locus-tag	class	description
I5Q59_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I5Q59_RS00015	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
I5Q59_RS00045	COG2814	Major facilitator Superfamily
I5Q59_RS00055	COG2259	Doxx family
I5Q59_RS00065	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I5Q59_RS00070	COG3550	peptidyl-serine autophosphorylation
I5Q59_RS00080	COG0189	ligase activity
I5Q59_RS00085	COG0515	serine threonine protein kinase
I5Q59_RS00120	COG0515	serine threonine protein kinase
I5Q59_RS00125	COG0557	exoribonuclease II activity
I5Q59_RS00180	COG1802	Transcriptional regulator
I5Q59_RS00190	COG2070	2-Nitropropane dioxygenase
I5Q59_RS00190	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I5Q59_RS00200	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I5Q59_RS00205	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I5Q59_RS00210	COG3425	synthase
I5Q59_RS00215	COG1024	Enoyl-CoA hydratase
I5Q59_RS00220	COG1024	Enoyl-CoA hydratase
I5Q59_RS00230	COG0300	oxidoreductase activity
I5Q59_RS00230	COG0318	PFAM AMP-dependent synthetase and ligase
I5Q59_RS00230	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I5Q59_RS00230	COG1028	Short-chain dehydrogenase reductase Sdr
I5Q59_RS00230	COG3321	synthase
I5Q59_RS00235	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I5Q59_RS00235	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I5Q59_RS00235	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I5Q59_RS00235	COG3321	synthase
I5Q59_RS00235	COG1028	Short-chain dehydrogenase reductase Sdr
I5Q59_RS00240	COG4221	oxidoreductase activity
I5Q59_RS00240	COG3321	synthase
I5Q59_RS00240	COG1028	Short-chain dehydrogenase reductase Sdr
I5Q59_RS00240	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I5Q59_RS00245	COG3321	synthase
I5Q59_RS00245	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I5Q59_RS00245	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I5Q59_RS00245	COG1028	Short-chain dehydrogenase reductase Sdr
I5Q59_RS00245	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I5Q59_RS00260	COG1024	Enoyl-CoA hydratase
I5Q59_RS00260	COG1250	3-hydroxyacyl-CoA dehydrogenase
I5Q59_RS00265	COG2124	cytochrome p450
I5Q59_RS00305	COG1063	alcohol dehydrogenase
I5Q59_RS00310	COG3387	PFAM Glycoside hydrolase 15-related
I5Q59_RS00385	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I5Q59_RS00415	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
I5Q59_RS00425	COG1690	Belongs to the RtcB family
I5Q59_RS00450	COG0515	serine threonine protein kinase
I5Q59_RS00450	COG2815	serine threonine protein kinase
I5Q59_RS00475	COG0402	S-adenosylhomocysteine deaminase activity
I5Q59_RS00480	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
I5Q59_RS00490	COG1028	Short-chain dehydrogenase reductase Sdr
I5Q59_RS00505	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I5Q59_RS00535	COG2814	Major facilitator Superfamily
I5Q59_RS00540	COG3491	Belongs to the iron ascorbate-dependent oxidoreductase family
I5Q59_RS00545	COG0625	glutathione transferase activity
I5Q59_RS00580	COG4106	trans-aconitate 2-methyltransferase activity
I5Q59_RS00585	COG3550	peptidyl-serine autophosphorylation
I5Q59_RS00615	COG3173	Aminoglycoside phosphotransferase
I5Q59_RS00620	COG0477	Major facilitator Superfamily
I5Q59_RS00630	COG1136	(ABC) transporter
I5Q59_RS00630	COG0577	efflux transmembrane transporter activity
I5Q59_RS00635	COG0577	efflux transmembrane transporter activity
I5Q59_RS00680	COG2204	response regulator
I5Q59_RS00685	COG2815	serine threonine protein kinase
I5Q59_RS00685	COG0515	serine threonine protein kinase
I5Q59_RS00710	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
I5Q59_RS00710	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I5Q59_RS00720	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I5Q59_RS00730	COG2843	Capsule synthesis protein
I5Q59_RS00750	COG0038	chloride channel
I5Q59_RS00770	COG0815	Transfers the fatty acyl group on membrane lipoproteins
I5Q59_RS00780	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
I5Q59_RS00785	COG1073	alpha beta
I5Q59_RS00830	COG4717	serine-type aminopeptidase activity
I5Q59_RS00835	COG0420	3'-5' exonuclease activity
I5Q59_RS00855	COG5000	phosphorelay sensor kinase activity
I5Q59_RS00865	COG5006	permease, DMT superfamily
I5Q59_RS00890	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I5Q59_RS00895	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
I5Q59_RS00920	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
I5Q59_RS00925	COG2205	protein histidine kinase activity
I5Q59_RS00930	COG5002	protein histidine kinase activity
I5Q59_RS00960	COG0840	transmembrane signaling receptor activity
I5Q59_RS00965	COG2759	Belongs to the formate--tetrahydrofolate ligase family
I5Q59_RS00975	COG2205	protein histidine kinase activity
I5Q59_RS00985	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I5Q59_RS00990	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I5Q59_RS00995	COG2204	response regulator
I5Q59_RS01000	COG0446	pyridine nucleotide-disulphide oxidoreductase
I5Q59_RS01065	COG2304	oxidoreductase activity
I5Q59_RS01075	COG3850	Histidine kinase
I5Q59_RS01075	COG3437	response regulator, receiver
I5Q59_RS01075	COG2205	protein histidine kinase activity
I5Q59_RS01075	COG4999	Histidine kinase
I5Q59_RS01080	COG5002	protein histidine kinase activity
I5Q59_RS01085	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I5Q59_RS01090	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I5Q59_RS01095	COG0697	spore germination
I5Q59_RS01115	COG2226	methyltransferase
I5Q59_RS01120	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I5Q59_RS01125	COG1404	Belongs to the peptidase S8 family
I5Q59_RS01145	COG0741	lytic transglycosylase activity
I5Q59_RS01150	COG1028	Short-chain dehydrogenase reductase Sdr
I5Q59_RS01155	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I5Q59_RS01160	COG1522	sequence-specific DNA binding
I5Q59_RS01165	COG1309	transcriptional regulator
I5Q59_RS01170	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I5Q59_RS01175	COG0318	PFAM AMP-dependent synthetase and ligase
I5Q59_RS01215	COG0318	PFAM AMP-dependent synthetase and ligase
I5Q59_RS01220	COG0840	transmembrane signaling receptor activity
I5Q59_RS01230	COG5002	protein histidine kinase activity
I5Q59_RS01305	COG4335	DNA alkylation repair
I5Q59_RS01310	COG2205	protein histidine kinase activity
I5Q59_RS01310	COG0784	Response regulator, receiver
I5Q59_RS01315	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I5Q59_RS01330	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I5Q59_RS01335	COG1127	ABC transporter
I5Q59_RS01380	COG0745	RESPONSE REGULATOR receiver
I5Q59_RS01385	COG0475	glutathione-regulated potassium exporter activity
I5Q59_RS01390	COG1396	sequence-specific DNA binding
I5Q59_RS01470	COG1051	belongs to the nudix hydrolase family
I5Q59_RS01475	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I5Q59_RS01480	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I5Q59_RS01485	COG1690	Belongs to the RtcB family
I5Q59_RS01515	COG2181	nitrate reductase activity
I5Q59_RS01515	COG0247	lactate metabolic process
I5Q59_RS01545	COG0477	Major facilitator Superfamily
I5Q59_RS01560	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I5Q59_RS01565	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I5Q59_RS01600	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I5Q59_RS01605	COG0667	Aldo Keto reductase
I5Q59_RS01655	COG4948	Mandelate Racemase Muconate Lactonizing
I5Q59_RS01710	COG0586	Pfam SNARE associated Golgi protein
I5Q59_RS01745	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I5Q59_RS01760	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I5Q59_RS01760	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I5Q59_RS01765	COG0745	RESPONSE REGULATOR receiver
I5Q59_RS01785	COG2205	protein histidine kinase activity
I5Q59_RS01785	COG0784	Response regulator, receiver
I5Q59_RS01790	COG3158	transport of potassium into the cell
I5Q59_RS01815	COG0823	Involved in the tonB-independent uptake of proteins
I5Q59_RS01820	COG5002	protein histidine kinase activity
I5Q59_RS01845	COG0189	ligase activity
I5Q59_RS01850	COG2204	response regulator
I5Q59_RS01880	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I5Q59_RS01930	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I5Q59_RS01935	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I5Q59_RS01940	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I5Q59_RS01975	COG2239	Acts as a magnesium transporter
I5Q59_RS02035	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I5Q59_RS02055	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I5Q59_RS02060	COG0515	serine threonine protein kinase
I5Q59_RS02070	COG4191	Histidine kinase
I5Q59_RS02075	COG1881	PFAM PEBP family protein
I5Q59_RS02090	COG0356	it plays a direct role in the translocation of protons across the membrane
I5Q59_RS02095	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I5Q59_RS02100	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I5Q59_RS02105	COG0012	GTP binding
I5Q59_RS02115	COG0372	Belongs to the citrate synthase family
I5Q59_RS02120	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I5Q59_RS02150	COG1408	metallophosphoesterase
I5Q59_RS02170	COG1388	LysM domain
I5Q59_RS02170	COG3942	CHAP domain
I5Q59_RS02190	COG1960	acyl-CoA dehydrogenase activity
I5Q59_RS02270	COG2258	MOSC domain
I5Q59_RS02380	COG4191	Histidine kinase
I5Q59_RS02385	COG2204	response regulator
I5Q59_RS02390	COG3852	Histidine kinase
I5Q59_RS02400	COG0006	proline dipeptidase activity
I5Q59_RS02420	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I5Q59_RS02425	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I5Q59_RS02430	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I5Q59_RS02470	COG0602	queuosine metabolic process
I5Q59_RS02475	COG2816	NAD+ diphosphatase activity
I5Q59_RS02480	COG0346	lactoylglutathione lyase activity
I5Q59_RS02495	COG2070	2-Nitropropane dioxygenase
I5Q59_RS02630	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
I5Q59_RS02660	COG4771	TonB-dependent receptor
I5Q59_RS02670	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
I5Q59_RS02670	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
I5Q59_RS02695	COG0515	serine threonine protein kinase
I5Q59_RS02695	COG2815	serine threonine protein kinase
I5Q59_RS02725	COG0436	Aminotransferase
I5Q59_RS02750	COG0551	DNA topoisomerase type I activity
I5Q59_RS02750	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I5Q59_RS02760	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I5Q59_RS02775	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I5Q59_RS02780	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I5Q59_RS02815	COG0625	glutathione transferase activity
I5Q59_RS02835	COG0515	serine threonine protein kinase
I5Q59_RS02840	COG0842	Transport permease protein
I5Q59_RS02845	COG1131	(ABC) transporter
I5Q59_RS02870	COG0488	(ABC) transporter
I5Q59_RS02875	COG1876	peptidase activity
I5Q59_RS02880	COG0501	Belongs to the peptidase M48B family
I5Q59_RS02895	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I5Q59_RS02925	COG1525	nuclease
I5Q59_RS02930	COG5002	protein histidine kinase activity
I5Q59_RS03020	COG1819	glycosyl
I5Q59_RS03035	COG1125	glycine betaine transport
