locus-tag	class	description
MPHLCCUG_RS00010	COG0592	DNA-directed DNA polymerase activity
MPHLCCUG_RS00015	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
MPHLCCUG_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
MPHLCCUG_RS00025	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
MPHLCCUG_RS00030	COG0187	DNA topoisomerase II activity
MPHLCCUG_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MPHLCCUG_RS00060	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
MPHLCCUG_RS00085	COG0515	serine threonine protein kinase
MPHLCCUG_RS00085	COG2815	serine threonine protein kinase
MPHLCCUG_RS00090	COG0515	serine threonine protein kinase
MPHLCCUG_RS00095	COG0768	penicillin binding
MPHLCCUG_RS00110	COG1716	ATPase activity
MPHLCCUG_RS00115	COG1716	ATPase activity
MPHLCCUG_RS00135	COG0243	molybdopterin cofactor binding
MPHLCCUG_RS00145	COG0748	coenzyme F420 binding
MPHLCCUG_RS00170	COG1673	EVE domain
MPHLCCUG_RS00205	COG0464	growth
MPHLCCUG_RS00235	COG4842	Belongs to the WXG100 family
MPHLCCUG_RS00240	COG4842	Belongs to the WXG100 family
MPHLCCUG_RS00310	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
MPHLCCUG_RS00315	COG1012	belongs to the aldehyde dehydrogenase family
MPHLCCUG_RS00320	COG1028	Short-chain dehydrogenase reductase Sdr
MPHLCCUG_RS00325	COG3321	synthase
MPHLCCUG_RS00325	COG1028	Short-chain dehydrogenase reductase Sdr
MPHLCCUG_RS00325	COG0604	alcohol dehydrogenase
MPHLCCUG_RS00350	COG2365	Tyrosine phosphatase family
MPHLCCUG_RS00355	COG1960	acyl-CoA dehydrogenase activity
MPHLCCUG_RS00375	COG4585	Histidine kinase
MPHLCCUG_RS00380	COG1960	acyl-CoA dehydrogenase activity
MPHLCCUG_RS00390	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
MPHLCCUG_RS00410	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MPHLCCUG_RS00415	COG4521	taurine ABC transporter
MPHLCCUG_RS00420	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
MPHLCCUG_RS00425	COG1309	transcriptional regulator
MPHLCCUG_RS00430	COG1960	acyl-CoA dehydrogenase activity
MPHLCCUG_RS00440	COG0824	Thioesterase
MPHLCCUG_RS00460	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
MPHLCCUG_RS00465	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
MPHLCCUG_RS00490	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
MPHLCCUG_RS00520	COG3619	membrane
MPHLCCUG_RS00525	COG0300	oxidoreductase activity
MPHLCCUG_RS00565	COG2267	carboxylic ester hydrolase activity
MPHLCCUG_RS00600	COG1404	Belongs to the peptidase S8 family
MPHLCCUG_RS00605	COG0438	transferase activity, transferring glycosyl groups
MPHLCCUG_RS00660	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MPHLCCUG_RS00680	COG0783	Belongs to the Dps family
MPHLCCUG_RS00705	COG0069	glutamate synthase activity
MPHLCCUG_RS00705	COG0070	glutamate synthase
MPHLCCUG_RS00705	COG0067	glutamate synthase
MPHLCCUG_RS00750	COG0659	secondary active sulfate transmembrane transporter activity
MPHLCCUG_RS00760	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
MPHLCCUG_RS00760	COG1796	DNA polymerase
MPHLCCUG_RS00765	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MPHLCCUG_RS00775	COG2072	flavoprotein involved in K transport
MPHLCCUG_RS00780	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
MPHLCCUG_RS00785	COG0789	Transcriptional regulator
MPHLCCUG_RS00830	COG2119	membrane
MPHLCCUG_RS00865	COG1528	Iron-storage protein
MPHLCCUG_RS00870	COG1316	TRANSCRIPTIONal
MPHLCCUG_RS00915	COG1063	alcohol dehydrogenase
MPHLCCUG_RS00930	COG2146	nitrite reductase [NAD(P)H] activity
MPHLCCUG_RS00930	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
MPHLCCUG_RS00935	COG0204	Acyl-transferase
MPHLCCUG_RS00945	COG0561	phosphatase activity
MPHLCCUG_RS00965	COG1216	Glycosyl transferase, family 2
MPHLCCUG_RS00970	COG0671	phosphoesterase, PA-phosphatase related
MPHLCCUG_RS00975	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
MPHLCCUG_RS00980	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
MPHLCCUG_RS00990	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
MPHLCCUG_RS01005	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
MPHLCCUG_RS01010	COG0318	PFAM AMP-dependent synthetase and ligase
MPHLCCUG_RS01015	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
MPHLCCUG_RS01015	COG3321	synthase
MPHLCCUG_RS01015	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MPHLCCUG_RS01020	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
MPHLCCUG_RS01050	COG1028	Short-chain dehydrogenase reductase Sdr
MPHLCCUG_RS01055	COG0277	FAD linked oxidase domain protein
MPHLCCUG_RS01065	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MPHLCCUG_RS01070	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
MPHLCCUG_RS01080	COG1216	Glycosyl transferase, family 2
MPHLCCUG_RS01100	COG0604	alcohol dehydrogenase
MPHLCCUG_RS01155	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
MPHLCCUG_RS01185	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MPHLCCUG_RS01220	COG3835	regulator
MPHLCCUG_RS01255	COG2015	COG2015, Alkyl sulfatase and related hydrolases
MPHLCCUG_RS01260	COG2346	COG2346, Truncated hemoglobins
MPHLCCUG_RS01265	COG1028	Short-chain dehydrogenase reductase Sdr
MPHLCCUG_RS01280	COG5416	Lipopolysaccharide assembly protein A domain
MPHLCCUG_RS01295	COG1174	glycine betaine transport
MPHLCCUG_RS01300	COG1174	glycine betaine transport
MPHLCCUG_RS01310	COG0287	Prephenate dehydrogenase
MPHLCCUG_RS01320	COG0590	tRNA wobble adenosine to inosine editing
MPHLCCUG_RS01330	COG2197	response regulator
MPHLCCUG_RS01335	COG4251	negative regulation of phosphorylation
MPHLCCUG_RS01340	COG0784	Response regulator, receiver
MPHLCCUG_RS01370	COG0343	queuine tRNA-ribosyltransferase activity
MPHLCCUG_RS01385	COG0427	acetyl-CoA hydrolase
MPHLCCUG_RS01390	COG1126	abc transporter atp-binding protein
MPHLCCUG_RS01405	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MPHLCCUG_RS01410	COG0477	Major facilitator Superfamily
MPHLCCUG_RS01415	COG2188	Transcriptional regulator
MPHLCCUG_RS01420	COG1028	Short-chain dehydrogenase reductase Sdr
MPHLCCUG_RS01430	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
MPHLCCUG_RS01450	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
MPHLCCUG_RS01455	COG1012	belongs to the aldehyde dehydrogenase family
MPHLCCUG_RS01455	COG1454	alcohol dehydrogenase
MPHLCCUG_RS01480	COG1793	dna ligase
MPHLCCUG_RS01505	COG1793	dna ligase
MPHLCCUG_RS01525	COG0443	Heat shock 70 kDa protein
MPHLCCUG_RS01540	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MPHLCCUG_RS01560	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MPHLCCUG_RS01575	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
MPHLCCUG_RS01590	COG0860	N-Acetylmuramoyl-L-alanine amidase
MPHLCCUG_RS01615	COG1492	cobalamin metabolic process
MPHLCCUG_RS01620	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
MPHLCCUG_RS01625	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
MPHLCCUG_RS01635	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MPHLCCUG_RS01650	COG0069	glutamate synthase activity
MPHLCCUG_RS01655	COG2218	PFAM glutamate synthase alpha subunit domain protein
MPHLCCUG_RS01660	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
MPHLCCUG_RS01725	COG1960	acyl-CoA dehydrogenase activity
MPHLCCUG_RS01735	COG1764	response to oxidative stress
MPHLCCUG_RS01745	COG3572	ergothioneine biosynthetic process
MPHLCCUG_RS01750	COG1262	PFAM Formylglycine-generating sulfatase enzyme
MPHLCCUG_RS01760	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
MPHLCCUG_RS01765	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MPHLCCUG_RS01790	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
MPHLCCUG_RS01795	COG0667	Aldo Keto reductase
MPHLCCUG_RS01815	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
MPHLCCUG_RS01835	COG0714	Associated with various cellular activities
MPHLCCUG_RS01855	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MPHLCCUG_RS01865	COG2264	protein methyltransferase activity
MPHLCCUG_RS01895	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
MPHLCCUG_RS01900	COG1408	metallophosphoesterase
MPHLCCUG_RS01905	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
MPHLCCUG_RS01925	COG0251	oxidation-reduction process
MPHLCCUG_RS01930	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MPHLCCUG_RS01955	COG0494	nUDIX hydrolase
MPHLCCUG_RS01980	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MPHLCCUG_RS02035	COG1111	helicase
MPHLCCUG_RS02035	COG1205	dead DEAH box helicase
MPHLCCUG_RS02040	COG1278	Cold shock
MPHLCCUG_RS02050	COG1754	DNA topoisomerase type I activity
MPHLCCUG_RS02050	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MPHLCCUG_RS02060	COG0470	DNA polymerase III
MPHLCCUG_RS02070	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
MPHLCCUG_RS02125	COG2027	D-alanyl-D-alanine carboxypeptidase
MPHLCCUG_RS02145	COG0243	molybdopterin cofactor binding
MPHLCCUG_RS02155	COG2267	carboxylic ester hydrolase activity
MPHLCCUG_RS02160	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MPHLCCUG_RS02165	COG0302	gtp cyclohydrolase
MPHLCCUG_RS02200	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
MPHLCCUG_RS02210	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
MPHLCCUG_RS02220	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
MPHLCCUG_RS02230	COG0542	response to heat
MPHLCCUG_RS02275	COG1194	a g-specific adenine glycosylase
MPHLCCUG_RS02280	COG0288	reversible hydration of carbon dioxide
MPHLCCUG_RS02290	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
MPHLCCUG_RS02295	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
MPHLCCUG_RS02305	COG1329	Transcriptional regulator
MPHLCCUG_RS02310	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
MPHLCCUG_RS02315	COG0215	cysteine-tRNA ligase activity
MPHLCCUG_RS02320	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MPHLCCUG_RS02325	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
MPHLCCUG_RS02340	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MPHLCCUG_RS02345	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
MPHLCCUG_RS02355	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
MPHLCCUG_RS02360	COG0778	Nitroreductase
MPHLCCUG_RS02370	COG0803	Belongs to the bacterial solute-binding protein 9 family
MPHLCCUG_RS02375	COG1121	(ABC) transporter
MPHLCCUG_RS02385	COG1609	Transcriptional regulator
MPHLCCUG_RS02400	COG1309	transcriptional regulator
MPHLCCUG_RS02405	COG1960	acyl-CoA dehydrogenase activity
MPHLCCUG_RS02410	COG2801	Transposase and inactivated derivatives
MPHLCCUG_RS02410	COG3415	Transposase
MPHLCCUG_RS02420	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
MPHLCCUG_RS02450	COG0583	DNA-binding transcription factor activity
MPHLCCUG_RS02460	COG1028	Short-chain dehydrogenase reductase Sdr
MPHLCCUG_RS02475	COG1940	carbohydrate kinase activity
MPHLCCUG_RS02480	COG2115	Belongs to the xylose isomerase family
MPHLCCUG_RS02485	COG4213	ABC transporter substrate-binding protein
MPHLCCUG_RS02495	COG4214	carbohydrate transport
MPHLCCUG_RS02500	COG0436	Aminotransferase
MPHLCCUG_RS02505	COG1960	acyl-CoA dehydrogenase activity
MPHLCCUG_RS02515	COG1960	acyl-CoA dehydrogenase activity
MPHLCCUG_RS02520	COG0318	PFAM AMP-dependent synthetase and ligase
MPHLCCUG_RS02525	COG1960	acyl-CoA dehydrogenase activity
MPHLCCUG_RS02540	COG0183	Belongs to the thiolase family
MPHLCCUG_RS02585	COG1024	Enoyl-CoA hydratase
MPHLCCUG_RS02590	COG1028	Short-chain dehydrogenase reductase Sdr
MPHLCCUG_RS02595	COG1028	Short-chain dehydrogenase reductase Sdr
MPHLCCUG_RS02610	COG0406	alpha-ribazole phosphatase activity
MPHLCCUG_RS02620	COG0183	Belongs to the thiolase family
MPHLCCUG_RS02625	COG2124	cytochrome p450
MPHLCCUG_RS02630	COG1960	acyl-CoA dehydrogenase activity
MPHLCCUG_RS02635	COG1960	acyl-CoA dehydrogenase activity
MPHLCCUG_RS02640	COG2030	dehydratase
MPHLCCUG_RS02675	COG2963	transposase activity
MPHLCCUG_RS02680	COG2801	Transposase and inactivated derivatives
MPHLCCUG_RS02690	COG2801	Transposase and inactivated derivatives
MPHLCCUG_RS02710	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
MPHLCCUG_RS02720	COG3800	Transcriptional regulator
MPHLCCUG_RS02720	COG1396	sequence-specific DNA binding
MPHLCCUG_RS02725	COG2301	Belongs to the HpcH HpaI aldolase family
MPHLCCUG_RS02730	COG1804	L-carnitine dehydratase bile acid-inducible protein F
MPHLCCUG_RS02765	COG2030	dehydratase
MPHLCCUG_RS02770	COG1053	succinate dehydrogenase
MPHLCCUG_RS02775	COG3971	2-oxopent-4-enoate hydratase activity
MPHLCCUG_RS02780	COG4569	acetaldehyde dehydrogenase (acetylating) activity
MPHLCCUG_RS02800	COG0514	ATP-dependent DNA helicase (RecQ)
MPHLCCUG_RS02815	COG1028	Short-chain dehydrogenase reductase Sdr
MPHLCCUG_RS02835	COG4638	Rieske (2fe-2S)
MPHLCCUG_RS02895	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MPHLCCUG_RS02905	COG2124	cytochrome p450
MPHLCCUG_RS02920	COG2070	2-Nitropropane dioxygenase
MPHLCCUG_RS02925	COG4638	Rieske (2fe-2S)
MPHLCCUG_RS02930	COG0318	PFAM AMP-dependent synthetase and ligase
MPHLCCUG_RS02945	COG0318	PFAM AMP-dependent synthetase and ligase
MPHLCCUG_RS02950	COG1960	acyl-CoA dehydrogenase activity
