Oxalocrotonate Tautomerase
I2T84_RS00840	COG0583	DNA-binding transcription factor activity
I2T84_RS00855	COG1028	Short-chain dehydrogenase reductase Sdr
I2T84_RS00860	COG0204	Acyl-transferase
I2T84_RS00870	COG0561	phosphatase activity
I2T84_RS00890	COG1216	Glycosyl transferase, family 2
I2T84_RS00895	COG0671	phosphoesterase, PA-phosphatase related
I2T84_RS00900	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I2T84_RS00905	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I2T84_RS00925	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
I2T84_RS00930	COG0318	PFAM AMP-dependent synthetase and ligase
I2T84_RS00935	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I2T84_RS00935	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
I2T84_RS00935	COG3321	synthase
I2T84_RS00940	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I2T84_RS00990	COG1028	Short-chain dehydrogenase reductase Sdr
I2T84_RS00995	COG0277	FAD linked oxidase domain protein
I2T84_RS01005	COG2376	Dihydroxyacetone kinase
I2T84_RS01010	COG2267	carboxylic ester hydrolase activity
I2T84_RS01015	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I2T84_RS01020	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I2T84_RS01035	COG0671	phosphoesterase, PA-phosphatase related
I2T84_RS01045	COG1216	Glycosyl transferase, family 2
I2T84_RS01125	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I2T84_RS01130	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I2T84_RS01400	COG3547	Transposase (IS116 IS110 IS902 family)
I2T84_RS01410	COG2304	oxidoreductase activity
I2T84_RS01705	COG4974	Belongs to the 'phage' integrase family
I2T84_RS01795	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I2T84_RS01870	COG1960	acyl-CoA dehydrogenase activity
I2T84_RS01885	COG1028	Short-chain dehydrogenase reductase Sdr
I2T84_RS01905	COG1174	glycine betaine transport
I2T84_RS01920	COG0287	Prephenate dehydrogenase
I2T84_RS01930	COG0590	tRNA wobble adenosine to inosine editing
I2T84_RS01955	COG0343	queuine tRNA-ribosyltransferase activity
I2T84_RS01965	COG0765	amino acid transport
I2T84_RS01970	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I2T84_RS01975	COG1793	dna ligase
I2T84_RS02005	COG2271	Major facilitator Superfamily
I2T84_RS02010	COG0604	alcohol dehydrogenase
I2T84_RS02035	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I2T84_RS02060	COG1028	Short-chain dehydrogenase reductase Sdr
I2T84_RS02090	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I2T84_RS02115	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I2T84_RS02125	COG0148	phosphopyruvate hydratase activity
I2T84_RS02155	COG0860	N-Acetylmuramoyl-L-alanine amidase
I2T84_RS02170	COG1492	cobalamin metabolic process
I2T84_RS02195	COG1960	acyl-CoA dehydrogenase activity
I2T84_RS02210	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I2T84_RS02240	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I2T84_RS02285	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I2T84_RS02295	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I2T84_RS02325	COG2070	2-Nitropropane dioxygenase
I2T84_RS02360	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I2T84_RS02365	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I2T84_RS02370	COG2971	BadF BadG BcrA BcrD
I2T84_RS02375	COG2814	Major facilitator Superfamily
I2T84_RS02395	COG3572	ergothioneine biosynthetic process
I2T84_RS02400	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I2T84_RS02405	COG0121	glutamine amidotransferase
I2T84_RS02410	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
I2T84_RS02415	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I2T84_RS02445	COG2030	dehydratase
I2T84_RS02450	COG1028	Short-chain dehydrogenase reductase Sdr
I2T84_RS02455	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I2T84_RS02465	COG1695	Transcriptional regulator
I2T84_RS02475	COG0569	domain protein
I2T84_RS02475	COG0475	glutathione-regulated potassium exporter activity
I2T84_RS02495	COG0714	Associated with various cellular activities
I2T84_RS02535	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I2T84_RS02540	COG1074	ATP-dependent DNA helicase activity
I2T84_RS02545	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I2T84_RS02555	COG2755	lipolytic protein G-D-S-L family
I2T84_RS02665	COG4974	Belongs to the 'phage' integrase family
I2T84_RS02675	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I2T84_RS02680	COG1408	metallophosphoesterase
I2T84_RS02685	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I2T84_RS02715	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I2T84_RS02755	COG0596	Alpha beta hydrolase
I2T84_RS02755	COG2945	thiolester hydrolase activity
I2T84_RS02770	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I2T84_RS02775	COG0747	negative chemotaxis
I2T84_RS02785	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I2T84_RS02870	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I2T84_RS02940	COG0582	viral genome integration into host DNA
I2T84_RS02985	COG2217	Heavy metal translocating P-type atpase
I2T84_RS02995	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I2T84_RS03055	COG2132	Multicopper oxidase
I2T84_RS03090	COG0596	Alpha beta hydrolase
I2T84_RS03145	COG1695	Transcriptional regulator
I2T84_RS03150	COG0657	acetylesterase activity
I2T84_RS03155	COG1902	pentaerythritol trinitrate reductase activity
I2T84_RS03160	COG1205	dead DEAH box helicase
I2T84_RS03160	COG1111	helicase
I2T84_RS03165	COG1278	Cold shock
I2T84_RS03175	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I2T84_RS03175	COG1754	DNA topoisomerase type I activity
I2T84_RS03300	COG1215	transferase activity, transferring glycosyl groups
I2T84_RS03330	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I2T84_RS03365	COG2027	D-alanyl-D-alanine carboxypeptidase
I2T84_RS03395	COG1063	alcohol dehydrogenase
I2T84_RS03405	COG2267	carboxylic ester hydrolase activity
I2T84_RS03415	COG1309	transcriptional regulator
I2T84_RS03430	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I2T84_RS03475	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
I2T84_RS03485	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I2T84_RS03505	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
I2T84_RS03510	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I2T84_RS03550	COG4977	sequence-specific DNA binding
I2T84_RS03555	COG1194	a g-specific adenine glycosylase
I2T84_RS03565	COG1316	TRANSCRIPTIONal
I2T84_RS03575	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
I2T84_RS03585	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I2T84_RS03605	COG1329	Transcriptional regulator
I2T84_RS03610	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
I2T84_RS03620	COG0215	cysteine-tRNA ligase activity
I2T84_RS03630	COG0584	glycerophosphoryl diester phosphodiesterase
I2T84_RS03640	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I2T84_RS03645	COG1120	ATPase activity
I2T84_RS03650	COG0803	Belongs to the bacterial solute-binding protein 9 family
I2T84_RS03660	COG1309	transcriptional regulator
I2T84_RS03665	COG1960	acyl-CoA dehydrogenase activity
I2T84_RS03680	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I2T84_RS03690	COG0346	lactoylglutathione lyase activity
I2T84_RS03730	COG1960	acyl-CoA dehydrogenase activity
I2T84_RS03735	COG1960	acyl-CoA dehydrogenase activity
I2T84_RS03740	COG1960	acyl-CoA dehydrogenase activity
I2T84_RS03745	COG0318	PFAM AMP-dependent synthetase and ligase
I2T84_RS03750	COG1960	acyl-CoA dehydrogenase activity
I2T84_RS03765	COG0183	Belongs to the thiolase family
I2T84_RS03795	COG1024	Enoyl-CoA hydratase
I2T84_RS03800	COG1028	Short-chain dehydrogenase reductase Sdr
I2T84_RS03805	COG1028	Short-chain dehydrogenase reductase Sdr
I2T84_RS03825	COG0183	Belongs to the thiolase family
I2T84_RS03835	COG1960	acyl-CoA dehydrogenase activity
I2T84_RS03840	COG1960	acyl-CoA dehydrogenase activity
I2T84_RS03845	COG2030	dehydratase
I2T84_RS03870	COG2030	dehydratase
I2T84_RS03875	COG1053	succinate dehydrogenase
I2T84_RS03885	COG3971	2-oxopent-4-enoate hydratase activity
I2T84_RS03925	COG0651	ATP synthesis coupled electron transport
I2T84_RS03935	COG2111	Na H antiporter
I2T84_RS03935	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I2T84_RS03940	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I2T84_RS03960	COG0647	UMP catabolic process
I2T84_RS03995	COG4221	oxidoreductase activity
I2T84_RS04015	COG0459	protein refolding
I2T84_RS04030	COG0714	Associated with various cellular activities
I2T84_RS04080	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I2T84_RS04095	COG4842	Belongs to the WXG100 family
I2T84_RS04140	COG0745	RESPONSE REGULATOR receiver
I2T84_RS04145	COG5000	phosphorelay sensor kinase activity
I2T84_RS04145	COG5002	protein histidine kinase activity
I2T84_RS04150	COG0537	adenosine 5'-monophosphoramidase activity
I2T84_RS04155	COG0697	spore germination
I2T84_RS04165	COG0596	Alpha beta hydrolase
I2T84_RS04195	COG0436	Aminotransferase
I2T84_RS04205	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I2T84_RS04225	COG1028	Short-chain dehydrogenase reductase Sdr
I2T84_RS04230	COG0477	Major facilitator Superfamily
I2T84_RS04235	COG0386	Belongs to the glutathione peroxidase family
I2T84_RS04245	COG3573	Dehydrogenase
I2T84_RS04255	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I2T84_RS04270	COG2837	iron assimilation
I2T84_RS04275	COG1362	aminopeptidase activity
I2T84_RS04350	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I2T84_RS04360	COG0601	transmembrane transport
I2T84_RS04365	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I2T84_RS04400	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I2T84_RS04410	COG0354	folic acid binding
I2T84_RS04455	COG2897	thiosulfate sulfurtransferase activity
I2T84_RS04475	COG0745	RESPONSE REGULATOR receiver
I2T84_RS04495	COG0581	inorganic phosphate transmembrane transporter activity
I2T84_RS04500	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I2T84_RS04505	COG0604	alcohol dehydrogenase
I2T84_RS04560	COG1250	3-hydroxyacyl-CoA dehydrogenase
I2T84_RS04585	COG0697	spore germination
I2T84_RS04605	COG0442	prolyl-tRNA aminoacylation
I2T84_RS04610	COG2814	Major facilitator Superfamily
I2T84_RS04640	COG5651	PPE family
I2T84_RS04645	COG0436	Aminotransferase
I2T84_RS04665	COG0531	amino acid
I2T84_RS04670	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
I2T84_RS04675	COG1012	belongs to the aldehyde dehydrogenase family
I2T84_RS04685	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I2T84_RS04695	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I2T84_RS04700	COG1960	acyl-CoA dehydrogenase activity
I2T84_RS04705	COG1012	belongs to the aldehyde dehydrogenase family
I2T84_RS04710	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I2T84_RS04725	COG1028	Short-chain dehydrogenase reductase Sdr
I2T84_RS04740	COG1028	Short-chain dehydrogenase reductase Sdr
I2T84_RS04755	COG1024	Enoyl-CoA hydratase
I2T84_RS04800	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I2T84_RS04805	COG0657	acetylesterase activity
I2T84_RS04825	COG0183	Belongs to the thiolase family
I2T84_RS04840	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I2T84_RS04860	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I2T84_RS04875	COG1061	Type III restriction enzyme res subunit
I2T84_RS04915	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I2T84_RS04940	COG1278	Cold shock
I2T84_RS04980	COG2814	Major facilitator Superfamily
I2T84_RS05055	COG1764	response to oxidative stress
I2T84_RS05060	COG1846	Transcriptional regulator
I2T84_RS05065	COG1216	Glycosyl transferase, family 2
I2T84_RS05070	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I2T84_RS05070	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I2T84_RS05100	COG0259	pyridoxamine-phosphate oxidase activity
I2T84_RS05110	COG0318	PFAM AMP-dependent synthetase and ligase
I2T84_RS05115	COG5651	PPE family
I2T84_RS05145	COG4977	sequence-specific DNA binding
I2T84_RS05170	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I2T84_RS05180	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I2T84_RS05190	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I2T84_RS05195	COG1028	Short-chain dehydrogenase reductase Sdr
I2T84_RS05200	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I2T84_RS05205	COG0545	Peptidyl-prolyl cis-trans isomerase
I2T84_RS05225	COG2072	flavoprotein involved in K transport
I2T84_RS05245	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I2T84_RS05250	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
I2T84_RS05295	COG1012	belongs to the aldehyde dehydrogenase family
I2T84_RS05310	COG3022	response to hydroperoxide
I2T84_RS05320	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I2T84_RS05355	COG1309	transcriptional regulator
I2T84_RS05385	COG1393	Belongs to the ArsC family
I2T84_RS05430	COG0183	Belongs to the thiolase family
I2T84_RS05475	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I2T84_RS05515	COG0438	transferase activity, transferring glycosyl groups
I2T84_RS05520	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I2T84_RS05525	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I2T84_RS05585	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
I2T84_RS05590	COG1846	Transcriptional regulator
I2T84_RS05610	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
I2T84_RS05640	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I2T84_RS05650	COG2326	polyphosphate kinase activity
I2T84_RS05670	COG0523	cobalamin synthesis protein
I2T84_RS05675	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I2T84_RS05680	COG0235	Class ii aldolase
I2T84_RS05685	COG1396	sequence-specific DNA binding
I2T84_RS05690	COG0166	Belongs to the GPI family
I2T84_RS05735	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I2T84_RS05795	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I2T84_RS05825	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I2T84_RS05830	COG0521	Mo-molybdopterin cofactor biosynthetic process
I2T84_RS05830	COG0315	cyclic pyranopterin monophosphate synthase activity
I2T84_RS05865	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I2T84_RS05870	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I2T84_RS05965	COG2235	arginine
I2T84_RS05980	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I2T84_RS05995	COG1252	NADH dehydrogenase
I2T84_RS06005	COG0084	hydrolase, TatD family'
I2T84_RS06010	COG3583	domain protein
I2T84_RS06025	COG2815	serine threonine protein kinase
I2T84_RS06025	COG0515	serine threonine protein kinase
I2T84_RS06045	COG1846	Transcriptional regulator
I2T84_RS06045	COG0456	acetyltransferase
I2T84_RS06050	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I2T84_RS06055	COG0318	PFAM AMP-dependent synthetase and ligase
I2T84_RS06070	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I2T84_RS06105	COG1309	transcriptional regulator
I2T84_RS06150	COG3956	TIGRFAM MazG family protein
I2T84_RS06165	COG2837	iron assimilation
I2T84_RS06170	COG2822	iron ion transport
I2T84_RS06205	COG0596	Alpha beta hydrolase
I2T84_RS06230	COG0318	PFAM AMP-dependent synthetase and ligase
I2T84_RS06240	COG0427	acetyl-CoA hydrolase
I2T84_RS06295	COG1846	Transcriptional regulator
I2T84_RS06310	COG1024	Enoyl-CoA hydratase
I2T84_RS06335	COG0183	Belongs to the thiolase family
I2T84_RS06340	COG2755	lipolytic protein G-D-S-L family
I2T84_RS06345	COG0657	acetylesterase activity
I2T84_RS06355	COG1714	RDD family
I2T84_RS06370	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I2T84_RS06390	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I2T84_RS06400	COG1331	Highly conserved protein containing a thioredoxin domain