I5Q59_RS03035	COG0517	IMP dehydrogenase activity
I5Q59_RS03075	COG0109	protoheme IX farnesyltransferase activity
I5Q59_RS03075	COG1612	heme a metabolic process
I5Q59_RS03080	COG2204	response regulator
I5Q59_RS03095	COG0668	transmembrane transport
I5Q59_RS03110	COG0671	phosphoesterase, PA-phosphatase related
I5Q59_RS03120	COG0110	maltose O-acetyltransferase activity
I5Q59_RS03125	COG4191	Histidine kinase
I5Q59_RS03140	COG1793	dna ligase
I5Q59_RS03145	COG3265	gluconokinase activity
I5Q59_RS03155	COG2376	Dihydroxyacetone kinase
I5Q59_RS03175	COG0488	(ABC) transporter
I5Q59_RS03200	COG1309	transcriptional regulator
I5Q59_RS03210	COG1116	anion transmembrane transporter activity
I5Q59_RS03240	COG1192	Involved in chromosome partitioning
I5Q59_RS03250	COG0501	Belongs to the peptidase M48B family
I5Q59_RS03260	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
I5Q59_RS03280	COG5002	protein histidine kinase activity
I5Q59_RS03285	COG0308	aminopeptidase N
I5Q59_RS03325	COG1846	Transcriptional regulator
I5Q59_RS03330	COG1764	response to oxidative stress
I5Q59_RS03350	COG1574	metal-dependent hydrolase with the TIM-barrel fold
I5Q59_RS03370	COG1234	tRNA 3'-trailer cleavage
I5Q59_RS03380	COG1309	transcriptional regulator
I5Q59_RS03385	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I5Q59_RS03415	COG1278	Cold shock
I5Q59_RS03445	COG0667	Aldo Keto reductase
I5Q59_RS03455	COG3795	YCII-related domain
I5Q59_RS03460	COG4941	Belongs to the sigma-70 factor family
I5Q59_RS03470	COG2124	cytochrome p450
I5Q59_RS03475	COG4604	ABC transporter, ATP-binding protein
I5Q59_RS03480	COG4605	iron ion homeostasis
I5Q59_RS03485	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5Q59_RS03490	COG4607	ABC-type enterochelin transport system periplasmic component
I5Q59_RS03525	COG0577	efflux transmembrane transporter activity
I5Q59_RS03525	COG1136	(ABC) transporter
I5Q59_RS03565	COG2031	fatty acid transporter
I5Q59_RS03575	COG5002	protein histidine kinase activity
I5Q59_RS03590	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
I5Q59_RS03595	COG0745	RESPONSE REGULATOR receiver
I5Q59_RS03605	COG2205	protein histidine kinase activity
I5Q59_RS03605	COG4999	Histidine kinase
I5Q59_RS03605	COG3437	response regulator, receiver
I5Q59_RS03605	COG3850	Histidine kinase
I5Q59_RS03610	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I5Q59_RS03615	COG2201	protein-glutamate methylesterase activity
I5Q59_RS03620	COG3437	response regulator, receiver
I5Q59_RS03645	COG1131	(ABC) transporter
I5Q59_RS03665	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I5Q59_RS03670	COG0745	RESPONSE REGULATOR receiver
I5Q59_RS03690	COG3483	tryptophan 2,3-dioxygenase activity
I5Q59_RS03695	COG0745	RESPONSE REGULATOR receiver
I5Q59_RS03700	COG2205	protein histidine kinase activity
I5Q59_RS03700	COG3437	response regulator, receiver
I5Q59_RS03700	COG3850	Histidine kinase
I5Q59_RS03700	COG4999	Histidine kinase
I5Q59_RS03720	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I5Q59_RS03770	COG1132	(ABC) transporter
I5Q59_RS03780	COG0484	heat shock protein binding
I5Q59_RS03825	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I5Q59_RS03840	COG0745	RESPONSE REGULATOR receiver
I5Q59_RS03865	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I5Q59_RS03885	COG3842	ATPase activity
I5Q59_RS03895	COG0300	oxidoreductase activity
I5Q59_RS03920	COG0330	HflC and HflK could
I5Q59_RS03930	COG0438	transferase activity, transferring glycosyl groups
I5Q59_RS03945	COG0583	DNA-binding transcription factor activity
I5Q59_RS03960	COG0537	adenosine 5'-monophosphoramidase activity
I5Q59_RS03975	COG0612	Peptidase, M16
I5Q59_RS04005	COG1960	acyl-CoA dehydrogenase activity
I5Q59_RS04050	COG0679	Auxin Efflux Carrier
I5Q59_RS04105	COG0300	oxidoreductase activity
I5Q59_RS04190	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I5Q59_RS04225	COG0604	alcohol dehydrogenase
I5Q59_RS04245	COG3383	formate dehydrogenase (NAD+) activity
I5Q59_RS04255	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I5Q59_RS04265	COG1360	Flagellar Motor Protein
I5Q59_RS04280	COG0443	Heat shock 70 kDa protein
I5Q59_RS04305	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
I5Q59_RS04310	COG0625	glutathione transferase activity
I5Q59_RS04320	COG0783	Belongs to the Dps family
I5Q59_RS04380	COG0840	transmembrane signaling receptor activity
I5Q59_RS04410	COG2819	hydrolase of the alpha beta superfamily
I5Q59_RS04425	COG1309	transcriptional regulator
I5Q59_RS04430	COG1408	metallophosphoesterase
I5Q59_RS04455	COG1090	epimerase
I5Q59_RS04465	COG0142	geranyltranstransferase activity
I5Q59_RS04475	COG1562	ergosterol biosynthetic process
I5Q59_RS04480	COG1233	COG1233 Phytoene dehydrogenase and related
I5Q59_RS04525	COG0515	serine threonine protein kinase
I5Q59_RS04530	COG2204	response regulator
I5Q59_RS04555	COG0174	glutamine synthetase
I5Q59_RS04575	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I5Q59_RS04580	COG3844	kynureninase activity
I5Q59_RS04590	COG0662	Cupin 2, conserved barrel domain protein
I5Q59_RS04635	COG4191	Histidine kinase
I5Q59_RS04655	COG1297	OPT oligopeptide transporter protein
I5Q59_RS04660	COG0515	serine threonine protein kinase
I5Q59_RS04660	COG2815	serine threonine protein kinase
I5Q59_RS04665	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I5Q59_RS04680	COG2204	response regulator
I5Q59_RS04710	COG1846	Transcriptional regulator
I5Q59_RS04745	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I5Q59_RS04755	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I5Q59_RS04760	COG0363	glucosamine-6-phosphate deaminase activity
I5Q59_RS04765	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I5Q59_RS04790	COG0420	3'-5' exonuclease activity
I5Q59_RS04825	COG1464	Belongs to the NlpA lipoprotein family
I5Q59_RS04830	COG2011	ABC-type metal ion transport system permease component
I5Q59_RS04835	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I5Q59_RS04840	COG0626	cystathionine gamma-synthase activity
I5Q59_RS04845	COG0626	cystathionine gamma-synthase activity
I5Q59_RS04850	COG0527	aspartate kinase activity
I5Q59_RS04850	COG0460	homoserine dehydrogenase
I5Q59_RS04870	COG1858	cytochrome C peroxidase
I5Q59_RS04905	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I5Q59_RS04920	COG3023	N-Acetylmuramoyl-L-alanine amidase
I5Q59_RS04960	COG3842	ATPase activity
I5Q59_RS04965	COG0644	oxidoreductase
I5Q59_RS04970	COG1201	RNA secondary structure unwinding
I5Q59_RS04975	COG1404	Belongs to the peptidase S8 family
I5Q59_RS05030	COG0402	S-adenosylhomocysteine deaminase activity
I5Q59_RS05050	COG5002	protein histidine kinase activity
I5Q59_RS05065	COG4968	Prepilin-type N-terminal cleavage methylation domain
I5Q59_RS05095	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I5Q59_RS05105	COG0438	transferase activity, transferring glycosyl groups
I5Q59_RS05110	COG0438	transferase activity, transferring glycosyl groups
I5Q59_RS05125	COG0438	transferase activity, transferring glycosyl groups
I5Q59_RS05135	COG0438	transferase activity, transferring glycosyl groups
I5Q59_RS05160	COG1216	Glycosyl transferase, family 2
I5Q59_RS05160	COG0463	Glycosyl transferase, family 2
I5Q59_RS05170	COG1940	carbohydrate kinase activity
I5Q59_RS05185	COG0438	transferase activity, transferring glycosyl groups
I5Q59_RS05190	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I5Q59_RS05250	COG3724	N-succinylarginine dihydrolase activity
I5Q59_RS05255	COG1560	Kdo2-lipid A biosynthetic process
I5Q59_RS05270	COG1137	ATPase activity
I5Q59_RS05295	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I5Q59_RS05300	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5Q59_RS05310	COG1490	D-aminoacyl-tRNA deacylase activity
I5Q59_RS05315	COG2027	D-alanyl-D-alanine carboxypeptidase
I5Q59_RS05320	COG0629	single-stranded DNA binding
I5Q59_RS05325	COG2009	succinate dehydrogenase
I5Q59_RS05330	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I5Q59_RS05340	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I5Q59_RS05350	COG4191	Histidine kinase
I5Q59_RS05360	COG0456	acetyltransferase
I5Q59_RS05365	COG1007	ATP synthesis coupled electron transport
I5Q59_RS05380	COG0713	ATP synthesis coupled electron transport
I5Q59_RS05385	COG0839	Belongs to the complex I subunit 6 family
I5Q59_RS05410	COG3830	Belongs to the UPF0237 family
I5Q59_RS05410	COG0560	Phosphoserine phosphatase
I5Q59_RS05425	COG0071	Belongs to the small heat shock protein (HSP20) family
I5Q59_RS05430	COG0745	RESPONSE REGULATOR receiver
I5Q59_RS05435	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I5Q59_RS05440	COG2877	3-deoxy-8-phosphooctulonate synthase activity
I5Q59_RS05445	COG0504	CTP synthase activity
I5Q59_RS05455	COG1132	(ABC) transporter
I5Q59_RS05460	COG0656	L-ascorbic acid biosynthetic process
I5Q59_RS05470	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
I5Q59_RS05480	COG0564	pseudouridine synthase activity
I5Q59_RS05485	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I5Q59_RS05500	COG0484	heat shock protein binding
I5Q59_RS05520	COG5016	pyruvate
I5Q59_RS05520	COG0511	ligase activity, forming carbon-carbon bonds
I5Q59_RS05525	COG0439	Biotin carboxylase
I5Q59_RS05535	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I5Q59_RS05580	COG2264	protein methyltransferase activity
I5Q59_RS05590	COG2264	protein methyltransferase activity
I5Q59_RS05605	COG2204	response regulator
I5Q59_RS05610	COG4191	Histidine kinase
I5Q59_RS05620	COG1714	RDD family
I5Q59_RS05635	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I5Q59_RS05665	COG2264	protein methyltransferase activity
I5Q59_RS05675	COG0612	Peptidase, M16
I5Q59_RS05730	COG1959	2 iron, 2 sulfur cluster binding
I5Q59_RS05735	COG0719	Fe-S assembly protein
I5Q59_RS05740	COG0396	ATPase activity
I5Q59_RS05745	COG0719	Fe-S assembly protein
I5Q59_RS05755	COG0822	iron-sulfur transferase activity
I5Q59_RS05770	COG1446	asparaginase
I5Q59_RS05785	COG0515	serine threonine protein kinase
I5Q59_RS05785	COG2815	serine threonine protein kinase
I5Q59_RS05805	COG2205	protein histidine kinase activity
I5Q59_RS05810	COG2204	response regulator
I5Q59_RS05830	COG1376	ErfK ybiS ycfS ynhG family protein
I5Q59_RS05835	COG0432	Pfam Uncharacterised protein family UPF0047
I5Q59_RS05855	COG0544	peptidyl-prolyl cis-trans isomerase activity
I5Q59_RS05865	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
I5Q59_RS05885	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
I5Q59_RS05920	COG5000	phosphorelay sensor kinase activity
I5Q59_RS05965	COG1040	competence protein
I5Q59_RS06160	COG0515	serine threonine protein kinase
I5Q59_RS06170	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
I5Q59_RS06180	COG1690	Belongs to the RtcB family
I5Q59_RS06185	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
I5Q59_RS06235	COG3852	Histidine kinase
I5Q59_RS06240	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I5Q59_RS06260	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I5Q59_RS06270	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I5Q59_RS06275	COG0156	8-amino-7-oxononanoate synthase activity
I5Q59_RS06280	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I5Q59_RS06305	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
I5Q59_RS06310	COG3273	potassium ion transport