MPHLCCUG_RS02955	COG1960	acyl-CoA dehydrogenase activity
MPHLCCUG_RS02965	COG1028	Short-chain dehydrogenase reductase Sdr
MPHLCCUG_RS02970	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
MPHLCCUG_RS02975	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
MPHLCCUG_RS03000	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
MPHLCCUG_RS03035	COG1024	Enoyl-CoA hydratase
MPHLCCUG_RS03050	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MPHLCCUG_RS03055	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
MPHLCCUG_RS03060	COG2860	membrane
MPHLCCUG_RS03065	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MPHLCCUG_RS03105	COG2814	Major facilitator Superfamily
MPHLCCUG_RS03115	COG2130	NADP-dependent
MPHLCCUG_RS03130	COG1846	Transcriptional regulator
MPHLCCUG_RS03155	COG0745	RESPONSE REGULATOR receiver
MPHLCCUG_RS03160	COG2205	protein histidine kinase activity
MPHLCCUG_RS03170	COG1028	Short-chain dehydrogenase reductase Sdr
MPHLCCUG_RS03195	COG2124	cytochrome p450
MPHLCCUG_RS03200	COG4221	oxidoreductase activity
MPHLCCUG_RS03265	COG2124	cytochrome p450
MPHLCCUG_RS03285	COG0531	amino acid
MPHLCCUG_RS03295	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
MPHLCCUG_RS03315	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
MPHLCCUG_RS03335	COG0386	Belongs to the glutathione peroxidase family
MPHLCCUG_RS03345	COG3573	Dehydrogenase
MPHLCCUG_RS03360	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MPHLCCUG_RS03390	COG2837	iron assimilation
MPHLCCUG_RS03395	COG1362	aminopeptidase activity
MPHLCCUG_RS03405	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MPHLCCUG_RS03420	COG1028	Short-chain dehydrogenase reductase Sdr
MPHLCCUG_RS03435	COG0702	epimerase
MPHLCCUG_RS03440	COG2072	flavoprotein involved in K transport
MPHLCCUG_RS03450	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
MPHLCCUG_RS03455	COG1012	belongs to the aldehyde dehydrogenase family
MPHLCCUG_RS03460	COG0404	The glycine cleavage system catalyzes the degradation of glycine
MPHLCCUG_RS03475	COG4044	May play a role in the intracellular transport of hydrophobic ligands
MPHLCCUG_RS03485	COG2897	thiosulfate sulfurtransferase activity
MPHLCCUG_RS03505	COG0745	RESPONSE REGULATOR receiver
MPHLCCUG_RS03525	COG0581	inorganic phosphate transmembrane transporter activity
MPHLCCUG_RS03530	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
MPHLCCUG_RS03550	COG1316	TRANSCRIPTIONal
MPHLCCUG_RS03670	COG2169	Transcriptional regulator
MPHLCCUG_RS03670	COG1917	Cupin 2, conserved barrel domain protein
MPHLCCUG_RS03720	COG1953	Uracil, thiamine, allantoin
MPHLCCUG_RS03735	COG4266	Belongs to the allantoicase family
MPHLCCUG_RS03755	COG0829	nickel cation binding
MPHLCCUG_RS03760	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
MPHLCCUG_RS03765	COG0804	urea catabolic process
MPHLCCUG_RS03770	COG0832	Belongs to the urease beta subunit family
MPHLCCUG_RS03770	COG0831	urea catabolic process
MPHLCCUG_RS03780	COG2197	response regulator
MPHLCCUG_RS03785	COG0183	Belongs to the thiolase family
MPHLCCUG_RS03790	COG1024	Enoyl-CoA hydratase
MPHLCCUG_RS03790	COG1250	3-hydroxyacyl-CoA dehydrogenase
MPHLCCUG_RS03795	COG1309	transcriptional regulator
MPHLCCUG_RS03810	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MPHLCCUG_RS03825	COG1061	Type III restriction enzyme res subunit
MPHLCCUG_RS03845	COG0521	Mo-molybdopterin cofactor biosynthetic process
MPHLCCUG_RS03845	COG0315	cyclic pyranopterin monophosphate synthase activity
MPHLCCUG_RS03865	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
MPHLCCUG_RS03870	COG3304	Inner membrane component domain
MPHLCCUG_RS03875	COG1278	Cold shock
MPHLCCUG_RS03880	COG0435	Glutathione S-transferase
MPHLCCUG_RS03890	COG2814	Major facilitator Superfamily
MPHLCCUG_RS03915	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MPHLCCUG_RS03930	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
MPHLCCUG_RS03950	COG2723	6-phospho-beta-galactosidase activity
MPHLCCUG_RS03970	COG0259	pyridoxamine-phosphate oxidase activity
MPHLCCUG_RS03980	COG1309	transcriptional regulator
MPHLCCUG_RS03995	COG1846	Transcriptional regulator
MPHLCCUG_RS04010	COG0545	Peptidyl-prolyl cis-trans isomerase
MPHLCCUG_RS04020	COG0745	RESPONSE REGULATOR receiver
MPHLCCUG_RS04025	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
MPHLCCUG_RS04030	COG1132	(ABC) transporter
MPHLCCUG_RS04035	COG1132	(ABC) transporter
MPHLCCUG_RS04040	COG1132	(ABC) transporter
MPHLCCUG_RS04050	COG0596	Alpha beta hydrolase
MPHLCCUG_RS04080	COG1024	Enoyl-CoA hydratase
MPHLCCUG_RS04095	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
MPHLCCUG_RS04115	COG0318	PFAM AMP-dependent synthetase and ligase
MPHLCCUG_RS04120	COG1028	Short-chain dehydrogenase reductase Sdr
MPHLCCUG_RS04125	COG0318	PFAM AMP-dependent synthetase and ligase
MPHLCCUG_RS04130	COG2188	Transcriptional regulator
MPHLCCUG_RS04150	COG2072	flavoprotein involved in K transport
MPHLCCUG_RS04155	COG1028	Short-chain dehydrogenase reductase Sdr
MPHLCCUG_RS04165	COG1960	acyl-CoA dehydrogenase activity
MPHLCCUG_RS04175	COG1960	acyl-CoA dehydrogenase activity
MPHLCCUG_RS04180	COG1960	acyl-CoA dehydrogenase activity
MPHLCCUG_RS04235	COG1733	regulation of RNA biosynthetic process
MPHLCCUG_RS04240	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
MPHLCCUG_RS04265	COG1715	Restriction endonuclease
MPHLCCUG_RS04285	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MPHLCCUG_RS04290	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
MPHLCCUG_RS04340	COG0246	Mannitol dehydrogenase
MPHLCCUG_RS04345	COG1063	alcohol dehydrogenase
MPHLCCUG_RS04360	COG1175	transmembrane transport
MPHLCCUG_RS04365	COG0395	ABC-type sugar transport system, permease component
MPHLCCUG_RS04370	COG3842	ATPase activity
MPHLCCUG_RS04380	COG3285	dna ligase
MPHLCCUG_RS04380	COG1793	dna ligase
MPHLCCUG_RS04385	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MPHLCCUG_RS04390	COG1024	Enoyl-CoA hydratase
MPHLCCUG_RS04395	COG0328	RNA-DNA hybrid ribonuclease activity
MPHLCCUG_RS04415	COG0745	RESPONSE REGULATOR receiver
MPHLCCUG_RS04420	COG2205	protein histidine kinase activity
MPHLCCUG_RS04465	COG1960	acyl-CoA dehydrogenase activity
MPHLCCUG_RS04485	COG0747	negative chemotaxis
MPHLCCUG_RS04490	COG0747	negative chemotaxis
MPHLCCUG_RS04510	COG0431	NADPH-dependent FMN reductase
MPHLCCUG_RS04515	COG1950	PFAM Membrane protein of
MPHLCCUG_RS04520	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
MPHLCCUG_RS04525	COG1605	Chorismate mutase
MPHLCCUG_RS04560	COG2755	lipolytic protein G-D-S-L family
MPHLCCUG_RS04560	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
MPHLCCUG_RS04580	COG0739	heme binding
MPHLCCUG_RS04585	COG0045	succinate-CoA ligase (ADP-forming) activity
MPHLCCUG_RS04630	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
MPHLCCUG_RS04650	COG1024	Enoyl-CoA hydratase
MPHLCCUG_RS04665	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
MPHLCCUG_RS04670	COG1960	acyl-CoA dehydrogenase activity
MPHLCCUG_RS04695	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MPHLCCUG_RS04700	COG0521	Mo-molybdopterin cofactor biosynthetic process
MPHLCCUG_RS04700	COG0315	cyclic pyranopterin monophosphate synthase activity
MPHLCCUG_RS04725	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
MPHLCCUG_RS04730	COG1210	Utp--glucose-1-phosphate uridylyltransferase
MPHLCCUG_RS04765	COG0604	alcohol dehydrogenase
MPHLCCUG_RS04765	COG1028	Short-chain dehydrogenase reductase Sdr
MPHLCCUG_RS04765	COG3321	synthase
MPHLCCUG_RS04805	COG0778	Nitroreductase
MPHLCCUG_RS04805	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
MPHLCCUG_RS04810	COG1216	Glycosyl transferase, family 2
MPHLCCUG_RS04810	COG1442	glycosyl transferase family 8
MPHLCCUG_RS04830	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
MPHLCCUG_RS04845	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MPHLCCUG_RS04845	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MPHLCCUG_RS04850	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
MPHLCCUG_RS04890	COG2235	arginine
MPHLCCUG_RS04905	COG4221	oxidoreductase activity
MPHLCCUG_RS04935	COG0142	geranyltranstransferase activity
MPHLCCUG_RS04940	COG0501	Belongs to the peptidase M48B family
MPHLCCUG_RS04970	COG1666	GTP binding
MPHLCCUG_RS04995	COG0596	Alpha beta hydrolase
MPHLCCUG_RS05015	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
MPHLCCUG_RS05045	COG1804	L-carnitine dehydratase bile acid-inducible protein F
MPHLCCUG_RS05055	COG2186	Transcriptional regulator
MPHLCCUG_RS05075	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
MPHLCCUG_RS05080	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
MPHLCCUG_RS05095	COG4221	oxidoreductase activity
MPHLCCUG_RS05135	COG0477	Major facilitator Superfamily
MPHLCCUG_RS05155	COG0492	ferredoxin-NADP+ reductase activity
MPHLCCUG_RS05170	COG0477	Major facilitator Superfamily
MPHLCCUG_RS05225	COG0655	NAD(P)H dehydrogenase (quinone) activity
MPHLCCUG_RS05270	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MPHLCCUG_RS05280	COG1201	RNA secondary structure unwinding
MPHLCCUG_RS05325	COG0210	DNA helicase
MPHLCCUG_RS05375	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MPHLCCUG_RS05400	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
MPHLCCUG_RS05425	COG2813	Specifically methylates the guanine in position
MPHLCCUG_RS05460	COG0069	glutamate synthase activity
MPHLCCUG_RS05470	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
MPHLCCUG_RS05480	COG0657	acetylesterase activity
MPHLCCUG_RS05495	COG1309	transcriptional regulator
MPHLCCUG_RS05500	COG1028	Short-chain dehydrogenase reductase Sdr
MPHLCCUG_RS05520	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
MPHLCCUG_RS05550	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MPHLCCUG_RS05570	COG0328	RNA-DNA hybrid ribonuclease activity
MPHLCCUG_RS05575	COG2011	ABC-type metal ion transport system permease component
MPHLCCUG_RS05580	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
MPHLCCUG_RS05585	COG1464	Belongs to the NlpA lipoprotein family
MPHLCCUG_RS05605	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MPHLCCUG_RS05610	COG0438	transferase activity, transferring glycosyl groups
MPHLCCUG_RS05630	COG2072	flavoprotein involved in K transport
MPHLCCUG_RS05635	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MPHLCCUG_RS05650	COG1278	Cold shock
MPHLCCUG_RS05670	COG0318	PFAM AMP-dependent synthetase and ligase
MPHLCCUG_RS05685	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MPHLCCUG_RS05705	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MPHLCCUG_RS05710	COG1074	ATP-dependent DNA helicase activity
MPHLCCUG_RS05715	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
MPHLCCUG_RS05730	COG1309	transcriptional regulator
MPHLCCUG_RS05760	COG2197	response regulator
MPHLCCUG_RS05795	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MPHLCCUG_RS05815	COG0267	Belongs to the bacterial ribosomal protein bL33 family
MPHLCCUG_RS05820	COG2030	dehydratase
MPHLCCUG_RS05825	COG2030	dehydratase
MPHLCCUG_RS05840	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
MPHLCCUG_RS05850	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
MPHLCCUG_RS05855	COG0081	regulation of translation
MPHLCCUG_RS05905	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
MPHLCCUG_RS05910	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
MPHLCCUG_RS05980	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
MPHLCCUG_RS05985	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MPHLCCUG_RS05990	COG0736	holo-[acyl-carrier-protein] synthase activity
MPHLCCUG_RS06030	COG2318	DinB family
MPHLCCUG_RS06080	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
MPHLCCUG_RS06095	COG0243	molybdopterin cofactor binding
MPHLCCUG_RS06115	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MPHLCCUG_RS06120	COG4303	Ethanolamine ammonia lyase large subunit
MPHLCCUG_RS06145	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
MPHLCCUG_RS06165	COG1960	acyl-CoA dehydrogenase activity
MPHLCCUG_RS06180	COG1024	Enoyl-CoA hydratase
MPHLCCUG_RS06205	COG1309	transcriptional regulator
MPHLCCUG_RS06215	COG0049	tRNA binding
MPHLCCUG_RS06225	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MPHLCCUG_RS06245	COG2235	arginine
MPHLCCUG_RS06260	COG0531	amino acid
MPHLCCUG_RS06265	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MPHLCCUG_RS06270	COG1834	amidinotransferase
MPHLCCUG_RS06275	COG1522	sequence-specific DNA binding
MPHLCCUG_RS06295	COG0281	malic enzyme
MPHLCCUG_RS06305	COG0535	radical SAM domain protein
MPHLCCUG_RS06335	COG0477	Major facilitator Superfamily
MPHLCCUG_RS06355	COG2272	Belongs to the type-B carboxylesterase lipase family
MPHLCCUG_RS06360	COG0051	transcription antitermination factor activity, RNA binding
MPHLCCUG_RS06365	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
MPHLCCUG_RS06375	COG0089	rRNA binding
MPHLCCUG_RS06380	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
MPHLCCUG_RS06385	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
MPHLCCUG_RS06390	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
