locus-tag	class	description
I6I88_RS00095	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6I88_RS00130	COG0252	asparaginase activity
I6I88_RS00140	COG0084	hydrolase, TatD family'
I6I88_RS00185	COG0814	amino acid
I6I88_RS00210	COG1505	serine-type exopeptidase activity
I6I88_RS00215	COG1028	Short-chain dehydrogenase reductase Sdr
I6I88_RS00225	COG0783	Belongs to the Dps family
I6I88_RS00235	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6I88_RS00240	COG0300	oxidoreductase activity
I6I88_RS00250	COG1960	acyl-CoA dehydrogenase activity
I6I88_RS00275	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I6I88_RS00300	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I6I88_RS00305	COG0228	four-way junction DNA binding
I6I88_RS00335	COG3118	belongs to the thioredoxin family
I6I88_RS00395	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
I6I88_RS00400	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6I88_RS00490	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
I6I88_RS00490	COG3264	Mechanosensitive ion channel
I6I88_RS00500	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I88_RS00505	COG0793	Belongs to the peptidase S41A family
I6I88_RS00510	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
I6I88_RS00520	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6I88_RS00525	COG0791	NLP P60 protein
I6I88_RS00530	COG0658	competence protein
I6I88_RS00530	COG2333	competence protein COMEC
I6I88_RS00545	COG3104	oligopeptide transport
I6I88_RS00560	COG1506	peptidase
I6I88_RS00560	COG0823	Involved in the tonB-independent uptake of proteins
I6I88_RS00575	COG3361	conserved protein (COG2071)
I6I88_RS00585	COG4771	TonB-dependent receptor
I6I88_RS00605	COG2081	HI0933 family
I6I88_RS00655	COG1187	pseudouridine synthase activity
I6I88_RS00660	COG2353	YceI-like domain
I6I88_RS00665	COG1741	Belongs to the pirin family
I6I88_RS00680	COG0436	Aminotransferase
I6I88_RS00685	COG0357	Ribosomal RNA small subunit methyltransferase G
I6I88_RS00700	COG1012	belongs to the aldehyde dehydrogenase family
I6I88_RS00705	COG2967	ApaG domain
I6I88_RS00715	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6I88_RS00720	COG2226	methyltransferase
I6I88_RS00740	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
I6I88_RS00755	COG2989	Protein conserved in bacteria
I6I88_RS00765	COG4771	TonB-dependent receptor
I6I88_RS00775	COG4221	oxidoreductase activity
I6I88_RS00790	COG0754	glutathionylspermidine amidase activity
I6I88_RS00860	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I6I88_RS00865	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6I88_RS00875	COG0326	Molecular chaperone. Has ATPase activity
I6I88_RS00910	COG3112	Uncharacterised protein family (UPF0231)
I6I88_RS00995	COG2801	Transposase and inactivated derivatives
I6I88_RS01000	COG0488	(ABC) transporter
I6I88_RS01045	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I88_RS01055	COG1309	transcriptional regulator
I6I88_RS01080	COG0567	Dehydrogenase, E1 component
I6I88_RS01085	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6I88_RS01095	COG0484	heat shock protein binding
I6I88_RS01100	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6I88_RS01105	COG0232	Belongs to the dGTPase family. Type 2 subfamily
I6I88_RS01115	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I6I88_RS01120	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I6I88_RS01125	COG0612	Peptidase, M16
I6I88_RS01130	COG0612	Peptidase, M16
I6I88_RS01145	COG0629	single-stranded DNA binding
I6I88_RS01150	COG1194	a g-specific adenine glycosylase
I6I88_RS01155	COG0776	regulation of translation
I6I88_RS01160	COG1530	ribonuclease E activity
I6I88_RS01165	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I6I88_RS01170	COG2373	Large extracellular alpha-helical protein
I6I88_RS01180	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I6I88_RS01200	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I6I88_RS01205	COG0017	Asparaginyl-tRNA synthetase
I6I88_RS01210	COG0233	cytoplasmic translational termination
I6I88_RS01215	COG0528	UMP kinase activity
I6I88_RS01235	COG1012	belongs to the aldehyde dehydrogenase family
I6I88_RS01245	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6I88_RS01250	COG1968	undecaprenyl-diphosphatase activity
I6I88_RS01260	COG2177	Part of the ABC transporter FtsEX involved in
I6I88_RS01265	COG0495	leucyl-tRNA aminoacylation
I6I88_RS01280	COG0437	4 iron, 4 sulfur cluster binding
I6I88_RS01310	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6I88_RS01315	COG2255	four-way junction helicase activity
I6I88_RS01320	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6I88_RS01325	COG0281	malic enzyme
I6I88_RS01325	COG0280	phosphate acetyltransferase
I6I88_RS01330	COG0632	four-way junction helicase activity
I6I88_RS01340	COG0509	glycine decarboxylation via glycine cleavage system
I6I88_RS01350	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
I6I88_RS01355	COG0109	protoheme IX farnesyltransferase activity
I6I88_RS01360	COG1845	cytochrome c oxidase, subunit III
I6I88_RS01380	COG1999	signal sequence binding
I6I88_RS01385	COG2322	membrane
I6I88_RS01400	COG1566	PFAM secretion protein HlyD family protein
I6I88_RS01405	COG1214	PFAM Peptidase M22, glycoprotease
I6I88_RS01410	COG0668	transmembrane transport
I6I88_RS01415	COG1331	Highly conserved protein containing a thioredoxin domain
I6I88_RS01440	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6I88_RS01445	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I6I88_RS01465	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6I88_RS01475	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I6I88_RS01485	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I6I88_RS01490	COG0596	Alpha beta hydrolase
I6I88_RS01510	COG1950	PFAM Membrane protein of
I6I88_RS01515	COG0544	peptidyl-prolyl cis-trans isomerase activity
I6I88_RS01525	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I6I88_RS01560	COG1629	transport
I6I88_RS01600	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I6I88_RS01615	COG1428	Deoxynucleoside kinase
I6I88_RS01620	COG0616	signal peptide processing
I6I88_RS01645	COG4717	serine-type aminopeptidase activity
I6I88_RS01660	COG2814	Major facilitator Superfamily
I6I88_RS01665	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6I88_RS01670	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6I88_RS01690	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
I6I88_RS01715	COG0772	Belongs to the SEDS family
I6I88_RS01720	COG0768	penicillin binding
I6I88_RS01735	COG1077	Cell shape determining protein MreB Mrl
I6I88_RS01740	COG0138	bifunctional purine biosynthesis protein purh
I6I88_RS01745	COG0577	efflux transmembrane transporter activity
I6I88_RS01750	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I6I88_RS01755	COG0191	fructose-bisphosphate aldolase activity
I6I88_RS01775	COG2226	methyltransferase
I6I88_RS01785	COG1115	amino acid carrier protein
I6I88_RS01790	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I6I88_RS01800	COG0022	dehydrogenase e1 component
I6I88_RS01800	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6I88_RS01820	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I6I88_RS01830	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6I88_RS01835	COG2086	electron transfer activity
I6I88_RS01840	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I6I88_RS01850	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I6I88_RS01870	COG1428	Deoxynucleoside kinase
I6I88_RS01875	COG1131	(ABC) transporter
I6I88_RS01885	COG0730	response to heat
I6I88_RS01890	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
I6I88_RS01895	COG1162	GTPase activity
I6I88_RS01920	COG1490	D-aminoacyl-tRNA deacylase activity
I6I88_RS01940	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I6I88_RS01945	COG3844	kynureninase activity
I6I88_RS01950	COG0010	Belongs to the arginase family
I6I88_RS01960	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6I88_RS01965	COG0433	COG0433 Predicted ATPase
I6I88_RS02005	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6I88_RS02045	COG1690	Belongs to the RtcB family
I6I88_RS02075	COG0501	Belongs to the peptidase M48B family
I6I88_RS02080	COG1704	LemA family
I6I88_RS02135	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I6I88_RS02140	COG4771	TonB-dependent receptor
I6I88_RS02150	COG0745	RESPONSE REGULATOR receiver
I6I88_RS02155	COG0346	lactoylglutathione lyase activity
I6I88_RS02185	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I88_RS02190	COG0343	queuine tRNA-ribosyltransferase activity
I6I88_RS02205	COG0825	malonyl-CoA metabolic process
I6I88_RS02210	COG0305	Participates in initiation and elongation during chromosome replication
I6I88_RS02215	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6I88_RS02225	COG0688	phosphatidylethanolamine metabolic process
I6I88_RS02240	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6I88_RS02245	COG0799	negative regulation of ribosome biogenesis
I6I88_RS02255	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6I88_RS02285	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I6I88_RS02295	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I6I88_RS02300	COG2211	Major facilitator Superfamily
