locus-tag	class	description
A176_RS00035	COG1858	cytochrome C peroxidase
A176_RS00050	COG3594	Acyltransferase
A176_RS00055	COG3781	membrane
A176_RS00070	COG1505	serine-type exopeptidase activity
A176_RS00085	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A176_RS00100	COG1733	regulation of RNA biosynthetic process
A176_RS00115	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A176_RS00140	COG0534	Mate efflux family protein
A176_RS00145	COG1028	Short-chain dehydrogenase reductase Sdr
A176_RS00155	COG1063	alcohol dehydrogenase
A176_RS00195	COG3781	membrane
A176_RS00200	COG2155	Conserved Protein
A176_RS00220	COG1077	Cell shape determining protein MreB Mrl
A176_RS00240	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A176_RS00240	COG4651	solute:proton antiporter activity
A176_RS00250	COG0076	glutamate decarboxylase activity
A176_RS00330	COG2171	N-acyltransferase activity
A176_RS00340	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A176_RS00360	COG2154	pterin-4-alpha-carbinolamine dehydratase
A176_RS00370	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A176_RS00390	COG0577	efflux transmembrane transporter activity
A176_RS00400	COG2267	carboxylic ester hydrolase activity
A176_RS00415	COG0408	coproporphyrinogen oxidase activity
A176_RS00500	COG0583	DNA-binding transcription factor activity
A176_RS00505	COG1028	Short-chain dehydrogenase reductase Sdr
A176_RS00510	COG2133	pyrroloquinoline quinone binding
A176_RS00560	COG5002	protein histidine kinase activity
A176_RS00560	COG2205	protein histidine kinase activity
A176_RS00560	COG0784	Response regulator, receiver
A176_RS00565	COG2205	protein histidine kinase activity
A176_RS00600	COG0697	spore germination
A176_RS00605	COG1420	regulation of RNA biosynthetic process
A176_RS00610	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A176_RS00615	COG1597	lipid kinase activity
A176_RS00625	COG0546	phosphoglycolate phosphatase activity
A176_RS00650	COG1199	ATP-dependent helicase activity
A176_RS00655	COG4206	TonB-dependent receptor
A176_RS00665	COG0024	Methionine aminopeptidase
A176_RS00705	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A176_RS00705	COG0475	glutathione-regulated potassium exporter activity
A176_RS00725	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A176_RS00735	COG0583	DNA-binding transcription factor activity
A176_RS00755	COG0745	RESPONSE REGULATOR receiver
A176_RS00785	COG0583	DNA-binding transcription factor activity
A176_RS00860	COG2137	regulation of response to DNA damage stimulus
A176_RS00880	COG0456	acetyltransferase
A176_RS00885	COG1100	Small GTP-binding protein
A176_RS00910	COG1643	Atp-dependent helicase
A176_RS00950	COG0835	chemotaxis
A176_RS00955	COG2201	protein-glutamate methylesterase activity
A176_RS00960	COG0643	Histidine kinase
A176_RS00960	COG2198	Histidine kinase
A176_RS00970	COG1691	(AIR) carboxylase
A176_RS00975	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
A176_RS00985	COG3852	Histidine kinase
A176_RS01025	COG3209	COG3209 Rhs family protein
A176_RS01045	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A176_RS01050	COG0443	Heat shock 70 kDa protein
A176_RS01075	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
A176_RS01130	COG0442	prolyl-tRNA aminoacylation
A176_RS01180	COG1846	Transcriptional regulator
A176_RS01185	COG0725	ABC transporter, periplasmic molybdate-binding protein
A176_RS01190	COG4149	molybdate abc transporter
A176_RS01195	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
A176_RS01220	COG1755	Isoprenylcysteine carboxyl methyltransferase
A176_RS01225	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A176_RS01230	COG0318	PFAM AMP-dependent synthetase and ligase
A176_RS01260	COG0277	FAD linked oxidase domain protein
A176_RS01265	COG0546	phosphoglycolate phosphatase activity
A176_RS01265	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
A176_RS01280	COG0745	RESPONSE REGULATOR receiver
A176_RS01295	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A176_RS01305	COG1472	Belongs to the glycosyl hydrolase 3 family
A176_RS01315	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
A176_RS01335	COG0513	Belongs to the DEAD box helicase family
A176_RS01355	COG0714	Associated with various cellular activities
A176_RS01365	COG1024	Enoyl-CoA hydratase
A176_RS01370	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A176_RS01380	COG0443	Heat shock 70 kDa protein
A176_RS01390	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
A176_RS01395	COG0823	Involved in the tonB-independent uptake of proteins
A176_RS01395	COG1506	peptidase
A176_RS01485	COG4206	TonB-dependent receptor
A176_RS01500	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A176_RS01515	COG0723	plastoquinol--plastocyanin reductase activity
A176_RS01515	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A176_RS01530	COG1120	ATPase activity
A176_RS01540	COG0537	adenosine 5'-monophosphoramidase activity
A176_RS01545	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
A176_RS01550	COG1660	Displays ATPase and GTPase activities
A176_RS01570	COG0515	serine threonine protein kinase
A176_RS01615	COG4608	Belongs to the ABC transporter superfamily
A176_RS01620	COG0444	Belongs to the ABC transporter superfamily
A176_RS01625	COG0601	transmembrane transport
A176_RS01675	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A176_RS01680	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
A176_RS01680	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A176_RS01685	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A176_RS01690	COG3715	PTS system
A176_RS01695	COG3716	PTS system mannose fructose sorbose family IID component
A176_RS01705	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A176_RS01715	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A176_RS01725	COG0227	Belongs to the bacterial ribosomal protein bL28 family
A176_RS01735	COG0523	cobalamin synthesis protein
A176_RS01740	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A176_RS01745	COG1285	pathogenesis
A176_RS01770	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A176_RS01775	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
A176_RS01785	COG1968	undecaprenyl-diphosphatase activity
A176_RS01805	COG3795	YCII-related domain
A176_RS01810	COG3795	YCII-related domain
A176_RS01825	COG3119	arylsulfatase activity
A176_RS01880	COG1940	carbohydrate kinase activity
A176_RS01885	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
A176_RS01965	COG0667	Aldo Keto reductase
A176_RS01995	COG0714	Associated with various cellular activities
A176_RS02005	COG1131	(ABC) transporter
A176_RS02065	COG1640	4-alpha-glucanotransferase
A176_RS02070	COG2094	Belongs to the DNA glycosylase MPG family
A176_RS02085	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A176_RS02125	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A176_RS02165	COG2224	Isocitrate lyase
A176_RS02170	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
A176_RS02180	COG0114	fumarate hydratase activity
A176_RS02185	COG0740	serine-type endopeptidase activity
A176_RS02205	COG4783	chaperone-mediated protein folding
A176_RS02220	COG1960	acyl-CoA dehydrogenase activity
A176_RS02225	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A176_RS02230	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A176_RS02235	COG0456	acetyltransferase
A176_RS02270	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
A176_RS02275	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
A176_RS02290	COG0745	RESPONSE REGULATOR receiver
A176_RS02320	COG0025	NhaP-type Na H and K H
A176_RS02355	COG1136	(ABC) transporter
A176_RS02355	COG0577	efflux transmembrane transporter activity
A176_RS02360	COG1136	(ABC) transporter
A176_RS02365	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A176_RS02370	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A176_RS02375	COG1028	Short-chain dehydrogenase reductase Sdr
A176_RS02380	COG1028	Short-chain dehydrogenase reductase Sdr
A176_RS02385	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A176_RS02400	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A176_RS02405	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A176_RS02410	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A176_RS02445	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
A176_RS02450	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
A176_RS02455	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A176_RS02460	COG1012	belongs to the aldehyde dehydrogenase family
A176_RS02465	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A176_RS02520	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
A176_RS02525	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
A176_RS02530	COG0235	Class ii aldolase
A176_RS02575	COG0318	PFAM AMP-dependent synthetase and ligase
A176_RS02585	COG0363	glucosamine-6-phosphate deaminase activity
A176_RS02590	COG0741	lytic transglycosylase activity
A176_RS02595	COG1309	transcriptional regulator
A176_RS02650	COG0277	FAD linked oxidase domain protein
A176_RS02655	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A176_RS02690	COG0625	glutathione transferase activity
A176_RS02705	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
A176_RS02725	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A176_RS02730	COG0023	Translation Initiation Factor
A176_RS02745	COG0473	3-isopropylmalate dehydrogenase activity
A176_RS02785	COG1028	Short-chain dehydrogenase reductase Sdr
A176_RS02790	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
A176_RS02800	COG0248	Ppx GppA phosphatase
A176_RS02815	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A176_RS02825	COG0515	serine threonine protein kinase
A176_RS02825	COG2815	serine threonine protein kinase
A176_RS02830	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
A176_RS02835	COG2205	protein histidine kinase activity
A176_RS02840	COG3394	polysaccharide catabolic process
A176_RS02850	COG0515	serine threonine protein kinase
A176_RS02860	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A176_RS02895	COG1994	Peptidase M50
A176_RS02895	COG0517	IMP dehydrogenase activity
A176_RS02905	COG2723	6-phospho-beta-galactosidase activity
A176_RS02925	COG0469	pyruvate kinase activity
A176_RS02930	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
A176_RS02935	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A176_RS03095	COG3338	carbonate dehydratase activity
A176_RS03110	COG1509	lysine 2,3-aminomutase activity
A176_RS03155	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A176_RS03160	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A176_RS03195	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
A176_RS03250	COG0625	glutathione transferase activity
A176_RS03270	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
A176_RS03280	COG2207	Transcriptional regulator
A176_RS03285	COG4221	oxidoreductase activity
A176_RS03320	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A176_RS03360	COG0300	oxidoreductase activity
A176_RS03410	COG0251	oxidation-reduction process
A176_RS03440	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A176_RS03450	COG0438	transferase activity, transferring glycosyl groups
A176_RS03460	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
A176_RS03485	COG0753	catalase activity
A176_RS03485	COG0693	protein deglycase activity
A176_RS03495	COG1760	l-serine dehydratase
A176_RS03530	COG0004	ammonium transporteR
A176_RS03540	COG0583	DNA-binding transcription factor activity
A176_RS03595	COG0515	serine threonine protein kinase
A176_RS03595	COG2815	serine threonine protein kinase
A176_RS03605	COG2204	response regulator
A176_RS03645	COG0657	acetylesterase activity
A176_RS03650	COG1408	metallophosphoesterase
A176_RS03655	COG0300	oxidoreductase activity
A176_RS03710	COG0322	excinuclease ABC activity
A176_RS03780	COG0546	phosphoglycolate phosphatase activity
A176_RS03795	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
A176_RS03805	COG3214	Protein conserved in bacteria
A176_RS03825	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
A176_RS03845	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A176_RS03875	COG0429	hydrolase of the alpha beta-hydrolase fold
A176_RS03920	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A176_RS03955	COG0437	4 iron, 4 sulfur cluster binding
A176_RS03975	COG1201	RNA secondary structure unwinding
A176_RS03980	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
A176_RS03980	COG1793	dna ligase
A176_RS03995	COG0512	Glutamine amidotransferase of anthranilate synthase
A176_RS04000	COG0406	alpha-ribazole phosphatase activity
A176_RS04020	COG0159	tryptophan synthase activity
A176_RS04025	COG0133	tryptophan synthase activity
A176_RS04030	COG0135	phosphoribosylanthranilate isomerase activity
A176_RS04035	COG0134	indole-3-glycerol-phosphate synthase activity
A176_RS04040	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A176_RS04045	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
A176_RS04050	COG1233	COG1233 Phytoene dehydrogenase and related
A176_RS04085	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A176_RS04090	COG2010	Cytochrome c
A176_RS04090	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A176_RS04095	COG2080	2 iron, 2 sulfur cluster binding
A176_RS04100	COG2205	protein histidine kinase activity
A176_RS04110	COG0326	Molecular chaperone. Has ATPase activity
A176_RS04130	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
A176_RS04135	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
A176_RS04150	COG4771	TonB-dependent receptor
A176_RS04155	COG2815	serine threonine protein kinase
A176_RS04155	COG0515	serine threonine protein kinase
A176_RS04160	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A176_RS04165	COG1404	Belongs to the peptidase S8 family
A176_RS04165	COG4935	Belongs to the peptidase S8 family
A176_RS04185	COG1278	Cold shock
A176_RS04190	COG0508	dehydrogenase complex catalyzes the overall conversion of
A176_RS04195	COG0567	Dehydrogenase, E1 component
A176_RS04200	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A176_RS04205	COG2205	protein histidine kinase activity
A176_RS04205	COG2198	Histidine kinase
A176_RS04205	COG0784	Response regulator, receiver
A176_RS04215	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
A176_RS04230	COG2201	protein-glutamate methylesterase activity
A176_RS04235	COG0840	transmembrane signaling receptor activity
A176_RS04240	COG0542	response to heat
A176_RS04245	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
A176_RS04295	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
A176_RS04300	COG4191	Histidine kinase
A176_RS04320	COG4377	Putative membrane peptidase family (DUF2324)
A176_RS04390	COG0251	oxidation-reduction process
A176_RS04395	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
A176_RS04405	COG2205	protein histidine kinase activity
A176_RS04415	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
A176_RS04460	COG0037	tRNA processing
A176_RS04480	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A176_RS04505	COG0515	serine threonine protein kinase
A176_RS04515	COG0508	dehydrogenase complex catalyzes the overall conversion of
A176_RS04515	COG0596	Alpha beta hydrolase
A176_RS04575	COG1331	Highly conserved protein containing a thioredoxin domain
A176_RS04590	COG1181	Belongs to the D-alanine--D-alanine ligase family
A176_RS04595	COG1078	dGTPase activity
A176_RS04625	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
A176_RS04630	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
A176_RS04635	COG2096	Adenosyltransferase
A176_RS04645	COG0697	spore germination
A176_RS04670	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
A176_RS04675	COG1295	ribonuclease BN
A176_RS04680	COG4783	chaperone-mediated protein folding
A176_RS04700	COG0019	diaminopimelate decarboxylase activity
A176_RS04705	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A176_RS04710	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
A176_RS04715	COG0179	Fumarylacetoacetate (FAA) hydrolase
A176_RS04730	COG0517	IMP dehydrogenase activity
A176_RS04730	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
A176_RS04735	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A176_RS04740	COG1960	acyl-CoA dehydrogenase activity
A176_RS04745	COG2086	electron transfer activity
A176_RS04795	COG0284	orotidine-5'-phosphate decarboxylase activity
A176_RS04800	COG0300	oxidoreductase activity
A176_RS04820	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A176_RS04825	COG0805	protein transport
A176_RS04825	COG0805	protein transport
A176_RS04835	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A176_RS04850	COG2169	Transcriptional regulator
A176_RS04850	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A176_RS04890	COG1012	belongs to the aldehyde dehydrogenase family
A176_RS04895	COG2072	flavoprotein involved in K transport
A176_RS04900	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A176_RS04905	COG4266	Belongs to the allantoicase family
A176_RS04915	COG2351	hydroxyisourate hydrolase activity
A176_RS04920	COG3189	MarR family transcriptional regulator
A176_RS04955	COG0183	Belongs to the thiolase family
A176_RS04980	COG3384	dioxygenase
A176_RS04985	COG2353	YceI-like domain
A176_RS05000	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A176_RS05005	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A176_RS05060	COG2032	superoxide dismutase activity
A176_RS05070	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A176_RS05070	COG3453	Protein conserved in bacteria
A176_RS05075	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A176_RS05080	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A176_RS05090	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A176_RS05105	COG2204	response regulator
A176_RS05155	COG0587	DNA-directed DNA polymerase activity
A176_RS05160	COG1024	Enoyl-CoA hydratase
A176_RS05165	COG1605	Chorismate mutase
A176_RS05165	COG0077	Prephenate dehydratase
A176_RS05170	COG0826	peptidase U32
A176_RS05175	COG1028	Short-chain dehydrogenase reductase Sdr
A176_RS05200	COG1309	transcriptional regulator
A176_RS05235	COG0058	SHG alpha-glucan phosphorylase activity
A176_RS05245	COG0739	heme binding
A176_RS05250	COG0667	Aldo Keto reductase
A176_RS05255	COG2719	SpoVR family
A176_RS05260	COG2718	Belongs to the UPF0229 family
A176_RS05265	COG2766	serine protein kinase
A176_RS05280	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
A176_RS05305	COG0003	Pfam Anion-transporting ATPase
A176_RS05320	COG1192	Involved in chromosome partitioning
A176_RS05340	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A176_RS05345	COG0584	glycerophosphoryl diester phosphodiesterase
A176_RS05355	COG0793	Belongs to the peptidase S41A family
A176_RS05365	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
A176_RS05375	COG0443	Heat shock 70 kDa protein
A176_RS05390	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A176_RS05410	COG1199	ATP-dependent helicase activity
A176_RS05435	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A176_RS05445	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A176_RS05455	COG1459	type II secretion system
A176_RS05460	COG4191	Histidine kinase
A176_RS05465	COG2204	response regulator
A176_RS05470	COG4968	Prepilin-type N-terminal cleavage methylation domain
A176_RS05480	COG1131	(ABC) transporter
A176_RS05490	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
A176_RS05495	COG3852	Histidine kinase
A176_RS05500	COG2204	response regulator
A176_RS05540	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A176_RS05545	COG0511	ligase activity, forming carbon-carbon bonds
A176_RS05550	COG0439	Biotin carboxylase
A176_RS05560	COG3409	Peptidoglycan-binding domain 1 protein
A176_RS05560	COG3267	Type II secretory pathway component ExeA
A176_RS05570	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A176_RS05585	COG2814	Major facilitator Superfamily
A176_RS05595	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A176_RS05600	COG0823	Involved in the tonB-independent uptake of proteins
A176_RS05615	COG0811	peptide transport
A176_RS05625	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A176_RS05640	COG2884	Cell division ATP-binding protein ftsE
A176_RS05645	COG2177	Part of the ABC transporter FtsEX involved in
A176_RS05655	COG0508	dehydrogenase complex catalyzes the overall conversion of
A176_RS05655	COG0596	Alpha beta hydrolase
A176_RS05660	COG0793	Belongs to the peptidase S41A family
A176_RS05675	COG1181	Belongs to the D-alanine--D-alanine ligase family
A176_RS05705	COG0552	protein localization to endoplasmic reticulum
A176_RS05720	COG4941	Belongs to the sigma-70 factor family
A176_RS05735	COG0443	Heat shock 70 kDa protein
A176_RS05745	COG0484	heat shock protein binding
A176_RS05790	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
A176_RS05795	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
A176_RS05805	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A176_RS05815	COG4191	Histidine kinase
A176_RS05820	COG1079	Belongs to the binding-protein-dependent transport system permease family
A176_RS05825	COG4603	Belongs to the binding-protein-dependent transport system permease family
A176_RS05830	COG3845	ABC transporter
A176_RS05835	COG1744	ABC transporter substrate-binding protein PnrA-like
A176_RS05860	COG0295	cytidine deaminase activity
A176_RS05865	COG0402	S-adenosylhomocysteine deaminase activity
A176_RS05895	COG1136	(ABC) transporter
A176_RS05910	COG0515	serine threonine protein kinase
A176_RS05940	COG0741	lytic transglycosylase activity
A176_RS05940	COG1388	LysM domain
A176_RS05945	COG0737	Belongs to the 5'-nucleotidase family
A176_RS05955	COG0668	transmembrane transport
A176_RS06020	COG4968	Prepilin-type N-terminal cleavage methylation domain
A176_RS06035	COG2204	response regulator
A176_RS06045	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A176_RS06070	COG0714	Associated with various cellular activities
A176_RS06120	COG0745	RESPONSE REGULATOR receiver
A176_RS06140	COG4669	(LipO)protein
A176_RS06165	COG1987	bacterial-type flagellum assembly
A176_RS06175	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A176_RS06190	COG1295	ribonuclease BN
A176_RS06205	COG1254	Belongs to the acylphosphatase family
A176_RS06210	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A176_RS06215	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
A176_RS06225	COG0628	permease
A176_RS06240	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A176_RS06240	COG0519	Catalyzes the synthesis of GMP from XMP
A176_RS06250	COG1454	alcohol dehydrogenase
A176_RS06315	COG0640	Transcriptional regulator
A176_RS06320	COG1960	acyl-CoA dehydrogenase activity
A176_RS06330	COG2001	Belongs to the MraZ family
A176_RS06340	COG0275	rRNA processing
A176_RS06345	COG3116	cell division
A176_RS06350	COG0768	penicillin binding
A176_RS06355	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A176_RS06360	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A176_RS06365	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A176_RS06370	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A176_RS06380	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A176_RS06385	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A176_RS06390	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A176_RS06395	COG1181	Belongs to the D-alanine--D-alanine ligase family
A176_RS06400	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
A176_RS06415	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A176_RS06425	COG0439	Biotin carboxylase
A176_RS06430	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
A176_RS06435	COG1024	Enoyl-CoA hydratase
A176_RS06440	COG0745	RESPONSE REGULATOR receiver
A176_RS06450	COG0705	Rhomboid family
A176_RS06450	COG0457	Tetratricopeptide repeat
A176_RS06500	COG1132	(ABC) transporter
A176_RS06505	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A176_RS06550	COG2850	peptidyl-arginine hydroxylation
A176_RS06585	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
A176_RS06605	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
A176_RS06630	COG1929	Belongs to the glycerate kinase type-1 family
A176_RS06640	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A176_RS06650	COG3030	protein affecting phage T7 exclusion by the F plasmid
A176_RS06665	COG1858	cytochrome C peroxidase
A176_RS06690	COG0437	4 iron, 4 sulfur cluster binding
A176_RS06715	COG0673	inositol 2-dehydrogenase activity
A176_RS06725	COG0653	protein targeting
A176_RS06740	COG1024	Enoyl-CoA hydratase
A176_RS06745	COG1309	transcriptional regulator
A176_RS06755	COG1309	transcriptional regulator
A176_RS06760	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A176_RS06765	COG0569	domain protein
A176_RS06780	COG2217	Heavy metal translocating P-type atpase
A176_RS06790	COG3278	Belongs to the heme-copper respiratory oxidase family
A176_RS06815	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A176_RS06830	COG0588	phosphoglycerate mutase activity
A176_RS06850	COG1671	Belongs to the UPF0178 family
A176_RS06855	COG3279	Response regulator of the LytR AlgR family
A176_RS06860	COG3275	phosphorelay sensor kinase activity
A176_RS06935	COG1404	Belongs to the peptidase S8 family
A176_RS06965	COG1032	radical SAM domain protein
A176_RS06970	COG0210	DNA helicase
A176_RS06990	COG0745	RESPONSE REGULATOR receiver
A176_RS07000	COG0765	amino acid transport
A176_RS07005	COG1126	abc transporter atp-binding protein
A176_RS07050	COG2319	Wd-40 repeat
A176_RS07050	COG4249	Peptidase C14 caspase catalytic subunit p20
A176_RS07055	COG0583	DNA-binding transcription factor activity
A176_RS07070	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
A176_RS07100	COG3437	response regulator, receiver
A176_RS07100	COG2205	protein histidine kinase activity
A176_RS07100	COG4999	Histidine kinase
A176_RS07100	COG3850	Histidine kinase
A176_RS07105	COG3973	AAA domain
A176_RS07110	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
A176_RS07125	COG1652	LysM domain
A176_RS07135	COG0612	Peptidase, M16
A176_RS07140	COG2321	neutral zinc metallopeptidase
A176_RS07160	COG1366	Belongs to the anti-sigma-factor antagonist family
A176_RS07180	COG1733	regulation of RNA biosynthetic process
A176_RS07240	COG0495	leucyl-tRNA aminoacylation
A176_RS07330	COG5265	(ABC) transporter
A176_RS07345	COG2755	lipolytic protein G-D-S-L family
A176_RS07345	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
A176_RS07365	COG1136	(ABC) transporter
A176_RS07365	COG0577	efflux transmembrane transporter activity
A176_RS07370	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A176_RS07400	COG1175	transmembrane transport
A176_RS07405	COG3842	ATPase activity
A176_RS07420	COG1874	Beta-galactosidase
A176_RS07420	COG0366	Alpha amylase catalytic
A176_RS07425	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
A176_RS07430	COG0183	Belongs to the thiolase family
A176_RS07435	COG1250	3-hydroxyacyl-CoA dehydrogenase
A176_RS07435	COG1024	Enoyl-CoA hydratase
A176_RS07450	COG3394	polysaccharide catabolic process
A176_RS07455	COG1215	transferase activity, transferring glycosyl groups
A176_RS07475	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A176_RS07485	COG0737	Belongs to the 5'-nucleotidase family
A176_RS07490	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
A176_RS07500	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
A176_RS07505	COG2814	Major facilitator Superfamily
A176_RS07525	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A176_RS07530	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A176_RS07535	COG0497	DNA recombination
A176_RS07540	COG0631	protein serine/threonine phosphatase activity
A176_RS07545	COG0739	heme binding
A176_RS07555	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
A176_RS07560	COG0653	protein targeting
A176_RS07565	COG0052	Belongs to the universal ribosomal protein uS2 family
A176_RS07570	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
A176_RS07575	COG0528	UMP kinase activity
A176_RS07580	COG0233	cytoplasmic translational termination
A176_RS07605	COG0493	'glutamate synthase
A176_RS07605	COG0543	2 iron, 2 sulfur cluster binding
A176_RS07670	COG0443	Heat shock 70 kDa protein
A176_RS07675	COG0443	Heat shock 70 kDa protein
A176_RS07695	COG0109	protoheme IX farnesyltransferase activity
A176_RS07700	COG1131	(ABC) transporter
A176_RS07720	COG0745	RESPONSE REGULATOR receiver
A176_RS07735	COG1278	Cold shock
A176_RS07755	COG2909	trisaccharide binding
A176_RS07770	COG0501	Belongs to the peptidase M48B family
A176_RS07780	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A176_RS07905	COG0277	FAD linked oxidase domain protein
A176_RS07985	COG1250	3-hydroxyacyl-CoA dehydrogenase
A176_RS08070	COG0668	transmembrane transport
A176_RS08120	COG0252	asparaginase activity
A176_RS08125	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A176_RS08125	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A176_RS08140	COG2885	chlorophyll binding
A176_RS08140	COG3047	cAMP biosynthetic process
A176_RS08165	COG3279	Response regulator of the LytR AlgR family
A176_RS08190	COG5000	phosphorelay sensor kinase activity
A176_RS08230	COG0515	serine threonine protein kinase
A176_RS08230	COG2815	serine threonine protein kinase
A176_RS08240	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A176_RS08275	COG0232	Belongs to the dGTPase family. Type 2 subfamily
A176_RS08295	COG2135	peptidase activity
A176_RS08315	COG0443	Heat shock 70 kDa protein
A176_RS08320	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
A176_RS08365	COG2204	response regulator
A176_RS08370	COG2885	chlorophyll binding
A176_RS08405	COG2201	protein-glutamate methylesterase activity
A176_RS08410	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
A176_RS08425	COG0254	rRNA binding
A176_RS08440	COG1024	Enoyl-CoA hydratase
A176_RS08440	COG1250	3-hydroxyacyl-CoA dehydrogenase
A176_RS08445	COG0183	Belongs to the thiolase family
A176_RS08450	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A176_RS08485	COG3186	Phenylalanine-4-hydroxylase
A176_RS08495	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A176_RS08500	COG2204	response regulator
A176_RS08505	COG5002	protein histidine kinase activity
A176_RS08535	COG0789	Transcriptional regulator
A176_RS08575	COG0515	serine threonine protein kinase
A176_RS08605	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
A176_RS08615	COG0137	argininosuccinate synthase activity
A176_RS08620	COG0165	Argininosuccinate lyase
A176_RS08630	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A176_RS08635	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A176_RS08655	COG0702	epimerase
A176_RS08660	COG1733	regulation of RNA biosynthetic process
A176_RS08670	COG1473	amidohydrolase
A176_RS08675	COG2311	Membrane
A176_RS08690	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A176_RS08700	COG0542	response to heat
A176_RS08725	COG0352	thiamine-phosphate diphosphorylase activity
A176_RS08730	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
A176_RS08735	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
A176_RS08735	COG0351	phosphomethylpyrimidine kinase
A176_RS08735	COG0352	thiamine-phosphate diphosphorylase activity
A176_RS08745	COG3279	Response regulator of the LytR AlgR family
A176_RS08750	COG3275	phosphorelay sensor kinase activity
A176_RS08760	COG0359	binds to the 23S rRNA
A176_RS08765	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A176_RS08770	COG0360	Binds together with S18 to 16S ribosomal RNA
A176_RS08775	COG0193	aminoacyl-tRNA hydrolase activity
A176_RS08780	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
A176_RS08785	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A176_RS08790	COG2088	sporulation resulting in formation of a cellular spore
A176_RS08800	COG1435	thymidine kinase activity
A176_RS08805	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
A176_RS08825	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A176_RS08855	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A176_RS08925	COG0515	serine threonine protein kinase
A176_RS08935	COG2885	chlorophyll binding
A176_RS08940	COG3284	Transcriptional regulator
A176_RS08945	COG1012	belongs to the aldehyde dehydrogenase family
A176_RS08955	COG2175	clavaminate synthase activity
A176_RS08985	COG0612	Peptidase, M16
A176_RS08990	COG5002	protein histidine kinase activity
A176_RS09055	COG1304	FMN binding
A176_RS09065	COG0083	homoserine kinase activity
A176_RS09115	COG0633	Ferredoxin
A176_RS09125	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
A176_RS09130	COG0316	Belongs to the HesB IscA family
A176_RS09135	COG0822	iron-sulfur transferase activity
A176_RS09140	COG1104	cysteine desulfurase activity
A176_RS09155	COG3011	Protein conserved in bacteria
A176_RS09220	COG4650	regulator
A176_RS09225	COG1690	Belongs to the RtcB family
A176_RS09230	COG0430	RNA-3'-phosphate cyclase activity
A176_RS09235	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A176_RS09260	COG0784	Response regulator, receiver
A176_RS09260	COG0835	chemotaxis
A176_RS09265	COG0217	transcriptional regulatory protein
A176_RS09270	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
A176_RS09275	COG0632	four-way junction helicase activity
A176_RS09290	COG2255	four-way junction helicase activity
