locus-tag	class	description
LI99_RS00005	COG0592	DNA-directed DNA polymerase activity
LI99_RS00010	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
LI99_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LI99_RS00020	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
LI99_RS00025	COG0187	DNA topoisomerase II activity
LI99_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
LI99_RS00060	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LI99_RS00065	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LI99_RS00070	COG1120	ATPase activity
LI99_RS00075	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LI99_RS00090	COG1132	(ABC) transporter
LI99_RS00105	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
LI99_RS00110	COG3486	L-lysine 6-monooxygenase (NADPH) activity
LI99_RS00145	COG2815	serine threonine protein kinase
LI99_RS00145	COG0515	serine threonine protein kinase
LI99_RS00150	COG0515	serine threonine protein kinase
LI99_RS00155	COG0768	penicillin binding
LI99_RS00170	COG1716	ATPase activity
LI99_RS00175	COG1716	ATPase activity
LI99_RS00210	COG3384	dioxygenase
LI99_RS00225	COG1100	Small GTP-binding protein
LI99_RS00290	COG0464	growth
LI99_RS00295	COG3266	domain, Protein
LI99_RS00305	COG1674	ftsk spoiiie
LI99_RS00320	COG4842	Belongs to the WXG100 family
LI99_RS00325	COG4842	Belongs to the WXG100 family
LI99_RS00415	COG1404	Belongs to the peptidase S8 family
LI99_RS00425	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LI99_RS00425	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
LI99_RS00425	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LI99_RS00435	COG1349	DNA-binding transcription factor activity
LI99_RS00440	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LI99_RS00465	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
LI99_RS00470	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
LI99_RS00480	COG1028	Short-chain dehydrogenase reductase Sdr
LI99_RS00485	COG1063	alcohol dehydrogenase
LI99_RS00505	COG2365	Tyrosine phosphatase family
LI99_RS00510	COG1960	acyl-CoA dehydrogenase activity
LI99_RS00515	COG2814	Major facilitator Superfamily
LI99_RS00520	COG0583	DNA-binding transcription factor activity
LI99_RS00530	COG4585	Histidine kinase
LI99_RS00540	COG1960	acyl-CoA dehydrogenase activity
LI99_RS00545	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
LI99_RS00550	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
LI99_RS00565	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LI99_RS00570	COG4521	taurine ABC transporter
LI99_RS00575	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
LI99_RS00625	COG2186	Transcriptional regulator
LI99_RS00650	COG1802	Transcriptional regulator
LI99_RS00660	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LI99_RS00665	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LI99_RS00690	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
LI99_RS00720	COG3619	membrane
LI99_RS00765	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
LI99_RS00775	COG4191	Histidine kinase
LI99_RS00780	COG0583	DNA-binding transcription factor activity
LI99_RS00785	COG0028	Belongs to the TPP enzyme family
LI99_RS00805	COG3383	formate dehydrogenase (NAD+) activity
LI99_RS00825	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
LI99_RS00830	COG1802	Transcriptional regulator
LI99_RS00835	COG2223	nitrite transmembrane transporter activity
LI99_RS00840	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LI99_RS00850	COG2223	nitrite transmembrane transporter activity
LI99_RS00875	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LI99_RS00880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LI99_RS00890	COG1126	abc transporter atp-binding protein
LI99_RS00895	COG1802	Transcriptional regulator
LI99_RS00905	COG2175	clavaminate synthase activity
LI99_RS00910	COG0596	Alpha beta hydrolase
LI99_RS00915	COG0405	Gamma-glutamyltransferase
LI99_RS00925	COG1033	growth of symbiont in host cell
LI99_RS00925	COG2409	Drug exporters of the RND superfamily
LI99_RS00940	COG0456	acetyltransferase
LI99_RS00945	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
LI99_RS00950	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LI99_RS00960	COG1737	Transcriptional regulator
LI99_RS00965	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
LI99_RS00975	COG2072	flavoprotein involved in K transport
LI99_RS00985	COG1051	belongs to the nudix hydrolase family
LI99_RS00995	COG3001	Fructosamine kinase
LI99_RS01020	COG2329	Antibiotic biosynthesis monooxygenase
LI99_RS01030	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
LI99_RS01030	COG2755	lipolytic protein G-D-S-L family
LI99_RS01050	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LI99_RS01095	COG2267	carboxylic ester hydrolase activity
LI99_RS01115	COG4122	O-methyltransferase activity
LI99_RS01145	COG1937	Protein conserved in bacteria
LI99_RS01160	COG1376	ErfK ybiS ycfS ynhG family protein
LI99_RS01165	COG3590	peptidase
LI99_RS01185	COG1832	CoA-binding protein
LI99_RS01190	COG2873	o-acetylhomoserine
LI99_RS01200	COG2409	Drug exporters of the RND superfamily
LI99_RS01220	COG2205	protein histidine kinase activity
LI99_RS01245	COG2409	Drug exporters of the RND superfamily
LI99_RS01270	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
LI99_RS01285	COG1024	Enoyl-CoA hydratase
LI99_RS01290	COG4221	oxidoreductase activity
LI99_RS01300	COG2030	dehydratase
LI99_RS01320	COG1982	Orn Lys Arg decarboxylase major
LI99_RS01325	COG1573	uracil-dna glycosylase
LI99_RS01330	COG0657	acetylesterase activity
LI99_RS01340	COG1028	Short-chain dehydrogenase reductase Sdr
LI99_RS01350	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
LI99_RS01360	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
LI99_RS01370	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
LI99_RS01375	COG1454	alcohol dehydrogenase
LI99_RS01375	COG1012	belongs to the aldehyde dehydrogenase family
LI99_RS01395	COG0657	acetylesterase activity
LI99_RS01425	COG2188	Transcriptional regulator
LI99_RS01440	COG0657	acetylesterase activity
LI99_RS01465	COG1028	Short-chain dehydrogenase reductase Sdr
LI99_RS01470	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LI99_RS01500	COG0277	FAD linked oxidase domain protein
LI99_RS01505	COG1064	alcohol dehydrogenase
LI99_RS01510	COG0657	acetylesterase activity
LI99_RS01515	COG0318	PFAM AMP-dependent synthetase and ligase
LI99_RS01550	COG0297	glycogen (starch) synthase activity
LI99_RS01555	COG0800	Aldolase
LI99_RS01565	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
LI99_RS01570	COG1940	carbohydrate kinase activity
LI99_RS01570	COG1846	Transcriptional regulator
LI99_RS01620	COG0318	PFAM AMP-dependent synthetase and ligase
LI99_RS01625	COG1012	belongs to the aldehyde dehydrogenase family
LI99_RS01640	COG2909	trisaccharide binding
LI99_RS01655	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LI99_RS01665	COG1024	Enoyl-CoA hydratase
LI99_RS01685	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LI99_RS01690	COG1024	Enoyl-CoA hydratase
LI99_RS01710	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LI99_RS01715	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LI99_RS01740	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
LI99_RS01775	COG2814	Major facilitator Superfamily
LI99_RS01780	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LI99_RS01785	COG4981	capsule polysaccharide biosynthetic process
LI99_RS01795	COG1472	Belongs to the glycosyl hydrolase 3 family
LI99_RS01845	COG2030	dehydratase
LI99_RS01850	COG1028	Short-chain dehydrogenase reductase Sdr
LI99_RS01855	COG0183	Belongs to the thiolase family
LI99_RS01860	COG0277	FAD linked oxidase domain protein
LI99_RS01910	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
LI99_RS01955	COG2226	methyltransferase
LI99_RS01995	COG3795	YCII-related domain
LI99_RS02000	COG4941	Belongs to the sigma-70 factor family
LI99_RS02005	COG1960	acyl-CoA dehydrogenase activity
LI99_RS02030	COG0318	PFAM AMP-dependent synthetase and ligase
LI99_RS02035	COG5651	PPE family
LI99_RS02065	COG1053	succinate dehydrogenase
LI99_RS02080	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
LI99_RS02100	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LI99_RS02105	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LI99_RS02105	COG2146	nitrite reductase [NAD(P)H] activity
LI99_RS02140	COG0456	acetyltransferase
LI99_RS02145	COG1984	allophanate hydrolase subunit 2
LI99_RS02150	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
LI99_RS02165	COG2855	membrane
LI99_RS02185	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LI99_RS02190	COG2957	Belongs to the agmatine deiminase family
LI99_RS02200	COG0531	amino acid
LI99_RS02205	COG1764	response to oxidative stress
LI99_RS02210	COG1846	Transcriptional regulator
LI99_RS02225	COG2610	gluconate transmembrane transporter activity
LI99_RS02230	COG3265	gluconokinase activity
LI99_RS02245	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
LI99_RS02250	COG0187	DNA topoisomerase II activity
LI99_RS02270	COG1739	Uncharacterized protein family UPF0029
LI99_RS02285	COG1309	transcriptional regulator
LI99_RS02290	COG0351	phosphomethylpyrimidine kinase
LI99_RS02305	COG0456	acetyltransferase
LI99_RS02305	COG1846	Transcriptional regulator
LI99_RS02330	COG2197	response regulator
LI99_RS02345	COG1215	transferase activity, transferring glycosyl groups
LI99_RS02370	COG0129	dihydroxy-acid dehydratase activity
LI99_RS02375	COG0477	Major facilitator Superfamily
LI99_RS02395	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LI99_RS02400	COG1116	anion transmembrane transporter activity
LI99_RS02405	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LI99_RS02410	COG1024	Enoyl-CoA hydratase
LI99_RS02415	COG1609	Transcriptional regulator
LI99_RS02465	COG0363	glucosamine-6-phosphate deaminase activity
LI99_RS02470	COG1486	melibiose metabolic process
LI99_RS02475	COG1349	DNA-binding transcription factor activity
LI99_RS02490	COG1175	transmembrane transport
LI99_RS02495	COG0395	ABC-type sugar transport system, permease component
LI99_RS02500	COG3842	ATPase activity
LI99_RS02515	COG2222	sugar isomerase
LI99_RS02530	COG1486	melibiose metabolic process
LI99_RS02535	COG2182	Extracellular solute-binding protein
LI99_RS02540	COG1175	transmembrane transport
LI99_RS02545	COG0395	ABC-type sugar transport system, permease component
LI99_RS02550	COG3842	ATPase activity
LI99_RS02580	COG1028	Short-chain dehydrogenase reductase Sdr
LI99_RS02590	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
LI99_RS02595	COG1028	Short-chain dehydrogenase reductase Sdr
LI99_RS02610	COG1028	Short-chain dehydrogenase reductase Sdr
LI99_RS02615	COG1960	acyl-CoA dehydrogenase activity
LI99_RS02620	COG1309	transcriptional regulator
LI99_RS02640	COG0693	protein deglycase activity
LI99_RS02650	COG1846	Transcriptional regulator
LI99_RS02675	COG3707	response regulator
LI99_RS02710	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LI99_RS02715	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LI99_RS02720	COG1116	anion transmembrane transporter activity
LI99_RS02735	COG1175	transmembrane transport
LI99_RS02740	COG0395	ABC-type sugar transport system, permease component
LI99_RS02745	COG3842	ATPase activity
LI99_RS02760	COG1278	Cold shock
LI99_RS02780	COG2354	Protein conserved in bacteria
LI99_RS02785	COG2252	PERMEase
LI99_RS02790	COG0297	glycogen (starch) synthase activity
LI99_RS02800	COG2144	transferase activity, transferring acyl groups
LI99_RS02810	COG2072	flavoprotein involved in K transport
LI99_RS02820	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LI99_RS02830	COG1595	DNA-templated transcription, initiation
LI99_RS02855	COG1960	acyl-CoA dehydrogenase activity
LI99_RS02885	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LI99_RS02890	COG1366	Belongs to the anti-sigma-factor antagonist family
LI99_RS02895	COG3254	rhamnose metabolic process
LI99_RS02900	COG2814	Major facilitator Superfamily
LI99_RS02910	COG1028	Short-chain dehydrogenase reductase Sdr
LI99_RS02910	COG3347	Dehydrogenase
LI99_RS02920	COG1609	Transcriptional regulator
LI99_RS02925	COG1556	Lactate utilization protein
LI99_RS02935	COG0247	lactate metabolic process
LI99_RS02940	COG2186	Transcriptional regulator
LI99_RS02955	COG0318	PFAM AMP-dependent synthetase and ligase
LI99_RS02960	COG1028	Short-chain dehydrogenase reductase Sdr
LI99_RS02970	COG1960	acyl-CoA dehydrogenase activity
LI99_RS02990	COG0346	lactoylglutathione lyase activity
LI99_RS02995	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
LI99_RS03005	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LI99_RS03025	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
LI99_RS03030	COG0464	growth
LI99_RS03035	COG3266	domain, Protein
LI99_RS03040	COG1674	ftsk spoiiie
LI99_RS03060	COG4842	Belongs to the WXG100 family
LI99_RS03075	COG1404	Belongs to the peptidase S8 family
LI99_RS03090	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
LI99_RS03100	COG4106	trans-aconitate 2-methyltransferase activity
LI99_RS03105	COG4424	Sulfotransferase
LI99_RS03110	COG3119	arylsulfatase activity
LI99_RS03120	COG0671	phosphoesterase, PA-phosphatase related
LI99_RS03140	COG0723	plastoquinol--plastocyanin reductase activity
LI99_RS03150	COG4608	Belongs to the ABC transporter superfamily
LI99_RS03155	COG0444	Belongs to the ABC transporter superfamily
LI99_RS03160	COG0601	transmembrane transport
LI99_RS03165	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LI99_RS03185	COG3639	organic phosphonate transmembrane transporter activity
LI99_RS03190	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
LI99_RS03195	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
LI99_RS03200	COG2188	Transcriptional regulator
LI99_RS03240	COG1177	transmembrane transport
LI99_RS03245	COG1176	ABC-type spermidine putrescine transport system, permease component I
LI99_RS03255	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LI99_RS03260	COG3842	ATPase activity
LI99_RS03280	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LI99_RS03285	COG1960	acyl-CoA dehydrogenase activity
LI99_RS03295	COG0492	ferredoxin-NADP+ reductase activity
LI99_RS03305	COG1063	alcohol dehydrogenase
LI99_RS03320	COG1376	ErfK ybiS ycfS ynhG family protein
LI99_RS03340	COG0717	Belongs to the dCTP deaminase family
LI99_RS03350	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
LI99_RS03370	COG1529	Aldehyde oxidase and xanthine dehydrogenase
LI99_RS03375	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
LI99_RS03380	COG2080	2 iron, 2 sulfur cluster binding
LI99_RS03400	COG2181	nitrate reductase activity
LI99_RS03400	COG0247	lactate metabolic process
LI99_RS03480	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LI99_RS03485	COG0473	3-isopropylmalate dehydrogenase activity
LI99_RS03485	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LI99_RS03495	COG0443	Heat shock 70 kDa protein
LI99_RS03500	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LI99_RS03505	COG0484	heat shock protein binding
LI99_RS03510	COG0789	Transcriptional regulator
LI99_RS03525	COG1028	Short-chain dehydrogenase reductase Sdr
LI99_RS03530	COG0477	Major facilitator Superfamily
LI99_RS03535	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LI99_RS03610	COG0542	response to heat
LI99_RS03685	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
LI99_RS03685	COG3608	succinylglutamate desuccinylase aspartoacylase
LI99_RS03705	COG0586	Pfam SNARE associated Golgi protein
LI99_RS03735	COG1994	Peptidase M50
LI99_RS03745	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LI99_RS03760	COG2124	cytochrome p450
LI99_RS03765	COG2409	Drug exporters of the RND superfamily
LI99_RS03805	COG4221	oxidoreductase activity
LI99_RS03820	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LI99_RS03830	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
LI99_RS03835	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LI99_RS03840	COG1725	Transcriptional regulator
LI99_RS03845	COG1028	Short-chain dehydrogenase reductase Sdr
LI99_RS03860	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
LI99_RS03870	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LI99_RS03880	COG0515	serine threonine protein kinase
LI99_RS03885	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LI99_RS03900	COG0352	thiamine-phosphate diphosphorylase activity
LI99_RS03905	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LI99_RS03905	COG2022	thiamine diphosphate biosynthetic process
LI99_RS03915	COG2022	thiamine diphosphate biosynthetic process
LI99_RS03980	COG2234	aminopeptidase activity
LI99_RS03985	COG2234	aminopeptidase activity
LI99_RS04000	COG0644	oxidoreductase
LI99_RS04005	COG2233	PERMEase
LI99_RS04020	COG1309	transcriptional regulator
LI99_RS04035	COG0583	DNA-binding transcription factor activity
LI99_RS04040	COG0477	Major facilitator Superfamily
LI99_RS04045	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LI99_RS04050	COG0154	amidase activity
LI99_RS04085	COG2814	Major facilitator Superfamily
LI99_RS04100	COG1028	Short-chain dehydrogenase reductase Sdr
LI99_RS04110	COG0242	peptide deformylase activity
LI99_RS04125	COG2032	superoxide dismutase activity
LI99_RS04130	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
LI99_RS04140	COG1522	sequence-specific DNA binding
LI99_RS04160	COG1320	monovalent cation:proton antiporter activity
