locus-tag	class	description
HGG64_RS00020	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HGG64_RS00105	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HGG64_RS00110	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HGG64_RS00125	COG0222	ribosome binding
HGG64_RS00130	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HGG64_RS00150	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HGG64_RS00170	COG0564	pseudouridine synthase activity
HGG64_RS00175	COG1739	Uncharacterized protein family UPF0029
HGG64_RS00250	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HGG64_RS00270	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HGG64_RS00275	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HGG64_RS00290	COG0563	adenylate kinase activity
HGG64_RS00300	COG0200	Binds to the 23S rRNA
HGG64_RS00310	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HGG64_RS00315	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HGG64_RS00340	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HGG64_RS00345	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HGG64_RS00350	COG0255	Belongs to the universal ribosomal protein uL29 family
HGG64_RS00365	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HGG64_RS00380	COG0089	rRNA binding
HGG64_RS00395	COG0051	transcription antitermination factor activity, RNA binding
HGG64_RS00405	COG0254	rRNA binding
HGG64_RS00455	COG0492	ferredoxin-NADP+ reductase activity
HGG64_RS00510	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HGG64_RS00515	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HGG64_RS00555	COG1435	thymidine kinase activity
HGG64_RS00570	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HGG64_RS00595	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HGG64_RS00625	COG0081	regulation of translation
HGG64_RS00940	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HGG64_RS01105	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HGG64_RS01110	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HGG64_RS01115	COG2501	S4 domain
HGG64_RS01175	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HGG64_RS01195	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HGG64_RS01215	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HGG64_RS01220	COG0445	tRNA wobble uridine modification
HGG64_RS01350	COG0194	GDP metabolic process
HGG64_RS01370	COG0556	nucleotide-excision repair
HGG64_RS01425	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HGG64_RS01460	COG0233	cytoplasmic translational termination
HGG64_RS01475	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HGG64_RS01670	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HGG64_RS01675	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HGG64_RS01745	COG0193	aminoacyl-tRNA hydrolase activity
HGG64_RS01760	COG1129	ABC transporter
HGG64_RS01840	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HGG64_RS01840	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HGG64_RS01870	COG1420	regulation of RNA biosynthetic process
HGG64_RS01875	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HGG64_RS01900	COG1481	regulation of sporulation
HGG64_RS01995	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HGG64_RS02070	COG0359	binds to the 23S rRNA
HGG64_RS02100	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HGG64_RS02150	COG0813	purine-nucleoside phosphorylase activity
HGG64_RS02265	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HGG64_RS02270	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HGG64_RS02440	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HGG64_RS02445	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HGG64_RS02460	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HGG64_RS02465	COG0268	Binds directly to 16S ribosomal RNA
HGG64_RS02495	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HGG64_RS02495	COG1263	PTS System
HGG64_RS02530	COG3845	ABC transporter
HGG64_RS02570	COG0360	Binds together with S18 to 16S ribosomal RNA
HGG64_RS02580	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HGG64_RS02620	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HGG64_RS02650	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HGG64_RS02675	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HGG64_RS02690	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HGG64_RS02780	COG0335	large ribosomal subunit rRNA binding
HGG64_RS02790	COG0228	four-way junction DNA binding
HGG64_RS02870	COG2255	four-way junction helicase activity
HGG64_RS02880	COG0124	histidyl-tRNA synthetase
HGG64_RS02895	COG0557	exoribonuclease II activity
HGG64_RS02930	COG1122	ATPase activity
HGG64_RS02985	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HGG64_RS03055	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HGG64_RS03065	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HGG64_RS03070	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HGG64_RS03080	COG0275	rRNA processing
HGG64_RS03085	COG2001	Belongs to the MraZ family