locus-tag	class	description
C1S78_RS00010	COG0592	DNA-directed DNA polymerase activity
C1S78_RS00015	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
C1S78_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C1S78_RS00025	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
C1S78_RS00030	COG0187	DNA topoisomerase II activity
C1S78_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C1S78_RS00095	COG0515	serine threonine protein kinase
C1S78_RS00100	COG0768	penicillin binding
C1S78_RS00115	COG1716	ATPase activity
C1S78_RS00120	COG1716	ATPase activity
C1S78_RS00140	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C1S78_RS00145	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C1S78_RS00165	COG4221	oxidoreductase activity
C1S78_RS00240	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C1S78_RS00310	COG0464	growth
C1S78_RS00325	COG1674	ftsk spoiiie
C1S78_RS00340	COG4842	Belongs to the WXG100 family
C1S78_RS00345	COG4842	Belongs to the WXG100 family
C1S78_RS00370	COG1716	ATPase activity
C1S78_RS00370	COG1131	(ABC) transporter
C1S78_RS00370	COG0842	Transport permease protein
C1S78_RS00405	COG1404	Belongs to the peptidase S8 family
C1S78_RS00415	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C1S78_RS00415	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C1S78_RS00415	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C1S78_RS00420	COG1105	Belongs to the carbohydrate kinase PfkB family
C1S78_RS00430	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C1S78_RS00450	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
C1S78_RS00455	COG1012	belongs to the aldehyde dehydrogenase family
C1S78_RS00460	COG1028	Short-chain dehydrogenase reductase Sdr
C1S78_RS00465	COG1028	Short-chain dehydrogenase reductase Sdr
C1S78_RS00465	COG0604	alcohol dehydrogenase
C1S78_RS00465	COG3321	synthase
C1S78_RS00480	COG2365	Tyrosine phosphatase family
C1S78_RS00485	COG1960	acyl-CoA dehydrogenase activity
C1S78_RS00510	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C1S78_RS00540	COG4585	Histidine kinase
C1S78_RS00545	COG2267	carboxylic ester hydrolase activity
C1S78_RS00550	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
C1S78_RS00570	COG1309	transcriptional regulator
C1S78_RS00575	COG1960	acyl-CoA dehydrogenase activity
C1S78_RS00605	COG3415	Transposase
C1S78_RS00605	COG2801	Transposase and inactivated derivatives
C1S78_RS00620	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C1S78_RS00625	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C1S78_RS00730	COG2267	carboxylic ester hydrolase activity
C1S78_RS00755	COG4122	O-methyltransferase activity
C1S78_RS00780	COG3268	Saccharopine dehydrogenase
C1S78_RS00800	COG1937	Protein conserved in bacteria
C1S78_RS00825	COG1376	ErfK ybiS ycfS ynhG family protein
C1S78_RS00830	COG3590	peptidase
C1S78_RS00850	COG2409	Drug exporters of the RND superfamily
C1S78_RS00885	COG2409	Drug exporters of the RND superfamily
C1S78_RS00905	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
C1S78_RS00915	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
C1S78_RS00925	COG2030	dehydratase
C1S78_RS00945	COG0318	PFAM AMP-dependent synthetase and ligase
C1S78_RS00985	COG1960	acyl-CoA dehydrogenase activity
C1S78_RS00990	COG0657	acetylesterase activity
C1S78_RS01000	COG0657	acetylesterase activity
C1S78_RS01005	COG0318	PFAM AMP-dependent synthetase and ligase
C1S78_RS01030	COG1960	acyl-CoA dehydrogenase activity
C1S78_RS01065	COG0297	glycogen (starch) synthase activity
C1S78_RS01070	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C1S78_RS01095	COG4981	capsule polysaccharide biosynthetic process
C1S78_RS01105	COG1472	Belongs to the glycosyl hydrolase 3 family
C1S78_RS01110	COG1309	transcriptional regulator
C1S78_RS01120	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C1S78_RS01125	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
C1S78_RS01135	COG2030	dehydratase
C1S78_RS01140	COG1028	Short-chain dehydrogenase reductase Sdr
C1S78_RS01145	COG0183	Belongs to the thiolase family
C1S78_RS01155	COG0789	Transcriptional regulator
C1S78_RS01170	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C1S78_RS01195	COG0318	PFAM AMP-dependent synthetase and ligase
C1S78_RS01205	COG1960	acyl-CoA dehydrogenase activity
C1S78_RS01215	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C1S78_RS01220	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
C1S78_RS01225	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C1S78_RS01225	COG2755	lipolytic protein G-D-S-L family
C1S78_RS01230	COG0438	transferase activity, transferring glycosyl groups
C1S78_RS01240	COG0438	transferase activity, transferring glycosyl groups
C1S78_RS01260	COG2244	polysaccharide biosynthetic process
C1S78_RS01280	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C1S78_RS01280	COG2755	lipolytic protein G-D-S-L family
C1S78_RS01295	COG2755	lipolytic protein G-D-S-L family
C1S78_RS01295	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C1S78_RS01310	COG0489	protein tyrosine kinase activity
C1S78_RS01335	COG5651	PPE family
C1S78_RS01420	COG2146	nitrite reductase [NAD(P)H] activity
C1S78_RS01420	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C1S78_RS01455	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
C1S78_RS01465	COG4607	ABC-type enterochelin transport system periplasmic component
C1S78_RS01480	COG1752	Esterase of the alpha-beta hydrolase superfamily
C1S78_RS01485	COG1376	ErfK ybiS ycfS ynhG family protein
C1S78_RS01515	COG5651	PPE family
C1S78_RS01540	COG0789	Transcriptional regulator
C1S78_RS01560	COG0318	PFAM AMP-dependent synthetase and ligase
C1S78_RS01570	COG1960	acyl-CoA dehydrogenase activity
C1S78_RS01575	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C1S78_RS01595	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C1S78_RS01625	COG0464	growth
C1S78_RS01630	COG3266	domain, Protein
C1S78_RS01635	COG1674	ftsk spoiiie
C1S78_RS01655	COG4842	Belongs to the WXG100 family
C1S78_RS01670	COG1404	Belongs to the peptidase S8 family
C1S78_RS01690	COG4106	trans-aconitate 2-methyltransferase activity
C1S78_RS01710	COG4424	Sulfotransferase
C1S78_RS01715	COG3119	arylsulfatase activity
C1S78_RS01720	COG0494	nUDIX hydrolase
C1S78_RS01775	COG0640	Transcriptional regulator
C1S78_RS01820	COG1309	transcriptional regulator
C1S78_RS01830	COG0110	maltose O-acetyltransferase activity
C1S78_RS01850	COG4638	Rieske (2fe-2S)
C1S78_RS01880	COG2032	superoxide dismutase activity
C1S78_RS01895	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
C1S78_RS01935	COG2181	nitrate reductase activity
C1S78_RS01935	COG0247	lactate metabolic process
C1S78_RS02025	COG2072	flavoprotein involved in K transport
C1S78_RS02030	COG1403	HNH endonuclease
C1S78_RS02035	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C1S78_RS02050	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C1S78_RS02060	COG0789	Transcriptional regulator
C1S78_RS02065	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C1S78_RS02090	COG0542	response to heat
C1S78_RS02095	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C1S78_RS02120	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C1S78_RS02155	COG0640	Transcriptional regulator
C1S78_RS02165	COG0798	PFAM Bile acid sodium symporter
C1S78_RS02170	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C1S78_RS02230	COG0745	RESPONSE REGULATOR receiver
C1S78_RS02235	COG2205	protein histidine kinase activity
C1S78_RS02265	COG0183	Belongs to the thiolase family
C1S78_RS02270	COG2409	Drug exporters of the RND superfamily
C1S78_RS02305	COG2124	cytochrome p450
C1S78_RS02325	COG1012	belongs to the aldehyde dehydrogenase family
C1S78_RS02370	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C1S78_RS02380	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C1S78_RS02395	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C1S78_RS02400	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C1S78_RS02410	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C1S78_RS02450	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C1S78_RS02455	COG0047	phosphoribosylformylglycinamidine synthase activity
C1S78_RS02465	COG2837	iron assimilation
C1S78_RS02470	COG1362	aminopeptidase activity
C1S78_RS02530	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C1S78_RS02535	COG3959	Transketolase, thiamine diphosphate binding domain
C1S78_RS02545	COG1012	belongs to the aldehyde dehydrogenase family
C1S78_RS02555	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C1S78_RS02570	COG4044	May play a role in the intracellular transport of hydrophobic ligands
C1S78_RS02580	COG2897	thiosulfate sulfurtransferase activity
C1S78_RS02600	COG0745	RESPONSE REGULATOR receiver
C1S78_RS02605	COG0456	acetyltransferase
C1S78_RS02625	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C1S78_RS02635	COG1846	Transcriptional regulator
C1S78_RS02670	COG2346	COG2346, Truncated hemoglobins
C1S78_RS02675	COG0515	serine threonine protein kinase
C1S78_RS02690	COG1846	Transcriptional regulator
C1S78_RS02720	COG0300	oxidoreductase activity
C1S78_RS02725	COG0789	Transcriptional regulator
C1S78_RS02735	COG4974	Belongs to the 'phage' integrase family
C1S78_RS03135	COG3723	Recombinational DNA repair protein, rece pathway
C1S78_RS03215	COG0671	phosphoesterase, PA-phosphatase related
C1S78_RS03225	COG0745	RESPONSE REGULATOR receiver
C1S78_RS03230	COG2205	protein histidine kinase activity
C1S78_RS03285	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C1S78_RS03315	COG1233	COG1233 Phytoene dehydrogenase and related
C1S78_RS03325	COG1953	Uracil, thiamine, allantoin
C1S78_RS03340	COG4266	Belongs to the allantoicase family
C1S78_RS03350	COG0657	acetylesterase activity
C1S78_RS03355	COG1902	pentaerythritol trinitrate reductase activity
C1S78_RS03360	COG0183	Belongs to the thiolase family
C1S78_RS03365	COG1024	Enoyl-CoA hydratase
C1S78_RS03365	COG1250	3-hydroxyacyl-CoA dehydrogenase
C1S78_RS03415	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C1S78_RS03460	COG0521	Mo-molybdopterin cofactor biosynthetic process
C1S78_RS03480	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C1S78_RS03485	COG3304	Inner membrane component domain
C1S78_RS03490	COG1278	Cold shock
C1S78_RS03495	COG0435	Glutathione S-transferase
C1S78_RS03505	COG2814	Major facilitator Superfamily
C1S78_RS03575	COG0259	pyridoxamine-phosphate oxidase activity
C1S78_RS03595	COG1846	Transcriptional regulator
C1S78_RS03600	COG0545	Peptidyl-prolyl cis-trans isomerase
C1S78_RS03635	COG1132	(ABC) transporter
C1S78_RS03640	COG1132	(ABC) transporter
C1S78_RS03645	COG2197	response regulator
C1S78_RS03650	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C1S78_RS03655	COG0318	PFAM AMP-dependent synthetase and ligase
C1S78_RS03675	COG1414	Transcriptional regulator
C1S78_RS03685	COG1012	belongs to the aldehyde dehydrogenase family
C1S78_RS03700	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C1S78_RS03720	COG1024	Enoyl-CoA hydratase
C1S78_RS03730	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C1S78_RS03750	COG1733	regulation of RNA biosynthetic process
C1S78_RS03760	COG0183	Belongs to the thiolase family
C1S78_RS03795	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C1S78_RS03800	COG0471	metal ion transport
C1S78_RS03800	COG0490	domain, Protein
C1S78_RS03880	COG0640	Transcriptional regulator
C1S78_RS03895	COG0640	Transcriptional regulator
C1S78_RS03905	COG1773	rubredoxin
C1S78_RS03920	COG1960	acyl-CoA dehydrogenase activity
C1S78_RS03925	COG0300	oxidoreductase activity
C1S78_RS03930	COG1012	belongs to the aldehyde dehydrogenase family
C1S78_RS03950	COG0318	PFAM AMP-dependent synthetase and ligase
C1S78_RS03965	COG1028	Short-chain dehydrogenase reductase Sdr
C1S78_RS03970	COG1028	Short-chain dehydrogenase reductase Sdr
C1S78_RS03975	COG0318	PFAM AMP-dependent synthetase and ligase
C1S78_RS03990	COG2301	Belongs to the HpcH HpaI aldolase family
C1S78_RS03995	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
C1S78_RS04020	COG1024	Enoyl-CoA hydratase
C1S78_RS04025	COG4638	Rieske (2fe-2S)
C1S78_RS04030	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
C1S78_RS04040	COG0427	acetyl-CoA hydrolase
C1S78_RS04045	COG0183	Belongs to the thiolase family
C1S78_RS04055	COG0183	Belongs to the thiolase family
C1S78_RS04080	COG0183	Belongs to the thiolase family
C1S78_RS04090	COG2508	Transcriptional regulator
C1S78_RS04105	COG0789	Transcriptional regulator
C1S78_RS04110	COG0723	plastoquinol--plastocyanin reductase activity
C1S78_RS04125	COG0693	protein deglycase activity
C1S78_RS04145	COG3486	L-lysine 6-monooxygenase (NADPH) activity
C1S78_RS04165	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
C1S78_RS04170	COG3285	dna ligase
C1S78_RS04170	COG1793	dna ligase
C1S78_RS04175	COG0328	RNA-DNA hybrid ribonuclease activity
C1S78_RS04195	COG1960	acyl-CoA dehydrogenase activity
C1S78_RS04220	COG1950	PFAM Membrane protein of
C1S78_RS04225	COG1289	transmembrane transporter activity
C1S78_RS04230	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C1S78_RS04235	COG1605	Chorismate mutase
C1S78_RS04245	COG0166	Belongs to the GPI family
C1S78_RS04275	COG0045	succinate-CoA ligase (ADP-forming) activity
C1S78_RS04365	COG0579	oxidoreductase
C1S78_RS04380	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
C1S78_RS04395	COG1024	Enoyl-CoA hydratase
C1S78_RS04410	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C1S78_RS04430	COG0745	RESPONSE REGULATOR receiver
C1S78_RS04440	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C1S78_RS04445	COG0315	cyclic pyranopterin monophosphate synthase activity
C1S78_RS04445	COG0521	Mo-molybdopterin cofactor biosynthetic process
C1S78_RS04470	COG1970	mechanosensitive ion channel activity
C1S78_RS04485	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C1S78_RS04550	COG1309	transcriptional regulator
C1S78_RS04585	COG0254	rRNA binding
C1S78_RS04590	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C1S78_RS04590	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C1S78_RS04595	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C1S78_RS04630	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C1S78_RS04640	COG1252	NADH dehydrogenase
C1S78_RS04645	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C1S78_RS04655	COG0084	hydrolase, TatD family'
C1S78_RS04660	COG3583	domain protein
C1S78_RS04670	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C1S78_RS04675	COG0318	PFAM AMP-dependent synthetase and ligase
C1S78_RS04690	COG0193	aminoacyl-tRNA hydrolase activity
C1S78_RS04720	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C1S78_RS04730	COG1309	transcriptional regulator
C1S78_RS04745	COG3956	TIGRFAM MazG family protein
C1S78_RS04765	COG2837	iron assimilation
C1S78_RS04825	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
C1S78_RS04830	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
C1S78_RS04835	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
C1S78_RS04845	COG0318	PFAM AMP-dependent synthetase and ligase
C1S78_RS04850	COG0427	acetyl-CoA hydrolase
C1S78_RS04870	COG4941	Belongs to the sigma-70 factor family
C1S78_RS04885	COG2267	carboxylic ester hydrolase activity
C1S78_RS04965	COG1216	Glycosyl transferase, family 2
C1S78_RS05025	COG3290	protein histidine kinase activity
C1S78_RS05030	COG1301	dicarboxylic acid transport
C1S78_RS05045	COG0318	PFAM AMP-dependent synthetase and ligase
C1S78_RS05055	COG1309	transcriptional regulator
C1S78_RS05060	COG0183	Belongs to the thiolase family
C1S78_RS05065	COG3804	dihydrodipicolinate reductase
C1S78_RS05070	COG1063	alcohol dehydrogenase
C1S78_RS05095	COG1316	TRANSCRIPTIONal
C1S78_RS05125	COG1024	Enoyl-CoA hydratase
C1S78_RS05135	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
C1S78_RS05145	COG0183	Belongs to the thiolase family
C1S78_RS05150	COG2755	lipolytic protein G-D-S-L family
C1S78_RS05155	COG0657	acetylesterase activity
C1S78_RS05190	COG1960	acyl-CoA dehydrogenase activity
C1S78_RS05215	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C1S78_RS05225	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C1S78_RS05235	COG1331	Highly conserved protein containing a thioredoxin domain
C1S78_RS05250	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C1S78_RS05270	COG0572	uridine kinase
C1S78_RS05285	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C1S78_RS05295	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C1S78_RS05310	COG0726	polysaccharide deacetylase
C1S78_RS05395	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C1S78_RS05405	COG3119	arylsulfatase activity
C1S78_RS05445	COG0012	GTP binding
C1S78_RS05500	COG2226	methyltransferase
C1S78_RS05565	COG2186	Transcriptional regulator
C1S78_RS05570	COG0183	Belongs to the thiolase family
C1S78_RS05575	COG1024	Enoyl-CoA hydratase
C1S78_RS05580	COG1960	acyl-CoA dehydrogenase activity
C1S78_RS05605	COG1024	Enoyl-CoA hydratase
C1S78_RS05610	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C1S78_RS05625	COG1960	acyl-CoA dehydrogenase activity
C1S78_RS05630	COG2409	Drug exporters of the RND superfamily
C1S78_RS05640	COG2226	methyltransferase
C1S78_RS05645	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C1S78_RS05650	COG2188	Transcriptional regulator
C1S78_RS05730	COG2072	flavoprotein involved in K transport
C1S78_RS05735	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C1S78_RS05735	COG2124	cytochrome p450
C1S78_RS05740	COG2233	PERMEase
C1S78_RS05750	COG3467	pyridoxamine 5'-phosphate
C1S78_RS05770	COG1396	sequence-specific DNA binding
C1S78_RS05780	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C1S78_RS05815	COG1028	Short-chain dehydrogenase reductase Sdr
C1S78_RS05835	COG1051	belongs to the nudix hydrolase family
C1S78_RS05840	COG2154	pterin-4-alpha-carbinolamine dehydratase
C1S78_RS05865	COG1217	gtp-binding protein TYPA
C1S78_RS05875	COG0747	negative chemotaxis
C1S78_RS05885	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C1S78_RS05910	COG1902	pentaerythritol trinitrate reductase activity
C1S78_RS05910	COG0446	pyridine nucleotide-disulphide oxidoreductase
C1S78_RS05920	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
C1S78_RS05935	COG0583	DNA-binding transcription factor activity
C1S78_RS05955	COG0494	nUDIX hydrolase
C1S78_RS05960	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C1S78_RS05965	COG0318	PFAM AMP-dependent synthetase and ligase
C1S78_RS05980	COG2171	N-acyltransferase activity
C1S78_RS05990	COG1063	alcohol dehydrogenase
C1S78_RS06005	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C1S78_RS06015	COG0488	(ABC) transporter
C1S78_RS06030	COG1611	Belongs to the LOG family
C1S78_RS06035	COG0318	PFAM AMP-dependent synthetase and ligase
C1S78_RS06060	COG0463	Glycosyl transferase, family 2
C1S78_RS06070	COG0519	Catalyzes the synthesis of GMP from XMP
C1S78_RS06080	COG0297	glycogen (starch) synthase activity
C1S78_RS06085	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C1S78_RS06100	COG3559	Exporter of polyketide antibiotics
C1S78_RS06105	COG1131	(ABC) transporter
C1S78_RS06110	COG1309	transcriptional regulator
C1S78_RS06125	COG5662	AntiSigma factor
C1S78_RS06130	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C1S78_RS06135	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C1S78_RS06160	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C1S78_RS06180	COG2239	Acts as a magnesium transporter
C1S78_RS06190	COG3415	Transposase
C1S78_RS06190	COG2801	Transposase and inactivated derivatives
C1S78_RS06240	COG0598	Magnesium transport protein CorA
C1S78_RS06270	COG3220	belongs to the UPF0276 family
C1S78_RS06275	COG0508	dehydrogenase complex catalyzes the overall conversion of
C1S78_RS06275	COG0567	Dehydrogenase, E1 component
C1S78_RS06285	COG2814	Major facilitator Superfamily
C1S78_RS06355	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
C1S78_RS06370	COG0179	Fumarylacetoacetate (FAA) hydrolase
C1S78_RS06385	COG4221	oxidoreductase activity
C1S78_RS06395	COG0277	FAD linked oxidase domain protein
C1S78_RS06420	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C1S78_RS06585	COG0745	RESPONSE REGULATOR receiver
C1S78_RS06590	COG2205	protein histidine kinase activity
C1S78_RS06595	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C1S78_RS06600	COG1215	transferase activity, transferring glycosyl groups
C1S78_RS06605	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C1S78_RS06620	COG0175	sulfate reduction
C1S78_RS06690	COG2197	response regulator
C1S78_RS06695	COG4585	Histidine kinase
C1S78_RS06725	COG0018	arginyl-trna synthetase
C1S78_RS06730	COG0019	diaminopimelate decarboxylase activity
C1S78_RS06735	COG0460	homoserine dehydrogenase
C1S78_RS06740	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C1S78_RS06755	COG3415	Transposase
C1S78_RS06755	COG2801	Transposase and inactivated derivatives
C1S78_RS06760	COG1309	transcriptional regulator
C1S78_RS06765	COG0318	PFAM AMP-dependent synthetase and ligase
C1S78_RS06775	COG4941	Belongs to the sigma-70 factor family
C1S78_RS06780	COG0254	rRNA binding
C1S78_RS06785	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C1S78_RS06790	COG2890	protein-(glutamine-N5) methyltransferase activity
C1S78_RS06800	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C1S78_RS06810	COG0356	it plays a direct role in the translocation of protons across the membrane
C1S78_RS06815	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C1S78_RS06825	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C1S78_RS06825	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C1S78_RS06830	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C1S78_RS06835	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C1S78_RS06840	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C1S78_RS06845	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C1S78_RS06905	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
C1S78_RS06915	COG0346	lactoylglutathione lyase activity
C1S78_RS06920	COG0183	Belongs to the thiolase family
C1S78_RS06925	COG2409	Drug exporters of the RND superfamily
C1S78_RS06945	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C1S78_RS06950	COG0366	Alpha amylase catalytic
C1S78_RS06955	COG0058	SHG alpha-glucan phosphorylase activity
C1S78_RS06960	COG4257	antibiotic catabolic process
C1S78_RS06970	COG1846	Transcriptional regulator
C1S78_RS06980	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
C1S78_RS06985	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
C1S78_RS06995	COG3191	aminopeptidase activity
C1S78_RS07005	COG1234	tRNA 3'-trailer cleavage
C1S78_RS07010	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C1S78_RS07020	COG0730	response to heat
C1S78_RS07030	COG0596	Alpha beta hydrolase
C1S78_RS07085	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C1S78_RS07250	COG0668	transmembrane transport
C1S78_RS07275	COG1297	OPT oligopeptide transporter protein
C1S78_RS07280	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
C1S78_RS07290	COG0318	PFAM AMP-dependent synthetase and ligase
C1S78_RS07320	COG0488	(ABC) transporter
C1S78_RS07365	COG2205	protein histidine kinase activity
C1S78_RS07370	COG0745	RESPONSE REGULATOR receiver
C1S78_RS07380	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C1S78_RS07385	COG0183	Belongs to the thiolase family
C1S78_RS07390	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C1S78_RS07395	COG4569	acetaldehyde dehydrogenase (acetylating) activity
C1S78_RS07400	COG1309	transcriptional regulator
C1S78_RS07405	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C1S78_RS07410	COG2267	carboxylic ester hydrolase activity
C1S78_RS07425	COG1960	acyl-CoA dehydrogenase activity
C1S78_RS07455	COG1116	anion transmembrane transporter activity
C1S78_RS07460	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C1S78_RS07465	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C1S78_RS07470	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C1S78_RS07485	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C1S78_RS07490	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C1S78_RS07515	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C1S78_RS07560	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C1S78_RS07570	COG3757	hydrolase, family 25
C1S78_RS07575	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C1S78_RS07575	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
C1S78_RS07575	COG3321	synthase
C1S78_RS07585	COG1280	lysine exporter protein (LysE YggA)
C1S78_RS07605	COG0318	PFAM AMP-dependent synthetase and ligase
C1S78_RS07610	COG2188	Transcriptional regulator
C1S78_RS07660	COG0433	COG0433 Predicted ATPase
C1S78_RS07665	COG1028	Short-chain dehydrogenase reductase Sdr
C1S78_RS07685	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C1S78_RS07695	COG1960	acyl-CoA dehydrogenase activity
C1S78_RS07735	COG0508	dehydrogenase complex catalyzes the overall conversion of
C1S78_RS07785	COG2902	Dehydrogenase
C1S78_RS07790	COG0824	Thioesterase
C1S78_RS07850	COG0366	Alpha amylase catalytic
C1S78_RS07870	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
C1S78_RS07875	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C1S78_RS07890	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
C1S78_RS07915	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C1S78_RS07940	COG3239	Fatty acid desaturase
C1S78_RS07955	COG0544	peptidyl-prolyl cis-trans isomerase activity
C1S78_RS07960	COG0740	serine-type endopeptidase activity
C1S78_RS07965	COG0740	serine-type endopeptidase activity
C1S78_RS07995	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C1S78_RS08000	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C1S78_RS08010	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C1S78_RS08020	COG3118	belongs to the thioredoxin family