I2T84_RS06405	COG3631	Ketosteroid isomerase-related protein
I2T84_RS06420	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I2T84_RS06425	COG1028	Short-chain dehydrogenase reductase Sdr
I2T84_RS06430	COG2124	cytochrome p450
I2T84_RS06450	COG1028	Short-chain dehydrogenase reductase Sdr
I2T84_RS06490	COG2272	Belongs to the type-B carboxylesterase lipase family
I2T84_RS06500	COG1174	glycine betaine transport
I2T84_RS06510	COG1174	glycine betaine transport
I2T84_RS06555	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I2T84_RS06565	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
I2T84_RS06570	COG0726	polysaccharide deacetylase
I2T84_RS06635	COG1722	exodeoxyribonuclease VII activity
I2T84_RS06640	COG1570	exodeoxyribonuclease VII activity
I2T84_RS06650	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I2T84_RS06665	COG1966	Carbon starvation protein
I2T84_RS06690	COG3189	MarR family transcriptional regulator
I2T84_RS06695	COG0012	GTP binding
I2T84_RS06710	COG2132	Multicopper oxidase
I2T84_RS06720	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I2T84_RS06730	COG0488	(ABC) transporter
I2T84_RS06785	COG2409	Drug exporters of the RND superfamily
I2T84_RS06820	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I2T84_RS06840	COG1716	ATPase activity
I2T84_RS06870	COG1051	belongs to the nudix hydrolase family
I2T84_RS06895	COG1217	gtp-binding protein TYPA
I2T84_RS06905	COG2015	COG2015, Alkyl sulfatase and related hydrolases
I2T84_RS06970	COG1902	pentaerythritol trinitrate reductase activity
I2T84_RS06970	COG0446	pyridine nucleotide-disulphide oxidoreductase
I2T84_RS06980	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
I2T84_RS06990	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I2T84_RS06995	COG1012	belongs to the aldehyde dehydrogenase family
I2T84_RS07000	COG0506	proline dehydrogenase activity
I2T84_RS07005	COG0318	PFAM AMP-dependent synthetase and ligase
I2T84_RS07030	COG2207	Transcriptional regulator
I2T84_RS07045	COG1611	Belongs to the LOG family
I2T84_RS07050	COG1611	Belongs to the LOG family
I2T84_RS07055	COG0318	PFAM AMP-dependent synthetase and ligase
I2T84_RS07065	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I2T84_RS07070	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I2T84_RS07075	COG0463	Glycosyl transferase, family 2
I2T84_RS07090	COG0519	Catalyzes the synthesis of GMP from XMP
I2T84_RS07100	COG0297	glycogen (starch) synthase activity
I2T84_RS07115	COG3559	Exporter of polyketide antibiotics
I2T84_RS07120	COG1131	(ABC) transporter
I2T84_RS07125	COG1309	transcriptional regulator
I2T84_RS07135	COG1595	DNA-templated transcription, initiation
I2T84_RS07140	COG5662	AntiSigma factor
I2T84_RS07145	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I2T84_RS07215	COG0598	Magnesium transport protein CorA
I2T84_RS07220	COG2095	MarC family integral membrane protein
I2T84_RS07235	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I2T84_RS07240	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I2T84_RS07260	COG3835	regulator
I2T84_RS07265	COG1073	alpha beta
I2T84_RS07270	COG0508	dehydrogenase complex catalyzes the overall conversion of
I2T84_RS07270	COG0567	Dehydrogenase, E1 component
I2T84_RS07280	COG2814	Major facilitator Superfamily
I2T84_RS07340	COG0277	FAD linked oxidase domain protein
I2T84_RS07345	COG1028	Short-chain dehydrogenase reductase Sdr
I2T84_RS07360	COG0668	transmembrane transport
I2T84_RS07395	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I2T84_RS07455	COG2814	Major facilitator Superfamily
I2T84_RS07485	COG0019	diaminopimelate decarboxylase activity
I2T84_RS07490	COG0460	homoserine dehydrogenase
I2T84_RS07495	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I2T84_RS07535	COG2890	protein-(glutamine-N5) methyltransferase activity
I2T84_RS07545	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I2T84_RS07555	COG0356	it plays a direct role in the translocation of protons across the membrane
I2T84_RS07560	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I2T84_RS07585	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I2T84_RS07645	COG0346	lactoylglutathione lyase activity
I2T84_RS07650	COG0183	Belongs to the thiolase family
I2T84_RS07655	COG2409	Drug exporters of the RND superfamily
I2T84_RS07670	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I2T84_RS07675	COG0366	Alpha amylase catalytic
I2T84_RS07680	COG0058	SHG alpha-glucan phosphorylase activity
I2T84_RS07695	COG1335	isochorismatase
I2T84_RS07705	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I2T84_RS07720	COG3191	aminopeptidase activity
I2T84_RS07785	COG0318	PFAM AMP-dependent synthetase and ligase
I2T84_RS07800	COG0419	ATPase involved in DNA repair
I2T84_RS07805	COG1024	Enoyl-CoA hydratase
I2T84_RS07815	COG0243	molybdopterin cofactor binding
I2T84_RS07830	COG2188	Transcriptional regulator
I2T84_RS07840	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I2T84_RS07885	COG0596	Alpha beta hydrolase
I2T84_RS07890	COG3757	hydrolase, family 25
I2T84_RS07905	COG1051	belongs to the nudix hydrolase family
I2T84_RS07925	COG1309	transcriptional regulator
I2T84_RS07940	COG4585	Histidine kinase
I2T84_RS07945	COG2197	response regulator
I2T84_RS07955	COG2239	Acts as a magnesium transporter
I2T84_RS07965	COG0300	oxidoreductase activity
I2T84_RS07975	COG0656	L-ascorbic acid biosynthetic process
I2T84_RS07990	COG1376	ErfK ybiS ycfS ynhG family protein
I2T84_RS08005	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I2T84_RS08010	COG0433	COG0433 Predicted ATPase
I2T84_RS08025	COG0300	oxidoreductase activity
I2T84_RS08040	COG1301	dicarboxylic acid transport
I2T84_RS08050	COG0531	amino acid
I2T84_RS08070	COG4424	Sulfotransferase
I2T84_RS08075	COG3119	arylsulfatase activity
I2T84_RS08115	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I2T84_RS08115	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I2T84_RS08120	COG0662	Cupin 2, conserved barrel domain protein
I2T84_RS08150	COG2902	Dehydrogenase
I2T84_RS08155	COG0824	Thioesterase
I2T84_RS08170	COG0366	Alpha amylase catalytic
I2T84_RS08205	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I2T84_RS08225	COG1309	transcriptional regulator
I2T84_RS08240	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
I2T84_RS08260	COG0740	serine-type endopeptidase activity
I2T84_RS08265	COG0740	serine-type endopeptidase activity
I2T84_RS08315	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I2T84_RS08325	COG0674	pyruvate-flavodoxin oxidoreductase activity
I2T84_RS08325	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I2T84_RS08330	COG1013	pyruvate-flavodoxin oxidoreductase activity
I2T84_RS08340	COG1388	LysM domain
I2T84_RS08370	COG0525	valine-tRNA ligase activity
I2T84_RS08375	COG0285	dihydrofolate synthase activity
I2T84_RS08390	COG1530	ribonuclease E activity
I2T84_RS08390	COG1530	ribonuclease E activity
I2T84_RS08410	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I2T84_RS08430	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I2T84_RS08435	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I2T84_RS08440	COG0542	response to heat
I2T84_RS08450	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I2T84_RS08460	COG0406	alpha-ribazole phosphatase activity
I2T84_RS08465	COG2755	lipolytic protein G-D-S-L family
I2T84_RS08485	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I2T84_RS08520	COG2308	Evidence 4 Homologs of previously reported genes of
I2T84_RS08530	COG1305	Transglutaminase-like
I2T84_RS08560	COG3387	PFAM Glycoside hydrolase 15-related
I2T84_RS08575	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I2T84_RS08610	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
I2T84_RS08615	COG4208	sulfate ABC transporter
I2T84_RS08670	COG0484	heat shock protein binding