MPHLCCUG_RS06395	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
MPHLCCUG_RS06400	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
MPHLCCUG_RS06405	COG0255	Belongs to the universal ribosomal protein uL29 family
MPHLCCUG_RS06410	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
MPHLCCUG_RS06440	COG1262	PFAM Formylglycine-generating sulfatase enzyme
MPHLCCUG_RS06445	COG3619	membrane
MPHLCCUG_RS06450	COG3069	C4-dicarboxylate transmembrane transporter activity
MPHLCCUG_RS06485	COG1012	belongs to the aldehyde dehydrogenase family
MPHLCCUG_RS06495	COG0405	Gamma-glutamyltransferase
MPHLCCUG_RS06505	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
MPHLCCUG_RS06510	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
MPHLCCUG_RS06525	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
MPHLCCUG_RS06530	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
MPHLCCUG_RS06535	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
MPHLCCUG_RS06540	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
MPHLCCUG_RS06545	COG1841	ribosomal large subunit assembly
MPHLCCUG_RS06550	COG0200	Binds to the 23S rRNA
MPHLCCUG_RS06565	COG0477	Major facilitator Superfamily
MPHLCCUG_RS06570	COG1473	amidohydrolase
MPHLCCUG_RS06580	COG0616	signal peptide processing
MPHLCCUG_RS06600	COG0563	adenylate kinase activity
MPHLCCUG_RS06630	COG2197	response regulator
MPHLCCUG_RS06645	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
MPHLCCUG_RS06655	COG1960	acyl-CoA dehydrogenase activity
MPHLCCUG_RS06675	COG1113	amino acid transport
MPHLCCUG_RS06680	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
MPHLCCUG_RS06685	COG1088	dTDP-glucose 4,6-dehydratase activity
MPHLCCUG_RS06705	COG3634	alkyl hydroperoxide reductase activity
MPHLCCUG_RS06710	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
MPHLCCUG_RS06715	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
MPHLCCUG_RS06725	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
MPHLCCUG_RS06730	COG0202	RNA polymerase activity
MPHLCCUG_RS06735	COG0203	ribosomal protein L17
MPHLCCUG_RS06770	COG3268	Saccharopine dehydrogenase
MPHLCCUG_RS06800	COG0142	geranyltranstransferase activity
MPHLCCUG_RS06810	COG1404	Belongs to the peptidase S8 family
MPHLCCUG_RS06820	COG1674	ftsk spoiiie
MPHLCCUG_RS06830	COG4842	Belongs to the WXG100 family
MPHLCCUG_RS06835	COG4842	Belongs to the WXG100 family
MPHLCCUG_RS06840	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
MPHLCCUG_RS06870	COG0513	Belongs to the DEAD box helicase family
MPHLCCUG_RS06875	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MPHLCCUG_RS06885	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
MPHLCCUG_RS06890	COG0596	Alpha beta hydrolase
MPHLCCUG_RS06900	COG5285	phytanoyl-CoA dioxygenase
MPHLCCUG_RS06905	COG1917	Cupin 2, conserved barrel domain protein
MPHLCCUG_RS06910	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
MPHLCCUG_RS06930	COG3842	ATPase activity
MPHLCCUG_RS06935	COG0395	ABC-type sugar transport system, permease component
MPHLCCUG_RS06950	COG1028	Short-chain dehydrogenase reductase Sdr
MPHLCCUG_RS06955	COG1070	Carbohydrate kinase
MPHLCCUG_RS06960	COG0434	BtpA family
MPHLCCUG_RS06965	COG0483	inositol monophosphate 1-phosphatase activity
MPHLCCUG_RS06970	COG1349	DNA-binding transcription factor activity
MPHLCCUG_RS06980	COG0076	glutamate decarboxylase activity
MPHLCCUG_RS06985	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
MPHLCCUG_RS07005	COG0456	acetyltransferase
MPHLCCUG_RS07010	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
MPHLCCUG_RS07020	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
MPHLCCUG_RS07055	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
MPHLCCUG_RS07095	COG0516	GMP reductase activity
MPHLCCUG_RS07125	COG0519	Catalyzes the synthesis of GMP from XMP
MPHLCCUG_RS07125	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MPHLCCUG_RS07145	COG4221	oxidoreductase activity
MPHLCCUG_RS07165	COG0587	DNA-directed DNA polymerase activity
MPHLCCUG_RS07190	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
MPHLCCUG_RS07205	COG2205	protein histidine kinase activity
MPHLCCUG_RS07210	COG2018	Roadblock/LC7 domain
MPHLCCUG_RS07225	COG1357	PFAM Pentapeptide repeats (8 copies)
MPHLCCUG_RS07230	COG1959	2 iron, 2 sulfur cluster binding
MPHLCCUG_RS07245	COG0842	Transport permease protein
MPHLCCUG_RS07245	COG1716	ATPase activity
MPHLCCUG_RS07245	COG1131	(ABC) transporter
MPHLCCUG_RS07260	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
MPHLCCUG_RS07280	COG2873	o-acetylhomoserine
MPHLCCUG_RS07305	COG1295	ribonuclease BN
MPHLCCUG_RS07310	COG2076	Multidrug Resistance protein
MPHLCCUG_RS07315	COG2070	2-Nitropropane dioxygenase
MPHLCCUG_RS07320	COG1686	Belongs to the peptidase S11 family
MPHLCCUG_RS07330	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
MPHLCCUG_RS07355	COG1595	DNA-templated transcription, initiation
MPHLCCUG_RS07360	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
MPHLCCUG_RS07370	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
MPHLCCUG_RS07375	COG1053	succinate dehydrogenase
MPHLCCUG_RS07385	COG2009	succinate dehydrogenase
MPHLCCUG_RS07400	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
MPHLCCUG_RS07410	COG0741	lytic transglycosylase activity
MPHLCCUG_RS07410	COG0791	NLP P60 protein
MPHLCCUG_RS07425	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MPHLCCUG_RS07430	COG1846	Transcriptional regulator
MPHLCCUG_RS07435	COG3180	Ammonia monooxygenase
MPHLCCUG_RS07450	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
MPHLCCUG_RS07450	COG1473	amidohydrolase
MPHLCCUG_RS07470	COG0564	pseudouridine synthase activity
MPHLCCUG_RS07490	COG1028	Short-chain dehydrogenase reductase Sdr
MPHLCCUG_RS07500	COG1309	transcriptional regulator
MPHLCCUG_RS07535	COG1201	RNA secondary structure unwinding
MPHLCCUG_RS07540	COG1309	transcriptional regulator
MPHLCCUG_RS07545	COG1690	Belongs to the RtcB family
MPHLCCUG_RS07550	COG1028	Short-chain dehydrogenase reductase Sdr
MPHLCCUG_RS07555	COG2017	converts alpha-aldose to the beta-anomer
MPHLCCUG_RS07575	COG4214	carbohydrate transport
MPHLCCUG_RS07590	COG1879	ABC-type sugar transport system periplasmic component
MPHLCCUG_RS07600	COG1172	Belongs to the binding-protein-dependent transport system permease family
MPHLCCUG_RS07605	COG1172	Belongs to the binding-protein-dependent transport system permease family
MPHLCCUG_RS07610	COG1609	Transcriptional regulator
MPHLCCUG_RS07625	COG2160	L-arabinose isomerase activity
MPHLCCUG_RS07630	COG1063	alcohol dehydrogenase
MPHLCCUG_RS07640	COG1529	Aldehyde oxidase and xanthine dehydrogenase
MPHLCCUG_RS07660	COG1012	belongs to the aldehyde dehydrogenase family
MPHLCCUG_RS07670	COG1522	sequence-specific DNA binding
MPHLCCUG_RS07730	COG4770	biotin carboxylase activity
MPHLCCUG_RS07755	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
MPHLCCUG_RS07760	COG1088	dTDP-glucose 4,6-dehydratase activity
MPHLCCUG_RS07770	COG0424	maF-like protein
MPHLCCUG_RS07780	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
MPHLCCUG_RS07830	COG0489	protein tyrosine kinase activity
MPHLCCUG_RS07870	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
MPHLCCUG_RS07905	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
MPHLCCUG_RS07925	COG1316	TRANSCRIPTIONal
MPHLCCUG_RS07930	COG1091	dTDP-4-dehydrorhamnose reductase activity
MPHLCCUG_RS07950	COG0778	Nitroreductase
MPHLCCUG_RS07950	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
MPHLCCUG_RS07975	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MPHLCCUG_RS07990	COG2354	Protein conserved in bacteria
MPHLCCUG_RS07995	COG0531	amino acid
MPHLCCUG_RS08000	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MPHLCCUG_RS08065	COG0745	RESPONSE REGULATOR receiver
MPHLCCUG_RS08070	COG5002	protein histidine kinase activity
MPHLCCUG_RS08075	COG5401	PFAM Sporulation and spore germination
MPHLCCUG_RS08080	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
MPHLCCUG_RS08085	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
MPHLCCUG_RS08090	COG0653	protein targeting
MPHLCCUG_RS08110	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
MPHLCCUG_RS08135	COG2814	Major facilitator Superfamily
MPHLCCUG_RS08140	COG1162	GTPase activity
MPHLCCUG_RS08150	COG2135	peptidase activity
MPHLCCUG_RS08160	COG1309	transcriptional regulator
MPHLCCUG_RS08185	COG1028	Short-chain dehydrogenase reductase Sdr
MPHLCCUG_RS08195	COG1595	DNA-templated transcription, initiation
MPHLCCUG_RS08200	COG5662	AntiSigma factor
MPHLCCUG_RS08205	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
MPHLCCUG_RS08220	COG1597	lipid kinase activity
MPHLCCUG_RS08240	COG0406	alpha-ribazole phosphatase activity
MPHLCCUG_RS08255	COG0513	Belongs to the DEAD box helicase family
MPHLCCUG_RS08300	COG0596	Alpha beta hydrolase
MPHLCCUG_RS08310	COG0210	DNA helicase
MPHLCCUG_RS08345	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
MPHLCCUG_RS08360	COG3480	Lon protease (S16) C-terminal proteolytic domain
MPHLCCUG_RS08365	COG1615	UPF0182 protein
MPHLCCUG_RS08370	COG3629	intracellular signal transduction
MPHLCCUG_RS08400	COG2272	Belongs to the type-B carboxylesterase lipase family
MPHLCCUG_RS08430	COG0318	PFAM AMP-dependent synthetase and ligase
MPHLCCUG_RS08445	COG0596	Alpha beta hydrolase
MPHLCCUG_RS08460	COG2072	flavoprotein involved in K transport
MPHLCCUG_RS08480	COG1024	Enoyl-CoA hydratase
MPHLCCUG_RS08485	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MPHLCCUG_RS08510	COG0713	ATP synthesis coupled electron transport
MPHLCCUG_RS08520	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MPHLCCUG_RS08530	COG1034	ATP synthesis coupled electron transport
MPHLCCUG_RS08545	COG0649	NAD binding
MPHLCCUG_RS08550	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MPHLCCUG_RS08555	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MPHLCCUG_RS08580	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MPHLCCUG_RS08605	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MPHLCCUG_RS08610	COG1804	L-carnitine dehydratase bile acid-inducible protein F
MPHLCCUG_RS08640	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
MPHLCCUG_RS08645	COG0604	alcohol dehydrogenase
MPHLCCUG_RS08650	COG1960	acyl-CoA dehydrogenase activity
MPHLCCUG_RS08660	COG0483	inositol monophosphate 1-phosphatase activity
MPHLCCUG_RS08670	COG0493	'glutamate synthase
MPHLCCUG_RS08675	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
MPHLCCUG_RS08680	COG0668	transmembrane transport
MPHLCCUG_RS08690	COG2884	Cell division ATP-binding protein ftsE
MPHLCCUG_RS08695	COG2177	Part of the ABC transporter FtsEX involved in
MPHLCCUG_RS08700	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
MPHLCCUG_RS08725	COG2801	Transposase and inactivated derivatives
MPHLCCUG_RS08730	COG2826	transposase and inactivated derivatives, IS30 family
MPHLCCUG_RS08735	COG2801	Transposase and inactivated derivatives
MPHLCCUG_RS08740	COG2963	transposase activity
MPHLCCUG_RS08775	COG3757	hydrolase, family 25
MPHLCCUG_RS08805	COG1028	Short-chain dehydrogenase reductase Sdr
MPHLCCUG_RS08825	COG1309	transcriptional regulator
MPHLCCUG_RS08830	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MPHLCCUG_RS08835	COG1960	acyl-CoA dehydrogenase activity
MPHLCCUG_RS08855	COG4638	Rieske (2fe-2S)
MPHLCCUG_RS08915	COG1309	transcriptional regulator
MPHLCCUG_RS08925	COG1131	(ABC) transporter
MPHLCCUG_RS08925	COG1716	ATPase activity
MPHLCCUG_RS08925	COG0842	Transport permease protein
MPHLCCUG_RS08935	COG4638	Rieske (2fe-2S)
MPHLCCUG_RS08975	COG1309	transcriptional regulator
MPHLCCUG_RS09015	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MPHLCCUG_RS09025	COG2814	Major facilitator Superfamily
MPHLCCUG_RS09065	COG0545	Peptidyl-prolyl cis-trans isomerase
MPHLCCUG_RS09070	COG1268	BioY protein
MPHLCCUG_RS09075	COG1122	ATPase activity
MPHLCCUG_RS09090	COG2826	transposase and inactivated derivatives, IS30 family
MPHLCCUG_RS09100	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MPHLCCUG_RS09165	COG0589	response to stress
MPHLCCUG_RS09175	COG1960	acyl-CoA dehydrogenase activity
MPHLCCUG_RS09180	COG1960	acyl-CoA dehydrogenase activity
MPHLCCUG_RS09230	COG1028	Short-chain dehydrogenase reductase Sdr
MPHLCCUG_RS09235	COG1960	acyl-CoA dehydrogenase activity
MPHLCCUG_RS09245	COG1960	acyl-CoA dehydrogenase activity
MPHLCCUG_RS09255	COG0318	PFAM AMP-dependent synthetase and ligase
MPHLCCUG_RS09270	COG1024	Enoyl-CoA hydratase
MPHLCCUG_RS09275	COG1024	Enoyl-CoA hydratase
MPHLCCUG_RS09280	COG1024	Enoyl-CoA hydratase
MPHLCCUG_RS09295	COG1024	Enoyl-CoA hydratase
MPHLCCUG_RS09310	COG0300	oxidoreductase activity
MPHLCCUG_RS09315	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MPHLCCUG_RS09320	COG1024	Enoyl-CoA hydratase
MPHLCCUG_RS09345	COG1960	acyl-CoA dehydrogenase activity
MPHLCCUG_RS09365	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
MPHLCCUG_RS09370	COG1028	Short-chain dehydrogenase reductase Sdr
MPHLCCUG_RS09380	COG0183	Belongs to the thiolase family
MPHLCCUG_RS09385	COG0243	molybdopterin cofactor binding