A176_RS09300	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
A176_RS09305	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A176_RS09305	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A176_RS09320	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A176_RS09330	COG0730	response to heat
A176_RS09345	COG3800	Transcriptional regulator
A176_RS09345	COG1396	sequence-specific DNA binding
A176_RS09350	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A176_RS09375	COG3220	belongs to the UPF0276 family
A176_RS09410	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
A176_RS09490	COG1231	oxidoreductase activity
A176_RS09495	COG2264	protein methyltransferase activity
A176_RS09525	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A176_RS09530	COG2890	protein-(glutamine-N5) methyltransferase activity
A176_RS09535	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A176_RS09550	COG1253	flavin adenine dinucleotide binding
A176_RS09585	COG0459	protein refolding
A176_RS09590	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
A176_RS09610	COG1758	RNA polymerase activity
A176_RS09625	COG2223	nitrite transmembrane transporter activity
A176_RS09645	COG1595	DNA-templated transcription, initiation
A176_RS09670	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
A176_RS09680	COG5002	protein histidine kinase activity
A176_RS09705	COG1129	ABC transporter
A176_RS09705	COG0842	Transport permease protein
A176_RS09710	COG0527	aspartate kinase activity
A176_RS09725	COG1324	tolerance protein
A176_RS09755	COG1716	ATPase activity
A176_RS09800	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A176_RS09885	COG0514	ATP-dependent DNA helicase (RecQ)
A176_RS09890	COG0583	DNA-binding transcription factor activity
A176_RS09900	COG0154	amidase activity
A176_RS09910	COG0477	Major facilitator Superfamily
A176_RS09925	COG0542	response to heat
A176_RS09950	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A176_RS09960	COG0542	response to heat
A176_RS09970	COG0542	response to heat
A176_RS09990	COG4208	sulfate ABC transporter
A176_RS09995	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
A176_RS10040	COG3157	Type VI secretion system effector, Hcp
A176_RS10090	COG3047	cAMP biosynthetic process
A176_RS10090	COG2885	chlorophyll binding
A176_RS10110	COG1253	flavin adenine dinucleotide binding
A176_RS10115	COG0745	RESPONSE REGULATOR receiver
A176_RS10130	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A176_RS10135	COG0581	inorganic phosphate transmembrane transporter activity
A176_RS10140	COG0573	inorganic phosphate transmembrane transporter activity
A176_RS10145	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
A176_RS10150	COG0745	RESPONSE REGULATOR receiver
A176_RS10165	COG0659	secondary active sulfate transmembrane transporter activity
A176_RS10175	COG0730	response to heat
A176_RS10185	COG2062	phosphohistidine phosphatase, SixA
A176_RS10195	COG5002	protein histidine kinase activity
A176_RS10200	COG0745	RESPONSE REGULATOR receiver
A176_RS10215	COG1399	metal-binding, possibly nucleic acid-binding protein
A176_RS10220	COG0333	Belongs to the bacterial ribosomal protein bL32 family
A176_RS10225	COG0416	fatty acid biosynthetic process
A176_RS10230	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A176_RS10235	COG1028	Short-chain dehydrogenase reductase Sdr
A176_RS10240	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A176_RS10245	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A176_RS10255	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A176_RS10260	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A176_RS10265	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A176_RS10265	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A176_RS10275	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
A176_RS10280	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A176_RS10290	COG0745	RESPONSE REGULATOR receiver
A176_RS10295	COG2198	Histidine kinase
A176_RS10295	COG0784	Response regulator, receiver
A176_RS10295	COG0643	Histidine kinase
A176_RS10295	COG2198	Histidine kinase
A176_RS10295	COG0784	Response regulator, receiver
A176_RS10295	COG0643	Histidine kinase
A176_RS10305	COG0835	chemotaxis
A176_RS10320	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
A176_RS10325	COG2201	protein-glutamate methylesterase activity
A176_RS10330	COG0745	RESPONSE REGULATOR receiver
A176_RS10335	COG1131	(ABC) transporter
A176_RS10345	COG2084	Dehydrogenase
A176_RS10355	COG1629	transport
A176_RS10360	COG0495	leucyl-tRNA aminoacylation
A176_RS10375	COG0268	Binds directly to 16S ribosomal RNA
A176_RS10380	COG3956	TIGRFAM MazG family protein
A176_RS10400	COG1480	7TM receptor with intracellular HD hydrolase
A176_RS10405	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
A176_RS10405	COG0662	Cupin 2, conserved barrel domain protein
A176_RS10420	COG1595	DNA-templated transcription, initiation
A176_RS10430	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
A176_RS10440	COG1136	(ABC) transporter
A176_RS10455	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A176_RS10460	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A176_RS10465	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A176_RS10485	COG2095	MarC family integral membrane protein
A176_RS10495	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A176_RS10505	COG1132	(ABC) transporter
A176_RS10530	COG1663	tetraacyldisaccharide 4'-kinase activity
A176_RS10540	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
A176_RS10540	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A176_RS10550	COG1561	YicC-like family, N-terminal region
A176_RS10555	COG0194	GDP metabolic process
A176_RS10585	COG0515	serine threonine protein kinase
A176_RS10590	COG1509	lysine 2,3-aminomutase activity
A176_RS10595	COG1509	lysine 2,3-aminomutase activity
A176_RS10615	COG2385	sporulation resulting in formation of a cellular spore
A176_RS10620	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
A176_RS10625	COG0343	queuine tRNA-ribosyltransferase activity
A176_RS10630	COG1862	Preprotein translocase
A176_RS10635	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A176_RS10640	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A176_RS10650	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A176_RS10650	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
A176_RS10690	COG1193	negative regulation of DNA recombination
A176_RS10695	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A176_RS10705	COG0714	Associated with various cellular activities
A176_RS10715	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A176_RS10730	COG2030	dehydratase
A176_RS10740	COG1960	acyl-CoA dehydrogenase activity
A176_RS10750	COG0811	peptide transport
A176_RS10770	COG0444	Belongs to the ABC transporter superfamily
A176_RS10775	COG4608	Belongs to the ABC transporter superfamily
A176_RS10880	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
A176_RS10885	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
A176_RS10930	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
A176_RS10955	COG0741	lytic transglycosylase activity
A176_RS11000	COG1215	transferase activity, transferring glycosyl groups
A176_RS11010	COG1216	Glycosyl transferase, family 2
A176_RS11045	COG0477	Major facilitator Superfamily
A176_RS11085	COG1295	ribonuclease BN
A176_RS11100	COG0488	(ABC) transporter
A176_RS11105	COG0343	queuine tRNA-ribosyltransferase activity
A176_RS11110	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
A176_RS11110	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A176_RS11130	COG2885	chlorophyll binding
A176_RS11165	COG2204	response regulator
A176_RS11180	COG0659	secondary active sulfate transmembrane transporter activity
A176_RS11200	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
A176_RS11230	COG0022	dehydrogenase e1 component
A176_RS11240	COG0750	zinc metalloprotease
A176_RS11245	COG2208	phosphoserine phosphatase activity
A176_RS11245	COG2770	Histidine kinase
A176_RS11260	COG4771	TonB-dependent receptor
A176_RS11270	COG0515	serine threonine protein kinase
A176_RS11335	COG1032	radical SAM domain protein
A176_RS11460	COG3321	synthase
A176_RS11460	COG0604	alcohol dehydrogenase
A176_RS11460	COG1028	Short-chain dehydrogenase reductase Sdr
A176_RS11495	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A176_RS11505	COG0667	Aldo Keto reductase
A176_RS11675	COG2433	Pfam Transposase IS66
A176_RS11715	COG0459	protein refolding
A176_RS11725	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A176_RS11725	COG2205	protein histidine kinase activity
A176_RS11735	COG3706	GGDEF domain
A176_RS11750	COG0525	valine-tRNA ligase activity
A176_RS11755	COG0157	Belongs to the NadC ModD family
A176_RS11765	COG0824	Thioesterase
A176_RS11770	COG1494	fructose-1,6-bisphosphatase
A176_RS11785	COG0148	phosphopyruvate hydratase activity
A176_RS11790	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
A176_RS11795	COG0739	heme binding
A176_RS11810	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
A176_RS11815	COG5002	protein histidine kinase activity
A176_RS11850	COG0745	RESPONSE REGULATOR receiver
A176_RS11870	COG3268	Saccharopine dehydrogenase
A176_RS11875	COG0515	serine threonine protein kinase
A176_RS11875	COG2815	serine threonine protein kinase
A176_RS11880	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A176_RS11895	COG0010	Belongs to the arginase family
A176_RS11910	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
A176_RS11915	COG4464	protein tyrosine phosphatase activity
A176_RS11935	COG2119	membrane
A176_RS11965	COG1132	(ABC) transporter
A176_RS11970	COG1132	(ABC) transporter
A176_RS11985	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
A176_RS12005	COG0583	DNA-binding transcription factor activity
A176_RS12015	COG1742	UPF0060 membrane protein
A176_RS12020	COG0318	PFAM AMP-dependent synthetase and ligase
A176_RS12070	COG0631	protein serine/threonine phosphatase activity
A176_RS12085	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A176_RS12095	COG1573	uracil-dna glycosylase
A176_RS12105	COG0604	alcohol dehydrogenase
A176_RS12115	COG0753	catalase activity
A176_RS12120	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
A176_RS12130	COG5012	cobalamin binding
A176_RS12135	COG1607	acyl-coa hydrolase
A176_RS12140	COG3246	L-lysine catabolic process to acetate
A176_RS12190	COG0515	serine threonine protein kinase
A176_RS12200	COG0515	serine threonine protein kinase
A176_RS12200	COG2815	serine threonine protein kinase
A176_RS12210	COG2226	methyltransferase
A176_RS12250	COG0037	tRNA processing
A176_RS12255	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A176_RS12260	COG1741	Belongs to the pirin family
A176_RS12265	COG1741	Belongs to the pirin family
A176_RS12270	COG0583	DNA-binding transcription factor activity
A176_RS12275	COG2353	YceI-like domain
A176_RS12290	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A176_RS12295	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A176_RS12300	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
A176_RS12305	COG0736	holo-[acyl-carrier-protein] synthase activity
A176_RS12310	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
A176_RS12310	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A176_RS12315	COG0802	atpase or kinase
A176_RS12320	COG0121	glutamine amidotransferase
A176_RS12325	COG1228	amidohydrolase
A176_RS12335	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
A176_RS12355	COG2204	response regulator
A176_RS12395	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A176_RS12415	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A176_RS12455	COG4638	Rieske (2fe-2S)
A176_RS12460	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A176_RS12465	COG1960	acyl-CoA dehydrogenase activity
A176_RS12475	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A176_RS12515	COG0003	Pfam Anion-transporting ATPase
A176_RS12625	COG0071	Belongs to the small heat shock protein (HSP20) family
A176_RS12630	COG3425	synthase
A176_RS12645	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
A176_RS12650	COG1309	transcriptional regulator
A176_RS12660	COG2204	response regulator
A176_RS12725	COG3852	Histidine kinase
A176_RS12790	COG2205	protein histidine kinase activity
A176_RS12795	COG0745	RESPONSE REGULATOR receiver
A176_RS12795	COG4566	intracellular signal transduction
A176_RS12800	COG4191	Histidine kinase
A176_RS12805	COG0501	Belongs to the peptidase M48B family
A176_RS12820	COG2204	response regulator
A176_RS12830	COG0516	GMP reductase activity
A176_RS12830	COG0517	IMP dehydrogenase activity
A176_RS12835	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
A176_RS12850	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
A176_RS12850	COG2199	diguanylate cyclase activity
A176_RS12855	COG2022	thiamine diphosphate biosynthetic process
A176_RS12855	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A176_RS12860	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
A176_RS12865	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
A176_RS12870	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A176_RS12875	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
A176_RS12880	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
A176_RS12885	COG0131	Imidazoleglycerol-phosphate dehydratase
A176_RS12890	COG0107	imidazoleglycerol-phosphate synthase activity
A176_RS12900	COG0140	phosphoribosyl-ATP diphosphatase activity
A176_RS12900	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
A176_RS12915	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A176_RS12920	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
A176_RS12945	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A176_RS12945	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A176_RS12950	COG0303	'Molybdopterin
A176_RS12960	COG0557	exoribonuclease II activity
A176_RS12980	COG1408	metallophosphoesterase
A176_RS12985	COG1028	Short-chain dehydrogenase reductase Sdr
A176_RS12995	COG0693	protein deglycase activity
A176_RS13000	COG1136	(ABC) transporter
A176_RS13000	COG0577	efflux transmembrane transporter activity
A176_RS13005	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A176_RS13010	COG1136	(ABC) transporter
A176_RS13020	COG4191	Histidine kinase
A176_RS13025	COG2204	response regulator
A176_RS13050	COG2070	2-Nitropropane dioxygenase
A176_RS13050	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A176_RS13055	COG0300	oxidoreductase activity
A176_RS13055	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A176_RS13055	COG4221	oxidoreductase activity
A176_RS13055	COG3321	synthase
A176_RS13060	COG0300	oxidoreductase activity
A176_RS13060	COG3321	synthase
A176_RS13060	COG4221	oxidoreductase activity
A176_RS13060	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A176_RS13060	COG3321	synthase
A176_RS13060	COG4221	oxidoreductase activity
A176_RS13060	COG0300	oxidoreductase activity
A176_RS13060	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A176_RS13065	COG1028	Short-chain dehydrogenase reductase Sdr
A176_RS13065	COG0318	PFAM AMP-dependent synthetase and ligase
A176_RS13065	COG3321	synthase
A176_RS13065	COG0300	oxidoreductase activity
A176_RS13065	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A176_RS13070	COG3321	synthase
A176_RS13070	COG4221	oxidoreductase activity
A176_RS13070	COG0300	oxidoreductase activity
A176_RS13070	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A176_RS13080	COG2072	flavoprotein involved in K transport
A176_RS13095	COG1193	negative regulation of DNA recombination
A176_RS13110	COG3876	Protein conserved in bacteria
A176_RS13120	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
A176_RS13140	COG0542	response to heat
A176_RS13155	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A176_RS13160	COG1136	(ABC) transporter
A176_RS13165	COG0577	efflux transmembrane transporter activity
A176_RS13165	COG1136	(ABC) transporter
A176_RS13205	COG5002	protein histidine kinase activity
A176_RS13210	COG0745	RESPONSE REGULATOR receiver
A176_RS13225	COG3220	belongs to the UPF0276 family
A176_RS13235	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A176_RS13265	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
A176_RS13265	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
A176_RS13270	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
A176_RS13290	COG1595	DNA-templated transcription, initiation
A176_RS13295	COG0686	Belongs to the AlaDH PNT family
A176_RS13305	COG0745	RESPONSE REGULATOR receiver
A176_RS13360	COG1028	Short-chain dehydrogenase reductase Sdr