C1S78_RS08035	COG0674	pyruvate-flavodoxin oxidoreductase activity
C1S78_RS08035	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
C1S78_RS08040	COG1013	pyruvate-flavodoxin oxidoreductase activity
C1S78_RS08045	COG0746	molybdenum cofactor guanylyltransferase activity
C1S78_RS08050	COG1388	LysM domain
C1S78_RS08060	COG0823	Involved in the tonB-independent uptake of proteins
C1S78_RS08060	COG1506	peptidase
C1S78_RS08065	COG3268	Saccharopine dehydrogenase
C1S78_RS08075	COG0525	valine-tRNA ligase activity
C1S78_RS08080	COG0285	dihydrofolate synthase activity
C1S78_RS08095	COG1530	ribonuclease E activity
C1S78_RS08110	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C1S78_RS08115	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C1S78_RS08120	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C1S78_RS08125	COG2072	flavoprotein involved in K transport
C1S78_RS08155	COG2124	cytochrome p450
C1S78_RS08165	COG0066	3-isopropylmalate dehydratase activity
C1S78_RS08170	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C1S78_RS08190	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C1S78_RS08195	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C1S78_RS08200	COG0542	response to heat
C1S78_RS08210	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C1S78_RS08215	COG0799	negative regulation of ribosome biogenesis
C1S78_RS08220	COG0406	alpha-ribazole phosphatase activity
C1S78_RS08225	COG2755	lipolytic protein G-D-S-L family
C1S78_RS08240	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C1S78_RS08270	COG1596	polysaccharide export
C1S78_RS08270	COG1555	photosystem II stabilization
C1S78_RS08280	COG0174	glutamine synthetase
C1S78_RS08305	COG1305	Transglutaminase-like
C1S78_RS08310	COG0516	GMP reductase activity
C1S78_RS08310	COG0517	IMP dehydrogenase activity
C1S78_RS08335	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C1S78_RS08360	COG2020	methyltransferase activity
C1S78_RS08365	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C1S78_RS08380	COG3387	PFAM Glycoside hydrolase 15-related
C1S78_RS08390	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
C1S78_RS08395	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
C1S78_RS08400	COG4208	sulfate ABC transporter
C1S78_RS08410	COG1045	serine acetyltransferase
C1S78_RS08420	COG3158	transport of potassium into the cell
C1S78_RS08445	COG1132	(ABC) transporter
C1S78_RS08445	COG2375	cellular response to nickel ion
C1S78_RS08450	COG1132	(ABC) transporter
C1S78_RS08455	COG1169	isochorismate synthase
C1S78_RS08460	COG1846	Transcriptional regulator
C1S78_RS08480	COG1021	2,3-dihydroxybenzoate-AMP ligase
C1S78_RS08485	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
C1S78_RS08485	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C1S78_RS08505	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C1S78_RS08520	COG3251	PFAM MbtH domain protein
C1S78_RS08535	COG1420	regulation of RNA biosynthetic process
C1S78_RS08540	COG0484	heat shock protein binding
C1S78_RS08600	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C1S78_RS08610	COG0494	nUDIX hydrolase
C1S78_RS08625	COG0423	glycine-tRNA ligase activity
C1S78_RS08650	COG0232	Belongs to the dGTPase family. Type 2 subfamily
C1S78_RS08655	COG0358	DNA primase activity
C1S78_RS08730	COG1175	transmembrane transport
C1S78_RS08785	COG3706	GGDEF domain
C1S78_RS08835	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C1S78_RS08880	COG1063	alcohol dehydrogenase
C1S78_RS08885	COG2267	carboxylic ester hydrolase activity
C1S78_RS08915	COG0058	SHG alpha-glucan phosphorylase activity
C1S78_RS08920	COG1028	Short-chain dehydrogenase reductase Sdr
C1S78_RS08930	COG1802	Transcriptional regulator
C1S78_RS08935	COG3265	gluconokinase activity
C1S78_RS08950	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C1S78_RS08965	COG2252	PERMEase
C1S78_RS09015	COG1309	transcriptional regulator
C1S78_RS09045	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C1S78_RS09055	COG2814	Major facilitator Superfamily
C1S78_RS09065	COG1028	Short-chain dehydrogenase reductase Sdr
C1S78_RS09085	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C1S78_RS09095	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C1S78_RS09105	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
C1S78_RS09130	COG1285	pathogenesis
C1S78_RS09155	COG1028	Short-chain dehydrogenase reductase Sdr
C1S78_RS09165	COG1012	belongs to the aldehyde dehydrogenase family
C1S78_RS09180	COG1028	Short-chain dehydrogenase reductase Sdr
C1S78_RS09195	COG1012	belongs to the aldehyde dehydrogenase family
C1S78_RS09275	COG2197	response regulator
C1S78_RS09280	COG2197	response regulator
C1S78_RS09290	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C1S78_RS09315	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C1S78_RS09345	COG1396	sequence-specific DNA binding
C1S78_RS09350	COG0492	ferredoxin-NADP+ reductase activity
C1S78_RS09375	COG1024	Enoyl-CoA hydratase
C1S78_RS09410	COG4638	Rieske (2fe-2S)
C1S78_RS09415	COG0174	glutamine synthetase
C1S78_RS09420	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
C1S78_RS09430	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C1S78_RS09435	COG2259	Doxx family
C1S78_RS09450	COG0174	glutamine synthetase
C1S78_RS09475	COG0321	lipoyl(octanoyl) transferase activity
C1S78_RS09510	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C1S78_RS09515	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C1S78_RS09520	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
C1S78_RS09525	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
C1S78_RS09555	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C1S78_RS09590	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C1S78_RS09605	COG1845	cytochrome c oxidase, subunit III
C1S78_RS09635	COG0438	transferase activity, transferring glycosyl groups
C1S78_RS09670	COG5650	phosphatidylinositol metabolic process
C1S78_RS09705	COG2508	Transcriptional regulator
C1S78_RS09750	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
C1S78_RS09770	COG0142	geranyltranstransferase activity
C1S78_RS09795	COG0275	rRNA processing
C1S78_RS09805	COG0768	penicillin binding
C1S78_RS09835	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C1S78_RS09840	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C1S78_RS09845	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C1S78_RS09850	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C1S78_RS09865	COG1799	cell septum assembly
C1S78_RS09875	COG3599	regulation of cell shape
C1S78_RS09890	COG2186	Transcriptional regulator
C1S78_RS09900	COG0243	molybdopterin cofactor binding
C1S78_RS09970	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C1S78_RS10000	COG0167	dihydroorotate dehydrogenase activity
C1S78_RS10020	COG1968	undecaprenyl-diphosphatase activity
C1S78_RS10050	COG1218	3'(2'),5'-bisphosphate nucleotidase
C1S78_RS10060	COG2351	hydroxyisourate hydrolase activity
C1S78_RS10085	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C1S78_RS10090	COG0590	tRNA wobble adenosine to inosine editing
C1S78_RS10110	COG0215	cysteine-tRNA ligase activity
C1S78_RS10115	COG1028	Short-chain dehydrogenase reductase Sdr
C1S78_RS10130	COG0646	methionine synthase
C1S78_RS10130	COG1410	methionine synthase
C1S78_RS10135	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C1S78_RS10140	COG0477	Major facilitator Superfamily
C1S78_RS10155	COG0140	phosphoribosyl-ATP diphosphatase activity
C1S78_RS10160	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C1S78_RS10170	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C1S78_RS10175	COG0655	NAD(P)H dehydrogenase (quinone) activity
C1S78_RS10195	COG1216	Glycosyl transferase, family 2
C1S78_RS10215	COG0477	Major facilitator Superfamily
C1S78_RS10220	COG1733	regulation of RNA biosynthetic process
C1S78_RS10265	COG4122	O-methyltransferase activity
C1S78_RS10275	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
C1S78_RS10280	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
C1S78_RS10290	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C1S78_RS10295	COG2957	Belongs to the agmatine deiminase family
C1S78_RS10315	COG0346	lactoylglutathione lyase activity
C1S78_RS10320	COG2902	Dehydrogenase
C1S78_RS10330	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C1S78_RS10350	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C1S78_RS10370	COG1012	belongs to the aldehyde dehydrogenase family
C1S78_RS10390	COG0446	pyridine nucleotide-disulphide oxidoreductase
C1S78_RS10395	COG1937	Protein conserved in bacteria
C1S78_RS10400	COG2140	Oxalate decarboxylase
C1S78_RS10430	COG2378	regulation of single-species biofilm formation
C1S78_RS10450	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C1S78_RS10470	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C1S78_RS10495	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C1S78_RS10525	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C1S78_RS10550	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C1S78_RS10580	COG0440	acetolactate synthase activity
C1S78_RS10595	COG0655	NAD(P)H dehydrogenase (quinone) activity
C1S78_RS10670	COG2271	Major facilitator Superfamily
C1S78_RS10680	COG0179	Fumarylacetoacetate (FAA) hydrolase
C1S78_RS10685	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C1S78_RS10715	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C1S78_RS10730	COG0406	alpha-ribazole phosphatase activity
C1S78_RS10730	COG0494	nUDIX hydrolase
C1S78_RS10735	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
C1S78_RS10740	COG1920	GTP binding
C1S78_RS10750	COG0626	cystathionine gamma-synthase activity
C1S78_RS10755	COG1181	Belongs to the D-alanine--D-alanine ligase family
C1S78_RS10780	COG1461	Dihydroxyacetone kinase
C1S78_RS10785	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C1S78_RS10800	COG0656	L-ascorbic acid biosynthetic process
C1S78_RS10805	COG0656	L-ascorbic acid biosynthetic process
C1S78_RS10810	COG0657	acetylesterase activity
C1S78_RS10830	COG0742	ribosomal rna small subunit methyltransferase
C1S78_RS10835	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C1S78_RS10840	COG3599	regulation of cell shape
C1S78_RS10880	COG1254	Belongs to the acylphosphatase family
C1S78_RS10905	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
C1S78_RS10910	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C1S78_RS10925	COG1686	Belongs to the peptidase S11 family
C1S78_RS10930	COG1686	Belongs to the peptidase S11 family
C1S78_RS11005	COG2190	(PTS) system
C1S78_RS11005	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C1S78_RS11005	COG1263	PTS System
C1S78_RS11010	COG2190	(PTS) system
C1S78_RS11020	COG1053	succinate dehydrogenase
C1S78_RS11035	COG1028	Short-chain dehydrogenase reductase Sdr
C1S78_RS11040	COG1028	Short-chain dehydrogenase reductase Sdr
C1S78_RS11070	COG0657	acetylesterase activity
C1S78_RS11075	COG1414	Transcriptional regulator
C1S78_RS11085	COG0346	lactoylglutathione lyase activity
C1S78_RS11095	COG2072	flavoprotein involved in K transport
C1S78_RS11100	COG1028	Short-chain dehydrogenase reductase Sdr
C1S78_RS11120	COG2267	carboxylic ester hydrolase activity
C1S78_RS11125	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C1S78_RS11135	COG0028	Belongs to the TPP enzyme family
C1S78_RS11145	COG0792	nuclease activity
C1S78_RS11160	COG2124	cytochrome p450
C1S78_RS11180	COG0318	PFAM AMP-dependent synthetase and ligase
C1S78_RS11225	COG0052	Belongs to the universal ribosomal protein uS2 family
C1S78_RS11230	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C1S78_RS11260	COG0154	amidase activity
C1S78_RS11270	COG0754	glutathionylspermidine amidase activity
C1S78_RS11290	COG0528	UMP kinase activity
C1S78_RS11295	COG0233	cytoplasmic translational termination
C1S78_RS11300	COG0575	Belongs to the CDS family
C1S78_RS11310	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C1S78_RS11325	COG1309	transcriptional regulator
C1S78_RS11360	COG0659	secondary active sulfate transmembrane transporter activity
C1S78_RS11405	COG1028	Short-chain dehydrogenase reductase Sdr
C1S78_RS11415	COG0657	acetylesterase activity
C1S78_RS11450	COG0750	zinc metalloprotease
C1S78_RS11460	COG0454	-acetyltransferase
C1S78_RS11460	COG0456	acetyltransferase
C1S78_RS11480	COG1492	cobalamin metabolic process
C1S78_RS11495	COG0642	Histidine kinase
C1S78_RS11500	COG0745	RESPONSE REGULATOR receiver
C1S78_RS11520	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C1S78_RS11525	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
C1S78_RS11565	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C1S78_RS11565	COG1648	precorrin-2 dehydrogenase activity
C1S78_RS11575	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
C1S78_RS11605	COG0779	Required for maturation of 30S ribosomal subunits
C1S78_RS11610	COG0195	Participates in both transcription termination and antitermination
C1S78_RS11630	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
C1S78_RS11640	COG1024	Enoyl-CoA hydratase
C1S78_RS11680	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C1S78_RS11685	COG2977	Belongs to the P-Pant transferase superfamily
C1S78_RS11700	COG0183	Belongs to the thiolase family
C1S78_RS11715	COG1028	Short-chain dehydrogenase reductase Sdr
C1S78_RS11720	COG1960	acyl-CoA dehydrogenase activity
C1S78_RS11725	COG0657	acetylesterase activity
C1S78_RS11730	COG0318	PFAM AMP-dependent synthetase and ligase
C1S78_RS11740	COG0667	Aldo Keto reductase
C1S78_RS11745	COG1309	transcriptional regulator
C1S78_RS11760	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C1S78_RS11765	COG1185	polyribonucleotide nucleotidyltransferase activity
C1S78_RS11780	COG0686	Belongs to the AlaDH PNT family
C1S78_RS11790	COG1309	transcriptional regulator
C1S78_RS11805	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C1S78_RS11820	COG0202	RNA polymerase activity
C1S78_RS11830	COG2301	Belongs to the HpcH HpaI aldolase family
C1S78_RS11840	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
C1S78_RS11850	COG1305	Transglutaminase-like
C1S78_RS11855	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C1S78_RS11860	COG0187	DNA topoisomerase II activity
C1S78_RS11865	COG3214	Protein conserved in bacteria
C1S78_RS11880	COG0531	amino acid
C1S78_RS11885	COG2267	carboxylic ester hydrolase activity
C1S78_RS11895	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C1S78_RS11900	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
C1S78_RS11905	COG1309	transcriptional regulator
C1S78_RS11915	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C1S78_RS11940	COG1674	ftsk spoiiie
C1S78_RS11950	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C1S78_RS11960	COG1396	sequence-specific DNA binding
C1S78_RS11965	COG1842	Phage shock protein A
C1S78_RS11980	COG4308	Limonene-1,2-epoxide hydrolase catalytic domain
C1S78_RS12000	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C1S78_RS12005	COG2137	regulation of response to DNA damage stimulus
C1S78_RS12015	COG1028	Short-chain dehydrogenase reductase Sdr
C1S78_RS12025	COG0765	amino acid transport
C1S78_RS12030	COG0765	amino acid transport
C1S78_RS12035	COG1126	abc transporter atp-binding protein
C1S78_RS12040	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C1S78_RS12050	COG1196	nuclear chromosome segregation
C1S78_RS12065	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C1S78_RS12070	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C1S78_RS12075	COG5651	PPE family
C1S78_RS12075	COG3391	amine dehydrogenase activity
C1S78_RS12080	COG0513	Belongs to the DEAD box helicase family
C1S78_RS12085	COG1960	acyl-CoA dehydrogenase activity
C1S78_RS12090	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
C1S78_RS12090	COG5479	isomerase activity
C1S78_RS12095	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C1S78_RS12100	COG1388	LysM domain
C1S78_RS12170	COG0406	alpha-ribazole phosphatase activity
C1S78_RS12175	COG0406	alpha-ribazole phosphatase activity
C1S78_RS12200	COG0483	inositol monophosphate 1-phosphatase activity
C1S78_RS12250	COG0569	domain protein
C1S78_RS12255	COG0531	amino acid
C1S78_RS12260	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C1S78_RS12265	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C1S78_RS12270	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C1S78_RS12305	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C1S78_RS12315	COG3253	May function as heme-dependent peroxidase
C1S78_RS12335	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C1S78_RS12390	COG1309	transcriptional regulator
C1S78_RS12435	COG5651	PPE family
C1S78_RS12440	COG1252	NADH dehydrogenase
C1S78_RS12465	COG4762	Protein conserved in bacteria
C1S78_RS12485	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C1S78_RS12490	COG1560	Kdo2-lipid A biosynthetic process
C1S78_RS12495	COG0438	transferase activity, transferring glycosyl groups
C1S78_RS12510	COG1946	Acyl-CoA thioesterase
C1S78_RS12515	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
C1S78_RS12525	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C1S78_RS12535	COG0217	transcriptional regulatory protein
C1S78_RS12565	COG2255	four-way junction helicase activity
C1S78_RS12595	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C1S78_RS12600	COG0747	negative chemotaxis
C1S78_RS12610	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C1S78_RS12675	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C1S78_RS12680	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C1S78_RS12690	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C1S78_RS12695	COG0124	histidyl-tRNA synthetase
C1S78_RS12700	COG3038	cytochrome b561
C1S78_RS12705	COG0753	catalase activity
C1S78_RS12710	COG1490	D-aminoacyl-tRNA deacylase activity
C1S78_RS12730	COG0657	acetylesterase activity
C1S78_RS12755	COG0028	Belongs to the TPP enzyme family
C1S78_RS12770	COG2890	protein-(glutamine-N5) methyltransferase activity
C1S78_RS12830	COG0783	Belongs to the Dps family
C1S78_RS12835	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C1S78_RS12840	COG3707	response regulator
C1S78_RS12870	COG2072	flavoprotein involved in K transport
C1S78_RS12890	COG2272	Belongs to the type-B carboxylesterase lipase family
C1S78_RS12925	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C1S78_RS12930	COG2072	flavoprotein involved in K transport
C1S78_RS12940	COG0183	Belongs to the thiolase family
C1S78_RS12945	COG1733	regulation of RNA biosynthetic process
C1S78_RS12995	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C1S78_RS13000	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C1S78_RS13005	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C1S78_RS13010	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C1S78_RS13035	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C1S78_RS13050	COG0006	proline dipeptidase activity
C1S78_RS13055	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C1S78_RS13060	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C1S78_RS13070	COG0243	molybdopterin cofactor binding
C1S78_RS13075	COG2188	Transcriptional regulator
C1S78_RS13105	COG0154	amidase activity
C1S78_RS13140	COG0477	Major facilitator Superfamily
C1S78_RS13145	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
C1S78_RS13165	COG0505	Belongs to the CarA family
C1S78_RS13170	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C1S78_RS13175	COG0284	orotidine-5'-phosphate decarboxylase activity
C1S78_RS13205	COG1758	RNA polymerase activity
C1S78_RS13225	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C1S78_RS13235	COG2072	flavoprotein involved in K transport
C1S78_RS13245	COG0657	acetylesterase activity
C1S78_RS13255	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C1S78_RS13300	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C1S78_RS13300	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C1S78_RS13325	COG1365	unkown
C1S78_RS13330	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C1S78_RS13335	COG0322	excinuclease ABC activity
C1S78_RS13340	COG1660	Displays ATPase and GTPase activities
C1S78_RS13350	COG1481	regulation of sporulation
C1S78_RS13355	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C1S78_RS13360	COG0126	phosphoglycerate kinase activity
C1S78_RS13365	COG0149	triose-phosphate isomerase activity
C1S78_RS13390	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
C1S78_RS13445	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C1S78_RS13455	COG0109	protoheme IX farnesyltransferase activity
C1S78_RS13485	COG1131	(ABC) transporter
C1S78_RS13510	COG0396	ATPase activity
C1S78_RS13525	COG2151	metal-sulfur cluster biosynthetic enzyme
C1S78_RS13545	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C1S78_RS13555	COG0488	(ABC) transporter
C1S78_RS13570	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C1S78_RS13575	COG0531	amino acid
C1S78_RS13580	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C1S78_RS13585	COG1396	sequence-specific DNA binding
C1S78_RS13595	COG1309	transcriptional regulator
C1S78_RS13600	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C1S78_RS13610	COG0791	NLP P60 protein
C1S78_RS13610	COG3883	PFAM NLP P60 protein
C1S78_RS13620	COG0714	Associated with various cellular activities
C1S78_RS13630	COG1028	Short-chain dehydrogenase reductase Sdr
C1S78_RS13635	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C1S78_RS13640	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C1S78_RS13685	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C1S78_RS13690	COG3321	synthase
C1S78_RS13690	COG1028	Short-chain dehydrogenase reductase Sdr
C1S78_RS13690	COG0604	alcohol dehydrogenase
C1S78_RS13745	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C1S78_RS13750	COG1051	belongs to the nudix hydrolase family
C1S78_RS13755	COG1051	belongs to the nudix hydrolase family
C1S78_RS13765	COG2501	S4 domain
C1S78_RS13775	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C1S78_RS13775	COG2755	lipolytic protein G-D-S-L family
C1S78_RS13780	COG0252	asparaginase activity
C1S78_RS13785	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C1S78_RS13815	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
C1S78_RS13860	COG2272	Belongs to the type-B carboxylesterase lipase family
C1S78_RS13865	COG3415	Transposase
C1S78_RS13865	COG2801	Transposase and inactivated derivatives
C1S78_RS13900	COG0596	Alpha beta hydrolase
C1S78_RS13905	COG1556	Lactate utilization protein
C1S78_RS13910	COG1139	Iron-sulfur cluster binding protein
C1S78_RS13915	COG0247	lactate metabolic process
C1S78_RS13920	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C1S78_RS13945	COG1063	alcohol dehydrogenase
C1S78_RS13985	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
C1S78_RS13990	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C1S78_RS13995	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C1S78_RS14000	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C1S78_RS14005	COG0318	PFAM AMP-dependent synthetase and ligase
C1S78_RS14010	COG1309	transcriptional regulator
C1S78_RS14020	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C1S78_RS14025	COG3119	arylsulfatase activity
C1S78_RS14035	COG2130	NADP-dependent
C1S78_RS14075	COG0531	amino acid
C1S78_RS14085	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C1S78_RS14085	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C1S78_RS14090	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C1S78_RS14095	COG0509	glycine decarboxylation via glycine cleavage system
C1S78_RS14110	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C1S78_RS14115	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C1S78_RS14125	COG1028	Short-chain dehydrogenase reductase Sdr
C1S78_RS14145	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C1S78_RS14185	COG1309	transcriptional regulator
C1S78_RS14190	COG1063	alcohol dehydrogenase
C1S78_RS14235	COG2814	Major facilitator Superfamily
C1S78_RS14255	COG1481	regulation of sporulation
C1S78_RS14265	COG1595	DNA-templated transcription, initiation
C1S78_RS14270	COG1302	Protein conserved in bacteria
C1S78_RS14300	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C1S78_RS14335	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C1S78_RS14395	COG0736	holo-[acyl-carrier-protein] synthase activity
C1S78_RS14410	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C1S78_RS14420	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C1S78_RS14490	COG0789	Transcriptional regulator
C1S78_RS14500	COG4974	Belongs to the 'phage' integrase family
C1S78_RS14580	COG1028	Short-chain dehydrogenase reductase Sdr
C1S78_RS14585	COG0778	Nitroreductase
C1S78_RS14590	COG3852	Histidine kinase
C1S78_RS14605	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C1S78_RS14610	COG1309	transcriptional regulator
C1S78_RS14625	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C1S78_RS14640	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C1S78_RS14645	COG2353	YceI-like domain
C1S78_RS14720	COG0693	protein deglycase activity
C1S78_RS14725	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C1S78_RS14730	COG1126	abc transporter atp-binding protein
C1S78_RS14735	COG0765	amino acid transport
C1S78_RS14745	COG2199	diguanylate cyclase activity
C1S78_RS14745	COG2203	Gaf domain
C1S78_RS14760	COG2814	Major facilitator Superfamily
C1S78_RS14810	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C1S78_RS14835	COG3185	4-Hydroxyphenylpyruvate dioxygenase
C1S78_RS14840	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
C1S78_RS14870	COG2365	Tyrosine phosphatase family
C1S78_RS14890	COG0071	Belongs to the small heat shock protein (HSP20) family
C1S78_RS14930	COG2318	DinB family
C1S78_RS14940	COG4941	Belongs to the sigma-70 factor family
C1S78_RS14970	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C1S78_RS15015	COG0531	amino acid
C1S78_RS15035	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C1S78_RS15045	COG4221	oxidoreductase activity
C1S78_RS15055	COG0714	Associated with various cellular activities
C1S78_RS15080	COG1335	isochorismatase
C1S78_RS15085	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C1S78_RS15190	COG2814	Major facilitator Superfamily
C1S78_RS15195	COG0583	DNA-binding transcription factor activity
C1S78_RS15215	COG2755	lipolytic protein G-D-S-L family
C1S78_RS15220	COG2755	lipolytic protein G-D-S-L family
C1S78_RS15220	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C1S78_RS15240	COG3022	response to hydroperoxide
C1S78_RS15270	COG3250	beta-galactosidase activity
C1S78_RS15305	COG0243	molybdopterin cofactor binding
C1S78_RS15310	COG3707	response regulator
C1S78_RS15340	COG1376	ErfK ybiS ycfS ynhG family protein
C1S78_RS15375	COG0412	Dienelactone hydrolase
C1S78_RS15395	COG2193	ferroxidase activity
C1S78_RS15480	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C1S78_RS15535	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C1S78_RS15540	COG1252	NADH dehydrogenase
C1S78_RS15545	COG0829	nickel cation binding
C1S78_RS15550	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
C1S78_RS15555	COG0830	nickel cation binding
C1S78_RS15595	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
C1S78_RS15605	COG1253	flavin adenine dinucleotide binding
C1S78_RS15610	COG1253	flavin adenine dinucleotide binding
C1S78_RS15640	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C1S78_RS15640	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C1S78_RS15660	COG1716	ATPase activity
C1S78_RS15665	COG0509	glycine decarboxylation via glycine cleavage system
C1S78_RS15690	COG0653	protein targeting
C1S78_RS15700	COG3976	FMN-binding domain protein
C1S78_RS15700	COG1053	succinate dehydrogenase
C1S78_RS15705	COG0640	Transcriptional regulator
C1S78_RS15825	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C1S78_RS15845	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
C1S78_RS15865	COG1017	nitric oxide dioxygenase activity
C1S78_RS15865	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C1S78_RS15900	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C1S78_RS15900	COG0189	ligase activity
C1S78_RS15905	COG0367	asparagine synthase
C1S78_RS15915	COG2197	response regulator
C1S78_RS15930	COG4585	Histidine kinase
C1S78_RS15935	COG2201	protein-glutamate methylesterase activity
C1S78_RS15965	COG2272	Belongs to the type-B carboxylesterase lipase family
C1S78_RS15975	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C1S78_RS15985	COG0277	FAD linked oxidase domain protein
C1S78_RS16005	COG0038	chloride channel
C1S78_RS16010	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C1S78_RS16025	COG1012	belongs to the aldehyde dehydrogenase family
C1S78_RS16035	COG3268	Saccharopine dehydrogenase
C1S78_RS16060	COG0300	oxidoreductase activity
C1S78_RS16165	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C1S78_RS16180	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C1S78_RS16190	COG1024	Enoyl-CoA hydratase
C1S78_RS16205	COG0702	epimerase
C1S78_RS16230	COG1611	Belongs to the LOG family
C1S78_RS16235	COG2197	response regulator
C1S78_RS16250	COG1752	Esterase of the alpha-beta hydrolase superfamily
C1S78_RS16315	COG1160	GTP binding
C1S78_RS16330	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C1S78_RS16335	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
C1S78_RS16360	COG0494	nUDIX hydrolase
C1S78_RS16365	COG0504	CTP synthase activity
C1S78_RS16395	COG0497	DNA recombination
C1S78_RS16415	COG0647	UMP catabolic process
C1S78_RS16455	COG1131	(ABC) transporter
C1S78_RS16470	COG2835	tetraacyldisaccharide 4'-kinase activity
C1S78_RS16485	COG0488	(ABC) transporter
C1S78_RS16500	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C1S78_RS16510	COG0165	Argininosuccinate lyase
C1S78_RS16515	COG0137	argininosuccinate synthase activity
C1S78_RS16520	COG1438	arginine binding
C1S78_RS16525	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C1S78_RS16530	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C1S78_RS16535	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C1S78_RS16540	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
C1S78_RS16560	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C1S78_RS16565	COG0604	alcohol dehydrogenase
C1S78_RS16570	COG0596	Alpha beta hydrolase
C1S78_RS16580	COG0508	dehydrogenase complex catalyzes the overall conversion of
C1S78_RS16580	COG0596	Alpha beta hydrolase
C1S78_RS16600	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C1S78_RS16600	COG0072	phenylalanine-tRNA ligase activity
C1S78_RS16605	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C1S78_RS16620	COG1960	acyl-CoA dehydrogenase activity
C1S78_RS16630	COG0667	Aldo Keto reductase
C1S78_RS16635	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C1S78_RS16645	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C1S78_RS16650	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C1S78_RS16665	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
C1S78_RS16665	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C1S78_RS16700	COG1842	Phage shock protein A
C1S78_RS16715	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C1S78_RS16755	COG1285	pathogenesis
C1S78_RS16760	COG0657	acetylesterase activity
C1S78_RS16785	COG0237	dephospho-CoA kinase activity
C1S78_RS16785	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
C1S78_RS16790	COG0539	negative regulation of cytoplasmic translation
C1S78_RS16920	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1S78_RS16930	COG1271	oxidase subunit
C1S78_RS16935	COG1294	oxidase, subunit
C1S78_RS16940	COG4988	ABC transporter
C1S78_RS16945	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
C1S78_RS16990	COG0134	indole-3-glycerol-phosphate synthase activity
C1S78_RS17000	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C1S78_RS17010	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C1S78_RS17020	COG1119	ATPase activity
C1S78_RS17040	COG1028	Short-chain dehydrogenase reductase Sdr
C1S78_RS17050	COG1984	allophanate hydrolase subunit 2
C1S78_RS17075	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C1S78_RS17080	COG0107	imidazoleglycerol-phosphate synthase activity
C1S78_RS17085	COG0483	inositol monophosphate 1-phosphatase activity
C1S78_RS17090	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C1S78_RS17095	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C1S78_RS17100	COG0131	Imidazoleglycerol-phosphate dehydratase
C1S78_RS17105	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C1S78_RS17140	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C1S78_RS17185	COG1309	transcriptional regulator
C1S78_RS17200	COG0156	8-amino-7-oxononanoate synthase activity
C1S78_RS17270	COG0463	Glycosyl transferase, family 2
C1S78_RS17275	COG0815	Transfers the fatty acyl group on membrane lipoproteins
C1S78_RS17280	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
C1S78_RS17320	COG2203	Gaf domain
C1S78_RS17320	COG3706	GGDEF domain
C1S78_RS17320	COG5001	Diguanylate cyclase
C1S78_RS17320	COG4251	negative regulation of phosphorylation
C1S78_RS17390	COG0318	PFAM AMP-dependent synthetase and ligase
C1S78_RS17415	COG0482	sulfurtransferase activity
C1S78_RS17445	COG2072	flavoprotein involved in K transport
C1S78_RS17470	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C1S78_RS17485	COG0778	Nitroreductase
C1S78_RS17490	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C1S78_RS17505	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C1S78_RS17515	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C1S78_RS17530	COG2132	Multicopper oxidase
C1S78_RS17535	COG0110	maltose O-acetyltransferase activity
C1S78_RS17540	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C1S78_RS17570	COG1119	ATPase activity
C1S78_RS17575	COG2364	Membrane
C1S78_RS17585	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C1S78_RS17620	COG4266	Belongs to the allantoicase family
C1S78_RS17630	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C1S78_RS17645	COG1335	isochorismatase
C1S78_RS17650	COG0601	transmembrane transport
C1S78_RS17655	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1S78_RS17665	COG1309	transcriptional regulator
C1S78_RS17675	COG1064	alcohol dehydrogenase
C1S78_RS17700	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C1S78_RS17710	COG1309	transcriptional regulator
C1S78_RS17720	COG5651	PPE family
C1S78_RS17720	COG3391	amine dehydrogenase activity
C1S78_RS17725	COG1309	transcriptional regulator
C1S78_RS17775	COG2851	Citrate transporter
C1S78_RS17780	COG3290	protein histidine kinase activity
C1S78_RS17785	COG4565	transcriptional regulatory protein
C1S78_RS17795	COG0402	S-adenosylhomocysteine deaminase activity
C1S78_RS17810	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C1S78_RS17815	COG3491	Belongs to the iron ascorbate-dependent oxidoreductase family
C1S78_RS17830	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C1S78_RS17835	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C1S78_RS17875	COG2508	Transcriptional regulator
C1S78_RS17920	COG2184	nucleotidyltransferase activity
C1S78_RS17955	COG1966	Carbon starvation protein
C1S78_RS17990	COG0477	Major facilitator Superfamily
C1S78_RS17995	COG1802	Transcriptional regulator
C1S78_RS18000	COG1960	acyl-CoA dehydrogenase activity
C1S78_RS18005	COG0183	Belongs to the thiolase family
C1S78_RS18015	COG1960	acyl-CoA dehydrogenase activity
C1S78_RS18050	COG1960	acyl-CoA dehydrogenase activity
C1S78_RS18055	COG1960	acyl-CoA dehydrogenase activity
C1S78_RS18085	COG3321	synthase
C1S78_RS18085	COG1028	Short-chain dehydrogenase reductase Sdr
C1S78_RS18085	COG0604	alcohol dehydrogenase
C1S78_RS18100	COG0745	RESPONSE REGULATOR receiver
C1S78_RS18105	COG2205	protein histidine kinase activity
C1S78_RS18110	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C1S78_RS18115	COG0415	Belongs to the DNA photolyase family
C1S78_RS18145	COG1960	acyl-CoA dehydrogenase activity
C1S78_RS18155	COG5002	protein histidine kinase activity
C1S78_RS18165	COG0318	PFAM AMP-dependent synthetase and ligase
C1S78_RS18175	COG0318	PFAM AMP-dependent synthetase and ligase
C1S78_RS18180	COG1024	Enoyl-CoA hydratase
C1S78_RS18185	COG0318	PFAM AMP-dependent synthetase and ligase
C1S78_RS18195	COG0318	PFAM AMP-dependent synthetase and ligase
C1S78_RS18200	COG2188	Transcriptional regulator
C1S78_RS18205	COG3386	PFAM SMP-30 Gluconolaconase
C1S78_RS18210	COG1028	Short-chain dehydrogenase reductase Sdr
C1S78_RS18220	COG2072	flavoprotein involved in K transport
C1S78_RS18230	COG1028	Short-chain dehydrogenase reductase Sdr
C1S78_RS18235	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C1S78_RS18240	COG1960	acyl-CoA dehydrogenase activity
C1S78_RS18250	COG1960	acyl-CoA dehydrogenase activity
C1S78_RS18255	COG1960	acyl-CoA dehydrogenase activity
C1S78_RS18290	COG1028	Short-chain dehydrogenase reductase Sdr
C1S78_RS18310	COG0789	Transcriptional regulator
C1S78_RS18315	COG1960	acyl-CoA dehydrogenase activity
C1S78_RS18320	COG1960	acyl-CoA dehydrogenase activity
C1S78_RS18350	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
C1S78_RS18370	COG2084	Dehydrogenase
C1S78_RS18375	COG2084	Dehydrogenase
C1S78_RS18380	COG2124	cytochrome p450
C1S78_RS18445	COG1228	amidohydrolase
C1S78_RS18455	COG4638	Rieske (2fe-2S)
C1S78_RS18460	COG1309	transcriptional regulator
C1S78_RS18475	COG0714	Associated with various cellular activities
C1S78_RS18500	COG1309	transcriptional regulator
C1S78_RS18505	COG1960	acyl-CoA dehydrogenase activity
C1S78_RS18510	COG1024	Enoyl-CoA hydratase
C1S78_RS18515	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C1S78_RS18520	COG1028	Short-chain dehydrogenase reductase Sdr
C1S78_RS18540	COG4638	Rieske (2fe-2S)
C1S78_RS18550	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
C1S78_RS18560	COG1960	acyl-CoA dehydrogenase activity
C1S78_RS18565	COG1960	acyl-CoA dehydrogenase activity
C1S78_RS18570	COG1960	acyl-CoA dehydrogenase activity
C1S78_RS18580	COG1946	Acyl-CoA thioesterase
C1S78_RS18585	COG1028	Short-chain dehydrogenase reductase Sdr
C1S78_RS18645	COG1960	acyl-CoA dehydrogenase activity
C1S78_RS18650	COG1960	acyl-CoA dehydrogenase activity
C1S78_RS18655	COG0318	PFAM AMP-dependent synthetase and ligase
C1S78_RS18660	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C1S78_RS18665	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C1S78_RS18675	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C1S78_RS18680	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C1S78_RS18680	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C1S78_RS18695	COG1024	Enoyl-CoA hydratase
C1S78_RS18735	COG1946	Acyl-CoA thioesterase
