locus-tag	class	description
MPR_RS00020	COG0698	ribose 5-phosphate isomerase
MPR_RS00025	COG0318	PFAM AMP-dependent synthetase and ligase
MPR_RS00040	COG0557	exoribonuclease II activity
MPR_RS00095	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MPR_RS00095	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
MPR_RS00105	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
MPR_RS00110	COG0445	tRNA wobble uridine modification
MPR_RS00125	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MPR_RS00130	COG0470	DNA polymerase III
MPR_RS00135	COG0126	phosphoglycerate kinase activity
MPR_RS00140	COG3942	CHAP domain
MPR_RS00140	COG1388	LysM domain
MPR_RS00150	COG3158	transport of potassium into the cell
MPR_RS00155	COG2365	Tyrosine phosphatase family
MPR_RS00160	COG0594	ribonuclease P activity
MPR_RS00175	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MPR_RS00180	COG1943	Transposase
MPR_RS00185	COG0316	Belongs to the HesB IscA family
MPR_RS00190	COG0719	Fe-S assembly protein
MPR_RS00195	COG0396	ATPase activity
MPR_RS00200	COG0719	Fe-S assembly protein
MPR_RS00205	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MPR_RS00215	COG3720	iron ion transport
MPR_RS00220	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
MPR_RS00225	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MPR_RS00235	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MPR_RS00240	COG2166	iron-sulfur cluster assembly
MPR_RS00245	COG2151	metal-sulfur cluster biosynthetic enzyme
MPR_RS00260	COG2502	aspartate--ammonia ligase
MPR_RS00265	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MPR_RS00280	COG1607	acyl-coa hydrolase
MPR_RS00290	COG0758	DNA mediated transformation
MPR_RS00290	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
MPR_RS00295	COG0180	Tryptophanyl-tRNA synthetase
MPR_RS00315	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
MPR_RS00325	COG0242	peptide deformylase activity
MPR_RS00360	COG0826	peptidase U32
MPR_RS00375	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
MPR_RS00380	COG1561	YicC-like family, N-terminal region
MPR_RS00385	COG0194	GDP metabolic process
MPR_RS00390	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
MPR_RS00395	COG1979	alcohol dehydrogenase
MPR_RS00400	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
MPR_RS00425	COG4152	abc transporter atp-binding protein
MPR_RS00450	COG0356	it plays a direct role in the translocation of protons across the membrane
MPR_RS00455	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MPR_RS00460	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
MPR_RS00465	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MPR_RS00470	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
MPR_RS00475	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
MPR_RS00495	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
MPR_RS00500	COG1774	PSP1 C-terminal conserved region
MPR_RS00515	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
MPR_RS00565	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MPR_RS00565	COG3153	acetyltransferase
MPR_RS00575	COG0745	RESPONSE REGULATOR receiver
MPR_RS00580	COG5002	protein histidine kinase activity
MPR_RS00585	COG1285	pathogenesis
MPR_RS00590	COG2239	Acts as a magnesium transporter
MPR_RS00595	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MPR_RS00620	COG1629	transport
MPR_RS00620	COG4206	TonB-dependent receptor
MPR_RS00635	COG0612	Peptidase, M16
MPR_RS00640	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
MPR_RS00650	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MPR_RS00655	COG1012	belongs to the aldehyde dehydrogenase family
MPR_RS00685	COG0516	GMP reductase activity
MPR_RS00685	COG0517	IMP dehydrogenase activity
MPR_RS00695	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
MPR_RS00700	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
MPR_RS00705	COG0297	glycogen (starch) synthase activity
MPR_RS00715	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
MPR_RS00720	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
MPR_RS00725	COG0355	proton-transporting ATP synthase activity, rotational mechanism
MPR_RS00735	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
MPR_RS00755	COG2323	membrane
MPR_RS00760	COG3540	Alkaline phosphatase
MPR_RS00765	COG0501	Belongs to the peptidase M48B family
MPR_RS00785	COG1381	Involved in DNA repair and RecF pathway recombination
MPR_RS00790	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
MPR_RS00800	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
MPR_RS00805	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MPR_RS00810	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
MPR_RS00855	COG0322	excinuclease ABC activity
MPR_RS00860	COG1752	Esterase of the alpha-beta hydrolase superfamily
MPR_RS00870	COG3185	4-Hydroxyphenylpyruvate dioxygenase
MPR_RS00880	COG3483	tryptophan 2,3-dioxygenase activity
MPR_RS00885	COG0739	heme binding
MPR_RS00890	COG0166	Belongs to the GPI family
MPR_RS00895	COG1629	transport
MPR_RS00900	COG0667	Aldo Keto reductase
MPR_RS00905	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MPR_RS00905	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MPR_RS00940	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MPR_RS00980	COG0527	aspartate kinase activity
MPR_RS00990	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
MPR_RS01005	COG0793	Belongs to the peptidase S41A family
MPR_RS01010	COG3590	peptidase
MPR_RS01015	COG1999	signal sequence binding
MPR_RS01020	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
MPR_RS01020	COG1918	ferrous iron import across plasma membrane
MPR_RS01030	COG0159	tryptophan synthase activity
MPR_RS01035	COG0133	tryptophan synthase activity
MPR_RS01040	COG0135	phosphoribosylanthranilate isomerase activity
MPR_RS01045	COG0134	indole-3-glycerol-phosphate synthase activity
MPR_RS01050	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MPR_RS01055	COG0512	Glutamine amidotransferase of anthranilate synthase
MPR_RS01060	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MPR_RS01065	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MPR_RS01075	COG1007	ATP synthesis coupled electron transport
MPR_RS01085	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MPR_RS01090	COG0713	ATP synthesis coupled electron transport
MPR_RS01095	COG0839	Belongs to the complex I subunit 6 family
MPR_RS01100	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MPR_RS01105	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
MPR_RS01110	COG1034	ATP synthesis coupled electron transport
MPR_RS01115	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
MPR_RS01120	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
MPR_RS01125	COG0649	NAD binding
MPR_RS01130	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MPR_RS01135	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MPR_RS01140	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MPR_RS01145	COG1278	Cold shock
MPR_RS01150	COG0439	Biotin carboxylase
MPR_RS01155	COG0511	ligase activity, forming carbon-carbon bonds
MPR_RS01160	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MPR_RS01165	COG0333	Belongs to the bacterial ribosomal protein bL32 family
MPR_RS01175	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
MPR_RS01205	COG0589	response to stress
MPR_RS01210	COG0779	Required for maturation of 30S ribosomal subunits
MPR_RS01215	COG0195	Participates in both transcription termination and antitermination
MPR_RS01220	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
MPR_RS01225	COG2738	Putative neutral zinc metallopeptidase
MPR_RS01235	COG0196	riboflavin kinase activity
MPR_RS01245	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MPR_RS01250	COG0720	synthase
MPR_RS01300	COG2814	Major facilitator Superfamily
MPR_RS01305	COG1435	thymidine kinase activity
MPR_RS01315	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
MPR_RS01325	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
MPR_RS01325	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
MPR_RS01330	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
MPR_RS01340	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MPR_RS01340	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MPR_RS01365	COG0252	asparaginase activity
MPR_RS01375	COG0084	hydrolase, TatD family'
MPR_RS01405	COG2194	sulfuric ester hydrolase activity
MPR_RS01415	COG0814	amino acid
MPR_RS01440	COG1505	serine-type exopeptidase activity
MPR_RS01445	COG1028	Short-chain dehydrogenase reductase Sdr
MPR_RS01455	COG0783	Belongs to the Dps family
MPR_RS01465	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MPR_RS01470	COG0300	oxidoreductase activity
MPR_RS01480	COG1960	acyl-CoA dehydrogenase activity
MPR_RS01495	COG1051	belongs to the nudix hydrolase family
MPR_RS01505	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
MPR_RS01520	COG0527	aspartate kinase activity
MPR_RS01520	COG0460	homoserine dehydrogenase
MPR_RS01525	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MPR_RS01530	COG0626	cystathionine gamma-synthase activity
MPR_RS01540	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
MPR_RS01565	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
MPR_RS01570	COG0228	four-way junction DNA binding
MPR_RS01705	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MPR_RS01710	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
MPR_RS01810	COG2169	Transcriptional regulator
MPR_RS01830	COG1196	nuclear chromosome segregation
MPR_RS01830	COG3264	Mechanosensitive ion channel
MPR_RS01835	COG3757	hydrolase, family 25
MPR_RS01840	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MPR_RS01850	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
MPR_RS01860	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MPR_RS01865	COG0791	NLP P60 protein
MPR_RS01870	COG0658	competence protein
MPR_RS01870	COG2333	competence protein COMEC
MPR_RS01885	COG3104	oligopeptide transport
MPR_RS01910	COG1506	peptidase
MPR_RS01910	COG0823	Involved in the tonB-independent uptake of proteins
MPR_RS01970	COG2081	HI0933 family
MPR_RS02060	COG1187	pseudouridine synthase activity
MPR_RS02065	COG1741	Belongs to the pirin family
MPR_RS02070	COG0427	acetyl-CoA hydrolase
MPR_RS02090	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MPR_RS02105	COG1012	belongs to the aldehyde dehydrogenase family
MPR_RS02120	COG0357	Ribosomal RNA small subunit methyltransferase G
MPR_RS02125	COG0436	Aminotransferase
MPR_RS02135	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
MPR_RS02145	COG2989	Protein conserved in bacteria
MPR_RS02150	COG4771	TonB-dependent receptor
MPR_RS02160	COG4221	oxidoreductase activity
MPR_RS02175	COG0754	glutathionylspermidine amidase activity
MPR_RS02245	COG0346	lactoylglutathione lyase activity
MPR_RS02250	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
MPR_RS02265	COG0326	Molecular chaperone. Has ATPase activity
MPR_RS02285	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MPR_RS02300	COG1395	domain, Protein
MPR_RS02305	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MPR_RS02330	COG1309	transcriptional regulator
MPR_RS02355	COG0567	Dehydrogenase, E1 component
MPR_RS02360	COG0508	dehydrogenase complex catalyzes the overall conversion of
MPR_RS02365	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MPR_RS02370	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
MPR_RS02370	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MPR_RS02385	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MPR_RS02390	COG0232	Belongs to the dGTPase family. Type 2 subfamily
MPR_RS02400	COG0211	Belongs to the bacterial ribosomal protein bL27 family
MPR_RS02405	COG0261	This protein binds to 23S rRNA in the presence of protein L20
MPR_RS02410	COG0612	Peptidase, M16
MPR_RS02415	COG0612	Peptidase, M16
MPR_RS02440	COG0629	single-stranded DNA binding
MPR_RS02445	COG1194	a g-specific adenine glycosylase
MPR_RS02450	COG0776	regulation of translation
MPR_RS02455	COG1530	ribonuclease E activity
MPR_RS02460	COG4953	penicillin-binding protein 1C
MPR_RS02465	COG2373	Large extracellular alpha-helical protein
MPR_RS02475	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
MPR_RS02495	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
MPR_RS02500	COG0017	Asparaginyl-tRNA synthetase
MPR_RS02510	COG0233	cytoplasmic translational termination
MPR_RS02515	COG0528	UMP kinase activity
MPR_RS02565	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
MPR_RS02570	COG1968	undecaprenyl-diphosphatase activity
MPR_RS02580	COG2177	Part of the ABC transporter FtsEX involved in
MPR_RS02585	COG0495	leucyl-tRNA aminoacylation
MPR_RS02595	COG2010	Cytochrome c
MPR_RS02600	COG0437	4 iron, 4 sulfur cluster binding
MPR_RS02625	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
MPR_RS02630	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
MPR_RS02635	COG2255	four-way junction helicase activity
MPR_RS02640	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
MPR_RS02645	COG0281	malic enzyme
MPR_RS02645	COG0280	phosphate acetyltransferase
MPR_RS02650	COG0632	four-way junction helicase activity
MPR_RS02660	COG0509	glycine decarboxylation via glycine cleavage system
MPR_RS02670	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
MPR_RS02675	COG0109	protoheme IX farnesyltransferase activity
MPR_RS02700	COG1999	signal sequence binding
MPR_RS02705	COG2322	membrane
MPR_RS02720	COG1566	PFAM secretion protein HlyD family protein
MPR_RS02725	COG1214	PFAM Peptidase M22, glycoprotease
MPR_RS02730	COG0668	transmembrane transport
MPR_RS02735	COG1331	Highly conserved protein containing a thioredoxin domain
MPR_RS02760	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
MPR_RS02765	COG0596	Alpha beta hydrolase
MPR_RS02770	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
MPR_RS02780	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
MPR_RS02790	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MPR_RS02810	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
MPR_RS02825	COG1950	PFAM Membrane protein of
MPR_RS02840	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
MPR_RS02870	COG1917	Cupin 2, conserved barrel domain protein
MPR_RS02870	COG4977	sequence-specific DNA binding
MPR_RS02920	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
MPR_RS02955	COG2353	YceI-like domain
MPR_RS02970	COG1428	Deoxynucleoside kinase
MPR_RS02975	COG0616	signal peptide processing
MPR_RS03000	COG4717	serine-type aminopeptidase activity
MPR_RS03015	COG2814	Major facilitator Superfamily
MPR_RS03020	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
MPR_RS03025	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MPR_RS03045	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
MPR_RS03075	COG0772	Belongs to the SEDS family
MPR_RS03080	COG0768	penicillin binding
MPR_RS03095	COG1077	Cell shape determining protein MreB Mrl
MPR_RS03100	COG0138	bifunctional purine biosynthesis protein purh
MPR_RS03105	COG1136	(ABC) transporter
MPR_RS03105	COG0577	efflux transmembrane transporter activity
MPR_RS03110	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
MPR_RS03115	COG0191	fructose-bisphosphate aldolase activity
MPR_RS03135	COG2226	methyltransferase
MPR_RS03145	COG1115	amino acid carrier protein
MPR_RS03155	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
MPR_RS03165	COG0508	dehydrogenase complex catalyzes the overall conversion of
MPR_RS03165	COG0022	dehydrogenase e1 component
MPR_RS03180	COG2086	electron transfer activity
MPR_RS03185	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
MPR_RS03195	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
MPR_RS03205	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
MPR_RS03215	COG1428	Deoxynucleoside kinase
MPR_RS03220	COG1522	sequence-specific DNA binding
MPR_RS03225	COG1629	transport
MPR_RS03245	COG0730	response to heat
MPR_RS03250	COG2877	3-deoxy-8-phosphooctulonate synthase activity
MPR_RS03255	COG1162	GTPase activity
MPR_RS03265	COG0612	Peptidase, M16
MPR_RS03280	COG4206	TonB-dependent receptor
MPR_RS03280	COG1629	transport
MPR_RS03305	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
MPR_RS03310	COG1490	D-aminoacyl-tRNA deacylase activity
MPR_RS03325	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
MPR_RS03330	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
MPR_RS03335	COG3844	kynureninase activity
MPR_RS03340	COG0010	Belongs to the arginase family
MPR_RS03345	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MPR_RS03350	COG0433	COG0433 Predicted ATPase
MPR_RS03355	COG0811	peptide transport
MPR_RS03390	COG0602	queuosine metabolic process
MPR_RS03400	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MPR_RS03415	COG3279	Response regulator of the LytR AlgR family
MPR_RS03420	COG0702	epimerase
MPR_RS03425	COG4771	TonB-dependent receptor
MPR_RS03435	COG2972	Histidine kinase
MPR_RS03440	COG3876	Protein conserved in bacteria
MPR_RS03445	COG0577	efflux transmembrane transporter activity
MPR_RS03460	COG1733	regulation of RNA biosynthetic process
MPR_RS03465	COG2814	Major facilitator Superfamily
MPR_RS03475	COG1917	Cupin 2, conserved barrel domain protein
MPR_RS03475	COG2169	Transcriptional regulator
MPR_RS03525	COG0545	Peptidyl-prolyl cis-trans isomerase
MPR_RS03530	COG4753	response regulator
MPR_RS03530	COG2207	Transcriptional regulator
MPR_RS03540	COG0519	Catalyzes the synthesis of GMP from XMP
MPR_RS03545	COG1114	Component of the transport system for branched-chain amino acids
MPR_RS03550	COG5212	phosphodiesterase
MPR_RS03560	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MPR_RS03610	COG2217	Heavy metal translocating P-type atpase
MPR_RS03620	COG3047	cAMP biosynthetic process
MPR_RS03630	COG4145	pantothenate transmembrane transporter activity
MPR_RS03635	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
MPR_RS03645	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
MPR_RS03655	COG2949	membrane
MPR_RS03660	COG0513	Belongs to the DEAD box helicase family
MPR_RS03675	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
MPR_RS03675	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
MPR_RS03680	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
MPR_RS03680	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
MPR_RS03690	COG0572	uridine kinase
MPR_RS03705	COG0527	aspartate kinase activity
MPR_RS03710	COG0019	diaminopimelate decarboxylase activity
MPR_RS03730	COG2264	protein methyltransferase activity
MPR_RS03740	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
MPR_RS03745	COG1690	Belongs to the RtcB family
MPR_RS03760	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
MPR_RS03770	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
MPR_RS03775	COG1181	Belongs to the D-alanine--D-alanine ligase family
MPR_RS03785	COG0564	pseudouridine synthase activity
