locus-tag class description G6N34_RS00010 ENOG4105SKE transcriptional Regulator LysR family G6N34_RS00015 ENOG4105C57 major facilitator superfamily G6N34_RS00020 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) G6N34_RS00025 ENOG4105DEF Extracellular solute-binding protein, family 5 G6N34_RS00030 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component G6N34_RS00035 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component G6N34_RS00040 ENOG4108JQ6 ABC transporter G6N34_RS00095 ENOG4108I5C dEAD DEAH box helicase G6N34_RS00100 ENOG4105VEQ Cold shock protein G6N34_RS00110 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) G6N34_RS00120 ENOG4107QRG dna polymerase iii G6N34_RS00130 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase G6N34_RS00155 ENOG4108PBI Polysaccharide metabolism G6N34_RS00205 ENOG4107RD1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) G6N34_RS00215 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) G6N34_RS00225 ENOG4105D74 hydrolase G6N34_RS00230 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) G6N34_RS00235 ENOG4105EUJ GTP cyclohydrolase i G6N34_RS00240 ENOG4105EEI dihydropteroate synthase G6N34_RS00270 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) G6N34_RS00275 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) G6N34_RS00280 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) G6N34_RS00290 ENOG4105CRK lysyL-tRNA synthetase G6N34_RS00300 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit G6N34_RS00345 ENOG4105DXX methyltransferase G6N34_RS00350 ENOG4105CEN a g-specific adenine glycosylase G6N34_RS00365 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) G6N34_RS00370 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) G6N34_RS00380 ENOG4108VJ1 Transcriptional regulator (CarD family G6N34_RS00385 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) G6N34_RS00390 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) G6N34_RS00395 ENOG4105C8N cysteinyl-tRNA synthetase G6N34_RS00400 ENOG4105C2N RNA methyltransferase TrmH family group 3 G6N34_RS00420 ENOG4105DSE periplasmic solute binding protein G6N34_RS00425 ENOG4105DIK (ABC) transporter G6N34_RS00430 ENOG4105CC5 ABC transporter G6N34_RS00445 ENOG4108SGK Tetr family transcriptional regulator G6N34_RS00450 ENOG4105D2B acyl-CoA dehydrogenase G6N34_RS00460 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) G6N34_RS00510 ENOG4105D2B acyl-CoA dehydrogenase G6N34_RS00515 ENOG4105D2B acyl-CoA dehydrogenase G6N34_RS00520 ENOG4105CC9 acyl-Coa dehydrogenase G6N34_RS00525 ENOG4105CEY Amp-dependent synthetase and ligase G6N34_RS00530 ENOG4105CC9 acyl-Coa dehydrogenase G6N34_RS00555 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase G6N34_RS00560 ENOG4108RZE Tetr family transcriptional regulator G6N34_RS00565 ENOG4105F2C Acetyl-CoA acetyltransferase G6N34_RS00585 ENOG4105EA8 2-Nitropropane dioxygenase G6N34_RS00600 ENOG4105E39 Enoyl-CoA hydratase G6N34_RS00620 ENOG4105GCF PGAM G6N34_RS00635 ENOG4105F2C Acetyl-CoA acetyltransferase G6N34_RS00645 ENOG4108RK3 acyl-Coa dehydrogenase G6N34_RS00650 ENOG4105X7H acyl-CoA dehydrogenase G6N34_RS00655 ENOG410900P UPF0336 protein G6N34_RS00680 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein G6N34_RS00685 ENOG4105IKQ hydratase G6N34_RS00690 ENOG4105DIV Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD( ) and coenzyme A. Is the final enzyme in the meta- cleavage pathway for the degradation of aromatic compounds (By similarity) G6N34_RS00695 ENOG4105DF3 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity) G6N34_RS00700 ENOG4105C9U ATP-dependent DNA helicase RecQ G6N34_RS00760 ENOG4105CYX Short-chain dehydrogenase reductase Sdr G6N34_RS00780 ENOG4105CIJ rieske 2fe-2S domain-containing protein G6N34_RS00790 ENOG4105X1P Steroid delta-isomerase G6N34_RS00800 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) G6N34_RS00815 ENOG4105DYW oxidoreductase G6N34_RS00825 ENOG410719E cytochrome p450 G6N34_RS00835 ENOG4105E39 Enoyl-CoA hydratase G6N34_RS00855 ENOG4105J5T Amp-dependent synthetase and ligase G6N34_RS00860 ENOG4108KC2 acyl-Coa dehydrogenase G6N34_RS00865 ENOG4105X7H acyl-CoA dehydrogenase G6N34_RS00875 ENOG4105CHR reductase G6N34_RS00930 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase G6N34_RS00950 ENOG4106KE4 Dehydrogenase G6N34_RS00960 ENOG4105DNH Major Facilitator G6N34_RS00965 ENOG4105C7R Atpase associated with various cellular activities aaa_3 G6N34_RS01020 ENOG4105CK6 Two component transcriptional regulator (Winged helix family G6N34_RS01025 ENOG4105BZU Histidine kinase G6N34_RS01050 ENOG41068W2 Cytochrome p-450 G6N34_RS01055 ENOG4105EMU Dehydrogenase G6N34_RS01070 ENOG4105C26 Dehydrogenase G6N34_RS01095 ENOG4108R85 Short chain dehydrogenase G6N34_RS01105 ENOG4105H3G oxidoreductase G6N34_RS01120 ENOG41076PI Short-chain dehydrogenase reductase Sdr G6N34_RS01125 ENOG4105C1G acyl-Coa dehydrogenase G6N34_RS01140 ENOG4105C1G acyl-Coa dehydrogenase G6N34_RS01145 ENOG4108WYP Transcriptional regulator G6N34_RS01150 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G6N34_RS01155 ENOG4105CEY Amp-dependent synthetase and ligase G6N34_RS01160 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase G6N34_RS01165 ENOG4105CEY Amp-dependent synthetase and ligase G6N34_RS01170 ENOG4108UKI Enoyl-CoA hydratase G6N34_RS01185 ENOG41073TP transcriptional regulator G6N34_RS01190 ENOG4105E39 Enoyl-CoA hydratase G6N34_RS01215 ENOG4105CGU Enoyl-CoA hydratase G6N34_RS01240 ENOG4105X7H acyl-CoA dehydrogenase G6N34_RS01265 ENOG4107RGH Aldehyde dehydrogenase G6N34_RS01290 ENOG4107S2E monooxygenase G6N34_RS01315 ENOG4107QX3 carboxylase G6N34_RS01345 ENOG4105CUB amino acid G6N34_RS01355 ENOG4105C83 adenylosuccinate lyase G6N34_RS01380 ENOG4108V06 Glutathione peroxidase G6N34_RS01400 ENOG41076PI Short-chain dehydrogenase reductase Sdr G6N34_RS01415 ENOG410839H phosphoribosylformylglycinamidine synthase G6N34_RS01430 ENOG4105EMU Dehydrogenase G6N34_RS01445 ENOG4105EZR dyp-type peroxidase family protein G6N34_RS01450 ENOG4105DFM M18 family aminopeptidase G6N34_RS01460 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii G6N34_RS01505 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component G6N34_RS01510 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component G6N34_RS01520 ENOG4105CGD Nad-dependent epimerase dehydratase G6N34_RS01525 ENOG4105CXB phosphoribosylaminoimidazole synthetase G6N34_RS01555 ENOG4105PKJ carbohydrate binding G6N34_RS01560 ENOG4105KHC sulfurtransferase G6N34_RS01580 ENOG4107NHD transcriptional regulator G6N34_RS01585 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) G6N34_RS01600 ENOG4105E2Z phosphate ABC transporter (Permease G6N34_RS01605 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) G6N34_RS01640 ENOG4105D9P serine threonine protein kinase G6N34_RS01675 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) G6N34_RS01695 ENOG4105FDP GntR family transcriptional regulator G6N34_RS01720 ENOG4105D5G Transposase G6N34_RS01800 ENOG4108WYP Transcriptional regulator G6N34_RS01805 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease G6N34_RS01830 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone G6N34_RS01840 ENOG4105CHU acetyl-coa acetyltransferase G6N34_RS01845 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase G6N34_RS01875 ENOG4105CHU acetyl-coa acetyltransferase G6N34_RS01890 ENOG4105CFI type iii restriction protein res subunit G6N34_RS01910 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) G6N34_RS01935 ENOG410901E Membrane G6N34_RS01940 ENOG4105VEQ Cold shock protein G6N34_RS01945 ENOG4105CHF Glutathione S-transferase G6N34_RS01960 ENOG4108N0W Major Facilitator superfamily G6N34_RS01995 ENOG4107R8H Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) G6N34_RS02025 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) G6N34_RS02050 ENOG4108US0 Transcription regulator that can specifically activate or repress expression of target genes (By similarity) G6N34_RS02065 ENOG41081K0 peptidylprolyl cis-trans isomerase G6N34_RS02085 ENOG4105BZ1 (ABC) transporter G6N34_RS02090 ENOG4105BZ1 (ABC) transporter G6N34_RS02100 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) G6N34_RS02105 ENOG4105CEY Amp-dependent synthetase and ligase G6N34_RS02135 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic G6N34_RS02160 ENOG4107QRI Phosphoketolase G6N34_RS02175 ENOG4105C5H ABC transporter G6N34_RS02210 ENOG4108IIZ The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane G6N34_RS02215 ENOG4105CI1 PTS System G6N34_RS02220 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) G6N34_RS02225 ENOG4105CE4 GlcNAc 6-P deacetylase G6N34_RS02260 ENOG4106PVI ATP-dependent carboxylate-amine ligase (By similarity) G6N34_RS02270 ENOG4105K6V RNA polymerase G6N34_RS02280 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase G6N34_RS02330 ENOG41061H0 Monooxygenase G6N34_RS02340 ENOG4105FDF Could be involved in DNA repair (By similarity) G6N34_RS02350 ENOG4105DQE DNA ligase G6N34_RS02375 ENOG4105FP9 thiamine pyrophosphate G6N34_RS02385 ENOG4105CQB FAD linked oxidase domain protein G6N34_RS02395 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase G6N34_RS02400 ENOG4105WSE Subunit of malonate decarboxylase, it is an acyl carrier protein to which acetyl and malonyl thioester residues are bound via a 2'-(5''-phosphoribosyl)-3'-dephospho-CoA prosthetic group and turn over during the catalytic mechanism (By similarity) G6N34_RS02415 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase G6N34_RS02420 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) G6N34_RS02440 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) G6N34_RS02490 ENOG4105F8J Adenylate Guanylate cyclase G6N34_RS02500 ENOG4107QP8 phosphohexose isomerase G6N34_RS02535 ENOG4105CMV Succinyl-CoA synthetase subunit beta G6N34_RS02570 ENOG4105FBW Monooxygenase G6N34_RS02625 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase G6N34_RS02660 ENOG4107QX3 carboxylase G6N34_RS02675 ENOG41067C8 50S ribosomal protein L32 G6N34_RS02680 ENOG4105ETX regulatoR G6N34_RS02695 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) G6N34_RS02740 ENOG41080UU 5-formyltetrahydrofolate cyclo-ligase G6N34_RS02745 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase G6N34_RS02795 ENOG4105FUY alpha subunit G6N34_RS02800 ENOG4105CHR reductase G6N34_RS02825 ENOG4105DVW rieske (2Fe-2S) G6N34_RS02830 ENOG4107XI7 Tetr family transcriptional regulator G6N34_RS02835 ENOG410870F Cyclic nucleotide-binding protein G6N34_RS02840 ENOG4105F9E Shikimate 5-dehydrogenase G6N34_RS02850 ENOG4105KAV tspo and mbr like protein G6N34_RS02875 ENOG4108Z4X TRANSCRIPTIONal G6N34_RS02880 ENOG4105CEU Arginine dihydrolase G6N34_RS02900 ENOG4105CRQ synthase (Component I) G6N34_RS02910 ENOG4108EQM faD-dependent pyridine nucleotide-disulfide oxidoreductase G6N34_RS02915 ENOG4105D82 Glutamate dehydrogenase G6N34_RS02925 ENOG4105F8V Hydrolase, tatD family G6N34_RS02930 ENOG4106839 domain protein G6N34_RS02935 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) G6N34_RS02940 ENOG4105D9P serine threonine protein kinase G6N34_RS02945 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) G6N34_RS02950 ENOG4107RCI amp-dependent synthetase and ligase G6N34_RS02955 ENOG4105D5Q Arginine ornithine antiporter G6N34_RS02965 ENOG4105C6F GntR Family Transcriptional Regulator G6N34_RS02970 ENOG4105CHR reductase G6N34_RS02975 ENOG4107REC cytoplasmic protein G6N34_RS02990 ENOG4105CFQ glutamine synthetase G6N34_RS03010 ENOG4107RN6 Monooxygenase G6N34_RS03015 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) G6N34_RS03050 ENOG4105BZU Histidine kinase G6N34_RS03055 ENOG4105WH1 Two component transcriptional regulator luxr family G6N34_RS03065 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) G6N34_RS03125 ENOG4108ZXC Two component transcriptional regulator, luxr family G6N34_RS03130 ENOG4105DXN mazG family G6N34_RS03135 ENOG4105DBE peroxidase G6N34_RS03140 ENOG410650H (LipO)protein G6N34_RS03155 ENOG4107SQD Transcriptional regulator, GntR family G6N34_RS03165 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) G6N34_RS03195 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) G6N34_RS03200 ENOG41080HI glycine oxidase G6N34_RS03230 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) G6N34_RS03235 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) G6N34_RS03340 ENOG4108UQS dipeptidase G6N34_RS03350 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) G6N34_RS03380 ENOG4105C85 amino acid G6N34_RS03395 ENOG4105CSU acyl-Coa dehydrogenase G6N34_RS03400 ENOG4105DER m42 family G6N34_RS03425 ENOG4106A3M Cytochrome p-450 G6N34_RS03475 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein G6N34_RS03510 ENOG41062IE glyoxalase bleomycin resistance protein dioxygenase G6N34_RS03515 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component G6N34_RS03520 ENOG4105E2Y ABC, transporter G6N34_RS03550 ENOG4108IYU L-aspartate oxidase G6N34_RS03560 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component G6N34_RS03610 ENOG4105E5Q amino acid AbC transporter G6N34_RS03615 ENOG4105CDA abc transporter atp-binding protein G6N34_RS03635 ENOG4105CEY Amp-dependent synthetase and ligase G6N34_RS03640 ENOG4108KR4 dihydrodipicolinate reductase G6N34_RS03700 ENOG4105CHU acetyl-coa acetyltransferase G6N34_RS03735 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) G6N34_RS03745 ENOG4105T1M mycothiol conjugate amidase mca G6N34_RS03755 ENOG4105C7Z Conserved Protein G6N34_RS03770 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) G6N34_RS03795 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) G6N34_RS03805 ENOG4108IAB Phoh family G6N34_RS03815 ENOG4108ZJ4 polysaccharide deacetylase G6N34_RS03830 ENOG4105CSH Transporter G6N34_RS03860 ENOG4105CHR reductase G6N34_RS03880 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) G6N34_RS03890 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) G6N34_RS03905 ENOG4105C3G gtp-binding protein G6N34_RS03910 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA G6N34_RS04005 ENOG4108W6C Dehydrogenase G6N34_RS04040 ENOG4105CHU acetyl-coa acetyltransferase G6N34_RS04050 ENOG410906A Beta-Ig-H3 fasciclin G6N34_RS04055 ENOG4108Z0R Transferase G6N34_RS04060 ENOG4105CGD Nad-dependent epimerase dehydratase G6N34_RS04070 ENOG4105E8G Major facilitator Superfamily G6N34_RS04075 ENOG4108UKI Enoyl-CoA hydratase G6N34_RS04085 ENOG4105KPY Small multidrug resistance protein G6N34_RS04100 ENOG4105EA8 2-Nitropropane dioxygenase G6N34_RS04110 ENOG4107R13 MMPL domain protein G6N34_RS04145 ENOG410905P Pyridoxamine 5-phosphate G6N34_RS04170 ENOG4107QN1 sodium solute G6N34_RS04190 ENOG4105DY9 regulatoR G6N34_RS04195 ENOG4108HRK Histidine kinase G6N34_RS04220 ENOG4108U8T Mannosyltransferase G6N34_RS04225 ENOG410842T Pterin carbinolamine dehydratase G6N34_RS04250 ENOG4108IUE nitrate reductase beta subunit G6N34_RS04280 ENOG4107USK Extracellular solute-binding protein, family 5 G6N34_RS04295 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) G6N34_RS04325 ENOG4108YYC ycei family G6N34_RS04330 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase G6N34_RS04340 ENOG4108Z4U Ferredoxin G6N34_RS04355 ENOG4105C26 Dehydrogenase G6N34_RS04360 ENOG41062BK proline dehydrogenase G6N34_RS04380 ENOG4105CEY Amp-dependent synthetase and ligase G6N34_RS04390 ENOG4105E7Q Cob(II)yrinic acid a,c-diamide reductase G6N34_RS04400 ENOG4107R4C succinyl-diaminopimelate desuccinylase G6N34_RS04410 ENOG4108URH decarboxylase G6N34_RS04420 ENOG4105EEI dihydropteroate synthase G6N34_RS04425 ENOG4105C3Q Glycosyl transferase, family 2 G6N34_RS04435 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) G6N34_RS04445 ENOG4107QPH glycogen) synthase G6N34_RS04450 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) G6N34_RS04465 ENOG4105DIM ABC transporter G6N34_RS04470 ENOG4105CIG ABC transporter G6N34_RS04475 ENOG4108X07 Tetr family transcriptional regulator G6N34_RS04485 ENOG4105DU6 RNA polymerase G6N34_RS04490 ENOG4106684 G6N34_RS04495 ENOG4105C0H protease G6N34_RS04500 ENOG4105UTW Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) G6N34_RS04520 ENOG4105CJW magnesium transporter G6N34_RS04570 ENOG4105D7N magnesium and cobalt transport protein CorA G6N34_RS04595 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 G6N34_RS04605 ENOG4105C2C drug resistance transporter, Bcr CflA G6N34_RS04660 ENOG4105CQB FAD linked oxidase domain protein G6N34_RS04690 ENOG4105DEN Luciferase family G6N34_RS04700 ENOG4105C5X domain protein G6N34_RS04715 ENOG4105XTG Pfam:DUF156 G6N34_RS04745 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) G6N34_RS04775 ENOG4108UZX fmn reductase G6N34_RS04790 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component G6N34_RS04795 ENOG4108JQ6 ABC transporter G6N34_RS04800 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) G6N34_RS04865 ENOG4107T8P acyl-Coa dehydrogenase G6N34_RS04900 ENOG4105C11 sulfate adenylyltransferase), subunit 2 G6N34_RS04960 ENOG4108M8W Monooxygenase G6N34_RS04965 ENOG4105DMF Dehydrogenase G6N34_RS04970 ENOG4105CG3 alpha amylase, catalytic region G6N34_RS05040 ENOG4105C75 arginyL-tRNA synthetase G6N34_RS05045 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) G6N34_RS05050 ENOG4105D6E homoserine dehydrogenase G6N34_RS05055 ENOG4107R5I Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) G6N34_RS05060 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) G6N34_RS05065 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) G6N34_RS05070 ENOG4108IG5 Transcriptional regulator G6N34_RS05075 ENOG4105J5T Amp-dependent synthetase and ligase G6N34_RS05085 ENOG4105VFB Binds the 23S rRNA (By similarity) G6N34_RS05090 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) G6N34_RS05095 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) G6N34_RS05105 ENOG4105ESV Glycosyl transferase, family 4 G6N34_RS05110 ENOG4105YV6 ATP synthase i G6N34_RS05115 ENOG4107RAZ it plays a direct role in the translocation of protons across the membrane (By similarity) G6N34_RS05120 ENOG410679R F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) G6N34_RS05125 ENOG4105V1A F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) G6N34_RS05130 ENOG4108T62 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) G6N34_RS05135 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) G6N34_RS05140 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) G6N34_RS05145 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) G6N34_RS05165 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) G6N34_RS05185 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) G6N34_RS05200 ENOG4105CSV Glutaminase G6N34_RS05210 ENOG4105CYV Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity) G6N34_RS05225 ENOG4105CHU acetyl-coa acetyltransferase G6N34_RS05250 ENOG4105WH1 Two component transcriptional regulator luxr family G6N34_RS05255 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) G6N34_RS05260 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) G6N34_RS05265 ENOG4108IUN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) G6N34_RS05270 ENOG4105F9V Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid G6N34_RS05290 ENOG4107RKP Nicotinate phosphoribosyltransferase G6N34_RS05295 ENOG4105KEN Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) G6N34_RS05305 ENOG4105KXX peptidase s58 dmpa G6N34_RS05330 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) G6N34_RS05335 ENOG4108RQ5 Beta-lactamase domain-containing protein G6N34_RS05340 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) G6N34_RS05345 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) G6N34_RS05430 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase G6N34_RS05445 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase G6N34_RS05450 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase G6N34_RS05455 ENOG4107EXU Short-chain dehydrogenase reductase Sdr G6N34_RS05475 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G6N34_RS05490 ENOG4105D2B acyl-CoA dehydrogenase G6N34_RS05495 ENOG4105CC9 acyl-Coa dehydrogenase G6N34_RS05530 ENOG4105CC9 acyl-Coa dehydrogenase G6N34_RS05535 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) G6N34_RS05545 ENOG4105CHR reductase G6N34_RS05570 ENOG41088YA Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives (By similarity) G6N34_RS05575 ENOG4105CHR reductase G6N34_RS05615 ENOG4105D2B acyl-CoA dehydrogenase G6N34_RS05620 ENOG4105CC9 acyl-Coa dehydrogenase G6N34_RS05640 ENOG4105DVW rieske (2Fe-2S) G6N34_RS05655 ENOG4105CHR reductase G6N34_RS05660 ENOG410846T CoA-transferase family III G6N34_RS05665 ENOG4105CHU acetyl-coa acetyltransferase G6N34_RS05670 ENOG4105C1G acyl-Coa dehydrogenase G6N34_RS05675 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) G6N34_RS05690 ENOG4106A3M Cytochrome p-450 G6N34_RS05695 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase G6N34_RS05700 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase G6N34_RS05750 ENOG4105CC9 acyl-Coa dehydrogenase G6N34_RS05775 ENOG4108IG5 Transcriptional regulator G6N34_RS05790 ENOG4105H9W Short-chain dehydrogenase reductase Sdr G6N34_RS05815 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G6N34_RS05820 ENOG4105CY3 ABC transporter, permease G6N34_RS05885 ENOG4105CEY Amp-dependent synthetase and ligase G6N34_RS05895 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein G6N34_RS05910 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase G6N34_RS05920 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein G6N34_RS05955 ENOG4107XZC Restriction modification system DNA (Specificity G6N34_RS05975 ENOG4105CVR type I restriction-modification system G6N34_RS06010 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein G6N34_RS06040 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) G6N34_RS06055 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G6N34_RS06060 ENOG4105E0T Short-chain dehydrogenase reductase Sdr G6N34_RS06070 ENOG41076PI Short-chain dehydrogenase reductase Sdr G6N34_RS06075 ENOG410719E cytochrome p450 G6N34_RS06090 ENOG4105E39 Enoyl-CoA hydratase G6N34_RS06100 ENOG4105CEY Amp-dependent synthetase and ligase G6N34_RS06140 ENOG4105EA8 2-Nitropropane dioxygenase G6N34_RS06145 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) G6N34_RS06150 ENOG4105C26 Dehydrogenase G6N34_RS06170 ENOG4105C1G acyl-Coa dehydrogenase G6N34_RS06175 ENOG4105DDR sarcosine oxidase (Beta subunit) G6N34_RS06205 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase G6N34_RS06215 ENOG4105F38 ABC transporter, permease G6N34_RS06220 ENOG4105D38 putrescine abc transporter G6N34_RS06225 ENOG4105DVW rieske (2Fe-2S) G6N34_RS06245 ENOG4108WKN secreted protein G6N34_RS06260 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) G6N34_RS06280 ENOG4107UBC ErfK ybiS ycfS ynhG family protein G6N34_RS06310 ENOG4105D7A ATP-binding protein G6N34_RS06315 ENOG4105EMU Dehydrogenase G6N34_RS06345 ENOG4107QX3 carboxylase G6N34_RS06355 ENOG4105C1G acyl-Coa dehydrogenase G6N34_RS06380 ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 G6N34_RS06400 ENOG4105C0R drug resistance transporter emrb qaca subfamily G6N34_RS06405 ENOG4107R3N Filamentation induced by cAMP protein fic G6N34_RS06455 ENOG4107YH6 single-stranded DNA-binding protein G6N34_RS06465 ENOG4105C7I Dehydrogenase G6N34_RS06500 ENOG4109057 G6N34_RS06505 ENOG4105C57 major facilitator superfamily G6N34_RS06510 ENOG4108JJA ABC, transporter G6N34_RS06530 ENOG4105MC2 DSBA oxidoreductase G6N34_RS06545 ENOG4105ETS cytosine purines uracil thiamine allantoin G6N34_RS06560 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) G6N34_RS06565 ENOG4107RUE extracellular solute-binding protein family 1 G6N34_RS06570 ENOG4105F38 ABC transporter, permease G6N34_RS06575 ENOG4105D38 putrescine abc transporter G6N34_RS06615 ENOG4108S8N class II Aldolase