locus-tag	class	description
E5H33_RS00100	COG3845	ABC transporter
E5H33_RS00245	COG0528	UMP kinase activity
E5H33_RS00250	COG0233	cytoplasmic translational termination
E5H33_RS00295	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E5H33_RS00300	COG0084	hydrolase, TatD family'
E5H33_RS00330	COG0230	Belongs to the bacterial ribosomal protein bL34 family
E5H33_RS00380	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E5H33_RS00380	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
E5H33_RS00430	COG1187	pseudouridine synthase activity
E5H33_RS00455	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
E5H33_RS00485	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E5H33_RS00615	COG0698	ribose 5-phosphate isomerase
E5H33_RS00630	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
E5H33_RS00765	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
E5H33_RS00770	COG0280	phosphate acetyltransferase
E5H33_RS00775	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
E5H33_RS00780	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
E5H33_RS00910	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E5H33_RS01090	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E5H33_RS01160	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
E5H33_RS01195	COG0194	GDP metabolic process
E5H33_RS01240	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E5H33_RS01415	COG2255	four-way junction helicase activity
E5H33_RS01690	COG0629	single-stranded DNA binding
E5H33_RS01770	COG1461	Dihydroxyacetone kinase
E5H33_RS01780	COG0571	ribonuclease III activity
E5H33_RS01915	COG0813	purine-nucleoside phosphorylase activity
E5H33_RS01945	COG4221	oxidoreductase activity
E5H33_RS02095	COG0556	nucleotide-excision repair
E5H33_RS02210	COG0355	proton-transporting ATP synthase activity, rotational mechanism
E5H33_RS02215	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
E5H33_RS02435	COG1214	PFAM Peptidase M22, glycoprotease
E5H33_RS02580	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
E5H33_RS02695	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
E5H33_RS02760	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E5H33_RS03015	COG0813	purine-nucleoside phosphorylase activity
E5H33_RS03025	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
E5H33_RS03050	COG1122	ATPase activity
E5H33_RS03080	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
E5H33_RS03090	COG0563	adenylate kinase activity
E5H33_RS03145	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
E5H33_RS03150	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
E5H33_RS03230	COG0051	transcription antitermination factor activity, RNA binding
E5H33_RS03235	COG0776	regulation of translation
E5H33_RS03260	COG1187	pseudouridine synthase activity
E5H33_RS03285	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
E5H33_RS03295	COG0254	rRNA binding
E5H33_RS03310	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
E5H33_RS03375	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E5H33_RS03575	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
E5H33_RS03860	COG1739	Uncharacterized protein family UPF0029
E5H33_RS03895	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
E5H33_RS03905	COG0564	pseudouridine synthase activity
E5H33_RS03935	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
E5H33_RS03965	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
E5H33_RS03970	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
E5H33_RS03980	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
E5H33_RS04025	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
E5H33_RS04170	COG0582	viral genome integration into host DNA
E5H33_RS04220	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
E5H33_RS04225	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
E5H33_RS04235	COG0736	holo-[acyl-carrier-protein] synthase activity
E5H33_RS04400	COG1136	(ABC) transporter