I2T84_RS08720	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I2T84_RS08765	COG0076	glutamate decarboxylase activity
I2T84_RS08800	COG0318	PFAM AMP-dependent synthetase and ligase
I2T84_RS08805	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I2T84_RS08850	COG0423	glycine-tRNA ligase activity
I2T84_RS08855	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I2T84_RS08860	COG2515	1-aminocyclopropane-1-carboxylate deaminase
I2T84_RS08880	COG0358	DNA primase activity
I2T84_RS09320	COG0745	RESPONSE REGULATOR receiver
I2T84_RS09325	COG5002	protein histidine kinase activity
I2T84_RS09345	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I2T84_RS09415	COG0488	(ABC) transporter
I2T84_RS09440	COG1960	acyl-CoA dehydrogenase activity
I2T84_RS09445	COG1335	isochorismatase
I2T84_RS09455	COG0058	SHG alpha-glucan phosphorylase activity
I2T84_RS09495	COG1960	acyl-CoA dehydrogenase activity
I2T84_RS09500	COG0183	Belongs to the thiolase family
I2T84_RS09515	COG1228	amidohydrolase
I2T84_RS09545	COG1028	Short-chain dehydrogenase reductase Sdr
I2T84_RS09545	COG3321	synthase
I2T84_RS09545	COG0604	alcohol dehydrogenase
I2T84_RS09565	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I2T84_RS09595	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I2T84_RS09670	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
I2T84_RS09675	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
I2T84_RS09735	COG0714	Associated with various cellular activities
I2T84_RS09780	COG0557	exoribonuclease II activity
I2T84_RS09790	COG0318	PFAM AMP-dependent synthetase and ligase
I2T84_RS09815	COG0174	glutamine synthetase
I2T84_RS09820	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I2T84_RS09850	COG2205	protein histidine kinase activity
I2T84_RS09900	COG0174	glutamine synthetase
I2T84_RS09910	COG0477	Major facilitator Superfamily
I2T84_RS09920	COG3486	L-lysine 6-monooxygenase (NADPH) activity
I2T84_RS09940	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I2T84_RS09945	COG0321	lipoyl(octanoyl) transferase activity
I2T84_RS09960	COG1872	DUF167
I2T84_RS09975	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I2T84_RS09980	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I2T84_RS09990	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
I2T84_RS09995	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
I2T84_RS10025	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I2T84_RS10070	COG2010	Cytochrome c
I2T84_RS10075	COG1845	cytochrome c oxidase, subunit III
I2T84_RS10115	COG2226	methyltransferase
I2T84_RS10140	COG0003	Pfam Anion-transporting ATPase
I2T84_RS10150	COG0204	Acyl-transferase
I2T84_RS10155	COG5650	phosphatidylinositol metabolic process
I2T84_RS10165	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
I2T84_RS10190	COG0142	geranyltranstransferase activity
I2T84_RS10230	COG0768	penicillin binding
I2T84_RS10250	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I2T84_RS10260	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I2T84_RS10275	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I2T84_RS10300	COG0640	Transcriptional regulator
I2T84_RS10350	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I2T84_RS10360	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I2T84_RS10370	COG1028	Short-chain dehydrogenase reductase Sdr
I2T84_RS10400	COG2814	Major facilitator Superfamily
I2T84_RS10475	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I2T84_RS10480	COG2030	dehydratase
I2T84_RS10500	COG1024	Enoyl-CoA hydratase
I2T84_RS10515	COG1309	transcriptional regulator
I2T84_RS10535	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I2T84_RS10580	COG2072	flavoprotein involved in K transport
I2T84_RS10590	COG2072	flavoprotein involved in K transport
I2T84_RS10605	COG0318	PFAM AMP-dependent synthetase and ligase
I2T84_RS10610	COG1960	acyl-CoA dehydrogenase activity
I2T84_RS10630	COG1960	acyl-CoA dehydrogenase activity
I2T84_RS10670	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I2T84_RS10700	COG1968	undecaprenyl-diphosphatase activity
I2T84_RS10735	COG1218	3'(2'),5'-bisphosphate nucleotidase
I2T84_RS10745	COG1028	Short-chain dehydrogenase reductase Sdr
I2T84_RS10770	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I2T84_RS10780	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
I2T84_RS10780	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I2T84_RS10795	COG2860	membrane
I2T84_RS10805	COG1410	methionine synthase
I2T84_RS10805	COG0646	methionine synthase
I2T84_RS10810	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I2T84_RS10820	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I2T84_RS10855	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
I2T84_RS10860	COG1034	ATP synthesis coupled electron transport
I2T84_RS10865	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
I2T84_RS10870	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I2T84_RS10910	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I2T84_RS10910	COG1017	nitric oxide dioxygenase activity
I2T84_RS10960	COG0513	Belongs to the DEAD box helicase family
I2T84_RS10995	COG0028	Belongs to the TPP enzyme family
I2T84_RS11010	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I2T84_RS11015	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
I2T84_RS11020	COG4122	O-methyltransferase activity
I2T84_RS11050	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I2T84_RS11055	COG4521	taurine ABC transporter
I2T84_RS11060	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
I2T84_RS11100	COG2378	regulation of single-species biofilm formation
I2T84_RS11105	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I2T84_RS11140	COG0300	oxidoreductase activity
I2T84_RS11195	COG1574	metal-dependent hydrolase with the TIM-barrel fold
I2T84_RS11205	COG0463	Glycosyl transferase, family 2
I2T84_RS11210	COG1028	Short-chain dehydrogenase reductase Sdr
I2T84_RS11235	COG3321	synthase
I2T84_RS11235	COG1028	Short-chain dehydrogenase reductase Sdr
I2T84_RS11235	COG0604	alcohol dehydrogenase
I2T84_RS11255	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I2T84_RS11265	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I2T84_RS11270	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I2T84_RS11290	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
I2T84_RS11300	COG1404	Belongs to the peptidase S8 family
I2T84_RS11315	COG4842	Belongs to the WXG100 family
I2T84_RS11345	COG0464	growth
I2T84_RS11400	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I2T84_RS11405	COG1169	isochorismate synthase
I2T84_RS11410	COG0789	Transcriptional regulator
I2T84_RS11415	COG1021	2,3-dihydroxybenzoate-AMP ligase
I2T84_RS11445	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
I2T84_RS11450	COG1132	(ABC) transporter
I2T84_RS11455	COG1132	(ABC) transporter
I2T84_RS11455	COG2375	cellular response to nickel ion
I2T84_RS11460	COG0477	Major facilitator Superfamily
I2T84_RS11465	COG5285	phytanoyl-CoA dioxygenase
I2T84_RS11475	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I2T84_RS11480	COG0456	acetyltransferase
I2T84_RS11495	COG2837	iron assimilation
I2T84_RS11505	COG2186	Transcriptional regulator
I2T84_RS11510	COG2807	transmembrane transport
I2T84_RS11520	COG2409	Drug exporters of the RND superfamily
I2T84_RS11525	COG3629	intracellular signal transduction
I2T84_RS11530	COG1012	belongs to the aldehyde dehydrogenase family
I2T84_RS11570	COG0475	glutathione-regulated potassium exporter activity
I2T84_RS11635	COG0237	dephospho-CoA kinase activity
I2T84_RS11635	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I2T84_RS11810	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I2T84_RS11815	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I2T84_RS11815	COG0072	phenylalanine-tRNA ligase activity