I6I88_RS02360	COG1028	Short-chain dehydrogenase reductase Sdr
I6I88_RS02365	COG1192	Involved in chromosome partitioning
I6I88_RS02370	COG1475	DNA binding
I6I88_RS02380	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I6I88_RS02395	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6I88_RS02405	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I6I88_RS02410	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6I88_RS02415	COG2217	Heavy metal translocating P-type atpase
I6I88_RS02425	COG3278	Belongs to the heme-copper respiratory oxidase family
I6I88_RS02440	COG0348	domain, Protein
I6I88_RS02465	COG1858	cytochrome C peroxidase
I6I88_RS02470	COG5002	protein histidine kinase activity
I6I88_RS02470	COG2176	DNA-directed DNA polymerase activity
I6I88_RS02475	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6I88_RS02485	COG1546	Belongs to the CinA family
I6I88_RS02485	COG1058	Belongs to the CinA family
I6I88_RS02490	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I6I88_RS02495	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6I88_RS02505	COG0552	protein localization to endoplasmic reticulum
I6I88_RS02530	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
I6I88_RS02540	COG1733	regulation of RNA biosynthetic process
I6I88_RS02545	COG2814	Major facilitator Superfamily
I6I88_RS02555	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I6I88_RS02575	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I6I88_RS02580	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6I88_RS02590	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I6I88_RS02595	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I6I88_RS02615	COG2814	Major facilitator Superfamily
I6I88_RS02650	COG2807	transmembrane transport
I6I88_RS02660	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I6I88_RS02675	COG0420	3'-5' exonuclease activity
I6I88_RS02680	COG0419	ATPase involved in DNA repair
I6I88_RS02690	COG0848	biopolymer transport protein
I6I88_RS02695	COG0811	peptide transport
I6I88_RS02700	COG2223	nitrite transmembrane transporter activity
I6I88_RS02735	COG2759	Belongs to the formate--tetrahydrofolate ligase family
I6I88_RS02750	COG2801	Transposase and inactivated derivatives
I6I88_RS02755	COG2824	Alkylphosphonate utilization operon protein PhnA
I6I88_RS02825	COG2217	Heavy metal translocating P-type atpase
I6I88_RS02835	COG3047	cAMP biosynthetic process
I6I88_RS02850	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I6I88_RS02860	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
I6I88_RS02865	COG2949	membrane
I6I88_RS02870	COG0513	Belongs to the DEAD box helicase family
I6I88_RS02875	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I6I88_RS02875	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I6I88_RS02880	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I6I88_RS02880	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I6I88_RS02890	COG0572	uridine kinase
I6I88_RS02900	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6I88_RS02920	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6I88_RS02930	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I6I88_RS02935	COG0513	Belongs to the DEAD box helicase family
I6I88_RS02940	COG0791	NLP P60 protein
I6I88_RS02945	COG0183	Belongs to the thiolase family
I6I88_RS02995	COG1881	PFAM PEBP family protein
I6I88_RS03000	COG1733	regulation of RNA biosynthetic process
I6I88_RS03005	COG0778	Nitroreductase
I6I88_RS03045	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6I88_RS03055	COG3279	Response regulator of the LytR AlgR family
I6I88_RS03065	COG1408	metallophosphoesterase
I6I88_RS03070	COG0488	(ABC) transporter
I6I88_RS03080	COG0133	tryptophan synthase activity
I6I88_RS03085	COG1733	regulation of RNA biosynthetic process
I6I88_RS03090	COG2814	Major facilitator Superfamily
I6I88_RS03095	COG0488	(ABC) transporter
I6I88_RS03105	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I88_RS03125	COG2326	polyphosphate kinase activity
I6I88_RS03135	COG0534	Mate efflux family protein
I6I88_RS03145	COG2223	nitrite transmembrane transporter activity
I6I88_RS03150	COG2239	Acts as a magnesium transporter
I6I88_RS03165	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6I88_RS03170	COG0230	Belongs to the bacterial ribosomal protein bL34 family
I6I88_RS03175	COG2197	response regulator
I6I88_RS03195	COG0577	efflux transmembrane transporter activity
I6I88_RS03200	COG0124	histidyl-tRNA synthetase
I6I88_RS03340	COG2733	membrane
I6I88_RS03345	COG0564	pseudouridine synthase activity
I6I88_RS03360	COG0702	epimerase
I6I88_RS03365	COG4771	TonB-dependent receptor
I6I88_RS03385	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6I88_RS03390	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I6I88_RS03440	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I6I88_RS03455	COG1663	tetraacyldisaccharide 4'-kinase activity
I6I88_RS03475	COG1187	pseudouridine synthase activity
I6I88_RS03505	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6I88_RS03510	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6I88_RS03530	COG0149	triose-phosphate isomerase activity
I6I88_RS03555	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6I88_RS03565	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
I6I88_RS03570	COG0339	signal peptide processing
I6I88_RS03630	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6I88_RS03640	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I88_RS03645	COG1063	alcohol dehydrogenase
I6I88_RS03650	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I6I88_RS03655	COG1674	ftsk spoiiie
I6I88_RS03670	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6I88_RS03670	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6I88_RS03695	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6I88_RS03740	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6I88_RS03775	COG2885	chlorophyll binding
I6I88_RS03820	COG3842	ATPase activity
I6I88_RS03830	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I6I88_RS03840	COG4974	Belongs to the 'phage' integrase family
I6I88_RS03845	COG1418	mRNA catabolic process
I6I88_RS03890	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I6I88_RS03895	COG0784	Response regulator, receiver
I6I88_RS03895	COG2205	protein histidine kinase activity
I6I88_RS03895	COG5002	protein histidine kinase activity
I6I88_RS03905	COG1960	acyl-CoA dehydrogenase activity
I6I88_RS03915	COG0285	dihydrofolate synthase activity
I6I88_RS03960	COG0018	arginyl-trna synthetase
I6I88_RS03970	COG0791	NLP P60 protein
I6I88_RS03970	COG1388	LysM domain
I6I88_RS03975	COG1696	Membrane protein involved in D-alanine export
I6I88_RS03995	COG1538	Outer membrane efflux protein
I6I88_RS04005	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I88_RS04010	COG0606	chelatase, subunit chli
I6I88_RS04020	COG2321	neutral zinc metallopeptidase
I6I88_RS04030	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I6I88_RS04035	COG0217	transcriptional regulatory protein
I6I88_RS04040	COG0564	pseudouridine synthase activity
I6I88_RS04045	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
I6I88_RS04125	COG1760	l-serine dehydratase
I6I88_RS04130	COG0443	Heat shock 70 kDa protein
I6I88_RS04170	COG3275	phosphorelay sensor kinase activity
I6I88_RS04180	COG3279	Response regulator of the LytR AlgR family
I6I88_RS04185	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6I88_RS04190	COG0427	acetyl-CoA hydrolase
I6I88_RS04205	COG2363	Small membrane protein
I6I88_RS04215	COG2252	PERMEase
I6I88_RS04220	COG1063	alcohol dehydrogenase
I6I88_RS04225	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6I88_RS04230	COG1611	Belongs to the LOG family
I6I88_RS04235	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6I88_RS04240	COG0205	6-phosphofructokinase activity
I6I88_RS04255	COG1803	Methylglyoxal synthase
I6I88_RS04260	COG0251	oxidation-reduction process
I6I88_RS04270	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6I88_RS04285	COG2181	nitrate reductase activity
I6I88_RS04285	COG0247	lactate metabolic process
I6I88_RS04295	COG1472	Belongs to the glycosyl hydrolase 3 family
I6I88_RS04300	COG0438	transferase activity, transferring glycosyl groups
I6I88_RS04305	COG1917	Cupin 2, conserved barrel domain protein
I6I88_RS04305	COG4977	sequence-specific DNA binding
I6I88_RS04310	COG0666	response to abiotic stimulus
I6I88_RS04315	COG0402	S-adenosylhomocysteine deaminase activity
I6I88_RS04325	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
I6I88_RS04335	COG2885	chlorophyll binding
I6I88_RS04340	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6I88_RS04360	COG4974	Belongs to the 'phage' integrase family
I6I88_RS04375	COG0431	NADPH-dependent FMN reductase
I6I88_RS04385	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
I6I88_RS04390	COG0540	Belongs to the ATCase OTCase family
I6I88_RS04400	COG1234	tRNA 3'-trailer cleavage
I6I88_RS04405	COG0259	pyridoxamine-phosphate oxidase activity
I6I88_RS04455	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I6I88_RS04460	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I6I88_RS04465	COG0579	oxidoreductase