C1S78_RS18780	COG0477	Major facilitator Superfamily
C1S78_RS18810	COG0318	PFAM AMP-dependent synthetase and ligase
C1S78_RS18905	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C1S78_RS18915	COG2884	Cell division ATP-binding protein ftsE
C1S78_RS18925	COG0668	transmembrane transport
C1S78_RS18930	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C1S78_RS18950	COG0483	inositol monophosphate 1-phosphatase activity
C1S78_RS18960	COG1960	acyl-CoA dehydrogenase activity
C1S78_RS18965	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
C1S78_RS18975	COG1960	acyl-CoA dehydrogenase activity
C1S78_RS18995	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C1S78_RS19000	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C1S78_RS19030	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C1S78_RS19035	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C1S78_RS19040	COG0649	NAD binding
C1S78_RS19055	COG1034	ATP synthesis coupled electron transport
C1S78_RS19065	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C1S78_RS19075	COG0713	ATP synthesis coupled electron transport
C1S78_RS19125	COG1024	Enoyl-CoA hydratase
C1S78_RS19130	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C1S78_RS19135	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C1S78_RS19160	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C1S78_RS19190	COG0657	acetylesterase activity
C1S78_RS19195	COG1414	Transcriptional regulator
C1S78_RS19235	COG0346	lactoylglutathione lyase activity
C1S78_RS19250	COG1414	Transcriptional regulator
C1S78_RS19270	COG2072	flavoprotein involved in K transport
C1S78_RS19275	COG0318	PFAM AMP-dependent synthetase and ligase
C1S78_RS19280	COG1063	alcohol dehydrogenase
C1S78_RS19290	COG1024	Enoyl-CoA hydratase
C1S78_RS19295	COG1960	acyl-CoA dehydrogenase activity
C1S78_RS19315	COG0657	acetylesterase activity
C1S78_RS19350	COG1053	succinate dehydrogenase
C1S78_RS19485	COG0183	Belongs to the thiolase family
C1S78_RS19490	COG1960	acyl-CoA dehydrogenase activity
C1S78_RS19495	COG1960	acyl-CoA dehydrogenase activity
C1S78_RS19500	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C1S78_RS19505	COG0583	DNA-binding transcription factor activity
C1S78_RS19515	COG2072	flavoprotein involved in K transport
C1S78_RS19520	COG0596	Alpha beta hydrolase
C1S78_RS19545	COG1960	acyl-CoA dehydrogenase activity
C1S78_RS19550	COG1012	belongs to the aldehyde dehydrogenase family
C1S78_RS19580	COG1113	amino acid transport
C1S78_RS19605	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C1S78_RS19620	COG1116	anion transmembrane transporter activity
C1S78_RS19635	COG0583	DNA-binding transcription factor activity
C1S78_RS19640	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C1S78_RS19645	COG0252	asparaginase activity
C1S78_RS19660	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C1S78_RS19735	COG0402	S-adenosylhomocysteine deaminase activity
C1S78_RS19825	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C1S78_RS19830	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C1S78_RS19835	COG1309	transcriptional regulator
C1S78_RS19850	COG1959	2 iron, 2 sulfur cluster binding
C1S78_RS19865	COG1028	Short-chain dehydrogenase reductase Sdr
C1S78_RS19890	COG1053	succinate dehydrogenase
C1S78_RS19890	COG3976	FMN-binding domain protein
C1S78_RS19895	COG3384	dioxygenase
C1S78_RS19920	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C1S78_RS19940	COG0714	Associated with various cellular activities
C1S78_RS19955	COG0747	negative chemotaxis
C1S78_RS19960	COG0601	transmembrane transport
C1S78_RS19965	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1S78_RS19990	COG3480	Lon protease (S16) C-terminal proteolytic domain
C1S78_RS20005	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C1S78_RS20035	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C1S78_RS20055	COG0596	Alpha beta hydrolase
C1S78_RS20060	COG3695	enzyme binding
C1S78_RS20115	COG0513	Belongs to the DEAD box helicase family
C1S78_RS20130	COG0406	alpha-ribazole phosphatase activity
C1S78_RS20145	COG5002	protein histidine kinase activity
C1S78_RS20160	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C1S78_RS20165	COG3012	SEC-C Motif Domain Protein
C1S78_RS20170	COG1597	lipid kinase activity
C1S78_RS20185	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
C1S78_RS20190	COG5662	AntiSigma factor
C1S78_RS20195	COG1595	DNA-templated transcription, initiation
C1S78_RS20200	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C1S78_RS20205	COG1028	Short-chain dehydrogenase reductase Sdr
C1S78_RS20225	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C1S78_RS20230	COG2890	protein-(glutamine-N5) methyltransferase activity
C1S78_RS20235	COG2135	peptidase activity
C1S78_RS20240	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C1S78_RS20245	COG1162	GTPase activity
C1S78_RS20270	COG2326	polyphosphate kinase activity
C1S78_RS20285	COG0653	protein targeting
C1S78_RS20290	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C1S78_RS20300	COG0723	plastoquinol--plastocyanin reductase activity
C1S78_RS20315	COG5401	PFAM Sporulation and spore germination
C1S78_RS20320	COG5002	protein histidine kinase activity
C1S78_RS20325	COG0745	RESPONSE REGULATOR receiver
C1S78_RS20335	COG1301	dicarboxylic acid transport
C1S78_RS20385	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
C1S78_RS20405	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C1S78_RS20415	COG1482	cell wall glycoprotein biosynthetic process
C1S78_RS20425	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C1S78_RS20450	COG0778	Nitroreductase
C1S78_RS20450	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
C1S78_RS20460	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C1S78_RS20470	COG1316	TRANSCRIPTIONal
C1S78_RS20490	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
C1S78_RS20560	COG0489	protein tyrosine kinase activity
C1S78_RS20560	COG3206	protein involved in exopolysaccharide biosynthesis
C1S78_RS20600	COG0438	transferase activity, transferring glycosyl groups
C1S78_RS20610	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C1S78_RS20635	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C1S78_RS20640	COG1595	DNA-templated transcription, initiation
C1S78_RS20670	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C1S78_RS20675	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
C1S78_RS20695	COG4770	biotin carboxylase activity
C1S78_RS20710	COG0640	Transcriptional regulator
C1S78_RS20715	COG3832	glyoxalase III activity
C1S78_RS20740	COG1522	sequence-specific DNA binding
C1S78_RS20750	COG1012	belongs to the aldehyde dehydrogenase family
C1S78_RS20760	COG1201	RNA secondary structure unwinding
C1S78_RS20765	COG0069	glutamate synthase activity
C1S78_RS20765	COG0070	glutamate synthase
C1S78_RS20765	COG0067	glutamate synthase
C1S78_RS20770	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C1S78_RS20780	COG0183	Belongs to the thiolase family
C1S78_RS20785	COG0789	Transcriptional regulator
C1S78_RS20790	COG2070	2-Nitropropane dioxygenase
C1S78_RS20810	COG1309	transcriptional regulator
C1S78_RS20815	COG1024	Enoyl-CoA hydratase
C1S78_RS20840	COG0523	cobalamin synthesis protein
C1S78_RS20845	COG2353	YceI-like domain
C1S78_RS20865	COG1028	Short-chain dehydrogenase reductase Sdr
C1S78_RS20870	COG0564	pseudouridine synthase activity
C1S78_RS20895	COG1473	amidohydrolase
C1S78_RS20895	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
C1S78_RS20910	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C1S78_RS20925	COG0791	NLP P60 protein
C1S78_RS20985	COG2009	succinate dehydrogenase
C1S78_RS20995	COG1053	succinate dehydrogenase
C1S78_RS21000	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C1S78_RS21025	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C1S78_RS21035	COG0384	phenazine biosynthesis protein PhzF
C1S78_RS21050	COG1595	DNA-templated transcription, initiation
C1S78_RS21065	COG1686	Belongs to the peptidase S11 family
C1S78_RS21070	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C1S78_RS21125	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C1S78_RS21140	COG2072	flavoprotein involved in K transport
C1S78_RS21200	COG2188	Transcriptional regulator
C1S78_RS21205	COG2814	Major facilitator Superfamily
C1S78_RS21210	COG2971	BadF BadG BcrA BcrD
C1S78_RS21215	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C1S78_RS21220	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C1S78_RS21260	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C1S78_RS21310	COG0842	Transport permease protein
C1S78_RS21310	COG1131	(ABC) transporter
C1S78_RS21310	COG1716	ATPase activity
C1S78_RS21315	COG1357	PFAM Pentapeptide repeats (8 copies)
C1S78_RS21320	COG3757	hydrolase, family 25
C1S78_RS21335	COG2018	Roadblock/LC7 domain
C1S78_RS21340	COG2205	protein histidine kinase activity
C1S78_RS21350	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C1S78_RS21365	COG0587	DNA-directed DNA polymerase activity
C1S78_RS21380	COG4552	Acetyltransferase involved in intracellular survival and related
C1S78_RS21390	COG1454	alcohol dehydrogenase
C1S78_RS21395	COG4585	Histidine kinase
C1S78_RS21410	COG2031	fatty acid transporter
C1S78_RS21420	COG3415	Transposase
C1S78_RS21420	COG2801	Transposase and inactivated derivatives
C1S78_RS21435	COG0657	acetylesterase activity
C1S78_RS21460	COG0784	Response regulator, receiver
C1S78_RS21465	COG4251	negative regulation of phosphorylation
C1S78_RS21470	COG2204	response regulator
C1S78_RS21500	COG0784	Response regulator, receiver
C1S78_RS21555	COG1846	Transcriptional regulator
C1S78_RS21625	COG0069	glutamate synthase activity
C1S78_RS21630	COG0028	Belongs to the TPP enzyme family
C1S78_RS21635	COG2197	response regulator
C1S78_RS21655	COG0028	Belongs to the TPP enzyme family
C1S78_RS21665	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C1S78_RS21670	COG2080	2 iron, 2 sulfur cluster binding
C1S78_RS21675	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
C1S78_RS21680	COG1802	Transcriptional regulator
C1S78_RS21685	COG4721	ABC-type cobalt transport system, permease component
C1S78_RS21690	COG1122	ATPase activity
C1S78_RS21735	COG0745	RESPONSE REGULATOR receiver
C1S78_RS21740	COG2205	protein histidine kinase activity
C1S78_RS21755	COG0531	amino acid
C1S78_RS21770	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C1S78_RS21780	COG0252	asparaginase activity
C1S78_RS21785	COG2186	Transcriptional regulator
C1S78_RS21795	COG1027	Aspartate ammonia-lyase
C1S78_RS21805	COG0024	Methionine aminopeptidase
C1S78_RS21830	COG1278	Cold shock
C1S78_RS21840	COG2030	dehydratase
C1S78_RS21845	COG4221	oxidoreductase activity
C1S78_RS21860	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
C1S78_RS21865	COG2218	PFAM glutamate synthase alpha subunit domain protein
C1S78_RS21870	COG0069	glutamate synthase activity
C1S78_RS21880	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C1S78_RS21895	COG1764	response to oxidative stress
C1S78_RS21900	COG1846	Transcriptional regulator
C1S78_RS21930	COG0519	Catalyzes the synthesis of GMP from XMP
C1S78_RS21930	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C1S78_RS21960	COG0516	GMP reductase activity
C1S78_RS21995	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
C1S78_RS22005	COG0375	protein maturation
C1S78_RS22055	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
C1S78_RS22060	COG0298	carbon dioxide binding
C1S78_RS22065	COG0409	Hydrogenase expression formation protein
C1S78_RS22075	COG3263	regulation of cellular component size
C1S78_RS22095	COG1309	transcriptional regulator
C1S78_RS22115	COG1024	Enoyl-CoA hydratase
C1S78_RS22145	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C1S78_RS22165	COG2508	Transcriptional regulator
C1S78_RS22200	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C1S78_RS22205	COG0456	acetyltransferase
C1S78_RS22225	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C1S78_RS22230	COG0076	glutamate decarboxylase activity
C1S78_RS22245	COG1063	alcohol dehydrogenase
C1S78_RS22250	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C1S78_RS22250	COG2213	PTS system mannitol-specific
C1S78_RS22270	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C1S78_RS22320	COG1012	belongs to the aldehyde dehydrogenase family
C1S78_RS22325	COG4638	Rieske (2fe-2S)
C1S78_RS22340	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C1S78_RS22355	COG1802	Transcriptional regulator
C1S78_RS22360	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C1S78_RS22395	COG0446	pyridine nucleotide-disulphide oxidoreductase
C1S78_RS22395	COG1902	pentaerythritol trinitrate reductase activity
C1S78_RS22415	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C1S78_RS22420	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C1S78_RS22435	COG4303	Ethanolamine ammonia lyase large subunit