LI99_RS04165	COG2212	antiporter activity
LI99_RS04175	COG0651	ATP synthesis coupled electron transport
LI99_RS04185	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LI99_RS04185	COG2111	Na H antiporter
LI99_RS04215	COG4585	Histidine kinase
LI99_RS04220	COG2197	response regulator
LI99_RS04240	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LI99_RS04250	COG0688	phosphatidylethanolamine metabolic process
LI99_RS04260	COG1028	Short-chain dehydrogenase reductase Sdr
LI99_RS04285	COG0406	alpha-ribazole phosphatase activity
LI99_RS04295	COG1529	Aldehyde oxidase and xanthine dehydrogenase
LI99_RS04300	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
LI99_RS04305	COG2080	2 iron, 2 sulfur cluster binding
LI99_RS04315	COG2186	Transcriptional regulator
LI99_RS04325	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LI99_RS04330	COG1028	Short-chain dehydrogenase reductase Sdr
LI99_RS04345	COG0459	protein refolding
LI99_RS04360	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
LI99_RS04390	COG1012	belongs to the aldehyde dehydrogenase family
LI99_RS04400	COG2326	polyphosphate kinase activity
LI99_RS04420	COG2186	Transcriptional regulator
LI99_RS04425	COG0477	Major facilitator Superfamily
LI99_RS04440	COG1505	serine-type exopeptidase activity
LI99_RS04455	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LI99_RS04505	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LI99_RS04515	COG2326	polyphosphate kinase activity
LI99_RS04525	COG2733	membrane
LI99_RS04580	COG0812	UDP-N-acetylmuramate dehydrogenase activity
LI99_RS04600	COG0438	transferase activity, transferring glycosyl groups
LI99_RS04615	COG5002	protein histidine kinase activity
LI99_RS04620	COG0745	RESPONSE REGULATOR receiver
LI99_RS04675	COG2030	dehydratase
LI99_RS04690	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
LI99_RS04695	COG0181	hydroxymethylbilane synthase activity
LI99_RS04765	COG2124	cytochrome p450
LI99_RS04770	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LI99_RS04775	COG0406	alpha-ribazole phosphatase activity
LI99_RS04785	COG0785	Cytochrome C biogenesis protein
LI99_RS04795	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LI99_RS04830	COG2201	protein-glutamate methylesterase activity
LI99_RS04835	COG2358	TRAP transporter, solute receptor (TAXI family
LI99_RS04845	COG2197	response regulator
LI99_RS04850	COG0477	Major facilitator Superfamily
LI99_RS04875	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
LI99_RS04880	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LI99_RS04885	COG2070	2-Nitropropane dioxygenase
LI99_RS04890	COG5002	protein histidine kinase activity
LI99_RS04895	COG0745	RESPONSE REGULATOR receiver
LI99_RS05015	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LI99_RS05060	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LI99_RS05065	COG0644	oxidoreductase
LI99_RS05070	COG1309	transcriptional regulator
LI99_RS05115	COG1064	alcohol dehydrogenase
LI99_RS05135	COG3830	Belongs to the UPF0237 family
LI99_RS05135	COG0560	Phosphoserine phosphatase
LI99_RS05145	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LI99_RS05155	COG2364	Membrane
LI99_RS05160	COG1119	ATPase activity
LI99_RS05190	COG1115	amino acid carrier protein
LI99_RS05200	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LI99_RS05205	COG0110	maltose O-acetyltransferase activity
LI99_RS05215	COG1304	FMN binding
LI99_RS05280	COG1028	Short-chain dehydrogenase reductase Sdr
LI99_RS05285	COG1028	Short-chain dehydrogenase reductase Sdr
LI99_RS05305	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
LI99_RS05320	COG0546	phosphoglycolate phosphatase activity
LI99_RS05345	COG0747	negative chemotaxis
LI99_RS05350	COG0601	transmembrane transport
LI99_RS05355	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LI99_RS05360	COG0444	Belongs to the ABC transporter superfamily
LI99_RS05370	COG0154	amidase activity
LI99_RS05385	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
LI99_RS05390	COG0830	nickel cation binding
LI99_RS05395	COG0832	Belongs to the urease beta subunit family
LI99_RS05395	COG0831	urea catabolic process
LI99_RS05400	COG0804	urea catabolic process
LI99_RS05405	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
LI99_RS05410	COG0829	nickel cation binding
LI99_RS05420	COG0318	PFAM AMP-dependent synthetase and ligase
LI99_RS05440	COG1228	amidohydrolase
LI99_RS05445	COG4948	Mandelate Racemase Muconate Lactonizing
LI99_RS05460	COG4977	sequence-specific DNA binding
LI99_RS05475	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
LI99_RS05490	COG0438	transferase activity, transferring glycosyl groups
LI99_RS05495	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
LI99_RS05500	COG0300	oxidoreductase activity
LI99_RS05505	COG2226	methyltransferase
LI99_RS05525	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
LI99_RS05545	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
LI99_RS05585	COG0644	oxidoreductase
LI99_RS05590	COG0142	geranyltranstransferase activity
LI99_RS05595	COG0501	Belongs to the peptidase M48B family
LI99_RS05615	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
LI99_RS05620	COG1396	sequence-specific DNA binding
LI99_RS05635	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LI99_RS05695	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LI99_RS05700	COG1024	Enoyl-CoA hydratase
LI99_RS05710	COG1028	Short-chain dehydrogenase reductase Sdr
LI99_RS05715	COG1012	belongs to the aldehyde dehydrogenase family
LI99_RS05720	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LI99_RS05730	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LI99_RS05735	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LI99_RS05755	COG1666	GTP binding
LI99_RS05785	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LI99_RS05790	COG0798	PFAM Bile acid sodium symporter
LI99_RS05795	COG0640	Transcriptional regulator
LI99_RS05805	COG0640	Transcriptional regulator
LI99_RS05815	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
LI99_RS05825	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
LI99_RS05840	COG1228	amidohydrolase
LI99_RS05845	COG2986	histidine ammonia-lyase
LI99_RS05865	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
LI99_RS05895	COG2304	oxidoreductase activity
LI99_RS05910	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LI99_RS05950	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LI99_RS05955	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LI99_RS06000	COG2133	pyrroloquinoline quinone binding
LI99_RS06060	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LI99_RS06065	COG2188	Transcriptional regulator
LI99_RS06070	COG3119	arylsulfatase activity
LI99_RS06075	COG0187	DNA topoisomerase II activity
LI99_RS06100	COG1116	anion transmembrane transporter activity
LI99_RS06105	COG0659	secondary active sulfate transmembrane transporter activity
LI99_RS06120	COG1061	Type III restriction enzyme res subunit
LI99_RS06195	COG0513	Belongs to the DEAD box helicase family
LI99_RS06260	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
LI99_RS06305	COG3654	unkown
LI99_RS06310	COG4942	peptidase
LI99_RS06330	COG4423	Transcription factor
LI99_RS06335	COG3742	Toxic component of a toxin-antitoxin (TA) module. An RNase
LI99_RS06340	COG0653	protein targeting
LI99_RS06365	COG0129	dihydroxy-acid dehydratase activity
LI99_RS06370	COG1529	Aldehyde oxidase and xanthine dehydrogenase
LI99_RS06370	COG2080	2 iron, 2 sulfur cluster binding
LI99_RS06380	COG2233	PERMEase
LI99_RS06390	COG2351	hydroxyisourate hydrolase activity
LI99_RS06405	COG0402	S-adenosylhomocysteine deaminase activity
LI99_RS06435	COG0667	Aldo Keto reductase
LI99_RS06445	COG1012	belongs to the aldehyde dehydrogenase family
LI99_RS06470	COG1297	OPT oligopeptide transporter protein
LI99_RS06485	COG0668	transmembrane transport
LI99_RS06495	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
LI99_RS06515	COG2271	Major facilitator Superfamily
LI99_RS06525	COG1376	ErfK ybiS ycfS ynhG family protein
LI99_RS06545	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LI99_RS06550	COG1074	ATP-dependent DNA helicase activity
LI99_RS06555	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
LI99_RS06585	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LI99_RS06590	COG1959	2 iron, 2 sulfur cluster binding
LI99_RS06595	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LI99_RS06595	COG1017	nitric oxide dioxygenase activity
LI99_RS06610	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LI99_RS06620	COG2030	dehydratase
LI99_RS06635	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LI99_RS06645	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
LI99_RS06650	COG0081	regulation of translation
LI99_RS06655	COG4941	Belongs to the sigma-70 factor family
LI99_RS06665	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LI99_RS06670	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LI99_RS06695	COG2318	DinB family
LI99_RS06730	COG1940	carbohydrate kinase activity
LI99_RS06735	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
LI99_RS06740	COG0222	ribosome binding
LI99_RS06750	COG0085	RNA polymerase activity
LI99_RS06755	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
LI99_RS06765	COG1063	alcohol dehydrogenase
LI99_RS06770	COG1482	cell wall glycoprotein biosynthetic process
LI99_RS06780	COG1172	Belongs to the binding-protein-dependent transport system permease family
LI99_RS06795	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LI99_RS06805	COG1105	Belongs to the carbohydrate kinase PfkB family
LI99_RS06810	COG0579	oxidoreductase
LI99_RS06845	COG1960	acyl-CoA dehydrogenase activity
LI99_RS06860	COG1024	Enoyl-CoA hydratase
LI99_RS06870	COG1454	alcohol dehydrogenase
LI99_RS06895	COG1309	transcriptional regulator
LI99_RS06900	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
LI99_RS06905	COG0049	tRNA binding
LI99_RS06915	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LI99_RS06955	COG2235	arginine
LI99_RS06970	COG0531	amino acid
LI99_RS06975	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LI99_RS06980	COG1834	amidinotransferase
LI99_RS06985	COG1522	sequence-specific DNA binding
LI99_RS07020	COG0535	radical SAM domain protein
LI99_RS07045	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
LI99_RS07050	COG0477	Major facilitator Superfamily
LI99_RS07085	COG0051	transcription antitermination factor activity, RNA binding
LI99_RS07090	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
LI99_RS07095	COG0088	Forms part of the polypeptide exit tunnel
LI99_RS07100	COG0089	rRNA binding
LI99_RS07105	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
LI99_RS07110	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
LI99_RS07115	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
LI99_RS07120	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
LI99_RS07125	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
LI99_RS07130	COG0255	Belongs to the universal ribosomal protein uL29 family
LI99_RS07135	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
LI99_RS07150	COG0659	secondary active sulfate transmembrane transporter activity
LI99_RS07170	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LI99_RS07175	COG3069	C4-dicarboxylate transmembrane transporter activity
LI99_RS07210	COG1012	belongs to the aldehyde dehydrogenase family
LI99_RS07220	COG0405	Gamma-glutamyltransferase
LI99_RS07230	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
LI99_RS07235	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
LI99_RS07240	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
LI99_RS07245	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
LI99_RS07250	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
LI99_RS07255	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
LI99_RS07260	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
LI99_RS07265	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
LI99_RS07270	COG1841	ribosomal large subunit assembly
LI99_RS07280	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LI99_RS07285	COG0616	signal peptide processing
LI99_RS07295	COG1280	lysine exporter protein (LysE YggA)
LI99_RS07300	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
LI99_RS07305	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
LI99_RS07310	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
LI99_RS07315	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
LI99_RS07325	COG0563	adenylate kinase activity
LI99_RS07355	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LI99_RS07360	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LI99_RS07375	COG2197	response regulator
LI99_RS07380	COG0560	Phosphoserine phosphatase
LI99_RS07380	COG3830	Belongs to the UPF0237 family
LI99_RS07390	COG1960	acyl-CoA dehydrogenase activity
LI99_RS07400	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LI99_RS07430	COG5006	permease, DMT superfamily
LI99_RS07450	COG1309	transcriptional regulator
LI99_RS07460	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
LI99_RS07465	COG1088	dTDP-glucose 4,6-dehydratase activity
LI99_RS07480	COG3852	Histidine kinase
LI99_RS07490	COG2268	Band 7 protein
LI99_RS07500	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LI99_RS07505	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LI99_RS07510	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
LI99_RS07515	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
LI99_RS07520	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
LI99_RS07525	COG0202	RNA polymerase activity
LI99_RS07530	COG0203	ribosomal protein L17
LI99_RS07575	COG1404	Belongs to the peptidase S8 family
LI99_RS07595	COG4842	Belongs to the WXG100 family
LI99_RS07600	COG4842	Belongs to the WXG100 family
LI99_RS07605	COG0513	Belongs to the DEAD box helicase family
LI99_RS07665	COG0531	amino acid
LI99_RS07670	COG4303	Ethanolamine ammonia lyase large subunit
LI99_RS07685	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
LI99_RS07690	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
LI99_RS07700	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LI99_RS07715	COG0583	DNA-binding transcription factor activity
LI99_RS07720	COG1028	Short-chain dehydrogenase reductase Sdr
LI99_RS07735	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LI99_RS07745	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LI99_RS07750	COG0596	Alpha beta hydrolase
LI99_RS07770	COG0076	glutamate decarboxylase activity
LI99_RS07775	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LI99_RS07795	COG0456	acetyltransferase
LI99_RS07800	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
LI99_RS07810	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
LI99_RS07815	COG0459	protein refolding
LI99_RS07860	COG1024	Enoyl-CoA hydratase
LI99_RS07910	COG0516	GMP reductase activity
LI99_RS07945	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LI99_RS07945	COG0519	Catalyzes the synthesis of GMP from XMP
LI99_RS07955	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LI99_RS07960	COG0765	amino acid transport
LI99_RS08015	COG4221	oxidoreductase activity
LI99_RS08035	COG1028	Short-chain dehydrogenase reductase Sdr
LI99_RS08055	COG0587	DNA-directed DNA polymerase activity
LI99_RS08075	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
LI99_RS08080	COG5002	protein histidine kinase activity
LI99_RS08085	COG2018	Roadblock/LC7 domain
LI99_RS08100	COG1357	PFAM Pentapeptide repeats (8 copies)
LI99_RS08105	COG0842	Transport permease protein
LI99_RS08105	COG1131	(ABC) transporter
LI99_RS08105	COG1716	ATPase activity
LI99_RS08125	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LI99_RS08155	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LI99_RS08160	COG2873	o-acetylhomoserine
LI99_RS08180	COG0708	Exodeoxyribonuclease III
LI99_RS08190	COG1295	ribonuclease BN
LI99_RS08205	COG1686	Belongs to the peptidase S11 family
LI99_RS08210	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LI99_RS08230	COG1595	DNA-templated transcription, initiation
LI99_RS08240	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LI99_RS08245	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
LI99_RS08260	COG2009	succinate dehydrogenase
LI99_RS08305	COG2072	flavoprotein involved in K transport
LI99_RS08310	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
LI99_RS08345	COG1595	DNA-templated transcription, initiation
LI99_RS08350	COG2197	response regulator
LI99_RS08355	COG1595	DNA-templated transcription, initiation
LI99_RS08360	COG1053	succinate dehydrogenase
LI99_RS08370	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LI99_RS08380	COG3180	Ammonia monooxygenase
LI99_RS08410	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
LI99_RS08410	COG1473	amidohydrolase
LI99_RS08425	COG4214	carbohydrate transport
LI99_RS08435	COG1609	Transcriptional regulator
LI99_RS08445	COG1172	Belongs to the binding-protein-dependent transport system permease family
LI99_RS08455	COG1879	ABC-type sugar transport system periplasmic component
LI99_RS08470	COG2160	L-arabinose isomerase activity
LI99_RS08485	COG2826	transposase and inactivated derivatives, IS30 family
LI99_RS08490	COG2801	Transposase and inactivated derivatives
LI99_RS08550	COG3547	Transposase (IS116 IS110 IS902 family)
LI99_RS08580	COG0564	pseudouridine synthase activity
LI99_RS08590	COG1028	Short-chain dehydrogenase reductase Sdr
LI99_RS08600	COG1309	transcriptional regulator