I2T84_RS11825	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I2T84_RS11830	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I2T84_RS11835	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I2T84_RS11840	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I2T84_RS11845	COG1438	arginine binding
I2T84_RS11850	COG0137	argininosuccinate synthase activity
I2T84_RS11890	COG2835	tetraacyldisaccharide 4'-kinase activity
I2T84_RS11895	COG1309	transcriptional regulator
I2T84_RS11900	COG2094	Belongs to the DNA glycosylase MPG family
I2T84_RS11925	COG0647	UMP catabolic process
I2T84_RS11940	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I2T84_RS11960	COG0504	CTP synthase activity
I2T84_RS11965	COG0494	nUDIX hydrolase
I2T84_RS11980	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I2T84_RS11985	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I2T84_RS12000	COG1160	GTP binding
I2T84_RS12050	COG3976	FMN-binding domain protein
I2T84_RS12050	COG1053	succinate dehydrogenase
I2T84_RS12080	COG1960	acyl-CoA dehydrogenase activity
I2T84_RS12135	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I2T84_RS12135	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I2T84_RS12150	COG1253	flavin adenine dinucleotide binding
I2T84_RS12155	COG1253	flavin adenine dinucleotide binding
I2T84_RS12165	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I2T84_RS12220	COG0832	Belongs to the urease beta subunit family
I2T84_RS12230	COG0830	nickel cation binding
I2T84_RS12245	COG1252	NADH dehydrogenase
I2T84_RS12255	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I2T84_RS12290	COG0243	molybdopterin cofactor binding
I2T84_RS12295	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I2T84_RS12300	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I2T84_RS12315	COG1058	Belongs to the CinA family
I2T84_RS12315	COG1546	Belongs to the CinA family
I2T84_RS12325	COG4977	sequence-specific DNA binding
I2T84_RS12330	COG1741	Belongs to the pirin family
I2T84_RS12350	COG1968	undecaprenyl-diphosphatase activity
I2T84_RS12355	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
I2T84_RS12380	COG0277	FAD linked oxidase domain protein
I2T84_RS12390	COG1309	transcriptional regulator
I2T84_RS12405	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I2T84_RS12410	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I2T84_RS12440	COG4290	ribonuclease
I2T84_RS12470	COG0791	NLP P60 protein
I2T84_RS12470	COG3883	PFAM NLP P60 protein
I2T84_RS12505	COG0477	Major facilitator Superfamily
I2T84_RS12525	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I2T84_RS12530	COG0067	glutamate synthase
I2T84_RS12530	COG0069	glutamate synthase activity
I2T84_RS12530	COG0070	glutamate synthase
I2T84_RS12555	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I2T84_RS12570	COG1960	acyl-CoA dehydrogenase activity
I2T84_RS12585	COG0443	Heat shock 70 kDa protein
I2T84_RS12590	COG0596	Alpha beta hydrolase
I2T84_RS12610	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I2T84_RS12620	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
I2T84_RS12645	COG2890	protein-(glutamine-N5) methyltransferase activity
I2T84_RS12710	COG1982	Orn Lys Arg decarboxylase major
I2T84_RS12775	COG2957	Belongs to the agmatine deiminase family
I2T84_RS12850	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
I2T84_RS12875	COG0288	reversible hydration of carbon dioxide
I2T84_RS12950	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
I2T84_RS13000	COG0640	Transcriptional regulator
I2T84_RS13010	COG0798	PFAM Bile acid sodium symporter
I2T84_RS13015	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I2T84_RS13025	COG0179	Fumarylacetoacetate (FAA) hydrolase
I2T84_RS13095	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
I2T84_RS13100	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
I2T84_RS13125	COG1917	Cupin 2, conserved barrel domain protein
I2T84_RS13130	COG3707	response regulator
I2T84_RS13190	COG0640	Transcriptional regulator
I2T84_RS13210	COG1309	transcriptional regulator
I2T84_RS13215	COG2072	flavoprotein involved in K transport
I2T84_RS13225	COG0318	PFAM AMP-dependent synthetase and ligase
I2T84_RS13230	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I2T84_RS13235	COG0561	phosphatase activity
I2T84_RS13240	COG0673	inositol 2-dehydrogenase activity
I2T84_RS13245	COG0738	Major facilitator superfamily
I2T84_RS13330	COG1271	oxidase subunit
I2T84_RS13335	COG1294	oxidase, subunit
I2T84_RS13340	COG4988	ABC transporter
I2T84_RS13345	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I2T84_RS13370	COG1946	Acyl-CoA thioesterase
I2T84_RS13380	COG2076	Multidrug Resistance protein
I2T84_RS13415	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I2T84_RS13420	COG1846	Transcriptional regulator
I2T84_RS13455	COG0483	inositol monophosphate 1-phosphatase activity
I2T84_RS13465	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I2T84_RS13470	COG0131	Imidazoleglycerol-phosphate dehydratase
I2T84_RS13475	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I2T84_RS13500	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I2T84_RS13515	COG1309	transcriptional regulator
I2T84_RS13530	COG0583	DNA-binding transcription factor activity
I2T84_RS13535	COG0579	oxidoreductase
I2T84_RS13575	COG2755	lipolytic protein G-D-S-L family
I2T84_RS13575	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I2T84_RS13620	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I2T84_RS13640	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I2T84_RS13645	COG2814	Major facilitator Superfamily
I2T84_RS13650	COG0583	DNA-binding transcription factor activity
I2T84_RS13700	COG2239	Acts as a magnesium transporter
I2T84_RS13730	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I2T84_RS13740	COG2304	oxidoreductase activity
I2T84_RS13750	COG0714	Associated with various cellular activities
I2T84_RS13760	COG3883	PFAM NLP P60 protein
I2T84_RS13760	COG0791	NLP P60 protein
I2T84_RS13770	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I2T84_RS13775	COG1309	transcriptional regulator
I2T84_RS13800	COG0488	(ABC) transporter
I2T84_RS13815	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I2T84_RS13830	COG0456	acetyltransferase
I2T84_RS13840	COG2151	metal-sulfur cluster biosynthetic enzyme
I2T84_RS13855	COG0396	ATPase activity
I2T84_RS13880	COG1131	(ABC) transporter
I2T84_RS13900	COG1309	transcriptional regulator
I2T84_RS13925	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I2T84_RS13990	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I2T84_RS14050	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I2T84_RS14110	COG0531	amino acid
I2T84_RS14165	COG2011	ABC-type metal ion transport system permease component
I2T84_RS14170	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I2T84_RS14175	COG1464	Belongs to the NlpA lipoprotein family
I2T84_RS14190	COG0477	Major facilitator Superfamily
I2T84_RS14225	COG0657	acetylesterase activity
I2T84_RS14230	COG1953	Uracil, thiamine, allantoin
I2T84_RS14240	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I2T84_RS14245	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I2T84_RS14255	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I2T84_RS14265	COG1758	RNA polymerase activity
I2T84_RS14285	COG0284	orotidine-5'-phosphate decarboxylase activity
I2T84_RS14290	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I2T84_RS14295	COG0505	Belongs to the CarA family
I2T84_RS14315	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
I2T84_RS14335	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I2T84_RS14345	COG0006	proline dipeptidase activity
I2T84_RS14360	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I2T84_RS14365	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I2T84_RS14380	COG4106	trans-aconitate 2-methyltransferase activity
I2T84_RS14395	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I2T84_RS14410	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I2T84_RS14460	COG0701	Predicted permease
I2T84_RS14485	COG2272	Belongs to the type-B carboxylesterase lipase family
I2T84_RS14525	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I2T84_RS14535	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I2T84_RS14545	COG0747	negative chemotaxis
I2T84_RS14550	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I2T84_RS14565	COG2255	four-way junction helicase activity
I2T84_RS14575	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
I2T84_RS14610	COG1946	Acyl-CoA thioesterase
I2T84_RS14615	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
I2T84_RS14625	COG0438	transferase activity, transferring glycosyl groups
I2T84_RS14665	COG4762	Protein conserved in bacteria
I2T84_RS14700	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I2T84_RS14720	COG4585	Histidine kinase
I2T84_RS14775	COG3831	ATPase activity
I2T84_RS14780	COG0714	Associated with various cellular activities
I2T84_RS14785	COG2425	protein containing a von Willebrand factor type A (vWA) domain
I2T84_RS14790	COG3552	Protein containing von Willebrand factor type A (VWA) domain
I2T84_RS14795	COG4715	Zinc finger, swim domain protein
I2T84_RS14815	COG0328	RNA-DNA hybrid ribonuclease activity
I2T84_RS14895	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I2T84_RS14940	COG5651	PPE family
I2T84_RS14970	COG1061	Type III restriction enzyme res subunit
I2T84_RS14975	COG1481	regulation of sporulation
I2T84_RS15005	COG1481	regulation of sporulation
I2T84_RS15110	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I2T84_RS15140	COG1674	ftsk spoiiie
I2T84_RS15155	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
I2T84_RS15250	COG3547	Transposase (IS116 IS110 IS902 family)
I2T84_RS15695	COG2124	cytochrome p450
I2T84_RS15760	COG0328	RNA-DNA hybrid ribonuclease activity
I2T84_RS15765	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
I2T84_RS15765	COG1793	dna ligase
I2T84_RS15905	COG3878	Protein conserved in bacteria
I2T84_RS15955	COG1404	Belongs to the peptidase S8 family
I2T84_RS16050	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
I2T84_RS16140	COG1192	Involved in chromosome partitioning
I2T84_RS16455	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I2T84_RS16470	COG2080	2 iron, 2 sulfur cluster binding
I2T84_RS16470	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I2T84_RS16485	COG0402	S-adenosylhomocysteine deaminase activity
I2T84_RS16505	COG2233	PERMEase
I2T84_RS16525	COG1953	Uracil, thiamine, allantoin
I2T84_RS16535	COG1301	dicarboxylic acid transport
I2T84_RS16545	COG4266	Belongs to the allantoicase family
I2T84_RS16555	COG0596	Alpha beta hydrolase
I2T84_RS16570	COG0501	Belongs to the peptidase M48B family
I2T84_RS16585	COG0477	Major facilitator Superfamily
I2T84_RS16600	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
I2T84_RS16640	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I2T84_RS16650	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I2T84_RS16690	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I2T84_RS16715	COG3253	May function as heme-dependent peroxidase
I2T84_RS16720	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
I2T84_RS16725	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I2T84_RS16735	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
I2T84_RS16755	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I2T84_RS16760	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I2T84_RS16765	COG0531	amino acid
I2T84_RS16770	COG0569	domain protein
I2T84_RS16800	COG0702	epimerase
I2T84_RS16815	COG0756	dUTP diphosphatase activity
I2T84_RS16860	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I2T84_RS16905	COG3220	belongs to the UPF0276 family
I2T84_RS16980	COG1388	LysM domain
I2T84_RS16995	COG1960	acyl-CoA dehydrogenase activity
I2T84_RS17005	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I2T84_RS17025	COG1196	nuclear chromosome segregation
I2T84_RS17045	COG1126	abc transporter atp-binding protein
I2T84_RS17050	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I2T84_RS17055	COG0765	amino acid transport
I2T84_RS17060	COG0765	amino acid transport
I2T84_RS17110	COG4308	Limonene-1,2-epoxide hydrolase catalytic domain
I2T84_RS17115	COG4308	Limonene-1,2-epoxide hydrolase catalytic domain
I2T84_RS17130	COG1842	Phage shock protein A
I2T84_RS17135	COG1396	sequence-specific DNA binding
I2T84_RS17145	COG1028	Short-chain dehydrogenase reductase Sdr
I2T84_RS17155	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I2T84_RS17210	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I2T84_RS17215	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I2T84_RS17230	COG3214	Protein conserved in bacteria
I2T84_RS17280	COG0659	secondary active sulfate transmembrane transporter activity
I2T84_RS17290	COG0686	Belongs to the AlaDH PNT family
I2T84_RS17375	COG2977	Belongs to the P-Pant transferase superfamily
I2T84_RS17380	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I2T84_RS17400	COG1960	acyl-CoA dehydrogenase activity
I2T84_RS17405	COG1960	acyl-CoA dehydrogenase activity
I2T84_RS17410	COG1024	Enoyl-CoA hydratase
I2T84_RS17435	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I2T84_RS17460	COG1017	nitric oxide dioxygenase activity
I2T84_RS17460	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I2T84_RS17465	COG1959	2 iron, 2 sulfur cluster binding
I2T84_RS17510	COG1648	precorrin-2 dehydrogenase activity
I2T84_RS17510	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I2T84_RS17535	COG3321	synthase
I2T84_RS17535	COG1028	Short-chain dehydrogenase reductase Sdr
I2T84_RS17535	COG0604	alcohol dehydrogenase
I2T84_RS17600	COG0579	oxidoreductase
I2T84_RS17620	COG1492	cobalamin metabolic process
I2T84_RS17630	COG1376	ErfK ybiS ycfS ynhG family protein
I2T84_RS17655	COG0750	zinc metalloprotease
I2T84_RS17680	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I2T84_RS17720	COG0412	Dienelactone hydrolase
I2T84_RS17745	COG0528	UMP kinase activity
I2T84_RS17750	COG3973	AAA domain
I2T84_RS17765	COG2723	6-phospho-beta-galactosidase activity
I2T84_RS17800	COG1309	transcriptional regulator
I2T84_RS17840	COG0583	DNA-binding transcription factor activity
I2T84_RS17865	COG0792	nuclease activity
I2T84_RS17945	COG0336	Belongs to the RNA methyltransferase TrmD family
I2T84_RS17985	COG1686	Belongs to the peptidase S11 family
I2T84_RS18005	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I2T84_RS18025	COG1304	FMN binding
I2T84_RS18050	COG1254	Belongs to the acylphosphatase family
I2T84_RS18075	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
I2T84_RS18080	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
I2T84_RS18100	COG0571	ribonuclease III activity
I2T84_RS18110	COG3599	regulation of cell shape
I2T84_RS18155	COG0742	ribosomal rna small subunit methyltransferase
I2T84_RS18160	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
I2T84_RS18175	COG0657	acetylesterase activity
I2T84_RS18180	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I2T84_RS18200	COG2124	cytochrome p450
I2T84_RS18215	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I2T84_RS18220	COG1461	Dihydroxyacetone kinase
I2T84_RS18230	COG1024	Enoyl-CoA hydratase
I2T84_RS18255	COG1181	Belongs to the D-alanine--D-alanine ligase family
I2T84_RS18260	COG0626	cystathionine gamma-synthase activity
I2T84_RS18265	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I2T84_RS18345	COG0179	Fumarylacetoacetate (FAA) hydrolase
I2T84_RS18360	COG2271	Major facilitator Superfamily
I2T84_RS18395	COG0583	DNA-binding transcription factor activity
I2T84_RS18405	COG0778	Nitroreductase
I2T84_RS18420	COG1309	transcriptional regulator
I2T84_RS18425	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I2T84_RS18430	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I2T84_RS18435	COG2124	cytochrome p450