A176_RS13365	COG0583	DNA-binding transcription factor activity
A176_RS13370	COG3848	Pyruvate phosphate dikinase
A176_RS13370	COG0574	Belongs to the PEP-utilizing enzyme family
A176_RS13410	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A176_RS13475	COG0113	porphobilinogen synthase activity
A176_RS13490	COG1181	Belongs to the D-alanine--D-alanine ligase family
A176_RS13545	COG1408	metallophosphoesterase
A176_RS13560	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A176_RS13565	COG0513	Belongs to the DEAD box helicase family
A176_RS13585	COG3321	synthase
A176_RS13585	COG0604	alcohol dehydrogenase
A176_RS13585	COG1028	Short-chain dehydrogenase reductase Sdr
A176_RS13600	COG1131	(ABC) transporter
A176_RS13615	COG4585	Histidine kinase
A176_RS13625	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A176_RS13635	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
A176_RS13650	COG2046	Belongs to the sulfate adenylyltransferase family
A176_RS13650	COG0529	Catalyzes the synthesis of activated sulfate
A176_RS13655	COG1606	tRNA processing
A176_RS13675	COG0101	tRNA pseudouridine synthase activity
A176_RS13690	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A176_RS13740	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A176_RS13765	COG0515	serine threonine protein kinase
A176_RS13770	COG0443	Heat shock 70 kDa protein
A176_RS13775	COG2766	serine protein kinase
A176_RS13800	COG0003	Pfam Anion-transporting ATPase
A176_RS13815	COG0825	malonyl-CoA metabolic process
A176_RS13820	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A176_RS13825	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
A176_RS13830	COG0741	lytic transglycosylase activity
A176_RS13840	COG2340	Cysteine-rich secretory protein family
A176_RS13870	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
A176_RS13910	COG2815	serine threonine protein kinase
A176_RS13910	COG0515	serine threonine protein kinase
A176_RS13935	COG1181	Belongs to the D-alanine--D-alanine ligase family
A176_RS13945	COG0823	Involved in the tonB-independent uptake of proteins
A176_RS13960	COG0640	Transcriptional regulator
A176_RS14015	COG0667	Aldo Keto reductase
A176_RS14095	COG0488	(ABC) transporter
A176_RS14105	COG2378	regulation of single-species biofilm formation
A176_RS14110	COG0702	epimerase
A176_RS14150	COG4581	dead DEAH box helicase
A176_RS14225	COG0708	Exodeoxyribonuclease III
A176_RS14255	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A176_RS14280	COG0585	pseudouridine synthase activity
A176_RS14325	COG2133	pyrroloquinoline quinone binding
A176_RS14385	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
A176_RS14390	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A176_RS14400	COG0067	glutamate synthase
A176_RS14400	COG0070	glutamate synthase
A176_RS14400	COG0069	glutamate synthase activity
A176_RS14440	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
A176_RS14445	COG1126	abc transporter atp-binding protein
A176_RS14450	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A176_RS14525	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A176_RS14530	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A176_RS14570	COG0860	N-Acetylmuramoyl-L-alanine amidase
A176_RS14595	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
A176_RS14600	COG2814	Major facilitator Superfamily
A176_RS14605	COG4191	Histidine kinase
A176_RS14605	COG0784	Response regulator, receiver
A176_RS14615	COG1301	dicarboxylic acid transport
A176_RS14625	COG0437	4 iron, 4 sulfur cluster binding
A176_RS14655	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A176_RS14660	COG1845	cytochrome c oxidase, subunit III
A176_RS14660	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A176_RS14665	COG1845	cytochrome c oxidase, subunit III
A176_RS14680	COG1320	monovalent cation:proton antiporter activity
A176_RS14685	COG2212	antiporter activity
A176_RS14690	COG1863	multisubunit Na H antiporter MnhE subunit
A176_RS14695	COG0651	ATP synthesis coupled electron transport
A176_RS14700	COG1006	Multisubunit Na H antiporter MnhC subunit
A176_RS14705	COG2111	Na H antiporter
A176_RS14710	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A176_RS14710	COG2111	Na H antiporter
A176_RS14715	COG1063	alcohol dehydrogenase
A176_RS14725	COG0437	4 iron, 4 sulfur cluster binding
A176_RS14730	COG3383	formate dehydrogenase (NAD+) activity
A176_RS14730	COG0243	molybdopterin cofactor binding
A176_RS14780	COG0398	Pfam SNARE associated Golgi protein
A176_RS14800	COG0475	glutathione-regulated potassium exporter activity
A176_RS14800	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A176_RS14805	COG0009	L-threonylcarbamoyladenylate synthase
A176_RS14815	COG4974	Belongs to the 'phage' integrase family
A176_RS14830	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
A176_RS14835	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
A176_RS14850	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A176_RS14865	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
A176_RS14870	COG1111	helicase
A176_RS14870	COG1205	dead DEAH box helicase
A176_RS14875	COG3359	exonuclease
A176_RS14880	COG1047	Peptidyl-prolyl cis-trans
A176_RS14895	COG1946	Acyl-CoA thioesterase
A176_RS14955	COG1028	Short-chain dehydrogenase reductase Sdr
A176_RS14995	COG3852	Histidine kinase
A176_RS15010	COG0430	RNA-3'-phosphate cyclase activity
A176_RS15020	COG0616	signal peptide processing
A176_RS15050	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A176_RS15075	COG0489	protein tyrosine kinase activity
A176_RS15090	COG1250	3-hydroxyacyl-CoA dehydrogenase
A176_RS15095	COG1024	Enoyl-CoA hydratase
A176_RS15105	COG1960	acyl-CoA dehydrogenase activity
A176_RS15115	COG1960	acyl-CoA dehydrogenase activity
A176_RS15130	COG0183	Belongs to the thiolase family
A176_RS15135	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
A176_RS15140	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
A176_RS15150	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A176_RS15165	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A176_RS15170	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
A176_RS15180	COG0586	Pfam SNARE associated Golgi protein
A176_RS15205	COG0443	Heat shock 70 kDa protein
A176_RS15210	COG0517	IMP dehydrogenase activity
A176_RS15210	COG0516	GMP reductase activity
A176_RS15220	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A176_RS15220	COG0519	Catalyzes the synthesis of GMP from XMP
A176_RS15265	COG1160	GTP binding
A176_RS15270	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A176_RS15285	COG0571	ribonuclease III activity
A176_RS15295	COG1960	acyl-CoA dehydrogenase activity
A176_RS15300	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A176_RS15310	COG1024	Enoyl-CoA hydratase
A176_RS15320	COG0840	transmembrane signaling receptor activity
A176_RS15320	COG3290	protein histidine kinase activity
A176_RS15325	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A176_RS15350	COG0156	8-amino-7-oxononanoate synthase activity
A176_RS15355	COG0456	acetyltransferase
A176_RS15375	COG1830	Aldolase
A176_RS15390	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A176_RS15390	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A176_RS15415	COG2205	protein histidine kinase activity
A176_RS15415	COG2198	Histidine kinase
A176_RS15415	COG0784	Response regulator, receiver
A176_RS15420	COG3781	membrane
A176_RS15425	COG3247	response to pH
A176_RS15430	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A176_RS15465	COG0688	phosphatidylethanolamine metabolic process
A176_RS15515	COG0564	pseudouridine synthase activity
A176_RS15525	COG0612	Peptidase, M16
A176_RS15530	COG2197	response regulator
A176_RS15535	COG0515	serine threonine protein kinase
A176_RS15550	COG2521	methyltransferase
A176_RS15550	COG2136	Putative SAM-dependent methyltransferase
A176_RS15560	COG3706	GGDEF domain
A176_RS15570	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A176_RS15615	COG0515	serine threonine protein kinase
A176_RS15645	COG5002	protein histidine kinase activity
A176_RS15650	COG0745	RESPONSE REGULATOR receiver
A176_RS15660	COG1595	DNA-templated transcription, initiation
A176_RS15665	COG0366	Alpha amylase catalytic
A176_RS15680	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
A176_RS15690	COG0583	DNA-binding transcription factor activity
A176_RS15710	COG0667	Aldo Keto reductase
A176_RS15715	COG0673	inositol 2-dehydrogenase activity
A176_RS15785	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A176_RS15830	COG2801	Transposase and inactivated derivatives
A176_RS15835	COG2963	transposase activity
A176_RS15845	COG1335	isochorismatase
A176_RS15850	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A176_RS15870	COG2076	Multidrug Resistance protein
A176_RS15885	COG1262	PFAM Formylglycine-generating sulfatase enzyme
A176_RS15940	COG0515	serine threonine protein kinase
A176_RS15940	COG3266	domain, Protein
A176_RS15950	COG0776	regulation of translation
A176_RS15955	COG0072	phenylalanine-tRNA ligase activity
A176_RS15960	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
A176_RS15965	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
A176_RS15970	COG0291	Belongs to the bacterial ribosomal protein bL35 family
A176_RS15975	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A176_RS15990	COG0628	permease
A176_RS16010	COG0545	Peptidyl-prolyl cis-trans isomerase
A176_RS16020	COG1278	Cold shock
A176_RS16075	COG2304	oxidoreductase activity
A176_RS16080	COG4305	rare lipoprotein A
A176_RS16085	COG2255	four-way junction helicase activity
A176_RS16120	COG0154	amidase activity
A176_RS16130	COG1404	Belongs to the peptidase S8 family
A176_RS16160	COG0728	peptidoglycan biosynthetic process
A176_RS16175	COG2204	response regulator
A176_RS16190	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
A176_RS16195	COG0792	nuclease activity
A176_RS16205	COG0335	large ribosomal subunit rRNA binding
A176_RS16210	COG0336	Belongs to the RNA methyltransferase TrmD family
A176_RS16215	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
A176_RS16220	COG1837	Belongs to the UPF0109 family
A176_RS16225	COG0228	four-way junction DNA binding
A176_RS16230	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A176_RS16240	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
A176_RS16245	COG0045	succinate-CoA ligase (ADP-forming) activity
A176_RS16250	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A176_RS16255	COG1053	succinate dehydrogenase
A176_RS16265	COG0538	isocitrate dehydrogenase activity
A176_RS16300	COG4948	Mandelate Racemase Muconate Lactonizing
A176_RS16315	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
A176_RS16325	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
A176_RS16330	COG2226	methyltransferase
A176_RS16345	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
A176_RS16350	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A176_RS16360	COG0372	Belongs to the citrate synthase family
A176_RS16365	COG1022	Amp-dependent synthetase and ligase
A176_RS16395	COG0505	Belongs to the CarA family
A176_RS16405	COG0540	Belongs to the ATCase OTCase family
A176_RS16410	COG0681	Belongs to the peptidase S26 family
A176_RS16415	COG0481	GTPase activity
A176_RS16450	COG0776	regulation of translation
A176_RS16460	COG0482	sulfurtransferase activity
A176_RS16465	COG0617	tRNA 3'-terminal CCA addition
A176_RS16485	COG3239	Fatty acid desaturase
A176_RS16550	COG2972	Histidine kinase
A176_RS16560	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
A176_RS16565	COG0529	Catalyzes the synthesis of activated sulfate
A176_RS16600	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
A176_RS16600	COG2146	nitrite reductase [NAD(P)H] activity
A176_RS16630	COG0443	Heat shock 70 kDa protein
A176_RS16650	COG1215	transferase activity, transferring glycosyl groups
A176_RS16665	COG0527	aspartate kinase activity
A176_RS16670	COG2986	histidine ammonia-lyase
A176_RS16700	COG0535	radical SAM domain protein
A176_RS16705	COG1262	PFAM Formylglycine-generating sulfatase enzyme
A176_RS16715	COG0840	transmembrane signaling receptor activity
A176_RS16725	COG2205	protein histidine kinase activity
A176_RS16730	COG0745	RESPONSE REGULATOR receiver
A176_RS16795	COG3590	peptidase
A176_RS16835	COG0583	DNA-binding transcription factor activity
A176_RS16880	COG3501	Rhs element vgr protein
A176_RS16930	COG1058	Belongs to the CinA family
A176_RS16930	COG1546	Belongs to the CinA family
A176_RS16940	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A176_RS16950	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A176_RS16950	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A176_RS16955	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
A176_RS16965	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
A176_RS16970	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A176_RS17045	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
A176_RS17060	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A176_RS17080	COG0242	peptide deformylase activity
A176_RS17130	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A176_RS17145	COG0436	Aminotransferase
A176_RS17150	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
A176_RS17180	COG1217	gtp-binding protein TYPA
A176_RS17225	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
A176_RS17250	COG0741	lytic transglycosylase activity
A176_RS17250	COG0739	heme binding
A176_RS17250	COG1196	nuclear chromosome segregation
A176_RS17260	COG0714	Associated with various cellular activities
A176_RS17275	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A176_RS17280	COG1297	OPT oligopeptide transporter protein
A176_RS17300	COG0564	pseudouridine synthase activity
A176_RS17325	COG1921	L-seryl-tRNASec selenium transferase activity
A176_RS17330	COG1278	Cold shock
A176_RS17335	COG0741	lytic transglycosylase activity
A176_RS17350	COG0488	(ABC) transporter
A176_RS17365	COG1956	GAF domain-containing protein
A176_RS17370	COG2313	pseudouridylate synthase activity
A176_RS17410	COG0203	ribosomal protein L17
A176_RS17415	COG0202	RNA polymerase activity
A176_RS17420	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A176_RS17425	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
A176_RS17430	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A176_RS17435	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A176_RS17440	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A176_RS17445	COG0563	adenylate kinase activity
A176_RS17450	COG0201	protein transport
A176_RS17455	COG0200	Binds to the 23S rRNA
A176_RS17460	COG1841	ribosomal large subunit assembly
A176_RS17465	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
A176_RS17470	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
A176_RS17475	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A176_RS17480	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A176_RS17485	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A176_RS17495	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
A176_RS17500	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
A176_RS17505	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
A176_RS17510	COG0255	Belongs to the universal ribosomal protein uL29 family
A176_RS17515	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
A176_RS17520	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
A176_RS17525	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
A176_RS17530	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A176_RS17535	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
A176_RS17540	COG0089	rRNA binding
A176_RS17545	COG0088	Forms part of the polypeptide exit tunnel
A176_RS17550	COG0051	transcription antitermination factor activity, RNA binding
A176_RS17555	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A176_RS17560	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A176_RS17565	COG0049	tRNA binding
A176_RS17570	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
A176_RS17595	COG5002	protein histidine kinase activity
A176_RS17600	COG0018	arginyl-trna synthetase
A176_RS17650	COG0598	Magnesium transport protein CorA
A176_RS17655	COG2267	carboxylic ester hydrolase activity
A176_RS17690	COG0515	serine threonine protein kinase
A176_RS17690	COG2815	serine threonine protein kinase
A176_RS17710	COG2022	thiamine diphosphate biosynthetic process
A176_RS17715	COG0352	thiamine-phosphate diphosphorylase activity
A176_RS17760	COG1131	(ABC) transporter
A176_RS17780	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
A176_RS17785	COG1138	Cytochrome C-type biogenesis protein
A176_RS17790	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A176_RS17845	COG2909	trisaccharide binding