I5Q59_RS06310	COG0471	metal ion transport
I5Q59_RS06340	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I5Q59_RS06360	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I5Q59_RS06380	COG3279	Response regulator of the LytR AlgR family
I5Q59_RS06385	COG3275	phosphorelay sensor kinase activity
I5Q59_RS06390	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I5Q59_RS06395	COG0473	3-isopropylmalate dehydrogenase activity
I5Q59_RS06415	COG1132	(ABC) transporter
I5Q59_RS06435	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I5Q59_RS06465	COG0297	glycogen (starch) synthase activity
I5Q59_RS06490	COG4535	Mg2 and Co2 transporter CorC
I5Q59_RS06550	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
I5Q59_RS06570	COG4771	TonB-dependent receptor
I5Q59_RS06580	COG3720	iron ion transport
I5Q59_RS06590	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5Q59_RS06595	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
I5Q59_RS06600	COG2826	transposase and inactivated derivatives, IS30 family
I5Q59_RS06715	COG3604	Transcriptional regulator
I5Q59_RS06735	COG0745	RESPONSE REGULATOR receiver
I5Q59_RS06740	COG5002	protein histidine kinase activity
I5Q59_RS06760	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I5Q59_RS06775	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I5Q59_RS06800	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I5Q59_RS06805	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I5Q59_RS06810	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I5Q59_RS06845	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I5Q59_RS06855	COG0123	including yeast histone deacetylase and acetoin utilization protein
I5Q59_RS06910	COG0405	Gamma-glutamyltransferase
I5Q59_RS06920	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I5Q59_RS06925	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I5Q59_RS06950	COG2183	response to ionizing radiation
I5Q59_RS06965	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I5Q59_RS06980	COG1413	lyase activity
I5Q59_RS06990	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I5Q59_RS06995	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I5Q59_RS07020	COG1028	Short-chain dehydrogenase reductase Sdr
I5Q59_RS07060	COG0840	transmembrane signaling receptor activity
I5Q59_RS07070	COG1028	Short-chain dehydrogenase reductase Sdr
I5Q59_RS07095	COG0564	pseudouridine synthase activity
I5Q59_RS07100	COG1215	transferase activity, transferring glycosyl groups
I5Q59_RS07115	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I5Q59_RS07130	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I5Q59_RS07135	COG0484	heat shock protein binding
I5Q59_RS07140	COG0242	peptide deformylase activity
I5Q59_RS07145	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I5Q59_RS07155	COG0739	heme binding
I5Q59_RS07160	COG0776	regulation of translation
I5Q59_RS07175	COG1183	phosphatidylcholine synthase activity
I5Q59_RS07180	COG1058	Belongs to the CinA family
I5Q59_RS07180	COG1546	Belongs to the CinA family
I5Q59_RS07200	COG1252	NADH dehydrogenase
I5Q59_RS07205	COG0606	chelatase, subunit chli
I5Q59_RS07275	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
I5Q59_RS07280	COG0116	Belongs to the methyltransferase superfamily
I5Q59_RS07280	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I5Q59_RS07300	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I5Q59_RS07305	COG0154	amidase activity
I5Q59_RS07310	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I5Q59_RS07335	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I5Q59_RS07340	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I5Q59_RS07345	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I5Q59_RS07370	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I5Q59_RS07380	COG1666	GTP binding
I5Q59_RS07385	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I5Q59_RS07470	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I5Q59_RS07505	COG1515	deoxyribonuclease V activity
I5Q59_RS07535	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I5Q59_RS07570	COG0210	DNA helicase
I5Q59_RS07580	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I5Q59_RS07585	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I5Q59_RS07595	COG1690	Belongs to the RtcB family
I5Q59_RS07610	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I5Q59_RS07625	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I5Q59_RS07630	COG0318	PFAM AMP-dependent synthetase and ligase
I5Q59_RS07670	COG2967	ApaG domain
I5Q59_RS07690	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I5Q59_RS07715	COG0009	L-threonylcarbamoyladenylate synthase
I5Q59_RS07720	COG1090	epimerase
I5Q59_RS07755	COG2202	Pas domain
I5Q59_RS07755	COG2205	protein histidine kinase activity
I5Q59_RS07765	COG0723	plastoquinol--plastocyanin reductase activity
I5Q59_RS07765	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I5Q59_RS07780	COG2814	Major facilitator Superfamily
I5Q59_RS07785	COG0531	amino acid
I5Q59_RS07790	COG2264	protein methyltransferase activity
I5Q59_RS07810	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I5Q59_RS07815	COG0450	alkyl hydroperoxide reductase
I5Q59_RS07820	COG3604	Transcriptional regulator
I5Q59_RS07835	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
I5Q59_RS07845	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I5Q59_RS07855	COG1045	serine acetyltransferase
I5Q59_RS07860	COG0318	PFAM AMP-dependent synthetase and ligase
I5Q59_RS07865	COG3070	regulator of competence-specific genes
I5Q59_RS07870	COG0583	DNA-binding transcription factor activity
I5Q59_RS07875	COG0477	Major facilitator Superfamily
I5Q59_RS07880	COG0515	serine threonine protein kinase
I5Q59_RS07880	COG2815	serine threonine protein kinase
I5Q59_RS07890	COG1238	metal cluster binding
I5Q59_RS07900	COG0628	permease
I5Q59_RS07925	COG1187	pseudouridine synthase activity
I5Q59_RS07940	COG0512	Glutamine amidotransferase of anthranilate synthase
I5Q59_RS07945	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I5Q59_RS07990	COG2264	protein methyltransferase activity
I5Q59_RS07995	COG0436	Aminotransferase
I5Q59_RS08010	COG1028	Short-chain dehydrogenase reductase Sdr
I5Q59_RS08010	COG0300	oxidoreductase activity
I5Q59_RS08010	COG0318	PFAM AMP-dependent synthetase and ligase
I5Q59_RS08010	COG3321	synthase
I5Q59_RS08010	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I5Q59_RS08050	COG2010	Cytochrome c
I5Q59_RS08080	COG1278	Cold shock
I5Q59_RS08090	COG2378	regulation of single-species biofilm formation
I5Q59_RS08165	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I5Q59_RS08175	COG0531	amino acid
I5Q59_RS08185	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I5Q59_RS08205	COG1959	2 iron, 2 sulfur cluster binding
I5Q59_RS08210	COG2267	carboxylic ester hydrolase activity
I5Q59_RS08220	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
I5Q59_RS08300	COG2814	Major facilitator Superfamily
I5Q59_RS08350	COG2937	Belongs to the GPAT DAPAT family
I5Q59_RS08355	COG0277	FAD linked oxidase domain protein
I5Q59_RS08360	COG1309	transcriptional regulator
I5Q59_RS08370	COG0642	Histidine kinase
I5Q59_RS08385	COG0823	Involved in the tonB-independent uptake of proteins
I5Q59_RS08385	COG1506	peptidase
I5Q59_RS08390	COG0583	DNA-binding transcription factor activity
I5Q59_RS08405	COG0456	acetyltransferase
I5Q59_RS08415	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
I5Q59_RS08450	COG1136	(ABC) transporter
I5Q59_RS08450	COG0577	efflux transmembrane transporter activity
I5Q59_RS08470	COG0596	Alpha beta hydrolase
I5Q59_RS08525	COG0515	serine threonine protein kinase
I5Q59_RS08530	COG0583	DNA-binding transcription factor activity
I5Q59_RS08595	COG0583	DNA-binding transcription factor activity
I5Q59_RS08610	COG3811	Belongs to the UPF0386 family
I5Q59_RS08680	COG0753	catalase activity
I5Q59_RS08690	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I5Q59_RS08740	COG0667	Aldo Keto reductase
I5Q59_RS08745	COG0583	DNA-binding transcription factor activity
I5Q59_RS08760	COG1846	Transcriptional regulator
I5Q59_RS08790	COG2963	transposase activity
I5Q59_RS08900	COG1132	(ABC) transporter
I5Q59_RS08905	COG1132	(ABC) transporter
I5Q59_RS08920	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I5Q59_RS08955	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I5Q59_RS08990	COG1714	RDD family
I5Q59_RS09255	COG4653	Phage capsid family
I5Q59_RS09265	COG0338	D12 class N6 adenine-specific DNA methyltransferase
I5Q59_RS09285	COG5518	Phage portal protein
I5Q59_RS09320	COG4974	Belongs to the 'phage' integrase family
I5Q59_RS09340	COG2176	DNA-directed DNA polymerase activity
I5Q59_RS09415	COG0515	serine threonine protein kinase
I5Q59_RS09415	COG2815	serine threonine protein kinase
I5Q59_RS09435	COG0515	serine threonine protein kinase
I5Q59_RS09495	COG1222	aaa ATPase
I5Q59_RS09505	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I5Q59_RS09505	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I5Q59_RS09510	COG1619	proteins homologs of microcin C7 resistance protein MccF
I5Q59_RS09515	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I5Q59_RS09520	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I5Q59_RS09525	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I5Q59_RS09530	COG0483	inositol monophosphate 1-phosphatase activity
I5Q59_RS09550	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I5Q59_RS09585	COG1100	Small GTP-binding protein
I5Q59_RS09605	COG0515	serine threonine protein kinase
I5Q59_RS09610	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I5Q59_RS09615	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
I5Q59_RS09625	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I5Q59_RS09650	COG0590	tRNA wobble adenosine to inosine editing
I5Q59_RS09670	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I5Q59_RS09700	COG1088	dTDP-glucose 4,6-dehydratase activity
I5Q59_RS09715	COG0514	ATP-dependent DNA helicase (RecQ)
I5Q59_RS09725	COG2003	Belongs to the UPF0758 family
I5Q59_RS09730	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I5Q59_RS09735	COG0492	ferredoxin-NADP+ reductase activity
I5Q59_RS09785	COG1832	CoA-binding protein
I5Q59_RS09805	COG2226	methyltransferase
I5Q59_RS09810	COG0646	methionine synthase
I5Q59_RS09810	COG1410	methionine synthase
I5Q59_RS09840	COG1028	Short-chain dehydrogenase reductase Sdr
I5Q59_RS09850	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I5Q59_RS09885	COG0424	maF-like protein
I5Q59_RS09910	COG0210	DNA helicase
I5Q59_RS09915	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I5Q59_RS09935	COG2137	regulation of response to DNA damage stimulus
I5Q59_RS09960	COG0709	Synthesizes selenophosphate from selenide and ATP
I5Q59_RS09965	COG4991	sh3 domain protein
I5Q59_RS09965	COG3103	Sh3 type 3 domain protein
I5Q59_RS09965	COG0860	N-Acetylmuramoyl-L-alanine amidase
I5Q59_RS09970	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
I5Q59_RS09975	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I5Q59_RS10015	COG0544	peptidyl-prolyl cis-trans isomerase activity
I5Q59_RS10020	COG0740	serine-type endopeptidase activity
I5Q59_RS10030	COG1505	serine-type exopeptidase activity
I5Q59_RS10040	COG4166	transmembrane transport
I5Q59_RS10060	COG1678	Uncharacterized ACR, COG1678