MPHLCCUG_RS09410	COG1012	belongs to the aldehyde dehydrogenase family
MPHLCCUG_RS09415	COG0318	PFAM AMP-dependent synthetase and ligase
MPHLCCUG_RS09430	COG2072	flavoprotein involved in K transport
MPHLCCUG_RS09455	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
MPHLCCUG_RS09470	COG0477	Major facilitator Superfamily
MPHLCCUG_RS09540	COG0431	NADPH-dependent FMN reductase
MPHLCCUG_RS09555	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MPHLCCUG_RS09590	COG2226	methyltransferase
MPHLCCUG_RS09610	COG1309	transcriptional regulator
MPHLCCUG_RS09640	COG2197	response regulator
MPHLCCUG_RS09650	COG1064	alcohol dehydrogenase
MPHLCCUG_RS09660	COG1309	transcriptional regulator
MPHLCCUG_RS09670	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MPHLCCUG_RS09675	COG0601	transmembrane transport
MPHLCCUG_RS09695	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MPHLCCUG_RS09705	COG0560	Phosphoserine phosphatase
MPHLCCUG_RS09705	COG3830	Belongs to the UPF0237 family
MPHLCCUG_RS09710	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MPHLCCUG_RS09715	COG2364	Membrane
MPHLCCUG_RS09720	COG1119	ATPase activity
MPHLCCUG_RS09760	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
MPHLCCUG_RS09765	COG4804	nuclease activity
MPHLCCUG_RS09775	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
MPHLCCUG_RS09800	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MPHLCCUG_RS09805	COG0110	maltose O-acetyltransferase activity
MPHLCCUG_RS09820	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MPHLCCUG_RS09830	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
MPHLCCUG_RS09850	COG0482	sulfurtransferase activity
MPHLCCUG_RS09880	COG0318	PFAM AMP-dependent synthetase and ligase
MPHLCCUG_RS09890	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
MPHLCCUG_RS09905	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MPHLCCUG_RS09910	COG0154	amidase activity
MPHLCCUG_RS09925	COG1309	transcriptional regulator
MPHLCCUG_RS09930	COG1028	Short-chain dehydrogenase reductase Sdr
MPHLCCUG_RS09960	COG0440	acetolactate synthase activity
MPHLCCUG_RS09980	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
MPHLCCUG_RS09990	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
MPHLCCUG_RS09995	COG4106	trans-aconitate 2-methyltransferase activity
MPHLCCUG_RS10020	COG0142	geranyltranstransferase activity
MPHLCCUG_RS10035	COG0473	3-isopropylmalate dehydrogenase activity
MPHLCCUG_RS10040	COG2271	Major facilitator Superfamily
MPHLCCUG_RS10045	COG0179	Fumarylacetoacetate (FAA) hydrolase
MPHLCCUG_RS10050	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MPHLCCUG_RS10070	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
MPHLCCUG_RS10085	COG0494	nUDIX hydrolase
MPHLCCUG_RS10085	COG0406	alpha-ribazole phosphatase activity
MPHLCCUG_RS10090	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
MPHLCCUG_RS10095	COG1920	GTP binding
MPHLCCUG_RS10105	COG0626	cystathionine gamma-synthase activity
MPHLCCUG_RS10110	COG1181	Belongs to the D-alanine--D-alanine ligase family
MPHLCCUG_RS10130	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
MPHLCCUG_RS10140	COG0024	Methionine aminopeptidase
MPHLCCUG_RS10155	COG1461	Dihydroxyacetone kinase
MPHLCCUG_RS10160	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
MPHLCCUG_RS10175	COG0656	L-ascorbic acid biosynthetic process
MPHLCCUG_RS10180	COG0657	acetylesterase activity
MPHLCCUG_RS10195	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
MPHLCCUG_RS10200	COG0742	ribosomal rna small subunit methyltransferase
MPHLCCUG_RS10205	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
MPHLCCUG_RS10225	COG0571	ribonuclease III activity
MPHLCCUG_RS10240	COG1254	Belongs to the acylphosphatase family
MPHLCCUG_RS10265	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
MPHLCCUG_RS10280	COG3547	Transposase (IS116 IS110 IS902 family)
MPHLCCUG_RS10285	COG1686	Belongs to the peptidase S11 family
MPHLCCUG_RS10290	COG1686	Belongs to the peptidase S11 family
MPHLCCUG_RS10300	COG2239	Acts as a magnesium transporter
MPHLCCUG_RS10310	COG0228	four-way junction DNA binding
MPHLCCUG_RS10320	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
MPHLCCUG_RS10375	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
MPHLCCUG_RS10395	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
MPHLCCUG_RS10410	COG1309	transcriptional regulator
MPHLCCUG_RS10415	COG2124	cytochrome p450
MPHLCCUG_RS10425	COG0714	Associated with various cellular activities
MPHLCCUG_RS10440	COG1028	Short-chain dehydrogenase reductase Sdr
MPHLCCUG_RS10450	COG2124	cytochrome p450
MPHLCCUG_RS10460	COG1028	Short-chain dehydrogenase reductase Sdr
MPHLCCUG_RS10470	COG1804	L-carnitine dehydratase bile acid-inducible protein F
MPHLCCUG_RS10480	COG0318	PFAM AMP-dependent synthetase and ligase
MPHLCCUG_RS10485	COG3842	ATPase activity
MPHLCCUG_RS10505	COG2801	Transposase and inactivated derivatives
MPHLCCUG_RS10505	COG3415	Transposase
MPHLCCUG_RS10555	COG4974	Belongs to the 'phage' integrase family
MPHLCCUG_RS10560	COG2267	carboxylic ester hydrolase activity
MPHLCCUG_RS10575	COG0052	Belongs to the universal ribosomal protein uS2 family
MPHLCCUG_RS10580	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
MPHLCCUG_RS10585	COG0154	amidase activity
MPHLCCUG_RS10600	COG1136	(ABC) transporter
MPHLCCUG_RS10615	COG1929	Belongs to the glycerate kinase type-1 family
MPHLCCUG_RS10665	COG1804	L-carnitine dehydratase bile acid-inducible protein F
MPHLCCUG_RS10685	COG2801	Transposase and inactivated derivatives
MPHLCCUG_RS10685	COG3415	Transposase
MPHLCCUG_RS10705	COG2124	cytochrome p450
MPHLCCUG_RS10710	COG1063	alcohol dehydrogenase
MPHLCCUG_RS10730	COG0657	acetylesterase activity
MPHLCCUG_RS10750	COG1960	acyl-CoA dehydrogenase activity
MPHLCCUG_RS10755	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MPHLCCUG_RS10785	COG0415	Belongs to the DNA photolyase family
MPHLCCUG_RS10800	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
MPHLCCUG_RS10805	COG0750	zinc metalloprotease
MPHLCCUG_RS10855	COG2918	glutathione biosynthetic process
MPHLCCUG_RS10855	COG0189	ligase activity
MPHLCCUG_RS10860	COG0367	asparagine synthase
MPHLCCUG_RS10875	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
MPHLCCUG_RS10880	COG1012	belongs to the aldehyde dehydrogenase family
MPHLCCUG_RS10885	COG1028	Short-chain dehydrogenase reductase Sdr
MPHLCCUG_RS10890	COG2186	Transcriptional regulator
MPHLCCUG_RS10895	COG1403	HNH endonuclease
MPHLCCUG_RS10910	COG1842	Phage shock protein A
MPHLCCUG_RS10915	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
MPHLCCUG_RS10915	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
MPHLCCUG_RS10930	COG0291	Belongs to the bacterial ribosomal protein bL35 family
MPHLCCUG_RS10935	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
MPHLCCUG_RS10940	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MPHLCCUG_RS10945	COG1960	acyl-CoA dehydrogenase activity
MPHLCCUG_RS10960	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
MPHLCCUG_RS10980	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
MPHLCCUG_RS10985	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MPHLCCUG_RS10990	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
MPHLCCUG_RS11000	COG0137	argininosuccinate synthase activity
MPHLCCUG_RS11005	COG0165	Argininosuccinate lyase
MPHLCCUG_RS11015	COG0488	(ABC) transporter
MPHLCCUG_RS11025	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
MPHLCCUG_RS11035	COG2188	Transcriptional regulator
MPHLCCUG_RS11050	COG3626	phosphonate metabolism
MPHLCCUG_RS11055	COG3627	carbon phosphorus lyase activity
MPHLCCUG_RS11060	COG4107	phosphonate C-P lyase system protein PhnK
MPHLCCUG_RS11075	COG0318	PFAM AMP-dependent synthetase and ligase
MPHLCCUG_RS11085	COG2835	tetraacyldisaccharide 4'-kinase activity
MPHLCCUG_RS11120	COG0647	UMP catabolic process
MPHLCCUG_RS11135	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
MPHLCCUG_RS11160	COG0494	nUDIX hydrolase
MPHLCCUG_RS11195	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
MPHLCCUG_RS11200	COG1160	GTP binding
MPHLCCUG_RS11275	COG1028	Short-chain dehydrogenase reductase Sdr
MPHLCCUG_RS11305	COG0300	oxidoreductase activity
MPHLCCUG_RS11435	COG2076	Multidrug Resistance protein
MPHLCCUG_RS11445	COG2272	Belongs to the type-B carboxylesterase lipase family
MPHLCCUG_RS11455	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MPHLCCUG_RS11475	COG0640	Transcriptional regulator
MPHLCCUG_RS11525	COG0509	glycine decarboxylation via glycine cleavage system
MPHLCCUG_RS11530	COG1716	ATPase activity
MPHLCCUG_RS11550	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MPHLCCUG_RS11550	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MPHLCCUG_RS11575	COG1253	flavin adenine dinucleotide binding
MPHLCCUG_RS11580	COG1253	flavin adenine dinucleotide binding
MPHLCCUG_RS11590	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
MPHLCCUG_RS11630	COG0804	urea catabolic process
MPHLCCUG_RS11640	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
MPHLCCUG_RS11645	COG0829	nickel cation binding
MPHLCCUG_RS11650	COG1252	NADH dehydrogenase
MPHLCCUG_RS11655	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MPHLCCUG_RS11705	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
MPHLCCUG_RS11710	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MPHLCCUG_RS11715	COG0183	Belongs to the thiolase family
MPHLCCUG_RS11735	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MPHLCCUG_RS11745	COG0668	transmembrane transport
MPHLCCUG_RS11790	COG1289	transmembrane transporter activity
MPHLCCUG_RS11815	COG1024	Enoyl-CoA hydratase
MPHLCCUG_RS11845	COG0174	glutamine synthetase
MPHLCCUG_RS11855	COG4308	Limonene-1,2-epoxide hydrolase catalytic domain
MPHLCCUG_RS11875	COG0745	RESPONSE REGULATOR receiver
MPHLCCUG_RS11880	COG1464	Belongs to the NlpA lipoprotein family
MPHLCCUG_RS11905	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MPHLCCUG_RS11930	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MPHLCCUG_RS11935	COG3874	Sporulation protein YtfJ
MPHLCCUG_RS11945	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
MPHLCCUG_RS11955	COG2271	Major facilitator Superfamily
MPHLCCUG_RS11965	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
MPHLCCUG_RS11985	COG1376	ErfK ybiS ycfS ynhG family protein
MPHLCCUG_RS12045	COG2070	2-Nitropropane dioxygenase
MPHLCCUG_RS12065	COG1058	Belongs to the CinA family
MPHLCCUG_RS12065	COG1546	Belongs to the CinA family
MPHLCCUG_RS12095	COG0318	PFAM AMP-dependent synthetase and ligase
MPHLCCUG_RS12105	COG3022	response to hydroperoxide
MPHLCCUG_RS12170	COG2755	lipolytic protein G-D-S-L family
MPHLCCUG_RS12185	COG0579	oxidoreductase
MPHLCCUG_RS12190	COG3883	PFAM NLP P60 protein
MPHLCCUG_RS12190	COG0791	NLP P60 protein
MPHLCCUG_RS12205	COG0318	PFAM AMP-dependent synthetase and ligase
MPHLCCUG_RS12225	COG1234	tRNA 3'-trailer cleavage
MPHLCCUG_RS12235	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MPHLCCUG_RS12255	COG0010	Belongs to the arginase family
MPHLCCUG_RS12270	COG1028	Short-chain dehydrogenase reductase Sdr
MPHLCCUG_RS12280	COG0545	Peptidyl-prolyl cis-trans isomerase
MPHLCCUG_RS12285	COG0300	oxidoreductase activity
MPHLCCUG_RS12295	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MPHLCCUG_RS12310	COG3757	hydrolase, family 25
MPHLCCUG_RS12320	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MPHLCCUG_RS12325	COG0187	DNA topoisomerase II activity
MPHLCCUG_RS12355	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
MPHLCCUG_RS12370	COG0697	spore germination
MPHLCCUG_RS12390	COG1028	Short-chain dehydrogenase reductase Sdr
MPHLCCUG_RS12405	COG1960	acyl-CoA dehydrogenase activity
MPHLCCUG_RS12415	COG1024	Enoyl-CoA hydratase
MPHLCCUG_RS12420	COG0028	Belongs to the TPP enzyme family
MPHLCCUG_RS12430	COG1012	belongs to the aldehyde dehydrogenase family
MPHLCCUG_RS12450	COG0667	Aldo Keto reductase
MPHLCCUG_RS12510	COG1125	glycine betaine transport
MPHLCCUG_RS12510	COG0517	IMP dehydrogenase activity
MPHLCCUG_RS12515	COG1174	glycine betaine transport
MPHLCCUG_RS12545	COG1228	amidohydrolase
MPHLCCUG_RS12550	COG0815	Transfers the fatty acyl group on membrane lipoproteins
MPHLCCUG_RS12555	COG0463	Glycosyl transferase, family 2
MPHLCCUG_RS12575	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MPHLCCUG_RS12585	COG2272	Belongs to the type-B carboxylesterase lipase family
MPHLCCUG_RS12595	COG3547	Transposase (IS116 IS110 IS902 family)
MPHLCCUG_RS12600	COG1742	UPF0060 membrane protein
MPHLCCUG_RS12610	COG1802	Transcriptional regulator
MPHLCCUG_RS12615	COG3265	gluconokinase activity
MPHLCCUG_RS12620	COG2610	gluconate transmembrane transporter activity
MPHLCCUG_RS12640	COG1070	Carbohydrate kinase
MPHLCCUG_RS12650	COG1070	Carbohydrate kinase
MPHLCCUG_RS12665	COG1063	alcohol dehydrogenase
MPHLCCUG_RS12670	COG1653	transport
MPHLCCUG_RS12675	COG1175	transmembrane transport
MPHLCCUG_RS12685	COG3842	ATPase activity
MPHLCCUG_RS12690	COG3842	ATPase activity
MPHLCCUG_RS12695	COG2376	Dihydroxyacetone kinase
MPHLCCUG_RS12700	COG0698	ribose 5-phosphate isomerase