A176_RS17880	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A176_RS17885	COG0513	Belongs to the DEAD box helicase family
A176_RS17895	COG0564	pseudouridine synthase activity
A176_RS17995	COG2165	general secretion pathway protein
A176_RS18010	COG1132	(ABC) transporter
A176_RS18045	COG3173	Aminoglycoside phosphotransferase
A176_RS18050	COG3088	subunit of a heme lyase
A176_RS18075	COG0391	Required for morphogenesis under gluconeogenic growth conditions
A176_RS18080	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A176_RS18085	COG0489	protein tyrosine kinase activity
A176_RS18115	COG2153	protein acetylation
A176_RS18120	COG1605	Chorismate mutase
A176_RS18120	COG0077	Prephenate dehydratase
A176_RS18125	COG0077	Prephenate dehydratase
A176_RS18125	COG1605	Chorismate mutase
A176_RS18130	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
A176_RS18150	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A176_RS18155	COG2204	response regulator
A176_RS18175	COG0768	penicillin binding
A176_RS18185	COG1131	(ABC) transporter
A176_RS18190	COG0425	Belongs to the sulfur carrier protein TusA family
A176_RS18195	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A176_RS18195	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A176_RS18225	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A176_RS18260	COG0443	Heat shock 70 kDa protein
A176_RS18275	COG2921	Belongs to the UPF0250 family
A176_RS18280	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
A176_RS18290	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A176_RS18305	COG0515	serine threonine protein kinase
A176_RS18305	COG2815	serine threonine protein kinase
A176_RS18310	COG3064	Membrane
A176_RS18310	COG0515	serine threonine protein kinase
A176_RS18310	COG4991	sh3 domain protein
A176_RS18350	COG0657	acetylesterase activity
A176_RS18370	COG1902	pentaerythritol trinitrate reductase activity
A176_RS18375	COG1733	regulation of RNA biosynthetic process
A176_RS18400	COG0515	serine threonine protein kinase
A176_RS18400	COG2815	serine threonine protein kinase
A176_RS18445	COG0330	HflC and HflK could
A176_RS18455	COG2130	NADP-dependent
A176_RS18460	COG0596	Alpha beta hydrolase
A176_RS18465	COG2354	Protein conserved in bacteria
A176_RS18505	COG2205	protein histidine kinase activity
A176_RS18505	COG0784	Response regulator, receiver
A176_RS18510	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
A176_RS18515	COG0745	RESPONSE REGULATOR receiver
A176_RS18520	COG3034	peptidoglycan biosynthetic process
A176_RS18525	COG0277	FAD linked oxidase domain protein
A176_RS18535	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
A176_RS18535	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
A176_RS18545	COG3590	peptidase
A176_RS18590	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A176_RS18595	COG3959	Transketolase, thiamine diphosphate binding domain
A176_RS18600	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A176_RS18610	COG2311	Membrane
A176_RS18620	COG3608	succinylglutamate desuccinylase aspartoacylase
A176_RS18620	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
A176_RS18660	COG5002	protein histidine kinase activity
A176_RS18690	COG1505	serine-type exopeptidase activity
A176_RS18720	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A176_RS18780	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A176_RS18780	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A176_RS18820	COG0751	glycine-tRNA ligase activity
A176_RS18825	COG0752	glycyl-tRNA synthetase alpha subunit
A176_RS18830	COG0515	serine threonine protein kinase
A176_RS18835	COG2205	protein histidine kinase activity
A176_RS18850	COG2204	response regulator
A176_RS18890	COG1381	Involved in DNA repair and RecF pathway recombination
A176_RS18900	COG3063	Type IV pilus biogenesis stability protein PilW
A176_RS18915	COG1196	nuclear chromosome segregation
A176_RS18915	COG0739	heme binding
A176_RS18915	COG0741	lytic transglycosylase activity
A176_RS18930	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A176_RS18935	COG0085	RNA polymerase activity
A176_RS18940	COG0222	ribosome binding
A176_RS18945	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
A176_RS18950	COG0081	regulation of translation
A176_RS18955	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A176_RS18975	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A176_RS18980	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A176_RS19005	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A176_RS19015	COG0189	ligase activity
A176_RS19045	COG1643	Atp-dependent helicase
A176_RS19070	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A176_RS19080	COG1960	acyl-CoA dehydrogenase activity
A176_RS19105	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
A176_RS19110	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A176_RS19110	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A176_RS19115	COG0509	glycine decarboxylation via glycine cleavage system
A176_RS19125	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
A176_RS19140	COG3852	Histidine kinase
A176_RS19175	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A176_RS19180	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
A176_RS19185	COG2840	Smr protein MutS2
A176_RS19195	COG0167	dihydroorotate dehydrogenase activity
A176_RS19205	COG0438	transferase activity, transferring glycosyl groups
A176_RS19220	COG0218	Necessary for normal cell division and for the maintenance of normal septation
A176_RS19235	COG0237	dephospho-CoA kinase activity
A176_RS19260	COG0443	Heat shock 70 kDa protein
A176_RS19265	COG0484	heat shock protein binding
A176_RS19275	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
A176_RS19280	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
A176_RS19310	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
A176_RS19355	COG1496	oxidoreductase activity
A176_RS19370	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A176_RS19375	COG1543	Belongs to the glycosyl hydrolase 57 family
A176_RS19390	COG1196	nuclear chromosome segregation
A176_RS19390	COG0745	RESPONSE REGULATOR receiver
A176_RS19435	COG2205	protein histidine kinase activity
A176_RS19440	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
A176_RS19445	COG0515	serine threonine protein kinase
A176_RS19460	COG1692	metallophosphoesterase
A176_RS19465	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
A176_RS19495	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
A176_RS19510	COG1301	dicarboxylic acid transport
A176_RS19515	COG1960	acyl-CoA dehydrogenase activity
A176_RS19530	COG1846	Transcriptional regulator
A176_RS19540	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A176_RS19550	COG0745	RESPONSE REGULATOR receiver
A176_RS19560	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A176_RS19580	COG0277	FAD linked oxidase domain protein
A176_RS19585	COG0302	gtp cyclohydrolase
A176_RS19615	COG1121	(ABC) transporter
A176_RS19620	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A176_RS19660	COG0670	Belongs to the BI1 family
A176_RS19705	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A176_RS19725	COG3591	Belongs to the peptidase S1B family
A176_RS19725	COG1864	DNA RNA non-specific endonuclease
A176_RS19740	COG0438	transferase activity, transferring glycosyl groups
A176_RS19755	COG0795	lipopolysaccharide-transporting ATPase activity
A176_RS19760	COG0151	Belongs to the GarS family
A176_RS19770	COG0138	bifunctional purine biosynthesis protein purh
A176_RS19775	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A176_RS19785	COG0515	serine threonine protein kinase
A176_RS19805	COG1183	phosphatidylcholine synthase activity
A176_RS19810	COG2366	antibiotic biosynthetic process
A176_RS19850	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A176_RS19865	COG0714	Associated with various cellular activities
A176_RS19890	COG2301	Belongs to the HpcH HpaI aldolase family
A176_RS19910	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A176_RS19960	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A176_RS19980	COG0628	permease
A176_RS19995	COG2072	flavoprotein involved in K transport
A176_RS20035	COG1309	transcriptional regulator
A176_RS20090	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A176_RS20155	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A176_RS20160	COG1739	Uncharacterized protein family UPF0029
A176_RS20165	COG1012	belongs to the aldehyde dehydrogenase family
A176_RS20175	COG0583	DNA-binding transcription factor activity
A176_RS20180	COG1012	belongs to the aldehyde dehydrogenase family
A176_RS20250	COG0149	triose-phosphate isomerase activity
A176_RS20255	COG0126	phosphoglycerate kinase activity
A176_RS20260	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A176_RS20270	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
A176_RS20280	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
A176_RS20290	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A176_RS20305	COG0084	hydrolase, TatD family'
A176_RS20315	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A176_RS20315	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A176_RS20340	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A176_RS20375	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A176_RS20390	COG2301	Belongs to the HpcH HpaI aldolase family
A176_RS20410	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A176_RS20415	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A176_RS20445	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A176_RS20475	COG0534	Mate efflux family protein
A176_RS20485	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
A176_RS20495	COG2205	protein histidine kinase activity
A176_RS20495	COG2202	Pas domain
A176_RS20505	COG0577	efflux transmembrane transporter activity
A176_RS20510	COG0657	acetylesterase activity
A176_RS20575	COG0521	Mo-molybdopterin cofactor biosynthetic process
A176_RS20615	COG1366	Belongs to the anti-sigma-factor antagonist family
A176_RS20640	COG0443	Heat shock 70 kDa protein
A176_RS20650	COG0484	heat shock protein binding
A176_RS20665	COG1166	arginine decarboxylase activity
A176_RS20685	COG0613	PHP domain protein
A176_RS20710	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A176_RS20715	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A176_RS20725	COG3119	arylsulfatase activity
A176_RS20735	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A176_RS20740	COG0649	NAD binding
A176_RS20745	COG1034	ATP synthesis coupled electron transport
A176_RS20750	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
A176_RS20755	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A176_RS20815	COG0739	heme binding
A176_RS20815	COG0741	lytic transglycosylase activity
A176_RS20815	COG1196	nuclear chromosome segregation
A176_RS20820	COG1024	Enoyl-CoA hydratase
A176_RS20825	COG1309	transcriptional regulator
A176_RS20835	COG1396	sequence-specific DNA binding
A176_RS20860	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
A176_RS20870	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A176_RS20875	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
A176_RS20880	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A176_RS20885	COG1683	Conserved Protein
A176_RS20890	COG1024	Enoyl-CoA hydratase
A176_RS20895	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A176_RS20905	COG0227	Belongs to the bacterial ribosomal protein bL28 family
A176_RS20910	COG1100	Small GTP-binding protein
A176_RS20935	COG4191	Histidine kinase
A176_RS20970	COG0784	Response regulator, receiver
A176_RS20990	COG0515	serine threonine protein kinase
A176_RS20990	COG2815	serine threonine protein kinase
A176_RS21015	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A176_RS21045	COG3852	Histidine kinase
A176_RS21060	COG0508	dehydrogenase complex catalyzes the overall conversion of
A176_RS21070	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A176_RS21120	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A176_RS21125	COG1587	Uroporphyrinogen-III synthase
A176_RS21130	COG0181	hydroxymethylbilane synthase activity
A176_RS21135	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
A176_RS21150	COG3118	belongs to the thioredoxin family
A176_RS21170	COG0772	Belongs to the SEDS family
A176_RS21185	COG1792	Involved in formation and maintenance of cell shape
A176_RS21190	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A176_RS21195	COG3706	GGDEF domain
A176_RS21200	COG0424	maF-like protein
A176_RS21235	COG3487	Iron-regulated protein
A176_RS21260	COG0322	excinuclease ABC activity
A176_RS21265	COG0556	nucleotide-excision repair
A176_RS21275	COG0215	cysteine-tRNA ligase activity
A176_RS21290	COG1329	Transcriptional regulator
A176_RS21295	COG2333	competence protein COMEC
A176_RS21295	COG0658	competence protein
A176_RS21335	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
A176_RS21340	COG1074	ATP-dependent DNA helicase activity
A176_RS21370	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A176_RS21385	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A176_RS21395	COG3104	oligopeptide transport
A176_RS21415	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
A176_RS21460	COG0584	glycerophosphoryl diester phosphodiesterase
A176_RS21480	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A176_RS21490	COG0515	serine threonine protein kinase
A176_RS21530	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A176_RS21550	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A176_RS21560	COG0588	phosphoglycerate mutase activity
A176_RS21565	COG0156	8-amino-7-oxononanoate synthase activity
A176_RS21570	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A176_RS21580	COG0494	nUDIX hydrolase
A176_RS21585	COG0750	zinc metalloprotease
A176_RS21600	COG0314	molybdopterin synthase activity
A176_RS21620	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A176_RS21625	COG1214	PFAM Peptidase M22, glycoprotease
A176_RS21630	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A176_RS21635	COG0750	zinc metalloprotease
A176_RS21640	COG4589	Belongs to the CDS family
A176_RS21645	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A176_RS21685	COG0564	pseudouridine synthase activity
A176_RS21695	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A176_RS21710	COG0416	fatty acid biosynthetic process
A176_RS21745	COG1022	Amp-dependent synthetase and ligase
A176_RS21750	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
A176_RS21755	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
A176_RS21760	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A176_RS21765	COG2130	NADP-dependent
A176_RS21775	COG5001	Diguanylate cyclase
A176_RS21775	COG3300	MHYT domain
A176_RS21840	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A176_RS21850	COG0312	modulator of DNA gyrase
A176_RS21855	COG0312	modulator of DNA gyrase
A176_RS21885	COG1459	type II secretion system
A176_RS21990	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A176_RS22000	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A176_RS22005	COG0187	DNA topoisomerase II activity
A176_RS22020	COG0616	signal peptide processing
A176_RS22045	COG0714	Associated with various cellular activities
A176_RS22055	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
A176_RS22100	COG1716	ATPase activity
A176_RS22105	COG4789	Type iii secretion
A176_RS22160	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A176_RS22165	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A176_RS22175	COG1987	bacterial-type flagellum assembly
A176_RS22230	COG1191	sigma factor activity
A176_RS22265	COG1136	(ABC) transporter
A176_RS22275	COG0577	efflux transmembrane transporter activity
A176_RS22275	COG1136	(ABC) transporter
A176_RS22295	COG4943	cyclic-guanylate-specific phosphodiesterase activity
A176_RS22320	COG4953	penicillin-binding protein 1C
A176_RS22330	COG2373	Large extracellular alpha-helical protein
A176_RS22335	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
A176_RS22345	COG1187	pseudouridine synthase activity
A176_RS22365	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A176_RS22370	COG0488	(ABC) transporter
A176_RS22385	COG1047	Peptidyl-prolyl cis-trans
A176_RS22390	COG1301	dicarboxylic acid transport
A176_RS22410	COG0515	serine threonine protein kinase
A176_RS22410	COG3064	Membrane
A176_RS22410	COG4991	sh3 domain protein
A176_RS22425	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A176_RS22470	COG0386	Belongs to the glutathione peroxidase family
A176_RS22475	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A176_RS22490	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
A176_RS22500	COG2943	transferase activity, transferring hexosyl groups
A176_RS22540	COG2363	Small membrane protein
A176_RS22550	COG1228	amidohydrolase
A176_RS22555	COG0402	S-adenosylhomocysteine deaminase activity
A176_RS22565	COG3663	DNA glycosylase
A176_RS22575	COG1218	3'(2'),5'-bisphosphate nucleotidase
A176_RS22580	COG5002	protein histidine kinase activity
A176_RS22600	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A176_RS22605	COG0438	transferase activity, transferring glycosyl groups
A176_RS22615	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
A176_RS22620	COG1215	transferase activity, transferring glycosyl groups
A176_RS22625	COG0019	diaminopimelate decarboxylase activity
A176_RS22630	COG1181	Belongs to the D-alanine--D-alanine ligase family
A176_RS22660	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A176_RS22665	COG0517	IMP dehydrogenase activity
A176_RS22670	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A176_RS22675	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A176_RS22675	COG0047	phosphoribosylformylglycinamidine synthase activity
A176_RS22715	COG0175	sulfate reduction
A176_RS22720	COG1648	precorrin-2 dehydrogenase activity
A176_RS22720	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A176_RS22725	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A176_RS22725	COG1648	precorrin-2 dehydrogenase activity
A176_RS22730	COG0175	sulfate reduction
A176_RS22735	COG2895	sulfate adenylyltransferase (ATP) activity
A176_RS22740	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
A176_RS22745	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A176_RS22760	COG0741	lytic transglycosylase activity
A176_RS22760	COG1196	nuclear chromosome segregation
A176_RS22760	COG0739	heme binding
A176_RS22770	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
A176_RS22780	COG2153	protein acetylation
A176_RS22790	COG1012	belongs to the aldehyde dehydrogenase family
A176_RS22795	COG1072	(Pantothenic acid kinase))
A176_RS22800	COG3228	Belongs to the MtfA family
A176_RS22820	COG3541	Predicted nucleotidyltransferase
A176_RS22855	COG0604	alcohol dehydrogenase
A176_RS22855	COG3321	synthase
A176_RS22855	COG1028	Short-chain dehydrogenase reductase Sdr
A176_RS22875	COG0513	Belongs to the DEAD box helicase family
A176_RS22900	COG0813	purine-nucleoside phosphorylase activity
A176_RS22910	COG2124	cytochrome p450
A176_RS22935	COG0017	Asparaginyl-tRNA synthetase
A176_RS22950	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
A176_RS22980	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A176_RS22990	COG0351	phosphomethylpyrimidine kinase
A176_RS22995	COG0339	signal peptide processing
A176_RS23010	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A176_RS23025	COG0306	phosphate transporter
A176_RS23080	COG2070	2-Nitropropane dioxygenase
A176_RS23090	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
A176_RS23095	COG0328	RNA-DNA hybrid ribonuclease activity
A176_RS23110	COG1703	isobutyryl-CoA mutase activity
A176_RS23115	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A176_RS23115	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A176_RS23115	COG1703	isobutyryl-CoA mutase activity
A176_RS23125	COG4651	solute:proton antiporter activity
A176_RS23125	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A176_RS23130	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A176_RS23145	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A176_RS23165	COG3869	Catalyzes the specific phosphorylation of arginine residues in
A176_RS23175	COG4176	ABC-type proline glycine betaine transport system permease component
A176_RS23235	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A176_RS23275	COG0737	Belongs to the 5'-nucleotidase family
A176_RS23290	COG3226	Transcriptional regulator
A176_RS23330	COG2909	trisaccharide binding
A176_RS23350	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A176_RS23360	COG1404	Belongs to the peptidase S8 family
A176_RS23365	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
A176_RS23365	COG2755	lipolytic protein G-D-S-L family
A176_RS23415	COG1268	BioY protein
A176_RS23515	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A176_RS23540	COG2204	response regulator
A176_RS23580	COG1104	cysteine desulfurase activity
A176_RS23590	COG1643	Atp-dependent helicase
A176_RS23615	COG1819	glycosyl
A176_RS23640	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
A176_RS23675	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A176_RS23695	COG0210	DNA helicase
A176_RS23700	COG0612	Peptidase, M16
A176_RS23715	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A176_RS23730	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A176_RS23740	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
A176_RS23755	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A176_RS23765	COG2815	serine threonine protein kinase
A176_RS23765	COG0515	serine threonine protein kinase
A176_RS23770	COG0756	dUTP diphosphatase activity
A176_RS23775	COG0739	heme binding
A176_RS23785	COG1185	polyribonucleotide nucleotidyltransferase activity
A176_RS23790	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
A176_RS23795	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A176_RS23800	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
A176_RS23820	COG0779	Required for maturation of 30S ribosomal subunits
A176_RS23840	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
A176_RS23860	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
A176_RS23865	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
A176_RS23870	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
A176_RS23875	COG1428	Deoxynucleoside kinase
A176_RS23885	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A176_RS23890	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A176_RS23920	COG0631	protein serine/threonine phosphatase activity
A176_RS23925	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
A176_RS23940	COG2030	dehydratase
A176_RS23960	COG0626	cystathionine gamma-synthase activity
A176_RS23965	COG1024	Enoyl-CoA hydratase
A176_RS23990	COG3148	PFAM DTW domain containing protein
A176_RS24000	COG0006	proline dipeptidase activity
A176_RS24010	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
A176_RS24015	COG0271	Belongs to the BolA IbaG family
A176_RS24020	COG1678	Uncharacterized ACR, COG1678
A176_RS24035	COG4168	peptide transport system, permease
A176_RS24040	COG4166	transmembrane transport
A176_RS24050	COG1505	serine-type exopeptidase activity
A176_RS24060	COG0740	serine-type endopeptidase activity
A176_RS24065	COG0544	peptidyl-prolyl cis-trans isomerase activity
A176_RS24110	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A176_RS24115	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
A176_RS24120	COG0860	N-Acetylmuramoyl-L-alanine amidase
A176_RS24125	COG0709	Synthesizes selenophosphate from selenide and ATP
A176_RS24150	COG2137	regulation of response to DNA damage stimulus
A176_RS24170	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
A176_RS24175	COG0210	DNA helicase
A176_RS24200	COG0424	maF-like protein
A176_RS24235	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
A176_RS24245	COG1028	Short-chain dehydrogenase reductase Sdr
A176_RS24270	COG0646	methionine synthase
A176_RS24270	COG1410	methionine synthase
A176_RS24295	COG1832	CoA-binding protein
A176_RS24335	COG0315	cyclic pyranopterin monophosphate synthase activity
A176_RS24345	COG0492	ferredoxin-NADP+ reductase activity
A176_RS24355	COG2003	Belongs to the UPF0758 family
A176_RS24365	COG0514	ATP-dependent DNA helicase (RecQ)
A176_RS24365	COG0514	ATP-dependent DNA helicase (RecQ)
A176_RS24385	COG1088	dTDP-glucose 4,6-dehydratase activity
A176_RS24415	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
A176_RS24450	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A176_RS24460	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
A176_RS24465	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A176_RS24470	COG0515	serine threonine protein kinase
A176_RS24490	COG1100	Small GTP-binding protein
A176_RS24525	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A176_RS24550	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A176_RS24555	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A176_RS24560	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A176_RS24565	COG1619	proteins homologs of microcin C7 resistance protein MccF
A176_RS24570	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A176_RS24570	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A176_RS24585	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
A176_RS24620	COG4974	Belongs to the 'phage' integrase family
A176_RS24755	COG1570	exodeoxyribonuclease VII activity
A176_RS24765	COG3335	DDE superfamily endonuclease
A176_RS24810	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A176_RS24815	COG1205	dead DEAH box helicase
A176_RS24815	COG1111	helicase
A176_RS24890	COG1335	isochorismatase
A176_RS24985	COG0737	Belongs to the 5'-nucleotidase family
A176_RS24985	COG1525	nuclease
A176_RS24985	COG4085	toxin activity
A176_RS25020	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
A176_RS25060	COG2814	Major facilitator Superfamily
A176_RS25080	COG2814	Major facilitator Superfamily
A176_RS25085	COG0583	DNA-binding transcription factor activity
A176_RS25100	COG4977	sequence-specific DNA binding
A176_RS25110	COG1733	regulation of RNA biosynthetic process
A176_RS25155	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A176_RS25215	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A176_RS25220	COG0583	DNA-binding transcription factor activity
A176_RS25250	COG0667	Aldo Keto reductase
A176_RS25255	COG0583	DNA-binding transcription factor activity
A176_RS25290	COG0500	methyltransferase
A176_RS25300	COG2010	Cytochrome c
A176_RS25310	COG0318	PFAM AMP-dependent synthetase and ligase
A176_RS25345	COG0577	efflux transmembrane transporter activity
A176_RS25345	COG1136	(ABC) transporter
A176_RS25415	COG0583	DNA-binding transcription factor activity
A176_RS25420	COG0823	Involved in the tonB-independent uptake of proteins
A176_RS25420	COG1506	peptidase
A176_RS25440	COG2205	protein histidine kinase activity
A176_RS25595	COG1309	transcriptional regulator
A176_RS25600	COG0277	FAD linked oxidase domain protein
A176_RS25605	COG2937	Belongs to the GPAT DAPAT family
A176_RS25620	COG1858	cytochrome C peroxidase
A176_RS25660	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A176_RS25665	COG2814	Major facilitator Superfamily
A176_RS25670	COG0583	DNA-binding transcription factor activity
A176_RS25700	COG0477	Major facilitator Superfamily
A176_RS25740	COG2814	Major facilitator Superfamily
A176_RS25755	COG1802	Transcriptional regulator
A176_RS25760	COG0179	Fumarylacetoacetate (FAA) hydrolase
A176_RS25770	COG0726	polysaccharide deacetylase
A176_RS25855	COG3279	Response regulator of the LytR AlgR family
A176_RS25860	COG3275	phosphorelay sensor kinase activity
A176_RS25900	COG2267	carboxylic ester hydrolase activity
A176_RS25920	COG0531	amino acid
A176_RS25935	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A176_RS26020	COG2378	regulation of single-species biofilm formation
A176_RS26030	COG1278	Cold shock
A176_RS26090	COG0577	efflux transmembrane transporter activity
A176_RS26105	COG2264	protein methyltransferase activity
A176_RS26110	COG0842	Transport permease protein
A176_RS26155	COG0512	Glutamine amidotransferase of anthranilate synthase
A176_RS26165	COG1187	pseudouridine synthase activity
A176_RS26185	COG0628	permease
A176_RS26195	COG1238	metal cluster binding
A176_RS26205	COG0515	serine threonine protein kinase
A176_RS26205	COG2815	serine threonine protein kinase
A176_RS26210	COG0477	Major facilitator Superfamily
A176_RS26215	COG0583	DNA-binding transcription factor activity
A176_RS26225	COG0318	PFAM AMP-dependent synthetase and ligase
A176_RS26230	COG1045	serine acetyltransferase
A176_RS26240	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A176_RS26250	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
A176_RS26295	COG0450	alkyl hydroperoxide reductase
A176_RS26315	COG2264	protein methyltransferase activity
A176_RS26320	COG0531	amino acid
A176_RS26325	COG2814	Major facilitator Superfamily
A176_RS26340	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A176_RS26340	COG0723	plastoquinol--plastocyanin reductase activity
A176_RS26350	COG2202	Pas domain
A176_RS26350	COG2205	protein histidine kinase activity
A176_RS26385	COG1090	epimerase
A176_RS26390	COG0009	L-threonylcarbamoyladenylate synthase
A176_RS26420	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A176_RS26435	COG2967	ApaG domain
A176_RS26475	COG0318	PFAM AMP-dependent synthetase and ligase
A176_RS26480	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A176_RS26490	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
A176_RS26505	COG1690	Belongs to the RtcB family
A176_RS26515	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A176_RS26565	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A176_RS26595	COG1515	deoxyribonuclease V activity
A176_RS26675	COG1858	cytochrome C peroxidase
A176_RS26750	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
A176_RS26755	COG1666	GTP binding
A176_RS26765	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A176_RS26785	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A176_RS26790	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A176_RS26795	COG0211	Belongs to the bacterial ribosomal protein bL27 family
A176_RS26800	COG0261	This protein binds to 23S rRNA in the presence of protein L20
A176_RS26830	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A176_RS26835	COG0154	amidase activity
A176_RS26840	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A176_RS26860	COG0116	Belongs to the methyltransferase superfamily
A176_RS26860	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A176_RS26865	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
A176_RS26935	COG0606	chelatase, subunit chli
A176_RS26940	COG1252	NADH dehydrogenase
A176_RS26960	COG1546	Belongs to the CinA family
A176_RS26960	COG1058	Belongs to the CinA family
A176_RS26965	COG1183	phosphatidylcholine synthase activity
A176_RS26980	COG0776	regulation of translation
A176_RS26985	COG0739	heme binding
A176_RS26995	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A176_RS27000	COG0242	peptide deformylase activity
A176_RS27010	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A176_RS27025	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A176_RS27080	COG1028	Short-chain dehydrogenase reductase Sdr
A176_RS27130	COG1028	Short-chain dehydrogenase reductase Sdr
A176_RS27150	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A176_RS27150	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A176_RS27155	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
A176_RS27160	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A176_RS27175	COG1289	transmembrane transporter activity
A176_RS27185	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
A176_RS27200	COG2183	response to ionizing radiation
A176_RS27270	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A176_RS27275	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A176_RS27285	COG0405	Gamma-glutamyltransferase
A176_RS27335	COG0123	including yeast histone deacetylase and acetoin utilization protein
A176_RS27345	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
A176_RS27380	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A176_RS27385	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
A176_RS27415	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
A176_RS27430	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A176_RS27450	COG5002	protein histidine kinase activity
A176_RS27455	COG0745	RESPONSE REGULATOR receiver
A176_RS27470	COG3604	Transcriptional regulator
A176_RS27595	COG0815	Transfers the fatty acyl group on membrane lipoproteins
A176_RS27600	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
A176_RS27605	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A176_RS27615	COG3720	iron ion transport
A176_RS27625	COG4771	TonB-dependent receptor
A176_RS27645	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
A176_RS27675	COG0515	serine threonine protein kinase
A176_RS27680	COG0297	glycogen (starch) synthase activity
A176_RS27700	COG3275	phosphorelay sensor kinase activity
A176_RS27705	COG3279	Response regulator of the LytR AlgR family
A176_RS27725	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A176_RS27745	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A176_RS27775	COG3273	potassium ion transport