MPR_RS03790	COG0037	tRNA processing
MPR_RS03820	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MPR_RS03825	COG1132	(ABC) transporter
MPR_RS03830	COG0101	tRNA pseudouridine synthase activity
MPR_RS03880	COG1136	(ABC) transporter
MPR_RS03885	COG2096	Adenosyltransferase
MPR_RS03895	COG0653	protein targeting
MPR_RS03900	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
MPR_RS03910	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
MPR_RS03915	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MPR_RS03920	COG2217	Heavy metal translocating P-type atpase
MPR_RS03930	COG3278	Belongs to the heme-copper respiratory oxidase family
MPR_RS03945	COG0348	domain, Protein
MPR_RS03965	COG0681	Belongs to the peptidase S26 family
MPR_RS03970	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
MPR_RS03980	COG1475	DNA binding
MPR_RS03985	COG1192	Involved in chromosome partitioning
MPR_RS03990	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
MPR_RS04020	COG0662	Cupin 2, conserved barrel domain protein
MPR_RS04020	COG2207	Transcriptional regulator
MPR_RS04025	COG0456	acetyltransferase
MPR_RS04060	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MPR_RS04065	COG0183	Belongs to the thiolase family
MPR_RS04110	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
MPR_RS04120	COG0326	Molecular chaperone. Has ATPase activity
MPR_RS04130	COG2885	chlorophyll binding
MPR_RS04150	COG1090	epimerase
MPR_RS04155	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
MPR_RS04160	COG0484	heat shock protein binding
MPR_RS04165	COG4152	abc transporter atp-binding protein
MPR_RS04175	COG2204	response regulator
MPR_RS04200	COG2249	NAD(P)H dehydrogenase (quinone) activity
MPR_RS04215	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MPR_RS04220	COG1678	Uncharacterized ACR, COG1678
MPR_RS04230	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
MPR_RS04235	COG0514	ATP-dependent DNA helicase (RecQ)
MPR_RS04255	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
MPR_RS04265	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
MPR_RS04275	COG4974	Belongs to the 'phage' integrase family
MPR_RS04280	COG1418	mRNA catabolic process
MPR_RS04315	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
MPR_RS04320	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
MPR_RS04335	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
MPR_RS04350	COG1335	isochorismatase
MPR_RS04385	COG0659	secondary active sulfate transmembrane transporter activity
MPR_RS04390	COG1131	(ABC) transporter
MPR_RS04400	COG0335	large ribosomal subunit rRNA binding
MPR_RS04405	COG0336	Belongs to the RNA methyltransferase TrmD family
MPR_RS04415	COG2814	Major facilitator Superfamily
MPR_RS04420	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
MPR_RS04425	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
MPR_RS04430	COG0697	spore germination
MPR_RS04435	COG0069	glutamate synthase activity
MPR_RS04440	COG0038	chloride channel
MPR_RS04450	COG1132	(ABC) transporter
MPR_RS04455	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MPR_RS04465	COG1862	Preprotein translocase
MPR_RS04470	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MPR_RS04475	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
MPR_RS04480	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
MPR_RS04485	COG0488	(ABC) transporter
MPR_RS04495	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MPR_RS04520	COG2326	polyphosphate kinase activity
MPR_RS04535	COG0534	Mate efflux family protein
MPR_RS04545	COG1703	isobutyryl-CoA mutase activity
MPR_RS04550	COG2223	nitrite transmembrane transporter activity
MPR_RS04560	COG2239	Acts as a magnesium transporter
MPR_RS04580	COG0230	Belongs to the bacterial ribosomal protein bL34 family
MPR_RS04590	COG0473	3-isopropylmalate dehydrogenase activity
MPR_RS04595	COG0066	3-isopropylmalate dehydratase activity
MPR_RS04600	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
MPR_RS04605	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MPR_RS04640	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
MPR_RS04650	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
MPR_RS04655	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MPR_RS04665	COG4771	TonB-dependent receptor
MPR_RS04715	COG4682	membrane
MPR_RS04725	COG0577	efflux transmembrane transporter activity
MPR_RS04730	COG0124	histidyl-tRNA synthetase
MPR_RS04745	COG0753	catalase activity
MPR_RS04765	COG2733	membrane
MPR_RS04770	COG0564	pseudouridine synthase activity
MPR_RS04795	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MPR_RS04800	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
MPR_RS04870	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
MPR_RS04880	COG1663	tetraacyldisaccharide 4'-kinase activity
MPR_RS04885	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
MPR_RS04900	COG1187	pseudouridine synthase activity
MPR_RS04940	COG1506	peptidase
MPR_RS04945	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MPR_RS04955	COG2356	endonuclease I
MPR_RS04965	COG0586	Pfam SNARE associated Golgi protein
MPR_RS04970	COG2356	endonuclease I
MPR_RS04975	COG2356	endonuclease I
MPR_RS04980	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MPR_RS04980	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MPR_RS04995	COG1595	DNA-templated transcription, initiation
MPR_RS05000	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MPR_RS05025	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
MPR_RS05035	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MPR_RS05070	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MPR_RS05075	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
MPR_RS05085	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
MPR_RS05100	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MPR_RS05105	COG0606	chelatase, subunit chli
MPR_RS05115	COG2321	neutral zinc metallopeptidase
MPR_RS05120	COG4774	siderophore transport
MPR_RS05125	COG2207	Transcriptional regulator
MPR_RS05130	COG0217	transcriptional regulatory protein
MPR_RS05135	COG0404	The glycine cleavage system catalyzes the degradation of glycine
MPR_RS05145	COG2217	Heavy metal translocating P-type atpase
MPR_RS05160	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
MPR_RS05170	COG0564	pseudouridine synthase activity
MPR_RS05175	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
MPR_RS05185	COG1760	l-serine dehydratase
MPR_RS05190	COG0443	Heat shock 70 kDa protein
MPR_RS05215	COG0431	NADPH-dependent FMN reductase
MPR_RS05240	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
MPR_RS05245	COG1193	negative regulation of DNA recombination
MPR_RS05250	COG3153	acetyltransferase
MPR_RS05295	COG2204	response regulator
MPR_RS05305	COG0318	PFAM AMP-dependent synthetase and ligase
MPR_RS05310	COG0823	Involved in the tonB-independent uptake of proteins
MPR_RS05310	COG1506	peptidase
MPR_RS05325	COG0673	inositol 2-dehydrogenase activity
MPR_RS05340	COG0116	Belongs to the methyltransferase superfamily
MPR_RS05340	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
MPR_RS05405	COG0405	Gamma-glutamyltransferase
MPR_RS05420	COG1289	transmembrane transporter activity
MPR_RS05470	COG0339	signal peptide processing
MPR_RS05510	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
MPR_RS05515	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
MPR_RS05525	COG0288	reversible hydration of carbon dioxide
MPR_RS05535	COG0189	ligase activity
MPR_RS05535	COG4067	protein conserved in archaea
MPR_RS05540	COG0542	response to heat
MPR_RS05545	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MPR_RS05560	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
MPR_RS05570	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MPR_RS05580	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
MPR_RS05590	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MPR_RS05615	COG2207	Transcriptional regulator
MPR_RS05630	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MPR_RS05635	COG1120	ATPase activity
MPR_RS05640	COG0477	Major facilitator Superfamily
MPR_RS05645	COG4804	nuclease activity
MPR_RS05660	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MPR_RS05665	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
MPR_RS05670	COG0714	Associated with various cellular activities
MPR_RS05700	COG2860	membrane
MPR_RS05715	COG0424	maF-like protein
MPR_RS05720	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
MPR_RS05730	COG2346	COG2346, Truncated hemoglobins
MPR_RS05755	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
MPR_RS05785	COG1368	sulfuric ester hydrolase activity
MPR_RS05790	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
MPR_RS05805	COG2814	Major facilitator Superfamily
MPR_RS05810	COG0583	DNA-binding transcription factor activity
MPR_RS05815	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MPR_RS05820	COG4605	iron ion homeostasis
MPR_RS05825	COG4604	ABC transporter, ATP-binding protein
MPR_RS05830	COG4607	ABC-type enterochelin transport system periplasmic component
MPR_RS05835	COG1607	acyl-coa hydrolase
MPR_RS05860	COG0022	dehydrogenase e1 component
MPR_RS05865	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
MPR_RS05875	COG0022	dehydrogenase e1 component
MPR_RS05880	COG0156	8-amino-7-oxononanoate synthase activity
MPR_RS05885	COG2814	Major facilitator Superfamily
MPR_RS05900	COG1363	Peptidase, m42
MPR_RS05910	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
MPR_RS05920	COG2996	Protein conserved in bacteria
MPR_RS05935	COG4771	TonB-dependent receptor
MPR_RS05940	COG0642	Histidine kinase
MPR_RS05945	COG0745	RESPONSE REGULATOR receiver
MPR_RS05960	COG3275	phosphorelay sensor kinase activity
MPR_RS05965	COG3279	Response regulator of the LytR AlgR family
MPR_RS05970	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MPR_RS06020	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MPR_RS06050	COG2169	Transcriptional regulator
MPR_RS06095	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MPR_RS06100	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
MPR_RS06105	COG0291	Belongs to the bacterial ribosomal protein bL35 family
MPR_RS06110	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
MPR_RS06120	COG2884	Cell division ATP-binding protein ftsE
MPR_RS06130	COG1346	cytolysis
MPR_RS06150	COG0187	DNA topoisomerase II activity
MPR_RS06160	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MPR_RS06175	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
MPR_RS06180	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
MPR_RS06185	COG0215	cysteine-tRNA ligase activity
MPR_RS06190	COG0302	gtp cyclohydrolase
MPR_RS06245	COG2059	Chromate
MPR_RS06290	COG2169	Transcriptional regulator
MPR_RS06325	COG0688	phosphatidylethanolamine metabolic process
MPR_RS06330	COG3425	synthase
MPR_RS06335	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
MPR_RS06400	COG2197	response regulator
MPR_RS06415	COG4946	Tricorn protease homolog
MPR_RS06415	COG0823	Involved in the tonB-independent uptake of proteins
MPR_RS06415	COG1506	peptidase
MPR_RS06425	COG1629	transport
MPR_RS06475	COG2003	Belongs to the UPF0758 family
MPR_RS06635	COG0758	DNA mediated transformation
MPR_RS06635	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
MPR_RS06695	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
MPR_RS06720	COG0537	adenosine 5'-monophosphoramidase activity
MPR_RS06740	COG1309	transcriptional regulator
MPR_RS06805	COG4974	Belongs to the 'phage' integrase family
MPR_RS06810	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
MPR_RS06825	COG1024	Enoyl-CoA hydratase
MPR_RS06825	COG1250	3-hydroxyacyl-CoA dehydrogenase
MPR_RS06850	COG3279	Response regulator of the LytR AlgR family
MPR_RS06885	COG0628	permease
MPR_RS06890	COG1385	rRNA (uridine-N3-)-methyltransferase activity
MPR_RS06895	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
MPR_RS06905	COG0205	6-phosphofructokinase activity
MPR_RS06930	COG0251	oxidation-reduction process
MPR_RS06940	COG0860	N-Acetylmuramoyl-L-alanine amidase
MPR_RS06945	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
MPR_RS06955	COG0247	lactate metabolic process
MPR_RS06955	COG2181	nitrate reductase activity
MPR_RS06965	COG1472	Belongs to the glycosyl hydrolase 3 family
MPR_RS06970	COG4771	TonB-dependent receptor
MPR_RS07005	COG2249	NAD(P)H dehydrogenase (quinone) activity
MPR_RS07010	COG3118	belongs to the thioredoxin family
MPR_RS07020	COG2207	Transcriptional regulator
MPR_RS07055	COG1733	regulation of RNA biosynthetic process
MPR_RS07085	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MPR_RS07105	COG2195	Cleaves the N-terminal amino acid of tripeptides
MPR_RS07120	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
MPR_RS07125	COG0284	orotidine-5'-phosphate decarboxylase activity
MPR_RS07130	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MPR_RS07145	COG0210	DNA helicase
MPR_RS07150	COG0009	L-threonylcarbamoyladenylate synthase
MPR_RS07155	COG0045	succinate-CoA ligase (ADP-forming) activity
MPR_RS07160	COG4807	Protein conserved in bacteria
MPR_RS07165	COG0556	nucleotide-excision repair
MPR_RS07175	COG0494	nUDIX hydrolase
MPR_RS07180	COG2814	Major facilitator Superfamily
MPR_RS07190	COG1960	acyl-CoA dehydrogenase activity
MPR_RS07195	COG0183	Belongs to the thiolase family
MPR_RS07200	COG1250	3-hydroxyacyl-CoA dehydrogenase
MPR_RS07200	COG1024	Enoyl-CoA hydratase
MPR_RS07210	COG1022	Amp-dependent synthetase and ligase
MPR_RS07215	COG1368	sulfuric ester hydrolase activity
MPR_RS07240	COG0484	heat shock protein binding
MPR_RS07250	COG0542	response to heat
MPR_RS07315	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
MPR_RS07325	COG1012	belongs to the aldehyde dehydrogenase family
MPR_RS07340	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MPR_RS07360	COG1253	flavin adenine dinucleotide binding
MPR_RS07370	COG0460	homoserine dehydrogenase
MPR_RS07370	COG0527	aspartate kinase activity
MPR_RS07375	COG0083	homoserine kinase activity
MPR_RS07380	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
MPR_RS07385	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
MPR_RS07405	COG2819	hydrolase of the alpha beta superfamily
MPR_RS07430	COG0288	reversible hydration of carbon dioxide
MPR_RS07515	COG1104	cysteine desulfurase activity
MPR_RS07520	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
MPR_RS07525	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
MPR_RS07530	COG0579	oxidoreductase
MPR_RS07540	COG4585	Histidine kinase
MPR_RS07545	COG4452	Inner membrane protein CreD
MPR_RS07565	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
MPR_RS07565	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
MPR_RS07565	COG1703	isobutyryl-CoA mutase activity
MPR_RS07575	COG3011	Protein conserved in bacteria
MPR_RS07580	COG1193	negative regulation of DNA recombination
MPR_RS07595	COG0427	acetyl-CoA hydrolase
MPR_RS07605	COG0321	lipoyl(octanoyl) transferase activity
MPR_RS07605	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
MPR_RS07640	COG0513	Belongs to the DEAD box helicase family
MPR_RS07655	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
MPR_RS07660	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
MPR_RS07690	COG2204	response regulator
MPR_RS07700	COG0237	dephospho-CoA kinase activity
MPR_RS07735	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MPR_RS07740	COG2363	Small membrane protein
MPR_RS07755	COG0427	acetyl-CoA hydrolase
MPR_RS07760	COG0813	purine-nucleoside phosphorylase activity
MPR_RS07765	COG0023	Translation Initiation Factor
MPR_RS07780	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
MPR_RS07790	COG1702	phosphate starvation-inducible protein PhoH
MPR_RS07830	COG3279	Response regulator of the LytR AlgR family
MPR_RS07835	COG0475	glutathione-regulated potassium exporter activity
MPR_RS07860	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
MPR_RS07900	COG3645	SOS response
MPR_RS07910	COG0488	(ABC) transporter
MPR_RS07935	COG0833	amino acid
MPR_RS07945	COG0504	CTP synthase activity
MPR_RS07950	COG0706	membrane insertase activity
MPR_RS07955	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MPR_RS07960	COG0482	sulfurtransferase activity
MPR_RS07970	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MPR_RS07980	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MPR_RS07985	COG1054	Belongs to the UPF0176 family
MPR_RS08005	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
MPR_RS08015	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MPR_RS08075	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
MPR_RS08095	COG1204	response to ionizing radiation
MPR_RS08130	COG3278	Belongs to the heme-copper respiratory oxidase family
MPR_RS08150	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MPR_RS08155	COG0596	Alpha beta hydrolase
MPR_RS08160	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
MPR_RS08165	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MPR_RS08185	COG1794	racemase activity, acting on amino acids and derivatives
MPR_RS08205	COG0456	acetyltransferase
MPR_RS08210	COG3275	phosphorelay sensor kinase activity
MPR_RS08240	COG2207	Transcriptional regulator
MPR_RS08245	COG1629	transport
MPR_RS08245	COG4206	TonB-dependent receptor
MPR_RS08250	COG0702	epimerase
MPR_RS08255	COG1785	Belongs to the alkaline phosphatase family
MPR_RS08280	COG0006	proline dipeptidase activity
MPR_RS08295	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
MPR_RS08300	COG5002	protein histidine kinase activity
MPR_RS08305	COG0745	RESPONSE REGULATOR receiver
MPR_RS08310	COG0010	Belongs to the arginase family
MPR_RS08315	COG1228	amidohydrolase
MPR_RS08320	COG0598	Magnesium transport protein CorA
MPR_RS08325	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MPR_RS08355	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MPR_RS08360	COG3457	Alanine racemase
MPR_RS08375	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
MPR_RS08390	COG1522	sequence-specific DNA binding
MPR_RS08440	COG2814	Major facilitator Superfamily
MPR_RS08455	COG2885	chlorophyll binding
MPR_RS08480	COG1858	cytochrome C peroxidase
MPR_RS08490	COG3022	response to hydroperoxide
MPR_RS08495	COG2986	histidine ammonia-lyase
MPR_RS08500	COG1078	dGTPase activity
MPR_RS08505	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MPR_RS08510	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
MPR_RS08510	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
MPR_RS08515	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MPR_RS08520	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
MPR_RS08525	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MPR_RS08560	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
MPR_RS08590	COG0488	(ABC) transporter
MPR_RS08615	COG2234	aminopeptidase activity
MPR_RS08620	COG0300	oxidoreductase activity
MPR_RS08625	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
MPR_RS08650	COG0484	heat shock protein binding
MPR_RS08705	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
MPR_RS08715	COG0823	Involved in the tonB-independent uptake of proteins
MPR_RS08715	COG1506	peptidase
MPR_RS08720	COG1028	Short-chain dehydrogenase reductase Sdr
MPR_RS08760	COG2814	Major facilitator Superfamily
MPR_RS08790	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
MPR_RS08810	COG2197	response regulator
MPR_RS08840	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
MPR_RS08860	COG0012	GTP binding
MPR_RS08865	COG1295	ribonuclease BN
MPR_RS08885	COG0697	spore germination
MPR_RS08890	COG2169	Transcriptional regulator
MPR_RS08895	COG4948	Mandelate Racemase Muconate Lactonizing
MPR_RS08900	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
MPR_RS08905	COG1575	Belongs to the MenA family. Type 1 subfamily
MPR_RS08940	COG3384	dioxygenase
MPR_RS08945	COG0569	domain protein
MPR_RS08950	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MPR_RS08965	COG2818	Glycosylase
MPR_RS08985	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MPR_RS09005	COG4977	sequence-specific DNA binding
MPR_RS09005	COG1917	Cupin 2, conserved barrel domain protein
MPR_RS09040	COG1335	isochorismatase
MPR_RS09070	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
MPR_RS09075	COG1169	isochorismate synthase
MPR_RS09085	COG0009	L-threonylcarbamoyladenylate synthase
MPR_RS09110	COG1404	Belongs to the peptidase S8 family
MPR_RS09115	COG3956	TIGRFAM MazG family protein
MPR_RS09125	COG0242	peptide deformylase activity
MPR_RS09230	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
MPR_RS09245	COG0656	L-ascorbic acid biosynthetic process
MPR_RS09275	COG1629	transport
MPR_RS09275	COG4206	TonB-dependent receptor
MPR_RS09290	COG0730	response to heat
MPR_RS09300	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
MPR_RS09305	COG1648	precorrin-2 dehydrogenase activity
MPR_RS09305	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MPR_RS09320	COG2895	sulfate adenylyltransferase (ATP) activity
MPR_RS09325	COG0175	sulfate reduction
MPR_RS09330	COG0175	sulfate reduction
MPR_RS09335	COG1959	2 iron, 2 sulfur cluster binding
MPR_RS09345	COG1733	regulation of RNA biosynthetic process
MPR_RS09350	COG4628	conserved protein (DUF2132)
MPR_RS09380	COG0640	Transcriptional regulator
MPR_RS09390	COG0387	Pfam Sodium calcium exchanger
MPR_RS09410	COG4771	TonB-dependent receptor
MPR_RS09420	COG0573	inorganic phosphate transmembrane transporter activity
MPR_RS09425	COG0581	inorganic phosphate transmembrane transporter activity
MPR_RS09430	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
MPR_RS09470	COG1943	Transposase
MPR_RS09495	COG2249	NAD(P)H dehydrogenase (quinone) activity
MPR_RS09500	COG1733	regulation of RNA biosynthetic process
MPR_RS09505	COG1858	cytochrome C peroxidase
MPR_RS09530	COG2312	Erythromycin esterase
MPR_RS09570	COG4106	trans-aconitate 2-methyltransferase activity
MPR_RS09610	COG1252	NADH dehydrogenase
MPR_RS09615	COG3530	Putative quorum-sensing-regulated virulence factor
MPR_RS09620	COG1388	LysM domain
MPR_RS09620	COG0860	N-Acetylmuramoyl-L-alanine amidase
MPR_RS09625	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MPR_RS09625	COG0519	Catalyzes the synthesis of GMP from XMP
MPR_RS09630	COG0786	glutamate:sodium symporter activity
MPR_RS09635	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MPR_RS09640	COG2252	PERMEase
MPR_RS09665	COG3118	belongs to the thioredoxin family
MPR_RS09665	COG0492	ferredoxin-NADP+ reductase activity
MPR_RS09675	COG1063	alcohol dehydrogenase
MPR_RS09685	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
MPR_RS09690	COG1611	Belongs to the LOG family
MPR_RS09695	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MPR_RS09700	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MPR_RS09705	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MPR_RS09710	COG3279	Response regulator of the LytR AlgR family
MPR_RS09720	COG3275	phosphorelay sensor kinase activity
MPR_RS09750	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MPR_RS09755	COG1136	(ABC) transporter
MPR_RS09765	COG0248	Ppx GppA phosphatase
MPR_RS09770	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
MPR_RS09785	COG2877	3-deoxy-8-phosphooctulonate synthase activity
MPR_RS09815	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MPR_RS09835	COG1139	Iron-sulfur cluster binding protein
MPR_RS09840	COG0247	lactate metabolic process
MPR_RS09845	COG1620	l-lactate permease
MPR_RS09865	COG2226	methyltransferase
MPR_RS09905	COG1028	Short-chain dehydrogenase reductase Sdr
MPR_RS09910	COG1757	Na H antiporter
MPR_RS09965	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MPR_RS09975	COG1132	(ABC) transporter
MPR_RS10000	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
MPR_RS10010	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
MPR_RS10015	COG0673	inositol 2-dehydrogenase activity
MPR_RS10020	COG1250	3-hydroxyacyl-CoA dehydrogenase
MPR_RS10035	COG2176	DNA-directed DNA polymerase activity
MPR_RS10040	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MPR_RS10045	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
MPR_RS10070	COG2814	Major facilitator Superfamily
MPR_RS10075	COG1396	sequence-specific DNA binding
MPR_RS10095	COG1063	alcohol dehydrogenase
MPR_RS10130	COG1566	PFAM secretion protein HlyD family protein
MPR_RS10155	COG4977	sequence-specific DNA binding
MPR_RS10155	COG1917	Cupin 2, conserved barrel domain protein
MPR_RS10165	COG0702	epimerase
MPR_RS10180	COG2963	transposase activity
MPR_RS10185	COG2801	Transposase and inactivated derivatives
MPR_RS10210	COG3209	COG3209 Rhs family protein
MPR_RS10370	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MPR_RS10400	COG1396	sequence-specific DNA binding
MPR_RS10445	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
MPR_RS10450	COG0363	glucosamine-6-phosphate deaminase activity
MPR_RS10455	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
MPR_RS10465	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MPR_RS10485	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
MPR_RS10490	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MPR_RS10495	COG1442	glycosyl transferase family 8
MPR_RS10495	COG1216	Glycosyl transferase, family 2
MPR_RS10520	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
MPR_RS10635	COG1629	transport
MPR_RS10675	COG1278	Cold shock
MPR_RS10695	COG2197	response regulator
MPR_RS10700	COG4585	Histidine kinase
MPR_RS10770	COG4585	Histidine kinase
MPR_RS10855	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
MPR_RS10860	COG1088	dTDP-glucose 4,6-dehydratase activity
MPR_RS10865	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
MPR_RS10870	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
MPR_RS10875	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
MPR_RS10885	COG0513	Belongs to the DEAD box helicase family
MPR_RS10890	COG1278	Cold shock
MPR_RS10895	COG1278	Cold shock
MPR_RS10985	COG2207	Transcriptional regulator
MPR_RS11010	COG2837	iron assimilation
MPR_RS11035	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
MPR_RS11040	COG4106	trans-aconitate 2-methyltransferase activity
MPR_RS11040	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
MPR_RS11095	COG0604	alcohol dehydrogenase
MPR_RS11115	COG0328	RNA-DNA hybrid ribonuclease activity
MPR_RS11135	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MPR_RS11145	COG2207	Transcriptional regulator
MPR_RS11145	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MPR_RS11200	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
MPR_RS11215	COG0456	acetyltransferase
MPR_RS11215	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
MPR_RS11230	COG0730	response to heat
MPR_RS11245	COG4753	response regulator
MPR_RS11245	COG2207	Transcriptional regulator
MPR_RS11250	COG4413	Urea transporter
MPR_RS11255	COG0829	nickel cation binding
MPR_RS11260	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
MPR_RS11270	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
MPR_RS11275	COG0804	urea catabolic process
MPR_RS11280	COG0832	Belongs to the urease beta subunit family
MPR_RS11285	COG0831	urea catabolic process
MPR_RS11315	COG1120	ATPase activity
MPR_RS11320	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MPR_RS11330	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
MPR_RS11335	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
MPR_RS11340	COG0375	protein maturation
MPR_RS11355	COG1733	regulation of RNA biosynthetic process
MPR_RS11360	COG0778	Nitroreductase
MPR_RS11365	COG1846	Transcriptional regulator
MPR_RS11415	COG4774	siderophore transport
MPR_RS11445	COG5290	Psort location Cytoplasmic, score
MPR_RS11460	COG0477	Major facilitator Superfamily
MPR_RS11520	COG2249	NAD(P)H dehydrogenase (quinone) activity
MPR_RS11525	COG1733	regulation of RNA biosynthetic process
MPR_RS11540	COG0259	pyridoxamine-phosphate oxidase activity
MPR_RS11545	COG1234	tRNA 3'-trailer cleavage
MPR_RS11560	COG0540	Belongs to the ATCase OTCase family
MPR_RS11565	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
MPR_RS11580	COG0431	NADPH-dependent FMN reductase
MPR_RS11585	COG2885	chlorophyll binding
MPR_RS11590	COG4122	O-methyltransferase activity
MPR_RS11605	COG0077	Prephenate dehydratase
MPR_RS11605	COG1605	Chorismate mutase
MPR_RS11615	COG0386	Belongs to the glutathione peroxidase family
MPR_RS11620	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
MPR_RS11630	COG0402	S-adenosylhomocysteine deaminase activity
MPR_RS11635	COG0666	response to abiotic stimulus
MPR_RS11640	COG2207	Transcriptional regulator
MPR_RS11670	COG5006	permease, DMT superfamily
MPR_RS11680	COG0438	transferase activity, transferring glycosyl groups
MPR_RS11695	COG2814	Major facilitator Superfamily
MPR_RS11710	COG4115	mRNA cleavage
MPR_RS11725	COG3609	addiction module antidote protein, CC2985 family
MPR_RS11745	COG0471	metal ion transport
MPR_RS11750	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MPR_RS11755	COG4589	Belongs to the CDS family
MPR_RS11765	COG1028	Short-chain dehydrogenase reductase Sdr
MPR_RS11775	COG2267	carboxylic ester hydrolase activity
MPR_RS11785	COG2972	Histidine kinase
MPR_RS11800	COG3340	Belongs to the peptidase S51 family
MPR_RS11815	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
MPR_RS11820	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
MPR_RS11825	COG0440	acetolactate synthase activity
MPR_RS11830	COG0028	Belongs to the TPP enzyme family
MPR_RS11835	COG0129	dihydroxy-acid dehydratase activity
MPR_RS11850	COG1280	lysine exporter protein (LysE YggA)
MPR_RS11855	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MPR_RS11860	COG0697	spore germination
MPR_RS11870	COG0210	DNA helicase
MPR_RS11885	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
MPR_RS11890	COG1132	(ABC) transporter
MPR_RS11895	COG1132	(ABC) transporter
MPR_RS11895	COG2375	cellular response to nickel ion
MPR_RS11925	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MPR_RS11930	COG0697	spore germination
MPR_RS11950	COG4607	ABC-type enterochelin transport system periplasmic component
MPR_RS11955	COG4574	serine-type endopeptidase inhibitor activity
MPR_RS11960	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
MPR_RS11985	COG0745	RESPONSE REGULATOR receiver
MPR_RS12000	COG0488	(ABC) transporter
MPR_RS12020	COG0456	acetyltransferase
MPR_RS12025	COG4585	Histidine kinase
MPR_RS12035	COG2197	response regulator
MPR_RS12065	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MPR_RS12140	COG4974	Belongs to the 'phage' integrase family
MPR_RS12195	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
MPR_RS12240	COG1741	Belongs to the pirin family
MPR_RS12260	COG2076	Multidrug Resistance protein
MPR_RS12295	COG2365	Tyrosine phosphatase family
MPR_RS12300	COG0753	catalase activity
MPR_RS12310	COG4585	Histidine kinase
MPR_RS12315	COG0415	Belongs to the DNA photolyase family
MPR_RS12320	COG0471	metal ion transport
MPR_RS12330	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
MPR_RS12335	COG1053	succinate dehydrogenase
MPR_RS12350	COG0477	Major facilitator Superfamily
MPR_RS12355	COG0512	Glutamine amidotransferase of anthranilate synthase
MPR_RS12365	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MPR_RS12390	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MPR_RS12405	COG1045	serine acetyltransferase
MPR_RS12415	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
MPR_RS12430	COG1757	Na H antiporter
MPR_RS12435	COG0516	GMP reductase activity
MPR_RS12435	COG0517	IMP dehydrogenase activity
MPR_RS12445	COG1280	lysine exporter protein (LysE YggA)
MPR_RS12450	COG0167	dihydroorotate dehydrogenase activity
MPR_RS12465	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
MPR_RS12490	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MPR_RS12490	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
MPR_RS12520	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
MPR_RS12525	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MPR_RS12535	COG0742	ribosomal rna small subunit methyltransferase
MPR_RS12555	COG0861	Integral membrane protein TerC family
MPR_RS12565	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
MPR_RS12590	COG1333	cytochrome c biogenesis protein
MPR_RS12590	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MPR_RS12600	COG2885	chlorophyll binding
MPR_RS12630	COG2197	response regulator
MPR_RS12635	COG0140	phosphoribosyl-ATP diphosphatase activity
MPR_RS12635	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
MPR_RS12640	COG0107	imidazoleglycerol-phosphate synthase activity
MPR_RS12645	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
MPR_RS12655	COG0131	Imidazoleglycerol-phosphate dehydratase
MPR_RS12655	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
MPR_RS12660	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MPR_RS12665	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
MPR_RS12670	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
MPR_RS12685	COG0006	proline dipeptidase activity
MPR_RS12720	COG3177	Filamentation induced by cAMP protein fic
MPR_RS12740	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MPR_RS12800	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
MPR_RS12810	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
MPR_RS12825	COG0601	transmembrane transport
MPR_RS12835	COG0149	triose-phosphate isomerase activity
MPR_RS12850	COG2197	response regulator
MPR_RS12900	COG0798	PFAM Bile acid sodium symporter
MPR_RS12915	COG1943	Transposase
MPR_RS12920	COG1012	belongs to the aldehyde dehydrogenase family
MPR_RS12940	COG2890	protein-(glutamine-N5) methyltransferase activity
MPR_RS12945	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MPR_RS12945	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MPR_RS12950	COG1739	Uncharacterized protein family UPF0029
MPR_RS12970	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
MPR_RS12975	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MPR_RS12995	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
MPR_RS13000	COG0306	phosphate transporter
MPR_RS13010	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
MPR_RS13025	COG2855	membrane
MPR_RS13030	COG0583	DNA-binding transcription factor activity
MPR_RS13035	COG1794	racemase activity, acting on amino acids and derivatives
MPR_RS13055	COG2378	regulation of single-species biofilm formation
MPR_RS13125	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
MPR_RS13135	COG3409	Peptidoglycan-binding domain 1 protein
MPR_RS13135	COG0793	Belongs to the peptidase S41A family
MPR_RS13145	COG0587	DNA-directed DNA polymerase activity
MPR_RS13155	COG1396	sequence-specific DNA binding
MPR_RS13160	COG1063	alcohol dehydrogenase
MPR_RS13180	COG0419	ATPase involved in DNA repair
MPR_RS13275	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MPR_RS13275	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MPR_RS13290	COG1674	ftsk spoiiie
MPR_RS13310	COG0450	alkyl hydroperoxide reductase
MPR_RS13315	COG1757	Na H antiporter
MPR_RS13320	COG3781	membrane
MPR_RS13335	COG0517	IMP dehydrogenase activity
MPR_RS13335	COG0516	GMP reductase activity
MPR_RS13350	COG2207	Transcriptional regulator
MPR_RS13360	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
MPR_RS13385	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MPR_RS13405	COG2171	N-acyltransferase activity
MPR_RS13410	COG1368	sulfuric ester hydrolase activity
MPR_RS13415	COG0463	Glycosyl transferase, family 2
MPR_RS13420	COG0463	Glycosyl transferase, family 2
MPR_RS13440	COG0047	phosphoribosylformylglycinamidine synthase activity
MPR_RS13440	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MPR_RS13455	COG4260	virion core protein, lumpy skin disease virus
MPR_RS13470	COG1696	Membrane protein involved in D-alanine export
MPR_RS13475	COG3584	3D domain protein
MPR_RS13475	COG1388	LysM domain
MPR_RS13485	COG0018	arginyl-trna synthetase
MPR_RS13495	COG1881	PFAM PEBP family protein
MPR_RS13555	COG0285	dihydrofolate synthase activity
MPR_RS13570	COG0811	peptide transport
MPR_RS13575	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
MPR_RS13580	COG1960	acyl-CoA dehydrogenase activity
MPR_RS13590	COG2205	protein histidine kinase activity
MPR_RS13590	COG5002	protein histidine kinase activity
MPR_RS13590	COG0784	Response regulator, receiver
MPR_RS13595	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
MPR_RS13600	COG3047	cAMP biosynthetic process
MPR_RS13600	COG2885	chlorophyll binding
MPR_RS13630	COG2885	chlorophyll binding
MPR_RS13630	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
MPR_RS13655	COG2207	Transcriptional regulator
MPR_RS13655	COG4753	response regulator
MPR_RS13700	COG0254	rRNA binding
MPR_RS13725	COG0463	Glycosyl transferase, family 2
MPR_RS13730	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MPR_RS13735	COG1132	(ABC) transporter
MPR_RS13745	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
MPR_RS13750	COG0105	UTP biosynthetic process
MPR_RS13770	COG1393	Belongs to the ArsC family
MPR_RS13785	COG0133	tryptophan synthase activity
MPR_RS13795	COG0488	(ABC) transporter
MPR_RS13800	COG1408	metallophosphoesterase
MPR_RS13805	COG2972	Histidine kinase
MPR_RS13820	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MPR_RS13865	COG0183	Belongs to the thiolase family
MPR_RS13870	COG0791	NLP P60 protein
MPR_RS13875	COG0513	Belongs to the DEAD box helicase family
MPR_RS13880	COG2211	Major facilitator Superfamily
MPR_RS13885	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
MPR_RS13890	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
MPR_RS13915	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MPR_RS13920	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
MPR_RS13920	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
MPR_RS13925	COG0799	negative regulation of ribosome biogenesis
MPR_RS13930	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MPR_RS13940	COG4589	Belongs to the CDS family
MPR_RS13945	COG0688	phosphatidylethanolamine metabolic process
MPR_RS13955	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
MPR_RS13960	COG0305	Participates in initiation and elongation during chromosome replication
MPR_RS13965	COG0825	malonyl-CoA metabolic process
MPR_RS13980	COG0343	queuine tRNA-ribosyltransferase activity
MPR_RS13985	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MPR_RS14050	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
MPR_RS14055	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
MPR_RS14065	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
MPR_RS14075	COG3958	Transketolase
MPR_RS14080	COG3959	Transketolase, thiamine diphosphate binding domain
MPR_RS14095	COG1629	transport
MPR_RS14100	COG1120	ATPase activity
MPR_RS14105	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
MPR_RS14120	COG2195	Cleaves the N-terminal amino acid of tripeptides
MPR_RS14125	COG3853	Toxic anion resistance protein (TelA)
MPR_RS14155	COG0697	spore germination
MPR_RS14195	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
MPR_RS14200	COG0252	asparaginase activity
MPR_RS14240	COG2824	Alkylphosphonate utilization operon protein PhnA
MPR_RS14245	COG2759	Belongs to the formate--tetrahydrofolate ligase family
MPR_RS14285	COG0419	ATPase involved in DNA repair
MPR_RS14290	COG0420	3'-5' exonuclease activity
MPR_RS14305	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
MPR_RS14315	COG2807	transmembrane transport
MPR_RS14355	COG1611	Belongs to the LOG family
MPR_RS14370	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MPR_RS14405	COG1482	cell wall glycoprotein biosynthetic process
MPR_RS14410	COG0720	synthase
MPR_RS14415	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
MPR_RS14430	COG0514	ATP-dependent DNA helicase (RecQ)
MPR_RS14435	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
MPR_RS14435	COG0517	IMP dehydrogenase activity
MPR_RS14440	COG0805	protein transport
MPR_RS14445	COG1137	ATPase activity
MPR_RS14465	COG3279	Response regulator of the LytR AlgR family
MPR_RS14485	COG0497	DNA recombination
MPR_RS14510	COG1528	Iron-storage protein
MPR_RS14515	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MPR_RS14525	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
MPR_RS14540	COG0359	binds to the 23S rRNA
MPR_RS14545	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
MPR_RS14550	COG0360	Binds together with S18 to 16S ribosomal RNA
MPR_RS14560	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
MPR_RS14610	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
MPR_RS14620	COG0492	ferredoxin-NADP+ reductase activity
MPR_RS14630	COG0814	amino acid
MPR_RS14635	COG0814	amino acid
MPR_RS14640	COG2910	NAD(P)H-binding
MPR_RS14645	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
MPR_RS14655	COG0525	valine-tRNA ligase activity
MPR_RS14695	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MPR_RS14700	COG2814	Major facilitator Superfamily
MPR_RS14705	COG1573	uracil-dna glycosylase
MPR_RS14715	COG2814	Major facilitator Superfamily
MPR_RS14725	COG1253	flavin adenine dinucleotide binding
MPR_RS14730	COG0295	cytidine deaminase activity
MPR_RS14740	COG1262	PFAM Formylglycine-generating sulfatase enzyme
MPR_RS14745	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
MPR_RS14765	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
MPR_RS14770	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
MPR_RS14780	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
MPR_RS14785	COG0812	UDP-N-acetylmuramate dehydrogenase activity
MPR_RS14810	COG1999	signal sequence binding
MPR_RS14825	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
MPR_RS14835	COG1959	2 iron, 2 sulfur cluster binding
MPR_RS14850	COG0552	protein localization to endoplasmic reticulum
MPR_RS14855	COG0267	Belongs to the bacterial ribosomal protein bL33 family
MPR_RS14860	COG0227	Belongs to the bacterial ribosomal protein bL28 family
MPR_RS14865	COG1058	Belongs to the CinA family
MPR_RS14865	COG1546	Belongs to the CinA family
MPR_RS14875	COG0179	Fumarylacetoacetate (FAA) hydrolase
MPR_RS14885	COG1858	cytochrome C peroxidase
MPR_RS14920	COG1733	regulation of RNA biosynthetic process
MPR_RS14975	COG1061	Type III restriction enzyme res subunit
MPR_RS14990	COG0590	tRNA wobble adenosine to inosine editing
MPR_RS15025	COG1690	Belongs to the RtcB family
MPR_RS15065	COG0508	dehydrogenase complex catalyzes the overall conversion of
MPR_RS15070	COG1217	gtp-binding protein TYPA
MPR_RS15075	COG0268	Binds directly to 16S ribosomal RNA
MPR_RS15115	COG0442	prolyl-tRNA aminoacylation
MPR_RS15135	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MPR_RS15145	COG0471	metal ion transport
MPR_RS15160	COG3290	protein histidine kinase activity
MPR_RS15175	COG0242	peptide deformylase activity
MPR_RS15210	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MPR_RS15215	COG0534	Mate efflux family protein
MPR_RS15240	COG4206	TonB-dependent receptor
MPR_RS15260	COG0148	phosphopyruvate hydratase activity
MPR_RS15265	COG0505	Belongs to the CarA family
MPR_RS15270	COG0203	ribosomal protein L17
MPR_RS15275	COG0202	RNA polymerase activity
MPR_RS15280	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
MPR_RS15285	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
MPR_RS15290	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
MPR_RS15295	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
MPR_RS15305	COG0200	Binds to the 23S rRNA
MPR_RS15310	COG1841	ribosomal large subunit assembly
MPR_RS15315	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
MPR_RS15320	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
MPR_RS15325	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
MPR_RS15330	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
MPR_RS15335	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
MPR_RS15340	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
MPR_RS15345	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
MPR_RS15350	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
MPR_RS15355	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
MPR_RS15360	COG0255	Belongs to the universal ribosomal protein uL29 family
MPR_RS15365	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
MPR_RS15370	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
MPR_RS15375	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
MPR_RS15380	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
MPR_RS15385	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
MPR_RS15390	COG0089	rRNA binding
MPR_RS15395	COG0088	Forms part of the polypeptide exit tunnel
MPR_RS15400	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
MPR_RS15405	COG0051	transcription antitermination factor activity, RNA binding
MPR_RS15410	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MPR_RS15415	COG0049	tRNA binding
MPR_RS15420	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
MPR_RS15425	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MPR_RS15440	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
MPR_RS15450	COG2003	Belongs to the UPF0758 family
MPR_RS15455	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
MPR_RS15470	COG3591	Belongs to the peptidase S1B family
MPR_RS15475	COG1320	monovalent cation:proton antiporter activity
MPR_RS15480	COG2212	antiporter activity
MPR_RS15485	COG1863	multisubunit Na H antiporter MnhE subunit
MPR_RS15490	COG0651	ATP synthesis coupled electron transport
MPR_RS15495	COG1006	Multisubunit Na H antiporter MnhC subunit
MPR_RS15505	COG2111	Na H antiporter
MPR_RS15505	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MPR_RS15510	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MPR_RS15515	COG0563	adenylate kinase activity
MPR_RS15525	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
MPR_RS15530	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
MPR_RS15670	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
MPR_RS15690	COG3655	Transcriptional regulator
MPR_RS15700	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MPR_RS15700	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MPR_RS15725	COG0671	phosphoesterase, PA-phosphatase related
MPR_RS15735	COG2814	Major facilitator Superfamily
MPR_RS15740	COG0697	spore germination
MPR_RS15755	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
MPR_RS15760	COG1127	ABC transporter
MPR_RS15790	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
MPR_RS15800	COG4206	TonB-dependent receptor
MPR_RS15800	COG1629	transport
MPR_RS15820	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MPR_RS15825	COG0085	RNA polymerase activity
MPR_RS15830	COG0222	ribosome binding
MPR_RS15835	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
MPR_RS15840	COG0081	regulation of translation
MPR_RS15845	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
MPR_RS15890	COG4974	Belongs to the 'phage' integrase family
MPR_RS15895	COG0828	Belongs to the bacterial ribosomal protein bS21 family
MPR_RS15915	COG3275	phosphorelay sensor kinase activity
MPR_RS15930	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MPR_RS15945	COG1960	acyl-CoA dehydrogenase activity
MPR_RS15950	COG1555	photosystem II stabilization
MPR_RS15950	COG1596	polysaccharide export
MPR_RS15980	COG4206	TonB-dependent receptor
MPR_RS15980	COG1629	transport
MPR_RS15990	COG1629	transport
MPR_RS16005	COG4206	TonB-dependent receptor
MPR_RS16005	COG1629	transport
MPR_RS16010	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
MPR_RS16015	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
MPR_RS16020	COG1388	LysM domain
MPR_RS16020	COG0791	NLP P60 protein
MPR_RS16035	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
MPR_RS16060	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MPR_RS16065	COG0739	heme binding
MPR_RS16075	COG1704	LemA family
MPR_RS16095	COG1160	GTP binding
MPR_RS16100	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
MPR_RS16130	COG0488	(ABC) transporter
MPR_RS16155	COG1262	PFAM Formylglycine-generating sulfatase enzyme
MPR_RS16170	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MPR_RS16195	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
MPR_RS16200	COG0459	protein refolding
MPR_RS16215	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
MPR_RS16220	COG0321	lipoyl(octanoyl) transferase activity
MPR_RS16225	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
MPR_RS16240	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MPR_RS16250	COG1185	polyribonucleotide nucleotidyltransferase activity
MPR_RS16255	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
MPR_RS16265	COG3620	sequence-specific DNA binding
MPR_RS16265	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
MPR_RS16265	COG0617	tRNA 3'-terminal CCA addition
MPR_RS16295	COG1610	YqeY-like protein
MPR_RS16335	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
MPR_RS16350	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
MPR_RS16355	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
MPR_RS16360	COG0772	Belongs to the SEDS family
MPR_RS16365	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
MPR_RS16370	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MPR_RS16375	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
MPR_RS16390	COG0275	rRNA processing
MPR_RS16395	COG2001	Belongs to the MraZ family
MPR_RS16405	COG0218	Necessary for normal cell division and for the maintenance of normal septation
MPR_RS16420	COG1629	transport
MPR_RS16425	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
MPR_RS16430	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
MPR_RS16440	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
MPR_RS16445	COG0463	Glycosyl transferase, family 2
MPR_RS16460	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
MPR_RS16465	COG2363	Small membrane protein
MPR_RS16475	COG4172	Belongs to the ABC transporter superfamily
MPR_RS16495	COG4122	O-methyltransferase activity
MPR_RS16530	COG3340	Belongs to the peptidase S51 family
MPR_RS16575	COG1538	Outer membrane efflux protein
MPR_RS16585	COG3118	belongs to the thioredoxin family
MPR_RS16595	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MPR_RS16595	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MPR_RS16625	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
MPR_RS16630	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
MPR_RS16635	COG0052	Belongs to the universal ribosomal protein uS2 family
MPR_RS16640	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
MPR_RS16645	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
MPR_RS16670	COG0351	phosphomethylpyrimidine kinase
MPR_RS16675	COG0352	thiamine-phosphate diphosphorylase activity
MPR_RS16680	COG2022	thiamine diphosphate biosynthetic process
MPR_RS16685	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
MPR_RS16690	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
MPR_RS16695	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
MPR_RS16705	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MPR_RS16710	COG3852	Histidine kinase
MPR_RS16720	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
MPR_RS16755	COG1970	mechanosensitive ion channel activity
MPR_RS16760	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
MPR_RS16790	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MPR_RS16790	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MPR_RS16795	COG3118	belongs to the thioredoxin family
MPR_RS16800	COG0612	Peptidase, M16
MPR_RS16810	COG0481	GTPase activity
MPR_RS16840	COG0693	protein deglycase activity
MPR_RS16845	COG0668	transmembrane transport
MPR_RS16860	COG0823	Involved in the tonB-independent uptake of proteins
MPR_RS16860	COG1506	peptidase
MPR_RS16865	COG1301	dicarboxylic acid transport
MPR_RS16870	COG0586	Pfam SNARE associated Golgi protein
MPR_RS16880	COG0492	ferredoxin-NADP+ reductase activity
MPR_RS16890	COG0489	protein tyrosine kinase activity
MPR_RS16910	COG0577	efflux transmembrane transporter activity
MPR_RS16945	COG1136	(ABC) transporter
MPR_RS16950	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MPR_RS16985	COG0220	tRNA (guanine-N7-)-methyltransferase activity
MPR_RS16990	COG5002	protein histidine kinase activity
MPR_RS16995	COG0745	RESPONSE REGULATOR receiver
MPR_RS17000	COG4771	TonB-dependent receptor
MPR_RS17030	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
MPR_RS17040	COG0358	DNA primase activity
MPR_RS17065	COG0820	rRNA (adenine-C2-)-methyltransferase activity
MPR_RS17080	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
MPR_RS17080	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
MPR_RS17095	COG0113	porphobilinogen synthase activity
MPR_RS17100	COG0408	coproporphyrinogen oxidase activity
MPR_RS17110	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
MPR_RS17120	COG0181	hydroxymethylbilane synthase activity
MPR_RS17125	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
MPR_RS17135	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
MPR_RS17140	COG1981	membrane
MPR_RS17150	COG1024	Enoyl-CoA hydratase
MPR_RS17170	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
MPR_RS17180	COG0439	Biotin carboxylase
MPR_RS17185	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
MPR_RS17230	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MPR_RS17240	COG0423	glycine-tRNA ligase activity
MPR_RS17260	COG1304	FMN binding
MPR_RS17275	COG0702	epimerase
MPR_RS17280	COG1027	Aspartate ammonia-lyase
MPR_RS17285	COG3012	SEC-C Motif Domain Protein
MPR_RS17295	COG1040	competence protein
MPR_RS17310	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MPR_RS17315	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
MPR_RS17320	COG1053	succinate dehydrogenase
MPR_RS17335	COG2267	carboxylic ester hydrolase activity
MPR_RS17355	COG1074	ATP-dependent DNA helicase activity
MPR_RS17360	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
MPR_RS17365	COG0469	pyruvate kinase activity
MPR_RS17375	COG0571	ribonuclease III activity
MPR_RS17380	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MPR_RS17385	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MPR_RS17395	COG0328	RNA-DNA hybrid ribonuclease activity
MPR_RS17430	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
MPR_RS17435	COG0471	metal ion transport
MPR_RS17440	COG1418	mRNA catabolic process
MPR_RS17470	COG0792	nuclease activity
MPR_RS17475	COG1619	proteins homologs of microcin C7 resistance protein MccF
MPR_RS17480	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MPR_RS17495	COG2954	triphosphatase activity
MPR_RS17570	COG1335	isochorismatase
MPR_RS17580	COG4771	TonB-dependent receptor
MPR_RS17590	COG4607	ABC-type enterochelin transport system periplasmic component
MPR_RS17595	COG4607	ABC-type enterochelin transport system periplasmic component
MPR_RS17600	COG1902	pentaerythritol trinitrate reductase activity
MPR_RS17605	COG2814	Major facilitator Superfamily
MPR_RS17610	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
MPR_RS17615	COG0193	aminoacyl-tRNA hydrolase activity
MPR_RS17620	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
MPR_RS17625	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
MPR_RS17680	COG0750	zinc metalloprotease
MPR_RS17685	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
MPR_RS17695	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
MPR_RS17700	COG2239	Acts as a magnesium transporter
MPR_RS17705	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MPR_RS17715	COG0708	Exodeoxyribonuclease III
MPR_RS17720	COG1360	Flagellar Motor Protein
MPR_RS17725	COG0668	transmembrane transport
MPR_RS17735	COG1570	exodeoxyribonuclease VII activity
MPR_RS17740	COG0756	dUTP diphosphatase activity
MPR_RS17765	COG1012	belongs to the aldehyde dehydrogenase family
MPR_RS17785	COG0714	Associated with various cellular activities
MPR_RS17800	COG2304	oxidoreductase activity
MPR_RS17805	COG2304	oxidoreductase activity
MPR_RS17835	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
MPR_RS17845	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
MPR_RS17850	COG0165	Argininosuccinate lyase
MPR_RS17860	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
MPR_RS17875	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
MPR_RS17890	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MPR_RS17895	COG0859	PFAM glycosyl transferase family 9
MPR_RS17905	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
MPR_RS17920	COG0151	Belongs to the GarS family
MPR_RS17935	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
MPR_RS17995	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MPR_RS18000	COG2183	response to ionizing radiation
MPR_RS18155	COG3209	COG3209 Rhs family protein