C1S78_RS22440	COG0531	amino acid
C1S78_RS22460	COG4842	Belongs to the WXG100 family
C1S78_RS22470	COG1674	ftsk spoiiie
C1S78_RS22480	COG1404	Belongs to the peptidase S8 family
C1S78_RS22515	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
C1S78_RS22525	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C1S78_RS22565	COG0203	ribosomal protein L17
C1S78_RS22570	COG0202	RNA polymerase activity
C1S78_RS22575	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C1S78_RS22580	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C1S78_RS22585	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C1S78_RS22590	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C1S78_RS22595	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C1S78_RS22600	COG0492	ferredoxin-NADP+ reductase activity
C1S78_RS22625	COG1595	DNA-templated transcription, initiation
C1S78_RS22640	COG1595	DNA-templated transcription, initiation
C1S78_RS22655	COG1960	acyl-CoA dehydrogenase activity
C1S78_RS22670	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C1S78_RS22695	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C1S78_RS22730	COG0563	adenylate kinase activity
C1S78_RS22740	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
C1S78_RS22745	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
C1S78_RS22755	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
C1S78_RS22775	COG0616	signal peptide processing
C1S78_RS22780	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C1S78_RS22785	COG0200	Binds to the 23S rRNA
C1S78_RS22790	COG1841	ribosomal large subunit assembly
C1S78_RS22795	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C1S78_RS22800	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C1S78_RS22810	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C1S78_RS22820	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C1S78_RS22835	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C1S78_RS22840	COG2855	membrane
C1S78_RS22850	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C1S78_RS22875	COG1595	DNA-templated transcription, initiation
C1S78_RS22885	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C1S78_RS22895	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C1S78_RS22900	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C1S78_RS22905	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C1S78_RS22910	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C1S78_RS22915	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C1S78_RS22925	COG0088	Forms part of the polypeptide exit tunnel
C1S78_RS22930	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C1S78_RS22935	COG0051	transcription antitermination factor activity, RNA binding
C1S78_RS22965	COG0477	Major facilitator Superfamily
C1S78_RS22995	COG0535	radical SAM domain protein
C1S78_RS23030	COG1834	amidinotransferase
C1S78_RS23035	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C1S78_RS23060	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C1S78_RS23065	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C1S78_RS23070	COG0049	tRNA binding
C1S78_RS23085	COG1309	transcriptional regulator
C1S78_RS23115	COG1960	acyl-CoA dehydrogenase activity
C1S78_RS23125	COG1113	amino acid transport
C1S78_RS23130	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
C1S78_RS23145	COG0644	oxidoreductase
C1S78_RS23160	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C1S78_RS23165	COG0085	RNA polymerase activity
C1S78_RS23175	COG0222	ribosome binding
C1S78_RS23180	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C1S78_RS23200	COG1733	regulation of RNA biosynthetic process
C1S78_RS23250	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C1S78_RS23255	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C1S78_RS23290	COG2072	flavoprotein involved in K transport
C1S78_RS23295	COG2072	flavoprotein involved in K transport
C1S78_RS23310	COG0081	regulation of translation
C1S78_RS23325	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C1S78_RS23340	COG2030	dehydratase
C1S78_RS23345	COG2030	dehydratase
C1S78_RS23350	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C1S78_RS23365	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C1S78_RS23380	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
C1S78_RS23385	COG1074	ATP-dependent DNA helicase activity
C1S78_RS23395	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C1S78_RS23410	COG1376	ErfK ybiS ycfS ynhG family protein
C1S78_RS23435	COG0583	DNA-binding transcription factor activity
C1S78_RS23445	COG0640	Transcriptional regulator
C1S78_RS23465	COG0701	Predicted permease
C1S78_RS23470	COG0596	Alpha beta hydrolase
C1S78_RS23480	COG1666	GTP binding
C1S78_RS23510	COG2205	protein histidine kinase activity
C1S78_RS23515	COG0745	RESPONSE REGULATOR receiver
C1S78_RS23520	COG0659	secondary active sulfate transmembrane transporter activity
C1S78_RS23525	COG1396	sequence-specific DNA binding
C1S78_RS23545	COG0501	Belongs to the peptidase M48B family
C1S78_RS23550	COG0142	geranyltranstransferase activity
C1S78_RS23555	COG0644	oxidoreductase
C1S78_RS23565	COG3123	guanosine phosphorylase activity
C1S78_RS23575	COG2226	methyltransferase
C1S78_RS23580	COG4221	oxidoreductase activity
C1S78_RS23590	COG0438	transferase activity, transferring glycosyl groups
C1S78_RS23605	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
C1S78_RS23620	COG4977	sequence-specific DNA binding
C1S78_RS23665	COG4948	Mandelate Racemase Muconate Lactonizing
C1S78_RS23675	COG1228	amidohydrolase
C1S78_RS23680	COG0318	PFAM AMP-dependent synthetase and ligase
C1S78_RS23685	COG2186	Transcriptional regulator
C1S78_RS23690	COG2807	transmembrane transport
C1S78_RS23710	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
C1S78_RS23720	COG0778	Nitroreductase
C1S78_RS23725	COG4221	oxidoreductase activity
C1S78_RS23765	COG2070	2-Nitropropane dioxygenase
C1S78_RS23770	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
C1S78_RS23800	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C1S78_RS23810	COG0785	Cytochrome C biogenesis protein
C1S78_RS23820	COG0406	alpha-ribazole phosphatase activity
C1S78_RS23825	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C1S78_RS23835	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C1S78_RS23845	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C1S78_RS23855	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C1S78_RS23885	COG1960	acyl-CoA dehydrogenase activity
C1S78_RS23915	COG1648	precorrin-2 dehydrogenase activity
C1S78_RS23915	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C1S78_RS23920	COG0181	hydroxymethylbilane synthase activity
C1S78_RS23940	COG2030	dehydratase
C1S78_RS23995	COG5002	protein histidine kinase activity
C1S78_RS24010	COG0438	transferase activity, transferring glycosyl groups
C1S78_RS24045	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C1S78_RS24060	COG1472	Belongs to the glycosyl hydrolase 3 family
C1S78_RS24100	COG2733	membrane
C1S78_RS24110	COG2326	polyphosphate kinase activity
C1S78_RS24115	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C1S78_RS24125	COG2224	Isocitrate lyase
C1S78_RS24160	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C1S78_RS24165	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C1S78_RS24175	COG1505	serine-type exopeptidase activity
C1S78_RS24185	COG2326	polyphosphate kinase activity
C1S78_RS24190	COG1012	belongs to the aldehyde dehydrogenase family
C1S78_RS24215	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
C1S78_RS24260	COG0714	Associated with various cellular activities
C1S78_RS24270	COG0459	protein refolding
C1S78_RS24285	COG1028	Short-chain dehydrogenase reductase Sdr
C1S78_RS24325	COG1309	transcriptional regulator
C1S78_RS24335	COG0647	UMP catabolic process
C1S78_RS24355	COG1183	phosphatidylcholine synthase activity
C1S78_RS24360	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C1S78_RS24370	COG2072	flavoprotein involved in K transport
C1S78_RS24395	COG5479	isomerase activity
C1S78_RS24395	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
C1S78_RS24410	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C1S78_RS24410	COG2111	Na H antiporter
C1S78_RS24420	COG0651	ATP synthesis coupled electron transport
C1S78_RS24430	COG2212	antiporter activity
C1S78_RS24480	COG0242	peptide deformylase activity
C1S78_RS24520	COG0657	acetylesterase activity
C1S78_RS24530	COG2409	Drug exporters of the RND superfamily
C1S78_RS24540	COG1403	HNH endonuclease
C1S78_RS24565	COG2072	flavoprotein involved in K transport
C1S78_RS24585	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C1S78_RS24590	COG2814	Major facilitator Superfamily
C1S78_RS24600	COG0351	phosphomethylpyrimidine kinase
C1S78_RS24635	COG2234	aminopeptidase activity
C1S78_RS24640	COG2234	aminopeptidase activity
C1S78_RS24690	COG2022	thiamine diphosphate biosynthetic process
C1S78_RS24700	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C1S78_RS24700	COG2022	thiamine diphosphate biosynthetic process
C1S78_RS24705	COG0352	thiamine-phosphate diphosphorylase activity
C1S78_RS24720	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1S78_RS24725	COG0515	serine threonine protein kinase
C1S78_RS24735	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C1S78_RS24745	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C1S78_RS24750	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C1S78_RS24765	COG4221	oxidoreductase activity
C1S78_RS24780	COG1073	alpha beta
C1S78_RS24790	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C1S78_RS24800	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C1S78_RS24810	COG0583	DNA-binding transcription factor activity
C1S78_RS24845	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
C1S78_RS24880	COG0739	heme binding
C1S78_RS24890	COG2409	Drug exporters of the RND superfamily
C1S78_RS24900	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C1S78_RS24910	COG1994	Peptidase M50
C1S78_RS24940	COG0586	Pfam SNARE associated Golgi protein
C1S78_RS24990	COG2197	response regulator
C1S78_RS25035	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C1S78_RS25060	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C1S78_RS25065	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C1S78_RS25070	COG1028	Short-chain dehydrogenase reductase Sdr
C1S78_RS25080	COG1960	acyl-CoA dehydrogenase activity
C1S78_RS25085	COG1960	acyl-CoA dehydrogenase activity
C1S78_RS25090	COG0318	PFAM AMP-dependent synthetase and ligase
C1S78_RS25105	COG2070	2-Nitropropane dioxygenase
C1S78_RS25115	COG1024	Enoyl-CoA hydratase
C1S78_RS25130	COG2124	cytochrome p450
C1S78_RS25140	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C1S78_RS25175	COG4638	Rieske (2fe-2S)
C1S78_RS25220	COG0514	ATP-dependent DNA helicase (RecQ)
C1S78_RS25230	COG0701	Predicted permease
C1S78_RS25240	COG0300	oxidoreductase activity
C1S78_RS25245	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C1S78_RS25255	COG4569	acetaldehyde dehydrogenase (acetylating) activity
C1S78_RS25260	COG3971	2-oxopent-4-enoate hydratase activity
C1S78_RS25265	COG1053	succinate dehydrogenase
C1S78_RS25270	COG2030	dehydratase
C1S78_RS25305	COG2030	dehydratase
C1S78_RS25310	COG1960	acyl-CoA dehydrogenase activity
C1S78_RS25315	COG1960	acyl-CoA dehydrogenase activity
C1S78_RS25320	COG2124	cytochrome p450
C1S78_RS25325	COG0183	Belongs to the thiolase family
C1S78_RS25340	COG0406	alpha-ribazole phosphatase activity
C1S78_RS25350	COG1028	Short-chain dehydrogenase reductase Sdr
C1S78_RS25355	COG1028	Short-chain dehydrogenase reductase Sdr
C1S78_RS25360	COG1024	Enoyl-CoA hydratase
C1S78_RS25395	COG0243	molybdopterin cofactor binding
C1S78_RS25400	COG0583	DNA-binding transcription factor activity
C1S78_RS25415	COG1028	Short-chain dehydrogenase reductase Sdr
C1S78_RS25430	COG0183	Belongs to the thiolase family
C1S78_RS25435	COG1309	transcriptional regulator
C1S78_RS25455	COG5002	protein histidine kinase activity
C1S78_RS25460	COG0745	RESPONSE REGULATOR receiver
C1S78_RS25470	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C1S78_RS25475	COG1028	Short-chain dehydrogenase reductase Sdr
C1S78_RS25480	COG1960	acyl-CoA dehydrogenase activity
C1S78_RS25485	COG0318	PFAM AMP-dependent synthetase and ligase
C1S78_RS25490	COG1960	acyl-CoA dehydrogenase activity
C1S78_RS25495	COG1960	acyl-CoA dehydrogenase activity
C1S78_RS25500	COG1960	acyl-CoA dehydrogenase activity
C1S78_RS25505	COG1228	amidohydrolase
C1S78_RS25510	COG0402	S-adenosylhomocysteine deaminase activity
C1S78_RS25520	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
C1S78_RS25550	COG2986	histidine ammonia-lyase
C1S78_RS25555	COG2986	histidine ammonia-lyase
C1S78_RS25560	COG0436	Aminotransferase
C1S78_RS25580	COG0346	lactoylglutathione lyase activity
C1S78_RS25595	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C1S78_RS25605	COG3903	Transcriptional regulator