MPHLCCUG_RS12705	COG1129	ABC transporter
MPHLCCUG_RS12710	COG1172	Belongs to the binding-protein-dependent transport system permease family
MPHLCCUG_RS12715	COG1879	ABC-type sugar transport system periplasmic component
MPHLCCUG_RS12720	COG1028	Short-chain dehydrogenase reductase Sdr
MPHLCCUG_RS12735	COG1053	succinate dehydrogenase
MPHLCCUG_RS12770	COG0657	acetylesterase activity
MPHLCCUG_RS12790	COG1960	acyl-CoA dehydrogenase activity
MPHLCCUG_RS12795	COG1024	Enoyl-CoA hydratase
MPHLCCUG_RS12805	COG1063	alcohol dehydrogenase
MPHLCCUG_RS12810	COG0318	PFAM AMP-dependent synthetase and ligase
MPHLCCUG_RS12815	COG2072	flavoprotein involved in K transport
MPHLCCUG_RS12840	COG1053	succinate dehydrogenase
MPHLCCUG_RS12850	COG1414	Transcriptional regulator
MPHLCCUG_RS12855	COG0346	lactoylglutathione lyase activity
MPHLCCUG_RS12865	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
MPHLCCUG_RS12870	COG2072	flavoprotein involved in K transport
MPHLCCUG_RS12880	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
MPHLCCUG_RS12885	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
MPHLCCUG_RS12910	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
MPHLCCUG_RS12925	COG0477	Major facilitator Superfamily
MPHLCCUG_RS12950	COG1177	transmembrane transport
MPHLCCUG_RS12955	COG1176	ABC-type spermidine putrescine transport system, permease component I
MPHLCCUG_RS12965	COG3842	ATPase activity
MPHLCCUG_RS13035	COG1063	alcohol dehydrogenase
MPHLCCUG_RS13045	COG2072	flavoprotein involved in K transport
MPHLCCUG_RS13050	COG1309	transcriptional regulator
MPHLCCUG_RS13070	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
MPHLCCUG_RS13090	COG0227	Belongs to the bacterial ribosomal protein bL28 family
MPHLCCUG_RS13095	COG0267	Belongs to the bacterial ribosomal protein bL33 family
MPHLCCUG_RS13100	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
MPHLCCUG_RS13105	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
MPHLCCUG_RS13115	COG1120	ATPase activity
MPHLCCUG_RS13140	COG2801	Transposase and inactivated derivatives
MPHLCCUG_RS13165	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MPHLCCUG_RS13170	COG1121	(ABC) transporter
MPHLCCUG_RS13235	COG0300	oxidoreductase activity
MPHLCCUG_RS13245	COG2801	Transposase and inactivated derivatives
MPHLCCUG_RS13245	COG3415	Transposase
MPHLCCUG_RS13275	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MPHLCCUG_RS13280	COG2378	regulation of single-species biofilm formation
MPHLCCUG_RS13290	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
MPHLCCUG_RS13305	COG2267	carboxylic ester hydrolase activity
MPHLCCUG_RS13310	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
MPHLCCUG_RS13315	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
MPHLCCUG_RS13325	COG4122	O-methyltransferase activity
MPHLCCUG_RS13340	COG3226	Transcriptional regulator
MPHLCCUG_RS13355	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
MPHLCCUG_RS13360	COG1222	aaa ATPase
MPHLCCUG_RS13395	COG3706	GGDEF domain
MPHLCCUG_RS13405	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MPHLCCUG_RS13410	COG1028	Short-chain dehydrogenase reductase Sdr
MPHLCCUG_RS13415	COG3588	fructose-bisphosphate aldolase
MPHLCCUG_RS13450	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MPHLCCUG_RS13480	COG0539	negative regulation of cytoplasmic translation
MPHLCCUG_RS13515	COG0596	Alpha beta hydrolase
MPHLCCUG_RS13525	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MPHLCCUG_RS13530	COG1872	DUF167
MPHLCCUG_RS13535	COG0410	ABC transporter
MPHLCCUG_RS13585	COG0783	Belongs to the Dps family
MPHLCCUG_RS13595	COG2197	response regulator
MPHLCCUG_RS13615	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MPHLCCUG_RS13630	COG1271	oxidase subunit
MPHLCCUG_RS13635	COG1294	oxidase, subunit
MPHLCCUG_RS13640	COG4988	ABC transporter
MPHLCCUG_RS13645	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
MPHLCCUG_RS13670	COG0070	glutamate synthase
MPHLCCUG_RS13670	COG0069	glutamate synthase activity
MPHLCCUG_RS13670	COG0067	glutamate synthase
MPHLCCUG_RS13705	COG0134	indole-3-glycerol-phosphate synthase activity
MPHLCCUG_RS13715	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MPHLCCUG_RS13725	COG1119	ATPase activity
MPHLCCUG_RS13730	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
MPHLCCUG_RS13735	COG0107	imidazoleglycerol-phosphate synthase activity
MPHLCCUG_RS13740	COG0483	inositol monophosphate 1-phosphatase activity
MPHLCCUG_RS13745	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
MPHLCCUG_RS13750	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
MPHLCCUG_RS13755	COG0131	Imidazoleglycerol-phosphate dehydratase
MPHLCCUG_RS13760	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MPHLCCUG_RS13775	COG1309	transcriptional regulator
MPHLCCUG_RS13795	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
MPHLCCUG_RS13820	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
MPHLCCUG_RS13825	COG1309	transcriptional regulator
MPHLCCUG_RS13850	COG0156	8-amino-7-oxononanoate synthase activity
MPHLCCUG_RS13925	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
MPHLCCUG_RS13930	COG0252	asparaginase activity
MPHLCCUG_RS13945	COG2501	S4 domain
MPHLCCUG_RS13950	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
MPHLCCUG_RS13970	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
MPHLCCUG_RS14015	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
MPHLCCUG_RS14020	COG1028	Short-chain dehydrogenase reductase Sdr
MPHLCCUG_RS14025	COG2304	oxidoreductase activity
MPHLCCUG_RS14030	COG2304	oxidoreductase activity
MPHLCCUG_RS14040	COG0714	Associated with various cellular activities
MPHLCCUG_RS14060	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
MPHLCCUG_RS14065	COG1309	transcriptional regulator
MPHLCCUG_RS14075	COG0488	(ABC) transporter
MPHLCCUG_RS14085	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MPHLCCUG_RS14095	COG0477	Major facilitator Superfamily
MPHLCCUG_RS14105	COG2151	metal-sulfur cluster biosynthetic enzyme
MPHLCCUG_RS14110	COG0822	iron-sulfur transferase activity
MPHLCCUG_RS14120	COG0396	ATPase activity
MPHLCCUG_RS14180	COG0109	protoheme IX farnesyltransferase activity
MPHLCCUG_RS14190	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
MPHLCCUG_RS14220	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
MPHLCCUG_RS14230	COG0149	triose-phosphate isomerase activity
MPHLCCUG_RS14235	COG0126	phosphoglycerate kinase activity
MPHLCCUG_RS14240	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MPHLCCUG_RS14250	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
MPHLCCUG_RS14260	COG1481	regulation of sporulation
MPHLCCUG_RS14270	COG1660	Displays ATPase and GTPase activities
MPHLCCUG_RS14285	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
MPHLCCUG_RS14290	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MPHLCCUG_RS14290	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MPHLCCUG_RS14305	COG0477	Major facilitator Superfamily
MPHLCCUG_RS14310	COG0693	protein deglycase activity
MPHLCCUG_RS14330	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
MPHLCCUG_RS14335	COG1704	LemA family
MPHLCCUG_RS14355	COG0657	acetylesterase activity
MPHLCCUG_RS14375	COG1758	RNA polymerase activity
MPHLCCUG_RS14390	COG0284	orotidine-5'-phosphate decarboxylase activity
MPHLCCUG_RS14400	COG0505	Belongs to the CarA family
MPHLCCUG_RS14415	COG0540	Belongs to the ATCase OTCase family
MPHLCCUG_RS14420	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
MPHLCCUG_RS14430	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
MPHLCCUG_RS14455	COG1802	Transcriptional regulator
MPHLCCUG_RS14465	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MPHLCCUG_RS14475	COG0006	proline dipeptidase activity
MPHLCCUG_RS14500	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
MPHLCCUG_RS14515	COG1309	transcriptional regulator
MPHLCCUG_RS14535	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
MPHLCCUG_RS14545	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
MPHLCCUG_RS14550	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MPHLCCUG_RS14555	COG0432	Pfam Uncharacterised protein family UPF0047
MPHLCCUG_RS14620	COG1733	regulation of RNA biosynthetic process
MPHLCCUG_RS14625	COG0183	Belongs to the thiolase family
MPHLCCUG_RS14635	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
MPHLCCUG_RS14650	COG2272	Belongs to the type-B carboxylesterase lipase family
MPHLCCUG_RS14665	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MPHLCCUG_RS14695	COG1960	acyl-CoA dehydrogenase activity
MPHLCCUG_RS14700	COG1960	acyl-CoA dehydrogenase activity
MPHLCCUG_RS14710	COG3973	AAA domain
MPHLCCUG_RS14720	COG0683	leucine binding
MPHLCCUG_RS14735	COG0411	ABC transporter
MPHLCCUG_RS14750	COG0124	histidyl-tRNA synthetase
MPHLCCUG_RS14775	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MPHLCCUG_RS14785	COG0747	negative chemotaxis
MPHLCCUG_RS14790	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MPHLCCUG_RS14810	COG1012	belongs to the aldehyde dehydrogenase family
MPHLCCUG_RS14830	COG1022	Amp-dependent synthetase and ligase
MPHLCCUG_RS14830	COG3320	Male sterility
MPHLCCUG_RS14840	COG2255	four-way junction helicase activity
MPHLCCUG_RS14845	COG0632	four-way junction helicase activity
MPHLCCUG_RS14850	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
MPHLCCUG_RS14860	COG0217	transcriptional regulatory protein
MPHLCCUG_RS14865	COG1960	acyl-CoA dehydrogenase activity
MPHLCCUG_RS14870	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
MPHLCCUG_RS14875	COG1946	Acyl-CoA thioesterase
MPHLCCUG_RS14880	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
MPHLCCUG_RS14890	COG0438	transferase activity, transferring glycosyl groups
MPHLCCUG_RS14895	COG1560	Kdo2-lipid A biosynthetic process
MPHLCCUG_RS14900	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MPHLCCUG_RS14925	COG0667	Aldo Keto reductase
MPHLCCUG_RS14930	COG4762	Protein conserved in bacteria
MPHLCCUG_RS14940	COG1376	ErfK ybiS ycfS ynhG family protein
MPHLCCUG_RS15040	COG3467	pyridoxamine 5'-phosphate
MPHLCCUG_RS15075	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MPHLCCUG_RS15085	COG3253	May function as heme-dependent peroxidase
MPHLCCUG_RS15095	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
MPHLCCUG_RS15105	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
MPHLCCUG_RS15120	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
MPHLCCUG_RS15155	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MPHLCCUG_RS15160	COG0531	amino acid
MPHLCCUG_RS15165	COG0569	domain protein
MPHLCCUG_RS15195	COG0756	dUTP diphosphatase activity
MPHLCCUG_RS15215	COG0483	inositol monophosphate 1-phosphatase activity
MPHLCCUG_RS15315	COG1388	LysM domain
MPHLCCUG_RS15320	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
MPHLCCUG_RS15340	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MPHLCCUG_RS15345	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
MPHLCCUG_RS15350	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
MPHLCCUG_RS15360	COG0697	spore germination
MPHLCCUG_RS15365	COG1196	nuclear chromosome segregation
MPHLCCUG_RS15385	COG1126	abc transporter atp-binding protein
MPHLCCUG_RS15390	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MPHLCCUG_RS15395	COG0765	amino acid transport
MPHLCCUG_RS15400	COG0765	amino acid transport
MPHLCCUG_RS15410	COG2137	regulation of response to DNA damage stimulus
MPHLCCUG_RS15425	COG1819	glycosyl
MPHLCCUG_RS15430	COG4308	Limonene-1,2-epoxide hydrolase catalytic domain
MPHLCCUG_RS15440	COG1842	Phage shock protein A
MPHLCCUG_RS15445	COG1396	sequence-specific DNA binding
MPHLCCUG_RS15450	COG1058	Belongs to the CinA family
MPHLCCUG_RS15450	COG1546	Belongs to the CinA family
MPHLCCUG_RS15460	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
MPHLCCUG_RS15480	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
MPHLCCUG_RS15485	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MPHLCCUG_RS15490	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
MPHLCCUG_RS15500	COG3214	Protein conserved in bacteria
MPHLCCUG_RS15510	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
MPHLCCUG_RS15550	COG1522	sequence-specific DNA binding
MPHLCCUG_RS15555	COG0686	Belongs to the AlaDH PNT family
MPHLCCUG_RS15570	COG1185	polyribonucleotide nucleotidyltransferase activity
MPHLCCUG_RS15575	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
MPHLCCUG_RS15595	COG2977	Belongs to the P-Pant transferase superfamily
MPHLCCUG_RS15630	COG1024	Enoyl-CoA hydratase
MPHLCCUG_RS15665	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
MPHLCCUG_RS15680	COG0481	GTPase activity
MPHLCCUG_RS15690	COG0779	Required for maturation of 30S ribosomal subunits
MPHLCCUG_RS15715	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MPHLCCUG_RS15715	COG1648	precorrin-2 dehydrogenase activity
MPHLCCUG_RS15755	COG1122	ATPase activity
MPHLCCUG_RS15770	COG0310	cobalt ion transport
MPHLCCUG_RS15785	COG0302	gtp cyclohydrolase
MPHLCCUG_RS15805	COG1403	HNH endonuclease
MPHLCCUG_RS15810	COG2186	Transcriptional regulator
MPHLCCUG_RS15825	COG0028	Belongs to the TPP enzyme family