A176_RS27775	COG0471	metal ion transport
A176_RS27780	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
A176_RS27795	COG0436	Aminotransferase
A176_RS27805	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
A176_RS27810	COG0156	8-amino-7-oxononanoate synthase activity
A176_RS27815	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A176_RS27825	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
A176_RS27840	COG3852	Histidine kinase
A176_RS27890	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
A176_RS27895	COG1690	Belongs to the RtcB family
A176_RS27905	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
A176_RS27915	COG0308	aminopeptidase N
A176_RS27940	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
A176_RS27950	COG5000	phosphorelay sensor kinase activity
A176_RS28020	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
A176_RS28035	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
A176_RS28045	COG0544	peptidyl-prolyl cis-trans isomerase activity
A176_RS28065	COG0432	Pfam Uncharacterised protein family UPF0047
A176_RS28070	COG1376	ErfK ybiS ycfS ynhG family protein
A176_RS28085	COG2204	response regulator
A176_RS28090	COG3850	Histidine kinase
A176_RS28090	COG5002	protein histidine kinase activity
A176_RS28110	COG2815	serine threonine protein kinase
A176_RS28110	COG0515	serine threonine protein kinase
A176_RS28135	COG0693	protein deglycase activity
A176_RS28140	COG2151	metal-sulfur cluster biosynthetic enzyme
A176_RS28145	COG0822	iron-sulfur transferase activity
A176_RS28150	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A176_RS28155	COG0719	Fe-S assembly protein
A176_RS28160	COG0396	ATPase activity
A176_RS28165	COG0719	Fe-S assembly protein
A176_RS28225	COG0612	Peptidase, M16
A176_RS28235	COG2264	protein methyltransferase activity
A176_RS28265	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
A176_RS28275	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A176_RS28290	COG1714	RDD family
A176_RS28300	COG4191	Histidine kinase
A176_RS28305	COG2204	response regulator
A176_RS28315	COG1028	Short-chain dehydrogenase reductase Sdr
A176_RS28330	COG2264	protein methyltransferase activity
A176_RS28335	COG1127	ABC transporter
A176_RS28340	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A176_RS28380	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A176_RS28390	COG0439	Biotin carboxylase
A176_RS28395	COG0511	ligase activity, forming carbon-carbon bonds
A176_RS28395	COG5016	pyruvate
A176_RS28405	COG0730	response to heat
A176_RS28430	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
A176_RS28435	COG0564	pseudouridine synthase activity
A176_RS28445	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
A176_RS28455	COG0656	L-ascorbic acid biosynthetic process
A176_RS28460	COG1132	(ABC) transporter
A176_RS28470	COG0504	CTP synthase activity
A176_RS28475	COG2877	3-deoxy-8-phosphooctulonate synthase activity
A176_RS28480	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
A176_RS28485	COG0745	RESPONSE REGULATOR receiver
A176_RS28490	COG0071	Belongs to the small heat shock protein (HSP20) family
A176_RS28505	COG3830	Belongs to the UPF0237 family
A176_RS28505	COG0560	Phosphoserine phosphatase
A176_RS28510	COG0515	serine threonine protein kinase
A176_RS28510	COG2815	serine threonine protein kinase
A176_RS28530	COG0839	Belongs to the complex I subunit 6 family
A176_RS28535	COG0713	ATP synthesis coupled electron transport
A176_RS28550	COG1007	ATP synthesis coupled electron transport
A176_RS28565	COG4191	Histidine kinase
A176_RS28575	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A176_RS28585	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
A176_RS28590	COG2009	succinate dehydrogenase
A176_RS28595	COG0629	single-stranded DNA binding
A176_RS28600	COG2027	D-alanyl-D-alanine carboxypeptidase
A176_RS28605	COG1490	D-aminoacyl-tRNA deacylase activity
A176_RS28615	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A176_RS28620	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
A176_RS28640	COG1137	ATPase activity
A176_RS28655	COG1560	Kdo2-lipid A biosynthetic process
A176_RS28660	COG3724	N-succinylarginine dihydrolase activity
A176_RS28715	COG3795	YCII-related domain
A176_RS28730	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A176_RS28740	COG1368	sulfuric ester hydrolase activity
A176_RS28755	COG0463	Glycosyl transferase, family 2
A176_RS28755	COG1216	Glycosyl transferase, family 2
A176_RS28780	COG0438	transferase activity, transferring glycosyl groups
A176_RS28790	COG0297	glycogen (starch) synthase activity
A176_RS28810	COG0438	transferase activity, transferring glycosyl groups
A176_RS28820	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A176_RS28850	COG4968	Prepilin-type N-terminal cleavage methylation domain
A176_RS28865	COG5002	protein histidine kinase activity
A176_RS28885	COG0402	S-adenosylhomocysteine deaminase activity
A176_RS28935	COG2322	membrane
A176_RS28940	COG5002	protein histidine kinase activity
A176_RS28945	COG0784	Response regulator, receiver
A176_RS28950	COG4251	negative regulation of phosphorylation
A176_RS28960	COG1404	Belongs to the peptidase S8 family
A176_RS28965	COG1201	RNA secondary structure unwinding
A176_RS28970	COG0644	oxidoreductase
A176_RS28975	COG3842	ATPase activity
A176_RS29015	COG3023	N-Acetylmuramoyl-L-alanine amidase
A176_RS29075	COG1858	cytochrome C peroxidase
A176_RS29095	COG0527	aspartate kinase activity
A176_RS29095	COG0460	homoserine dehydrogenase
A176_RS29100	COG0626	cystathionine gamma-synthase activity
A176_RS29105	COG0626	cystathionine gamma-synthase activity
A176_RS29110	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A176_RS29115	COG2011	ABC-type metal ion transport system permease component
A176_RS29120	COG1464	Belongs to the NlpA lipoprotein family
A176_RS29155	COG0420	3'-5' exonuclease activity
A176_RS29180	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A176_RS29185	COG0363	glucosamine-6-phosphate deaminase activity
A176_RS29190	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
A176_RS29205	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A176_RS29235	COG1846	Transcriptional regulator
A176_RS29265	COG2204	response regulator
A176_RS29280	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A176_RS29285	COG2815	serine threonine protein kinase
A176_RS29285	COG0515	serine threonine protein kinase
A176_RS29290	COG1297	OPT oligopeptide transporter protein
A176_RS29300	COG0515	serine threonine protein kinase
A176_RS29310	COG4191	Histidine kinase
A176_RS29335	COG4221	oxidoreductase activity
A176_RS29355	COG0662	Cupin 2, conserved barrel domain protein
A176_RS29365	COG3844	kynureninase activity
A176_RS29370	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A176_RS29395	COG0174	glutamine synthetase
A176_RS29420	COG2204	response regulator
A176_RS29470	COG1233	COG1233 Phytoene dehydrogenase and related
A176_RS29475	COG1562	ergosterol biosynthetic process
A176_RS29485	COG0142	geranyltranstransferase activity
A176_RS29495	COG1090	epimerase
A176_RS29515	COG1408	metallophosphoesterase
A176_RS29520	COG1309	transcriptional regulator
A176_RS29535	COG2819	hydrolase of the alpha beta superfamily
A176_RS29545	COG2815	serine threonine protein kinase
A176_RS29545	COG0515	serine threonine protein kinase
A176_RS29580	COG0625	glutathione transferase activity
A176_RS29620	COG0596	Alpha beta hydrolase
A176_RS29635	COG0783	Belongs to the Dps family
A176_RS29645	COG0625	glutathione transferase activity
A176_RS29650	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
A176_RS29655	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
A176_RS29675	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A176_RS29725	COG0443	Heat shock 70 kDa protein
A176_RS29740	COG1360	Flagellar Motor Protein
A176_RS29750	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A176_RS29760	COG3383	formate dehydrogenase (NAD+) activity
A176_RS29770	COG0604	alcohol dehydrogenase
A176_RS29815	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A176_RS29830	COG0829	nickel cation binding
A176_RS29835	COG0832	Belongs to the urease beta subunit family
A176_RS29835	COG0831	urea catabolic process
A176_RS29840	COG0804	urea catabolic process
A176_RS29845	COG0830	nickel cation binding
A176_RS29850	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
A176_RS29910	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
A176_RS29930	COG1028	Short-chain dehydrogenase reductase Sdr
A176_RS29985	COG0679	Auxin Efflux Carrier
A176_RS29990	COG1404	Belongs to the peptidase S8 family
A176_RS29995	COG1404	Belongs to the peptidase S8 family
A176_RS30030	COG0784	Response regulator, receiver
A176_RS30035	COG4251	negative regulation of phosphorylation
A176_RS30085	COG1960	acyl-CoA dehydrogenase activity
A176_RS30115	COG0612	Peptidase, M16
A176_RS30140	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A176_RS30145	COG0583	DNA-binding transcription factor activity
A176_RS30150	COG1574	metal-dependent hydrolase with the TIM-barrel fold
A176_RS30160	COG0438	transferase activity, transferring glycosyl groups
A176_RS30170	COG0330	HflC and HflK could
A176_RS30200	COG0300	oxidoreductase activity
A176_RS30210	COG3842	ATPase activity
A176_RS30215	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
A176_RS30220	COG1840	ABC-type Fe3 transport system, periplasmic component
A176_RS30230	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A176_RS30260	COG0745	RESPONSE REGULATOR receiver
A176_RS30270	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
A176_RS30315	COG0484	heat shock protein binding
A176_RS30325	COG1132	(ABC) transporter
A176_RS30380	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A176_RS30405	COG0745	RESPONSE REGULATOR receiver
A176_RS30410	COG3483	tryptophan 2,3-dioxygenase activity
A176_RS30425	COG2197	response regulator
A176_RS30430	COG0745	RESPONSE REGULATOR receiver
A176_RS30435	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
A176_RS30440	COG2815	serine threonine protein kinase
A176_RS30440	COG0515	serine threonine protein kinase
A176_RS30480	COG3437	response regulator, receiver
A176_RS30485	COG2201	protein-glutamate methylesterase activity
A176_RS30490	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
A176_RS30505	COG0745	RESPONSE REGULATOR receiver
A176_RS30510	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
A176_RS30525	COG2205	protein histidine kinase activity
A176_RS30535	COG2031	fatty acid transporter
A176_RS30560	COG4977	sequence-specific DNA binding
A176_RS30570	COG0702	epimerase
A176_RS30625	COG2124	cytochrome p450
A176_RS30635	COG0583	DNA-binding transcription factor activity
A176_RS30650	COG3795	YCII-related domain
A176_RS30655	COG0667	Aldo Keto reductase
A176_RS30685	COG1278	Cold shock
A176_RS30720	COG1309	transcriptional regulator
A176_RS30730	COG1234	tRNA 3'-trailer cleavage
A176_RS30750	COG1574	metal-dependent hydrolase with the TIM-barrel fold
A176_RS30785	COG1764	response to oxidative stress
A176_RS30790	COG1846	Transcriptional regulator
A176_RS30840	COG5002	protein histidine kinase activity
A176_RS30860	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
A176_RS30880	COG1192	Involved in chromosome partitioning
A176_RS30910	COG1126	abc transporter atp-binding protein
A176_RS30915	COG4191	Histidine kinase
A176_RS30925	COG1309	transcriptional regulator
A176_RS30955	COG0488	(ABC) transporter
A176_RS30980	COG1028	Short-chain dehydrogenase reductase Sdr
A176_RS30985	COG2376	Dihydroxyacetone kinase
A176_RS30995	COG3265	gluconokinase activity
A176_RS31000	COG1793	dna ligase
A176_RS31025	COG4191	Histidine kinase
A176_RS31030	COG0110	maltose O-acetyltransferase activity
A176_RS31040	COG0671	phosphoesterase, PA-phosphatase related
A176_RS31045	COG0848	biopolymer transport protein
A176_RS31100	COG0109	protoheme IX farnesyltransferase activity
A176_RS31100	COG1612	heme a metabolic process
A176_RS31105	COG1174	glycine betaine transport
A176_RS31110	COG0517	IMP dehydrogenase activity
A176_RS31110	COG1125	glycine betaine transport
A176_RS31125	COG0668	transmembrane transport
A176_RS31130	COG1819	glycosyl
A176_RS31180	COG2373	Large extracellular alpha-helical protein
A176_RS31210	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A176_RS31235	COG5002	protein histidine kinase activity
A176_RS31240	COG1525	nuclease
A176_RS31275	COG3409	Peptidoglycan-binding domain 1 protein
A176_RS31275	COG5632	N-Acetylmuramoyl-L-alanine amidase
A176_RS31285	COG0501	Belongs to the peptidase M48B family
A176_RS31300	COG1876	peptidase activity
A176_RS31320	COG0488	(ABC) transporter
A176_RS31350	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A176_RS31365	COG1131	(ABC) transporter
A176_RS31370	COG0842	Transport permease protein
A176_RS31395	COG0625	glutathione transferase activity
A176_RS31425	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
A176_RS31445	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A176_RS31455	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A176_RS31455	COG0551	DNA topoisomerase type I activity
A176_RS31480	COG0436	Aminotransferase
A176_RS31510	COG2815	serine threonine protein kinase
A176_RS31510	COG0515	serine threonine protein kinase
A176_RS31515	COG2197	response regulator
A176_RS31535	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
A176_RS31535	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
A176_RS31545	COG4771	TonB-dependent receptor
A176_RS31570	COG0346	lactoylglutathione lyase activity
A176_RS31575	COG2816	NAD+ diphosphatase activity
A176_RS31580	COG0602	queuosine metabolic process
A176_RS31620	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A176_RS31625	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A176_RS31630	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
A176_RS31655	COG0006	proline dipeptidase activity
A176_RS31665	COG4191	Histidine kinase
A176_RS31670	COG2204	response regulator
A176_RS31675	COG4191	Histidine kinase
A176_RS31700	COG0667	Aldo Keto reductase
A176_RS31750	COG0492	ferredoxin-NADP+ reductase activity
A176_RS31780	COG2258	MOSC domain
A176_RS31830	COG1960	acyl-CoA dehydrogenase activity
A176_RS31855	COG3942	CHAP domain
A176_RS31855	COG1388	LysM domain
A176_RS31890	COG1408	metallophosphoesterase
A176_RS31930	COG0012	GTP binding
A176_RS31935	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A176_RS31940	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A176_RS31945	COG0356	it plays a direct role in the translocation of protons across the membrane
A176_RS31960	COG1881	PFAM PEBP family protein
A176_RS31965	COG4191	Histidine kinase
A176_RS31975	COG0515	serine threonine protein kinase
A176_RS31980	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
A176_RS31990	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
A176_RS32085	COG0582	viral genome integration into host DNA
A176_RS32105	COG2239	Acts as a magnesium transporter
A176_RS32125	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
A176_RS32140	COG2267	carboxylic ester hydrolase activity
A176_RS32145	COG3275	phosphorelay sensor kinase activity
A176_RS32150	COG3279	Response regulator of the LytR AlgR family
A176_RS32165	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
A176_RS32170	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
A176_RS32175	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
A176_RS32220	COG4970	Tfp pilus assembly protein FimT
A176_RS32225	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A176_RS32260	COG0189	ligase activity
A176_RS32290	COG0823	Involved in the tonB-independent uptake of proteins
A176_RS32315	COG3158	transport of potassium into the cell
A176_RS32320	COG5002	protein histidine kinase activity
A176_RS32345	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A176_RS32345	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A176_RS32360	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A176_RS32395	COG0586	Pfam SNARE associated Golgi protein
A176_RS32425	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A176_RS32450	COG4948	Mandelate Racemase Muconate Lactonizing
A176_RS32460	COG2197	response regulator
A176_RS32490	COG4999	Histidine kinase
A176_RS32490	COG3850	Histidine kinase
A176_RS32490	COG2205	protein histidine kinase activity
A176_RS32490	COG3437	response regulator, receiver
A176_RS32495	COG0667	Aldo Keto reductase
A176_RS32500	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A176_RS32525	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A176_RS32530	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A176_RS32545	COG0477	Major facilitator Superfamily
