locus-tag	class	description
MSH_RS00085	COG0335	large ribosomal subunit rRNA binding
MSH_RS00160	COG1735	metal-dependent hydrolase with the TIM-barrel fold
MSH_RS00285	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
MSH_RS00295	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
MSH_RS00305	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
MSH_RS00325	COG0556	nucleotide-excision repair
MSH_RS00400	COG0268	Binds directly to 16S ribosomal RNA
MSH_RS00435	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
MSH_RS00510	COG0009	L-threonylcarbamoyladenylate synthase
MSH_RS00510	COG2890	protein-(glutamine-N5) methyltransferase activity
MSH_RS00540	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
MSH_RS00545	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
MSH_RS00680	COG0194	GDP metabolic process
MSH_RS00685	COG0267	Belongs to the bacterial ribosomal protein bL33 family
MSH_RS00905	COG0333	Belongs to the bacterial ribosomal protein bL32 family
MSH_RS01115	COG0363	glucosamine-6-phosphate deaminase activity
MSH_RS01135	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
MSH_RS01465	COG1307	EDD domain protein, DegV family
MSH_RS01505	COG1187	pseudouridine synthase activity
MSH_RS01585	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
MSH_RS01590	COG0557	exoribonuclease II activity
MSH_RS01640	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
MSH_RS01725	COG0275	rRNA processing
MSH_RS01835	COG0084	hydrolase, TatD family'
MSH_RS01860	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
MSH_RS01890	COG0217	transcriptional regulatory protein
MSH_RS01910	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
MSH_RS01970	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
MSH_RS02050	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
MSH_RS02065	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MSH_RS02070	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
MSH_RS02075	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MSH_RS02125	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
MSH_RS02130	COG0222	ribosome binding
MSH_RS02155	COG0359	binds to the 23S rRNA
MSH_RS02205	COG0640	Transcriptional regulator
MSH_RS02270	COG0813	purine-nucleoside phosphorylase activity
MSH_RS02275	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
MSH_RS02425	COG0254	rRNA binding
MSH_RS02495	COG1739	Uncharacterized protein family UPF0029
MSH_RS02585	COG0301	tRNA thio-modification
MSH_RS02630	COG0445	tRNA wobble uridine modification
MSH_RS02635	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
MSH_RS02655	COG1481	regulation of sporulation
MSH_RS02725	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
MSH_RS02815	COG0211	Belongs to the bacterial ribosomal protein bL27 family
MSH_RS02820	COG0261	This protein binds to 23S rRNA in the presence of protein L20
MSH_RS02930	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
MSH_RS02965	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MSH_RS03000	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
MSH_RS03010	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
MSH_RS03020	COG0563	adenylate kinase activity
MSH_RS03090	COG0564	pseudouridine synthase activity
MSH_RS03135	COG3763	UPF0154 protein
MSH_RS03150	COG0291	Belongs to the bacterial ribosomal protein bL35 family
MSH_RS03195	COG0193	aminoacyl-tRNA hydrolase activity
MSH_RS03230	COG0081	regulation of translation
MSH_RS03235	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
MSH_RS03245	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
MSH_RS03250	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
MSH_RS03255	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
MSH_RS03275	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
MSH_RS03280	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
MSH_RS03285	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
MSH_RS03305	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
MSH_RS03320	COG0089	rRNA binding
MSH_RS03330	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
MSH_RS03335	COG0051	transcription antitermination factor activity, RNA binding
MSH_RS03370	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
MSH_RS03375	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
MSH_RS03380	COG0280	phosphate acetyltransferase
MSH_RS03385	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
MSH_RS03425	COG1122	ATPase activity
MSH_RS03470	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MSH_RS03530	COG0233	cytoplasmic translational termination
MSH_RS03630	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
MSH_RS03635	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis