locus-tag	class	description
MCYN_RS00030	COG0335	large ribosomal subunit rRNA binding
MCYN_RS00060	COG1307	EDD domain protein, DegV family
MCYN_RS00065	COG0072	phenylalanine-tRNA ligase activity
MCYN_RS00065	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MCYN_RS00130	COG0233	cytoplasmic translational termination
MCYN_RS00220	COG0563	adenylate kinase activity
MCYN_RS00240	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
MCYN_RS00250	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
MCYN_RS00260	COG0202	RNA polymerase activity
MCYN_RS00280	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
MCYN_RS00340	COG3842	ATPase activity
MCYN_RS00420	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
MCYN_RS00450	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MCYN_RS00455	COG0564	pseudouridine synthase activity
MCYN_RS00470	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
MCYN_RS00625	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
MCYN_RS00635	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
MCYN_RS00730	COG1187	pseudouridine synthase activity
MCYN_RS00785	COG0051	transcription antitermination factor activity, RNA binding
MCYN_RS00790	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
MCYN_RS00800	COG0089	rRNA binding
MCYN_RS00815	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
MCYN_RS00830	COG0255	Belongs to the universal ribosomal protein uL29 family
MCYN_RS00835	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
MCYN_RS00845	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
MCYN_RS00865	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
MCYN_RS00870	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
MCYN_RS00910	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MCYN_RS00935	COG0194	GDP metabolic process
MCYN_RS00960	COG0227	Belongs to the bacterial ribosomal protein bL28 family
MCYN_RS01050	COG0363	glucosamine-6-phosphate deaminase activity
MCYN_RS01120	COG0301	tRNA thio-modification
MCYN_RS01160	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
MCYN_RS01165	COG0222	ribosome binding
MCYN_RS01385	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
MCYN_RS01465	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
MCYN_RS01480	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
MCYN_RS01485	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
MCYN_RS01570	COG0333	Belongs to the bacterial ribosomal protein bL32 family
MCYN_RS01580	COG2255	four-way junction helicase activity
MCYN_RS01605	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
MCYN_RS01660	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
MCYN_RS01820	COG0275	rRNA processing
MCYN_RS01840	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
MCYN_RS01845	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
MCYN_RS01850	COG0758	DNA mediated transformation
MCYN_RS01855	COG0211	Belongs to the bacterial ribosomal protein bL27 family
MCYN_RS01860	COG0261	This protein binds to 23S rRNA in the presence of protein L20
MCYN_RS01875	COG0776	regulation of translation
MCYN_RS01935	COG1428	Deoxynucleoside kinase
MCYN_RS02125	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
MCYN_RS02155	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MCYN_RS02160	COG0742	ribosomal rna small subunit methyltransferase
MCYN_RS02195	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
MCYN_RS02215	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MCYN_RS02215	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MCYN_RS02365	COG0280	phosphate acetyltransferase
MCYN_RS02410	COG0254	rRNA binding
MCYN_RS02515	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
MCYN_RS02575	COG3763	UPF0154 protein
MCYN_RS02600	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MCYN_RS02610	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
MCYN_RS02625	COG0295	cytidine deaminase activity
MCYN_RS02705	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
MCYN_RS03085	COG0217	transcriptional regulatory protein
MCYN_RS03275	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
MCYN_RS03305	COG0544	peptidyl-prolyl cis-trans isomerase activity
MCYN_RS03320	COG0268	Binds directly to 16S ribosomal RNA
MCYN_RS03345	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
MCYN_RS03415	COG0484	heat shock protein binding
MCYN_RS03455	COG1263	PTS System
MCYN_RS03455	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MCYN_RS03455	COG2190	(PTS) system
MCYN_RS03610	COG0698	ribose 5-phosphate isomerase
MCYN_RS03615	COG1187	pseudouridine synthase activity
MCYN_RS03640	COG0571	ribonuclease III activity
MCYN_RS03680	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
MCYN_RS03705	COG0267	Belongs to the bacterial ribosomal protein bL33 family
MCYN_RS03755	COG3118	belongs to the thioredoxin family
MCYN_RS03770	COG1739	Uncharacterized protein family UPF0029
MCYN_RS03785	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MCYN_RS03800	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MCYN_RS03830	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
MCYN_RS03900	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
MCYN_RS03945	COG1122	ATPase activity
MCYN_RS03950	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
MCYN_RS03975	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
MCYN_RS04055	COG0193	aminoacyl-tRNA hydrolase activity