locus-tag	class	description
HR079_RS00020	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
HR079_RS00050	ENOG4108JQ9	ABC transporter
HR079_RS00110	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
HR079_RS00120	ENOG41068ZK	Binds together with S18 to 16S ribosomal RNA (By similarity)
HR079_RS00195	ENOG41060K3	Methyltransferase
HR079_RS00220	ENOG4108Z6B	deaminase
HR079_RS00420	ENOG4108AXB	Binds directly to 16S ribosomal RNA (By similarity)
HR079_RS00590	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
HR079_RS00750	ENOG41082SK	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
HR079_RS00755	ENOG4107URM	50S ribosomal protein l10
HR079_RS00810	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
HR079_RS00830	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
HR079_RS00860	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
HR079_RS00940	ENOG4105CMR	udp-glucose 4-epimerase
HR079_RS01040	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
HR079_RS01120	ENOG4105C3M	thioredoxin reductase
HR079_RS01130	ENOG4105CIE	May be required for sporulation (By similarity)
HR079_RS01150	ENOG4105HX0	Transcriptional regulator
HR079_RS01325	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
HR079_RS01345	ENOG41082I9	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
HR079_RS01350	ENOG4106CUG	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
HR079_RS01355	ENOG4106F7A	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
HR079_RS01370	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
HR079_RS01375	ENOG4105KNM	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
HR079_RS01475	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
HR079_RS01750	ENOG4105KME	endoribonuclease L-psp
HR079_RS01770	ENOG4105D5T	phosphonate abc transporter
HR079_RS01805	ENOG4105KME	endoribonuclease L-psp
HR079_RS01825	ENOG4105D5T	phosphonate abc transporter
HR079_RS01975	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
HR079_RS02050	ENOG4105CMT	Dihydroxyacetone kinase
HR079_RS02055	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
HR079_RS02060	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
HR079_RS02085	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
HR079_RS02120	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HR079_RS02135	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
HR079_RS02140	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
HR079_RS02145	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
HR079_RS02150	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
HR079_RS02160	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
HR079_RS02180	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HR079_RS02190	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HR079_RS02210	ENOG4108JJB	ABC transporter
HR079_RS02235	ENOG4108UJD	30S ribosomal protein S9
HR079_RS02330	ENOG410854A	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
HR079_RS02540	ENOG4105C7H	Helicase, RecD TraA family
HR079_RS02560	ENOG4105E98	transcriptional regulator DeoR family
HR079_RS02695	ENOG4105CI8	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity)
HR079_RS02700	ENOG4107ZRJ	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HR079_RS02710	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HR079_RS02755	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
HR079_RS02825	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
HR079_RS02850	ENOG4105C34	Pseudouridine synthase
HR079_RS02955	ENOG4107ARW	50S ribosomal protein L33
HR079_RS02970	ENOG4107Y7S	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
HR079_RS02975	ENOG4105X36	(ribosomal) protein
HR079_RS02980	ENOG4105K46	50S ribosomal protein l27
HR079_RS03020	ENOG4105DBI	uridine monophosphokinase
HR079_RS03065	ENOG4108A5V	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
HR079_RS03220	ENOG4108RWN	rrna methyltransferase
HR079_RS03270	ENOG4107Z60	histidine triad (HIT) protein
HR079_RS03365	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
HR079_RS03395	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
HR079_RS03440	ENOG410687G	Involved in DNA repair and RecF pathway recombination (By similarity)
HR079_RS03530	ENOG4105DUF	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity)
HR079_RS03600	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
HR079_RS03630	ENOG41082VF	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity)
HR079_RS03635	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HR079_RS03650	ENOG4105CEV	competence damage-inducible protein
HR079_RS03700	ENOG4105MAN	transposase protein A
HR079_RS03710	ENOG4105K70	DNA-binding protein
HR079_RS03825	ENOG4105FE9	pseudouridine synthase
HR079_RS03905	ENOG410853A	UPF0154 protein
HR079_RS04005	ENOG4105VZN	Nucleic-acid-binding protein implicated in transcription termination
HR079_RS04015	ENOG4107EEM	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
HR079_RS04030	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
HR079_RS04075	ENOG4105DTN	riboflavin biosynthesis protein ribF
HR079_RS04245	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
HR079_RS04250	ENOG4105EMU	Dehydrogenase
HR079_RS04270	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
HR079_RS04275	ENOG4107YHV	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
HR079_RS04280	ENOG4105EMU	Dehydrogenase
HR079_RS04380	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
HR079_RS04465	ENOG4107ZJC	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
HR079_RS04480	ENOG4108PSC	Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6-phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator (By similarity)
HR079_RS04500	ENOG4105E15	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HR079_RS04570	ENOG4105E4P	ATPase (AAA
HR079_RS04630	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
HR079_RS04650	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
HR079_RS04875	ENOG4105MAN	transposase protein A
HR079_RS05145	ENOG4108AX8	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)