MPHLCCUG_RS15840	COG0640	Transcriptional regulator
MPHLCCUG_RS15850	COG0655	NAD(P)H dehydrogenase (quinone) activity
MPHLCCUG_RS15870	COG0140	phosphoribosyl-ATP diphosphatase activity
MPHLCCUG_RS15875	COG0477	Major facilitator Superfamily
MPHLCCUG_RS15880	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MPHLCCUG_RS15895	COG3842	ATPase activity
MPHLCCUG_RS15900	COG3833	ABC-type maltose transport systems, permease component
MPHLCCUG_RS15905	COG1175	transmembrane transport
MPHLCCUG_RS15920	COG1410	methionine synthase
MPHLCCUG_RS15920	COG0646	methionine synthase
MPHLCCUG_RS15930	COG3547	Transposase (IS116 IS110 IS902 family)
MPHLCCUG_RS15935	COG1028	Short-chain dehydrogenase reductase Sdr
MPHLCCUG_RS15940	COG0215	cysteine-tRNA ligase activity
MPHLCCUG_RS15945	COG1218	3'(2'),5'-bisphosphate nucleotidase
MPHLCCUG_RS15985	COG0167	dihydroorotate dehydrogenase activity
MPHLCCUG_RS15995	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MPHLCCUG_RS16010	COG0129	dihydroxy-acid dehydratase activity
MPHLCCUG_RS16025	COG1309	transcriptional regulator
MPHLCCUG_RS16030	COG0243	molybdopterin cofactor binding
MPHLCCUG_RS16035	COG2223	nitrite transmembrane transporter activity
MPHLCCUG_RS16040	COG0589	response to stress
MPHLCCUG_RS16060	COG3290	protein histidine kinase activity
MPHLCCUG_RS16070	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MPHLCCUG_RS16070	COG0519	Catalyzes the synthesis of GMP from XMP
MPHLCCUG_RS16100	COG1799	cell septum assembly
MPHLCCUG_RS16105	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
MPHLCCUG_RS16115	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
MPHLCCUG_RS16120	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
MPHLCCUG_RS16125	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
MPHLCCUG_RS16140	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
MPHLCCUG_RS16160	COG0768	penicillin binding
MPHLCCUG_RS16170	COG0275	rRNA processing
MPHLCCUG_RS16195	COG0142	geranyltranstransferase activity
MPHLCCUG_RS16215	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
MPHLCCUG_RS16230	COG5650	phosphatidylinositol metabolic process
MPHLCCUG_RS16265	COG0438	transferase activity, transferring glycosyl groups
MPHLCCUG_RS16295	COG1845	cytochrome c oxidase, subunit III
MPHLCCUG_RS16340	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MPHLCCUG_RS16365	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
MPHLCCUG_RS16370	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
MPHLCCUG_RS16375	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MPHLCCUG_RS16405	COG1090	epimerase
MPHLCCUG_RS16410	COG0321	lipoyl(octanoyl) transferase activity
MPHLCCUG_RS16415	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
MPHLCCUG_RS16435	COG0174	glutamine synthetase
MPHLCCUG_RS16440	COG2259	Doxx family
MPHLCCUG_RS16460	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
MPHLCCUG_RS16465	COG0174	glutamine synthetase
MPHLCCUG_RS16490	COG1024	Enoyl-CoA hydratase
MPHLCCUG_RS16505	COG2207	Transcriptional regulator
MPHLCCUG_RS16510	COG0346	lactoylglutathione lyase activity
MPHLCCUG_RS16525	COG1396	sequence-specific DNA binding
MPHLCCUG_RS16620	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
MPHLCCUG_RS16625	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MPHLCCUG_RS16645	COG1028	Short-chain dehydrogenase reductase Sdr
MPHLCCUG_RS16675	COG1846	Transcriptional regulator
MPHLCCUG_RS16690	COG3384	dioxygenase
MPHLCCUG_RS16735	COG0747	negative chemotaxis
MPHLCCUG_RS16740	COG0601	transmembrane transport
MPHLCCUG_RS16750	COG4172	Belongs to the ABC transporter superfamily
MPHLCCUG_RS16755	COG1028	Short-chain dehydrogenase reductase Sdr
MPHLCCUG_RS16760	COG1309	transcriptional regulator
MPHLCCUG_RS16790	COG1960	acyl-CoA dehydrogenase activity
MPHLCCUG_RS16805	COG0004	ammonium transporteR
MPHLCCUG_RS16890	COG2814	Major facilitator Superfamily
MPHLCCUG_RS16935	COG0358	DNA primase activity
MPHLCCUG_RS16940	COG0232	Belongs to the dGTPase family. Type 2 subfamily
MPHLCCUG_RS16950	COG0423	glycine-tRNA ligase activity
MPHLCCUG_RS16975	COG1381	Involved in DNA repair and RecF pathway recombination
MPHLCCUG_RS17020	COG0484	heat shock protein binding
MPHLCCUG_RS17025	COG1420	regulation of RNA biosynthetic process
MPHLCCUG_RS17040	COG0745	RESPONSE REGULATOR receiver
MPHLCCUG_RS17045	COG2205	protein histidine kinase activity
MPHLCCUG_RS17090	COG1132	(ABC) transporter
MPHLCCUG_RS17110	COG1021	2,3-dihydroxybenzoate-AMP ligase
MPHLCCUG_RS17120	COG2197	response regulator
MPHLCCUG_RS17125	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
MPHLCCUG_RS17125	COG1672	PFAM Archaeal ATPase
MPHLCCUG_RS17170	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MPHLCCUG_RS17180	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MPHLCCUG_RS17190	COG1937	Protein conserved in bacteria
MPHLCCUG_RS17200	COG4208	sulfate ABC transporter
MPHLCCUG_RS17210	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
MPHLCCUG_RS17225	COG3387	PFAM Glycoside hydrolase 15-related
MPHLCCUG_RS17240	COG0583	DNA-binding transcription factor activity
MPHLCCUG_RS17300	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
MPHLCCUG_RS17300	COG0617	tRNA 3'-terminal CCA addition
MPHLCCUG_RS17300	COG0517	IMP dehydrogenase activity
MPHLCCUG_RS17315	COG4974	Belongs to the 'phage' integrase family
MPHLCCUG_RS17325	COG0640	Transcriptional regulator
MPHLCCUG_RS17380	COG1234	tRNA 3'-trailer cleavage
MPHLCCUG_RS17385	COG1305	Transglutaminase-like
MPHLCCUG_RS17400	COG0268	Binds directly to 16S ribosomal RNA
MPHLCCUG_RS17425	COG1028	Short-chain dehydrogenase reductase Sdr
MPHLCCUG_RS17440	COG2755	lipolytic protein G-D-S-L family
MPHLCCUG_RS17445	COG0406	alpha-ribazole phosphatase activity
MPHLCCUG_RS17450	COG0799	negative regulation of ribosome biogenesis
MPHLCCUG_RS17455	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
MPHLCCUG_RS17460	COG2188	Transcriptional regulator
MPHLCCUG_RS17470	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
MPHLCCUG_RS17490	COG0542	response to heat
MPHLCCUG_RS17495	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
MPHLCCUG_RS17500	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MPHLCCUG_RS17520	COG0149	triose-phosphate isomerase activity
MPHLCCUG_RS17525	COG0698	ribose 5-phosphate isomerase
MPHLCCUG_RS17530	COG2376	Dihydroxyacetone kinase
MPHLCCUG_RS17545	COG1250	3-hydroxyacyl-CoA dehydrogenase
MPHLCCUG_RS17570	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
MPHLCCUG_RS17575	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MPHLCCUG_RS17580	COG0211	Belongs to the bacterial ribosomal protein bL27 family
MPHLCCUG_RS17585	COG0261	This protein binds to 23S rRNA in the presence of protein L20
MPHLCCUG_RS17590	COG1530	ribonuclease E activity
MPHLCCUG_RS17595	COG0105	UTP biosynthetic process
MPHLCCUG_RS17620	COG0285	dihydrofolate synthase activity
MPHLCCUG_RS17625	COG0525	valine-tRNA ligase activity
MPHLCCUG_RS17635	COG3268	Saccharopine dehydrogenase
MPHLCCUG_RS17640	COG0823	Involved in the tonB-independent uptake of proteins
MPHLCCUG_RS17640	COG1506	peptidase
MPHLCCUG_RS17655	COG1652	LysM domain
MPHLCCUG_RS17660	COG1388	LysM domain
MPHLCCUG_RS17665	COG0746	molybdenum cofactor guanylyltransferase activity
MPHLCCUG_RS17670	COG1013	pyruvate-flavodoxin oxidoreductase activity
MPHLCCUG_RS17675	COG0674	pyruvate-flavodoxin oxidoreductase activity
MPHLCCUG_RS17675	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
MPHLCCUG_RS17685	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
MPHLCCUG_RS17690	COG0477	Major facilitator Superfamily
MPHLCCUG_RS17695	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
MPHLCCUG_RS17700	COG0740	serine-type endopeptidase activity
MPHLCCUG_RS17750	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
MPHLCCUG_RS17790	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
MPHLCCUG_RS17815	COG0366	Alpha amylase catalytic
MPHLCCUG_RS17830	COG2902	Dehydrogenase
MPHLCCUG_RS17840	COG0629	single-stranded DNA binding
MPHLCCUG_RS17885	COG0406	alpha-ribazole phosphatase activity
MPHLCCUG_RS17910	COG3012	SEC-C Motif Domain Protein
MPHLCCUG_RS17915	COG0508	dehydrogenase complex catalyzes the overall conversion of
MPHLCCUG_RS17940	COG1960	acyl-CoA dehydrogenase activity
MPHLCCUG_RS17950	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
MPHLCCUG_RS17965	COG2267	carboxylic ester hydrolase activity
MPHLCCUG_RS17980	COG0300	oxidoreductase activity
MPHLCCUG_RS17985	COG0433	COG0433 Predicted ATPase
MPHLCCUG_RS18000	COG1376	ErfK ybiS ycfS ynhG family protein
MPHLCCUG_RS18020	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
MPHLCCUG_RS18040	COG3321	synthase
MPHLCCUG_RS18040	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MPHLCCUG_RS18040	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
MPHLCCUG_RS18045	COG3757	hydrolase, family 25
MPHLCCUG_RS18070	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
MPHLCCUG_RS18090	COG0318	PFAM AMP-dependent synthetase and ligase
MPHLCCUG_RS18100	COG0318	PFAM AMP-dependent synthetase and ligase
MPHLCCUG_RS18155	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
MPHLCCUG_RS18180	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
MPHLCCUG_RS18185	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
MPHLCCUG_RS18200	COG1028	Short-chain dehydrogenase reductase Sdr
MPHLCCUG_RS18205	COG1028	Short-chain dehydrogenase reductase Sdr
MPHLCCUG_RS18225	COG1960	acyl-CoA dehydrogenase activity
MPHLCCUG_RS18230	COG1960	acyl-CoA dehydrogenase activity
MPHLCCUG_RS18260	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
MPHLCCUG_RS18280	COG2084	Dehydrogenase
MPHLCCUG_RS18285	COG2084	Dehydrogenase
MPHLCCUG_RS18295	COG2124	cytochrome p450
MPHLCCUG_RS18305	COG1141	Ferredoxin
MPHLCCUG_RS18325	COG4638	Rieske (2fe-2S)
MPHLCCUG_RS18355	COG4638	Rieske (2fe-2S)
MPHLCCUG_RS18380	COG0714	Associated with various cellular activities
MPHLCCUG_RS18405	COG1309	transcriptional regulator
MPHLCCUG_RS18420	COG0604	alcohol dehydrogenase
MPHLCCUG_RS18420	COG3321	synthase
MPHLCCUG_RS18420	COG1028	Short-chain dehydrogenase reductase Sdr
MPHLCCUG_RS18430	COG1309	transcriptional regulator
MPHLCCUG_RS18435	COG2124	cytochrome p450
MPHLCCUG_RS18445	COG1028	Short-chain dehydrogenase reductase Sdr
MPHLCCUG_RS18455	COG1960	acyl-CoA dehydrogenase activity
MPHLCCUG_RS18460	COG0183	Belongs to the thiolase family
MPHLCCUG_RS18470	COG1024	Enoyl-CoA hydratase
MPHLCCUG_RS18475	COG1804	L-carnitine dehydratase bile acid-inducible protein F
MPHLCCUG_RS18495	COG4638	Rieske (2fe-2S)
MPHLCCUG_RS18505	COG1228	amidohydrolase
MPHLCCUG_RS18515	COG1960	acyl-CoA dehydrogenase activity
MPHLCCUG_RS18530	COG1024	Enoyl-CoA hydratase
MPHLCCUG_RS18545	COG1028	Short-chain dehydrogenase reductase Sdr
MPHLCCUG_RS18560	COG0318	PFAM AMP-dependent synthetase and ligase
MPHLCCUG_RS18580	COG1028	Short-chain dehydrogenase reductase Sdr
MPHLCCUG_RS18585	COG1804	L-carnitine dehydratase bile acid-inducible protein F
MPHLCCUG_RS18595	COG0006	proline dipeptidase activity
MPHLCCUG_RS18645	COG1053	succinate dehydrogenase
MPHLCCUG_RS18650	COG3384	dioxygenase
MPHLCCUG_RS18655	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MPHLCCUG_RS18670	COG1053	succinate dehydrogenase
MPHLCCUG_RS18690	COG1024	Enoyl-CoA hydratase
MPHLCCUG_RS18695	COG1960	acyl-CoA dehydrogenase activity
MPHLCCUG_RS18700	COG1960	acyl-CoA dehydrogenase activity
MPHLCCUG_RS18705	COG0318	PFAM AMP-dependent synthetase and ligase
MPHLCCUG_RS18715	COG1804	L-carnitine dehydratase bile acid-inducible protein F
MPHLCCUG_RS18720	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MPHLCCUG_RS18725	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
MPHLCCUG_RS18730	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
MPHLCCUG_RS18730	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
MPHLCCUG_RS18740	COG0318	PFAM AMP-dependent synthetase and ligase
MPHLCCUG_RS18755	COG0477	Major facilitator Superfamily
MPHLCCUG_RS18780	COG1176	ABC-type spermidine putrescine transport system, permease component I
MPHLCCUG_RS18785	COG1177	transmembrane transport
MPHLCCUG_RS18800	COG0129	dihydroxy-acid dehydratase activity
MPHLCCUG_RS18805	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MPHLCCUG_RS18815	COG0156	8-amino-7-oxononanoate synthase activity
MPHLCCUG_RS18830	COG3842	ATPase activity
MPHLCCUG_RS18875	COG0714	Associated with various cellular activities
MPHLCCUG_RS18935	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MPHLCCUG_RS18940	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MPHLCCUG_RS18955	COG1566	PFAM secretion protein HlyD family protein
MPHLCCUG_RS18965	COG0477	Major facilitator Superfamily
MPHLCCUG_RS18975	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
MPHLCCUG_RS18980	COG1234	tRNA 3'-trailer cleavage
MPHLCCUG_RS18985	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
MPHLCCUG_RS19020	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
MPHLCCUG_RS19025	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
MPHLCCUG_RS19045	COG4257	antibiotic catabolic process