G6N34_RS06620 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) G6N34_RS06625 ENOG4105CH6 catalase G6N34_RS06630 ENOG4108RPX mosc domain containing protein G6N34_RS06650 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation G6N34_RS06670 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) G6N34_RS06675 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) G6N34_RS06720 ENOG4105F0H myo-inositol catabolism protein G6N34_RS06725 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) G6N34_RS06735 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) G6N34_RS06750 ENOG4105EDK PfkB domain protein G6N34_RS06765 ENOG41062B0 ABC transporter, permease G6N34_RS06770 ENOG4105C2J ABC transporter G6N34_RS06775 ENOG4105CF7 AraC family transcriptional regulator G6N34_RS06780 ENOG4105CPC Aldo Keto reductase G6N34_RS06805 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) G6N34_RS06820 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein G6N34_RS06825 ENOG4105DQU oxidoreductase, subunit beta G6N34_RS06830 ENOG41080AZ Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) G6N34_RS06835 ENOG4105ETE Transcriptional regulator (LacI family G6N34_RS06880 ENOG4105CPD ethanolamine ammonia-lyase G6N34_RS06885 ENOG4107FQ9 ethanolamine ammonia-lyase G6N34_RS06890 ENOG4105EG6 Saccharopine dehydrogenase G6N34_RS06900 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) G6N34_RS06905 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase G6N34_RS06930 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) G6N34_RS06935 ENOG4105C03 ribonuclease G6N34_RS06945 ENOG4105K46 50S ribosomal protein l27 G6N34_RS06950 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control G6N34_RS06955 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) G6N34_RS07000 ENOG4108RVA ribokinase G6N34_RS07030 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) G6N34_RS07050 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) G6N34_RS07055 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) G6N34_RS07060 ENOG4105CVJ phosphoglycerate mutase G6N34_RS07065 ENOG4108TZC G6N34_RS07080 ENOG4105KQC Competence protein G6N34_RS07135 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) G6N34_RS07160 ENOG4105CUB amino acid G6N34_RS07230 ENOG4105C9B Cysteine desulfurase G6N34_RS07235 ENOG4105ESN nucleotide-binding protein G6N34_RS07265 ENOG4105BZP glycoside hydrolase 15-related G6N34_RS07270 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) G6N34_RS07280 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein G6N34_RS07285 ENOG4108I5D sulfate abc transporter G6N34_RS07290 ENOG4105ECW sulfate abc transporter G6N34_RS07335 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) G6N34_RS07355 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase G6N34_RS07375 ENOG4105CEY Amp-dependent synthetase and ligase G6N34_RS07400 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) G6N34_RS07405 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) G6N34_RS07440 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) G6N34_RS07465 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) G6N34_RS07490 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) G6N34_RS07505 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein G6N34_RS07515 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) G6N34_RS07570 ENOG4105DRS transport system, permease G6N34_RS07575 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component G6N34_RS07585 ENOG4105MWK D-amino acid dehydrogenase, small subunit G6N34_RS07590 ENOG4107YD5 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) G6N34_RS07615 ENOG4105C5W Aldolase G6N34_RS07625 ENOG4107RID 5-oxoprolinase (ATP-hydrolyzing) G6N34_RS07630 ENOG4105C2C drug resistance transporter, Bcr CflA G6N34_RS07695 ENOG4105CHR reductase G6N34_RS07700 ENOG4105C7K acetolactate synthase G6N34_RS07710 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) G6N34_RS07720 ENOG4105JZI cytochrome P450 G6N34_RS07835 ENOG4105D5G Transposase G6N34_RS07840 ENOG4105C0D helicase G6N34_RS07845 ENOG4105C9U ATP-dependent DNA helicase RecQ G6N34_RS07850 ENOG4105CFI type iii restriction protein res subunit G6N34_RS07975 ENOG4105D8X mechanosensitive ion channel G6N34_RS07990 ENOG4107SHJ sulfite reductase subunit b G6N34_RS07995 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) G6N34_RS08010 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) G6N34_RS08015 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) G6N34_RS08100 ENOG4108MUZ hydrolase G6N34_RS08110 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) G6N34_RS08160 ENOG4107RCI amp-dependent synthetase and ligase G6N34_RS08175 ENOG4105CVN desaturase G6N34_RS08190 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) G6N34_RS08220 ENOG4105CUB amino acid G6N34_RS08245 ENOG4107WGA YidE YbjL G6N34_RS08260 ENOG4105C7N Xanthine uracil vitamin C permease G6N34_RS08270 ENOG4105F8J Adenylate Guanylate cyclase G6N34_RS08310 ENOG4108JQ6 ABC transporter G6N34_RS08315 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component G6N34_RS08325 ENOG4105DEF Extracellular solute-binding protein, family 5 G6N34_RS08340 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) G6N34_RS08345 ENOG4105CFG Acts as a chaperone (By similarity) G6N34_RS08375 ENOG4107S1E Beta-lactamase G6N34_RS08420 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) G6N34_RS08430 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase G6N34_RS08440 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) G6N34_RS08470 ENOG41082SX arsR family transcriptional regulator G6N34_RS08525 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) G6N34_RS08565 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) G6N34_RS08570 ENOG4105EEM helicase G6N34_RS08615 ENOG4108RZE Tetr family transcriptional regulator G6N34_RS08620 ENOG4108UKI Enoyl-CoA hydratase G6N34_RS08650 ENOG4105C5F glutamine synthetase G6N34_RS08655 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) G6N34_RS08675 ENOG4105MGM doxx family G6N34_RS08680 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) G6N34_RS08685 ENOG4105C5F glutamine synthetase G6N34_RS08705 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) G6N34_RS08710 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) G6N34_RS08735 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) G6N34_RS08745 ENOG4105CM2 brancheD-chain amino acid aminotransferase G6N34_RS08755 ENOG410813T Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) G6N34_RS08765 ENOG4108YZT Adenosylcobinamide kinase G6N34_RS08790 ENOG4107T4Z adenosine kinase G6N34_RS08805 ENOG4108ZRS Part of cytochrome c oxidase, its function is G6N34_RS08830 ENOG4107UDY cytochrome C G6N34_RS08835 ENOG4105CCU oxidase (Subunit III) G6N34_RS08840 ENOG4108I0Q anthranilate phosphoribosyltransferase G6N34_RS08885 ENOG4105D0U Arsenite-activated ATPase (ArsA) G6N34_RS08900 ENOG4108VJY integral membrane protein G6N34_RS08915 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase G6N34_RS08925 ENOG4105KYH transcriptional regulatory protein G6N34_RS08930 ENOG41090CE integral membrane protein G6N34_RS08940 ENOG4105R14 (LipO)protein G6N34_RS08970 ENOG4105CJN penicillin-binding protein G6N34_RS08985 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) G6N34_RS09000 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) G6N34_RS09060 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) G6N34_RS09085 ENOG4105JN3 extra-cytoplasmic solute receptor family protein G6N34_RS09100 ENOG4105SHT UspA domain-containing protein G6N34_RS09110 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit G6N34_RS09115 ENOG4108IFG nitrite reductase, (NAD(P)H) G6N34_RS09125 ENOG4107QND Nitrite extrusion protein G6N34_RS09130 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) G6N34_RS09135 ENOG4105C01 Dihydroxy-acid dehydratase G6N34_RS09165 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) G6N34_RS09185 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) G6N34_RS09205 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) G6N34_RS09230 ENOG4108RM3 Phosphatase with a broad specificity. Its primary physiological function is to dephosphorylate 3'-phosphoadenosine 5'-phosphate (PAP) and 3'-phosphoadenosine 5'-phosphosulfate (PAPS). Thus, plays a role in mycobacterial sulfur metabolism, since it can serve as a key regulator of the sulfate assimilation pathway by controlling the pools of PAP and PAPS in the cell. To a lesser extent, is also able to hydrolyze inositol 1-phosphate (I- 1-P), fructose 1,6-bisphosphate (FBP) (to fructose 6-phosphate (F- 6-P)) and AMP in vitro, but this might has no significance in vivo G6N34_RS09255 ENOG4105C3R Methionine synthase G6N34_RS09280 ENOG4108IJ9 (ABC) transporter G6N34_RS09285 ENOG4107T8P acyl-Coa dehydrogenase G6N34_RS09300 ENOG4105M0N phosphoribosyl-ATP pyrophosphatase G6N34_RS09305 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) G6N34_RS09315 ENOG4107QN2 dihydrolipoyl dehydrogenase G6N34_RS09320 ENOG4105CS1 NAD(P)H quinone oxidoreductase G6N34_RS09365 ENOG4105DHM ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity) G6N34_RS09390 ENOG4105CI2 imidazolone-5-propionate hydrolase G6N34_RS09395 ENOG4105E5F proteasome G6N34_RS09405 ENOG4105KPK Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) G6N34_RS09410 ENOG4105F7N Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) G6N34_RS09425 ENOG4105E33 succinate dehydrogenase G6N34_RS09430 ENOG4107QPK )-transporter G6N34_RS09465 ENOG4105C32 Amino acid ABC transporter (Permease) G6N34_RS09470 ENOG4105CF8 branched-chain amino acid ABC transporter, permease G6N34_RS09475 ENOG4105C0Z ABC transporter G6N34_RS09480 ENOG4108IV0 ABC, transporter G6N34_RS09485 ENOG41063C6 UPF0235 protein G6N34_RS09495 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) G6N34_RS09515 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) G6N34_RS09560 ENOG41082T9 Membrane G6N34_RS09580 ENOG4105C5X domain protein G6N34_RS09615 ENOG4105CRK lysyL-tRNA synthetase G6N34_RS09645 ENOG4105C1G acyl-Coa dehydrogenase G6N34_RS09660 ENOG4105CBC glutamate synthase G6N34_RS09665 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) G6N34_RS09670 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) G6N34_RS09680 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) G6N34_RS09685 ENOG4105CAS nag kinase G6N34_RS09690 ENOG4105C8Y Acetylornithine aminotransferase G6N34_RS09695 ENOG4105DBV ornithine carbamoyltransferase G6N34_RS09705 ENOG4105CDH Citrulline--aspartate ligase G6N34_RS09710 ENOG4105CH7 arginosuccinase G6N34_RS09725 ENOG4105C5H ABC transporter G6N34_RS09740 ENOG4105W49 UPF0434 protein G6N34_RS09745 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) G6N34_RS09755 ENOG4105CJ1 ABC, transporter G6N34_RS09790 ENOG4105DSU hydrolase G6N34_RS09825 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) G6N34_RS09840 ENOG4105CIH Imidazole acetol-phosphate transaminase G6N34_RS09855 ENOG4105C7K acetolactate synthase G6N34_RS09865 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) G6N34_RS09870 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) G6N34_RS09885 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) G6N34_RS09895 ENOG410635A Membrane G6N34_RS09925 ENOG41061TZ Short-chain dehydrogenase reductase Sdr G6N34_RS09955 ENOG4107YCR Transcriptional regulator, ARSR family G6N34_RS09970 ENOG4108UXE Protein tyrosine phosphatase G6N34_RS10050 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic G6N34_RS10070 ENOG4107QUV Domain protein G6N34_RS10220 ENOG4105CV8 reductase G6N34_RS10230 ENOG4105CHR reductase G6N34_RS10255 ENOG410814C multidrug resistance protein G6N34_RS10260 ENOG410814C multidrug resistance protein G6N34_RS10265 ENOG4105EBR Carboxylesterase G6N34_RS10280 ENOG4105CKD glutathione-regulated potassium-efflux system protein G6N34_RS10285 ENOG4105CJP fad dependent oxidoreductase G6N34_RS10315 ENOG4107EFR Flavocytochrome c G6N34_RS10325 