A176_RS32565	COG2181	nitrate reductase activity
A176_RS32565	COG0247	lactate metabolic process
A176_RS32595	COG1690	Belongs to the RtcB family
A176_RS32600	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
A176_RS32605	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A176_RS32645	COG3177	Filamentation induced by cAMP protein fic
A176_RS32685	COG1396	sequence-specific DNA binding
A176_RS32690	COG0475	glutathione-regulated potassium exporter activity
A176_RS32695	COG0745	RESPONSE REGULATOR receiver
A176_RS32715	COG4067	protein conserved in archaea
A176_RS32715	COG0189	ligase activity
A176_RS32730	COG1127	ABC transporter
A176_RS32735	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A176_RS32750	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A176_RS32755	COG2205	protein histidine kinase activity
A176_RS32755	COG0784	Response regulator, receiver
A176_RS32760	COG4335	DNA alkylation repair
A176_RS32835	COG0784	Response regulator, receiver
A176_RS32835	COG2198	Histidine kinase
A176_RS32835	COG2205	protein histidine kinase activity
A176_RS32845	COG0840	transmembrane signaling receptor activity
A176_RS32875	COG3220	belongs to the UPF0276 family
A176_RS32915	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A176_RS32920	COG1309	transcriptional regulator
A176_RS32930	COG1522	sequence-specific DNA binding
A176_RS32935	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A176_RS32940	COG1028	Short-chain dehydrogenase reductase Sdr
A176_RS32945	COG0741	lytic transglycosylase activity
A176_RS32945	COG1196	nuclear chromosome segregation
A176_RS32945	COG0739	heme binding
A176_RS32965	COG1404	Belongs to the peptidase S8 family
A176_RS32970	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
A176_RS33000	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A176_RS33005	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A176_RS33010	COG5002	protein histidine kinase activity
A176_RS33080	COG0446	pyridine nucleotide-disulphide oxidoreductase
A176_RS33085	COG2204	response regulator
A176_RS33090	COG3453	Protein conserved in bacteria
A176_RS33090	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A176_RS33095	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A176_RS33105	COG2205	protein histidine kinase activity
A176_RS33120	COG2759	Belongs to the formate--tetrahydrofolate ligase family
A176_RS33155	COG5002	protein histidine kinase activity
A176_RS33160	COG2205	protein histidine kinase activity
A176_RS33165	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
A176_RS33175	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
A176_RS33200	COG0277	FAD linked oxidase domain protein
A176_RS33210	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
A176_RS33240	COG5006	permease, DMT superfamily
A176_RS33250	COG5000	phosphorelay sensor kinase activity
A176_RS33270	COG0420	3'-5' exonuclease activity
A176_RS33275	COG4717	serine-type aminopeptidase activity
A176_RS33310	COG0515	serine threonine protein kinase
A176_RS33365	COG1073	alpha beta
A176_RS33395	COG0815	Transfers the fatty acyl group on membrane lipoproteins
A176_RS33415	COG0038	chloride channel
A176_RS33430	COG2843	Capsule synthesis protein
A176_RS33440	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A176_RS33440	COG0543	2 iron, 2 sulfur cluster binding
A176_RS33455	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
A176_RS33465	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A176_RS33465	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
A176_RS33490	COG0515	serine threonine protein kinase
A176_RS33495	COG2204	response regulator
A176_RS33525	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A176_RS33540	COG0577	efflux transmembrane transporter activity
A176_RS33545	COG0577	efflux transmembrane transporter activity
A176_RS33545	COG1136	(ABC) transporter
A176_RS33555	COG0477	Major facilitator Superfamily
A176_RS33595	COG3550	peptidyl-serine autophosphorylation
A176_RS33615	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A176_RS33620	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A176_RS33630	COG0625	glutathione transferase activity
A176_RS33645	COG1960	acyl-CoA dehydrogenase activity
A176_RS33650	COG1028	Short-chain dehydrogenase reductase Sdr
A176_RS33660	COG2814	Major facilitator Superfamily
A176_RS33670	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A176_RS33685	COG1028	Short-chain dehydrogenase reductase Sdr
A176_RS33695	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
A176_RS33695	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A176_RS33700	COG0402	S-adenosylhomocysteine deaminase activity
A176_RS33725	COG2815	serine threonine protein kinase
A176_RS33725	COG0515	serine threonine protein kinase
A176_RS33745	COG1690	Belongs to the RtcB family
A176_RS33765	COG2205	protein histidine kinase activity
A176_RS33795	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
A176_RS33870	COG3387	PFAM Glycoside hydrolase 15-related
A176_RS33940	COG0557	exoribonuclease II activity
A176_RS33975	COG0515	serine threonine protein kinase
A176_RS33980	COG0189	ligase activity
A176_RS33990	COG3550	peptidyl-serine autophosphorylation
A176_RS33995	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
A176_RS34020	COG2259	Doxx family
A176_RS34030	COG2814	Major facilitator Superfamily
A176_RS34035	COG2267	carboxylic ester hydrolase activity
A176_RS34090	COG0300	oxidoreductase activity
A176_RS34095	COG0230	Belongs to the bacterial ribosomal protein bL34 family
A176_RS34100	COG0594	ribonuclease P activity
A176_RS34105	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
A176_RS34110	COG0706	membrane insertase activity
A176_RS34125	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
A176_RS34145	COG0616	signal peptide processing
A176_RS34150	COG0667	Aldo Keto reductase
A176_RS34155	COG0612	Peptidase, M16
A176_RS34170	COG2814	Major facilitator Superfamily
A176_RS34175	COG0445	tRNA wobble uridine modification
A176_RS34180	COG0357	Ribosomal RNA small subunit methyltransferase G
A176_RS34195	COG1192	Involved in chromosome partitioning
A176_RS34200	COG1475	DNA binding
A176_RS34220	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
A176_RS34255	COG0038	chloride channel
A176_RS34360	COG1045	serine acetyltransferase
A176_RS34380	COG5002	protein histidine kinase activity
A176_RS34385	COG2239	Acts as a magnesium transporter
A176_RS34405	COG5002	protein histidine kinase activity
A176_RS34430	COG2304	oxidoreductase activity
A176_RS34450	COG0745	RESPONSE REGULATOR receiver
A176_RS34470	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A176_RS34480	COG0303	'Molybdopterin
A176_RS34485	COG0746	molybdenum cofactor guanylyltransferase activity
A176_RS34505	COG2814	Major facilitator Superfamily
A176_RS34525	COG3387	PFAM Glycoside hydrolase 15-related
A176_RS34530	COG0506	proline dehydrogenase activity
A176_RS34555	COG3483	tryptophan 2,3-dioxygenase activity
A176_RS34630	COG1388	LysM domain
A176_RS34630	COG3942	CHAP domain
A176_RS34665	COG0516	GMP reductase activity
A176_RS34665	COG0517	IMP dehydrogenase activity
A176_RS34670	COG0003	Pfam Anion-transporting ATPase
A176_RS34680	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A176_RS34705	COG2815	serine threonine protein kinase
A176_RS34705	COG0515	serine threonine protein kinase
A176_RS34725	COG5001	Diguanylate cyclase
A176_RS34735	COG0745	RESPONSE REGULATOR receiver
A176_RS34740	COG5002	protein histidine kinase activity
A176_RS34770	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A176_RS34785	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A176_RS34800	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A176_RS34830	COG0242	peptide deformylase activity
A176_RS34925	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
A176_RS34945	COG2755	lipolytic protein G-D-S-L family
A176_RS34945	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
A176_RS34955	COG1064	alcohol dehydrogenase
A176_RS35000	COG1309	transcriptional regulator
A176_RS35005	COG2267	carboxylic ester hydrolase activity
A176_RS35020	COG0583	DNA-binding transcription factor activity
A176_RS35025	COG1960	acyl-CoA dehydrogenase activity
A176_RS35055	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
A176_RS35080	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A176_RS35080	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A176_RS35095	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A176_RS35125	COG1653	transport
A176_RS35155	COG0515	serine threonine protein kinase
A176_RS35155	COG2815	serine threonine protein kinase
A176_RS35210	COG0515	serine threonine protein kinase
A176_RS35215	COG0714	Associated with various cellular activities
A176_RS35225	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A176_RS35230	COG4279	zinc finger
A176_RS35265	COG0667	Aldo Keto reductase
A176_RS35280	COG0515	serine threonine protein kinase
A176_RS35300	COG1203	CRISPR-associated helicase, Cas3
A176_RS35310	COG1857	crispr-associated protein
A176_RS35320	COG1468	defense response to virus
A176_RS35320	COG1518	maintenance of DNA repeat elements
A176_RS35325	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
A176_RS35340	COG0702	epimerase
A176_RS35350	COG3932	Exopolysaccharide synthesis, ExoD
A176_RS35355	COG0515	serine threonine protein kinase
A176_RS35380	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A176_RS35415	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A176_RS35420	COG0596	Alpha beta hydrolase
A176_RS35455	COG1127	ABC transporter
A176_RS35460	COG3842	ATPase activity
A176_RS35560	COG2205	protein histidine kinase activity
A176_RS35560	COG0784	Response regulator, receiver
A176_RS35595	COG1028	Short-chain dehydrogenase reductase Sdr
A176_RS35605	COG1056	cytidyltransferase-related domain
A176_RS35605	COG1051	belongs to the nudix hydrolase family
A176_RS35630	COG1309	transcriptional regulator
A176_RS35635	COG2311	Membrane
A176_RS35640	COG0438	transferase activity, transferring glycosyl groups
A176_RS35645	COG0438	transferase activity, transferring glycosyl groups
A176_RS35675	COG5002	protein histidine kinase activity
A176_RS35690	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A176_RS35735	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A176_RS35745	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A176_RS35755	COG1560	Kdo2-lipid A biosynthetic process
A176_RS35760	COG0308	aminopeptidase N
A176_RS35765	COG1024	Enoyl-CoA hydratase
A176_RS35770	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A176_RS35795	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
A176_RS35800	COG0745	RESPONSE REGULATOR receiver
A176_RS35805	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
A176_RS35810	COG0318	PFAM AMP-dependent synthetase and ligase
A176_RS35820	COG1136	(ABC) transporter
A176_RS35820	COG0577	efflux transmembrane transporter activity
A176_RS35825	COG1136	(ABC) transporter
A176_RS35830	COG0577	efflux transmembrane transporter activity
A176_RS35835	COG1136	(ABC) transporter
A176_RS35835	COG0577	efflux transmembrane transporter activity
A176_RS35845	COG3852	Histidine kinase
A176_RS35860	COG0768	penicillin binding
A176_RS35865	COG1058	Belongs to the CinA family
A176_RS35865	COG1546	Belongs to the CinA family
A176_RS35910	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A176_RS35950	COG2205	protein histidine kinase activity
A176_RS35975	COG0534	Mate efflux family protein
A176_RS35995	COG4149	molybdate abc transporter
A176_RS36020	COG0545	Peptidyl-prolyl cis-trans isomerase
A176_RS36025	COG0412	Dienelactone hydrolase
A176_RS36060	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
A176_RS36110	COG0386	Belongs to the glutathione peroxidase family
A176_RS36145	COG2226	methyltransferase
A176_RS36155	COG2815	serine threonine protein kinase
A176_RS36155	COG0515	serine threonine protein kinase
A176_RS36175	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A176_RS36190	COG0577	efflux transmembrane transporter activity
A176_RS36190	COG1136	(ABC) transporter
A176_RS36245	COG1966	Carbon starvation protein
A176_RS36250	COG2879	small protein
A176_RS36255	COG0217	transcriptional regulatory protein
A176_RS36265	COG1472	Belongs to the glycosyl hydrolase 3 family
A176_RS36270	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A176_RS36285	COG2270	Major facilitator Superfamily
A176_RS36360	COG0667	Aldo Keto reductase
A176_RS36370	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A176_RS36370	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A176_RS36380	COG2267	carboxylic ester hydrolase activity
A176_RS36390	COG1360	Flagellar Motor Protein
A176_RS36395	COG0435	Glutathione S-transferase
A176_RS36410	COG2204	response regulator
A176_RS36430	COG5002	protein histidine kinase activity
A176_RS36450	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A176_RS36455	COG0443	Heat shock 70 kDa protein
A176_RS36470	COG0534	Mate efflux family protein
A176_RS36490	COG1203	CRISPR-associated helicase, Cas3
A176_RS36515	COG1518	maintenance of DNA repeat elements
A176_RS36565	COG0745	RESPONSE REGULATOR receiver
A176_RS36575	COG2205	protein histidine kinase activity
A176_RS36585	COG0745	RESPONSE REGULATOR receiver
A176_RS36610	COG5002	protein histidine kinase activity
A176_RS36650	COG1024	Enoyl-CoA hydratase
A176_RS36670	COG1960	acyl-CoA dehydrogenase activity
A176_RS36675	COG1960	acyl-CoA dehydrogenase activity
A176_RS36680	COG0183	Belongs to the thiolase family
A176_RS36690	COG2010	Cytochrome c
A176_RS36715	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
A176_RS36745	COG1408	metallophosphoesterase
A176_RS36750	COG5002	protein histidine kinase activity
A176_RS36750	COG2205	protein histidine kinase activity
A176_RS36750	COG0784	Response regulator, receiver
A176_RS36785	COG0745	RESPONSE REGULATOR receiver
A176_RS36790	COG2198	Histidine kinase
A176_RS36790	COG0643	Histidine kinase
A176_RS36795	COG0835	chemotaxis
A176_RS36800	COG0840	transmembrane signaling receptor activity
A176_RS36810	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
A176_RS36815	COG2201	protein-glutamate methylesterase activity
A176_RS36830	COG0745	RESPONSE REGULATOR receiver
A176_RS36835	COG5002	protein histidine kinase activity
A176_RS36845	COG5002	protein histidine kinase activity
A176_RS36850	COG2201	protein-glutamate methylesterase activity
A176_RS36860	COG0840	transmembrane signaling receptor activity
A176_RS36870	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
A176_RS36875	COG0835	chemotaxis
A176_RS36910	COG0840	transmembrane signaling receptor activity
A176_RS36955	COG3118	belongs to the thioredoxin family
A176_RS36970	COG2949	membrane
A176_RS36975	COG0835	chemotaxis
A176_RS36975	COG0784	Response regulator, receiver
A176_RS36980	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A176_RS36990	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
A176_RS37000	COG0355	proton-transporting ATP synthase activity, rotational mechanism
A176_RS37005	COG2346	COG2346, Truncated hemoglobins
A176_RS37015	COG1959	2 iron, 2 sulfur cluster binding
A176_RS37040	COG1271	oxidase subunit
A176_RS37055	COG4771	TonB-dependent receptor
A176_RS37065	COG1028	Short-chain dehydrogenase reductase Sdr
A176_RS37070	COG0166	Belongs to the GPI family
A176_RS37090	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
A176_RS37120	COG3047	cAMP biosynthetic process
A176_RS37120	COG2885	chlorophyll binding
A176_RS37135	COG1160	GTP binding
A176_RS37185	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A176_RS37200	COG1028	Short-chain dehydrogenase reductase Sdr
A176_RS37225	COG3243	poly(R)-hydroxyalkanoic acid synthase
A176_RS37240	COG4221	oxidoreductase activity
A176_RS37245	COG0720	synthase
A176_RS37270	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A176_RS37270	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A176_RS37280	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A176_RS37345	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
A176_RS37345	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A176_RS37360	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A176_RS37365	COG5002	protein histidine kinase activity
A176_RS37430	COG3568	Endonuclease Exonuclease Phosphatase
A176_RS37430	COG1555	photosystem II stabilization
A176_RS37455	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
A176_RS37470	COG4555	ABC transporter
A176_RS37475	COG1668	transmembrane transport
A176_RS37495	COG0308	aminopeptidase N
A176_RS37525	COG1858	cytochrome C peroxidase
A176_RS37540	COG3594	Acyltransferase
A176_RS37650	COG5507	3-demethylubiquinone-9 3-methyltransferase
A176_RS37680	COG0515	serine threonine protein kinase