LI99_RS08625	COG0812	UDP-N-acetylmuramate dehydrogenase activity
LI99_RS08630	COG1595	DNA-templated transcription, initiation
LI99_RS08640	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LI99_RS08645	COG0667	Aldo Keto reductase
LI99_RS08670	COG1201	RNA secondary structure unwinding
LI99_RS08685	COG1028	Short-chain dehydrogenase reductase Sdr
LI99_RS08690	COG1012	belongs to the aldehyde dehydrogenase family
LI99_RS08695	COG1522	sequence-specific DNA binding
LI99_RS08735	COG2890	protein-(glutamine-N5) methyltransferase activity
LI99_RS08760	COG1234	tRNA 3'-trailer cleavage
LI99_RS08790	COG1028	Short-chain dehydrogenase reductase Sdr
LI99_RS08840	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LI99_RS08850	COG1063	alcohol dehydrogenase
LI99_RS08855	COG0445	tRNA wobble uridine modification
LI99_RS08865	COG0477	Major facilitator Superfamily
LI99_RS08910	COG4770	biotin carboxylase activity
LI99_RS08930	COG0424	maF-like protein
LI99_RS08940	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LI99_RS08970	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
LI99_RS08975	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
LI99_RS08995	COG1316	TRANSCRIPTIONal
LI99_RS09000	COG1091	dTDP-4-dehydrorhamnose reductase activity
LI99_RS09010	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
LI99_RS09020	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
LI99_RS09020	COG0778	Nitroreductase
LI99_RS09025	COG0391	Required for morphogenesis under gluconeogenic growth conditions
LI99_RS09045	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LI99_RS09055	COG1482	cell wall glycoprotein biosynthetic process
LI99_RS09060	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LI99_RS09065	COG0531	amino acid
LI99_RS09070	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LI99_RS09090	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
LI99_RS09100	COG2860	membrane
LI99_RS09110	COG0437	4 iron, 4 sulfur cluster binding
LI99_RS09115	COG3383	formate dehydrogenase (NAD+) activity
LI99_RS09115	COG0243	molybdopterin cofactor binding
LI99_RS09120	COG0243	molybdopterin cofactor binding
LI99_RS09120	COG3383	formate dehydrogenase (NAD+) activity
LI99_RS09125	COG3276	selenocysteine insertion sequence binding
LI99_RS09130	COG1921	L-seryl-tRNASec selenium transferase activity
LI99_RS09140	COG0709	Synthesizes selenophosphate from selenide and ATP
LI99_RS09145	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LI99_RS09145	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
LI99_RS09150	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LI99_RS09250	COG0745	RESPONSE REGULATOR receiver
LI99_RS09255	COG5002	protein histidine kinase activity
LI99_RS09260	COG5401	PFAM Sporulation and spore germination
LI99_RS09270	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
LI99_RS09280	COG0653	protein targeting
LI99_RS09295	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LI99_RS09320	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
LI99_RS09325	COG1162	GTPase activity
LI99_RS09330	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
LI99_RS09335	COG2135	peptidase activity
LI99_RS09340	COG2890	protein-(glutamine-N5) methyltransferase activity
LI99_RS09345	COG2226	methyltransferase
LI99_RS09350	COG1028	Short-chain dehydrogenase reductase Sdr
LI99_RS09355	COG0583	DNA-binding transcription factor activity
LI99_RS09360	COG0183	Belongs to the thiolase family
LI99_RS09365	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LI99_RS09390	COG0583	DNA-binding transcription factor activity
LI99_RS09395	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LI99_RS09400	COG1960	acyl-CoA dehydrogenase activity
LI99_RS09405	COG1960	acyl-CoA dehydrogenase activity
LI99_RS09420	COG4638	Rieske (2fe-2S)
LI99_RS09425	COG0583	DNA-binding transcription factor activity
LI99_RS09430	COG4948	Mandelate Racemase Muconate Lactonizing
LI99_RS09435	COG3485	protocatechuate 3,4-dioxygenase
LI99_RS09445	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
LI99_RS09450	COG1595	DNA-templated transcription, initiation
LI99_RS09455	COG5662	AntiSigma factor
LI99_RS09465	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
LI99_RS09480	COG1597	lipid kinase activity
LI99_RS09485	COG3012	SEC-C Motif Domain Protein
LI99_RS09490	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
LI99_RS09510	COG0406	alpha-ribazole phosphatase activity
LI99_RS09520	COG0631	protein serine/threonine phosphatase activity
LI99_RS09530	COG0513	Belongs to the DEAD box helicase family
LI99_RS09570	COG3695	enzyme binding
LI99_RS09575	COG0596	Alpha beta hydrolase
LI99_RS09600	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LI99_RS09640	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LI99_RS09655	COG3480	Lon protease (S16) C-terminal proteolytic domain
LI99_RS09660	COG1615	UPF0182 protein
LI99_RS09710	COG0789	Transcriptional regulator
LI99_RS09715	COG3284	Transcriptional regulator
LI99_RS09720	COG3350	monooxygenase activity
LI99_RS09725	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LI99_RS09750	COG1063	alcohol dehydrogenase
LI99_RS09755	COG0459	protein refolding
LI99_RS09775	COG0318	PFAM AMP-dependent synthetase and ligase
LI99_RS09780	COG0477	Major facilitator Superfamily
LI99_RS09785	COG0596	Alpha beta hydrolase
LI99_RS09790	COG0583	DNA-binding transcription factor activity
LI99_RS09795	COG0473	3-isopropylmalate dehydrogenase activity
LI99_RS09830	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
LI99_RS09840	COG1802	Transcriptional regulator
LI99_RS09855	COG0596	Alpha beta hydrolase
LI99_RS09870	COG0477	Major facilitator Superfamily
LI99_RS09905	COG1802	Transcriptional regulator
LI99_RS09915	COG1609	Transcriptional regulator
LI99_RS09920	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
LI99_RS09925	COG1028	Short-chain dehydrogenase reductase Sdr
LI99_RS09965	COG2610	gluconate transmembrane transporter activity
LI99_RS09970	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LI99_RS09975	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LI99_RS09980	COG1414	Transcriptional regulator
LI99_RS10005	COG1309	transcriptional regulator
LI99_RS10010	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
LI99_RS10040	COG2072	flavoprotein involved in K transport
LI99_RS10070	COG0477	Major facilitator Superfamily
LI99_RS10085	COG1063	alcohol dehydrogenase
LI99_RS10090	COG1024	Enoyl-CoA hydratase
LI99_RS10115	COG0713	ATP synthesis coupled electron transport
LI99_RS10125	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LI99_RS10130	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
LI99_RS10135	COG1034	ATP synthesis coupled electron transport
LI99_RS10150	COG0649	NAD binding
LI99_RS10155	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LI99_RS10160	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LI99_RS10185	COG2226	methyltransferase
LI99_RS10200	COG1960	acyl-CoA dehydrogenase activity
LI99_RS10210	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LI99_RS10215	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LI99_RS10230	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
LI99_RS10240	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
LI99_RS10250	COG1960	acyl-CoA dehydrogenase activity
LI99_RS10265	COG0483	inositol monophosphate 1-phosphatase activity
LI99_RS10280	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
LI99_RS10285	COG0668	transmembrane transport
LI99_RS10295	COG2884	Cell division ATP-binding protein ftsE
LI99_RS10305	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
LI99_RS10325	COG0730	response to heat
LI99_RS10335	COG0179	Fumarylacetoacetate (FAA) hydrolase
LI99_RS10355	COG1116	anion transmembrane transporter activity
LI99_RS10365	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LI99_RS10405	COG1605	Chorismate mutase
LI99_RS10430	COG1263	PTS System
LI99_RS10430	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LI99_RS10430	COG2190	(PTS) system
LI99_RS10435	COG2190	(PTS) system
LI99_RS10440	COG0363	glucosamine-6-phosphate deaminase activity
LI99_RS10445	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
LI99_RS10455	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LI99_RS10455	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
LI99_RS10460	COG1461	Dihydroxyacetone kinase
LI99_RS10465	COG2376	Dihydroxyacetone kinase
LI99_RS10470	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LI99_RS10475	COG1414	Transcriptional regulator
LI99_RS10500	COG0318	PFAM AMP-dependent synthetase and ligase
LI99_RS10520	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LI99_RS10530	COG2814	Major facilitator Superfamily
LI99_RS10625	COG3220	belongs to the UPF0276 family
LI99_RS10645	COG1012	belongs to the aldehyde dehydrogenase family
LI99_RS10650	COG2186	Transcriptional regulator
LI99_RS10655	COG3959	Transketolase, thiamine diphosphate binding domain
LI99_RS10660	COG3958	Transketolase
LI99_RS10665	COG0006	proline dipeptidase activity
LI99_RS10685	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LI99_RS10695	COG2186	Transcriptional regulator
LI99_RS10700	COG3973	AAA domain
LI99_RS10710	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LI99_RS10715	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LI99_RS10735	COG1309	transcriptional regulator
LI99_RS10785	COG1960	acyl-CoA dehydrogenase activity
LI99_RS10795	COG0789	Transcriptional regulator
LI99_RS10840	COG2072	flavoprotein involved in K transport
LI99_RS10850	COG1028	Short-chain dehydrogenase reductase Sdr
LI99_RS10855	COG1960	acyl-CoA dehydrogenase activity
LI99_RS10865	COG0183	Belongs to the thiolase family
LI99_RS10870	COG1960	acyl-CoA dehydrogenase activity
LI99_RS10880	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LI99_RS10890	COG4221	oxidoreductase activity
LI99_RS10910	COG0318	PFAM AMP-dependent synthetase and ligase
LI99_RS10915	COG1024	Enoyl-CoA hydratase
LI99_RS10920	COG1024	Enoyl-CoA hydratase
LI99_RS10935	COG1024	Enoyl-CoA hydratase
LI99_RS10955	COG1024	Enoyl-CoA hydratase
LI99_RS10960	COG1028	Short-chain dehydrogenase reductase Sdr
LI99_RS10965	COG1024	Enoyl-CoA hydratase
LI99_RS10990	COG1960	acyl-CoA dehydrogenase activity
LI99_RS11000	COG0183	Belongs to the thiolase family
LI99_RS11005	COG0243	molybdopterin cofactor binding
LI99_RS11020	COG2124	cytochrome p450
LI99_RS11025	COG1012	belongs to the aldehyde dehydrogenase family
LI99_RS11035	COG1335	isochorismatase
LI99_RS11050	COG2318	DinB family
LI99_RS11080	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LI99_RS11090	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LI99_RS11105	COG1966	Carbon starvation protein
LI99_RS11145	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
LI99_RS11145	COG0316	Belongs to the HesB IscA family
LI99_RS11165	COG0375	protein maturation
LI99_RS11175	COG0298	carbon dioxide binding
LI99_RS11180	COG0409	Hydrogenase expression formation protein
LI99_RS11190	COG1793	dna ligase
LI99_RS11205	COG0028	Belongs to the TPP enzyme family
LI99_RS11295	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LI99_RS11335	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LI99_RS11340	COG0644	oxidoreductase
LI99_RS11345	COG1309	transcriptional regulator
LI99_RS11385	COG1064	alcohol dehydrogenase
LI99_RS11405	COG3830	Belongs to the UPF0237 family
LI99_RS11405	COG0560	Phosphoserine phosphatase
LI99_RS11415	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LI99_RS11420	COG2364	Membrane
LI99_RS11425	COG1119	ATPase activity
LI99_RS11455	COG1115	amino acid carrier protein
LI99_RS11460	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LI99_RS11465	COG0110	maltose O-acetyltransferase activity
LI99_RS11475	COG1304	FMN binding
LI99_RS11490	COG1819	glycosyl
LI99_RS11505	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
LI99_RS11540	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LI99_RS11550	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
LI99_RS11560	COG0778	Nitroreductase
LI99_RS11560	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
LI99_RS11580	COG0482	sulfurtransferase activity
LI99_RS11590	COG0318	PFAM AMP-dependent synthetase and ligase
LI99_RS11600	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LI99_RS11610	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LI99_RS11625	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LI99_RS11655	COG0440	acetolactate synthase activity
LI99_RS11660	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
LI99_RS11665	COG0655	NAD(P)H dehydrogenase (quinone) activity
LI99_RS11685	COG0473	3-isopropylmalate dehydrogenase activity
LI99_RS11690	COG2271	Major facilitator Superfamily
LI99_RS11700	COG0179	Fumarylacetoacetate (FAA) hydrolase
LI99_RS11705	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LI99_RS11725	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
LI99_RS11730	COG0066	3-isopropylmalate dehydratase activity
LI99_RS11735	COG0776	regulation of translation
LI99_RS11740	COG0494	nUDIX hydrolase
LI99_RS11740	COG0406	alpha-ribazole phosphatase activity
LI99_RS11745	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
LI99_RS11750	COG1920	GTP binding
LI99_RS11760	COG0626	cystathionine gamma-synthase activity
LI99_RS11765	COG1181	Belongs to the D-alanine--D-alanine ligase family
LI99_RS11785	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LI99_RS11800	COG1461	Dihydroxyacetone kinase
LI99_RS11825	COG0656	L-ascorbic acid biosynthetic process
LI99_RS11830	COG0656	L-ascorbic acid biosynthetic process
LI99_RS11835	COG0657	acetylesterase activity
LI99_RS11850	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
LI99_RS11855	COG0742	ribosomal rna small subunit methyltransferase
LI99_RS11860	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
LI99_RS11870	COG3599	regulation of cell shape
LI99_RS11880	COG0571	ribonuclease III activity
LI99_RS11885	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LI99_RS11900	COG1254	Belongs to the acylphosphatase family
LI99_RS11925	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
LI99_RS11935	COG0667	Aldo Keto reductase
LI99_RS11950	COG1686	Belongs to the peptidase S11 family
LI99_RS11955	COG1686	Belongs to the peptidase S11 family
LI99_RS11965	COG0228	four-way junction DNA binding
LI99_RS11975	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
LI99_RS11990	COG0335	large ribosomal subunit rRNA binding
LI99_RS12000	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LI99_RS12015	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
LI99_RS12055	COG1802	Transcriptional regulator
LI99_RS12080	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LI99_RS12095	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LI99_RS12120	COG1960	acyl-CoA dehydrogenase activity
LI99_RS12130	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LI99_RS12160	COG0667	Aldo Keto reductase
LI99_RS12175	COG0179	Fumarylacetoacetate (FAA) hydrolase
LI99_RS12200	COG1414	Transcriptional regulator
LI99_RS12210	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LI99_RS12220	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
LI99_RS12240	COG0277	FAD linked oxidase domain protein
LI99_RS12240	COG0247	lactate metabolic process
LI99_RS12245	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LI99_RS12250	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LI99_RS12255	COG0006	proline dipeptidase activity
LI99_RS12265	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LI99_RS12270	COG0154	amidase activity
LI99_RS12285	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LI99_RS12290	COG4176	ABC-type proline glycine betaine transport system permease component
LI99_RS12305	COG0066	3-isopropylmalate dehydratase activity
LI99_RS12310	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
LI99_RS12325	COG0792	nuclease activity
LI99_RS12360	COG4974	Belongs to the 'phage' integrase family
LI99_RS12380	COG0052	Belongs to the universal ribosomal protein uS2 family
LI99_RS12385	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
LI99_RS12390	COG0154	amidase activity
LI99_RS12405	COG1136	(ABC) transporter
LI99_RS12425	COG1929	Belongs to the glycerate kinase type-1 family
LI99_RS12440	COG2186	Transcriptional regulator
LI99_RS12445	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
LI99_RS12465	COG1028	Short-chain dehydrogenase reductase Sdr
LI99_RS12485	COG0528	UMP kinase activity
LI99_RS12490	COG0233	cytoplasmic translational termination
LI99_RS12510	COG0820	rRNA (adenine-C2-)-methyltransferase activity
LI99_RS12520	COG2390	Transcriptional regulator
LI99_RS12525	COG1028	Short-chain dehydrogenase reductase Sdr
LI99_RS12530	COG2271	Major facilitator Superfamily
LI99_RS12535	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LI99_RS12560	COG1472	Belongs to the glycosyl hydrolase 3 family
LI99_RS12565	COG1309	transcriptional regulator
LI99_RS12620	COG0657	acetylesterase activity
LI99_RS12630	COG2233	PERMEase
LI99_RS12660	COG0415	Belongs to the DNA photolyase family
LI99_RS12670	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
LI99_RS12675	COG0750	zinc metalloprotease
LI99_RS12720	COG1492	cobalamin metabolic process
LI99_RS12730	COG2207	Transcriptional regulator
LI99_RS12730	COG1917	Cupin 2, conserved barrel domain protein
LI99_RS12750	COG0367	asparagine synthase
LI99_RS12760	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
LI99_RS12765	COG1012	belongs to the aldehyde dehydrogenase family