C1S78_RS25605	COG3629	intracellular signal transduction
C1S78_RS25645	COG1846	Transcriptional regulator
C1S78_RS25650	COG1764	response to oxidative stress
C1S78_RS25665	COG0657	acetylesterase activity
C1S78_RS25670	COG1609	Transcriptional regulator
C1S78_RS25670	COG2207	Transcriptional regulator
C1S78_RS25675	COG1960	acyl-CoA dehydrogenase activity
C1S78_RS25680	COG1309	transcriptional regulator
C1S78_RS25690	COG1609	Transcriptional regulator
C1S78_RS25700	COG1116	anion transmembrane transporter activity
C1S78_RS25715	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
C1S78_RS25735	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C1S78_RS25740	COG0215	cysteine-tRNA ligase activity
C1S78_RS25745	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C1S78_RS25750	COG1329	Transcriptional regulator
C1S78_RS25765	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
C1S78_RS25770	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
C1S78_RS25785	COG1194	a g-specific adenine glycosylase
C1S78_RS25825	COG1309	transcriptional regulator
C1S78_RS25835	COG3800	Transcriptional regulator
C1S78_RS25835	COG1396	sequence-specific DNA binding
C1S78_RS25845	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
C1S78_RS25870	COG0393	Putative heavy-metal-binding
C1S78_RS25895	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C1S78_RS25905	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
C1S78_RS25915	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C1S78_RS25945	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C1S78_RS25950	COG0302	gtp cyclohydrolase
C1S78_RS25955	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C1S78_RS25960	COG2267	carboxylic ester hydrolase activity
C1S78_RS25975	COG3383	formate dehydrogenase (NAD+) activity
C1S78_RS25995	COG2027	D-alanyl-D-alanine carboxypeptidase
C1S78_RS26090	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C1S78_RS26110	COG4974	Belongs to the 'phage' integrase family
C1S78_RS26175	COG3179	chitinase
C1S78_RS26460	COG0470	DNA polymerase III
C1S78_RS26470	COG1754	DNA topoisomerase type I activity
C1S78_RS26470	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C1S78_RS26480	COG1278	Cold shock
C1S78_RS26485	COG1205	dead DEAH box helicase
C1S78_RS26485	COG1111	helicase
C1S78_RS26580	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C1S78_RS26630	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C1S78_RS26660	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C1S78_RS26665	COG1408	metallophosphoesterase
C1S78_RS26670	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C1S78_RS26680	COG1309	transcriptional regulator
C1S78_RS26685	COG0477	Major facilitator Superfamily
C1S78_RS26695	COG0475	glutathione-regulated potassium exporter activity
C1S78_RS26695	COG0589	response to stress
C1S78_RS26705	COG0667	Aldo Keto reductase
C1S78_RS26720	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C1S78_RS26725	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
C1S78_RS26735	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C1S78_RS26740	COG3572	ergothioneine biosynthetic process
C1S78_RS26750	COG1028	Short-chain dehydrogenase reductase Sdr
C1S78_RS26760	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C1S78_RS26780	COG4290	ribonuclease
C1S78_RS26810	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C1S78_RS26840	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
C1S78_RS26850	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C1S78_RS26855	COG1088	dTDP-glucose 4,6-dehydratase activity
C1S78_RS26860	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C1S78_RS26865	COG1492	cobalamin metabolic process
C1S78_RS26875	COG3321	synthase
C1S78_RS26875	COG0604	alcohol dehydrogenase
C1S78_RS26895	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C1S78_RS26905	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C1S78_RS26910	COG1028	Short-chain dehydrogenase reductase Sdr
C1S78_RS26915	COG2188	Transcriptional regulator
C1S78_RS26970	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C1S78_RS26980	COG0222	ribosome binding
C1S78_RS26985	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C1S78_RS27005	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C1S78_RS27035	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1S78_RS27045	COG0747	negative chemotaxis
C1S78_RS27070	COG1793	dna ligase
C1S78_RS27075	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C1S78_RS27080	COG0300	oxidoreductase activity
C1S78_RS27090	COG0343	queuine tRNA-ribosyltransferase activity
C1S78_RS27115	COG0531	amino acid
C1S78_RS27145	COG0318	PFAM AMP-dependent synthetase and ligase
C1S78_RS27180	COG0287	Prephenate dehydrogenase
C1S78_RS27195	COG1174	glycine betaine transport
C1S78_RS27200	COG1125	glycine betaine transport
C1S78_RS27200	COG0517	IMP dehydrogenase activity
C1S78_RS27210	COG5416	Lipopolysaccharide assembly protein A domain
C1S78_RS27245	COG1028	Short-chain dehydrogenase reductase Sdr
C1S78_RS27260	COG2015	COG2015, Alkyl sulfatase and related hydrolases
C1S78_RS27285	COG1033	growth of symbiont in host cell
C1S78_RS27285	COG2409	Drug exporters of the RND superfamily
C1S78_RS27365	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
C1S78_RS27670	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C1S78_RS27685	COG1968	undecaprenyl-diphosphatase activity
C1S78_RS27735	COG0300	oxidoreductase activity
C1S78_RS27780	COG0604	alcohol dehydrogenase
C1S78_RS27810	COG1216	Glycosyl transferase, family 2
C1S78_RS27830	COG1733	regulation of RNA biosynthetic process
C1S78_RS27840	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C1S78_RS27845	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C1S78_RS27860	COG0277	FAD linked oxidase domain protein
C1S78_RS27865	COG1028	Short-chain dehydrogenase reductase Sdr
C1S78_RS27890	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C1S78_RS27915	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C1S78_RS27955	COG1140	nitrate reductase beta subunit
C1S78_RS27985	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C1S78_RS27990	COG3321	synthase
C1S78_RS27990	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
C1S78_RS27990	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C1S78_RS27995	COG0318	PFAM AMP-dependent synthetase and ligase
C1S78_RS28000	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
C1S78_RS28010	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
C1S78_RS28015	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C1S78_RS28020	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
C1S78_RS28025	COG0671	phosphoesterase, PA-phosphatase related
C1S78_RS28030	COG1216	Glycosyl transferase, family 2
C1S78_RS28050	COG0561	phosphatase activity
C1S78_RS28060	COG0204	Acyl-transferase
C1S78_RS28070	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C1S78_RS28070	COG2146	nitrite reductase [NAD(P)H] activity
C1S78_RS28095	COG2801	Transposase and inactivated derivatives
C1S78_RS28095	COG3415	Transposase
C1S78_RS28100	COG3903	Transcriptional regulator
C1S78_RS28100	COG3629	intracellular signal transduction
C1S78_RS28105	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C1S78_RS28125	COG0406	alpha-ribazole phosphatase activity
C1S78_RS28145	COG1528	Iron-storage protein
C1S78_RS28170	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C1S78_RS28210	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C1S78_RS28215	COG2072	flavoprotein involved in K transport
C1S78_RS28220	COG1309	transcriptional regulator
C1S78_RS28235	COG1309	transcriptional regulator
C1S78_RS28240	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C1S78_RS28285	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C1S78_RS28285	COG1796	DNA polymerase
C1S78_RS28325	COG0070	glutamate synthase
C1S78_RS28325	COG0069	glutamate synthase activity
C1S78_RS28325	COG0067	glutamate synthase
C1S78_RS28355	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
C1S78_RS28360	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C1S78_RS28370	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C1S78_RS28375	COG0596	Alpha beta hydrolase
C1S78_RS28395	COG1335	isochorismatase
C1S78_RS28400	COG1024	Enoyl-CoA hydratase
C1S78_RS28410	COG1129	ABC transporter
C1S78_RS28410	COG0842	Transport permease protein
C1S78_RS28430	COG3281	Trehalose synthase
C1S78_RS28445	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C1S78_RS28475	COG3320	Male sterility
C1S78_RS28475	COG1022	Amp-dependent synthetase and ligase
C1S78_RS28480	COG1022	Amp-dependent synthetase and ligase
C1S78_RS28480	COG3320	Male sterility
C1S78_RS28490	COG1028	Short-chain dehydrogenase reductase Sdr
C1S78_RS28495	COG1063	alcohol dehydrogenase
C1S78_RS28520	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C1S78_RS28525	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C1S78_RS28535	COG1946	Acyl-CoA thioesterase
C1S78_RS28570	COG1028	Short-chain dehydrogenase reductase Sdr
C1S78_RS28605	COG1012	belongs to the aldehyde dehydrogenase family
C1S78_RS28610	COG0129	dihydroxy-acid dehydratase activity
C1S78_RS28620	COG0860	N-Acetylmuramoyl-L-alanine amidase
C1S78_RS28645	COG1643	Atp-dependent helicase
C1S78_RS28655	COG1309	transcriptional regulator
C1S78_RS28665	COG1960	acyl-CoA dehydrogenase activity
C1S78_RS28690	COG3961	Belongs to the TPP enzyme family
C1S78_RS28705	COG2226	methyltransferase
C1S78_RS28725	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C1S78_RS28755	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C1S78_RS28780	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C1S78_RS28800	COG0657	acetylesterase activity
C1S78_RS28820	COG1960	acyl-CoA dehydrogenase activity
C1S78_RS28850	COG1376	ErfK ybiS ycfS ynhG family protein
C1S78_RS28885	COG1234	tRNA 3'-trailer cleavage
C1S78_RS28940	COG2207	Transcriptional regulator
C1S78_RS28945	COG0300	oxidoreductase activity
C1S78_RS28950	COG1231	oxidoreductase activity
C1S78_RS28965	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C1S78_RS28980	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C1S78_RS28990	COG2030	dehydratase
C1S78_RS29025	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C1S78_RS29070	COG1113	amino acid transport
C1S78_RS29075	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C1S78_RS29090	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
C1S78_RS29130	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C1S78_RS29140	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C1S78_RS29145	COG0174	glutamine synthetase
C1S78_RS29155	COG1464	Belongs to the NlpA lipoprotein family
C1S78_RS29160	COG0745	RESPONSE REGULATOR receiver
C1S78_RS29165	COG3757	hydrolase, family 25
C1S78_RS29175	COG0488	(ABC) transporter
C1S78_RS29260	COG1396	sequence-specific DNA binding
C1S78_RS29290	COG1309	transcriptional regulator
C1S78_RS29310	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C1S78_RS29315	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
C1S78_RS29350	COG0318	PFAM AMP-dependent synthetase and ligase
C1S78_RS29365	COG1024	Enoyl-CoA hydratase
C1S78_RS29365	COG1250	3-hydroxyacyl-CoA dehydrogenase
C1S78_RS29370	COG1028	Short-chain dehydrogenase reductase Sdr
C1S78_RS29380	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C1S78_RS29415	COG0305	Participates in initiation and elongation during chromosome replication
C1S78_RS29425	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C1S78_RS29430	COG0629	single-stranded DNA binding
C1S78_RS29435	COG0360	Binds together with S18 to 16S ribosomal RNA
C1S78_RS29465	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C1S78_RS29485	COG1260	myo-inositol-1-phosphate synthase
C1S78_RS29495	COG3634	alkyl hydroperoxide reductase activity
C1S78_RS29500	COG0596	Alpha beta hydrolase
C1S78_RS29500	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C1S78_RS29510	COG0765	amino acid transport
C1S78_RS29515	COG1126	abc transporter atp-binding protein
C1S78_RS29525	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
C1S78_RS29530	COG4221	oxidoreductase activity
C1S78_RS29535	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C1S78_RS29545	COG0495	leucyl-tRNA aminoacylation
C1S78_RS29560	COG1678	Uncharacterized ACR, COG1678
C1S78_RS29605	COG1595	DNA-templated transcription, initiation
C1S78_RS29625	COG0860	N-Acetylmuramoyl-L-alanine amidase
C1S78_RS29625	COG3409	Peptidoglycan-binding domain 1 protein
C1S78_RS29635	COG2814	Major facilitator Superfamily
C1S78_RS29650	COG2267	carboxylic ester hydrolase activity
C1S78_RS29665	COG1192	Involved in chromosome partitioning
C1S78_RS29670	COG0357	Ribosomal RNA small subunit methyltransferase G
C1S78_RS29680	COG0706	membrane insertase activity
C1S78_RS29685	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C1S78_RS29690	COG0594	ribonuclease P activity
C1S78_RS29695	COG0230	Belongs to the bacterial ribosomal protein bL34 family