MPHLCCUG_RS19050	COG0058	SHG alpha-glucan phosphorylase activity
MPHLCCUG_RS19055	COG0366	Alpha amylase catalytic
MPHLCCUG_RS19070	COG2409	Drug exporters of the RND superfamily
MPHLCCUG_RS19075	COG0183	Belongs to the thiolase family
MPHLCCUG_RS19080	COG0346	lactoylglutathione lyase activity
MPHLCCUG_RS19085	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
MPHLCCUG_RS19110	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MPHLCCUG_RS19130	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
MPHLCCUG_RS19150	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
MPHLCCUG_RS19155	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
MPHLCCUG_RS19160	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
MPHLCCUG_RS19165	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MPHLCCUG_RS19165	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
MPHLCCUG_RS19175	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MPHLCCUG_RS19180	COG0356	it plays a direct role in the translocation of protons across the membrane
MPHLCCUG_RS19190	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MPHLCCUG_RS19200	COG2890	protein-(glutamine-N5) methyltransferase activity
MPHLCCUG_RS19210	COG0254	rRNA binding
MPHLCCUG_RS19220	COG0318	PFAM AMP-dependent synthetase and ligase
MPHLCCUG_RS19225	COG1309	transcriptional regulator
MPHLCCUG_RS19235	COG0083	homoserine kinase activity
MPHLCCUG_RS19240	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
MPHLCCUG_RS19245	COG0460	homoserine dehydrogenase
MPHLCCUG_RS19250	COG0019	diaminopimelate decarboxylase activity
MPHLCCUG_RS19255	COG0018	arginyl-trna synthetase
MPHLCCUG_RS19295	COG0300	oxidoreductase activity
MPHLCCUG_RS19320	COG2197	response regulator
MPHLCCUG_RS19350	COG1218	3'(2'),5'-bisphosphate nucleotidase
MPHLCCUG_RS19360	COG0175	sulfate reduction
MPHLCCUG_RS19400	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MPHLCCUG_RS19405	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MPHLCCUG_RS19410	COG2814	Major facilitator Superfamily
MPHLCCUG_RS19415	COG2205	protein histidine kinase activity
MPHLCCUG_RS19420	COG0745	RESPONSE REGULATOR receiver
MPHLCCUG_RS19500	COG0667	Aldo Keto reductase
MPHLCCUG_RS19525	COG2608	mercury ion transmembrane transporter activity
MPHLCCUG_RS19575	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MPHLCCUG_RS19595	COG0277	FAD linked oxidase domain protein
MPHLCCUG_RS19610	COG1132	(ABC) transporter
MPHLCCUG_RS19610	COG2375	cellular response to nickel ion
MPHLCCUG_RS19645	COG2814	Major facilitator Superfamily
MPHLCCUG_RS19680	COG0039	L-malate dehydrogenase activity
MPHLCCUG_RS19725	COG2301	Belongs to the HpcH HpaI aldolase family
MPHLCCUG_RS19730	COG2239	Acts as a magnesium transporter
MPHLCCUG_RS19755	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MPHLCCUG_RS19760	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MPHLCCUG_RS19765	COG5662	AntiSigma factor
MPHLCCUG_RS19770	COG1595	DNA-templated transcription, initiation
MPHLCCUG_RS19785	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
MPHLCCUG_RS19790	COG0297	glycogen (starch) synthase activity
MPHLCCUG_RS19800	COG0519	Catalyzes the synthesis of GMP from XMP
MPHLCCUG_RS19810	COG0463	Glycosyl transferase, family 2
MPHLCCUG_RS19820	COG0318	PFAM AMP-dependent synthetase and ligase
MPHLCCUG_RS19825	COG1611	Belongs to the LOG family
MPHLCCUG_RS19850	COG0488	(ABC) transporter
MPHLCCUG_RS19855	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MPHLCCUG_RS19885	COG0318	PFAM AMP-dependent synthetase and ligase
MPHLCCUG_RS19900	COG0506	proline dehydrogenase activity
MPHLCCUG_RS19905	COG1012	belongs to the aldehyde dehydrogenase family
MPHLCCUG_RS19920	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
MPHLCCUG_RS19930	COG1902	pentaerythritol trinitrate reductase activity
MPHLCCUG_RS19930	COG0446	pyridine nucleotide-disulphide oxidoreductase
MPHLCCUG_RS19960	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
MPHLCCUG_RS19980	COG0747	negative chemotaxis
MPHLCCUG_RS19985	COG1217	gtp-binding protein TYPA
MPHLCCUG_RS20000	COG2154	pterin-4-alpha-carbinolamine dehydratase
MPHLCCUG_RS20005	COG1051	belongs to the nudix hydrolase family
MPHLCCUG_RS20040	COG3275	phosphorelay sensor kinase activity
MPHLCCUG_RS20045	COG3279	Response regulator of the LytR AlgR family
MPHLCCUG_RS20055	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MPHLCCUG_RS20065	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MPHLCCUG_RS20080	COG3467	pyridoxamine 5'-phosphate
MPHLCCUG_RS20085	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
MPHLCCUG_RS20145	COG0298	carbon dioxide binding
MPHLCCUG_RS20155	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
MPHLCCUG_RS20160	COG0309	Hydrogenase expression formation protein (HypE)
MPHLCCUG_RS20165	COG0298	carbon dioxide binding
MPHLCCUG_RS20170	COG0409	Hydrogenase expression formation protein
MPHLCCUG_RS20190	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
MPHLCCUG_RS20195	COG2188	Transcriptional regulator
MPHLCCUG_RS20200	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
MPHLCCUG_RS20215	COG2409	Drug exporters of the RND superfamily
MPHLCCUG_RS20235	COG1804	L-carnitine dehydratase bile acid-inducible protein F
MPHLCCUG_RS20240	COG1024	Enoyl-CoA hydratase
MPHLCCUG_RS20255	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MPHLCCUG_RS20270	COG4977	sequence-specific DNA binding
MPHLCCUG_RS20285	COG1960	acyl-CoA dehydrogenase activity
MPHLCCUG_RS20290	COG1024	Enoyl-CoA hydratase
MPHLCCUG_RS20330	COG0318	PFAM AMP-dependent synthetase and ligase
MPHLCCUG_RS20335	COG1024	Enoyl-CoA hydratase
MPHLCCUG_RS20365	COG1960	acyl-CoA dehydrogenase activity
MPHLCCUG_RS20370	COG1024	Enoyl-CoA hydratase
MPHLCCUG_RS20380	COG1960	acyl-CoA dehydrogenase activity
MPHLCCUG_RS20385	COG1960	acyl-CoA dehydrogenase activity
MPHLCCUG_RS20390	COG0318	PFAM AMP-dependent synthetase and ligase
MPHLCCUG_RS20395	COG1960	acyl-CoA dehydrogenase activity
MPHLCCUG_RS20400	COG1960	acyl-CoA dehydrogenase activity
MPHLCCUG_RS20405	COG0318	PFAM AMP-dependent synthetase and ligase
MPHLCCUG_RS20435	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
MPHLCCUG_RS20465	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
MPHLCCUG_RS20495	COG0183	Belongs to the thiolase family
MPHLCCUG_RS20500	COG1804	L-carnitine dehydratase bile acid-inducible protein F
MPHLCCUG_RS20505	COG1012	belongs to the aldehyde dehydrogenase family
MPHLCCUG_RS20510	COG1028	Short-chain dehydrogenase reductase Sdr
MPHLCCUG_RS20530	COG2186	Transcriptional regulator
MPHLCCUG_RS20535	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
MPHLCCUG_RS20540	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MPHLCCUG_RS20550	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
MPHLCCUG_RS20575	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
MPHLCCUG_RS20580	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
MPHLCCUG_RS20590	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
MPHLCCUG_RS20610	COG1403	HNH endonuclease
MPHLCCUG_RS20660	COG2207	Transcriptional regulator
MPHLCCUG_RS20660	COG3708	Transcriptional regulator
MPHLCCUG_RS20665	COG0012	GTP binding
MPHLCCUG_RS20720	COG1028	Short-chain dehydrogenase reductase Sdr
MPHLCCUG_RS20725	COG1028	Short-chain dehydrogenase reductase Sdr
MPHLCCUG_RS20755	COG1672	PFAM Archaeal ATPase
MPHLCCUG_RS20755	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
MPHLCCUG_RS20760	COG1672	PFAM Archaeal ATPase
MPHLCCUG_RS20760	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
MPHLCCUG_RS20770	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
MPHLCCUG_RS20780	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
MPHLCCUG_RS20815	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MPHLCCUG_RS20825	COG3631	Ketosteroid isomerase-related protein
MPHLCCUG_RS20835	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
MPHLCCUG_RS20845	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
MPHLCCUG_RS20875	COG0657	acetylesterase activity
MPHLCCUG_RS20880	COG2755	lipolytic protein G-D-S-L family
MPHLCCUG_RS20885	COG0183	Belongs to the thiolase family
MPHLCCUG_RS20965	COG1301	dicarboxylic acid transport
MPHLCCUG_RS20970	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MPHLCCUG_RS20975	COG3290	protein histidine kinase activity
MPHLCCUG_RS20980	COG4565	transcriptional regulatory protein
MPHLCCUG_RS21010	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
MPHLCCUG_RS21040	COG1063	alcohol dehydrogenase
MPHLCCUG_RS21055	COG0583	DNA-binding transcription factor activity
MPHLCCUG_RS21080	COG1349	DNA-binding transcription factor activity
MPHLCCUG_RS21085	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
MPHLCCUG_RS21090	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MPHLCCUG_RS21105	COG3192	ethanolamine utilization protein
MPHLCCUG_RS21135	COG2801	Transposase and inactivated derivatives
MPHLCCUG_RS21190	COG1140	nitrate reductase beta subunit
MPHLCCUG_RS21260	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
MPHLCCUG_RS21340	COG3956	TIGRFAM MazG family protein
MPHLCCUG_RS21390	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
MPHLCCUG_RS21415	COG1309	transcriptional regulator
MPHLCCUG_RS21425	COG0318	PFAM AMP-dependent synthetase and ligase
MPHLCCUG_RS21430	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
MPHLCCUG_RS21440	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
MPHLCCUG_RS21445	COG3583	domain protein
MPHLCCUG_RS21450	COG0084	hydrolase, TatD family'
MPHLCCUG_RS21460	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
MPHLCCUG_RS21510	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
MPHLCCUG_RS21515	COG1309	transcriptional regulator
MPHLCCUG_RS21520	COG0438	transferase activity, transferring glycosyl groups
MPHLCCUG_RS21535	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
MPHLCCUG_RS21550	COG4977	sequence-specific DNA binding
MPHLCCUG_RS21555	COG4948	Mandelate Racemase Muconate Lactonizing
MPHLCCUG_RS21575	COG0318	PFAM AMP-dependent synthetase and ligase
MPHLCCUG_RS21580	COG1228	amidohydrolase
MPHLCCUG_RS21645	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
MPHLCCUG_RS21655	COG0318	PFAM AMP-dependent synthetase and ligase
MPHLCCUG_RS21675	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
MPHLCCUG_RS21690	COG1028	Short-chain dehydrogenase reductase Sdr
MPHLCCUG_RS21695	COG0300	oxidoreductase activity
MPHLCCUG_RS21700	COG0531	amino acid
MPHLCCUG_RS21770	COG1028	Short-chain dehydrogenase reductase Sdr
MPHLCCUG_RS21790	COG2070	2-Nitropropane dioxygenase
MPHLCCUG_RS21800	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
MPHLCCUG_RS21805	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
MPHLCCUG_RS21845	COG0714	Associated with various cellular activities
MPHLCCUG_RS21895	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MPHLCCUG_RS21905	COG0785	Cytochrome C biogenesis protein
MPHLCCUG_RS21915	COG0406	alpha-ribazole phosphatase activity
MPHLCCUG_RS21920	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
MPHLCCUG_RS21930	COG2837	iron assimilation
MPHLCCUG_RS21955	COG2124	cytochrome p450
MPHLCCUG_RS22005	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MPHLCCUG_RS22015	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
MPHLCCUG_RS22030	COG2030	dehydratase
MPHLCCUG_RS22080	COG0745	RESPONSE REGULATOR receiver
MPHLCCUG_RS22085	COG5002	protein histidine kinase activity
MPHLCCUG_RS22100	COG0438	transferase activity, transferring glycosyl groups
MPHLCCUG_RS22120	COG0812	UDP-N-acetylmuramate dehydrogenase activity
MPHLCCUG_RS22145	COG0010	Belongs to the arginase family
MPHLCCUG_RS22175	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
MPHLCCUG_RS22200	COG2733	membrane
MPHLCCUG_RS22210	COG2326	polyphosphate kinase activity
MPHLCCUG_RS22290	COG1116	anion transmembrane transporter activity
MPHLCCUG_RS22295	COG0444	Belongs to the ABC transporter superfamily
MPHLCCUG_RS22300	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MPHLCCUG_RS22305	COG0601	transmembrane transport
MPHLCCUG_RS22330	COG1505	serine-type exopeptidase activity
MPHLCCUG_RS22340	COG2822	iron ion transport
MPHLCCUG_RS22360	COG1012	belongs to the aldehyde dehydrogenase family
MPHLCCUG_RS22365	COG1309	transcriptional regulator
MPHLCCUG_RS22385	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
MPHLCCUG_RS22385	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
MPHLCCUG_RS22410	COG0459	protein refolding
MPHLCCUG_RS22415	COG0450	alkyl hydroperoxide reductase
MPHLCCUG_RS22420	COG3634	alkyl hydroperoxide reductase activity
MPHLCCUG_RS22430	COG4721	ABC-type cobalt transport system, permease component
MPHLCCUG_RS22435	COG1122	ATPase activity
MPHLCCUG_RS22445	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MPHLCCUG_RS22455	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MPHLCCUG_RS22475	COG0647	UMP catabolic process
MPHLCCUG_RS22490	COG1028	Short-chain dehydrogenase reductase Sdr
MPHLCCUG_RS22500	COG0688	phosphatidylethanolamine metabolic process