I6I88_RS04480	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I6I88_RS04495	COG3275	phosphorelay sensor kinase activity
I6I88_RS04505	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I88_RS04540	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I88_RS04645	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6I88_RS04650	COG0581	inorganic phosphate transmembrane transporter activity
I6I88_RS04655	COG0573	inorganic phosphate transmembrane transporter activity
I6I88_RS04735	COG1012	belongs to the aldehyde dehydrogenase family
I6I88_RS04775	COG0167	dihydroorotate dehydrogenase activity
I6I88_RS04785	COG1733	regulation of RNA biosynthetic process
I6I88_RS04790	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I6I88_RS04795	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I6I88_RS04800	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I6I88_RS04805	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I6I88_RS04850	COG2884	Cell division ATP-binding protein ftsE
I6I88_RS04870	COG4206	TonB-dependent receptor
I6I88_RS04870	COG1629	transport
I6I88_RS04885	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I6I88_RS04890	COG2814	Major facilitator Superfamily
I6I88_RS04905	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I6I88_RS04910	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6I88_RS04920	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6I88_RS04930	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6I88_RS04935	COG0673	inositol 2-dehydrogenase activity
I6I88_RS04940	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
I6I88_RS04965	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I6I88_RS05000	COG1959	2 iron, 2 sulfur cluster binding
I6I88_RS05040	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I6I88_RS05075	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I6I88_RS05095	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6I88_RS05115	COG3851	Histidine kinase
I6I88_RS05130	COG2076	Multidrug Resistance protein
I6I88_RS05145	COG0321	lipoyl(octanoyl) transferase activity
I6I88_RS05145	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I6I88_RS05175	COG0517	IMP dehydrogenase activity
I6I88_RS05175	COG0516	GMP reductase activity
I6I88_RS05195	COG2197	response regulator
I6I88_RS05240	COG0156	8-amino-7-oxononanoate synthase activity
I6I88_RS05255	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6I88_RS05260	COG0431	NADPH-dependent FMN reductase
I6I88_RS05340	COG4106	trans-aconitate 2-methyltransferase activity
I6I88_RS05370	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I6I88_RS05375	COG1846	Transcriptional regulator
I6I88_RS05480	COG0513	Belongs to the DEAD box helicase family
I6I88_RS05485	COG1917	Cupin 2, conserved barrel domain protein
I6I88_RS05485	COG2207	Transcriptional regulator
I6I88_RS05575	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I6I88_RS05580	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I6I88_RS05625	COG0537	adenosine 5'-monophosphoramidase activity
I6I88_RS05655	COG0717	Belongs to the dCTP deaminase family
I6I88_RS05695	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I6I88_RS05730	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6I88_RS05740	COG2194	sulfuric ester hydrolase activity
I6I88_RS05775	COG1506	peptidase
I6I88_RS05775	COG0823	Involved in the tonB-independent uptake of proteins
I6I88_RS05785	COG0833	amino acid
I6I88_RS05810	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I6I88_RS05820	COG0513	Belongs to the DEAD box helicase family
I6I88_RS05830	COG0488	(ABC) transporter
I6I88_RS05835	COG1278	Cold shock
I6I88_RS05845	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I6I88_RS05850	COG2801	Transposase and inactivated derivatives
I6I88_RS05865	COG3279	Response regulator of the LytR AlgR family
I6I88_RS05870	COG3275	phosphorelay sensor kinase activity
I6I88_RS05885	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I6I88_RS05890	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I6I88_RS05900	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I6I88_RS05940	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I6I88_RS05950	COG0438	transferase activity, transferring glycosyl groups
I6I88_RS05950	COG0297	glycogen (starch) synthase activity
I6I88_RS05955	COG1216	Glycosyl transferase, family 2
I6I88_RS05955	COG0463	Glycosyl transferase, family 2
I6I88_RS05960	COG0110	maltose O-acetyltransferase activity
I6I88_RS05980	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6I88_RS05995	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6I88_RS06070	COG0617	tRNA 3'-terminal CCA addition
I6I88_RS06075	COG0009	L-threonylcarbamoyladenylate synthase
I6I88_RS06090	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I6I88_RS06160	COG0666	response to abiotic stimulus
I6I88_RS06185	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6I88_RS06200	COG1733	regulation of RNA biosynthetic process
I6I88_RS06205	COG0494	nUDIX hydrolase
I6I88_RS06220	COG0288	reversible hydration of carbon dioxide
I6I88_RS06235	COG0534	Mate efflux family protein
I6I88_RS06245	COG4206	TonB-dependent receptor
I6I88_RS06255	COG2819	hydrolase of the alpha beta superfamily
I6I88_RS06275	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6I88_RS06285	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6I88_RS06305	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I6I88_RS06315	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6I88_RS06325	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6I88_RS06335	COG0714	Associated with various cellular activities
I6I88_RS06360	COG1714	RDD family
I6I88_RS06365	COG2860	membrane
I6I88_RS06375	COG0424	maF-like protein
I6I88_RS06400	COG0556	nucleotide-excision repair
I6I88_RS06410	COG2814	Major facilitator Superfamily
I6I88_RS06420	COG1917	Cupin 2, conserved barrel domain protein
I6I88_RS06420	COG2207	Transcriptional regulator
I6I88_RS06445	COG0642	Histidine kinase
I6I88_RS06450	COG0745	RESPONSE REGULATOR receiver
I6I88_RS06475	COG0492	ferredoxin-NADP+ reductase activity
I6I88_RS06490	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6I88_RS06490	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6I88_RS06545	COG0456	acetyltransferase
I6I88_RS06550	COG2207	Transcriptional regulator
I6I88_RS06595	COG4263	nitrous-oxide reductase activity
I6I88_RS06605	COG3278	Belongs to the heme-copper respiratory oxidase family
I6I88_RS06645	COG0688	phosphatidylethanolamine metabolic process
I6I88_RS06665	COG3279	Response regulator of the LytR AlgR family
I6I88_RS06680	COG2194	sulfuric ester hydrolase activity
I6I88_RS06685	COG0671	phosphoesterase, PA-phosphatase related
I6I88_RS06700	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6I88_RS06705	COG3279	Response regulator of the LytR AlgR family
I6I88_RS06710	COG3275	phosphorelay sensor kinase activity
I6I88_RS06720	COG4771	TonB-dependent receptor
I6I88_RS06725	COG4676	Protein conserved in bacteria
I6I88_RS06735	COG2076	Multidrug Resistance protein
I6I88_RS06755	COG4753	response regulator
I6I88_RS06755	COG2207	Transcriptional regulator
I6I88_RS06770	COG0789	Transcriptional regulator
I6I88_RS06775	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I6I88_RS06790	COG1917	Cupin 2, conserved barrel domain protein
I6I88_RS06790	COG2207	Transcriptional regulator
I6I88_RS06795	COG1064	alcohol dehydrogenase
I6I88_RS06800	COG0640	Transcriptional regulator
I6I88_RS06825	COG3237	CsbD-like
I6I88_RS06835	COG1028	Short-chain dehydrogenase reductase Sdr
I6I88_RS06865	COG4585	Histidine kinase
I6I88_RS06870	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
I6I88_RS06875	COG0583	DNA-binding transcription factor activity
I6I88_RS06880	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6I88_RS06890	COG0667	Aldo Keto reductase
I6I88_RS06900	COG1619	proteins homologs of microcin C7 resistance protein MccF
I6I88_RS06905	COG1335	isochorismatase
I6I88_RS06910	COG0697	spore germination
I6I88_RS06925	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I88_RS06940	COG0431	NADPH-dependent FMN reductase
I6I88_RS06955	COG2814	Major facilitator Superfamily
I6I88_RS06960	COG1733	regulation of RNA biosynthetic process
I6I88_RS06975	COG1538	Outer membrane efflux protein
I6I88_RS06980	COG0069	glutamate synthase activity
I6I88_RS06985	COG2365	Tyrosine phosphatase family
I6I88_RS07005	COG0655	NAD(P)H dehydrogenase (quinone) activity
I6I88_RS07015	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6I88_RS07025	COG0702	epimerase
I6I88_RS07040	COG4221	oxidoreductase activity
I6I88_RS07045	COG2207	Transcriptional regulator
I6I88_RS07060	COG3550	peptidyl-serine autophosphorylation
I6I88_RS07065	COG3550	peptidyl-serine autophosphorylation
I6I88_RS07070	COG1396	sequence-specific DNA binding
I6I88_RS07130	COG2885	chlorophyll binding
I6I88_RS07140	COG0513	Belongs to the DEAD box helicase family
I6I88_RS07180	COG1446	asparaginase
I6I88_RS07185	COG4242	Belongs to the peptidase S51 family
I6I88_RS07195	COG0069	glutamate synthase activity
I6I88_RS07205	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I6I88_RS07215	COG0805	protein transport
I6I88_RS07235	COG0798	PFAM Bile acid sodium symporter
I6I88_RS07350	COG1846	Transcriptional regulator
I6I88_RS07385	COG2351	hydroxyisourate hydrolase activity
I6I88_RS07410	COG2197	response regulator
I6I88_RS07435	COG1629	transport
I6I88_RS07480	COG2003	Belongs to the UPF0758 family
I6I88_RS07510	COG2319	Wd-40 repeat
I6I88_RS07510	COG3903	Transcriptional regulator
I6I88_RS07595	COG0582	viral genome integration into host DNA
I6I88_RS07600	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
I6I88_RS07620	COG4974	Belongs to the 'phage' integrase family
I6I88_RS07655	COG1028	Short-chain dehydrogenase reductase Sdr
I6I88_RS07660	COG2226	methyltransferase
I6I88_RS07720	COG0009	L-threonylcarbamoyladenylate synthase
I6I88_RS07725	COG0045	succinate-CoA ligase (ADP-forming) activity
I6I88_RS07735	COG0542	response to heat
I6I88_RS07740	COG3118	belongs to the thioredoxin family
I6I88_RS07755	COG1132	(ABC) transporter
I6I88_RS07765	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6I88_RS07795	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I6I88_RS07800	COG0242	peptide deformylase activity
I6I88_RS07810	COG3956	TIGRFAM MazG family protein
I6I88_RS07825	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6I88_RS07850	COG3015	lipoprotein NlpE involved in copper resistance
I6I88_RS07855	COG1575	Belongs to the MenA family. Type 1 subfamily
I6I88_RS07860	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I6I88_RS07875	COG1960	acyl-CoA dehydrogenase activity
I6I88_RS07880	COG0183	Belongs to the thiolase family
I6I88_RS07885	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6I88_RS07885	COG1024	Enoyl-CoA hydratase
I6I88_RS07890	COG1846	Transcriptional regulator
I6I88_RS07910	COG3179	chitinase
I6I88_RS07920	COG1999	signal sequence binding
I6I88_RS07930	COG2207	Transcriptional regulator
I6I88_RS07970	COG0022	dehydrogenase e1 component
I6I88_RS07975	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I6I88_RS07985	COG0022	dehydrogenase e1 component
I6I88_RS07990	COG0156	8-amino-7-oxononanoate synthase activity
I6I88_RS08005	COG2814	Major facilitator Superfamily
I6I88_RS08010	COG1363	Peptidase, m42
I6I88_RS08020	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6I88_RS08030	COG2996	Protein conserved in bacteria
I6I88_RS08045	COG2079	MmgE PrpD family protein
I6I88_RS08055	COG1960	acyl-CoA dehydrogenase activity
I6I88_RS08060	COG1024	Enoyl-CoA hydratase
I6I88_RS08070	COG1024	Enoyl-CoA hydratase
I6I88_RS08120	COG2197	response regulator
I6I88_RS08125	COG2059	Chromate
I6I88_RS08145	COG4753	response regulator
I6I88_RS08145	COG2207	Transcriptional regulator
I6I88_RS08155	COG1193	negative regulation of DNA recombination
I6I88_RS08160	COG4106	trans-aconitate 2-methyltransferase activity
I6I88_RS08205	COG2910	NAD(P)H-binding
I6I88_RS08220	COG1063	alcohol dehydrogenase
I6I88_RS08225	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6I88_RS08240	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I6I88_RS08255	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I88_RS08260	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
I6I88_RS08290	COG0831	urea catabolic process
I6I88_RS08295	COG0832	Belongs to the urease beta subunit family
I6I88_RS08300	COG0804	urea catabolic process
I6I88_RS08305	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
I6I88_RS08310	COG0830	nickel cation binding
I6I88_RS08315	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I6I88_RS08320	COG0829	nickel cation binding
I6I88_RS08325	COG4413	Urea transporter
I6I88_RS08365	COG1574	metal-dependent hydrolase with the TIM-barrel fold
I6I88_RS08370	COG1335	isochorismatase
I6I88_RS08375	COG2353	YceI-like domain
I6I88_RS08380	COG1741	Belongs to the pirin family
I6I88_RS08420	COG4716	Myosin-crossreactive antigen
I6I88_RS08435	COG0038	chloride channel
I6I88_RS08440	COG4977	sequence-specific DNA binding
I6I88_RS08440	COG1917	Cupin 2, conserved barrel domain protein
I6I88_RS08475	COG3634	alkyl hydroperoxide reductase activity
I6I88_RS08500	COG2885	chlorophyll binding
I6I88_RS08535	COG0671	phosphoesterase, PA-phosphatase related
I6I88_RS08610	COG1607	acyl-coa hydrolase
I6I88_RS08620	COG2890	protein-(glutamine-N5) methyltransferase activity
I6I88_RS08625	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6I88_RS08625	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6I88_RS08630	COG1739	Uncharacterized protein family UPF0029
I6I88_RS08635	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6I88_RS08645	COG0697	spore germination
I6I88_RS08660	COG1858	cytochrome C peroxidase
I6I88_RS08685	COG2885	chlorophyll binding
I6I88_RS08715	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6I88_RS08725	COG0284	orotidine-5'-phosphate decarboxylase activity
I6I88_RS08730	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I6I88_RS08750	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6I88_RS08755	COG5006	permease, DMT superfamily
I6I88_RS08770	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I88_RS08775	COG0697	spore germination
I6I88_RS08780	COG0477	Major facilitator Superfamily
I6I88_RS08785	COG1120	ATPase activity
I6I88_RS08790	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I88_RS08815	COG0183	Belongs to the thiolase family
I6I88_RS08820	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6I88_RS08830	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6I88_RS08845	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6I88_RS08885	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6I88_RS08915	COG1295	ribonuclease BN
I6I88_RS08925	COG0012	GTP binding
I6I88_RS08965	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I6I88_RS09000	COG2885	chlorophyll binding
I6I88_RS09040	COG0482	sulfurtransferase activity
I6I88_RS09060	COG0706	membrane insertase activity
I6I88_RS09065	COG0504	CTP synthase activity
I6I88_RS09070	COG1368	sulfuric ester hydrolase activity
I6I88_RS09075	COG3552	Protein containing von Willebrand factor type A (VWA) domain
I6I88_RS09085	COG0714	Associated with various cellular activities
I6I88_RS09100	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I88_RS09120	COG0730	response to heat
I6I88_RS09135	COG1566	PFAM secretion protein HlyD family protein
I6I88_RS09150	COG2814	Major facilitator Superfamily
I6I88_RS09255	COG1252	NADH dehydrogenase
I6I88_RS09260	COG3530	Putative quorum-sensing-regulated virulence factor
I6I88_RS09275	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6I88_RS09275	COG0519	Catalyzes the synthesis of GMP from XMP
I6I88_RS09280	COG0786	glutamate:sodium symporter activity
I6I88_RS09290	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6I88_RS09295	COG1028	Short-chain dehydrogenase reductase Sdr
I6I88_RS09300	COG2234	aminopeptidase activity
I6I88_RS09310	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
I6I88_RS09395	COG0512	Glutamine amidotransferase of anthranilate synthase
I6I88_RS09400	COG0477	Major facilitator Superfamily
I6I88_RS09405	COG0475	glutathione-regulated potassium exporter activity
I6I88_RS09430	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6I88_RS09435	COG1136	(ABC) transporter
I6I88_RS09465	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6I88_RS09505	COG3189	MarR family transcriptional regulator
I6I88_RS09530	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I6I88_RS09545	COG2877	3-deoxy-8-phosphooctulonate synthase activity
I6I88_RS09560	COG4607	ABC-type enterochelin transport system periplasmic component
I6I88_RS09565	COG4604	ABC transporter, ATP-binding protein
I6I88_RS09570	COG4605	iron ion homeostasis
I6I88_RS09575	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I88_RS09600	COG3457	Alanine racemase
I6I88_RS09615	COG0598	Magnesium transport protein CorA
I6I88_RS09620	COG1228	amidohydrolase
I6I88_RS09625	COG0010	Belongs to the arginase family
I6I88_RS09630	COG0745	RESPONSE REGULATOR receiver
I6I88_RS09635	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I6I88_RS09645	COG0628	permease
I6I88_RS09655	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6I88_RS09665	COG0038	chloride channel
I6I88_RS09675	COG1045	serine acetyltransferase
I6I88_RS09685	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
I6I88_RS09750	COG3059	membrane
I6I88_RS09755	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6I88_RS09755	COG2207	Transcriptional regulator
I6I88_RS09765	COG2205	protein histidine kinase activity
I6I88_RS09775	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
I6I88_RS09785	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
I6I88_RS09795	COG2204	response regulator
I6I88_RS09810	COG4771	TonB-dependent receptor
I6I88_RS09900	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I6I88_RS09910	COG0738	Major facilitator superfamily
I6I88_RS09970	COG0356	it plays a direct role in the translocation of protons across the membrane
I6I88_RS09975	COG2076	Multidrug Resistance protein
I6I88_RS10080	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
I6I88_RS10165	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I6I88_RS10170	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I6I88_RS10175	COG0215	cysteine-tRNA ligase activity
I6I88_RS10180	COG0302	gtp cyclohydrolase
I6I88_RS10200	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I6I88_RS10220	COG1741	Belongs to the pirin family
I6I88_RS10230	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6I88_RS10240	COG1368	sulfuric ester hydrolase activity
I6I88_RS10245	COG0745	RESPONSE REGULATOR receiver
I6I88_RS10250	COG5002	protein histidine kinase activity
I6I88_RS10255	COG4574	serine-type endopeptidase inhibitor activity
I6I88_RS10260	COG2205	protein histidine kinase activity
I6I88_RS10265	COG4585	Histidine kinase
I6I88_RS10275	COG2176	DNA-directed DNA polymerase activity
I6I88_RS10295	COG4628	conserved protein (DUF2132)
I6I88_RS10300	COG0545	Peptidyl-prolyl cis-trans isomerase
I6I88_RS10310	COG1899	peptidyl-lysine modification to peptidyl-hypusine
I6I88_RS10315	COG0387	Pfam Sodium calcium exchanger
I6I88_RS10345	COG2197	response regulator
I6I88_RS10350	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6I88_RS10355	COG0363	glucosamine-6-phosphate deaminase activity
I6I88_RS10360	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6I88_RS10370	COG0187	DNA topoisomerase II activity
I6I88_RS10390	COG0427	acetyl-CoA hydrolase
I6I88_RS10405	COG1193	negative regulation of DNA recombination
I6I88_RS10410	COG3011	Protein conserved in bacteria
I6I88_RS10425	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6I88_RS10430	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6I88_RS10435	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6I88_RS10440	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6I88_RS10440	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
I6I88_RS10445	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6I88_RS10450	COG1078	dGTPase activity
I6I88_RS10455	COG2986	histidine ammonia-lyase
I6I88_RS10460	COG3022	response to hydroperoxide
I6I88_RS10470	COG1522	sequence-specific DNA binding
I6I88_RS10485	COG1253	flavin adenine dinucleotide binding
I6I88_RS10490	COG0542	response to heat
I6I88_RS10495	COG4067	protein conserved in archaea
I6I88_RS10495	COG0189	ligase activity
I6I88_RS10505	COG0288	reversible hydration of carbon dioxide
I6I88_RS10515	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I6I88_RS10540	COG0306	phosphate transporter
I6I88_RS10555	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6I88_RS10565	COG2855	membrane
I6I88_RS10570	COG0583	DNA-binding transcription factor activity
I6I88_RS10595	COG1757	Na H antiporter
I6I88_RS10600	COG0450	alkyl hydroperoxide reductase
I6I88_RS10630	COG2217	Heavy metal translocating P-type atpase
I6I88_RS10665	COG0006	proline dipeptidase activity
I6I88_RS10675	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
I6I88_RS10685	COG2171	N-acyltransferase activity
I6I88_RS10690	COG1368	sulfuric ester hydrolase activity
I6I88_RS10700	COG0463	Glycosyl transferase, family 2
I6I88_RS10710	COG0047	phosphoribosylformylglycinamidine synthase activity
I6I88_RS10710	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6I88_RS10720	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6I88_RS10880	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I6I88_RS10915	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6I88_RS10925	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I88_RS10935	COG0667	Aldo Keto reductase
I6I88_RS10940	COG0519	Catalyzes the synthesis of GMP from XMP
I6I88_RS10950	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
I6I88_RS10960	COG2070	2-Nitropropane dioxygenase
I6I88_RS10970	COG1280	lysine exporter protein (LysE YggA)
I6I88_RS10980	COG0251	oxidation-reduction process
I6I88_RS10990	COG2814	Major facilitator Superfamily
I6I88_RS10995	COG0640	Transcriptional regulator
I6I88_RS11010	COG1629	transport
I6I88_RS11015	COG1380	Effector of murein hydrolase LrgA
I6I88_RS11020	COG1346	cytolysis
I6I88_RS11025	COG1289	transmembrane transporter activity
I6I88_RS11030	COG1022	Amp-dependent synthetase and ligase
I6I88_RS11040	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6I88_RS11055	COG1028	Short-chain dehydrogenase reductase Sdr
I6I88_RS11060	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6I88_RS11070	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
I6I88_RS11085	COG0861	Integral membrane protein TerC family
I6I88_RS11095	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I6I88_RS11115	COG0116	Belongs to the methyltransferase superfamily
I6I88_RS11140	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6I88_RS11145	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6I88_RS11185	COG1506	peptidase
I6I88_RS11185	COG0823	Involved in the tonB-independent uptake of proteins
I6I88_RS11200	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6I88_RS11205	COG1597	lipid kinase activity
I6I88_RS11230	COG1335	isochorismatase
I6I88_RS11320	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I6I88_RS11335	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6I88_RS11355	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6I88_RS11355	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6I88_RS11360	COG2356	endonuclease I
I6I88_RS11375	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6I88_RS11380	COG0823	Involved in the tonB-independent uptake of proteins
I6I88_RS11380	COG1506	peptidase
I6I88_RS11385	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6I88_RS11405	COG0514	ATP-dependent DNA helicase (RecQ)
I6I88_RS11410	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6I88_RS11420	COG1678	Uncharacterized ACR, COG1678
I6I88_RS11465	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I88_RS11520	COG0824	Thioesterase
I6I88_RS11525	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6I88_RS11530	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6I88_RS11535	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I6I88_RS11550	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6I88_RS11570	COG1396	sequence-specific DNA binding
I6I88_RS11580	COG0587	DNA-directed DNA polymerase activity
I6I88_RS11605	COG2365	Tyrosine phosphatase family
I6I88_RS11615	COG0415	Belongs to the DNA photolyase family
I6I88_RS11620	COG0471	metal ion transport
I6I88_RS11630	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6I88_RS11635	COG1053	succinate dehydrogenase
I6I88_RS11645	COG1595	DNA-templated transcription, initiation
I6I88_RS11670	COG0237	dephospho-CoA kinase activity
I6I88_RS11680	COG2204	response regulator
I6I88_RS11685	COG0802	atpase or kinase
I6I88_RS11730	COG4771	TonB-dependent receptor
I6I88_RS11735	COG3384	dioxygenase
I6I88_RS11775	COG0436	Aminotransferase
I6I88_RS11780	COG1333	cytochrome c biogenesis protein
I6I88_RS11780	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6I88_RS11790	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I88_RS11820	COG2226	methyltransferase
I6I88_RS11830	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6I88_RS12175	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6I88_RS12175	COG1388	LysM domain
I6I88_RS12335	COG2814	Major facilitator Superfamily
I6I88_RS12370	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6I88_RS12380	COG2814	Major facilitator Superfamily
I6I88_RS12385	COG0583	DNA-binding transcription factor activity
I6I88_RS12405	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6I88_RS12415	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I6I88_RS12435	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6I88_RS12445	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I6I88_RS12450	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6I88_RS12515	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
I6I88_RS12530	COG0742	ribosomal rna small subunit methyltransferase
I6I88_RS12550	COG0569	domain protein
I6I88_RS12555	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6I88_RS12580	COG0488	(ABC) transporter
I6I88_RS12620	COG1360	Flagellar Motor Protein
I6I88_RS12640	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I6I88_RS12675	COG1702	phosphate starvation-inducible protein PhoH
I6I88_RS12705	COG0813	purine-nucleoside phosphorylase activity
I6I88_RS12710	COG0564	pseudouridine synthase activity
I6I88_RS12750	COG2274	protein secretion by the type I secretion system
I6I88_RS12765	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6I88_RS12785	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6I88_RS12790	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I6I88_RS12800	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6I88_RS12860	COG0586	Pfam SNARE associated Golgi protein
I6I88_RS12880	COG2204	response regulator
I6I88_RS12890	COG4152	abc transporter atp-binding protein
I6I88_RS12895	COG0484	heat shock protein binding
I6I88_RS12900	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I6I88_RS12905	COG1090	epimerase
I6I88_RS12925	COG2885	chlorophyll binding
I6I88_RS12935	COG0326	Molecular chaperone. Has ATPase activity
I6I88_RS12990	COG0494	nUDIX hydrolase
I6I88_RS13010	COG0254	rRNA binding
I6I88_RS13020	COG2217	Heavy metal translocating P-type atpase
I6I88_RS13040	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6I88_RS13045	COG1132	(ABC) transporter
I6I88_RS13050	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I6I88_RS13055	COG0105	UTP biosynthetic process
I6I88_RS13090	COG1266	CAAX protease self-immunity
I6I88_RS13095	COG1393	Belongs to the ArsC family
I6I88_RS13130	COG4206	TonB-dependent receptor
I6I88_RS13130	COG1629	transport
I6I88_RS13165	COG0748	coenzyme F420 binding
I6I88_RS13185	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I6I88_RS13195	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6I88_RS13195	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6I88_RS13235	COG0477	Major facilitator Superfamily
I6I88_RS13250	COG1216	Glycosyl transferase, family 2
I6I88_RS13255	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6I88_RS13275	COG0339	signal peptide processing
I6I88_RS13280	COG0653	protein targeting
I6I88_RS13295	COG1136	(ABC) transporter
I6I88_RS13415	COG0101	tRNA pseudouridine synthase activity
I6I88_RS13420	COG1132	(ABC) transporter
I6I88_RS13435	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6I88_RS13440	COG3279	Response regulator of the LytR AlgR family
I6I88_RS13460	COG0497	DNA recombination
I6I88_RS13490	COG1528	Iron-storage protein
I6I88_RS13495	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6I88_RS13505	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6I88_RS13520	COG2378	regulation of single-species biofilm formation
I6I88_RS13525	COG0359	binds to the 23S rRNA
I6I88_RS13530	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6I88_RS13535	COG0360	Binds together with S18 to 16S ribosomal RNA
I6I88_RS13540	COG1395	domain, Protein
I6I88_RS13550	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6I88_RS13595	COG0492	ferredoxin-NADP+ reductase activity
I6I88_RS13605	COG0814	amino acid
I6I88_RS13610	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6I88_RS13620	COG0525	valine-tRNA ligase activity
I6I88_RS13635	COG4464	protein tyrosine phosphatase activity
I6I88_RS13670	COG1611	Belongs to the LOG family
I6I88_RS13680	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6I88_RS13735	COG1482	cell wall glycoprotein biosynthetic process
I6I88_RS13745	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I6I88_RS13760	COG0514	ATP-dependent DNA helicase (RecQ)
I6I88_RS13765	COG0517	IMP dehydrogenase activity
I6I88_RS13765	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I6I88_RS13770	COG0805	protein transport
I6I88_RS13775	COG1137	ATPase activity
I6I88_RS13815	COG0564	pseudouridine synthase activity
I6I88_RS13825	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6I88_RS13830	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I6I88_RS13840	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I6I88_RS13860	COG1690	Belongs to the RtcB family
I6I88_RS13865	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I6I88_RS13875	COG2264	protein methyltransferase activity
I6I88_RS13895	COG0019	diaminopimelate decarboxylase activity
I6I88_RS13900	COG0527	aspartate kinase activity
I6I88_RS13905	COG1132	(ABC) transporter
I6I88_RS13915	COG0038	chloride channel
I6I88_RS13920	COG0069	glutamate synthase activity
I6I88_RS13940	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6I88_RS13945	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6I88_RS13950	COG2814	Major facilitator Superfamily
I6I88_RS13955	COG0336	Belongs to the RNA methyltransferase TrmD family
I6I88_RS13960	COG0335	large ribosomal subunit rRNA binding
I6I88_RS13975	COG1131	(ABC) transporter
I6I88_RS13980	COG0659	secondary active sulfate transmembrane transporter activity
I6I88_RS14010	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
I6I88_RS14055	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6I88_RS14060	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I88_RS14065	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6I88_RS14105	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
I6I88_RS14115	COG1253	flavin adenine dinucleotide binding
I6I88_RS14120	COG0295	cytidine deaminase activity
I6I88_RS14135	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I6I88_RS14140	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6I88_RS14185	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6I88_RS14190	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
I6I88_RS14200	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6I88_RS14210	COG3958	Transketolase
I6I88_RS14215	COG3959	Transketolase, thiamine diphosphate binding domain
I6I88_RS14220	COG1120	ATPase activity
I6I88_RS14225	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I6I88_RS14230	COG1187	pseudouridine synthase activity
I6I88_RS14240	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6I88_RS14245	COG3853	Toxic anion resistance protein (TelA)
I6I88_RS14270	COG0697	spore germination
I6I88_RS14310	COG1114	Component of the transport system for branched-chain amino acids
I6I88_RS14315	COG0519	Catalyzes the synthesis of GMP from XMP
I6I88_RS14325	COG1858	cytochrome C peroxidase
I6I88_RS14370	COG3876	Protein conserved in bacteria
I6I88_RS14385	COG4206	TonB-dependent receptor
I6I88_RS14385	COG1629	transport
I6I88_RS14395	COG3279	Response regulator of the LytR AlgR family
I6I88_RS14420	COG0602	queuosine metabolic process
I6I88_RS14430	COG1217	gtp-binding protein TYPA
I6I88_RS14435	COG0268	Binds directly to 16S ribosomal RNA
I6I88_RS14470	COG0442	prolyl-tRNA aminoacylation
I6I88_RS14490	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6I88_RS14500	COG0584	glycerophosphoryl diester phosphodiesterase
I6I88_RS14535	COG0471	metal ion transport
I6I88_RS14545	COG2205	protein histidine kinase activity
I6I88_RS14560	COG0242	peptide deformylase activity
I6I88_RS14595	COG0339	signal peptide processing
I6I88_RS14605	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I88_RS14610	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6I88_RS14615	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I6I88_RS14625	COG4206	TonB-dependent receptor
I6I88_RS14645	COG0148	phosphopyruvate hydratase activity
I6I88_RS14650	COG0505	Belongs to the CarA family
I6I88_RS14655	COG0203	ribosomal protein L17
I6I88_RS14660	COG0202	RNA polymerase activity
I6I88_RS14665	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I6I88_RS14670	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I6I88_RS14675	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I6I88_RS14680	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6I88_RS14685	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I6I88_RS14695	COG0200	Binds to the 23S rRNA
I6I88_RS14700	COG1841	ribosomal large subunit assembly
I6I88_RS14705	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I6I88_RS14710	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I6I88_RS14715	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I6I88_RS14720	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I6I88_RS14725	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6I88_RS14730	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I6I88_RS14735	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I6I88_RS14740	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I6I88_RS14745	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I6I88_RS14750	COG0255	Belongs to the universal ribosomal protein uL29 family
I6I88_RS14755	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I6I88_RS14760	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I6I88_RS14765	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I6I88_RS14770	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I6I88_RS14775	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I6I88_RS14780	COG0089	rRNA binding
I6I88_RS14785	COG0088	Forms part of the polypeptide exit tunnel
I6I88_RS14790	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I6I88_RS14795	COG0051	transcription antitermination factor activity, RNA binding
I6I88_RS14800	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6I88_RS14805	COG0049	tRNA binding
I6I88_RS14810	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I6I88_RS14820	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6I88_RS14830	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6I88_RS14840	COG2003	Belongs to the UPF0758 family
I6I88_RS14850	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6I88_RS14860	COG3591	Belongs to the peptidase S1B family
I6I88_RS14865	COG1320	monovalent cation:proton antiporter activity
I6I88_RS14870	COG2212	antiporter activity
I6I88_RS14875	COG1863	multisubunit Na H antiporter MnhE subunit
I6I88_RS14880	COG0651	ATP synthesis coupled electron transport
I6I88_RS14885	COG1006	Multisubunit Na H antiporter MnhC subunit
I6I88_RS14890	COG2111	Na H antiporter
I6I88_RS14895	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6I88_RS14895	COG2111	Na H antiporter
I6I88_RS14900	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I6I88_RS14910	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I6I88_RS14915	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I6I88_RS14930	COG1858	cytochrome C peroxidase
I6I88_RS14945	COG1028	Short-chain dehydrogenase reductase Sdr
I6I88_RS14950	COG2234	aminopeptidase activity
I6I88_RS14960	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I6I88_RS14970	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I6I88_RS14975	COG0085	RNA polymerase activity
I6I88_RS14980	COG0222	ribosome binding
I6I88_RS14985	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I6I88_RS14990	COG0081	regulation of translation
I6I88_RS14995	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I6I88_RS15040	COG4974	Belongs to the 'phage' integrase family
I6I88_RS15045	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I6I88_RS15050	COG3279	Response regulator of the LytR AlgR family
I6I88_RS15055	COG3275	phosphorelay sensor kinase activity
I6I88_RS15075	COG1960	acyl-CoA dehydrogenase activity
I6I88_RS15105	COG4771	TonB-dependent receptor
I6I88_RS15115	COG1629	transport
I6I88_RS15115	COG4206	TonB-dependent receptor
I6I88_RS15130	COG1629	transport
I6I88_RS15130	COG4206	TonB-dependent receptor
I6I88_RS15135	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6I88_RS15140	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I6I88_RS15145	COG1705	Flagellar rod assembly protein muramidase FlgJ
I6I88_RS15145	COG3951	Flagellar rod assembly protein muramidase FlgJ
I6I88_RS15150	COG2515	1-aminocyclopropane-1-carboxylate deaminase
I6I88_RS15155	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
I6I88_RS15185	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6I88_RS15190	COG0739	heme binding
I6I88_RS15200	COG1704	LemA family
I6I88_RS15220	COG1160	GTP binding
I6I88_RS15225	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I6I88_RS15255	COG3321	synthase
I6I88_RS15255	COG0604	alcohol dehydrogenase
I6I88_RS15260	COG0657	acetylesterase activity
I6I88_RS15265	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6I88_RS15285	COG0488	(ABC) transporter
I6I88_RS15290	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I88_RS15290	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
I6I88_RS15325	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6I88_RS15350	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I6I88_RS15355	COG0459	protein refolding
I6I88_RS15360	COG0259	pyridoxamine-phosphate oxidase activity
I6I88_RS15365	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6I88_RS15370	COG0321	lipoyl(octanoyl) transferase activity
I6I88_RS15375	COG0401	homolog of Blt101
I6I88_RS15380	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I6I88_RS15395	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6I88_RS15415	COG1185	polyribonucleotide nucleotidyltransferase activity
I6I88_RS15420	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I6I88_RS15425	COG1956	GAF domain-containing protein
I6I88_RS15450	COG1610	YqeY-like protein
I6I88_RS15495	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6I88_RS15510	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6I88_RS15515	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6I88_RS15525	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I6I88_RS15530	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6I88_RS15535	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6I88_RS15540	COG0768	penicillin binding
I6I88_RS15550	COG0275	rRNA processing
I6I88_RS15555	COG2001	Belongs to the MraZ family
I6I88_RS15560	COG2267	carboxylic ester hydrolase activity
I6I88_RS15565	COG0218	Necessary for normal cell division and for the maintenance of normal septation
I6I88_RS15580	COG4771	TonB-dependent receptor
I6I88_RS15585	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I6I88_RS15600	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I6I88_RS15605	COG0463	Glycosyl transferase, family 2
I6I88_RS15620	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
I6I88_RS15625	COG2363	Small membrane protein
I6I88_RS15655	COG4172	Belongs to the ABC transporter superfamily
I6I88_RS15675	COG4122	O-methyltransferase activity
I6I88_RS15680	COG0671	phosphoesterase, PA-phosphatase related
I6I88_RS15685	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6I88_RS15695	COG3340	Belongs to the peptidase S51 family
I6I88_RS15740	COG1538	Outer membrane efflux protein
I6I88_RS15750	COG3118	belongs to the thioredoxin family
I6I88_RS15765	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6I88_RS15765	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6I88_RS15780	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I6I88_RS15785	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I6I88_RS15790	COG0052	Belongs to the universal ribosomal protein uS2 family
I6I88_RS15795	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I6I88_RS15800	COG1823	symporter activity
I6I88_RS15820	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
I6I88_RS15835	COG0352	thiamine-phosphate diphosphorylase activity
I6I88_RS15840	COG2022	thiamine diphosphate biosynthetic process
I6I88_RS15850	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6I88_RS15855	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
I6I88_RS15865	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6I88_RS15870	COG3852	Histidine kinase
I6I88_RS15880	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6I88_RS15910	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I6I88_RS15945	COG4771	TonB-dependent receptor
I6I88_RS15950	COG1970	mechanosensitive ion channel activity
I6I88_RS15955	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6I88_RS15985	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6I88_RS15985	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6I88_RS15995	COG0612	Peptidase, M16
I6I88_RS16005	COG0481	GTPase activity
I6I88_RS16030	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6I88_RS16035	COG1335	isochorismatase
I6I88_RS16040	COG0668	transmembrane transport
I6I88_RS16050	COG0823	Involved in the tonB-independent uptake of proteins
I6I88_RS16050	COG1506	peptidase
I6I88_RS16055	COG1301	dicarboxylic acid transport
I6I88_RS16060	COG0586	Pfam SNARE associated Golgi protein
I6I88_RS16065	COG0633	Ferredoxin
I6I88_RS16070	COG0492	ferredoxin-NADP+ reductase activity
I6I88_RS16080	COG0489	protein tyrosine kinase activity
I6I88_RS16125	COG0577	efflux transmembrane transporter activity
I6I88_RS16125	COG1136	(ABC) transporter
I6I88_RS16130	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I88_RS16135	COG2204	response regulator
I6I88_RS16140	COG4191	Histidine kinase
I6I88_RS16155	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I6I88_RS16160	COG5002	protein histidine kinase activity
I6I88_RS16165	COG0745	RESPONSE REGULATOR receiver
I6I88_RS16205	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I6I88_RS16255	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6I88_RS16260	COG0252	asparaginase activity
I6I88_RS16265	COG1027	Aspartate ammonia-lyase
I6I88_RS16270	COG0358	DNA primase activity
I6I88_RS16300	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I6I88_RS16305	COG1028	Short-chain dehydrogenase reductase Sdr
I6I88_RS16310	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6I88_RS16310	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6I88_RS16325	COG0113	porphobilinogen synthase activity
I6I88_RS16330	COG0408	coproporphyrinogen oxidase activity
I6I88_RS16340	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I6I88_RS16350	COG0181	hydroxymethylbilane synthase activity
I6I88_RS16355	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
I6I88_RS16365	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I6I88_RS16370	COG1981	membrane
I6I88_RS16380	COG1024	Enoyl-CoA hydratase
I6I88_RS16400	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I6I88_RS16435	COG0423	glycine-tRNA ligase activity
I6I88_RS16440	COG2353	YceI-like domain
I6I88_RS16450	COG1027	Aspartate ammonia-lyase
I6I88_RS16465	COG1040	competence protein
I6I88_RS16495	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6I88_RS16505	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6I88_RS16510	COG1053	succinate dehydrogenase
I6I88_RS16545	COG1074	ATP-dependent DNA helicase activity
I6I88_RS16555	COG0471	metal ion transport
I6I88_RS16590	COG0328	RNA-DNA hybrid ribonuclease activity
I6I88_RS16595	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6I88_RS16600	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6I88_RS16605	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6I88_RS16610	COG0571	ribonuclease III activity
I6I88_RS16620	COG0469	pyruvate kinase activity
I6I88_RS16625	COG1418	mRNA catabolic process
I6I88_RS16650	COG4774	siderophore transport
I6I88_RS16655	COG0792	nuclease activity
I6I88_RS16660	COG1619	proteins homologs of microcin C7 resistance protein MccF
I6I88_RS16665	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6I88_RS16680	COG2954	triphosphatase activity
I6I88_RS16700	COG1131	(ABC) transporter
I6I88_RS16750	COG4771	TonB-dependent receptor
I6I88_RS16765	COG2814	Major facilitator Superfamily
I6I88_RS16770	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I6I88_RS16780	COG0193	aminoacyl-tRNA hydrolase activity
I6I88_RS16785	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I6I88_RS16790	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6I88_RS16840	COG0492	ferredoxin-NADP+ reductase activity
I6I88_RS16840	COG3118	belongs to the thioredoxin family
I6I88_RS16860	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I6I88_RS16870	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6I88_RS16875	COG2239	Acts as a magnesium transporter
I6I88_RS16880	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6I88_RS16905	COG0708	Exodeoxyribonuclease III
I6I88_RS16910	COG2885	chlorophyll binding
I6I88_RS16915	COG0668	transmembrane transport
I6I88_RS16930	COG0756	dUTP diphosphatase activity
I6I88_RS16935	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6I88_RS16955	COG1012	belongs to the aldehyde dehydrogenase family
I6I88_RS16975	COG0714	Associated with various cellular activities
I6I88_RS16990	COG2304	oxidoreductase activity
I6I88_RS16995	COG2304	oxidoreductase activity
I6I88_RS17025	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I6I88_RS17065	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6I88_RS17085	COG0165	Argininosuccinate lyase
I6I88_RS17095	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6I88_RS17100	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6I88_RS17110	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I6I88_RS17130	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6I88_RS17135	COG0859	PFAM glycosyl transferase family 9
I6I88_RS17145	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I6I88_RS17160	COG0151	Belongs to the GarS family
I6I88_RS17235	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6I88_RS17250	COG0698	ribose 5-phosphate isomerase
I6I88_RS17255	COG0318	PFAM AMP-dependent synthetase and ligase
I6I88_RS17260	COG0557	exoribonuclease II activity
I6I88_RS17340	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
I6I88_RS17340	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6I88_RS17355	COG0644	oxidoreductase
I6I88_RS17375	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6I88_RS17410	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6I88_RS17415	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6I88_RS17440	COG1131	(ABC) transporter
I6I88_RS17465	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6I88_RS17480	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6I88_RS17485	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6I88_RS17490	COG1028	Short-chain dehydrogenase reductase Sdr
I6I88_RS17510	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I6I88_RS17515	COG0445	tRNA wobble uridine modification
I6I88_RS17520	COG2226	methyltransferase
I6I88_RS17530	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6I88_RS17535	COG0470	DNA polymerase III
I6I88_RS17540	COG0126	phosphoglycerate kinase activity
I6I88_RS17555	COG0594	ribonuclease P activity
I6I88_RS17570	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6I88_RS17575	COG0316	Belongs to the HesB IscA family
I6I88_RS17580	COG0719	Fe-S assembly protein
I6I88_RS17585	COG0396	ATPase activity
I6I88_RS17590	COG0719	Fe-S assembly protein
I6I88_RS17595	COG2197	response regulator
I6I88_RS17620	COG0542	response to heat
I6I88_RS17665	COG3501	Rhs element vgr protein
I6I88_RS17680	COG3209	COG3209 Rhs family protein
I6I88_RS17705	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6I88_RS17715	COG3720	iron ion transport
I6I88_RS17725	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I88_RS17735	COG0501	Belongs to the peptidase M48B family
I6I88_RS17740	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6I88_RS17745	COG2166	iron-sulfur cluster assembly
I6I88_RS17750	COG2151	metal-sulfur cluster biosynthetic enzyme
I6I88_RS17765	COG2502	aspartate--ammonia ligase
I6I88_RS17770	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6I88_RS17800	COG2885	chlorophyll binding
I6I88_RS17815	COG1607	acyl-coa hydrolase
I6I88_RS17825	COG0758	DNA mediated transformation
I6I88_RS17830	COG0180	Tryptophanyl-tRNA synthetase
I6I88_RS17840	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I6I88_RS17845	COG3158	transport of potassium into the cell
I6I88_RS17855	COG0826	peptidase U32
I6I88_RS17875	COG0194	GDP metabolic process
I6I88_RS17880	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I6I88_RS17910	COG1131	(ABC) transporter
I6I88_RS17935	COG0356	it plays a direct role in the translocation of protons across the membrane
I6I88_RS17940	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6I88_RS17945	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I6I88_RS17950	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6I88_RS17955	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I6I88_RS17960	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I6I88_RS17995	COG3179	chitinase
I6I88_RS18010	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6I88_RS18015	COG1774	PSP1 C-terminal conserved region
I6I88_RS18025	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I6I88_RS18030	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I6I88_RS18075	COG1381	Involved in DNA repair and RecF pathway recombination
I6I88_RS18080	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6I88_RS18090	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I6I88_RS18100	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6I88_RS18125	COG2207	Transcriptional regulator
I6I88_RS18125	COG4753	response regulator
I6I88_RS18135	COG0322	excinuclease ABC activity
I6I88_RS18140	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6I88_RS18150	COG3185	4-Hydroxyphenylpyruvate dioxygenase
I6I88_RS18170	COG0166	Belongs to the GPI family
I6I88_RS18205	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6I88_RS18205	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6I88_RS18235	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6I88_RS18250	COG0527	aspartate kinase activity
I6I88_RS18260	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
I6I88_RS18275	COG0793	Belongs to the peptidase S41A family
I6I88_RS18280	COG3590	peptidase
I6I88_RS18285	COG3590	peptidase
I6I88_RS18290	COG1999	signal sequence binding
I6I88_RS18325	COG1007	ATP synthesis coupled electron transport
I6I88_RS18335	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6I88_RS18340	COG0713	ATP synthesis coupled electron transport
I6I88_RS18345	COG0839	Belongs to the complex I subunit 6 family
I6I88_RS18350	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6I88_RS18355	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
I6I88_RS18360	COG1034	ATP synthesis coupled electron transport
I6I88_RS18365	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
I6I88_RS18370	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
I6I88_RS18375	COG0649	NAD binding
I6I88_RS18380	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6I88_RS18385	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6I88_RS18390	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6I88_RS18395	COG1278	Cold shock
I6I88_RS18400	COG0439	Biotin carboxylase
I6I88_RS18405	COG0511	ligase activity, forming carbon-carbon bonds
I6I88_RS18410	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6I88_RS18415	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I6I88_RS18425	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I6I88_RS18450	COG0589	response to stress
I6I88_RS18455	COG0779	Required for maturation of 30S ribosomal subunits
I6I88_RS18460	COG0195	Participates in both transcription termination and antitermination
I6I88_RS18460	COG2251	uridine kinase activity
I6I88_RS18465	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I6I88_RS18480	COG0196	riboflavin kinase activity
I6I88_RS18490	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6I88_RS18495	COG0720	synthase
I6I88_RS18535	COG2885	chlorophyll binding
I6I88_RS18580	COG4245	von Willebrand factor, type A
I6I88_RS18595	COG3853	Toxic anion resistance protein (TelA)
I6I88_RS18615	COG2310	stress, protein
I6I88_RS18620	COG2310	stress, protein
I6I88_RS18635	COG1435	thymidine kinase activity
I6I88_RS18645	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I6I88_RS18650	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6I88_RS18660	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6I88_RS18660	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
I6I88_RS18665	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6I88_RS18675	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6I88_RS18680	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6I88_RS18680	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6I88_RS18695	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6I88_RS18695	COG3153	acetyltransferase
I6I88_RS18705	COG0745	RESPONSE REGULATOR receiver
I6I88_RS18710	COG5002	protein histidine kinase activity
I6I88_RS18715	COG1285	pathogenesis
I6I88_RS18720	COG2239	Acts as a magnesium transporter
I6I88_RS18765	COG0612	Peptidase, M16
I6I88_RS18775	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6I88_RS18785	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6I88_RS18795	COG1012	belongs to the aldehyde dehydrogenase family
I6I88_RS18820	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I6I88_RS18825	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6I88_RS18835	COG0297	glycogen (starch) synthase activity
I6I88_RS18840	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I6I88_RS18845	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
I6I88_RS18860	COG2972	Histidine kinase
I6I88_RS18865	COG3279	Response regulator of the LytR AlgR family
I6I88_RS18875	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function