I5Q59_RS10065	COG0271	Belongs to the BolA IbaG family
I5Q59_RS10070	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I5Q59_RS10080	COG0006	proline dipeptidase activity
I5Q59_RS10090	COG3148	PFAM DTW domain containing protein
I5Q59_RS10100	COG1595	DNA-templated transcription, initiation
I5Q59_RS10115	COG1573	uracil-dna glycosylase
I5Q59_RS10125	COG0626	cystathionine gamma-synthase activity
I5Q59_RS10145	COG2030	dehydratase
I5Q59_RS10160	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I5Q59_RS10165	COG0631	protein serine/threonine phosphatase activity
I5Q59_RS10210	COG0484	heat shock protein binding
I5Q59_RS10220	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I5Q59_RS10225	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I5Q59_RS10235	COG1428	Deoxynucleoside kinase
I5Q59_RS10240	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
I5Q59_RS10245	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I5Q59_RS10250	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I5Q59_RS10290	COG0779	Required for maturation of 30S ribosomal subunits
I5Q59_RS10305	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I5Q59_RS10315	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I5Q59_RS10320	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I5Q59_RS10325	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I5Q59_RS10330	COG1185	polyribonucleotide nucleotidyltransferase activity
I5Q59_RS10340	COG0739	heme binding
I5Q59_RS10345	COG0756	dUTP diphosphatase activity
I5Q59_RS10360	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I5Q59_RS10385	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I5Q59_RS10400	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I5Q59_RS10420	COG0612	Peptidase, M16
I5Q59_RS10470	COG3344	reverse transcriptase
I5Q59_RS10480	COG2801	Transposase and inactivated derivatives
I5Q59_RS10490	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I5Q59_RS10540	COG3850	Histidine kinase
I5Q59_RS10540	COG3437	response regulator, receiver
I5Q59_RS10540	COG2205	protein histidine kinase activity
I5Q59_RS10540	COG4999	Histidine kinase
I5Q59_RS10595	COG0583	DNA-binding transcription factor activity
I5Q59_RS10620	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I5Q59_RS10630	COG0667	Aldo Keto reductase
I5Q59_RS10645	COG2356	endonuclease I
I5Q59_RS10680	COG1643	Atp-dependent helicase
I5Q59_RS10695	COG2130	NADP-dependent
I5Q59_RS10770	COG4584	PFAM Integrase catalytic
I5Q59_RS10775	COG1484	DNA-dependent DNA replication
I5Q59_RS10815	COG0515	serine threonine protein kinase
I5Q59_RS10820	COG0515	serine threonine protein kinase
I5Q59_RS10830	COG1250	3-hydroxyacyl-CoA dehydrogenase
I5Q59_RS10855	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I5Q59_RS10870	COG2133	pyrroloquinoline quinone binding
I5Q59_RS10915	COG0657	acetylesterase activity
I5Q59_RS10955	COG1268	BioY protein
I5Q59_RS10980	COG2814	Major facilitator Superfamily
I5Q59_RS11015	COG0194	GDP metabolic process
I5Q59_RS11050	COG2755	lipolytic protein G-D-S-L family
I5Q59_RS11050	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
I5Q59_RS11055	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I5Q59_RS11095	COG3226	Transcriptional regulator
I5Q59_RS11105	COG0737	Belongs to the 5'-nucleotidase family
I5Q59_RS11110	COG1335	isochorismatase
I5Q59_RS11140	COG2226	methyltransferase
I5Q59_RS11150	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I5Q59_RS11155	COG0277	FAD linked oxidase domain protein
I5Q59_RS11175	COG4176	ABC-type proline glycine betaine transport system permease component
I5Q59_RS11180	COG2113	Glycine betaine
I5Q59_RS11185	COG3869	Catalyzes the specific phosphorylation of arginine residues in
I5Q59_RS11205	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I5Q59_RS11215	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I5Q59_RS11225	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I5Q59_RS11225	COG4651	solute:proton antiporter activity
I5Q59_RS11230	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I5Q59_RS11230	COG1703	isobutyryl-CoA mutase activity
I5Q59_RS11230	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I5Q59_RS11235	COG1703	isobutyryl-CoA mutase activity
I5Q59_RS11250	COG0328	RNA-DNA hybrid ribonuclease activity
I5Q59_RS11255	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I5Q59_RS11260	COG2070	2-Nitropropane dioxygenase
I5Q59_RS11265	COG1136	(ABC) transporter
I5Q59_RS11265	COG0577	efflux transmembrane transporter activity
I5Q59_RS11320	COG0306	phosphate transporter
I5Q59_RS11330	COG1064	alcohol dehydrogenase
I5Q59_RS11335	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I5Q59_RS11345	COG0427	acetyl-CoA hydrolase
I5Q59_RS11350	COG0339	signal peptide processing
I5Q59_RS11355	COG0351	phosphomethylpyrimidine kinase
I5Q59_RS11365	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I5Q59_RS11395	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
I5Q59_RS11410	COG0017	Asparaginyl-tRNA synthetase
I5Q59_RS11440	COG2124	cytochrome p450
I5Q59_RS11450	COG0813	purine-nucleoside phosphorylase activity
I5Q59_RS11465	COG0513	Belongs to the DEAD box helicase family
I5Q59_RS11490	COG1063	alcohol dehydrogenase
I5Q59_RS11505	COG2205	protein histidine kinase activity
I5Q59_RS11505	COG3437	response regulator, receiver
I5Q59_RS11505	COG3850	Histidine kinase
I5Q59_RS11505	COG4999	Histidine kinase
I5Q59_RS11520	COG3541	Predicted nucleotidyltransferase
I5Q59_RS11540	COG3228	Belongs to the MtfA family
I5Q59_RS11545	COG1072	(Pantothenic acid kinase))
I5Q59_RS11560	COG2153	protein acetylation
I5Q59_RS11570	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I5Q59_RS11585	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I5Q59_RS11590	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I5Q59_RS11600	COG0175	sulfate reduction
I5Q59_RS11605	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I5Q59_RS11605	COG1648	precorrin-2 dehydrogenase activity
I5Q59_RS11610	COG1648	precorrin-2 dehydrogenase activity
I5Q59_RS11610	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I5Q59_RS11615	COG0175	sulfate reduction
I5Q59_RS11650	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I5Q59_RS11650	COG0047	phosphoribosylformylglycinamidine synthase activity
I5Q59_RS11655	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I5Q59_RS11660	COG0517	IMP dehydrogenase activity
I5Q59_RS11665	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I5Q59_RS11695	COG0019	diaminopimelate decarboxylase activity
I5Q59_RS11700	COG1215	transferase activity, transferring glycosyl groups
I5Q59_RS11710	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
I5Q59_RS11720	COG0438	transferase activity, transferring glycosyl groups
I5Q59_RS11725	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I5Q59_RS11750	COG5002	protein histidine kinase activity
I5Q59_RS11755	COG1218	3'(2'),5'-bisphosphate nucleotidase
I5Q59_RS11765	COG3663	DNA glycosylase
I5Q59_RS11780	COG4297	protein containing double-stranded beta helix domain
I5Q59_RS11785	COG1228	amidohydrolase
I5Q59_RS11795	COG2363	Small membrane protein
I5Q59_RS11825	COG2943	transferase activity, transferring hexosyl groups
I5Q59_RS11835	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
I5Q59_RS11850	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I5Q59_RS11855	COG0386	Belongs to the glutathione peroxidase family
I5Q59_RS11900	COG3064	Membrane
I5Q59_RS11900	COG4991	sh3 domain protein
I5Q59_RS11900	COG0515	serine threonine protein kinase
I5Q59_RS11920	COG1301	dicarboxylic acid transport
I5Q59_RS11925	COG1047	Peptidyl-prolyl cis-trans
I5Q59_RS11940	COG0488	(ABC) transporter
I5Q59_RS11945	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I5Q59_RS11975	COG1187	pseudouridine synthase activity
I5Q59_RS11990	COG2373	Large extracellular alpha-helical protein
I5Q59_RS11995	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I5Q59_RS12000	COG4953	penicillin-binding protein 1C
I5Q59_RS12025	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I5Q59_RS12045	COG1136	(ABC) transporter
I5Q59_RS12045	COG0577	efflux transmembrane transporter activity
I5Q59_RS12055	COG1136	(ABC) transporter
I5Q59_RS12090	COG1191	sigma factor activity
I5Q59_RS12145	COG1987	bacterial-type flagellum assembly
I5Q59_RS12155	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I5Q59_RS12160	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I5Q59_RS12215	COG4789	Type iii secretion
I5Q59_RS12220	COG1716	ATPase activity
I5Q59_RS12265	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I5Q59_RS12275	COG0714	Associated with various cellular activities
I5Q59_RS12300	COG0616	signal peptide processing
I5Q59_RS12315	COG0187	DNA topoisomerase II activity
I5Q59_RS12320	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I5Q59_RS12340	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I5Q59_RS12345	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I5Q59_RS12450	COG1459	type II secretion system
I5Q59_RS12480	COG0312	modulator of DNA gyrase
I5Q59_RS12485	COG0312	modulator of DNA gyrase
I5Q59_RS12495	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I5Q59_RS12510	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I5Q59_RS12545	COG3300	MHYT domain
I5Q59_RS12545	COG5001	Diguanylate cyclase
I5Q59_RS12560	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I5Q59_RS12565	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I5Q59_RS12570	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I5Q59_RS12575	COG1022	Amp-dependent synthetase and ligase
I5Q59_RS12610	COG0416	fatty acid biosynthetic process
I5Q59_RS12625	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I5Q59_RS12635	COG0564	pseudouridine synthase activity
I5Q59_RS12670	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I5Q59_RS12675	COG4589	Belongs to the CDS family
I5Q59_RS12680	COG0750	zinc metalloprotease
I5Q59_RS12685	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I5Q59_RS12690	COG1214	PFAM Peptidase M22, glycoprotease
I5Q59_RS12715	COG0314	molybdopterin synthase activity
I5Q59_RS12745	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I5Q59_RS12750	COG0156	8-amino-7-oxononanoate synthase activity
I5Q59_RS12755	COG0406	alpha-ribazole phosphatase activity
I5Q59_RS12765	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I5Q59_RS12785	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I5Q59_RS12785	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I5Q59_RS12825	COG0515	serine threonine protein kinase
I5Q59_RS12835	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I5Q59_RS12840	COG0316	Belongs to the HesB IscA family
I5Q59_RS12855	COG0584	glycerophosphoryl diester phosphodiesterase
I5Q59_RS12905	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I5Q59_RS12925	COG3104	oligopeptide transport
I5Q59_RS12945	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I5Q59_RS12965	COG0456	acetyltransferase
I5Q59_RS12975	COG1074	ATP-dependent DNA helicase activity
I5Q59_RS12980	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I5Q59_RS13020	COG2333	competence protein COMEC
I5Q59_RS13020	COG0658	competence protein
I5Q59_RS13025	COG1329	Transcriptional regulator
I5Q59_RS13040	COG0215	cysteine-tRNA ligase activity
I5Q59_RS13050	COG0556	nucleotide-excision repair
I5Q59_RS13055	COG0322	excinuclease ABC activity
I5Q59_RS13105	COG0424	maF-like protein
I5Q59_RS13110	COG3706	GGDEF domain
I5Q59_RS13115	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I5Q59_RS13135	COG0772	Belongs to the SEDS family
I5Q59_RS13155	COG3118	belongs to the thioredoxin family
I5Q59_RS13170	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
I5Q59_RS13175	COG0181	hydroxymethylbilane synthase activity
I5Q59_RS13180	COG1587	Uroporphyrinogen-III synthase
I5Q59_RS13185	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I5Q59_RS13225	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I5Q59_RS13230	COG0022	dehydrogenase e1 component
I5Q59_RS13235	COG0508	dehydrogenase complex catalyzes the overall conversion of
I5Q59_RS13280	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I5Q59_RS13325	COG0784	Response regulator, receiver
I5Q59_RS13375	COG1100	Small GTP-binding protein
I5Q59_RS13380	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I5Q59_RS13390	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I5Q59_RS13395	COG1024	Enoyl-CoA hydratase
I5Q59_RS13400	COG1683	Conserved Protein
I5Q59_RS13405	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I5Q59_RS13410	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I5Q59_RS13415	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I5Q59_RS13425	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I5Q59_RS13430	COG0285	dihydrofolate synthase activity
I5Q59_RS13450	COG1396	sequence-specific DNA binding
I5Q59_RS13460	COG1309	transcriptional regulator
I5Q59_RS13465	COG1024	Enoyl-CoA hydratase
I5Q59_RS13520	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
I5Q59_RS13530	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I5Q59_RS13535	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
I5Q59_RS13540	COG1034	ATP synthesis coupled electron transport
I5Q59_RS13545	COG0649	NAD binding
I5Q59_RS13550	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I5Q59_RS13565	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I5Q59_RS13570	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I5Q59_RS13595	COG0613	PHP domain protein
I5Q59_RS13615	COG1166	arginine decarboxylase activity
I5Q59_RS13630	COG0484	heat shock protein binding
I5Q59_RS13635	COG0443	Heat shock 70 kDa protein
I5Q59_RS13695	COG0521	Mo-molybdopterin cofactor biosynthetic process
I5Q59_RS13715	COG4191	Histidine kinase
I5Q59_RS13790	COG0745	RESPONSE REGULATOR receiver
I5Q59_RS13810	COG1136	(ABC) transporter
I5Q59_RS13810	COG0577	efflux transmembrane transporter activity
I5Q59_RS13820	COG2205	protein histidine kinase activity
I5Q59_RS13820	COG0784	Response regulator, receiver
I5Q59_RS13830	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
I5Q59_RS13840	COG0534	Mate efflux family protein
I5Q59_RS13870	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I5Q59_RS13890	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I5Q59_RS13915	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I5Q59_RS13915	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I5Q59_RS13925	COG0084	hydrolase, TatD family'
I5Q59_RS13935	COG3481	metal-dependent phosphohydrolase, HD sub domain
I5Q59_RS13940	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I5Q59_RS13950	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
I5Q59_RS13960	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I5Q59_RS13970	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I5Q59_RS13975	COG0126	phosphoglycerate kinase activity
I5Q59_RS13980	COG0149	triose-phosphate isomerase activity
I5Q59_RS14040	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I5Q59_RS14045	COG1116	anion transmembrane transporter activity
I5Q59_RS14085	COG1012	belongs to the aldehyde dehydrogenase family
I5Q59_RS14090	COG0583	DNA-binding transcription factor activity
I5Q59_RS14100	COG1012	belongs to the aldehyde dehydrogenase family
I5Q59_RS14105	COG1739	Uncharacterized protein family UPF0029
I5Q59_RS14110	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I5Q59_RS14175	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I5Q59_RS14225	COG1309	transcriptional regulator
I5Q59_RS14240	COG2072	flavoprotein involved in K transport
I5Q59_RS14255	COG0628	permease
I5Q59_RS14275	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I5Q59_RS14320	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I5Q59_RS14370	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I5Q59_RS14410	COG2366	antibiotic biosynthetic process
I5Q59_RS14415	COG1183	phosphatidylcholine synthase activity
I5Q59_RS14430	COG0515	serine threonine protein kinase
I5Q59_RS14445	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I5Q59_RS14450	COG0138	bifunctional purine biosynthesis protein purh
I5Q59_RS14460	COG0151	Belongs to the GarS family
I5Q59_RS14480	COG0438	transferase activity, transferring glycosyl groups
I5Q59_RS14490	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I5Q59_RS14515	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I5Q59_RS14610	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I5Q59_RS14615	COG1120	ATPase activity
I5Q59_RS14645	COG0302	gtp cyclohydrolase
I5Q59_RS14650	COG0277	FAD linked oxidase domain protein
I5Q59_RS14670	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I5Q59_RS14680	COG0745	RESPONSE REGULATOR receiver
I5Q59_RS14690	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I5Q59_RS14700	COG1846	Transcriptional regulator
I5Q59_RS14715	COG1960	acyl-CoA dehydrogenase activity
I5Q59_RS14720	COG1301	dicarboxylic acid transport
I5Q59_RS14735	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
I5Q59_RS14750	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I5Q59_RS14755	COG1692	metallophosphoesterase
I5Q59_RS14775	COG0515	serine threonine protein kinase
I5Q59_RS14825	COG0745	RESPONSE REGULATOR receiver
I5Q59_RS14825	COG1196	nuclear chromosome segregation
I5Q59_RS14840	COG1543	Belongs to the glycosyl hydrolase 57 family
I5Q59_RS14845	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I5Q59_RS14860	COG1496	oxidoreductase activity
I5Q59_RS14875	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I5Q59_RS14900	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
I5Q59_RS14920	COG0471	metal ion transport
I5Q59_RS14920	COG0490	domain, Protein
I5Q59_RS14925	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
I5Q59_RS14930	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
I5Q59_RS14940	COG0484	heat shock protein binding
I5Q59_RS14945	COG0443	Heat shock 70 kDa protein
I5Q59_RS14970	COG0237	dephospho-CoA kinase activity
I5Q59_RS14985	COG0218	Necessary for normal cell division and for the maintenance of normal septation
I5Q59_RS15010	COG0167	dihydroorotate dehydrogenase activity
I5Q59_RS15025	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
I5Q59_RS15030	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I5Q59_RS15050	COG3852	Histidine kinase
I5Q59_RS15065	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I5Q59_RS15075	COG0509	glycine decarboxylation via glycine cleavage system
I5Q59_RS15080	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I5Q59_RS15080	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I5Q59_RS15085	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I5Q59_RS15110	COG1960	acyl-CoA dehydrogenase activity
I5Q59_RS15120	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I5Q59_RS15145	COG1643	Atp-dependent helicase
I5Q59_RS15175	COG0189	ligase activity
I5Q59_RS15185	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I5Q59_RS15210	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I5Q59_RS15215	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I5Q59_RS15235	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I5Q59_RS15240	COG0081	regulation of translation
I5Q59_RS15245	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I5Q59_RS15250	COG0222	ribosome binding
I5Q59_RS15255	COG0085	RNA polymerase activity
I5Q59_RS15260	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I5Q59_RS15275	COG1196	nuclear chromosome segregation
I5Q59_RS15275	COG0741	lytic transglycosylase activity
I5Q59_RS15275	COG0739	heme binding
I5Q59_RS15300	COG1381	Involved in DNA repair and RecF pathway recombination
I5Q59_RS15340	COG2204	response regulator
I5Q59_RS15355	COG5002	protein histidine kinase activity
I5Q59_RS15360	COG0515	serine threonine protein kinase
I5Q59_RS15365	COG0752	glycyl-tRNA synthetase alpha subunit
I5Q59_RS15370	COG0751	glycine-tRNA ligase activity
I5Q59_RS15470	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I5Q59_RS15510	COG1505	serine-type exopeptidase activity
I5Q59_RS15575	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
I5Q59_RS15575	COG3608	succinylglutamate desuccinylase aspartoacylase
I5Q59_RS15590	COG2311	Membrane
I5Q59_RS15595	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I5Q59_RS15630	COG1272	protein, Hemolysin III
I5Q59_RS15650	COG3590	peptidase
I5Q59_RS15660	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I5Q59_RS15660	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I5Q59_RS15695	COG2354	Protein conserved in bacteria
I5Q59_RS15700	COG2130	NADP-dependent
I5Q59_RS15710	COG0330	HflC and HflK could
I5Q59_RS15730	COG1643	Atp-dependent helicase
I5Q59_RS15760	COG3064	Membrane
I5Q59_RS15760	COG4991	sh3 domain protein
I5Q59_RS15760	COG0515	serine threonine protein kinase
I5Q59_RS15765	COG2815	serine threonine protein kinase
I5Q59_RS15765	COG0515	serine threonine protein kinase
I5Q59_RS15780	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I5Q59_RS15790	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
I5Q59_RS15795	COG2921	Belongs to the UPF0250 family
I5Q59_RS15810	COG0443	Heat shock 70 kDa protein
I5Q59_RS15845	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I5Q59_RS15875	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I5Q59_RS15875	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I5Q59_RS15880	COG0425	Belongs to the sulfur carrier protein TusA family
I5Q59_RS15885	COG1131	(ABC) transporter
I5Q59_RS15895	COG0768	penicillin binding
I5Q59_RS15915	COG2204	response regulator
I5Q59_RS15920	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I5Q59_RS15940	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
I5Q59_RS15945	COG1605	Chorismate mutase
I5Q59_RS15945	COG0077	Prephenate dehydratase
I5Q59_RS15950	COG1605	Chorismate mutase
I5Q59_RS15950	COG0077	Prephenate dehydratase
I5Q59_RS15955	COG2153	protein acetylation
I5Q59_RS15985	COG0489	protein tyrosine kinase activity
I5Q59_RS15990	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I5Q59_RS15995	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I5Q59_RS16020	COG3088	subunit of a heme lyase
I5Q59_RS16025	COG3173	Aminoglycoside phosphotransferase
I5Q59_RS16035	COG2755	lipolytic protein G-D-S-L family
I5Q59_RS16035	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I5Q59_RS16050	COG5507	3-demethylubiquinone-9 3-methyltransferase
I5Q59_RS16100	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I5Q59_RS16105	COG1138	Cytochrome C-type biogenesis protein
I5Q59_RS16110	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
I5Q59_RS16130	COG1131	(ABC) transporter
I5Q59_RS16175	COG0352	thiamine-phosphate diphosphorylase activity
I5Q59_RS16180	COG2022	thiamine diphosphate biosynthetic process
I5Q59_RS16235	COG2267	carboxylic ester hydrolase activity
I5Q59_RS16240	COG0598	Magnesium transport protein CorA
I5Q59_RS16290	COG0018	arginyl-trna synthetase
I5Q59_RS16295	COG5002	protein histidine kinase activity
I5Q59_RS16320	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I5Q59_RS16325	COG0049	tRNA binding
I5Q59_RS16330	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I5Q59_RS16335	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I5Q59_RS16340	COG0051	transcription antitermination factor activity, RNA binding
I5Q59_RS16345	COG0088	Forms part of the polypeptide exit tunnel
I5Q59_RS16350	COG0089	rRNA binding
I5Q59_RS16355	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I5Q59_RS16360	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I5Q59_RS16365	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I5Q59_RS16370	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I5Q59_RS16375	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I5Q59_RS16380	COG0255	Belongs to the universal ribosomal protein uL29 family
I5Q59_RS16385	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I5Q59_RS16390	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I5Q59_RS16395	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I5Q59_RS16405	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I5Q59_RS16410	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I5Q59_RS16415	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I5Q59_RS16420	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I5Q59_RS16425	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I5Q59_RS16430	COG1841	ribosomal large subunit assembly
I5Q59_RS16435	COG0200	Binds to the 23S rRNA
I5Q59_RS16440	COG0201	protein transport
I5Q59_RS16445	COG0563	adenylate kinase activity
I5Q59_RS16450	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I5Q59_RS16455	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I5Q59_RS16460	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I5Q59_RS16465	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I5Q59_RS16470	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I5Q59_RS16475	COG0202	RNA polymerase activity
I5Q59_RS16480	COG0203	ribosomal protein L17
I5Q59_RS16520	COG2313	pseudouridylate synthase activity
I5Q59_RS16525	COG1956	GAF domain-containing protein
I5Q59_RS16540	COG0488	(ABC) transporter
I5Q59_RS16555	COG0741	lytic transglycosylase activity
I5Q59_RS16560	COG1278	Cold shock
I5Q59_RS16590	COG0564	pseudouridine synthase activity
I5Q59_RS16610	COG1297	OPT oligopeptide transporter protein
I5Q59_RS16615	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I5Q59_RS16630	COG0714	Associated with various cellular activities
I5Q59_RS16640	COG0741	lytic transglycosylase activity
I5Q59_RS16640	COG1196	nuclear chromosome segregation
I5Q59_RS16640	COG0739	heme binding
I5Q59_RS16670	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I5Q59_RS16715	COG1217	gtp-binding protein TYPA
I5Q59_RS16720	COG0596	Alpha beta hydrolase
I5Q59_RS16725	COG2204	response regulator
I5Q59_RS16740	COG0742	ribosomal rna small subunit methyltransferase
I5Q59_RS16745	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I5Q59_RS16750	COG0436	Aminotransferase
I5Q59_RS16760	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I5Q59_RS16765	COG1902	pentaerythritol trinitrate reductase activity
I5Q59_RS16800	COG0242	peptide deformylase activity
I5Q59_RS16855	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I5Q59_RS16860	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
I5Q59_RS16870	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I5Q59_RS16875	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I5Q59_RS16875	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I5Q59_RS16885	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I5Q59_RS16900	COG2217	Heavy metal translocating P-type atpase
I5Q59_RS16920	COG3852	Histidine kinase
I5Q59_RS16925	COG2132	Multicopper oxidase
I5Q59_RS16950	COG2132	Multicopper oxidase
I5Q59_RS16960	COG2217	Heavy metal translocating P-type atpase
I5Q59_RS17015	COG1058	Belongs to the CinA family
I5Q59_RS17015	COG1546	Belongs to the CinA family
I5Q59_RS17030	COG3590	peptidase
I5Q59_RS17080	COG0745	RESPONSE REGULATOR receiver
I5Q59_RS17085	COG5002	protein histidine kinase activity
I5Q59_RS17105	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I5Q59_RS17125	COG3791	Glutathione-dependent formaldehyde-activating
I5Q59_RS17130	COG0673	inositol 2-dehydrogenase activity
I5Q59_RS17135	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I5Q59_RS17155	COG2986	histidine ammonia-lyase
I5Q59_RS17160	COG0527	aspartate kinase activity
I5Q59_RS17185	COG1215	transferase activity, transferring glycosyl groups
I5Q59_RS17200	COG0210	DNA helicase
I5Q59_RS17205	COG0443	Heat shock 70 kDa protein
I5Q59_RS17235	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I5Q59_RS17235	COG2146	nitrite reductase [NAD(P)H] activity
I5Q59_RS17270	COG0529	Catalyzes the synthesis of activated sulfate
I5Q59_RS17275	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I5Q59_RS17295	COG3239	Fatty acid desaturase
I5Q59_RS17310	COG0617	tRNA 3'-terminal CCA addition
I5Q59_RS17315	COG0482	sulfurtransferase activity
I5Q59_RS17325	COG0776	regulation of translation
I5Q59_RS17360	COG0481	GTPase activity
I5Q59_RS17365	COG0681	Belongs to the peptidase S26 family
I5Q59_RS17370	COG0540	Belongs to the ATCase OTCase family
I5Q59_RS17380	COG0505	Belongs to the CarA family
I5Q59_RS17405	COG1022	Amp-dependent synthetase and ligase
I5Q59_RS17410	COG0372	Belongs to the citrate synthase family
I5Q59_RS17415	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I5Q59_RS17420	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I5Q59_RS17425	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I5Q59_RS17440	COG2226	methyltransferase
I5Q59_RS17445	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
I5Q59_RS17455	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
I5Q59_RS17470	COG4948	Mandelate Racemase Muconate Lactonizing
I5Q59_RS17505	COG0538	isocitrate dehydrogenase activity
I5Q59_RS17515	COG1053	succinate dehydrogenase
I5Q59_RS17520	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I5Q59_RS17525	COG0045	succinate-CoA ligase (ADP-forming) activity
I5Q59_RS17530	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I5Q59_RS17540	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I5Q59_RS17545	COG0228	four-way junction DNA binding
I5Q59_RS17550	COG1837	Belongs to the UPF0109 family
I5Q59_RS17555	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I5Q59_RS17560	COG0336	Belongs to the RNA methyltransferase TrmD family
I5Q59_RS17565	COG0335	large ribosomal subunit rRNA binding
I5Q59_RS17575	COG0792	nuclease activity
I5Q59_RS17580	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I5Q59_RS17595	COG2204	response regulator
I5Q59_RS17610	COG0728	peptidoglycan biosynthetic process
I5Q59_RS17640	COG1404	Belongs to the peptidase S8 family
I5Q59_RS17650	COG0154	amidase activity
I5Q59_RS17685	COG2255	four-way junction helicase activity
I5Q59_RS17690	COG4305	rare lipoprotein A
I5Q59_RS17695	COG2304	oxidoreductase activity
I5Q59_RS17715	COG1028	Short-chain dehydrogenase reductase Sdr
I5Q59_RS17735	COG1278	Cold shock
I5Q59_RS17745	COG0545	Peptidyl-prolyl cis-trans isomerase
I5Q59_RS17765	COG0628	permease
I5Q59_RS17780	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I5Q59_RS17785	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I5Q59_RS17790	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I5Q59_RS17795	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I5Q59_RS17800	COG0072	phenylalanine-tRNA ligase activity
I5Q59_RS17805	COG0776	regulation of translation
I5Q59_RS17815	COG0270	DNA (cytosine-5-)-methyltransferase activity
I5Q59_RS17830	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I5Q59_RS17860	COG4191	Histidine kinase
I5Q59_RS17865	COG3344	reverse transcriptase
I5Q59_RS17880	COG1484	DNA-dependent DNA replication
I5Q59_RS17885	COG4584	PFAM Integrase catalytic
I5Q59_RS17970	COG0438	transferase activity, transferring glycosyl groups
I5Q59_RS17985	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I5Q59_RS18025	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I5Q59_RS18035	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
I5Q59_RS18040	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I5Q59_RS18045	COG1535	isochorismatase
I5Q59_RS18045	COG3433	isochorismatase activity
I5Q59_RS18050	COG1021	2,3-dihydroxybenzoate-AMP ligase
I5Q59_RS18055	COG1169	isochorismate synthase
I5Q59_RS18060	COG1028	Short-chain dehydrogenase reductase Sdr
I5Q59_RS18075	COG1136	(ABC) transporter
I5Q59_RS18075	COG0577	efflux transmembrane transporter activity
I5Q59_RS18090	COG0277	FAD linked oxidase domain protein
I5Q59_RS18090	COG0247	lactate metabolic process
I5Q59_RS18095	COG0028	Belongs to the TPP enzyme family
I5Q59_RS18130	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I5Q59_RS18145	COG2076	Multidrug Resistance protein
I5Q59_RS18175	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I5Q59_RS18195	COG3227	Zinc metalloprotease (Elastase)
I5Q59_RS18225	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I5Q59_RS18240	COG0366	Alpha amylase catalytic
I5Q59_RS18280	COG0515	serine threonine protein kinase
I5Q59_RS18325	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I5Q59_RS18335	COG3706	GGDEF domain
I5Q59_RS18345	COG2136	Putative SAM-dependent methyltransferase
I5Q59_RS18345	COG2521	methyltransferase
I5Q59_RS18370	COG0612	Peptidase, M16
I5Q59_RS18380	COG0564	pseudouridine synthase activity
I5Q59_RS18395	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I5Q59_RS18405	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I5Q59_RS18430	COG0688	phosphatidylethanolamine metabolic process
I5Q59_RS18465	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I5Q59_RS18475	COG3781	membrane
I5Q59_RS18480	COG0745	RESPONSE REGULATOR receiver
I5Q59_RS18505	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I5Q59_RS18505	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I5Q59_RS18525	COG1830	Aldolase
I5Q59_RS18545	COG0456	acetyltransferase
I5Q59_RS18550	COG0156	8-amino-7-oxononanoate synthase activity
I5Q59_RS18575	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I5Q59_RS18580	COG3290	protein histidine kinase activity
I5Q59_RS18580	COG0840	transmembrane signaling receptor activity
I5Q59_RS18590	COG1024	Enoyl-CoA hydratase
I5Q59_RS18600	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I5Q59_RS18605	COG1960	acyl-CoA dehydrogenase activity
I5Q59_RS18615	COG0571	ribonuclease III activity
I5Q59_RS18630	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I5Q59_RS18635	COG1160	GTP binding
I5Q59_RS18680	COG0519	Catalyzes the synthesis of GMP from XMP
I5Q59_RS18690	COG0517	IMP dehydrogenase activity
I5Q59_RS18690	COG0516	GMP reductase activity
I5Q59_RS18695	COG0443	Heat shock 70 kDa protein
I5Q59_RS18710	COG0586	Pfam SNARE associated Golgi protein
I5Q59_RS18720	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I5Q59_RS18725	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I5Q59_RS18740	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I5Q59_RS18750	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I5Q59_RS18755	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I5Q59_RS18760	COG0183	Belongs to the thiolase family
I5Q59_RS18775	COG1960	acyl-CoA dehydrogenase activity
I5Q59_RS18780	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
I5Q59_RS18785	COG1960	acyl-CoA dehydrogenase activity
I5Q59_RS18795	COG1024	Enoyl-CoA hydratase
I5Q59_RS18800	COG1250	3-hydroxyacyl-CoA dehydrogenase
I5Q59_RS18815	COG0489	protein tyrosine kinase activity
I5Q59_RS18855	COG0430	RNA-3'-phosphate cyclase activity
I5Q59_RS18870	COG3852	Histidine kinase
I5Q59_RS18935	COG2165	general secretion pathway protein
I5Q59_RS18960	COG1946	Acyl-CoA thioesterase
I5Q59_RS18975	COG1047	Peptidyl-prolyl cis-trans
I5Q59_RS18980	COG3359	exonuclease
I5Q59_RS18985	COG1205	dead DEAH box helicase
I5Q59_RS18985	COG1111	helicase
I5Q59_RS18990	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I5Q59_RS19005	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I5Q59_RS19020	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I5Q59_RS19025	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I5Q59_RS19030	COG0180	Tryptophanyl-tRNA synthetase
I5Q59_RS19040	COG4974	Belongs to the 'phage' integrase family
I5Q59_RS19050	COG0009	L-threonylcarbamoyladenylate synthase
I5Q59_RS19055	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I5Q59_RS19055	COG0475	glutathione-regulated potassium exporter activity
I5Q59_RS19075	COG0398	Pfam SNARE associated Golgi protein
I5Q59_RS19105	COG0028	Belongs to the TPP enzyme family
I5Q59_RS19110	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I5Q59_RS19110	COG2111	Na H antiporter
I5Q59_RS19115	COG2111	Na H antiporter
I5Q59_RS19120	COG1006	Multisubunit Na H antiporter MnhC subunit
I5Q59_RS19125	COG0651	ATP synthesis coupled electron transport
I5Q59_RS19130	COG1863	multisubunit Na H antiporter MnhE subunit
I5Q59_RS19135	COG2212	antiporter activity
I5Q59_RS19140	COG1320	monovalent cation:proton antiporter activity
I5Q59_RS19155	COG1845	cytochrome c oxidase, subunit III
I5Q59_RS19160	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I5Q59_RS19160	COG1845	cytochrome c oxidase, subunit III
I5Q59_RS19165	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I5Q59_RS19195	COG0437	4 iron, 4 sulfur cluster binding
I5Q59_RS19205	COG1301	dicarboxylic acid transport
I5Q59_RS19215	COG4191	Histidine kinase
I5Q59_RS19215	COG0784	Response regulator, receiver
I5Q59_RS19220	COG2814	Major facilitator Superfamily
I5Q59_RS19225	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
I5Q59_RS19280	COG0110	maltose O-acetyltransferase activity
I5Q59_RS19290	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I5Q59_RS19305	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I5Q59_RS19310	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I5Q59_RS19355	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I5Q59_RS19365	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I5Q59_RS19370	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I5Q59_RS19370	COG1116	anion transmembrane transporter activity
I5Q59_RS19375	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I5Q59_RS19400	COG0067	glutamate synthase
I5Q59_RS19400	COG0070	glutamate synthase
I5Q59_RS19400	COG0069	glutamate synthase activity
I5Q59_RS19410	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I5Q59_RS19415	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
I5Q59_RS19425	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I5Q59_RS19450	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I5Q59_RS19455	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I5Q59_RS19470	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I5Q59_RS19475	COG2226	methyltransferase
I5Q59_RS19480	COG3321	synthase
I5Q59_RS19480	COG1028	Short-chain dehydrogenase reductase Sdr
I5Q59_RS19480	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I5Q59_RS19480	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I5Q59_RS19480	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I5Q59_RS19485	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I5Q59_RS19485	COG1028	Short-chain dehydrogenase reductase Sdr
I5Q59_RS19485	COG4221	oxidoreductase activity
I5Q59_RS19485	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I5Q59_RS19485	COG4221	oxidoreductase activity
I5Q59_RS19485	COG1028	Short-chain dehydrogenase reductase Sdr
I5Q59_RS19485	COG3321	synthase
I5Q59_RS19485	COG3321	synthase
I5Q59_RS19490	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I5Q59_RS19490	COG2070	2-Nitropropane dioxygenase
I5Q59_RS19495	COG4221	oxidoreductase activity
I5Q59_RS19495	COG3321	synthase
I5Q59_RS19495	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I5Q59_RS19495	COG0300	oxidoreductase activity
I5Q59_RS19500	COG3321	synthase
I5Q59_RS19500	COG4221	oxidoreductase activity
I5Q59_RS19500	COG0300	oxidoreductase activity
I5Q59_RS19500	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I5Q59_RS19510	COG1028	Short-chain dehydrogenase reductase Sdr
I5Q59_RS19510	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I5Q59_RS19510	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I5Q59_RS19510	COG3321	synthase
I5Q59_RS19510	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I5Q59_RS19515	COG1024	Enoyl-CoA hydratase
I5Q59_RS19520	COG1024	Enoyl-CoA hydratase
I5Q59_RS19525	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I5Q59_RS19535	COG2124	cytochrome p450
I5Q59_RS19540	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I5Q59_RS19545	COG3425	synthase
I5Q59_RS19550	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I5Q59_RS19560	COG3425	synthase
I5Q59_RS19565	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I5Q59_RS19610	COG0585	pseudouridine synthase activity
I5Q59_RS19635	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I5Q59_RS19645	COG1028	Short-chain dehydrogenase reductase Sdr
I5Q59_RS19670	COG0708	Exodeoxyribonuclease III
I5Q59_RS19750	COG0488	(ABC) transporter
I5Q59_RS19830	COG0667	Aldo Keto reductase
I5Q59_RS19910	COG2815	serine threonine protein kinase
I5Q59_RS19910	COG0515	serine threonine protein kinase
I5Q59_RS19955	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I5Q59_RS19995	COG0741	lytic transglycosylase activity
I5Q59_RS20010	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I5Q59_RS20015	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I5Q59_RS20020	COG0825	malonyl-CoA metabolic process
I5Q59_RS20055	COG2766	serine protein kinase
I5Q59_RS20060	COG0443	Heat shock 70 kDa protein
I5Q59_RS20065	COG0515	serine threonine protein kinase
I5Q59_RS20075	COG0495	leucyl-tRNA aminoacylation
I5Q59_RS20085	COG0515	serine threonine protein kinase
I5Q59_RS20085	COG2815	serine threonine protein kinase
I5Q59_RS20090	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I5Q59_RS20105	COG0101	tRNA pseudouridine synthase activity
I5Q59_RS20140	COG1606	tRNA processing
I5Q59_RS20145	COG0529	Catalyzes the synthesis of activated sulfate
I5Q59_RS20145	COG2046	Belongs to the sulfate adenylyltransferase family
I5Q59_RS20160	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
I5Q59_RS20180	COG4585	Histidine kinase
I5Q59_RS20195	COG1131	(ABC) transporter
I5Q59_RS20210	COG0604	alcohol dehydrogenase
I5Q59_RS20210	COG1028	Short-chain dehydrogenase reductase Sdr
I5Q59_RS20210	COG3321	synthase
I5Q59_RS20230	COG0513	Belongs to the DEAD box helicase family
I5Q59_RS20235	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I5Q59_RS20250	COG1408	metallophosphoesterase
I5Q59_RS20305	COG1181	Belongs to the D-alanine--D-alanine ligase family
I5Q59_RS20320	COG0113	porphobilinogen synthase activity
I5Q59_RS20330	COG1131	(ABC) transporter
I5Q59_RS20375	COG0583	DNA-binding transcription factor activity
I5Q59_RS20385	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I5Q59_RS20390	COG0668	transmembrane transport
I5Q59_RS20395	COG2133	pyrroloquinoline quinone binding
I5Q59_RS20405	COG3436	PFAM IS66 Orf2 family protein
I5Q59_RS20420	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I5Q59_RS20435	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I5Q59_RS20520	COG0745	RESPONSE REGULATOR receiver
I5Q59_RS20530	COG0686	Belongs to the AlaDH PNT family
I5Q59_RS20535	COG1595	DNA-templated transcription, initiation
I5Q59_RS20545	COG0745	RESPONSE REGULATOR receiver
I5Q59_RS20555	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
I5Q59_RS20560	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
I5Q59_RS20560	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
I5Q59_RS20590	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I5Q59_RS20600	COG3220	belongs to the UPF0276 family
I5Q59_RS20615	COG0745	RESPONSE REGULATOR receiver
I5Q59_RS20620	COG5002	protein histidine kinase activity
I5Q59_RS20660	COG1136	(ABC) transporter
I5Q59_RS20660	COG0577	efflux transmembrane transporter activity
I5Q59_RS20665	COG0577	efflux transmembrane transporter activity
I5Q59_RS20665	COG1136	(ABC) transporter
I5Q59_RS20670	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I5Q59_RS20685	COG0542	response to heat
I5Q59_RS20720	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I5Q59_RS20730	COG3876	Protein conserved in bacteria
I5Q59_RS20745	COG1193	negative regulation of DNA recombination
I5Q59_RS20770	COG2204	response regulator
I5Q59_RS20775	COG4191	Histidine kinase
I5Q59_RS20785	COG1136	(ABC) transporter
I5Q59_RS20790	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I5Q59_RS20795	COG0577	efflux transmembrane transporter activity
I5Q59_RS20795	COG1136	(ABC) transporter
I5Q59_RS20820	COG1028	Short-chain dehydrogenase reductase Sdr
I5Q59_RS20825	COG1408	metallophosphoesterase
I5Q59_RS20840	COG0557	exoribonuclease II activity
I5Q59_RS20850	COG0303	'Molybdopterin
I5Q59_RS20855	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I5Q59_RS20855	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I5Q59_RS20880	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I5Q59_RS20885	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I5Q59_RS20900	COG0140	phosphoribosyl-ATP diphosphatase activity
I5Q59_RS20900	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I5Q59_RS20910	COG0107	imidazoleglycerol-phosphate synthase activity
I5Q59_RS20915	COG0131	Imidazoleglycerol-phosphate dehydratase
I5Q59_RS20920	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
I5Q59_RS20925	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I5Q59_RS20930	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I5Q59_RS20940	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I5Q59_RS20945	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I5Q59_RS20945	COG2022	thiamine diphosphate biosynthetic process
I5Q59_RS20950	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
I5Q59_RS20950	COG2199	diguanylate cyclase activity
I5Q59_RS20965	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
I5Q59_RS20970	COG0517	IMP dehydrogenase activity
I5Q59_RS20970	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I5Q59_RS20970	COG0617	tRNA 3'-terminal CCA addition
I5Q59_RS20975	COG0471	metal ion transport
I5Q59_RS20985	COG2204	response regulator
I5Q59_RS21005	COG4191	Histidine kinase
I5Q59_RS21010	COG0745	RESPONSE REGULATOR receiver