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving G6N34_RS10350 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) G6N34_RS10355 ENOG4108UW8 fha domain-containing protein G6N34_RS10395 ENOG4107UAX integral membrane protein G6N34_RS10400 ENOG4105C37 (CBS) domain G6N34_RS10405 ENOG4107QKW extracellular solute-binding protein family 1 G6N34_RS10415 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) G6N34_RS10425 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) G6N34_RS10450 ENOG4108YZ9 Urea amidohydrolase subunit gamma G6N34_RS10460 ENOG4105CQM Urea amidohydrolase subunit alpha G6N34_RS10470 ENOG4107S16 Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) G6N34_RS10475 ENOG4105MT3 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) G6N34_RS10480 ENOG4105CEP NADH dehydrogenase G6N34_RS10485 ENOG4105DYW oxidoreductase G6N34_RS10520 ENOG4107QRI Phosphoketolase G6N34_RS10535 ENOG4105CHU acetyl-coa acetyltransferase G6N34_RS10570 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) G6N34_RS10575 ENOG4105D64 Mechanosensitive ion channel G6N34_RS10580 ENOG4105BZU Histidine kinase G6N34_RS10620 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) G6N34_RS10630 ENOG4105DRR Transcriptional regulator, GntR family G6N34_RS10655 ENOG4108UKI Enoyl-CoA hydratase G6N34_RS10665 ENOG4108UQY Iron-storage protein G6N34_RS10680 ENOG4105C5F glutamine synthetase G6N34_RS10690 ENOG4105CYC Transferase G6N34_RS10705 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) G6N34_RS10715 ENOG4105C29 acyl-CoA thioesterase G6N34_RS10745 ENOG4105QPS Monooxygenase G6N34_RS10825 ENOG4105CIR epoxide hydrolase G6N34_RS10835 ENOG4105CEV competence damage-inducible protein G6N34_RS10865 ENOG4107XFJ UPF0246 protein G6N34_RS10885 ENOG4105PP6 Membrane G6N34_RS10900 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) G6N34_RS10910 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) G6N34_RS10915 ENOG4107TCW O-succinylbenzoate synthase G6N34_RS10935 ENOG4105ETU transcriptional activator (TenA G6N34_RS10940 ENOG4105CEY Amp-dependent synthetase and ligase G6N34_RS10955 ENOG4107SCK Monooxygenase G6N34_RS10980 ENOG4105CEP NADH dehydrogenase G6N34_RS11005 ENOG4105CPQ Dehydrogenase G6N34_RS11015 ENOG4105E1F short-chain dehydrogenase reductase G6N34_RS11020 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit G6N34_RS11045 ENOG4105ECQ AraC Family Transcriptional Regulator G6N34_RS11065 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) G6N34_RS11090 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes G6N34_RS11105 ENOG4108V1T peptidylprolyl cis-trans isomerase G6N34_RS11125 ENOG4105EWK phytoene G6N34_RS11140 ENOG4105E39 Enoyl-CoA hydratase G6N34_RS11160 ENOG4108SVW integral membrane protein G6N34_RS11170 ENOG4105MHT Transcriptional regulator, ARSR family G6N34_RS11225 ENOG4105CHR reductase G6N34_RS11235 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) G6N34_RS11240 ENOG4105DYW oxidoreductase G6N34_RS11290 ENOG4105CHR reductase G6N34_RS11310 ENOG4105CPQ Dehydrogenase G6N34_RS11335 ENOG4105D29 Helix-turn-helix type 11 domain protein G6N34_RS11345 ENOG4108VWS Yaeq family G6N34_RS11350 ENOG4105EMU Dehydrogenase G6N34_RS11355 ENOG4108Q5F Tetr family transcriptional regulator G6N34_RS11370 ENOG4108JEB The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) G6N34_RS11380 ENOG4105DIK (ABC) transporter G6N34_RS11420 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component G6N34_RS11425 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component G6N34_RS11430 ENOG4105MXW flavin reductase domain protein, FMN-binding G6N34_RS11445 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) G6N34_RS11450 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein G6N34_RS11470 ENOG4105CTX dehydratase G6N34_RS11510 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) G6N34_RS11525 ENOG4105C8P )-transporter G6N34_RS11535 ENOG4105CFN oxalyl-CoA decarboxylase G6N34_RS11555 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b G6N34_RS11570 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) G6N34_RS11580 ENOG4108RQS Two component transcriptional regulator (Winged helix family G6N34_RS11585 ENOG4105BZU Histidine kinase G6N34_RS11595 ENOG4105FBW Monooxygenase G6N34_RS11605 ENOG4105C1G acyl-Coa dehydrogenase G6N34_RS11625 ENOG4107YD3 Thioesterase G6N34_RS11630 ENOG4108JQ1 Dehydrogenase G6N34_RS11665 ENOG4107AQZ Membrane G6N34_RS11675 ENOG4105CHR reductase G6N34_RS11680 ENOG4108JGH Tetr family transcriptional regulator G6N34_RS11690 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) G6N34_RS11700 ENOG4105F38 ABC transporter, permease G6N34_RS11705 ENOG4105D38 putrescine abc transporter G6N34_RS11720 ENOG4108RWI nicotinamidase G6N34_RS11730 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) G6N34_RS11735 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) G6N34_RS11765 ENOG4105C6Z Gluconate G6N34_RS11770 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family G6N34_RS11795 ENOG4105EBR Carboxylesterase G6N34_RS11810 ENOG4105Q70 G6N34_RS11815 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) G6N34_RS11825 ENOG4105CPN adenine deaminase G6N34_RS11845 ENOG4105CTK cobaltochelatase, cobn subunit G6N34_RS11885 ENOG4108RG3 short-chain dehydrogenase reductase G6N34_RS11970 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction G6N34_RS11975 ENOG4107GJV short-chain dehydrogenase reductase G6N34_RS11990 ENOG4105WH1 Two component transcriptional regulator luxr family G6N34_RS12005 ENOG4105CDA abc transporter atp-binding protein G6N34_RS12015 ENOG4106PMH Extracellular solute-binding protein family 3 G6N34_RS12025 ENOG4105C4M (Ubiquinol oxidase) subunit I G6N34_RS12030 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii G6N34_RS12035 ENOG4108JJ9 ABC, transporter G6N34_RS12050 ENOG4105C29 acyl-CoA thioesterase G6N34_RS12065 ENOG4105CBC glutamate synthase G6N34_RS12085 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) G6N34_RS12095 ENOG4105DK0 Indole-3-glycerol phosphate synthase G6N34_RS12105 ENOG4105CRQ synthase (Component I) G6N34_RS12115 ENOG4105E2A Dehydrogenase G6N34_RS12120 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase G6N34_RS12130 ENOG4108MWI inositol mono-phosphatase G6N34_RS12140 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) G6N34_RS12145 ENOG4105ECC imidazole-glycerol-phosphate dehydratase G6N34_RS12150 ENOG4105CIH Imidazole acetol-phosphate transaminase G6N34_RS12155 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) G6N34_RS12160 ENOG410829K Lysine exporter protein (Lyse ygga) G6N34_RS12190 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) G6N34_RS12215 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) G6N34_RS12220 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) G6N34_RS12230 ENOG4107WHG Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) G6N34_RS12235 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) G6N34_RS12300 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) G6N34_RS12320 ENOG4107ZIW This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) G6N34_RS12325 ENOG4105HDK L-asparaginase G6N34_RS12335 ENOG410848D S4 domain protein YaaA G6N34_RS12340 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) G6N34_RS12380 ENOG4107S1E Beta-lactamase G6N34_RS12455 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH G6N34_RS12460 ENOG4105CHR reductase G6N34_RS12465 ENOG4107QVM von Willebrand factor, type A G6N34_RS12475 ENOG4105C7R Atpase associated with various cellular activities aaa_3 G6N34_RS12485 ENOG4105ZXU NLP P60 protein G6N34_RS12495 ENOG4107QM5 aconitate hydratase G6N34_RS12500 ENOG4108Q5F Tetr family transcriptional regulator G6N34_RS12510 ENOG4105C5H ABC transporter G6N34_RS12520 ENOG41080RH Thioredoxin G6N34_RS12525 ENOG4105VG1 fes assembly suf system protein G6N34_RS12530 ENOG4108UNV SUF system FeS assembly protein, NifU family G6N34_RS12540 ENOG4105C3K feS assembly ATPase SufC G6N34_RS12560 ENOG4107JC6 Membrane G6N34_RS12585 ENOG4105DND Transcriptional regulator G6N34_RS12595 ENOG4108IJ0 Aspartate ammonia-lyase G6N34_RS12620 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein G6N34_RS12635 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) G6N34_RS12655 ENOG41080R8 Conserved Protein G6N34_RS12665 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) G6N34_RS12690 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) G6N34_RS12700 ENOG4105CP7 Triose-phosphate isomerase G6N34_RS12705 ENOG4105BZA Phosphoglycerate kinase G6N34_RS12710 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase G6N34_RS12735 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) G6N34_RS12750 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) G6N34_RS12765 ENOG4107UWP Major facilitator superfamily MFS_1 G6N34_RS12785 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) G6N34_RS12790 ENOG4108V0P LemA family G6N34_RS12825 ENOG4105MTQ Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) G6N34_RS12845 ENOG4105SKN orotidine 5''-phosphate decarboxylase G6N34_RS12850 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain G6N34_RS12855 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain G6N34_RS12870 ENOG4105CXT aspartate transcarbamylase G6N34_RS12875 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) G6N34_RS12905 ENOG4107T8P acyl-Coa dehydrogenase G6N34_RS12910 ENOG4106NZI LysR family Transcriptional regulator G6N34_RS12930 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) G6N34_RS12935 ENOG4105DC7 peptidase M24 G6N34_RS12945 ENOG4105D49 3-dehydroquinate synthase G6N34_RS12965 ENOG4105E2X shikimate dehydrogenase G6N34_RS12975 ENOG41080G3 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) G6N34_RS12980 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) G6N34_RS12985 ENOG4107ZED Uncharacterised protein family UPF0047 G6N34_RS13040 ENOG4105CHU acetyl-coa acetyltransferase G6N34_RS13050 ENOG4107S2E monooxygenase G6N34_RS13060 ENOG4105C9M aspartyl-trna synthetase G6N34_RS13070 ENOG4105EBR Carboxylesterase G6N34_RS13090 ENOG4108RZE Tetr family transcriptional regulator G6N34_RS13100 ENOG4105D2B acyl-CoA dehydrogenase G6N34_RS13105 ENOG4105CC9 acyl-Coa dehydrogenase G6N34_RS13130 ENOG41083Z3 extracellular ligand-binding receptor G6N34_RS13135 ENOG4105C32 Amino acid ABC transporter (Permease) G6N34_RS13145 ENOG4105C0Z ABC transporter G6N34_RS13150 ENOG4108IV0 ABC, transporter G6N34_RS13160 ENOG4105CUT histidyl-tRNA synthetase G6N34_RS13175 ENOG4108ZR3 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity) G6N34_RS13180 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) G6N34_RS13185 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) G6N34_RS13190 ENOG4108NY6 Extracellular solute-binding protein, family 5 G6N34_RS13195 ENOG4107RTU Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) G6N34_RS13215 ENOG4108IQE Amp-dependent synthetase and ligase G6N34_RS13225 ENOG4105E4E Thioester reductase domain-containing protein G6N34_RS13345 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) G6N34_RS13365 ENOG4107SCA Formamidase (EC 3.5.1.49) G6N34_RS13400 ENOG4105CDY transcriptional regulatory protein G6N34_RS13405 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) G6N34_RS13410 ENOG4105C29 acyl-CoA thioesterase G6N34_RS13415 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) G6N34_RS13420 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) G6N34_RS13425 ENOG4105E2K Glycosyl transferase (Group 1 G6N34_RS13430 ENOG4107YQ3 lipid a biosynthesis lauroyl acyltransferase G6N34_RS13445 ENOG4105C22 threonyL-tRNA synthetase G6N34_RS13475 ENOG41080W3 amp-dependent synthetase and ligase G6N34_RS13500 ENOG4105CHR reductase G6N34_RS13505 ENOG4105C26 Dehydrogenase G6N34_RS13650 ENOG4108P2G integral membrane protein G6N34_RS13655 ENOG4105E0X reductase G6N34_RS13660 ENOG4107JTW chlorite dismutase G6N34_RS13670 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) G6N34_RS13700 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) G6N34_RS13710 ENOG4105C0X amino acid G6N34_RS13715 ENOG4107VEG TrkA-N domain protein G6N34_RS13745 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) G6N34_RS13865 ENOG4105C1G acyl-Coa dehydrogenase G6N34_RS13870 ENOG4108J2R molybdopterin oxidoreductase G6N34_RS13875 ENOG4108SGK Tetr family transcriptional regulator G6N34_RS13880 ENOG4105D2B acyl-CoA dehydrogenase G6N34_RS13900 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) G6N34_RS13905 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) G6N34_RS13910 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) G6N34_RS13920 ENOG4105PP6 Membrane G6N34_RS13925 ENOG4105C99 atpase involved in dna repair G6N34_RS13935 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) G6N34_RS13940 ENOG4105CDA abc transporter atp-binding protein G6N34_RS13945 ENOG4107UBR Extracellular solute-binding protein family 3 G6N34_RS13950 ENOG4108Q1T ABC transporter G6N34_RS13955 ENOG4105DRP amino acid AbC transporter G6N34_RS13960 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone G6N34_RS13965 ENOG4105KC9 Modulates RecA activity (By similarity) G6N34_RS13970 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) G6N34_RS13990 ENOG4105MXB limonene-12-epoxide hydrolase G6N34_RS14010 ENOG4105WBV Transcriptional regulator G6N34_RS14030 ENOG41067V3 Antibiotic biosynthesis monooxygenase G6N34_RS14050 ENOG4105CN5 Metallo-Beta-Lactamase G6N34_RS14055 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) G6N34_RS14060 ENOG4107SMJ Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) G6N34_RS14080 ENOG4108J2P Alpha beta hydrolase fold G6N34_RS14085 ENOG4105T0Z Conserved Protein G6N34_RS14105 ENOG4105CI0 Citrate lyase G6N34_RS14140 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) G6N34_RS14155 ENOG4105DCF alanine dehydrogenase G6N34_RS14180 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) G6N34_RS14190 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) G6N34_RS14245 ENOG4105E39 Enoyl-CoA hydratase G6N34_RS14260 ENOG4105SFS phosphoesterase RecJ domain protein G6N34_RS14270 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) G6N34_RS14285 ENOG4107Z1I Required for maturation of 30S ribosomal subunits (By similarity) G6N34_RS14310 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) G6N34_RS14335 ENOG4105DWT malate dehydrogenase (quinone) G6N34_RS14350 ENOG4108JJB ABC transporter G6N34_RS14365 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) G6N34_RS14375 ENOG41073TP transcriptional regulator G6N34_RS14380 ENOG41061TZ Short-chain dehydrogenase reductase Sdr G6N34_RS14390 ENOG4108Z86 Glutamine amidotransferase G6N34_RS14400 ENOG4108IQI permease G6N34_RS14405 ENOG4105CAQ asparagine synthetase G6N34_RS14450 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) G6N34_RS14460 ENOG4105DZP Membrane-associated zinc metalloprotease G6N34_RS14465 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) G6N34_RS14485 ENOG4105CHR reductase G6N34_RS14505 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs G6N34_RS14525 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) G6N34_RS14530 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) G6N34_RS14535 ENOG4105CHR reductase G6N34_RS14555 ENOG4105DV0 amidase (EC 3.5.1.4 G6N34_RS14560 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone G6N34_RS14565 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) G6N34_RS14570 ENOG4105CE9 30S ribosomal protein S2 G6N34_RS14585 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) G6N34_RS14620 ENOG4105MHT Transcriptional regulator, ARSR family G6N34_RS14645 ENOG41080R2 UPF0102 protein G6N34_RS14665 ENOG4107QYR Signal peptidase i G6N34_RS14695 ENOG4105K5M 30s ribosomal protein S16 G6N34_RS14705 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) G6N34_RS14710 ENOG4105DZ1 carboxypeptidase G6N34_RS14715 ENOG4105DZ1 carboxypeptidase G6N34_RS14730 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) G6N34_RS14755 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) G6N34_RS14770 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) G6N34_RS14810 ENOG4106H78 methyltransferase G6N34_RS14815 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) G6N34_RS14820 ENOG4108M9J MaoC like domain protein G6N34_RS14825 ENOG4105C1G acyl-Coa dehydrogenase G6N34_RS14845 ENOG4105CV8 reductase G6N34_RS14855 ENOG4105CB5 ATP-dependent DNA helicase recG G6N34_RS14860 ENOG4105DP4 dak2 domain fusion protein ylov G6N34_RS14875 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) G6N34_RS14900 ENOG4105C28 cystathionine G6N34_RS14915 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) G6N34_RS14930 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) G6N34_RS14935 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) G6N34_RS14965 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) G6N34_RS14970 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase G6N34_RS14985 ENOG4105E5T Major Facilitator Superfamily G6N34_RS14995 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) G6N34_RS15000 ENOG4108JQ1 Dehydrogenase G6N34_RS15015 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase G6N34_RS15020 ENOG4108ZP8 Acetolactate synthase small subunit G6N34_RS15050 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) G6N34_RS15060 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) G6N34_RS15065 ENOG41081AP Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) G6N34_RS15090 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) G6N34_RS15100 ENOG4105NPE arsR family transcriptional regulator G6N34_RS15125 ENOG4105CTS PTS system mannitol-specific G6N34_RS15130 ENOG4105CPQ Dehydrogenase G6N34_RS15135 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) G6N34_RS15155 ENOG4105C10 Electron transfer flavoprotein G6N34_RS15165 ENOG4108KQJ Type 11 methyltransferase G6N34_RS15180 ENOG4105EVB acetyltransferase G6N34_RS15185 ENOG4108V0V Pyrrolo-quinoline quinone G6N34_RS15220 ENOG4105DKW ABC transporter G6N34_RS15225 ENOG4108VW9 Membrane G6N34_RS15230 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family G6N34_RS15255 ENOG4105DQ4 alcohol dehydrogenase G6N34_RS15275 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) G6N34_RS15305 ENOG4105F95 Monooxygenase G6N34_RS15320 ENOG4105EJ2 Transcriptional regulator G6N34_RS15345 ENOG41089UC methyltransferase, type 11 G6N34_RS15355 ENOG4105CJ1 ABC, transporter G6N34_RS15430 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) G6N34_RS15435 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) G6N34_RS15445 ENOG4108YYH Nadph-dependent fmn reductase G6N34_RS15500 ENOG4105CHH sulfate transporter G6N34_RS15515 ENOG4105CQS hydrogenase expression formation protein HypD G6N34_RS15530 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) G6N34_RS15545 ENOG4105DPX Hydrogenase, large subunit G6N34_RS15575 ENOG4105WRB Hydrogenase assembly chaperone hypC hupF G6N34_RS15590 ENOG4108QIU Dehydrogenase G6N34_RS15615 ENOG4105C7K acetolactate synthase G6N34_RS15620 ENOG4107YCY Transcriptional regulator G6N34_RS15625 ENOG4105D2B acyl-CoA dehydrogenase G6N34_RS15645 ENOG4105D22 carbon starvation protein G6N34_RS15660 ENOG4105F27 Major Facilitator G6N34_RS15670 ENOG4105D5U fad dependent oxidoreductase G6N34_RS15675 ENOG4105CC9 acyl-Coa dehydrogenase G6N34_RS15680 ENOG4105C1G acyl-Coa dehydrogenase G6N34_RS15695 ENOG4105H9W Short-chain dehydrogenase reductase Sdr G6N34_RS15710 ENOG410900P UPF0336 protein G6N34_RS15715 ENOG410900P UPF0336 protein G6N34_RS15730 ENOG41061TZ Short-chain dehydrogenase reductase Sdr G6N34_RS15800 ENOG4105DYW oxidoreductase G6N34_RS15810 ENOG4105CEY Amp-dependent synthetase and ligase G6N34_RS15820 ENOG4105GCF PGAM G6N34_RS15835 ENOG4105CSU acyl-Coa dehydrogenase G6N34_RS15855 ENOG4105CHR reductase G6N34_RS15875 ENOG4105E39 Enoyl-CoA hydratase G6N34_RS15880 ENOG4105CHR reductase G6N34_RS15895 ENOG4105CJW magnesium transporter G6N34_RS15900 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) G6N34_RS15915 ENOG4105C2W permease G6N34_RS15930 ENOG41061H0 Monooxygenase G6N34_RS15935 ENOG4107QUY Guanine deaminase G6N34_RS15945 ENOG4105C7W Xanthine dehydrogenase G6N34_RS15955 ENOG4107GJV short-chain dehydrogenase reductase G6N34_RS15965 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) G6N34_RS16030 ENOG4108KPJ rna polymerase sigma factor G6N34_RS16045 ENOG4105EMN RNA polymerase sigma factor G6N34_RS16065 ENOG4108RJ7 Catalyzes the hydrolysis of nucleoside triphosphates, with a preference for pyrimidine deoxynucleoside triphosphates (dUTP, dTTP and dCTP) (By similarity) G6N34_RS16075 ENOG4107RGD Major Facilitator superfamily G6N34_RS16210 ENOG4105DQE DNA ligase G6N34_RS16225 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) G6N34_RS16235 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) G6N34_RS16240 ENOG4107RYD Part of the ABC transporter FtsEX involved in cellular division (By similarity) G6N34_RS16245 ENOG4105CAK Cell division ATP-binding protein ftsE G6N34_RS16255 ENOG4105D8X mechanosensitive ion channel G6N34_RS16260 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) G6N34_RS16270 ENOG4105K6B K06886 hemoglobin G6N34_RS16280 ENOG4107TK4 histidinol-phosphate phosphatase G6N34_RS16290 ENOG4105C1G acyl-Coa dehydrogenase G6N34_RS16295 ENOG4107S5I aldo keto reductase G6N34_RS16325 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G6N34_RS16330 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase G6N34_RS16365 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) G6N34_RS16370 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain G6N34_RS16390 ENOG4108IEH NADH dehydrogenase subunit g G6N34_RS16395 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) G6N34_RS16400 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) G6N34_RS16405 ENOG4105DF2 NADH dehydrogenase subunit j G6N34_RS16410 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) G6N34_RS16425 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) G6N34_RS16445 ENOG4105CHR reductase G6N34_RS16545 ENOG4105GMT ATPase associated with various cellular activities aaa_5 G6N34_RS16565 ENOG4108UKI Enoyl-CoA hydratase G6N34_RS16585 ENOG4108JPW Aminotransferase G6N34_RS16590 ENOG4105C1G acyl-Coa dehydrogenase G6N34_RS16595 ENOG4105C26 Dehydrogenase G6N34_RS16600 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G6N34_RS16610 ENOG4108Z86 Glutamine amidotransferase G6N34_RS16615 ENOG4108Z86 Glutamine amidotransferase G6N34_RS16675 ENOG4105EXC Acyl-transferase G6N34_RS16690 ENOG4105CEY Amp-dependent synthetase and ligase G6N34_RS16700 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) G6N34_RS16735 ENOG41080RH Thioredoxin G6N34_RS16745 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) G6N34_RS16775 ENOG4105CK7 Sodium proline symporter G6N34_RS16795 ENOG4105DJZ UPF0182 protein G6N34_RS16800 ENOG41063PX domain protein G6N34_RS16815 ENOG4105FAE von Willebrand factor, type A G6N34_RS16820 ENOG4105GMT ATPase associated with various cellular activities aaa_5 G6N34_RS16830 ENOG4108IG5 Transcriptional regulator G6N34_RS16840 ENOG4105WBQ Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) G6N34_RS16865 ENOG4107SVH Potassium channel protein G6N34_RS16885 ENOG4108YIQ Alpha beta hydrolase G6N34_RS16930 ENOG4105C1J atp-dependent rna helicase G6N34_RS16945 ENOG4108ZM9 phosphoglycerate mutase G6N34_RS16965 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) G6N34_RS16975 ENOG4105CBD Diacylglycerol kinase G6N34_RS16990 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit G6N34_RS16995 ENOG4105WMN AntiSigma factor G6N34_RS17000 ENOG4105EMN RNA polymerase sigma factor G6N34_RS17005 ENOG4108Z66 YbaK ebsC protein G6N34_RS17010 ENOG4105H9W Short-chain dehydrogenase reductase Sdr G6N34_RS17015 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) G6N34_RS17030 ENOG4108RAV Conserved protein G6N34_RS17035 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase G6N34_RS17040 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) G6N34_RS17060 ENOG4105CSR polyphosphate kinase 2 G6N34_RS17080 ENOG4108S7Q sigma 54 modulation protein ribosomal protein S30ea G6N34_RS17090 ENOG4105G3P Lipoprotein lpqB G6N34_RS17095 ENOG4105BZU Histidine kinase G6N34_RS17100 ENOG4105CK6 Two component transcriptional regulator (Winged helix family G6N34_RS17140 ENOG4105VCQ rubredoxin G6N34_RS17145 ENOG41084UD rubredoxin G6N34_RS17150 ENOG4105EEF Alkane 1-monooxygenase G6N34_RS17155 ENOG4105CUB amino acid G6N34_RS17165 ENOG4105EIP mannose-6-phosphate isomerase G6N34_RS17175 ENOG4107QKV phosphomannomutase G6N34_RS17190 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) G6N34_RS17200 ENOG41088YA Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives (By similarity) G6N34_RS17225 ENOG4107TB5 TRANSCRIPTIONal G6N34_RS17235 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase G6N34_RS17270 ENOG4108Z90 colanic acid biosynthesis acetyltransferase wcaF G6N34_RS17275 ENOG4107T8Q Glycosyl transferase (Group 1 G6N34_RS17315 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family G6N34_RS17325 ENOG4105C30 Nad-dependent epimerase dehydratase G6N34_RS17340 ENOG4105C0K Gdp-mannose 4,6-dehydratase G6N34_RS17345 ENOG4106CD9 glycosyl transferase group 1 G6N34_RS17355 ENOG4105CAQ asparagine synthetase G6N34_RS17365 ENOG410829W Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) G6N34_RS17390 ENOG4105EQK -acetyltransferase G6N34_RS17405 ENOG4107QPT Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) G6N34_RS17420 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) G6N34_RS17425 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit G6N34_RS17445 ENOG4107ZF2 Phosphatase G6N34_RS17490 ENOG4105C6Y Udp-glucose 6-dehydrogenase G6N34_RS17510 ENOG4105D8K carboxyl transferase G6N34_RS17540 ENOG4108JIK carboxylase G6N34_RS17555 ENOG4105D9Z Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) G6N34_RS17605 ENOG4105C26 Dehydrogenase G6N34_RS17640 ENOG41061ZR Transcriptional regulator G6N34_RS17645 ENOG4107QRT dEAD DEAH box helicase G6N34_RS17710 ENOG4105EJ2 Transcriptional regulator G6N34_RS17735 ENOG4107RM1 amidohydrolase G6N34_RS17750 ENOG4108KK1 membrane protein AbrB duplication G6N34_RS17755 ENOG4108VHT MarR family transcriptional regulator G6N34_RS17760 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain G6N34_RS17780 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) G6N34_RS17810 ENOG4105E33 succinate dehydrogenase G6N34_RS17820 ENOG4106ETB IIa component G6N34_RS17825 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC G6N34_RS17830 ENOG4107ZN8 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) G6N34_RS17835 ENOG4108KPJ rna polymerase sigma factor G6N34_RS17860 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) G6N34_RS17870 ENOG4105DZ1 carboxypeptidase G6N34_RS17880 ENOG4107H3J ribonuclease G6N34_RS17905 ENOG4108IQK o-acetylhomoserine G6N34_RS17935 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase G6N34_RS17940 ENOG4105IDI abc transporter atp-binding protein G6N34_RS17950 ENOG4107Z6C Pentapeptide repeat-containing protein G6N34_RS17965 ENOG4105GWZ Roadblock lc7 family protein G6N34_RS17970 ENOG4105BZU Histidine kinase G6N34_RS17975 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) G6N34_RS17990 ENOG4105C0B DNA polymerase III (alpha subunit) G6N34_RS18010 ENOG4105D5Q Arginine ornithine antiporter G6N34_RS18025 ENOG4105C29 acyl-CoA thioesterase G6N34_RS18030 ENOG4105GCF PGAM G6N34_RS18050 ENOG4105DU0 nucleoside hydrolase G6N34_RS18065 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) G6N34_RS18080 ENOG4107QVP Dehydrogenase G6N34_RS18090 ENOG4108VT4 G6N34_RS18110 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) G6N34_RS18120 ENOG4108ESY Metal dependent phosphohydrolase G6N34_RS18140 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) G6N34_RS18155 ENOG4105F8J Adenylate Guanylate cyclase G6N34_RS18190 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) G6N34_RS18195 ENOG41080E2 ribosomal-protein-alanine acetyltransferase G6N34_RS18220 ENOG4105CVK Glutamate decarboxylase G6N34_RS18235 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) G6N34_RS18270 ENOG4105D2B acyl-CoA dehydrogenase G6N34_RS18275 ENOG4105D2B acyl-CoA dehydrogenase G6N34_RS18280 ENOG4105CEY Amp-dependent synthetase and ligase G6N34_RS18285 ENOG4105CPP Dehydrogenase, E1 component G6N34_RS18290 ENOG4107RUY (E1 component), alpha subunit G6N34_RS18330 ENOG4108HWW ABC transporter G6N34_RS18335 ENOG4105C2J ABC transporter G6N34_RS18340 ENOG4105DFW ABC transporter G6N34_RS18345 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator G6N34_RS18350 ENOG4105C2J ABC transporter G6N34_RS18355 ENOG4107R9N ABC transporter G6N34_RS18360 ENOG41062B0 ABC transporter, permease G6N34_RS18365 ENOG4105ETE Transcriptional regulator (LacI family G6N34_RS18370 ENOG4105EF1 ribulokinase G6N34_RS18375 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase G6N34_RS18380 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) G6N34_RS18405 ENOG4105CHR reductase G6N34_RS18410 ENOG4106A3M Cytochrome p-450 G6N34_RS18415 ENOG4105CY3 ABC transporter, permease G6N34_RS18470 ENOG4105DYW oxidoreductase G6N34_RS18490 ENOG4108UJD 30S ribosomal protein S9 G6N34_RS18495 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) G6N34_RS18500 ENOG4105C26 Dehydrogenase G6N34_RS18515 ENOG4107RR1 TRANSCRIPTIONal G6N34_RS18535 ENOG4105EC2 ftsk spoIIIe G6N34_RS18545 ENOG41090GG peptidase S8 and S53, subtilisin, kexin, sedolisin G6N34_RS18555 ENOG4105EAH synthase G6N34_RS18595 ENOG4105NI3 Protein of unknown function (DUF3237) G6N34_RS18630 ENOG4108ZT0 50S ribosomal protein l17 G6N34_RS18645 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) G6N34_RS18650 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits G6N34_RS18675 ENOG4105C3M thioredoxin reductase G6N34_RS18715 ENOG4105C26 Dehydrogenase G6N34_RS18720 ENOG4105C1G acyl-Coa dehydrogenase G6N34_RS18755 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) G6N34_RS18765 ENOG4108XZR Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) G6N34_RS18770 ENOG4106N8J Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) G6N34_RS18780 ENOG4108XW1 Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) G6N34_RS18800 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) G6N34_RS18805 ENOG410849U 50S ribosomal protein L30 G6N34_RS18810 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) G6N34_RS18815 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) G6N34_RS18820 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) G6N34_RS18830 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) G6N34_RS18835 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits G6N34_RS18840 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) G6N34_RS18845 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) G6N34_RS18850 ENOG4105E6M Sulphatase-modifying factor protein G6N34_RS18860 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) G6N34_RS18885 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal G6N34_RS18895 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) G6N34_RS18905 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) G6N34_RS18910 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) G6N34_RS18915 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity G6N34_RS18920 ENOG4105KZR One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) G6N34_RS18925 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) G6N34_RS18930 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) G6N34_RS18945 ENOG4105EBR Carboxylesterase G6N34_RS18970 ENOG4105C57 major facilitator superfamily G6N34_RS18975 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) G6N34_RS19000 ENOG4105XDV G6N34_RS19035 ENOG4105F7P transcriptional regulator AsnC family G6N34_RS19040 ENOG4105CIK Amidinotransferase G6N34_RS19045 ENOG4105C8Y Acetylornithine aminotransferase G6N34_RS19050 ENOG4105CUB amino acid G6N34_RS19065 ENOG4105CEU Arginine dihydrolase G6N34_RS19070 ENOG4105D5Q Arginine ornithine antiporter G6N34_RS19085 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) G6N34_RS19090 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) G6N34_RS19135 ENOG4105CSU acyl-Coa dehydrogenase G6N34_RS19145 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) G6N34_RS19150 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) G6N34_RS19175 ENOG41082SK Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) G6N34_RS19180 ENOG4108VZM 50s ribosomal protein L10 G6N34_RS19185 ENOG4105DKQ ROK family G6N34_RS19205 ENOG4105CH2 amidohydrolase G6N34_RS19250 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) G6N34_RS19255 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) G6N34_RS19280 ENOG4108F01 MaoC domain protein G6N34_RS19305 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) G6N34_RS19310 ENOG41081JD Transcriptional regulator G6N34_RS19315 ENOG4108151 Beta-lactamase domain protein G6N34_RS19335 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) G6N34_RS19340 ENOG4105EUB pirin domain protein G6N34_RS19395 ENOG4108A65 Transcriptional regulator G6N34_RS19420 ENOG4105PDP Short chain dehydrogenase G6N34_RS19430 ENOG4108VPT UPF0234 protein G6N34_RS19460 ENOG4105CY3 ABC transporter, permease G6N34_RS19505 ENOG4105D0M Protease HtpX homolog G6N34_RS19515 ENOG4105P52 geranylgeranyl reductase G6N34_RS19540 ENOG4105CD3 dihydroorotase G6N34_RS19550 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) G6N34_RS19575 ENOG4108KEZ Dehydrogenase G6N34_RS19595 ENOG4105CY3 ABC transporter, permease G6N34_RS19650 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) G6N34_RS19655 ENOG4105EMU Dehydrogenase G6N34_RS19700 ENOG4107TCW O-succinylbenzoate synthase G6N34_RS19710 ENOG4105CQB FAD linked oxidase domain protein G6N34_RS19720 ENOG4105CEY Amp-dependent synthetase and ligase G6N34_RS19725 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) G6N34_RS19730 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) G6N34_RS19765 ENOG4105PDP Short chain dehydrogenase G6N34_RS19815 ENOG4108UMN azlc family G6N34_RS19820 ENOG4105CK6 Two component transcriptional regulator (Winged helix family G6N34_RS19835 ENOG4107USC Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity) G6N34_RS19900 ENOG4107QIV Cytochrome c biogenesis protein G6N34_RS19910 ENOG4108RH7 phosphoglycerate mutase G6N34_RS19920 ENOG4108J2R molybdopterin oxidoreductase G6N34_RS19925 ENOG4105MXB limonene-12-epoxide hydrolase G6N34_RS19955 ENOG4105BZU Histidine kinase G6N34_RS19990 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) G6N34_RS19995 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) G6N34_RS20000 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) G6N34_RS20055 ENOG41063NU Membrane G6N34_RS20075 ENOG4105CK6 Two component transcriptional regulator (Winged helix family G6N34_RS20080 ENOG4105BZU Histidine kinase G6N34_RS20095 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) G6N34_RS20175 ENOG4105V9F hemagglutinin G6N34_RS20185 ENOG4106BRA Membrane G6N34_RS20195 ENOG4105CSR polyphosphate kinase 2 G6N34_RS20200 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase G6N34_RS20305 ENOG4105CSH Transporter G6N34_RS20325 ENOG4105D4U had-superfamily hydrolase, subfamily iia G6N34_RS20365 ENOG4105D65 subunit l G6N34_RS20370 ENOG4105MKQ Monovalent cation H antiporter subunit C G6N34_RS20375 ENOG4108JPZ Monovalent cation H antiporter subunit D G6N34_RS20385 ENOG410684G monovalent cation H antiporter subunit F G6N34_RS20400 ENOG41061ZR Transcriptional regulator G6N34_RS20430 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) G6N34_RS20435 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) G6N34_RS20460 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) G6N34_RS20500 ENOG4108IG5 Transcriptional regulator G6N34_RS20510 ENOG4105C2W permease G6N34_RS20525 ENOG4105IIU