LI99_RS12770	COG1028	Short-chain dehydrogenase reductase Sdr
LI99_RS12775	COG2186	Transcriptional regulator
LI99_RS12780	COG1414	Transcriptional regulator
LI99_RS12785	COG3485	protocatechuate 3,4-dioxygenase
LI99_RS12790	COG3485	protocatechuate 3,4-dioxygenase
LI99_RS12795	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LI99_RS12800	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LI99_RS12805	COG2186	Transcriptional regulator
LI99_RS12815	COG0310	cobalt ion transport
LI99_RS12830	COG1122	ATPase activity
LI99_RS12845	COG0579	oxidoreductase
LI99_RS12870	COG1648	precorrin-2 dehydrogenase activity
LI99_RS12870	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LI99_RS12885	COG0442	prolyl-tRNA aminoacylation
LI99_RS12900	COG0779	Required for maturation of 30S ribosomal subunits
LI99_RS12905	COG0195	Participates in both transcription termination and antitermination
LI99_RS12910	COG0481	GTPase activity
LI99_RS12915	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
LI99_RS12920	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
LI99_RS12935	COG1116	anion transmembrane transporter activity
LI99_RS12945	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LI99_RS12950	COG1609	Transcriptional regulator
LI99_RS12955	COG0673	inositol 2-dehydrogenase activity
LI99_RS12975	COG1024	Enoyl-CoA hydratase
LI99_RS13000	COG3547	Transposase (IS116 IS110 IS902 family)
LI99_RS13005	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
LI99_RS13010	COG2977	Belongs to the P-Pant transferase superfamily
LI99_RS13025	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LI99_RS13040	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
LI99_RS13050	COG1185	polyribonucleotide nucleotidyltransferase activity
LI99_RS13065	COG0686	Belongs to the AlaDH PNT family
LI99_RS13070	COG1522	sequence-specific DNA binding
LI99_RS13085	COG1403	HNH endonuclease
LI99_RS13090	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
LI99_RS13110	COG2301	Belongs to the HpcH HpaI aldolase family
LI99_RS13120	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
LI99_RS13125	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
LI99_RS13135	COG2801	Transposase and inactivated derivatives
LI99_RS13140	COG2826	transposase and inactivated derivatives, IS30 family
LI99_RS13145	COG2963	transposase activity
LI99_RS13160	COG3214	Protein conserved in bacteria
LI99_RS13165	COG0531	amino acid
LI99_RS13170	COG2267	carboxylic ester hydrolase activity
LI99_RS13180	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
LI99_RS13185	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LI99_RS13190	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
LI99_RS13210	COG1674	ftsk spoiiie
LI99_RS13215	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
LI99_RS13225	COG1546	Belongs to the CinA family
LI99_RS13225	COG1058	Belongs to the CinA family
LI99_RS13230	COG1396	sequence-specific DNA binding
LI99_RS13235	COG1842	Phage shock protein A
LI99_RS13250	COG4308	Limonene-1,2-epoxide hydrolase catalytic domain
LI99_RS13275	COG0298	carbon dioxide binding
LI99_RS13290	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
LI99_RS13310	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
LI99_RS13350	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
LI99_RS13365	COG0375	protein maturation
LI99_RS13370	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
LI99_RS13375	COG2137	regulation of response to DNA damage stimulus
LI99_RS13380	COG0765	amino acid transport
LI99_RS13385	COG0765	amino acid transport
LI99_RS13390	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LI99_RS13395	COG1126	abc transporter atp-binding protein
LI99_RS13400	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LI99_RS13410	COG1196	nuclear chromosome segregation
LI99_RS13415	COG0697	spore germination
LI99_RS13425	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
LI99_RS13430	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
LI99_RS13435	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LI99_RS13455	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LI99_RS13465	COG1388	LysM domain
LI99_RS13470	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
LI99_RS13555	COG0483	inositol monophosphate 1-phosphatase activity
LI99_RS13575	COG0756	dUTP diphosphatase activity
LI99_RS13605	COG0569	domain protein
LI99_RS13610	COG0531	amino acid
LI99_RS13615	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LI99_RS13625	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
LI99_RS13630	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LI99_RS13640	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
LI99_RS13650	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
LI99_RS13660	COG3253	May function as heme-dependent peroxidase
LI99_RS13670	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LI99_RS13715	COG2205	protein histidine kinase activity
LI99_RS13720	COG2186	Transcriptional regulator
LI99_RS13725	COG2807	transmembrane transport
LI99_RS13740	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LI99_RS13750	COG0431	NADPH-dependent FMN reductase
LI99_RS13790	COG0300	oxidoreductase activity
LI99_RS13800	COG2814	Major facilitator Superfamily
LI99_RS13815	COG4585	Histidine kinase
LI99_RS13935	COG0243	molybdopterin cofactor binding
LI99_RS13960	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LI99_RS13975	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LI99_RS13985	COG0747	negative chemotaxis
LI99_RS13995	COG1733	regulation of RNA biosynthetic process
LI99_RS14010	COG1028	Short-chain dehydrogenase reductase Sdr
LI99_RS14015	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LI99_RS14020	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LI99_RS14045	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
LI99_RS14085	COG1053	succinate dehydrogenase
LI99_RS14095	COG1053	succinate dehydrogenase
LI99_RS14145	COG1960	acyl-CoA dehydrogenase activity
LI99_RS14150	COG1024	Enoyl-CoA hydratase
LI99_RS14160	COG1063	alcohol dehydrogenase
LI99_RS14165	COG0318	PFAM AMP-dependent synthetase and ligase
LI99_RS14170	COG2072	flavoprotein involved in K transport
LI99_RS14175	COG1028	Short-chain dehydrogenase reductase Sdr
LI99_RS14200	COG1414	Transcriptional regulator
LI99_RS14205	COG0346	lactoylglutathione lyase activity
LI99_RS14220	COG2072	flavoprotein involved in K transport
LI99_RS14225	COG4221	oxidoreductase activity
LI99_RS14230	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LI99_RS14245	COG4221	oxidoreductase activity
LI99_RS14275	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LI99_RS14280	COG1733	regulation of RNA biosynthetic process
LI99_RS14290	COG0246	Mannitol dehydrogenase
LI99_RS14315	COG0477	Major facilitator Superfamily
LI99_RS14320	COG1063	alcohol dehydrogenase
LI99_RS14330	COG2205	protein histidine kinase activity
LI99_RS14335	COG0745	RESPONSE REGULATOR receiver
LI99_RS14345	COG1028	Short-chain dehydrogenase reductase Sdr
LI99_RS14350	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
LI99_RS14355	COG0667	Aldo Keto reductase
LI99_RS14370	COG1028	Short-chain dehydrogenase reductase Sdr
LI99_RS14380	COG1174	glycine betaine transport
LI99_RS14410	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LI99_RS14420	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LI99_RS14425	COG1560	Kdo2-lipid A biosynthetic process
LI99_RS14430	COG0438	transferase activity, transferring glycosyl groups
LI99_RS14440	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
LI99_RS14445	COG1946	Acyl-CoA thioesterase
LI99_RS14450	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
LI99_RS14455	COG0217	transcriptional regulatory protein
LI99_RS14460	COG0702	epimerase
LI99_RS14470	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
LI99_RS14475	COG0632	four-way junction helicase activity
LI99_RS14480	COG2255	four-way junction helicase activity
LI99_RS14490	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
LI99_RS14515	COG0477	Major facilitator Superfamily
LI99_RS14525	COG1609	Transcriptional regulator
LI99_RS14535	COG3320	Male sterility
LI99_RS14535	COG1022	Amp-dependent synthetase and ligase
LI99_RS14565	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LI99_RS14570	COG0747	negative chemotaxis
LI99_RS14575	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LI99_RS14580	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LI99_RS14585	COG2271	Major facilitator Superfamily
LI99_RS14590	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LI99_RS14625	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LI99_RS14635	COG0124	histidyl-tRNA synthetase
LI99_RS14665	COG0683	leucine binding
LI99_RS14675	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LI99_RS14680	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
LI99_RS14680	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
LI99_RS14695	COG3153	acetyltransferase
LI99_RS14695	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LI99_RS14700	COG1609	Transcriptional regulator
LI99_RS14710	COG2814	Major facilitator Superfamily
LI99_RS14715	COG1960	acyl-CoA dehydrogenase activity
LI99_RS14720	COG1960	acyl-CoA dehydrogenase activity
LI99_RS14760	COG2272	Belongs to the type-B carboxylesterase lipase family
LI99_RS14770	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
LI99_RS14785	COG1454	alcohol dehydrogenase
LI99_RS14810	COG2072	flavoprotein involved in K transport
LI99_RS14815	COG0183	Belongs to the thiolase family
LI99_RS14820	COG1733	regulation of RNA biosynthetic process
LI99_RS14875	COG0432	Pfam Uncharacterised protein family UPF0047
LI99_RS14880	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LI99_RS14885	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
LI99_RS14895	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LI99_RS14905	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
LI99_RS14910	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
LI99_RS14915	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
LI99_RS14925	COG0006	proline dipeptidase activity
LI99_RS14930	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LI99_RS14935	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LI99_RS14965	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
LI99_RS14970	COG0540	Belongs to the ATCase OTCase family
LI99_RS14985	COG0505	Belongs to the CarA family
LI99_RS14995	COG0284	orotidine-5'-phosphate decarboxylase activity
LI99_RS15015	COG1758	RNA polymerase activity
LI99_RS15025	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
LI99_RS15035	COG2011	ABC-type metal ion transport system permease component
LI99_RS15040	COG1464	Belongs to the NlpA lipoprotein family
LI99_RS15045	COG0657	acetylesterase activity
LI99_RS15065	COG1704	LemA family
LI99_RS15070	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LI99_RS15095	COG0477	Major facilitator Superfamily
LI99_RS15110	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LI99_RS15110	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LI99_RS15115	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
LI99_RS15140	COG0322	excinuclease ABC activity
LI99_RS15145	COG1660	Displays ATPase and GTPase activities
LI99_RS15155	COG1481	regulation of sporulation
LI99_RS15165	COG1090	epimerase
LI99_RS15170	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LI99_RS15175	COG0126	phosphoglycerate kinase activity
LI99_RS15180	COG0149	triose-phosphate isomerase activity
LI99_RS15195	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
LI99_RS15200	COG1172	Belongs to the binding-protein-dependent transport system permease family
LI99_RS15205	COG1129	ABC transporter
LI99_RS15210	COG2390	Transcriptional regulator
LI99_RS15220	COG1063	alcohol dehydrogenase
LI99_RS15225	COG1879	ABC-type sugar transport system periplasmic component
LI99_RS15230	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
LI99_RS15255	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LI99_RS15270	COG0109	protoheme IX farnesyltransferase activity
LI99_RS15285	COG3842	ATPase activity
LI99_RS15290	COG0395	ABC-type sugar transport system, permease component
LI99_RS15305	COG1028	Short-chain dehydrogenase reductase Sdr
LI99_RS15310	COG1070	Carbohydrate kinase
LI99_RS15315	COG0434	BtpA family
LI99_RS15320	COG0483	inositol monophosphate 1-phosphatase activity
LI99_RS15325	COG1349	DNA-binding transcription factor activity
LI99_RS15365	COG0396	ATPase activity
LI99_RS15380	COG2151	metal-sulfur cluster biosynthetic enzyme
LI99_RS15410	COG2124	cytochrome p450
LI99_RS15430	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LI99_RS15440	COG0488	(ABC) transporter
LI99_RS15450	COG1309	transcriptional regulator
LI99_RS15455	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
LI99_RS15465	COG3883	PFAM NLP P60 protein
LI99_RS15465	COG0791	NLP P60 protein
LI99_RS15475	COG0714	Associated with various cellular activities
LI99_RS15485	COG2304	oxidoreductase activity
LI99_RS15490	COG1028	Short-chain dehydrogenase reductase Sdr
LI99_RS15495	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
LI99_RS15500	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
LI99_RS15550	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LI99_RS15580	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
LI99_RS15585	COG2501	S4 domain
LI99_RS15600	COG0252	asparaginase activity
LI99_RS15605	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
LI99_RS15680	COG0156	8-amino-7-oxononanoate synthase activity
LI99_RS15685	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
LI99_RS15705	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
LI99_RS15725	COG0494	nUDIX hydrolase
LI99_RS15730	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
LI99_RS15750	COG1280	lysine exporter protein (LysE YggA)
LI99_RS15765	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LI99_RS15770	COG0131	Imidazoleglycerol-phosphate dehydratase
LI99_RS15775	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
LI99_RS15780	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
LI99_RS15785	COG0483	inositol monophosphate 1-phosphatase activity
LI99_RS15790	COG0107	imidazoleglycerol-phosphate synthase activity
LI99_RS15795	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
LI99_RS15810	COG1119	ATPase activity
LI99_RS15820	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LI99_RS15830	COG0134	indole-3-glycerol-phosphate synthase activity
LI99_RS15860	COG0070	glutamate synthase
LI99_RS15860	COG0069	glutamate synthase activity
LI99_RS15860	COG0067	glutamate synthase
LI99_RS15875	COG1946	Acyl-CoA thioesterase
LI99_RS15885	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
LI99_RS15890	COG4988	ABC transporter
LI99_RS15895	COG1294	oxidase, subunit
LI99_RS15900	COG1271	oxidase subunit
LI99_RS15910	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LI99_RS15945	COG0783	Belongs to the Dps family
LI99_RS15995	COG1742	UPF0060 membrane protein
LI99_RS16015	COG1070	Carbohydrate kinase
LI99_RS16035	COG1070	Carbohydrate kinase
LI99_RS16040	COG1028	Short-chain dehydrogenase reductase Sdr
LI99_RS16050	COG1063	alcohol dehydrogenase
LI99_RS16055	COG1653	transport
LI99_RS16060	COG1175	transmembrane transport
LI99_RS16070	COG3842	ATPase activity
LI99_RS16075	COG3842	ATPase activity
LI99_RS16080	COG2376	Dihydroxyacetone kinase
LI99_RS16085	COG0698	ribose 5-phosphate isomerase
LI99_RS16095	COG4978	Transcriptional regulator
LI99_RS16095	COG0789	Transcriptional regulator
LI99_RS16105	COG5006	permease, DMT superfamily
LI99_RS16115	COG1177	transmembrane transport
LI99_RS16120	COG1176	ABC-type spermidine putrescine transport system, permease component I
LI99_RS16145	COG0473	3-isopropylmalate dehydrogenase activity
LI99_RS16155	COG0596	Alpha beta hydrolase
LI99_RS16195	COG1595	DNA-templated transcription, initiation
LI99_RS16200	COG2267	carboxylic ester hydrolase activity
LI99_RS16225	COG1028	Short-chain dehydrogenase reductase Sdr
LI99_RS16245	COG0604	alcohol dehydrogenase
LI99_RS16265	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
LI99_RS16285	COG1940	carbohydrate kinase activity
LI99_RS16350	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
LI99_RS16405	COG2267	carboxylic ester hydrolase activity
LI99_RS16415	COG1902	pentaerythritol trinitrate reductase activity
LI99_RS16430	COG3547	Transposase (IS116 IS110 IS902 family)
LI99_RS16460	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LI99_RS16495	COG1309	transcriptional regulator
LI99_RS16530	COG1309	transcriptional regulator
LI99_RS16540	COG1024	Enoyl-CoA hydratase
LI99_RS16555	COG4977	sequence-specific DNA binding
LI99_RS16565	COG1028	Short-chain dehydrogenase reductase Sdr
LI99_RS16575	COG2814	Major facilitator Superfamily
LI99_RS16585	COG1028	Short-chain dehydrogenase reductase Sdr
LI99_RS16590	COG0640	Transcriptional regulator
LI99_RS16635	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
LI99_RS16660	COG0477	Major facilitator Superfamily
LI99_RS16665	COG1012	belongs to the aldehyde dehydrogenase family
LI99_RS16680	COG1024	Enoyl-CoA hydratase
LI99_RS16690	COG1960	acyl-CoA dehydrogenase activity
LI99_RS16705	COG1028	Short-chain dehydrogenase reductase Sdr
LI99_RS16715	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LI99_RS16720	COG0477	Major facilitator Superfamily
LI99_RS16730	COG0154	amidase activity
LI99_RS16735	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
LI99_RS16740	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