I2T84_RS18510	COG0440	acetolactate synthase activity
I2T84_RS18525	COG1748	Saccharopine dehydrogenase
I2T84_RS18530	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I2T84_RS18550	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I2T84_RS18570	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I2T84_RS18580	COG2272	Belongs to the type-B carboxylesterase lipase family
I2T84_RS18595	COG0745	RESPONSE REGULATOR receiver
I2T84_RS18600	COG2205	protein histidine kinase activity
I2T84_RS18625	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I2T84_RS18655	COG1024	Enoyl-CoA hydratase
I2T84_RS18660	COG0778	Nitroreductase
I2T84_RS18670	COG2252	PERMEase
I2T84_RS18710	COG2197	response regulator
I2T84_RS18715	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I2T84_RS18725	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I2T84_RS18750	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I2T84_RS18765	COG1309	transcriptional regulator
I2T84_RS18795	COG0110	maltose O-acetyltransferase activity
I2T84_RS18800	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I2T84_RS18825	COG1119	ATPase activity
I2T84_RS18835	COG2364	Membrane
I2T84_RS18840	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I2T84_RS18855	COG4607	ABC-type enterochelin transport system periplasmic component
I2T84_RS18905	COG1064	alcohol dehydrogenase
I2T84_RS18925	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I2T84_RS18930	COG1028	Short-chain dehydrogenase reductase Sdr
I2T84_RS19005	COG0477	Major facilitator Superfamily
I2T84_RS19025	COG1028	Short-chain dehydrogenase reductase Sdr
I2T84_RS19055	COG1028	Short-chain dehydrogenase reductase Sdr
I2T84_RS19080	COG1335	isochorismatase
I2T84_RS19090	COG2855	membrane
I2T84_RS19100	COG0318	PFAM AMP-dependent synthetase and ligase
I2T84_RS19115	COG1028	Short-chain dehydrogenase reductase Sdr
I2T84_RS19125	COG1028	Short-chain dehydrogenase reductase Sdr
I2T84_RS19130	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I2T84_RS19190	COG2272	Belongs to the type-B carboxylesterase lipase family
I2T84_RS19195	COG2272	Belongs to the type-B carboxylesterase lipase family
I2T84_RS19205	COG0183	Belongs to the thiolase family
I2T84_RS19240	COG1309	transcriptional regulator
I2T84_RS19270	COG0789	Transcriptional regulator
I2T84_RS19280	COG0028	Belongs to the TPP enzyme family
I2T84_RS19305	COG2177	Part of the ABC transporter FtsEX involved in
I2T84_RS19310	COG2884	Cell division ATP-binding protein ftsE
I2T84_RS19320	COG0668	transmembrane transport
I2T84_RS19360	COG0483	inositol monophosphate 1-phosphatase activity
I2T84_RS19365	COG1960	acyl-CoA dehydrogenase activity
I2T84_RS19370	COG1960	acyl-CoA dehydrogenase activity
I2T84_RS19385	COG0318	PFAM AMP-dependent synthetase and ligase
I2T84_RS19395	COG0542	response to heat
I2T84_RS19440	COG3480	Lon protease (S16) C-terminal proteolytic domain
I2T84_RS19445	COG3011	Protein conserved in bacteria
I2T84_RS19460	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I2T84_RS19465	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I2T84_RS19470	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I2T84_RS19505	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I2T84_RS19505	COG0475	glutathione-regulated potassium exporter activity
I2T84_RS19520	COG0596	Alpha beta hydrolase
I2T84_RS19535	COG0745	RESPONSE REGULATOR receiver
I2T84_RS19545	COG2146	nitrite reductase [NAD(P)H] activity
I2T84_RS19545	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I2T84_RS19550	COG2223	nitrite transmembrane transporter activity
I2T84_RS19590	COG0513	Belongs to the DEAD box helicase family
I2T84_RS19605	COG0406	alpha-ribazole phosphatase activity
I2T84_RS19615	COG0456	acetyltransferase
I2T84_RS19625	COG1597	lipid kinase activity
I2T84_RS19640	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
I2T84_RS19650	COG1595	DNA-templated transcription, initiation
I2T84_RS19660	COG2135	peptidase activity
I2T84_RS19665	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I2T84_RS19670	COG1162	GTPase activity
I2T84_RS19705	COG1309	transcriptional regulator
I2T84_RS19710	COG0653	protein targeting
I2T84_RS19720	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I2T84_RS19725	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I2T84_RS19735	COG1309	transcriptional regulator
I2T84_RS19750	COG5401	PFAM Sporulation and spore germination
I2T84_RS19755	COG5002	protein histidine kinase activity
I2T84_RS19765	COG0318	PFAM AMP-dependent synthetase and ligase
I2T84_RS19770	COG1285	pathogenesis
I2T84_RS19810	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I2T84_RS19815	COG0531	amino acid
I2T84_RS19825	COG1482	cell wall glycoprotein biosynthetic process
I2T84_RS19855	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I2T84_RS19860	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
I2T84_RS19860	COG0778	Nitroreductase
I2T84_RS19875	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I2T84_RS19890	COG1316	TRANSCRIPTIONal
I2T84_RS19910	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I2T84_RS19920	COG2175	clavaminate synthase activity
I2T84_RS19945	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
I2T84_RS19945	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
I2T84_RS19970	COG1309	transcriptional regulator
I2T84_RS19995	COG0582	viral genome integration into host DNA
I2T84_RS20025	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I2T84_RS20035	COG0424	maF-like protein
I2T84_RS20050	COG2226	methyltransferase
I2T84_RS20060	COG3265	gluconokinase activity
I2T84_RS20080	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I2T84_RS20090	COG1733	regulation of RNA biosynthetic process
I2T84_RS20115	COG4770	biotin carboxylase activity
I2T84_RS20150	COG1012	belongs to the aldehyde dehydrogenase family
I2T84_RS20155	COG1309	transcriptional regulator
I2T84_RS20160	COG1201	RNA secondary structure unwinding
I2T84_RS20175	COG0564	pseudouridine synthase activity
I2T84_RS20195	COG1473	amidohydrolase
I2T84_RS20195	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
I2T84_RS20210	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I2T84_RS20225	COG3883	PFAM NLP P60 protein
I2T84_RS20225	COG0791	NLP P60 protein
I2T84_RS20270	COG2009	succinate dehydrogenase
I2T84_RS20285	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I2T84_RS20290	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I2T84_RS20295	COG1595	DNA-templated transcription, initiation
I2T84_RS20305	COG1686	Belongs to the peptidase S11 family
I2T84_RS20320	COG0708	Exodeoxyribonuclease III
I2T84_RS20380	COG1733	regulation of RNA biosynthetic process
I2T84_RS20385	COG2910	NAD(P)H-binding
I2T84_RS20390	COG1131	(ABC) transporter
I2T84_RS20390	COG1716	ATPase activity
I2T84_RS20390	COG0842	Transport permease protein
I2T84_RS20395	COG1357	PFAM Pentapeptide repeats (8 copies)
I2T84_RS20400	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I2T84_RS20415	COG1309	transcriptional regulator
I2T84_RS20480	COG0519	Catalyzes the synthesis of GMP from XMP
I2T84_RS20480	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I2T84_RS20490	COG0516	GMP reductase activity
I2T84_RS20535	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I2T84_RS20550	COG0456	acetyltransferase
I2T84_RS20570	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I2T84_RS20575	COG0076	glutamate decarboxylase activity
I2T84_RS20585	COG2267	carboxylic ester hydrolase activity
I2T84_RS20590	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I2T84_RS20615	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I2T84_RS20625	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I2T84_RS20630	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I2T84_RS20665	COG1404	Belongs to the peptidase S8 family
I2T84_RS20695	COG2267	carboxylic ester hydrolase activity
I2T84_RS20750	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I2T84_RS20755	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I2T84_RS20765	COG2268	Band 7 protein
I2T84_RS20775	COG1088	dTDP-glucose 4,6-dehydratase activity
I2T84_RS20780	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
I2T84_RS20825	COG0616	signal peptide processing
I2T84_RS20840	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I2T84_RS20860	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I2T84_RS20870	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I2T84_RS20880	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I2T84_RS20895	COG2272	Belongs to the type-B carboxylesterase lipase family
I2T84_RS20920	COG0477	Major facilitator Superfamily
I2T84_RS20935	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I2T84_RS20950	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I2T84_RS20975	COG0088	Forms part of the polypeptide exit tunnel
I2T84_RS20980	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I2T84_RS20985	COG0051	transcription antitermination factor activity, RNA binding
I2T84_RS20990	COG0259	pyridoxamine-phosphate oxidase activity
I2T84_RS21020	COG0531	amino acid
I2T84_RS21050	COG0535	radical SAM domain protein
I2T84_RS21075	COG1834	amidinotransferase
I2T84_RS21080	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I2T84_RS21085	COG0531	amino acid
I2T84_RS21130	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I2T84_RS21135	COG1309	transcriptional regulator
I2T84_RS21160	COG1024	Enoyl-CoA hydratase
I2T84_RS21175	COG1960	acyl-CoA dehydrogenase activity
I2T84_RS21205	COG1113	amino acid transport
I2T84_RS21220	COG0085	RNA polymerase activity
I2T84_RS21225	COG0243	molybdopterin cofactor binding
I2T84_RS21280	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I2T84_RS21295	COG0277	FAD linked oxidase domain protein
I2T84_RS21315	COG4941	Belongs to the sigma-70 factor family
I2T84_RS21350	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I2T84_RS21390	COG0783	Belongs to the Dps family
I2T84_RS21395	COG0693	protein deglycase activity
I2T84_RS21440	COG1404	Belongs to the peptidase S8 family
I2T84_RS21460	COG1280	lysine exporter protein (LysE YggA)
I2T84_RS21530	COG0501	Belongs to the peptidase M48B family
I2T84_RS21535	COG0142	geranyltranstransferase activity
I2T84_RS21540	COG0644	oxidoreductase
I2T84_RS21550	COG0438	transferase activity, transferring glycosyl groups
I2T84_RS21570	COG4948	Mandelate Racemase Muconate Lactonizing
I2T84_RS21590	COG3706	GGDEF domain
I2T84_RS21605	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I2T84_RS21615	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I2T84_RS21620	COG1028	Short-chain dehydrogenase reductase Sdr
I2T84_RS21685	COG3723	Recombinational DNA repair protein, rece pathway
I2T84_RS21945	COG4974	Belongs to the 'phage' integrase family
I2T84_RS21950	COG4221	oxidoreductase activity
I2T84_RS22000	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
I2T84_RS22005	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I2T84_RS22040	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I2T84_RS22085	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I2T84_RS22095	COG0785	Cytochrome C biogenesis protein
I2T84_RS22100	COG0386	Belongs to the glutathione peroxidase family
I2T84_RS22105	COG0406	alpha-ribazole phosphatase activity
I2T84_RS22120	COG3590	peptidase
I2T84_RS22170	COG1648	precorrin-2 dehydrogenase activity
I2T84_RS22170	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I2T84_RS22195	COG2030	dehydratase
I2T84_RS22220	COG2070	2-Nitropropane dioxygenase
I2T84_RS22245	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I2T84_RS22250	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I2T84_RS22335	COG2072	flavoprotein involved in K transport
I2T84_RS22360	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I2T84_RS22410	COG2072	flavoprotein involved in K transport
I2T84_RS22425	COG2072	flavoprotein involved in K transport
I2T84_RS22430	COG1028	Short-chain dehydrogenase reductase Sdr
I2T84_RS22435	COG0657	acetylesterase activity
I2T84_RS22440	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I2T84_RS22450	COG0745	RESPONSE REGULATOR receiver
I2T84_RS22455	COG5002	protein histidine kinase activity
I2T84_RS22465	COG2072	flavoprotein involved in K transport
I2T84_RS22480	COG0300	oxidoreductase activity
I2T84_RS22535	COG2814	Major facilitator Superfamily
I2T84_RS22540	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I2T84_RS22635	COG2733	membrane
I2T84_RS22645	COG2326	polyphosphate kinase activity
I2T84_RS22650	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I2T84_RS22685	COG2224	Isocitrate lyase
I2T84_RS22725	COG2226	methyltransferase
I2T84_RS22775	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I2T84_RS22810	COG0667	Aldo Keto reductase
I2T84_RS22835	COG4552	Acetyltransferase involved in intracellular survival and related
I2T84_RS22840	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I2T84_RS22865	COG1505	serine-type exopeptidase activity
I2T84_RS22885	COG1073	alpha beta
I2T84_RS22890	COG2326	polyphosphate kinase activity
I2T84_RS22905	COG2223	nitrite transmembrane transporter activity
I2T84_RS22910	COG0640	Transcriptional regulator
I2T84_RS22940	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
I2T84_RS22960	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I2T84_RS22985	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I2T84_RS22995	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I2T84_RS23000	COG1028	Short-chain dehydrogenase reductase Sdr
I2T84_RS23010	COG1960	acyl-CoA dehydrogenase activity
I2T84_RS23015	COG1960	acyl-CoA dehydrogenase activity
I2T84_RS23020	COG0318	PFAM AMP-dependent synthetase and ligase
I2T84_RS23030	COG2070	2-Nitropropane dioxygenase
I2T84_RS23040	COG1024	Enoyl-CoA hydratase
I2T84_RS23045	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I2T84_RS23050	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I2T84_RS23085	COG4638	Rieske (2fe-2S)
I2T84_RS23125	COG0175	sulfate reduction
I2T84_RS23195	COG2814	Major facilitator Superfamily
I2T84_RS23205	COG0351	phosphomethylpyrimidine kinase
I2T84_RS23215	COG1252	NADH dehydrogenase
I2T84_RS23225	COG1309	transcriptional regulator
I2T84_RS23235	COG1012	belongs to the aldehyde dehydrogenase family
I2T84_RS23270	COG0494	nUDIX hydrolase
I2T84_RS23280	COG2234	aminopeptidase activity
I2T84_RS23285	COG2234	aminopeptidase activity
I2T84_RS23295	COG1131	(ABC) transporter
I2T84_RS23300	COG2022	thiamine diphosphate biosynthetic process
I2T84_RS23335	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I2T84_RS23340	COG0515	serine threonine protein kinase
I2T84_RS23345	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I2T84_RS23375	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I2T84_RS23380	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I2T84_RS23385	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I2T84_RS23390	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I2T84_RS23400	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I2T84_RS23405	COG1126	abc transporter atp-binding protein
I2T84_RS23410	COG0765	amino acid transport
I2T84_RS23445	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
I2T84_RS23470	COG0415	Belongs to the DNA photolyase family
I2T84_RS23475	COG1090	epimerase
I2T84_RS23485	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I2T84_RS23500	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I2T84_RS23535	COG1994	Peptidase M50
I2T84_RS23555	COG0586	Pfam SNARE associated Golgi protein
I2T84_RS23585	COG4221	oxidoreductase activity
I2T84_RS23605	COG0542	response to heat
I2T84_RS23625	COG0789	Transcriptional regulator
I2T84_RS23635	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