Aminopeptidase G6N34_RS20530 ENOG4105IIU Aminopeptidase G6N34_RS20555 ENOG4107Y5I Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) G6N34_RS20570 ENOG4105CT1 (ABC) transporter G6N34_RS20575 ENOG4107Q25 Serine Threonine protein kinase G6N34_RS20580 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) G6N34_RS20625 ENOG4105CHR reductase G6N34_RS20650 ENOG4105DEN Luciferase family G6N34_RS20665 ENOG4105EMU Dehydrogenase G6N34_RS20705 ENOG4105EYF MMPL domain protein G6N34_RS20725 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis G6N34_RS20735 ENOG4107XZ0 Peptidase M50 G6N34_RS20755 ENOG4105CSV Glutaminase G6N34_RS20760 ENOG4105C5F glutamine synthetase G6N34_RS20770 ENOG4107REC cytoplasmic protein G6N34_RS20775 ENOG4105ETE Transcriptional regulator (LacI family G6N34_RS20790 ENOG4107XFB conserved TRANSMEMBRANE PROTEIN G6N34_RS20805 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) G6N34_RS20845 ENOG4105JZI cytochrome P450 G6N34_RS20875 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit G6N34_RS20910 ENOG4105KNI merR family transcriptional Regulator G6N34_RS20915 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) G6N34_RS20920 ENOG4108093 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ G6N34_RS20925 ENOG4105CFG Acts as a chaperone (By similarity) G6N34_RS21055 ENOG4105DF6 Fe-S oxidoreductase G6N34_RS21060 ENOG4105CYC Transferase G6N34_RS21065 ENOG4105E39 Enoyl-CoA hydratase G6N34_RS21080 ENOG4105CHU acetyl-coa acetyltransferase G6N34_RS21095 ENOG4105CUB amino acid G6N34_RS21115 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) G6N34_RS21125 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain G6N34_RS21130 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) G6N34_RS21135 ENOG4108Z86 Glutamine amidotransferase G6N34_RS21150 ENOG4105CPQ Dehydrogenase G6N34_RS21165 ENOG4105CUB amino acid G6N34_RS21245 ENOG4105C6Y Udp-glucose 6-dehydrogenase G6N34_RS21255 ENOG4105DHP deoxycytidine triphosphate deaminase G6N34_RS21325 ENOG4107SCK Monooxygenase G6N34_RS21390 ENOG4105YVM Phosphoesterase, PA-phosphatase related G6N34_RS21400 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) G6N34_RS21420 ENOG41090GG peptidase S8 and S53, subtilisin, kexin, sedolisin G6N34_RS21460 ENOG4108T50 Protein of unknown function (DUF690) G6N34_RS21465 ENOG4106F1P AAA ATPase, central domain protein G6N34_RS21485 ENOG4107XDR Lactoylglutathione lyase G6N34_RS21505 ENOG4105D2B acyl-CoA dehydrogenase G6N34_RS21510 ENOG4105EWI Short-chain dehydrogenase reductase Sdr G6N34_RS21530 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone G6N34_RS21545 ENOG410630P Transcriptional regulator G6N34_RS21560 ENOG41061TZ Short-chain dehydrogenase reductase Sdr G6N34_RS21640 ENOG4105C1G acyl-Coa dehydrogenase G6N34_RS21655 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) G6N34_RS21660 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit G6N34_RS21665 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit G6N34_RS21670 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit G6N34_RS21675 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit G6N34_RS21680 ENOG4108UKI Enoyl-CoA hydratase G6N34_RS21685 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase G6N34_RS21690 ENOG4105E39 Enoyl-CoA hydratase G6N34_RS21700 ENOG4105DXM phenylacetic acid degradation protein G6N34_RS21755 ENOG4105CPN adenine deaminase G6N34_RS21765 ENOG4108RYR transcriptional regulator AsnC family G6N34_RS21780 ENOG4107QSN dihydrolipoamide acetyltransferase G6N34_RS21825 ENOG4107RDF Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) G6N34_RS21835 ENOG4108RFG Tetr family transcriptional regulator G6N34_RS21885 ENOG4108RZE Tetr family transcriptional regulator G6N34_RS21895 ENOG4106UW1 Major Facilitator superfamily G6N34_RS21920 ENOG4105D63 family UPF0324 G6N34_RS21940 ENOG4107R7A Allophanate hydrolase subunit 2 G6N34_RS21975 ENOG4107QZF nitrite reductase NADPH large subunit G6N34_RS21980 ENOG4105CR4 methylisocitrate lyase G6N34_RS21995 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) G6N34_RS22020 ENOG4107RCI amp-dependent synthetase and ligase G6N34_RS22045 ENOG4105CSU acyl-Coa dehydrogenase G6N34_RS22060 ENOG4105CHR reductase G6N34_RS22070 ENOG4108W9H Tetr family transcriptional regulator G6N34_RS22090 ENOG41073B4 coagulation factor 5 8 type domain-containing protein G6N34_RS22100 ENOG4105CEY Amp-dependent synthetase and ligase G6N34_RS22110 ENOG41090MF Protein of unknown function (DUF3068) G6N34_RS22120 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) G6N34_RS22125 ENOG4108M6P methyltransferase G6N34_RS22135 ENOG4105CHU acetyl-coa acetyltransferase G6N34_RS22160 ENOG4105X7H acyl-CoA dehydrogenase G6N34_RS22165 ENOG4105C1G acyl-Coa dehydrogenase G6N34_RS22170 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase G6N34_RS22175 ENOG4106YT9 Enoyl-CoA hydratase G6N34_RS22210 ENOG4105D2B acyl-CoA dehydrogenase G6N34_RS22215 ENOG4105CC9 acyl-Coa dehydrogenase G6N34_RS22220 ENOG4105CD3 dihydroorotase G6N34_RS22230 ENOG4105E39 Enoyl-CoA hydratase G6N34_RS22240 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) G6N34_RS22265 ENOG4107R13 MMPL domain protein G6N34_RS22290 ENOG4108TAG Histidine kinase G6N34_RS22310 ENOG4107WA4 MmpL domain-containing protein G6N34_RS22320 ENOG4105K4P CoA-binding domain protein G6N34_RS22335 ENOG4105C9K Endothelin-converting enzyme 1 G6N34_RS22345 ENOG4105C26 Dehydrogenase G6N34_RS22350 ENOG4105S7A ErfK ybiS ycfS ynhG family protein G6N34_RS22360 ENOG4105VPX protein, conserved in bacteria G6N34_RS22370 ENOG4105C01 Dihydroxy-acid dehydratase G6N34_RS22440 ENOG4108M24 von Willebrand factor, type A G6N34_RS22465 ENOG4105EC2 ftsk spoIIIe G6N34_RS22515 ENOG4105E5G Alpha beta hydrolase fold G6N34_RS22525 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) G6N34_RS22540 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes G6N34_RS22605 ENOG4105E1F short-chain dehydrogenase reductase G6N34_RS22610 ENOG4105XPP Protein of unknown function (DUF1275) G6N34_RS22670 ENOG4105CY3 ABC transporter, permease G6N34_RS22680 ENOG4108WYP Transcriptional regulator G6N34_RS22690 ENOG4108R86 Transcriptional regulator G6N34_RS22700 ENOG4108IY8 ABC, transporter G6N34_RS22705 ENOG4106FTQ Taurine ABC transporter, periplasmic G6N34_RS22710 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component G6N34_RS22720 ENOG4105CSH Transporter G6N34_RS22725 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) G6N34_RS22730 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) G6N34_RS22740 ENOG4105C1G acyl-Coa dehydrogenase G6N34_RS22745 ENOG4105M2Z protein tyrosine serine phosphatase G6N34_RS22755 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic G6N34_RS22775 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr G6N34_RS22780 ENOG4105C26 Dehydrogenase G6N34_RS22785 ENOG4108UGJ Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) G6N34_RS22805 ENOG4105EUB pirin domain protein G6N34_RS22810 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) G6N34_RS22815 ENOG4105E98 transcriptional regulator DeoR family G6N34_RS22820 ENOG4105DE4 1-phosphofructokinase G6N34_RS22825 ENOG4105DM4 PTS System G6N34_RS22830 ENOG4105KRI phosphocarrier protein (HPr G6N34_RS22855 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction G6N34_RS22900 ENOG4105GSW G6N34_RS22975 ENOG4107R50 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) G6N34_RS23005 ENOG410905P Pyridoxamine 5-phosphate G6N34_RS23010 ENOG4105C0R drug resistance transporter emrb qaca subfamily G6N34_RS23055 ENOG4105E2A Dehydrogenase G6N34_RS23085 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) G6N34_RS23090 ENOG4107R7Y intracellular protease Pfpi family G6N34_RS23100 ENOG4107UVD Beta-phosphoglucomutase family hydrolase G6N34_RS23115 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 G6N34_RS23150 ENOG4107VQS DivIVA family G6N34_RS23165 ENOG4105IYB L-carnitine dehydratase bile acid-inducible protein F G6N34_RS23175 ENOG4108R85 Short chain dehydrogenase G6N34_RS23200 ENOG4107QKA exodeoxyribonuclease V beta G6N34_RS23205 ENOG4105DSY exodeoxyribonuclease V, gamma G6N34_RS23230 ENOG41070F3 Catalyzes the ATP-dependent phosphorylation of maltose to maltose 1-phosphate. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, GlgE and GlgB (By similarity) G6N34_RS23235 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) G6N34_RS23295 ENOG4105CEY Amp-dependent synthetase and ligase G6N34_RS23310 ENOG4107RN6 Monooxygenase G6N34_RS23325 ENOG4105D2B acyl-CoA dehydrogenase G6N34_RS23335 ENOG4105CNV Aldolase G6N34_RS23340 ENOG4105CPQ Dehydrogenase G6N34_RS23375 ENOG4105X7H acyl-CoA dehydrogenase G6N34_RS23385 ENOG4105D7N magnesium and cobalt transport protein CorA G6N34_RS23395 ENOG4105FF0 ErfK YbiS YcfS YnhG G6N34_RS23410 ENOG4108RZE Tetr family transcriptional regulator G6N34_RS23415 ENOG4105CHR reductase G6N34_RS23430 ENOG4105CSH Transporter G6N34_RS23445 ENOG4105D2B acyl-CoA dehydrogenase G6N34_RS23450 ENOG4105CC9 acyl-Coa dehydrogenase G6N34_RS23460 ENOG4105D2B acyl-CoA dehydrogenase G6N34_RS23470 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr G6N34_RS23475 ENOG4107R5W Monooxygenase G6N34_RS23490 ENOG4105CHR reductase G6N34_RS23500 ENOG4105FDP GntR family transcriptional regulator G6N34_RS23505 ENOG4105CEY Amp-dependent synthetase and ligase G6N34_RS23515 ENOG4105CEY Amp-dependent synthetase and ligase G6N34_RS23540 ENOG41060BG Tetr family transcriptional regulator G6N34_RS23575 ENOG4105EMU Dehydrogenase G6N34_RS23595 ENOG4107QX3 carboxylase G6N34_RS23600 ENOG4105D2B acyl-CoA dehydrogenase G6N34_RS23605 ENOG4105D2B acyl-CoA dehydrogenase G6N34_RS23625 ENOG4105CQ7 ATP-dependent helicase G6N34_RS23645 ENOG4105CKW Inner membrane protein yedI G6N34_RS23690 ENOG4105FP9 thiamine pyrophosphate G6N34_RS23720 ENOG4105NPE arsR family transcriptional regulator G6N34_RS23730 ENOG41061TZ Short-chain dehydrogenase reductase Sdr G6N34_RS23765 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) G6N34_RS23785 ENOG41076PI Short-chain dehydrogenase reductase Sdr G6N34_RS23810 ENOG41076PI Short-chain dehydrogenase reductase Sdr G6N34_RS23815 ENOG4107RN3 metallophosphoesterase G6N34_RS23835 ENOG4105CH6 catalase G6N34_RS23855 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) G6N34_RS23870 ENOG4105CHR reductase G6N34_RS23880 ENOG4105CMR udp-glucose 4-epimerase G6N34_RS23885 ENOG4108JGH Tetr family transcriptional regulator G6N34_RS23890 ENOG4105CEY Amp-dependent synthetase and ligase G6N34_RS23910 ENOG4105CEY Amp-dependent synthetase and ligase G6N34_RS23925 ENOG4105D2B acyl-CoA dehydrogenase G6N34_RS23935 ENOG4105CGU Enoyl-CoA hydratase G6N34_RS23945 ENOG4106A3M Cytochrome p-450 G6N34_RS23955 ENOG4107YCY Transcriptional regulator G6N34_RS23960 ENOG4105CEY Amp-dependent synthetase and ligase G6N34_RS23970 ENOG4105CHU acetyl-coa acetyltransferase G6N34_RS23980 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G6N34_RS24040 ENOG4105CY3 ABC transporter, permease G6N34_RS24060 ENOG4105CC9 acyl-Coa dehydrogenase G6N34_RS24065 ENOG4105D2B acyl-CoA dehydrogenase G6N34_RS24080 ENOG4105CEY Amp-dependent synthetase and ligase G6N34_RS24115 ENOG4107QKR Dehydrogenase G6N34_RS24120 ENOG4105CPP Dehydrogenase, E1 component G6N34_RS24125 ENOG4107R0V Pyruvate dehydrogenase G6N34_RS24135 ENOG41090TK Short-chain dehydrogenase reductase Sdr G6N34_RS24150 ENOG4105CHR reductase G6N34_RS24165 ENOG4107TFQ Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) G6N34_RS24170 ENOG41076PI Short-chain dehydrogenase reductase Sdr G6N34_RS24190 ENOG4105K56 Transcriptional regulator G6N34_RS24250 ENOG4108RKS Short-chain dehydrogenase reductase Sdr G6N34_RS24255 ENOG4105E5D amino acid G6N34_RS24270 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) G6N34_RS24275 ENOG4108JJB ABC transporter G6N34_RS24280 ENOG4107ZYJ bioY protein G6N34_RS24290 ENOG4105GVF (ABC) transporter G6N34_RS24295 ENOG4105CSH Transporter G6N34_RS24300 