LI99_RS16745	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LI99_RS16765	COG0596	Alpha beta hydrolase
LI99_RS16775	COG0604	alcohol dehydrogenase
LI99_RS16780	COG1309	transcriptional regulator
LI99_RS16830	COG1028	Short-chain dehydrogenase reductase Sdr
LI99_RS16835	COG0477	Major facilitator Superfamily
LI99_RS16850	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
LI99_RS16860	COG0300	oxidoreductase activity
LI99_RS16895	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
LI99_RS16900	COG0545	Peptidyl-prolyl cis-trans isomerase
LI99_RS16945	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
LI99_RS16960	COG2197	response regulator
LI99_RS16965	COG4585	Histidine kinase
LI99_RS16975	COG0546	phosphoglycolate phosphatase activity
LI99_RS16980	COG4221	oxidoreductase activity
LI99_RS16985	COG1309	transcriptional regulator
LI99_RS17010	COG1252	NADH dehydrogenase
LI99_RS17030	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
LI99_RS17055	COG0318	PFAM AMP-dependent synthetase and ligase
LI99_RS17105	COG0791	NLP P60 protein
LI99_RS17105	COG3883	PFAM NLP P60 protein
LI99_RS17110	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
LI99_RS17125	COG4948	Mandelate Racemase Muconate Lactonizing
LI99_RS17145	COG1595	DNA-templated transcription, initiation
LI99_RS17165	COG2755	lipolytic protein G-D-S-L family
LI99_RS17200	COG2409	Drug exporters of the RND superfamily
LI99_RS17200	COG1033	growth of symbiont in host cell
LI99_RS17205	COG0640	Transcriptional regulator
LI99_RS17220	COG3022	response to hydroperoxide
LI99_RS17250	COG3588	fructose-bisphosphate aldolase
LI99_RS17265	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LI99_RS17275	COG1546	Belongs to the CinA family
LI99_RS17275	COG1058	Belongs to the CinA family
LI99_RS17310	COG2070	2-Nitropropane dioxygenase
LI99_RS17320	COG0243	molybdopterin cofactor binding
LI99_RS17360	COG1376	ErfK ybiS ycfS ynhG family protein
LI99_RS17375	COG3104	oligopeptide transport
LI99_RS17380	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LI99_RS17390	COG0010	Belongs to the arginase family
LI99_RS17395	COG2271	Major facilitator Superfamily
LI99_RS17405	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LI99_RS17455	COG0765	amino acid transport
LI99_RS17460	COG0765	amino acid transport
LI99_RS17465	COG1126	abc transporter atp-binding protein
LI99_RS17480	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LI99_RS17490	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LI99_RS17495	COG1953	Uracil, thiamine, allantoin
LI99_RS17510	COG1028	Short-chain dehydrogenase reductase Sdr
LI99_RS17520	COG0174	glutamine synthetase
LI99_RS17535	COG2193	ferroxidase activity
LI99_RS17550	COG1024	Enoyl-CoA hydratase
LI99_RS17600	COG5002	protein histidine kinase activity
LI99_RS17605	COG0668	transmembrane transport
LI99_RS17615	COG4221	oxidoreductase activity
LI99_RS17640	COG0477	Major facilitator Superfamily
LI99_RS17645	COG1113	amino acid transport
LI99_RS17695	COG1879	ABC-type sugar transport system periplasmic component
LI99_RS17700	COG1879	ABC-type sugar transport system periplasmic component
LI99_RS17705	COG1172	Belongs to the binding-protein-dependent transport system permease family
LI99_RS17710	COG1129	ABC transporter
LI99_RS17715	COG1063	alcohol dehydrogenase
LI99_RS17720	COG1028	Short-chain dehydrogenase reductase Sdr
LI99_RS17725	COG1063	alcohol dehydrogenase
LI99_RS17735	COG1028	Short-chain dehydrogenase reductase Sdr
LI99_RS17750	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
LI99_RS17795	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LI99_RS17800	COG1252	NADH dehydrogenase
LI99_RS17805	COG0829	nickel cation binding
LI99_RS17810	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
LI99_RS17820	COG0804	urea catabolic process
LI99_RS17830	COG0831	urea catabolic process
LI99_RS17855	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
LI99_RS17865	COG3842	ATPase activity
LI99_RS17875	COG1840	ABC-type Fe3 transport system, periplasmic component
LI99_RS17880	COG1253	flavin adenine dinucleotide binding
LI99_RS17885	COG1253	flavin adenine dinucleotide binding
LI99_RS17930	COG1716	ATPase activity
LI99_RS17935	COG0509	glycine decarboxylation via glycine cleavage system
LI99_RS17960	COG0653	protein targeting
LI99_RS17975	COG1053	succinate dehydrogenase
LI99_RS18005	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LI99_RS18010	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LI99_RS18010	COG4651	solute:proton antiporter activity
LI99_RS18025	COG2272	Belongs to the type-B carboxylesterase lipase family
LI99_RS18205	COG2814	Major facilitator Superfamily
LI99_RS18220	COG0753	catalase activity
LI99_RS18225	COG3038	cytochrome b561
LI99_RS18285	COG0535	radical SAM domain protein
LI99_RS18295	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
LI99_RS18300	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
LI99_RS18320	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
LI99_RS18325	COG3284	Transcriptional regulator
LI99_RS18350	COG0730	response to heat
LI99_RS18365	COG1160	GTP binding
LI99_RS18380	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
LI99_RS18385	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
LI99_RS18400	COG0494	nUDIX hydrolase
LI99_RS18405	COG0504	CTP synthase activity
LI99_RS18440	COG0647	UMP catabolic process
LI99_RS18485	COG1131	(ABC) transporter
LI99_RS18500	COG2835	tetraacyldisaccharide 4'-kinase activity
LI99_RS18515	COG0488	(ABC) transporter
LI99_RS18520	COG0165	Argininosuccinate lyase
LI99_RS18525	COG0137	argininosuccinate synthase activity
LI99_RS18535	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
LI99_RS18540	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LI99_RS18545	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LI99_RS18550	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
LI99_RS18555	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
LI99_RS18560	COG0072	phenylalanine-tRNA ligase activity
LI99_RS18560	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LI99_RS18565	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
LI99_RS18585	COG1960	acyl-CoA dehydrogenase activity
LI99_RS18595	COG1414	Transcriptional regulator
LI99_RS18610	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
LI99_RS18615	COG0800	Aldolase
LI99_RS18620	COG2610	gluconate transmembrane transporter activity
LI99_RS18630	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
LI99_RS18635	COG0291	Belongs to the bacterial ribosomal protein bL35 family
LI99_RS18650	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LI99_RS18650	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
LI99_RS18700	COG1028	Short-chain dehydrogenase reductase Sdr
LI99_RS18765	COG2066	Belongs to the glutaminase family
LI99_RS18775	COG0531	amino acid
LI99_RS18780	COG2186	Transcriptional regulator
LI99_RS18785	COG1028	Short-chain dehydrogenase reductase Sdr
LI99_RS18790	COG1304	FMN binding
LI99_RS18795	COG1028	Short-chain dehydrogenase reductase Sdr
LI99_RS18805	COG0174	glutamine synthetase
LI99_RS18835	COG0539	negative regulation of cytoplasmic translation
LI99_RS18855	COG2339	peptidase activity
LI99_RS18895	COG1872	DUF167
LI99_RS18910	COG2272	Belongs to the type-B carboxylesterase lipase family
LI99_RS18920	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LI99_RS18925	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LI99_RS18935	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LI99_RS18945	COG0745	RESPONSE REGULATOR receiver
LI99_RS18960	COG0463	Glycosyl transferase, family 2
LI99_RS18965	COG0815	Transfers the fatty acyl group on membrane lipoproteins
LI99_RS18970	COG1228	amidohydrolase
LI99_RS19000	COG0714	Associated with various cellular activities
LI99_RS19060	COG0300	oxidoreductase activity
LI99_RS19100	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LI99_RS19115	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
LI99_RS19135	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
LI99_RS19140	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
LI99_RS19150	COG4122	O-methyltransferase activity
LI99_RS19155	COG5285	phytanoyl-CoA dioxygenase
LI99_RS19160	COG1917	Cupin 2, conserved barrel domain protein
LI99_RS19165	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
LI99_RS19175	COG1222	aaa ATPase
LI99_RS19190	COG1550	Protein conserved in bacteria
LI99_RS19225	COG1028	Short-chain dehydrogenase reductase Sdr
LI99_RS19275	COG2318	DinB family
LI99_RS19285	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LI99_RS19325	COG0574	Belongs to the PEP-utilizing enzyme family
LI99_RS19325	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LI99_RS19405	COG0589	response to stress
LI99_RS19420	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LI99_RS19440	COG1403	HNH endonuclease
LI99_RS19470	COG0028	Belongs to the TPP enzyme family
LI99_RS19485	COG2378	regulation of single-species biofilm formation
LI99_RS19495	COG0154	amidase activity
LI99_RS19525	COG1309	transcriptional regulator
LI99_RS19555	COG1960	acyl-CoA dehydrogenase activity
LI99_RS19560	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LI99_RS19565	COG3547	Transposase (IS116 IS110 IS902 family)
LI99_RS19570	COG0477	Major facilitator Superfamily
LI99_RS19575	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LI99_RS19580	COG1053	succinate dehydrogenase
LI99_RS19580	COG3976	FMN-binding domain protein
LI99_RS19595	COG0477	Major facilitator Superfamily
LI99_RS19615	COG1028	Short-chain dehydrogenase reductase Sdr
LI99_RS19620	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LI99_RS19625	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LI99_RS19640	COG1879	ABC-type sugar transport system periplasmic component
LI99_RS19645	COG1129	ABC transporter
LI99_RS19650	COG1172	Belongs to the binding-protein-dependent transport system permease family
LI99_RS19655	COG1063	alcohol dehydrogenase
LI99_RS19675	COG2508	Transcriptional regulator
LI99_RS19700	COG2233	PERMEase
LI99_RS19705	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LI99_RS19715	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LI99_RS19730	COG0318	PFAM AMP-dependent synthetase and ligase
LI99_RS19735	COG1024	Enoyl-CoA hydratase
LI99_RS19740	COG1309	transcriptional regulator
LI99_RS19745	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LI99_RS19755	COG0583	DNA-binding transcription factor activity
LI99_RS19790	COG1309	transcriptional regulator
LI99_RS19795	COG0702	epimerase
LI99_RS19805	COG0318	PFAM AMP-dependent synthetase and ligase
LI99_RS19815	COG1012	belongs to the aldehyde dehydrogenase family
LI99_RS19825	COG0778	Nitroreductase
LI99_RS19830	COG3485	protocatechuate 3,4-dioxygenase
LI99_RS19855	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LI99_RS19860	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LI99_RS19870	COG0477	Major facilitator Superfamily
LI99_RS19885	COG1028	Short-chain dehydrogenase reductase Sdr
LI99_RS19895	COG2186	Transcriptional regulator
LI99_RS19900	COG0477	Major facilitator Superfamily
LI99_RS19910	COG0436	Aminotransferase
LI99_RS19920	COG0154	amidase activity
LI99_RS19935	COG0318	PFAM AMP-dependent synthetase and ligase
LI99_RS19965	COG1309	transcriptional regulator
LI99_RS19970	COG1028	Short-chain dehydrogenase reductase Sdr
LI99_RS19975	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LI99_RS19975	COG1042	CoA-binding domain protein
LI99_RS19975	COG0045	succinate-CoA ligase (ADP-forming) activity
LI99_RS19985	COG1024	Enoyl-CoA hydratase
LI99_RS19990	COG2271	Major facilitator Superfamily
LI99_RS19995	COG2267	carboxylic ester hydrolase activity
LI99_RS20005	COG3547	Transposase (IS116 IS110 IS902 family)
LI99_RS20035	COG0477	Major facilitator Superfamily
LI99_RS20060	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LI99_RS20065	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LI99_RS20070	COG0667	Aldo Keto reductase
LI99_RS20095	COG4172	Belongs to the ABC transporter superfamily
LI99_RS20100	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LI99_RS20110	COG0747	negative chemotaxis
LI99_RS20120	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LI99_RS20145	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
LI99_RS20150	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
LI99_RS20155	COG1250	3-hydroxyacyl-CoA dehydrogenase
LI99_RS20160	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LI99_RS20165	COG0318	PFAM AMP-dependent synthetase and ligase
LI99_RS20170	COG1960	acyl-CoA dehydrogenase activity
LI99_RS20175	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
LI99_RS20180	COG1250	3-hydroxyacyl-CoA dehydrogenase
LI99_RS20185	COG1250	3-hydroxyacyl-CoA dehydrogenase
LI99_RS20190	COG1028	Short-chain dehydrogenase reductase Sdr
LI99_RS20195	COG1960	acyl-CoA dehydrogenase activity
LI99_RS20200	COG1024	Enoyl-CoA hydratase
LI99_RS20205	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LI99_RS20210	COG2186	Transcriptional regulator
LI99_RS20215	COG0477	Major facilitator Superfamily
LI99_RS20235	COG1335	isochorismatase
LI99_RS20245	COG2264	protein methyltransferase activity
LI99_RS20280	COG1090	epimerase
LI99_RS20300	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LI99_RS20335	COG2223	nitrite transmembrane transporter activity
LI99_RS20345	COG4569	acetaldehyde dehydrogenase (acetylating) activity
LI99_RS20350	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LI99_RS20370	COG3328	transposase activity
LI99_RS20410	COG1024	Enoyl-CoA hydratase
LI99_RS20430	COG4670	ketone body catabolic process
LI99_RS20435	COG1028	Short-chain dehydrogenase reductase Sdr
LI99_RS20440	COG1129	ABC transporter
LI99_RS20445	COG1172	Belongs to the binding-protein-dependent transport system permease family
LI99_RS20460	COG1414	Transcriptional regulator
LI99_RS20465	COG0640	Transcriptional regulator
LI99_RS20475	COG0655	NAD(P)H dehydrogenase (quinone) activity
LI99_RS20480	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LI99_RS20495	COG0140	phosphoribosyl-ATP diphosphatase activity
LI99_RS20500	COG0477	Major facilitator Superfamily
LI99_RS20515	COG1410	methionine synthase
LI99_RS20515	COG0646	methionine synthase
LI99_RS20530	COG1028	Short-chain dehydrogenase reductase Sdr
LI99_RS20535	COG0215	cysteine-tRNA ligase activity
LI99_RS20560	COG1968	undecaprenyl-diphosphatase activity
LI99_RS20580	COG0167	dihydroorotate dehydrogenase activity
LI99_RS20590	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LI99_RS20605	COG1404	Belongs to the peptidase S8 family
LI99_RS20620	COG0243	molybdopterin cofactor binding
LI99_RS20625	COG0589	response to stress
LI99_RS20645	COG3290	protein histidine kinase activity
LI99_RS20655	COG2124	cytochrome p450
LI99_RS20660	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LI99_RS20660	COG0519	Catalyzes the synthesis of GMP from XMP
LI99_RS20675	COG3599	regulation of cell shape
LI99_RS20685	COG1799	cell septum assembly
LI99_RS20710	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
LI99_RS20715	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LI99_RS20720	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LI99_RS20730	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
LI99_RS20735	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LI99_RS20750	COG0768	penicillin binding
LI99_RS20760	COG0275	rRNA processing
LI99_RS20765	COG2001	Belongs to the MraZ family
LI99_RS20785	COG0142	geranyltranstransferase activity
LI99_RS20805	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
LI99_RS20820	COG5650	phosphatidylinositol metabolic process
LI99_RS20835	COG0003	Pfam Anion-transporting ATPase
LI99_RS20850	COG1022	Amp-dependent synthetase and ligase
LI99_RS20855	COG0438	transferase activity, transferring glycosyl groups
LI99_RS20875	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LI99_RS20880	COG1845	cytochrome c oxidase, subunit III
LI99_RS20925	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LI99_RS20955	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
LI99_RS20960	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LI99_RS20995	COG1090	epimerase
LI99_RS21000	COG0321	lipoyl(octanoyl) transferase activity
LI99_RS21005	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
LI99_RS21025	COG0174	glutamine synthetase
LI99_RS21030	COG1490	D-aminoacyl-tRNA deacylase activity
LI99_RS21035	COG2259	Doxx family
LI99_RS21040	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
LI99_RS21045	COG0174	glutamine synthetase
LI99_RS21070	COG1024	Enoyl-CoA hydratase
LI99_RS21080	COG0318	PFAM AMP-dependent synthetase and ligase
LI99_RS21090	COG3634	alkyl hydroperoxide reductase activity
LI99_RS21095	COG1396	sequence-specific DNA binding
LI99_RS21130	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
LI99_RS21150	COG2169	Transcriptional regulator
LI99_RS21150	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LI99_RS21185	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
LI99_RS21195	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
LI99_RS21200	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LI99_RS21205	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LI99_RS21220	COG1028	Short-chain dehydrogenase reductase Sdr
LI99_RS21305	COG0028	Belongs to the TPP enzyme family
LI99_RS21320	COG1028	Short-chain dehydrogenase reductase Sdr
LI99_RS21335	COG0747	negative chemotaxis
LI99_RS21340	COG0601	transmembrane transport