MPHLCCUG_RS22510	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MPHLCCUG_RS22525	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MPHLCCUG_RS22525	COG2111	Na H antiporter
MPHLCCUG_RS22530	COG1006	Multisubunit Na H antiporter MnhC subunit
MPHLCCUG_RS22535	COG0651	ATP synthesis coupled electron transport
MPHLCCUG_RS22545	COG2212	antiporter activity
MPHLCCUG_RS22550	COG1320	monovalent cation:proton antiporter activity
MPHLCCUG_RS22585	COG0242	peptide deformylase activity
MPHLCCUG_RS22600	COG1403	HNH endonuclease
MPHLCCUG_RS22610	COG0351	phosphomethylpyrimidine kinase
MPHLCCUG_RS22625	COG2072	flavoprotein involved in K transport
MPHLCCUG_RS22635	COG1309	transcriptional regulator
MPHLCCUG_RS22655	COG2233	PERMEase
MPHLCCUG_RS22660	COG2234	aminopeptidase activity
MPHLCCUG_RS22665	COG2234	aminopeptidase activity
MPHLCCUG_RS22695	COG1131	(ABC) transporter
MPHLCCUG_RS22705	COG2022	thiamine diphosphate biosynthetic process
MPHLCCUG_RS22715	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MPHLCCUG_RS22715	COG2022	thiamine diphosphate biosynthetic process
MPHLCCUG_RS22720	COG0352	thiamine-phosphate diphosphorylase activity
MPHLCCUG_RS22735	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MPHLCCUG_RS22740	COG0515	serine threonine protein kinase
MPHLCCUG_RS22745	COG1366	Belongs to the anti-sigma-factor antagonist family
MPHLCCUG_RS22750	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
MPHLCCUG_RS22790	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MPHLCCUG_RS22800	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MPHLCCUG_RS22810	COG0300	oxidoreductase activity
MPHLCCUG_RS22845	COG2409	Drug exporters of the RND superfamily
MPHLCCUG_RS22855	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
MPHLCCUG_RS22865	COG1994	Peptidase M50
MPHLCCUG_RS22895	COG0586	Pfam SNARE associated Golgi protein
MPHLCCUG_RS22900	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
MPHLCCUG_RS22900	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
MPHLCCUG_RS22935	COG0542	response to heat
MPHLCCUG_RS22950	COG1607	acyl-coa hydrolase
MPHLCCUG_RS22955	COG0604	alcohol dehydrogenase
MPHLCCUG_RS23035	COG0789	Transcriptional regulator
MPHLCCUG_RS23040	COG0484	heat shock protein binding
MPHLCCUG_RS23045	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
MPHLCCUG_RS23050	COG0443	Heat shock 70 kDa protein
MPHLCCUG_RS23110	COG2181	nitrate reductase activity
MPHLCCUG_RS23110	COG0247	lactate metabolic process
MPHLCCUG_RS23145	COG0717	Belongs to the dCTP deaminase family
MPHLCCUG_RS23190	COG0747	negative chemotaxis
MPHLCCUG_RS23195	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MPHLCCUG_RS23205	COG0444	Belongs to the ABC transporter superfamily
MPHLCCUG_RS23210	COG4608	Belongs to the ABC transporter superfamily
MPHLCCUG_RS23220	COG0723	plastoquinol--plastocyanin reductase activity
MPHLCCUG_RS23255	COG0531	amino acid
MPHLCCUG_RS23265	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MPHLCCUG_RS23275	COG0058	SHG alpha-glucan phosphorylase activity
MPHLCCUG_RS23300	COG1404	Belongs to the peptidase S8 family
MPHLCCUG_RS23315	COG4842	Belongs to the WXG100 family
MPHLCCUG_RS23335	COG1674	ftsk spoiiie
MPHLCCUG_RS23340	COG3266	domain, Protein
MPHLCCUG_RS23345	COG0464	growth
MPHLCCUG_RS23360	COG0346	lactoylglutathione lyase activity
MPHLCCUG_RS23370	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MPHLCCUG_RS23375	COG1960	acyl-CoA dehydrogenase activity
MPHLCCUG_RS23390	COG0318	PFAM AMP-dependent synthetase and ligase
MPHLCCUG_RS23395	COG3285	dna ligase
MPHLCCUG_RS23395	COG1793	dna ligase
MPHLCCUG_RS23410	COG2252	PERMEase
MPHLCCUG_RS23445	COG1028	Short-chain dehydrogenase reductase Sdr
MPHLCCUG_RS23450	COG2124	cytochrome p450
MPHLCCUG_RS23495	COG1024	Enoyl-CoA hydratase
MPHLCCUG_RS23510	COG1960	acyl-CoA dehydrogenase activity
MPHLCCUG_RS23525	COG1024	Enoyl-CoA hydratase
MPHLCCUG_RS23540	COG2770	Histidine kinase
MPHLCCUG_RS23540	COG2208	phosphoserine phosphatase activity
MPHLCCUG_RS23590	COG1028	Short-chain dehydrogenase reductase Sdr
MPHLCCUG_RS23600	COG1012	belongs to the aldehyde dehydrogenase family
MPHLCCUG_RS23605	COG1960	acyl-CoA dehydrogenase activity
MPHLCCUG_RS23615	COG1309	transcriptional regulator
MPHLCCUG_RS23620	COG4221	oxidoreductase activity
MPHLCCUG_RS23625	COG2855	membrane
MPHLCCUG_RS23640	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
MPHLCCUG_RS23645	COG1984	allophanate hydrolase subunit 2
MPHLCCUG_RS23670	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MPHLCCUG_RS23670	COG2146	nitrite reductase [NAD(P)H] activity
MPHLCCUG_RS23710	COG0714	Associated with various cellular activities
MPHLCCUG_RS23745	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MPHLCCUG_RS23755	COG5651	PPE family
MPHLCCUG_RS23760	COG0318	PFAM AMP-dependent synthetase and ligase
MPHLCCUG_RS23780	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
MPHLCCUG_RS23785	COG1960	acyl-CoA dehydrogenase activity
MPHLCCUG_RS23790	COG2197	response regulator
MPHLCCUG_RS23795	COG4585	Histidine kinase
MPHLCCUG_RS23800	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MPHLCCUG_RS23810	COG0183	Belongs to the thiolase family
MPHLCCUG_RS23815	COG1028	Short-chain dehydrogenase reductase Sdr
MPHLCCUG_RS23820	COG2030	dehydratase
MPHLCCUG_RS23830	COG1472	Belongs to the glycosyl hydrolase 3 family
MPHLCCUG_RS23840	COG2814	Major facilitator Superfamily
MPHLCCUG_RS23870	COG0297	glycogen (starch) synthase activity
MPHLCCUG_RS23885	COG1960	acyl-CoA dehydrogenase activity
MPHLCCUG_RS23905	COG1024	Enoyl-CoA hydratase
MPHLCCUG_RS23920	COG0657	acetylesterase activity
MPHLCCUG_RS23930	COG0657	acetylesterase activity
MPHLCCUG_RS23935	COG1960	acyl-CoA dehydrogenase activity
MPHLCCUG_RS23955	COG0657	acetylesterase activity
MPHLCCUG_RS23980	COG2188	Transcriptional regulator
MPHLCCUG_RS23985	COG1024	Enoyl-CoA hydratase
MPHLCCUG_RS23995	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
MPHLCCUG_RS24020	COG2409	Drug exporters of the RND superfamily
MPHLCCUG_RS24060	COG2409	Drug exporters of the RND superfamily
MPHLCCUG_RS24070	COG1832	CoA-binding protein
MPHLCCUG_RS24095	COG3590	peptidase
MPHLCCUG_RS24100	COG1376	ErfK ybiS ycfS ynhG family protein
MPHLCCUG_RS24115	COG1937	Protein conserved in bacteria
MPHLCCUG_RS24135	COG4122	O-methyltransferase activity
MPHLCCUG_RS24160	COG1982	Orn Lys Arg decarboxylase major
MPHLCCUG_RS24175	COG1309	transcriptional regulator
MPHLCCUG_RS24210	COG3328	transposase activity
MPHLCCUG_RS24235	COG1335	isochorismatase
MPHLCCUG_RS24265	COG0366	Alpha amylase catalytic
MPHLCCUG_RS24275	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
MPHLCCUG_RS24280	COG3842	ATPase activity
MPHLCCUG_RS24340	COG1366	Belongs to the anti-sigma-factor antagonist family
MPHLCCUG_RS24425	COG3467	pyridoxamine 5'-phosphate
MPHLCCUG_RS24435	COG1643	Atp-dependent helicase
MPHLCCUG_RS24465	COG3415	Transposase
MPHLCCUG_RS24465	COG2801	Transposase and inactivated derivatives
MPHLCCUG_RS24480	COG0300	oxidoreductase activity
MPHLCCUG_RS24485	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
MPHLCCUG_RS24495	COG1028	Short-chain dehydrogenase reductase Sdr
MPHLCCUG_RS24505	COG1028	Short-chain dehydrogenase reductase Sdr
MPHLCCUG_RS24530	COG0778	Nitroreductase
MPHLCCUG_RS24545	COG1028	Short-chain dehydrogenase reductase Sdr
MPHLCCUG_RS24550	COG1595	DNA-templated transcription, initiation
MPHLCCUG_RS24570	COG0657	acetylesterase activity
MPHLCCUG_RS24580	COG0318	PFAM AMP-dependent synthetase and ligase
MPHLCCUG_RS24585	COG1408	metallophosphoesterase
MPHLCCUG_RS24590	COG1960	acyl-CoA dehydrogenase activity
MPHLCCUG_RS24595	COG1960	acyl-CoA dehydrogenase activity
MPHLCCUG_RS24600	COG0494	nUDIX hydrolase
MPHLCCUG_RS24605	COG1309	transcriptional regulator
MPHLCCUG_RS24665	COG1403	HNH endonuclease
MPHLCCUG_RS24670	COG1028	Short-chain dehydrogenase reductase Sdr
MPHLCCUG_RS24705	COG1845	cytochrome c oxidase, subunit III
MPHLCCUG_RS24720	COG0346	lactoylglutathione lyase activity
MPHLCCUG_RS24735	COG4941	Belongs to the sigma-70 factor family
MPHLCCUG_RS24740	COG3795	YCII-related domain
MPHLCCUG_RS24760	COG1028	Short-chain dehydrogenase reductase Sdr
MPHLCCUG_RS24765	COG1960	acyl-CoA dehydrogenase activity
MPHLCCUG_RS24770	COG1028	Short-chain dehydrogenase reductase Sdr
MPHLCCUG_RS24785	COG1053	succinate dehydrogenase
MPHLCCUG_RS24790	COG1053	succinate dehydrogenase
MPHLCCUG_RS24805	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
MPHLCCUG_RS24830	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
MPHLCCUG_RS24835	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
MPHLCCUG_RS24840	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
MPHLCCUG_RS24855	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MPHLCCUG_RS24860	COG1804	L-carnitine dehydratase bile acid-inducible protein F
MPHLCCUG_RS24875	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MPHLCCUG_RS24895	COG1804	L-carnitine dehydratase bile acid-inducible protein F
MPHLCCUG_RS24900	COG1028	Short-chain dehydrogenase reductase Sdr
MPHLCCUG_RS24930	COG1960	acyl-CoA dehydrogenase activity
MPHLCCUG_RS24935	COG1960	acyl-CoA dehydrogenase activity
MPHLCCUG_RS24940	COG1804	L-carnitine dehydratase bile acid-inducible protein F
MPHLCCUG_RS24945	COG0583	DNA-binding transcription factor activity
MPHLCCUG_RS24950	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
MPHLCCUG_RS24955	COG1116	anion transmembrane transporter activity
MPHLCCUG_RS24965	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MPHLCCUG_RS24975	COG1063	alcohol dehydrogenase
MPHLCCUG_RS24980	COG3639	organic phosphonate transmembrane transporter activity
MPHLCCUG_RS24985	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
MPHLCCUG_RS24990	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MPHLCCUG_RS25005	COG2188	Transcriptional regulator
MPHLCCUG_RS25030	COG0174	glutamine synthetase
MPHLCCUG_RS25035	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
MPHLCCUG_RS25040	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
MPHLCCUG_RS25045	COG1609	Transcriptional regulator
MPHLCCUG_RS25050	COG0604	alcohol dehydrogenase
MPHLCCUG_RS25055	COG1960	acyl-CoA dehydrogenase activity
MPHLCCUG_RS25060	COG1960	acyl-CoA dehydrogenase activity
MPHLCCUG_RS25070	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
MPHLCCUG_RS25085	COG0765	amino acid transport
MPHLCCUG_RS25090	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MPHLCCUG_RS25120	COG1028	Short-chain dehydrogenase reductase Sdr
MPHLCCUG_RS25130	COG2030	dehydratase
MPHLCCUG_RS25145	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
MPHLCCUG_RS25150	COG2186	Transcriptional regulator
MPHLCCUG_RS25155	COG2807	transmembrane transport
MPHLCCUG_RS25195	COG0277	FAD linked oxidase domain protein
MPHLCCUG_RS25195	COG0247	lactate metabolic process
MPHLCCUG_RS25200	COG1609	Transcriptional regulator
MPHLCCUG_RS25205	COG1072	(Pantothenic acid kinase))
MPHLCCUG_RS25250	COG1301	dicarboxylic acid transport
MPHLCCUG_RS25310	COG0359	binds to the 23S rRNA
MPHLCCUG_RS25315	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
MPHLCCUG_RS25325	COG0360	Binds together with S18 to 16S ribosomal RNA
MPHLCCUG_RS25340	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MPHLCCUG_RS25365	COG1260	myo-inositol-1-phosphate synthase
MPHLCCUG_RS25370	COG0596	Alpha beta hydrolase
MPHLCCUG_RS25370	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MPHLCCUG_RS25390	COG0765	amino acid transport
MPHLCCUG_RS25395	COG1126	abc transporter atp-binding protein
MPHLCCUG_RS25405	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
MPHLCCUG_RS25410	COG4221	oxidoreductase activity
MPHLCCUG_RS25420	COG0495	leucyl-tRNA aminoacylation
MPHLCCUG_RS25435	COG1678	Uncharacterized ACR, COG1678
MPHLCCUG_RS25455	COG0617	tRNA 3'-terminal CCA addition
MPHLCCUG_RS25455	COG1353	crispr-associated protein
MPHLCCUG_RS25475	COG1595	DNA-templated transcription, initiation
MPHLCCUG_RS25495	COG3409	Peptidoglycan-binding domain 1 protein
MPHLCCUG_RS25495	COG0860	N-Acetylmuramoyl-L-alanine amidase
MPHLCCUG_RS25510	COG1192	Involved in chromosome partitioning
MPHLCCUG_RS25515	COG0357	Ribosomal RNA small subunit methyltransferase G
MPHLCCUG_RS25525	COG0706	membrane insertase activity
MPHLCCUG_RS25530	COG0230	Belongs to the bacterial ribosomal protein bL34 family
MPHLCCUG_RS25555	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MPHLCCUG_RS25585	COG2826	transposase and inactivated derivatives, IS30 family
MPHLCCUG_RS25680	COG3321	synthase
MPHLCCUG_RS25680	COG1028	Short-chain dehydrogenase reductase Sdr
MPHLCCUG_RS25680	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MPHLCCUG_RS25680	COG0318	PFAM AMP-dependent synthetase and ligase
MPHLCCUG_RS25680	COG0300	oxidoreductase activity
MPHLCCUG_RS25715	COG0183	Belongs to the thiolase family
MPHLCCUG_RS25800	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MPHLCCUG_RS25870	COG2801	Transposase and inactivated derivatives
MPHLCCUG_RS25915	COG5651	PPE family
MPHLCCUG_RS25920	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MPHLCCUG_RS25980	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
MPHLCCUG_RS25985	COG0594	ribonuclease P activity