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) G6N34_RS24325 ENOG4107RCI amp-dependent synthetase and ligase G6N34_RS24355 ENOG4108YRB methyltransferase G6N34_RS24405 ENOG4105CQB FAD linked oxidase domain protein G6N34_RS24420 ENOG4105CHR reductase G6N34_RS24425 ENOG4105E2Y ABC, transporter G6N34_RS24435 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component G6N34_RS24450 ENOG4105WEF catalase G6N34_RS24460 ENOG4105E2A Dehydrogenase G6N34_RS24465 ENOG4105C3M thioredoxin reductase G6N34_RS24495 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) G6N34_RS24500 ENOG4105CHR reductase G6N34_RS24510 ENOG4105C5H ABC transporter G6N34_RS24525 ENOG410900P UPF0336 protein G6N34_RS24550 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein G6N34_RS24565 ENOG4105MWK D-amino acid dehydrogenase, small subunit G6N34_RS24585 ENOG4105C1G acyl-Coa dehydrogenase G6N34_RS24590 ENOG4105CC9 acyl-Coa dehydrogenase G6N34_RS24595 ENOG4105CS1 NAD(P)H quinone oxidoreductase G6N34_RS24605 ENOG4105CUB amino acid G6N34_RS24640 ENOG4105D01 (LipO)protein G6N34_RS24645 ENOG4108UMI ABC transporter, permease G6N34_RS24680 ENOG4105CSH Transporter G6N34_RS24685 ENOG4108SGK Tetr family transcriptional regulator G6N34_RS24700 ENOG4107S2E monooxygenase G6N34_RS24715 ENOG4105H37 Glyoxalase Bleomycin resistance protein (Dioxygenase G6N34_RS24720 ENOG4107HP6 Transcriptional regulator G6N34_RS24730 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase G6N34_RS24745 ENOG4105H9W Short-chain dehydrogenase reductase Sdr G6N34_RS24765 ENOG4105H9W Short-chain dehydrogenase reductase Sdr G6N34_RS24790 ENOG4105HMD G6N34_RS24805 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein G6N34_RS24820 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein G6N34_RS24875 ENOG4105CY3 ABC transporter, permease G6N34_RS24880 ENOG4105CHR reductase G6N34_RS24910 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr G6N34_RS24915 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) G6N34_RS24925 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) G6N34_RS24930 ENOG4108IG5 Transcriptional regulator G6N34_RS24975 ENOG4107RUY (E1 component), alpha subunit G6N34_RS24985 ENOG4105CQB FAD linked oxidase domain protein G6N34_RS24995 ENOG4105MWK D-amino acid dehydrogenase, small subunit G6N34_RS25000 ENOG4105C26 Dehydrogenase G6N34_RS25005 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase G6N34_RS25010 ENOG4105CHR reductase G6N34_RS25050 ENOG41060BG Tetr family transcriptional regulator G6N34_RS25060 ENOG4108XFH Transcriptional regulator G6N34_RS25065 ENOG4105F6U Short-chain dehydrogenase reductase Sdr G6N34_RS25075 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase G6N34_RS25080 ENOG4105K63 Thioredoxin G6N34_RS25085 ENOG4105CBC glutamate synthase G6N34_RS25130 ENOG4107S1E Beta-lactamase G6N34_RS25135 ENOG4105WH1 Two component transcriptional regulator luxr family G6N34_RS25185 ENOG4105H3G oxidoreductase G6N34_RS25220 ENOG4105C8Y Acetylornithine aminotransferase G6N34_RS25230 ENOG4108WKN secreted protein G6N34_RS25240 ENOG4107XI7 Tetr family transcriptional regulator G6N34_RS25245 ENOG4105CHR reductase G6N34_RS25255 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr G6N34_RS25270 ENOG4105DWF phosphomethylpyrimidine kinase G6N34_RS25305 ENOG4106A3M Cytochrome p-450 G6N34_RS25345 ENOG4105CBC glutamate synthase G6N34_RS25360 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr G6N34_RS25365 ENOG41067SE Tetr family transcriptional regulator G6N34_RS25380 ENOG4107U5X Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) G6N34_RS25395 ENOG4105CK2 sodium dicarboxylate symporter G6N34_RS25425 ENOG4108YIQ Alpha beta hydrolase G6N34_RS25430 ENOG4107XWI flavin reductase domain protein, FMN-binding G6N34_RS25465 ENOG4108Q27 Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate (By similarity) G6N34_RS25485 ENOG4107YH6 single-stranded DNA-binding protein G6N34_RS25490 ENOG410829C Binds together with S18 to 16S ribosomal RNA (By similarity) G6N34_RS25495 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) G6N34_RS25500 ENOG4105EHG Permease protein G6N34_RS25505 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) G6N34_RS25520 ENOG4105BZ4 penicillin-binding protein G6N34_RS25530 ENOG41061MJ Domain of unknown function (DUF1707) G6N34_RS25540 ENOG4105CZA synthase G6N34_RS25560 ENOG4105EAD ABC transporter G6N34_RS25565 ENOG4105CDA abc transporter atp-binding protein G6N34_RS25580 ENOG4105EMU Dehydrogenase G6N34_RS25585 ENOG4105C8T Leucyl-tRNA synthetase G6N34_RS25590 ENOG41064CH Probable lipoprotein LpqN G6N34_RS25665 ENOG4108E1C hydrolase G6N34_RS25680 ENOG4107QJE Chromosome Partitioning Protein G6N34_RS25685 ENOG4107XUG Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) G6N34_RS25695 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins G6N34_RS25705 ENOG4108CDF RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) G6N34_RS25710 ENOG41084CH 50S ribosomal protein l34 G6N34_RS25715 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) G6N34_RS25720 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) G6N34_RS25725 ENOG4108J5G 6-phosphogluconate dehydrogenase G6N34_RS25730 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) G6N34_RS25735 ENOG4105K7N UPF0232 protein G6N34_RS25740 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) G6N34_RS25760 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) G6N34_RS25815 ENOG4107TPY serine threonine protein kinase G6N34_RS25820 ENOG4105CJN penicillin-binding protein G6N34_RS25835 ENOG4105HZM Fha domain containing protein G6N34_RS25840 ENOG4105TV9 FHA Domain-Containing protein G6N34_RS25860 ENOG4107X2D transcriptional regulator, merr family G6N34_RS25875 ENOG4107RCI amp-dependent synthetase and ligase G6N34_RS25890 ENOG4105M5P UPF0310 protein G6N34_RS25910 ENOG4105ZXU NLP P60 protein G6N34_RS26025 ENOG4105CBC glutamate synthase G6N34_RS26040 ENOG4105DCG PHP domain protein G6N34_RS26045 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) G6N34_RS26050 ENOG41060BG Tetr family transcriptional regulator G6N34_RS26055 ENOG4105CT3 Monooxygenase G6N34_RS26060 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) G6N34_RS26100 ENOG4108VEQ Superoxide dismutase G6N34_RS26125 ENOG4107YEV ferritin G6N34_RS26130 ENOG4108KGH TRANSCRIPTIONal G6N34_RS26150 ENOG4105CQC Prephenate dehydratase G6N34_RS26170 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) G6N34_RS26200 ENOG4107B57 rieske 2fe-2S domain-containing protein G6N34_RS26205 ENOG4105PSQ Acyl-transferase G6N34_RS26235 ENOG410602S Transferase G6N34_RS26250 ENOG4107ISF Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component the mycobacterial cell wall. Catalyzes the transfer of arabinofuranosyl (Araf) residues residue from the sugar donor beta-D-arabinofuranosyl-1-monophosphoryldecaprenol (DPA) to the arabinan domain to form terminal beta-(1- 2)-linked Araf residues, which marks the end point for AG arabinan biosynthesis before decoration with mycolic acids G6N34_RS26290 ENOG4105D8K carboxyl transferase G6N34_RS26315 ENOG4105J1Z Arabinosyltransferase G6N34_RS26320 ENOG4108NUW Cell wall arabinan synthesis protein G6N34_RS26325 ENOG4105J1Z Arabinosyltransferase G6N34_RS26335 ENOG4108RG3 short-chain dehydrogenase reductase G6N34_RS26340 ENOG4105IQ5 FAD linked oxidase domain protein G6N34_RS26355 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family G6N34_RS26360 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) G6N34_RS26395 ENOG4108MKI Glycosyl transferase, family 2 G6N34_RS26405 ENOG4108VC7 Protein of unknown function (DUF2587) G6N34_RS26440 ENOG4108X6U May play a role in the intracellular transport of hydrophobic ligands G6N34_RS26455 ENOG4105CIH Imidazole acetol-phosphate transaminase G6N34_RS26475 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) G6N34_RS26490 ENOG4105CHR reductase G6N34_RS26495 ENOG4105C1G acyl-Coa dehydrogenase G6N34_RS26515 ENOG4105CK6 Two component transcriptional regulator (Winged helix family G6N34_RS26520 ENOG4105BZU Histidine kinase G6N34_RS26525 ENOG4105EDW glycosyl transferase, family 39 G6N34_RS26535 ENOG4105EDW glycosyl transferase, family 39 G6N34_RS26535 ENOG4105EDW glycosyl transferase, family 39 G6N34_RS26540 ENOG4105EUZ Beta-lactamase domain protein G6N34_RS26565 ENOG41060H3 Protein of unknown function (DUF1049) G6N34_RS26580 ENOG4105E90 ABC transporter G6N34_RS26585 ENOG4105E90 ABC transporter G6N34_RS26595 ENOG4105EVN Prephenate dehydrogenase G6N34_RS26605 ENOG4108Z6B deaminase G6N34_RS26615 ENOG4107SFI Major Facilitator superfamily G6N34_RS26625 ENOG4108JGH Tetr family transcriptional regulator G6N34_RS26670 ENOG4105C26 Dehydrogenase G6N34_RS26675 ENOG4105CJP fad dependent oxidoreductase G6N34_RS26690 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) G6N34_RS26715 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) G6N34_RS26735 ENOG4105CDA abc transporter atp-binding protein G6N34_RS26740 ENOG4105DRP amino acid AbC transporter G6N34_RS26745 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) G6N34_RS26760 ENOG4107YCY Transcriptional regulator G6N34_RS26800 ENOG4107PE3 Mammalian cell entry related domain protein G6N34_RS26835 ENOG4105GN4 DNA ligase G6N34_RS26840 ENOG4105DQE DNA ligase G6N34_RS26845 ENOG4105C0H protease G6N34_RS26870 ENOG4105XT2 Transcriptional regulator G6N34_RS26880 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase G6N34_RS26895 ENOG4108RU2 n-acetylmuramoyl-l-alanine amidase G6N34_RS26900 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) G6N34_RS26905 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) G6N34_RS26915 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) G6N34_RS26920 ENOG4105DFU Cell wall formation (By similarity) G6N34_RS26935 ENOG4105ENY Ethanolamine utilization protein eutH G6N34_RS26940 ENOG4105CHR reductase G6N34_RS26945 ENOG41076PI Short-chain dehydrogenase reductase Sdr G6N34_RS26950 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) G6N34_RS26975 ENOG4105C7I Dehydrogenase G6N34_RS27010 ENOG4105MPZ Pfam:DUF1023 G6N34_RS27030 ENOG4105CBC glutamate synthase G6N34_RS27035 ENOG4105M90 Glutamate synthase alpha subunit domain protein G6N34_RS27040 ENOG4105EYU Glutamine amido-transferase G6N34_RS27060 ENOG4105CFH Aspartokinase G6N34_RS27065 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) G6N34_RS27070 ENOG4108NJC G6N34_RS27080 ENOG4108ZHJ Organic hydroperoxide resistance protein G6N34_RS27090 ENOG4105D1K glutamate--cysteine ligase G6N34_RS27095 ENOG4105E46 N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process G6N34_RS27105 ENOG41067HS methyltransferase G6N34_RS27110 ENOG4105C92 Aminotransferase class V G6N34_RS27145 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) G6N34_RS27150 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) G6N34_RS27165 ENOG4105C57 major facilitator superfamily G6N34_RS27170 ENOG4105YIP Tetr family transcriptional regulator G6N34_RS27190 ENOG4105C7R Atpase associated with various cellular activities aaa_3 G6N34_RS27195 ENOG4108WQ6 secreted protein G6N34_RS27215 ENOG4105C29 acyl-CoA thioesterase G6N34_RS27235 ENOG4105H3G oxidoreductase G6N34_RS27295 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) G6N34_RS27320 ENOG4105P8F nudix hydrolase G6N34_RS27355 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) G6N34_RS27380 ENOG4106UW1 Major Facilitator superfamily G6N34_RS27395 ENOG4105DVW rieske (2Fe-2S) G6N34_RS27410 ENOG4107S2E monooxygenase G6N34_RS27415 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) G6N34_RS27420 ENOG4105C26 Dehydrogenase G6N34_RS27460 ENOG4105DVW rieske (2Fe-2S) G6N34_RS27465 ENOG4107EXU Short-chain dehydrogenase reductase Sdr G6N34_RS27475 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) G6N34_RS27480 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) G6N34_RS27490 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) G6N34_RS27525 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity)