locus-tag	class	description
HR079_RS00020	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HR079_RS00110	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HR079_RS00120	COG0360	Binds together with S18 to 16S ribosomal RNA
HR079_RS00195	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HR079_RS00220	COG0590	tRNA wobble adenosine to inosine editing
HR079_RS00420	COG0268	Binds directly to 16S ribosomal RNA
HR079_RS00590	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HR079_RS00750	COG0222	ribosome binding
HR079_RS00755	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HR079_RS00810	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HR079_RS00830	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HR079_RS00860	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HR079_RS00940	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HR079_RS01040	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HR079_RS01120	COG0492	ferredoxin-NADP+ reductase activity
HR079_RS01130	COG1481	regulation of sporulation
HR079_RS01325	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HR079_RS01345	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HR079_RS01350	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HR079_RS01355	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HR079_RS01370	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HR079_RS01375	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HR079_RS01440	COG1940	carbohydrate kinase activity
HR079_RS01475	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HR079_RS01750	COG0251	oxidation-reduction process
HR079_RS01805	COG0251	oxidation-reduction process
HR079_RS01975	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HR079_RS02050	COG2376	Dihydroxyacetone kinase
HR079_RS02055	COG0051	transcription antitermination factor activity, RNA binding
HR079_RS02060	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HR079_RS02085	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HR079_RS02120	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HR079_RS02135	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HR079_RS02140	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HR079_RS02145	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HR079_RS02150	COG0200	Binds to the 23S rRNA
HR079_RS02160	COG0563	adenylate kinase activity
HR079_RS02180	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HR079_RS02190	COG0202	RNA polymerase activity
HR079_RS02210	COG1122	ATPase activity
HR079_RS02235	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HR079_RS02330	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HR079_RS02540	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HR079_RS02560	COG1349	DNA-binding transcription factor activity
HR079_RS02665	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HR079_RS02695	COG1420	regulation of RNA biosynthetic process
HR079_RS02700	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HR079_RS02710	COG0484	heat shock protein binding
HR079_RS02755	COG0233	cytoplasmic translational termination
HR079_RS02825	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HR079_RS02850	COG0564	pseudouridine synthase activity
HR079_RS02970	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HR079_RS02975	COG2868	ribosomal protein
HR079_RS02980	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HR079_RS03020	COG0572	uridine kinase
HR079_RS03065	COG0632	four-way junction helicase activity
HR079_RS03220	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HR079_RS03270	COG0537	adenosine 5'-monophosphoramidase activity
HR079_RS03365	COG0416	fatty acid biosynthetic process
HR079_RS03395	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HR079_RS03410	COG0513	Belongs to the DEAD box helicase family
HR079_RS03440	COG1381	Involved in DNA repair and RecF pathway recombination
HR079_RS03530	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HR079_RS03600	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HR079_RS03630	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HR079_RS03650	COG1058	Belongs to the CinA family
HR079_RS03650	COG1546	Belongs to the CinA family
HR079_RS03710	COG0776	regulation of translation
HR079_RS03825	COG1187	pseudouridine synthase activity
HR079_RS03905	COG3763	UPF0154 protein
HR079_RS04005	COG2740	Nucleic-acid-binding protein implicated in transcription termination
HR079_RS04015	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HR079_RS04030	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HR079_RS04075	COG0196	riboflavin kinase activity
HR079_RS04245	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HR079_RS04250	COG4221	oxidoreductase activity
HR079_RS04270	COG0322	excinuclease ABC activity
HR079_RS04275	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HR079_RS04280	COG4221	oxidoreductase activity
HR079_RS04380	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HR079_RS04465	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HR079_RS04500	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HR079_RS04570	COG1373	ATPase (AAA superfamily
HR079_RS04630	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HR079_RS04650	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HR079_RS04650	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HR079_RS05145	COG0594	ribonuclease P activity