LI99_RS21345	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LI99_RS21350	COG4172	Belongs to the ABC transporter superfamily
LI99_RS21355	COG1028	Short-chain dehydrogenase reductase Sdr
LI99_RS21430	COG1028	Short-chain dehydrogenase reductase Sdr
LI99_RS21435	COG0531	amino acid
LI99_RS21440	COG2197	response regulator
LI99_RS21470	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LI99_RS21485	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LI99_RS21500	COG1960	acyl-CoA dehydrogenase activity
LI99_RS21515	COG0583	DNA-binding transcription factor activity
LI99_RS21535	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LI99_RS21550	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LI99_RS21570	COG1595	DNA-templated transcription, initiation
LI99_RS21595	COG0633	Ferredoxin
LI99_RS21595	COG0543	2 iron, 2 sulfur cluster binding
LI99_RS21600	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
LI99_RS21610	COG2323	membrane
LI99_RS21630	COG1028	Short-chain dehydrogenase reductase Sdr
LI99_RS21665	COG0477	Major facilitator Superfamily
LI99_RS21685	COG2909	trisaccharide binding
LI99_RS21710	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
LI99_RS21730	COG1028	Short-chain dehydrogenase reductase Sdr
LI99_RS21760	COG2337	Toxic component of a toxin-antitoxin (TA) module
LI99_RS21775	COG2072	flavoprotein involved in K transport
LI99_RS21820	COG0028	Belongs to the TPP enzyme family
LI99_RS21825	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LI99_RS21830	COG5522	Integral membrane protein (intg_mem_TP0381)
LI99_RS21850	COG1175	transmembrane transport
LI99_RS21860	COG1653	transport
LI99_RS21880	COG2814	Major facilitator Superfamily
LI99_RS21925	COG0358	DNA primase activity
LI99_RS21930	COG0232	Belongs to the dGTPase family. Type 2 subfamily
LI99_RS21940	COG0423	glycine-tRNA ligase activity
LI99_RS21965	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LI99_RS21970	COG1381	Involved in DNA repair and RecF pathway recombination
LI99_RS21995	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
LI99_RS22015	COG1301	dicarboxylic acid transport
LI99_RS22030	COG0484	heat shock protein binding
LI99_RS22035	COG1420	regulation of RNA biosynthetic process
LI99_RS22065	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LI99_RS22090	COG1021	2,3-dihydroxybenzoate-AMP ligase
LI99_RS22110	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
LI99_RS22115	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LI99_RS22120	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LI99_RS22130	COG1169	isochorismate synthase
LI99_RS22160	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
LI99_RS22165	COG4208	sulfate ABC transporter
LI99_RS22170	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
LI99_RS22175	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
LI99_RS22185	COG3387	PFAM Glycoside hydrolase 15-related
LI99_RS22195	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LI99_RS22200	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LI99_RS22205	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LI99_RS22210	COG4552	Acetyltransferase involved in intracellular survival and related
LI99_RS22220	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LI99_RS22225	COG0601	transmembrane transport
LI99_RS22230	COG4166	transmembrane transport
LI99_RS22235	COG2813	Specifically methylates the guanine in position
LI99_RS22260	COG3547	Transposase (IS116 IS110 IS902 family)
LI99_RS22270	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LI99_RS22290	COG0481	GTPase activity
LI99_RS22300	COG1120	ATPase activity
LI99_RS22305	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LI99_RS22325	COG0517	IMP dehydrogenase activity
LI99_RS22325	COG0516	GMP reductase activity
LI99_RS22330	COG0667	Aldo Keto reductase
LI99_RS22340	COG1234	tRNA 3'-trailer cleavage
LI99_RS22345	COG1305	Transglutaminase-like
LI99_RS22360	COG0268	Binds directly to 16S ribosomal RNA
LI99_RS22375	COG1596	polysaccharide export
LI99_RS22375	COG1555	photosystem II stabilization
LI99_RS22385	COG0330	HflC and HflK could
LI99_RS22395	COG2755	lipolytic protein G-D-S-L family
LI99_RS22400	COG0406	alpha-ribazole phosphatase activity
LI99_RS22405	COG0799	negative regulation of ribosome biogenesis
LI99_RS22410	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
LI99_RS22420	COG0542	response to heat
LI99_RS22425	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
LI99_RS22430	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
LI99_RS22430	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
LI99_RS22440	COG1116	anion transmembrane transporter activity
LI99_RS22445	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LI99_RS22455	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LI99_RS22525	COG0583	DNA-binding transcription factor activity
LI99_RS22590	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
LI99_RS22595	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
LI99_RS22600	COG0211	Belongs to the bacterial ribosomal protein bL27 family
LI99_RS22605	COG0261	This protein binds to 23S rRNA in the presence of protein L20
LI99_RS22610	COG1530	ribonuclease E activity
LI99_RS22615	COG0105	UTP biosynthetic process
LI99_RS22625	COG0285	dihydrofolate synthase activity
LI99_RS22640	COG3268	Saccharopine dehydrogenase
LI99_RS22645	COG1506	peptidase
LI99_RS22645	COG4946	Tricorn protease homolog
LI99_RS22645	COG0823	Involved in the tonB-independent uptake of proteins
LI99_RS22655	COG0004	ammonium transporteR
LI99_RS22670	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LI99_RS22690	COG1388	LysM domain
LI99_RS22695	COG0746	molybdenum cofactor guanylyltransferase activity
LI99_RS22700	COG1013	pyruvate-flavodoxin oxidoreductase activity
LI99_RS22705	COG0674	pyruvate-flavodoxin oxidoreductase activity
LI99_RS22705	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
LI99_RS22725	COG0673	inositol 2-dehydrogenase activity
LI99_RS22730	COG1082	Xylose isomerase domain protein TIM barrel
LI99_RS22735	COG0673	inositol 2-dehydrogenase activity
LI99_RS22745	COG0667	Aldo Keto reductase
LI99_RS22750	COG2207	Transcriptional regulator
LI99_RS22760	COG1172	Belongs to the binding-protein-dependent transport system permease family
LI99_RS22770	COG2188	Transcriptional regulator
LI99_RS22775	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LI99_RS22785	COG3718	enzyme involved in inositol metabolism
LI99_RS22790	COG3962	Belongs to the TPP enzyme family
LI99_RS22800	COG0673	inositol 2-dehydrogenase activity
LI99_RS22815	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
LI99_RS22825	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
LI99_RS22840	COG0544	peptidyl-prolyl cis-trans isomerase activity
LI99_RS22890	COG0667	Aldo Keto reductase
LI99_RS22905	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
LI99_RS22925	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
LI99_RS22945	COG0366	Alpha amylase catalytic
LI99_RS22960	COG2902	Dehydrogenase
LI99_RS22980	COG2937	Belongs to the GPAT DAPAT family
LI99_RS23000	COG2267	carboxylic ester hydrolase activity
LI99_RS23015	COG0508	dehydrogenase complex catalyzes the overall conversion of
LI99_RS23040	COG1960	acyl-CoA dehydrogenase activity
LI99_RS23050	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LI99_RS23075	COG0300	oxidoreductase activity
LI99_RS23080	COG0433	COG0433 Predicted ATPase
LI99_RS23100	COG3321	synthase
LI99_RS23100	COG1028	Short-chain dehydrogenase reductase Sdr
LI99_RS23100	COG0604	alcohol dehydrogenase
LI99_RS23160	COG3510	cephalosporin hydroxylase
LI99_RS23190	COG1376	ErfK ybiS ycfS ynhG family protein
LI99_RS23245	COG0736	holo-[acyl-carrier-protein] synthase activity
LI99_RS23265	COG3842	ATPase activity
LI99_RS23270	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
LI99_RS23275	COG1176	ABC-type spermidine putrescine transport system, permease component I
LI99_RS23280	COG1177	transmembrane transport
LI99_RS23330	COG0318	PFAM AMP-dependent synthetase and ligase
LI99_RS23335	COG1024	Enoyl-CoA hydratase
LI99_RS23350	COG0183	Belongs to the thiolase family
LI99_RS23390	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
LI99_RS23430	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LI99_RS23435	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LI99_RS23445	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LI99_RS23480	COG1960	acyl-CoA dehydrogenase activity
LI99_RS23485	COG1960	acyl-CoA dehydrogenase activity
LI99_RS23515	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
LI99_RS23535	COG2084	Dehydrogenase
LI99_RS23545	COG2124	cytochrome p450
LI99_RS23565	COG1141	Ferredoxin
LI99_RS23580	COG1309	transcriptional regulator
LI99_RS23585	COG1960	acyl-CoA dehydrogenase activity
LI99_RS23595	COG1063	alcohol dehydrogenase
LI99_RS23610	COG1309	transcriptional regulator
LI99_RS23615	COG1960	acyl-CoA dehydrogenase activity
LI99_RS23620	COG0183	Belongs to the thiolase family
LI99_RS23625	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LI99_RS23630	COG1028	Short-chain dehydrogenase reductase Sdr
LI99_RS23655	COG4638	Rieske (2fe-2S)
LI99_RS23665	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
LI99_RS23675	COG1960	acyl-CoA dehydrogenase activity
LI99_RS23685	COG1024	Enoyl-CoA hydratase
LI99_RS23695	COG1028	Short-chain dehydrogenase reductase Sdr
LI99_RS23700	COG1028	Short-chain dehydrogenase reductase Sdr
LI99_RS23705	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LI99_RS23710	COG1024	Enoyl-CoA hydratase
LI99_RS23715	COG0006	proline dipeptidase activity
LI99_RS23720	COG0024	Methionine aminopeptidase
LI99_RS23760	COG1028	Short-chain dehydrogenase reductase Sdr
LI99_RS23770	COG1053	succinate dehydrogenase
LI99_RS23775	COG3384	dioxygenase
LI99_RS23780	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LI99_RS23785	COG2267	carboxylic ester hydrolase activity
LI99_RS23795	COG1053	succinate dehydrogenase
LI99_RS23820	COG1960	acyl-CoA dehydrogenase activity
LI99_RS23825	COG1960	acyl-CoA dehydrogenase activity
LI99_RS23830	COG0318	PFAM AMP-dependent synthetase and ligase
LI99_RS23835	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LI99_RS23840	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LI99_RS23845	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LI99_RS23850	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LI99_RS23855	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LI99_RS23855	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LI99_RS23860	COG1028	Short-chain dehydrogenase reductase Sdr
LI99_RS23865	COG0318	PFAM AMP-dependent synthetase and ligase
LI99_RS23875	COG0477	Major facilitator Superfamily
LI99_RS23895	COG0477	Major facilitator Superfamily
LI99_RS23900	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LI99_RS23905	COG0450	alkyl hydroperoxide reductase
LI99_RS23950	COG2123	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
LI99_RS23955	COG1234	tRNA 3'-trailer cleavage
LI99_RS23960	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
LI99_RS24000	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
LI99_RS24015	COG4257	antibiotic catabolic process
LI99_RS24020	COG0058	SHG alpha-glucan phosphorylase activity
LI99_RS24025	COG0366	Alpha amylase catalytic
LI99_RS24030	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
LI99_RS24040	COG2409	Drug exporters of the RND superfamily
LI99_RS24045	COG0183	Belongs to the thiolase family
LI99_RS24050	COG0346	lactoylglutathione lyase activity
LI99_RS24060	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
LI99_RS24085	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LI99_RS24105	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LI99_RS24120	COG0355	proton-transporting ATP synthase activity, rotational mechanism
LI99_RS24125	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
LI99_RS24130	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
LI99_RS24135	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
LI99_RS24140	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
LI99_RS24140	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LI99_RS24145	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
LI99_RS24150	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LI99_RS24155	COG0356	it plays a direct role in the translocation of protons across the membrane
LI99_RS24175	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LI99_RS24185	COG2890	protein-(glutamine-N5) methyltransferase activity
LI99_RS24190	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
LI99_RS24195	COG0254	rRNA binding
LI99_RS24200	COG0318	PFAM AMP-dependent synthetase and ligase
LI99_RS24205	COG1309	transcriptional regulator
LI99_RS24215	COG0083	homoserine kinase activity
LI99_RS24220	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
LI99_RS24225	COG0460	homoserine dehydrogenase
LI99_RS24230	COG0019	diaminopimelate decarboxylase activity
LI99_RS24235	COG0018	arginyl-trna synthetase
LI99_RS24285	COG4585	Histidine kinase
LI99_RS24290	COG2197	response regulator
LI99_RS24345	COG2814	Major facilitator Superfamily
LI99_RS24375	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
LI99_RS24385	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
LI99_RS24390	COG2205	protein histidine kinase activity
LI99_RS24395	COG0745	RESPONSE REGULATOR receiver
LI99_RS24545	COG1063	alcohol dehydrogenase
LI99_RS24590	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LI99_RS24605	COG1733	regulation of RNA biosynthetic process
LI99_RS24620	COG0277	FAD linked oxidase domain protein
LI99_RS24665	COG0277	FAD linked oxidase domain protein
LI99_RS24675	COG2814	Major facilitator Superfamily
LI99_RS24685	COG0567	Dehydrogenase, E1 component
LI99_RS24685	COG0508	dehydrogenase complex catalyzes the overall conversion of
LI99_RS24720	COG0598	Magnesium transport protein CorA
LI99_RS24760	COG2301	Belongs to the HpcH HpaI aldolase family
LI99_RS24765	COG2239	Acts as a magnesium transporter
LI99_RS24785	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LI99_RS24790	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LI99_RS24795	COG5662	AntiSigma factor
LI99_RS24800	COG1595	DNA-templated transcription, initiation
LI99_RS24805	COG4122	O-methyltransferase activity
LI99_RS24810	COG1309	transcriptional regulator
LI99_RS24815	COG1131	(ABC) transporter
LI99_RS24820	COG3559	Exporter of polyketide antibiotics
LI99_RS24835	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
LI99_RS24840	COG0297	glycogen (starch) synthase activity
LI99_RS24850	COG0519	Catalyzes the synthesis of GMP from XMP
LI99_RS24860	COG0463	Glycosyl transferase, family 2
LI99_RS24870	COG0318	PFAM AMP-dependent synthetase and ligase
LI99_RS24875	COG1611	Belongs to the LOG family
LI99_RS24940	COG0488	(ABC) transporter
LI99_RS24945	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LI99_RS24950	COG2171	N-acyltransferase activity
LI99_RS24975	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
LI99_RS25000	COG0318	PFAM AMP-dependent synthetase and ligase
LI99_RS25015	COG0506	proline dehydrogenase activity
LI99_RS25020	COG1012	belongs to the aldehyde dehydrogenase family
LI99_RS25035	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
LI99_RS25055	COG0446	pyridine nucleotide-disulphide oxidoreductase
LI99_RS25055	COG1902	pentaerythritol trinitrate reductase activity
LI99_RS25060	COG2353	YceI-like domain
LI99_RS25080	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
LI99_RS25085	COG0747	negative chemotaxis
LI99_RS25095	COG1217	gtp-binding protein TYPA
LI99_RS25130	COG1140	nitrate reductase beta subunit
LI99_RS25155	COG1472	Belongs to the glycosyl hydrolase 3 family
LI99_RS25165	COG1175	transmembrane transport
LI99_RS25180	COG2154	pterin-4-alpha-carbinolamine dehydratase
LI99_RS25185	COG1051	belongs to the nudix hydrolase family
LI99_RS25205	COG0778	Nitroreductase
LI99_RS25220	COG3275	phosphorelay sensor kinase activity
LI99_RS25225	COG3279	Response regulator of the LytR AlgR family
LI99_RS25235	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LI99_RS25240	COG1733	regulation of RNA biosynthetic process
LI99_RS25250	COG0604	alcohol dehydrogenase
LI99_RS25260	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LI99_RS25280	COG3467	pyridoxamine 5'-phosphate
LI99_RS25305	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
LI99_RS25320	COG2409	Drug exporters of the RND superfamily
LI99_RS25350	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LI99_RS25355	COG1024	Enoyl-CoA hydratase
LI99_RS25375	COG0702	epimerase
LI99_RS25385	COG0667	Aldo Keto reductase
LI99_RS25395	COG4977	sequence-specific DNA binding
LI99_RS25415	COG1960	acyl-CoA dehydrogenase activity
LI99_RS25420	COG1024	Enoyl-CoA hydratase
LI99_RS25425	COG0183	Belongs to the thiolase family
LI99_RS25430	COG2186	Transcriptional regulator
LI99_RS25450	COG1028	Short-chain dehydrogenase reductase Sdr
LI99_RS25480	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
LI99_RS25530	COG0657	acetylesterase activity
LI99_RS25540	COG0012	GTP binding
LI99_RS25600	COG1028	Short-chain dehydrogenase reductase Sdr
LI99_RS25670	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LI99_RS25680	COG0572	uridine kinase
LI99_RS25705	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LI99_RS25715	COG3631	Ketosteroid isomerase-related protein
LI99_RS25720	COG1331	Highly conserved protein containing a thioredoxin domain
LI99_RS25730	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
LI99_RS25740	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LI99_RS25755	COG1960	acyl-CoA dehydrogenase activity
LI99_RS25765	COG5473	translation initiation factor activity
LI99_RS25775	COG0657	acetylesterase activity
LI99_RS25780	COG2755	lipolytic protein G-D-S-L family
LI99_RS25785	COG0183	Belongs to the thiolase family
LI99_RS25790	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
LI99_RS25800	COG1024	Enoyl-CoA hydratase
LI99_RS25850	COG1063	alcohol dehydrogenase
LI99_RS25855	COG3804	dihydrodipicolinate reductase
LI99_RS25870	COG0318	PFAM AMP-dependent synthetase and ligase
LI99_RS25885	COG0318	PFAM AMP-dependent synthetase and ligase
LI99_RS25895	COG0028	Belongs to the TPP enzyme family
LI99_RS25910	COG1028	Short-chain dehydrogenase reductase Sdr
LI99_RS25920	COG1301	dicarboxylic acid transport
LI99_RS25925	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LI99_RS25930	COG3290	protein histidine kinase activity
LI99_RS25935	COG4565	transcriptional regulatory protein
LI99_RS25945	COG1309	transcriptional regulator
LI99_RS25960	COG2226	methyltransferase
LI99_RS25995	COG1126	abc transporter atp-binding protein
LI99_RS26000	COG0765	amino acid transport
LI99_RS26005	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LI99_RS26045	COG2119	membrane
LI99_RS26140	COG0318	PFAM AMP-dependent synthetase and ligase
LI99_RS26165	COG2226	methyltransferase
LI99_RS26195	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
LI99_RS26240	COG0765	amino acid transport
LI99_RS26245	COG0765	amino acid transport
LI99_RS26250	COG1126	abc transporter atp-binding protein
LI99_RS26260	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LI99_RS26270	COG2186	Transcriptional regulator
LI99_RS26310	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LI99_RS26315	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LI99_RS26325	COG1937	Protein conserved in bacteria
LI99_RS26345	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
LI99_RS26355	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
LI99_RS26370	COG0514	ATP-dependent DNA helicase (RecQ)
LI99_RS26380	COG0514	ATP-dependent DNA helicase (RecQ)
LI99_RS26395	COG4221	oxidoreductase activity
LI99_RS26405	COG2217	Heavy metal translocating P-type atpase
LI99_RS26410	COG0640	Transcriptional regulator
LI99_RS26425	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
LI99_RS26465	COG0148	phosphopyruvate hydratase activity
LI99_RS26475	COG0672	)-iron permease
LI99_RS26480	COG2822	iron ion transport
LI99_RS26485	COG2837	iron assimilation
LI99_RS26495	COG3956	TIGRFAM MazG family protein
LI99_RS26505	COG1309	transcriptional regulator
LI99_RS26515	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
LI99_RS26540	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
LI99_RS26545	COG0193	aminoacyl-tRNA hydrolase activity
LI99_RS26560	COG0318	PFAM AMP-dependent synthetase and ligase
LI99_RS26565	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
LI99_RS26570	COG0515	serine threonine protein kinase
LI99_RS26570	COG2815	serine threonine protein kinase
LI99_RS26580	COG3583	domain protein
LI99_RS26585	COG0084	hydrolase, TatD family'
LI99_RS26595	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
LI99_RS26600	COG0446	pyridine nucleotide-disulphide oxidoreductase
LI99_RS26610	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LI99_RS26630	COG2235	arginine
LI99_RS26660	COG5651	PPE family
LI99_RS26660	COG3391	amine dehydrogenase activity
LI99_RS26670	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LI99_RS26675	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LI99_RS26675	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LI99_RS26700	COG2084	Dehydrogenase
LI99_RS26710	COG1028	Short-chain dehydrogenase reductase Sdr
LI99_RS26740	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LI99_RS26745	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LI99_RS26750	COG1113	amino acid transport
LI99_RS26760	COG1414	Transcriptional regulator
LI99_RS26765	COG3960	tartronate-semialdehyde synthase activity
LI99_RS26770	COG2084	Dehydrogenase
LI99_RS26775	COG3622	Belongs to the hyi family
LI99_RS26795	COG1970	mechanosensitive ion channel activity
LI99_RS26810	COG0521	Mo-molybdopterin cofactor biosynthetic process
LI99_RS26810	COG0315	cyclic pyranopterin monophosphate synthase activity
LI99_RS26815	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LI99_RS26820	COG2205	protein histidine kinase activity
LI99_RS26825	COG0745	RESPONSE REGULATOR receiver
LI99_RS26840	COG1960	acyl-CoA dehydrogenase activity
LI99_RS26845	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LI99_RS26905	COG0702	epimerase
LI99_RS26950	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
LI99_RS27015	COG0045	succinate-CoA ligase (ADP-forming) activity
LI99_RS27020	COG0739	heme binding
LI99_RS27040	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LI99_RS27070	COG1605	Chorismate mutase
LI99_RS27075	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
LI99_RS27075	COG2755	lipolytic protein G-D-S-L family
LI99_RS27090	COG0166	Belongs to the GPI family
LI99_RS27115	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LI99_RS27120	COG1289	transmembrane transporter activity
LI99_RS27125	COG1950	PFAM Membrane protein of
LI99_RS27175	COG2814	Major facilitator Superfamily
LI99_RS27190	COG2814	Major facilitator Superfamily
LI99_RS27200	COG0328	RNA-DNA hybrid ribonuclease activity
LI99_RS27210	COG4977	sequence-specific DNA binding
LI99_RS27215	COG2249	NAD(P)H dehydrogenase (quinone) activity
LI99_RS27225	COG1846	Transcriptional regulator
LI99_RS27235	COG4221	oxidoreductase activity
LI99_RS27240	COG4221	oxidoreductase activity
LI99_RS27245	COG1793	dna ligase
LI99_RS27245	COG3285	dna ligase
LI99_RS27250	COG3842	ATPase activity
LI99_RS27255	COG0395	ABC-type sugar transport system, permease component
LI99_RS27260	COG1175	transmembrane transport
LI99_RS27275	COG0246	Mannitol dehydrogenase
LI99_RS27295	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
LI99_RS27300	COG5522	Integral membrane protein (intg_mem_TP0381)
LI99_RS27310	COG1403	HNH endonuclease
LI99_RS27345	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
LI99_RS27355	COG0028	Belongs to the TPP enzyme family
LI99_RS27360	COG0069	glutamate synthase activity
LI99_RS27365	COG1846	Transcriptional regulator
LI99_RS27370	COG1028	Short-chain dehydrogenase reductase Sdr
LI99_RS27415	COG1271	oxidase subunit
LI99_RS27440	COG1733	regulation of RNA biosynthetic process
LI99_RS27480	COG1960	acyl-CoA dehydrogenase activity
LI99_RS27485	COG1960	acyl-CoA dehydrogenase activity
LI99_RS27490	COG1024	Enoyl-CoA hydratase
LI99_RS27500	COG1960	acyl-CoA dehydrogenase activity
LI99_RS27505	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LI99_RS27510	COG1028	Short-chain dehydrogenase reductase Sdr
LI99_RS27515	COG2072	flavoprotein involved in K transport
LI99_RS27530	COG1028	Short-chain dehydrogenase reductase Sdr
LI99_RS27535	COG3386	PFAM SMP-30 Gluconolaconase
LI99_RS27540	COG2188	Transcriptional regulator
LI99_RS27545	COG0318	PFAM AMP-dependent synthetase and ligase
LI99_RS27555	COG0318	PFAM AMP-dependent synthetase and ligase
LI99_RS27570	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LI99_RS27610	COG1511	domain protein
LI99_RS27615	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
LI99_RS27635	COG0318	PFAM AMP-dependent synthetase and ligase
LI99_RS27640	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LI99_RS27655	COG0583	DNA-binding transcription factor activity
LI99_RS27660	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
LI99_RS27665	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LI99_RS27670	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
LI99_RS27675	COG0583	DNA-binding transcription factor activity
LI99_RS27680	COG0596	Alpha beta hydrolase
LI99_RS27685	COG1132	(ABC) transporter
LI99_RS27695	COG1132	(ABC) transporter
LI99_RS27710	COG0545	Peptidyl-prolyl cis-trans isomerase
LI99_RS27750	COG1309	transcriptional regulator
LI99_RS27760	COG0259	pyridoxamine-phosphate oxidase activity
LI99_RS27775	COG0346	lactoylglutathione lyase activity
LI99_RS27780	COG0640	Transcriptional regulator
LI99_RS27805	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
LI99_RS27845	COG2814	Major facilitator Superfamily
LI99_RS27855	COG0435	Glutathione S-transferase
LI99_RS27860	COG1278	Cold shock
LI99_RS27865	COG3304	Inner membrane component domain
LI99_RS27870	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
LI99_RS27890	COG0521	Mo-molybdopterin cofactor biosynthetic process
LI99_RS27890	COG0315	cyclic pyranopterin monophosphate synthase activity
LI99_RS27940	COG1028	Short-chain dehydrogenase reductase Sdr
LI99_RS27945	COG0477	Major facilitator Superfamily
LI99_RS27955	COG1028	Short-chain dehydrogenase reductase Sdr
LI99_RS27985	COG1024	Enoyl-CoA hydratase
LI99_RS27985	COG1250	3-hydroxyacyl-CoA dehydrogenase
LI99_RS27990	COG0183	Belongs to the thiolase family
LI99_RS28020	COG4266	Belongs to the allantoicase family
LI99_RS28035	COG1953	Uracil, thiamine, allantoin
LI99_RS28055	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LI99_RS28060	COG3961	Belongs to the TPP enzyme family
LI99_RS28155	COG0582	viral genome integration into host DNA
LI99_RS28180	COG5651	PPE family
LI99_RS28180	COG3391	amine dehydrogenase activity
LI99_RS28185	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LI99_RS28210	COG2346	COG2346, Truncated hemoglobins
LI99_RS28275	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LI99_RS28295	COG0456	acetyltransferase
LI99_RS28300	COG0745	RESPONSE REGULATOR receiver
LI99_RS28325	COG2897	thiosulfate sulfurtransferase activity
LI99_RS28340	COG4044	May play a role in the intracellular transport of hydrophobic ligands
LI99_RS28360	COG0354	folic acid binding
LI99_RS28375	COG0702	epimerase
LI99_RS28385	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LI99_RS28390	COG1028	Short-chain dehydrogenase reductase Sdr
LI99_RS28410	COG2011	ABC-type metal ion transport system permease component
LI99_RS28415	COG1464	Belongs to the NlpA lipoprotein family
LI99_RS28435	COG1028	Short-chain dehydrogenase reductase Sdr
LI99_RS28445	COG1012	belongs to the aldehyde dehydrogenase family
LI99_RS28490	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LI99_RS28500	COG0028	Belongs to the TPP enzyme family
LI99_RS28510	COG1362	aminopeptidase activity
LI99_RS28515	COG2837	iron assimilation
LI99_RS28530	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LI99_RS28545	COG3573	Dehydrogenase
LI99_RS28555	COG0386	Belongs to the glutathione peroxidase family
LI99_RS28575	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
LI99_RS28605	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LI99_RS28615	COG0531	amino acid
LI99_RS28635	COG2124	cytochrome p450
LI99_RS28680	COG0300	oxidoreductase activity
LI99_RS28685	COG2124	cytochrome p450
LI99_RS28725	COG2205	protein histidine kinase activity
LI99_RS28730	COG0745	RESPONSE REGULATOR receiver
LI99_RS28790	COG2084	Dehydrogenase
LI99_RS28800	COG1024	Enoyl-CoA hydratase
LI99_RS28825	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
LI99_RS28850	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
LI99_RS28875	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LI99_RS28880	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LI99_RS28885	COG1028	Short-chain dehydrogenase reductase Sdr
LI99_RS28895	COG1960	acyl-CoA dehydrogenase activity
LI99_RS28900	COG1960	acyl-CoA dehydrogenase activity
LI99_RS28905	COG0318	PFAM AMP-dependent synthetase and ligase
LI99_RS28925	COG1012	belongs to the aldehyde dehydrogenase family
LI99_RS28930	COG2070	2-Nitropropane dioxygenase
LI99_RS28940	COG1024	Enoyl-CoA hydratase
LI99_RS28955	COG2124	cytochrome p450
LI99_RS28965	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LI99_RS28980	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
LI99_RS28990	COG4638	Rieske (2fe-2S)
LI99_RS29020	COG1028	Short-chain dehydrogenase reductase Sdr
LI99_RS29040	COG0514	ATP-dependent DNA helicase (RecQ)
LI99_RS29050	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LI99_RS29055	COG4569	acetaldehyde dehydrogenase (acetylating) activity
LI99_RS29060	COG3971	2-oxopent-4-enoate hydratase activity
LI99_RS29065	COG1053	succinate dehydrogenase
LI99_RS29070	COG2030	dehydratase
LI99_RS29075	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LI99_RS29110	COG0110	maltose O-acetyltransferase activity
LI99_RS29115	COG0438	transferase activity, transferring glycosyl groups
LI99_RS29140	COG1088	dTDP-glucose 4,6-dehydratase activity
LI99_RS29180	COG0297	glycogen (starch) synthase activity
LI99_RS29200	COG2244	polysaccharide biosynthetic process
LI99_RS29210	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LI99_RS29230	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
LI99_RS29245	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
LI99_RS29260	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
LI99_RS29265	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
LI99_RS29270	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LI99_RS29280	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LI99_RS29310	COG2030	dehydratase
LI99_RS29315	COG1960	acyl-CoA dehydrogenase activity
LI99_RS29320	COG1960	acyl-CoA dehydrogenase activity
LI99_RS29325	COG2124	cytochrome p450
LI99_RS29330	COG0183	Belongs to the thiolase family
LI99_RS29345	COG1028	Short-chain dehydrogenase reductase Sdr
LI99_RS29350	COG1028	Short-chain dehydrogenase reductase Sdr
LI99_RS29355	COG1024	Enoyl-CoA hydratase
LI99_RS29390	COG0183	Belongs to the thiolase family
LI99_RS29395	COG1309	transcriptional regulator
LI99_RS29405	COG1028	Short-chain dehydrogenase reductase Sdr
LI99_RS29410	COG1960	acyl-CoA dehydrogenase activity
LI99_RS29415	COG0318	PFAM AMP-dependent synthetase and ligase
LI99_RS29420	COG1960	acyl-CoA dehydrogenase activity
LI99_RS29425	COG1960	acyl-CoA dehydrogenase activity
LI99_RS29430	COG1960	acyl-CoA dehydrogenase activity
LI99_RS29435	COG0436	Aminotransferase
LI99_RS29440	COG4214	carbohydrate transport
LI99_RS29450	COG4213	ABC transporter substrate-binding protein
LI99_RS29455	COG2115	Belongs to the xylose isomerase family
LI99_RS29460	COG1940	carbohydrate kinase activity
LI99_RS29475	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LI99_RS29480	COG1028	Short-chain dehydrogenase reductase Sdr
LI99_RS29490	COG0583	DNA-binding transcription factor activity
LI99_RS29510	COG1028	Short-chain dehydrogenase reductase Sdr
LI99_RS29525	COG0346	lactoylglutathione lyase activity
LI99_RS29540	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LI99_RS29550	COG1960	acyl-CoA dehydrogenase activity
LI99_RS29555	COG1309	transcriptional regulator
LI99_RS29565	COG1609	Transcriptional regulator
LI99_RS29575	COG1121	(ABC) transporter
LI99_RS29580	COG0803	Belongs to the bacterial solute-binding protein 9 family
LI99_RS29585	COG0523	cobalamin synthesis protein
LI99_RS29595	COG0803	Belongs to the bacterial solute-binding protein 9 family
LI99_RS29605	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LI99_RS29610	COG1121	(ABC) transporter
LI99_RS29615	COG0778	Nitroreductase
LI99_RS29650	COG0701	Predicted permease
LI99_RS29660	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
LI99_RS29665	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LI99_RS29675	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
LI99_RS29680	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
LI99_RS29685	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LI99_RS29690	COG0227	Belongs to the bacterial ribosomal protein bL28 family
LI99_RS29700	COG0254	rRNA binding
LI99_RS29710	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
LI99_RS29715	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LI99_RS29720	COG0215	cysteine-tRNA ligase activity
LI99_RS29725	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
LI99_RS29730	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
LI99_RS29735	COG1329	Transcriptional regulator
LI99_RS29745	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
LI99_RS29750	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
LI99_RS29760	COG0288	reversible hydration of carbon dioxide
LI99_RS29765	COG1194	a g-specific adenine glycosylase
LI99_RS29810	COG0542	response to heat
LI99_RS29820	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LI99_RS29830	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
LI99_RS29835	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
LI99_RS29865	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
LI99_RS29870	COG0302	gtp cyclohydrolase
LI99_RS29875	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LI99_RS29880	COG2267	carboxylic ester hydrolase activity
LI99_RS29900	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
LI99_RS29915	COG2027	D-alanyl-D-alanine carboxypeptidase
LI99_RS29930	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LI99_RS29935	COG4948	Mandelate Racemase Muconate Lactonizing
LI99_RS29950	COG4608	Belongs to the ABC transporter superfamily
LI99_RS29955	COG0444	Belongs to the ABC transporter superfamily
LI99_RS29960	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LI99_RS29970	COG0747	negative chemotaxis
LI99_RS29975	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LI99_RS29980	COG0583	DNA-binding transcription factor activity
LI99_RS29995	COG0784	Response regulator, receiver
LI99_RS30000	COG4251	negative regulation of phosphorylation
LI99_RS30005	COG0745	RESPONSE REGULATOR receiver
LI99_RS30010	COG4948	Mandelate Racemase Muconate Lactonizing
LI99_RS30015	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LI99_RS30060	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LI99_RS30070	COG5651	PPE family
LI99_RS30100	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LI99_RS30105	COG0596	Alpha beta hydrolase
LI99_RS30115	COG0470	DNA polymerase III
LI99_RS30135	COG1754	DNA topoisomerase type I activity
LI99_RS30135	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LI99_RS30145	COG1278	Cold shock
LI99_RS30150	COG1111	helicase
LI99_RS30150	COG1205	dead DEAH box helicase
LI99_RS30210	COG1414	Transcriptional regulator
LI99_RS30215	COG3734	2-keto-3-deoxy-galactonokinase
LI99_RS30220	COG0800	Aldolase
LI99_RS30225	COG4948	Mandelate Racemase Muconate Lactonizing
LI99_RS30230	COG2271	Major facilitator Superfamily
LI99_RS30240	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LI99_RS30290	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LI99_RS30320	COG1113	amino acid transport
LI99_RS30325	COG0019	diaminopimelate decarboxylase activity
LI99_RS30330	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
LI99_RS30330	COG2508	Transcriptional regulator
LI99_RS30350	COG1408	metallophosphoesterase
LI99_RS30355	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LI99_RS30370	COG2815	serine threonine protein kinase
LI99_RS30370	COG0515	serine threonine protein kinase
LI99_RS30380	COG1946	Acyl-CoA thioesterase
LI99_RS30405	COG3546	catalase activity
LI99_RS30435	COG0714	Associated with various cellular activities
LI99_RS30455	COG1309	transcriptional regulator
LI99_RS30460	COG0477	Major facilitator Superfamily
LI99_RS30465	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
LI99_RS30475	COG1695	Transcriptional regulator
LI99_RS30485	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LI99_RS30490	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LI99_RS30500	COG0753	catalase activity
LI99_RS30505	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
LI99_RS30530	COG4585	Histidine kinase
LI99_RS30535	COG1454	alcohol dehydrogenase
LI99_RS30570	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LI99_RS30575	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
LI99_RS30580	COG0121	glutamine amidotransferase
LI99_RS30585	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LI99_RS30590	COG3572	ergothioneine biosynthetic process
LI99_RS30645	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
LI99_RS30650	COG2218	PFAM glutamate synthase alpha subunit domain protein
LI99_RS30655	COG0069	glutamate synthase activity
LI99_RS30660	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LI99_RS30685	COG2239	Acts as a magnesium transporter
LI99_RS30690	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LI99_RS30695	COG2902	Dehydrogenase
LI99_RS30705	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LI99_RS30710	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LI99_RS30725	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
LI99_RS30730	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
LI99_RS30735	COG0860	N-Acetylmuramoyl-L-alanine amidase
LI99_RS30750	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LI99_RS30760	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LI99_RS30775	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LI99_RS30785	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LI99_RS30790	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LI99_RS30800	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LI99_RS30805	COG0477	Major facilitator Superfamily
LI99_RS30810	COG1063	alcohol dehydrogenase
LI99_RS30815	COG1012	belongs to the aldehyde dehydrogenase family
LI99_RS30825	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LI99_RS30830	COG1802	Transcriptional regulator
LI99_RS30840	COG1793	dna ligase
LI99_RS30845	COG1793	dna ligase
LI99_RS30860	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LI99_RS30875	COG1126	abc transporter atp-binding protein
LI99_RS30885	COG0427	acetyl-CoA hydrolase
LI99_RS30895	COG2124	cytochrome p450
LI99_RS30900	COG0343	queuine tRNA-ribosyltransferase activity
LI99_RS30910	COG0596	Alpha beta hydrolase
LI99_RS30970	COG0590	tRNA wobble adenosine to inosine editing
LI99_RS30980	COG0287	Prephenate dehydrogenase
LI99_RS30990	COG1174	glycine betaine transport
LI99_RS31010	COG5416	Lipopolysaccharide assembly protein A domain
LI99_RS31025	COG1028	Short-chain dehydrogenase reductase Sdr
LI99_RS31030	COG2015	COG2015, Alkyl sulfatase and related hydrolases
LI99_RS31045	COG1733	regulation of RNA biosynthetic process
LI99_RS31085	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LI99_RS31110	COG4977	sequence-specific DNA binding
LI99_RS31135	COG0604	alcohol dehydrogenase
LI99_RS31135	COG3321	synthase
LI99_RS31135	COG1028	Short-chain dehydrogenase reductase Sdr
LI99_RS31155	COG1216	Glycosyl transferase, family 2
LI99_RS31170	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LI99_RS31175	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LI99_RS31185	COG3246	L-lysine catabolic process to acetate
LI99_RS31190	COG0569	domain protein
LI99_RS31230	COG0277	FAD linked oxidase domain protein
LI99_RS31240	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
LI99_RS31245	COG1028	Short-chain dehydrogenase reductase Sdr
LI99_RS31275	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LI99_RS31280	COG3321	synthase
LI99_RS31280	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
LI99_RS31280	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LI99_RS31285	COG0318	PFAM AMP-dependent synthetase and ligase
LI99_RS31290	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
LI99_RS31310	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
LI99_RS31320	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
LI99_RS31325	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
LI99_RS31330	COG0671	phosphoesterase, PA-phosphatase related
LI99_RS31335	COG1216	Glycosyl transferase, family 2
LI99_RS31355	COG0561	phosphatase activity
LI99_RS31365	COG0204	Acyl-transferase
LI99_RS31370	COG2146	nitrite reductase [NAD(P)H] activity
LI99_RS31370	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
LI99_RS31385	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LI99_RS31410	COG0077	Prephenate dehydratase
LI99_RS31435	COG1528	Iron-storage protein
LI99_RS31450	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LI99_RS31450	COG0425	Belongs to the sulfur carrier protein TusA family
LI99_RS31460	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LI99_RS31520	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LI99_RS31525	COG2072	flavoprotein involved in K transport
LI99_RS31530	COG1309	transcriptional regulator
LI99_RS31535	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LI99_RS31550	COG1796	DNA polymerase
LI99_RS31550	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
LI99_RS31580	COG0659	secondary active sulfate transmembrane transporter activity
LI99_RS31585	COG1012	belongs to the aldehyde dehydrogenase family
LI99_RS31615	COG0070	glutamate synthase
LI99_RS31615	COG0069	glutamate synthase activity
LI99_RS31615	COG0067	glutamate synthase
LI99_RS31650	COG0783	Belongs to the Dps family
LI99_RS31670	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
LI99_RS31680	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
LI99_RS31700	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LI99_RS31735	COG0438	transferase activity, transferring glycosyl groups
LI99_RS31740	COG3467	pyridoxamine 5'-phosphate
LI99_RS31745	COG1902	pentaerythritol trinitrate reductase activity
LI99_RS31765	COG2814	Major facilitator Superfamily
LI99_RS31770	COG1012	belongs to the aldehyde dehydrogenase family
LI99_RS31785	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LI99_RS31795	COG1116	anion transmembrane transporter activity
LI99_RS31835	COG1309	transcriptional regulator
LI99_RS31840	COG0778	Nitroreductase
LI99_RS31845	COG1335	isochorismatase
LI99_RS31860	COG1129	ABC transporter
LI99_RS31860	COG0842	Transport permease protein
LI99_RS31865	COG0842	Transport permease protein
LI99_RS31870	COG1960	acyl-CoA dehydrogenase activity
LI99_RS31875	COG1960	acyl-CoA dehydrogenase activity
LI99_RS31880	COG0477	Major facilitator Superfamily
LI99_RS31885	COG3281	Trehalose synthase
LI99_RS31890	COG0366	Alpha amylase catalytic
LI99_RS31905	COG1716	ATPase activity
LI99_RS31915	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
LI99_RS31965	COG1845	cytochrome c oxidase, subunit III
LI99_RS32005	COG1028	Short-chain dehydrogenase reductase Sdr
LI99_RS32015	COG0697	spore germination
LI99_RS32030	COG2208	phosphoserine phosphatase activity
LI99_RS32030	COG2770	Histidine kinase
LI99_RS32040	COG0406	alpha-ribazole phosphatase activity
LI99_RS32045	COG0662	Cupin 2, conserved barrel domain protein
LI99_RS32045	COG2207	Transcriptional regulator
LI99_RS32055	COG0723	plastoquinol--plastocyanin reductase activity
LI99_RS32075	COG1132	(ABC) transporter
LI99_RS32080	COG2375	cellular response to nickel ion
LI99_RS32080	COG1132	(ABC) transporter
LI99_RS32120	COG1960	acyl-CoA dehydrogenase activity
LI99_RS32125	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LI99_RS32130	COG1309	transcriptional regulator
LI99_RS32150	COG2837	iron assimilation
LI99_RS32155	COG2847	Copper chaperone PCu(A)C
LI99_RS32175	COG1403	HNH endonuclease
LI99_RS32180	COG4044	May play a role in the intracellular transport of hydrophobic ligands
LI99_RS32185	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LI99_RS32190	COG3467	pyridoxamine 5'-phosphate
LI99_RS32230	COG1960	acyl-CoA dehydrogenase activity
LI99_RS32235	COG1960	acyl-CoA dehydrogenase activity
LI99_RS32250	COG1643	Atp-dependent helicase
LI99_RS32265	COG0300	oxidoreductase activity
LI99_RS32270	COG3844	kynureninase activity
LI99_RS32275	COG1126	abc transporter atp-binding protein
LI99_RS32280	COG0765	amino acid transport
LI99_RS32285	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LI99_RS32310	COG2801	Transposase and inactivated derivatives
LI99_RS32310	COG3415	Transposase
LI99_RS32320	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LI99_RS32365	COG0714	Associated with various cellular activities
LI99_RS32375	COG1408	metallophosphoesterase
LI99_RS32390	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LI99_RS32395	COG1051	belongs to the nudix hydrolase family
LI99_RS32440	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
LI99_RS32440	COG0778	Nitroreductase
LI99_RS32450	COG0346	lactoylglutathione lyase activity
LI99_RS32475	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
LI99_RS32510	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LI99_RS32515	COG2301	Belongs to the HpcH HpaI aldolase family
LI99_RS32520	COG1396	sequence-specific DNA binding
LI99_RS32520	COG3800	Transcriptional regulator
LI99_RS32530	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
LI99_RS32540	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
LI99_RS32590	COG0596	Alpha beta hydrolase
LI99_RS32610	COG1028	Short-chain dehydrogenase reductase Sdr
LI99_RS32645	COG4149	molybdate abc transporter
LI99_RS32655	COG3842	ATPase activity
LI99_RS32690	COG0583	DNA-binding transcription factor activity
LI99_RS32695	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LI99_RS32730	COG1960	acyl-CoA dehydrogenase activity
LI99_RS32735	COG1012	belongs to the aldehyde dehydrogenase family
LI99_RS32750	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
LI99_RS32755	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
LI99_RS32760	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LI99_RS32800	COG0531	amino acid
LI99_RS32805	COG1012	belongs to the aldehyde dehydrogenase family
LI99_RS32820	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LI99_RS32830	COG0596	Alpha beta hydrolase
LI99_RS32845	COG2814	Major facilitator Superfamily
LI99_RS32850	COG1454	alcohol dehydrogenase
LI99_RS32855	COG3485	protocatechuate 3,4-dioxygenase
LI99_RS32875	COG0673	inositol 2-dehydrogenase activity
LI99_RS32910	COG1122	ATPase activity
LI99_RS32915	COG4721	ABC-type cobalt transport system, permease component
LI99_RS32930	COG0667	Aldo Keto reductase
LI99_RS32950	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LI99_RS32985	COG2515	1-aminocyclopropane-1-carboxylate deaminase
LI99_RS33010	COG2188	Transcriptional regulator
LI99_RS33015	COG0667	Aldo Keto reductase
LI99_RS33025	COG0488	(ABC) transporter
LI99_RS33050	COG1028	Short-chain dehydrogenase reductase Sdr
LI99_RS33065	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LI99_RS33070	COG1414	Transcriptional regulator
LI99_RS33075	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LI99_RS33080	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LI99_RS33085	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
LI99_RS33095	COG0640	Transcriptional regulator
LI99_RS33100	COG0596	Alpha beta hydrolase
LI99_RS33105	COG1309	transcriptional regulator
LI99_RS33130	COG0475	glutathione-regulated potassium exporter activity
LI99_RS33150	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LI99_RS33155	COG1024	Enoyl-CoA hydratase
LI99_RS33215	COG0149	triose-phosphate isomerase activity
LI99_RS33220	COG0698	ribose 5-phosphate isomerase
LI99_RS33225	COG2376	Dihydroxyacetone kinase
LI99_RS33230	COG1802	Transcriptional regulator
LI99_RS33240	COG1250	3-hydroxyacyl-CoA dehydrogenase
LI99_RS33245	COG2610	gluconate transmembrane transporter activity
LI99_RS33260	COG1024	Enoyl-CoA hydratase
LI99_RS33280	COG1609	Transcriptional regulator
LI99_RS33285	COG1072	(Pantothenic acid kinase))
LI99_RS33290	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LI99_RS33310	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LI99_RS33320	COG1309	transcriptional regulator
LI99_RS33330	COG0714	Associated with various cellular activities
LI99_RS33365	COG0243	molybdopterin cofactor binding
LI99_RS33375	COG0446	pyridine nucleotide-disulphide oxidoreductase
LI99_RS33385	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
LI99_RS33400	COG1028	Short-chain dehydrogenase reductase Sdr
LI99_RS33415	COG1620	l-lactate permease
LI99_RS33440	COG0596	Alpha beta hydrolase
LI99_RS33475	COG0596	Alpha beta hydrolase
LI99_RS33490	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
LI99_RS33495	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LI99_RS33500	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
LI99_RS33520	COG3467	pyridoxamine 5'-phosphate
LI99_RS33530	COG2267	carboxylic ester hydrolase activity
LI99_RS33535	COG0657	acetylesterase activity
LI99_RS33545	COG0066	3-isopropylmalate dehydratase activity
LI99_RS33550	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
LI99_RS33560	COG2079	MmgE PrpD family protein
LI99_RS33565	COG1414	Transcriptional regulator
LI99_RS33570	COG0596	Alpha beta hydrolase
LI99_RS33575	COG4221	oxidoreductase activity
LI99_RS33595	COG0235	Class ii aldolase
LI99_RS33605	COG0747	negative chemotaxis
LI99_RS33610	COG0601	transmembrane transport
LI99_RS33615	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LI99_RS33620	COG0444	Belongs to the ABC transporter superfamily
LI99_RS33630	COG1940	carbohydrate kinase activity
LI99_RS33640	COG4948	Mandelate Racemase Muconate Lactonizing
LI99_RS33655	COG1012	belongs to the aldehyde dehydrogenase family
LI99_RS33715	COG1733	regulation of RNA biosynthetic process
LI99_RS33750	COG0359	binds to the 23S rRNA
LI99_RS33755	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
LI99_RS33760	COG0629	single-stranded DNA binding
LI99_RS33765	COG0360	Binds together with S18 to 16S ribosomal RNA
LI99_RS33780	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LI99_RS33800	COG1260	myo-inositol-1-phosphate synthase
LI99_RS33805	COG0596	Alpha beta hydrolase
LI99_RS33805	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LI99_RS33810	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LI99_RS33820	COG0765	amino acid transport
LI99_RS33825	COG1126	abc transporter atp-binding protein
LI99_RS33835	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
LI99_RS33840	COG0300	oxidoreductase activity
LI99_RS33845	COG0495	leucyl-tRNA aminoacylation
LI99_RS33860	COG1678	Uncharacterized ACR, COG1678
LI99_RS33880	COG0617	tRNA 3'-terminal CCA addition
LI99_RS33900	COG1595	DNA-templated transcription, initiation
LI99_RS33920	COG3409	Peptidoglycan-binding domain 1 protein
LI99_RS33920	COG0860	N-Acetylmuramoyl-L-alanine amidase
LI99_RS33935	COG1192	Involved in chromosome partitioning
LI99_RS33940	COG0357	Ribosomal RNA small subunit methyltransferase G
LI99_RS33950	COG0706	membrane insertase activity
LI99_RS33960	COG0594	ribonuclease P activity
LI99_RS33965	COG0230	Belongs to the bacterial ribosomal protein bL34 family
LI99_RS33970	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LI99_RS34010	COG2124	cytochrome p450
LI99_RS34015	COG2124	cytochrome p450
LI99_RS34305	COG2801	Transposase and inactivated derivatives
LI99_RS34380	COG1028	Short-chain dehydrogenase reductase Sdr
LI99_RS34430	COG3328	transposase activity
LI99_RS34540	COG0583	DNA-binding transcription factor activity
LI99_RS34570	COG0765	amino acid transport
LI99_RS34585	COG1316	TRANSCRIPTIONal
LI99_RS34595	COG1028	Short-chain dehydrogenase reductase Sdr