I5Q59_RS21010	COG4566	intracellular signal transduction
I5Q59_RS21015	COG2205	protein histidine kinase activity
I5Q59_RS21035	COG3852	Histidine kinase
I5Q59_RS21085	COG2204	response regulator
I5Q59_RS21090	COG4191	Histidine kinase
I5Q59_RS21095	COG1309	transcriptional regulator
I5Q59_RS21100	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I5Q59_RS21115	COG3425	synthase
I5Q59_RS21120	COG0071	Belongs to the small heat shock protein (HSP20) family
I5Q59_RS21165	COG5640	endopeptidase activity
I5Q59_RS21175	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I5Q59_RS21235	COG0003	Pfam Anion-transporting ATPase
I5Q59_RS21275	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I5Q59_RS21285	COG1960	acyl-CoA dehydrogenase activity
I5Q59_RS21290	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I5Q59_RS21330	COG0737	Belongs to the 5'-nucleotidase family
I5Q59_RS21360	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I5Q59_RS21370	COG0730	response to heat
I5Q59_RS21410	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I5Q59_RS21430	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I5Q59_RS21460	COG0515	serine threonine protein kinase
I5Q59_RS21470	COG2204	response regulator
I5Q59_RS21490	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
I5Q59_RS21500	COG1228	amidohydrolase
I5Q59_RS21505	COG0121	glutamine amidotransferase
I5Q59_RS21515	COG0802	atpase or kinase
I5Q59_RS21520	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I5Q59_RS21520	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I5Q59_RS21525	COG0736	holo-[acyl-carrier-protein] synthase activity
I5Q59_RS21530	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I5Q59_RS21535	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I5Q59_RS21540	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I5Q59_RS21550	COG2353	YceI-like domain
I5Q59_RS21555	COG0583	DNA-binding transcription factor activity
I5Q59_RS21560	COG1741	Belongs to the pirin family
I5Q59_RS21565	COG1741	Belongs to the pirin family
I5Q59_RS21570	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I5Q59_RS21575	COG0037	tRNA processing
I5Q59_RS21615	COG2226	methyltransferase
I5Q59_RS21625	COG0515	serine threonine protein kinase
I5Q59_RS21625	COG2815	serine threonine protein kinase
I5Q59_RS21635	COG0515	serine threonine protein kinase
I5Q59_RS21695	COG3246	L-lysine catabolic process to acetate
I5Q59_RS21700	COG1607	acyl-coa hydrolase
I5Q59_RS21705	COG5012	cobalamin binding
I5Q59_RS21715	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
I5Q59_RS21720	COG0753	catalase activity
I5Q59_RS21730	COG0604	alcohol dehydrogenase
I5Q59_RS21740	COG1573	uracil-dna glycosylase
I5Q59_RS21750	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I5Q59_RS21765	COG0631	protein serine/threonine phosphatase activity
I5Q59_RS21815	COG0318	PFAM AMP-dependent synthetase and ligase
I5Q59_RS21820	COG1742	UPF0060 membrane protein
I5Q59_RS21850	COG2264	protein methyltransferase activity
I5Q59_RS21900	COG2119	membrane
I5Q59_RS21925	COG4464	protein tyrosine phosphatase activity
I5Q59_RS21930	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
I5Q59_RS21945	COG0010	Belongs to the arginase family
I5Q59_RS21955	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I5Q59_RS21960	COG2815	serine threonine protein kinase
I5Q59_RS21960	COG0515	serine threonine protein kinase
I5Q59_RS21965	COG3268	Saccharopine dehydrogenase
I5Q59_RS21980	COG0745	RESPONSE REGULATOR receiver
I5Q59_RS22015	COG5002	protein histidine kinase activity
I5Q59_RS22020	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I5Q59_RS22035	COG0739	heme binding
I5Q59_RS22040	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
I5Q59_RS22045	COG0148	phosphopyruvate hydratase activity
I5Q59_RS22065	COG1494	fructose-1,6-bisphosphatase
I5Q59_RS22070	COG0824	Thioesterase
I5Q59_RS22075	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
I5Q59_RS22085	COG0525	valine-tRNA ligase activity
I5Q59_RS22100	COG3706	GGDEF domain
I5Q59_RS22110	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5Q59_RS22110	COG2205	protein histidine kinase activity
I5Q59_RS22120	COG0459	protein refolding
I5Q59_RS22185	COG2815	serine threonine protein kinase
I5Q59_RS22185	COG0515	serine threonine protein kinase
I5Q59_RS22335	COG1222	aaa ATPase
I5Q59_RS22375	COG3119	arylsulfatase activity
I5Q59_RS22395	COG1028	Short-chain dehydrogenase reductase Sdr
I5Q59_RS22395	COG3321	synthase
I5Q59_RS22395	COG0604	alcohol dehydrogenase
I5Q59_RS22485	COG1032	radical SAM domain protein
I5Q59_RS22510	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I5Q59_RS22545	COG0515	serine threonine protein kinase
I5Q59_RS22555	COG4771	TonB-dependent receptor
I5Q59_RS22570	COG2770	Histidine kinase
I5Q59_RS22570	COG2208	phosphoserine phosphatase activity
I5Q59_RS22585	COG0022	dehydrogenase e1 component
I5Q59_RS22645	COG0045	succinate-CoA ligase (ADP-forming) activity
I5Q59_RS22645	COG1042	CoA-binding domain protein
I5Q59_RS22645	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I5Q59_RS22670	COG2885	chlorophyll binding
I5Q59_RS22685	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
I5Q59_RS22685	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I5Q59_RS22695	COG0488	(ABC) transporter
I5Q59_RS22705	COG1295	ribonuclease BN
I5Q59_RS22730	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I5Q59_RS22750	COG1032	radical SAM domain protein
I5Q59_RS22810	COG0477	Major facilitator Superfamily
I5Q59_RS22845	COG1216	Glycosyl transferase, family 2
I5Q59_RS22850	COG0463	Glycosyl transferase, family 2
I5Q59_RS22860	COG1215	transferase activity, transferring glycosyl groups
I5Q59_RS22905	COG0741	lytic transglycosylase activity
I5Q59_RS22930	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I5Q59_RS22975	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
I5Q59_RS22980	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I5Q59_RS23000	COG1570	exodeoxyribonuclease VII activity
I5Q59_RS23085	COG4608	Belongs to the ABC transporter superfamily
I5Q59_RS23090	COG0444	Belongs to the ABC transporter superfamily
I5Q59_RS23095	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I5Q59_RS23110	COG0811	peptide transport
I5Q59_RS23120	COG1960	acyl-CoA dehydrogenase activity
I5Q59_RS23130	COG2030	dehydratase
I5Q59_RS23145	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I5Q59_RS23155	COG0714	Associated with various cellular activities
I5Q59_RS23165	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I5Q59_RS23170	COG1193	negative regulation of DNA recombination
I5Q59_RS23210	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I5Q59_RS23210	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
I5Q59_RS23220	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I5Q59_RS23225	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I5Q59_RS23230	COG1862	Preprotein translocase
I5Q59_RS23235	COG0343	queuine tRNA-ribosyltransferase activity
I5Q59_RS23240	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I5Q59_RS23245	COG2385	sporulation resulting in formation of a cellular spore
I5Q59_RS23265	COG1509	lysine 2,3-aminomutase activity
I5Q59_RS23275	COG0515	serine threonine protein kinase
I5Q59_RS23300	COG0194	GDP metabolic process
I5Q59_RS23305	COG1561	YicC-like family, N-terminal region
I5Q59_RS23315	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I5Q59_RS23315	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
I5Q59_RS23325	COG1663	tetraacyldisaccharide 4'-kinase activity
I5Q59_RS23350	COG1132	(ABC) transporter
I5Q59_RS23360	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I5Q59_RS23370	COG2095	MarC family integral membrane protein
I5Q59_RS23390	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I5Q59_RS23395	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I5Q59_RS23400	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I5Q59_RS23410	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I5Q59_RS23415	COG1136	(ABC) transporter
I5Q59_RS23425	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I5Q59_RS23435	COG1595	DNA-templated transcription, initiation
I5Q59_RS23450	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I5Q59_RS23450	COG0662	Cupin 2, conserved barrel domain protein
I5Q59_RS23455	COG1480	7TM receptor with intracellular HD hydrolase
I5Q59_RS23475	COG3956	TIGRFAM MazG family protein
I5Q59_RS23480	COG0268	Binds directly to 16S ribosomal RNA
I5Q59_RS23495	COG0495	leucyl-tRNA aminoacylation
I5Q59_RS23500	COG4771	TonB-dependent receptor
I5Q59_RS23510	COG2084	Dehydrogenase
I5Q59_RS23520	COG1131	(ABC) transporter
I5Q59_RS23525	COG0745	RESPONSE REGULATOR receiver
I5Q59_RS23530	COG2201	protein-glutamate methylesterase activity
I5Q59_RS23535	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I5Q59_RS23550	COG0835	chemotaxis
I5Q59_RS23560	COG0643	Histidine kinase
I5Q59_RS23560	COG0643	Histidine kinase
I5Q59_RS23560	COG0784	Response regulator, receiver
I5Q59_RS23560	COG2198	Histidine kinase
I5Q59_RS23560	COG2198	Histidine kinase
I5Q59_RS23560	COG0784	Response regulator, receiver
I5Q59_RS23565	COG0745	RESPONSE REGULATOR receiver
I5Q59_RS23575	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I5Q59_RS23580	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I5Q59_RS23590	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I5Q59_RS23590	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I5Q59_RS23595	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I5Q59_RS23600	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I5Q59_RS23605	COG0698	ribose 5-phosphate isomerase
I5Q59_RS23610	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I5Q59_RS23615	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I5Q59_RS23620	COG1028	Short-chain dehydrogenase reductase Sdr
I5Q59_RS23625	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I5Q59_RS23630	COG0416	fatty acid biosynthetic process
I5Q59_RS23635	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I5Q59_RS23640	COG1399	metal-binding, possibly nucleic acid-binding protein
I5Q59_RS23655	COG0745	RESPONSE REGULATOR receiver
I5Q59_RS23660	COG5002	protein histidine kinase activity
I5Q59_RS23670	COG2062	phosphohistidine phosphatase, SixA
I5Q59_RS23680	COG0730	response to heat
I5Q59_RS23690	COG0659	secondary active sulfate transmembrane transporter activity
I5Q59_RS23695	COG2204	response regulator
I5Q59_RS23700	COG5002	protein histidine kinase activity
I5Q59_RS23705	COG0745	RESPONSE REGULATOR receiver
I5Q59_RS23715	COG0573	inorganic phosphate transmembrane transporter activity
I5Q59_RS23720	COG0581	inorganic phosphate transmembrane transporter activity
I5Q59_RS23725	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I5Q59_RS23740	COG0745	RESPONSE REGULATOR receiver
I5Q59_RS23745	COG1253	flavin adenine dinucleotide binding
I5Q59_RS23765	COG3047	cAMP biosynthetic process
I5Q59_RS23765	COG2885	chlorophyll binding
I5Q59_RS23815	COG3157	Type VI secretion system effector, Hcp
I5Q59_RS23860	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I5Q59_RS23865	COG4208	sulfate ABC transporter
I5Q59_RS23880	COG0542	response to heat
I5Q59_RS23900	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I5Q59_RS23920	COG0542	response to heat
I5Q59_RS23935	COG0477	Major facilitator Superfamily
I5Q59_RS23945	COG0154	amidase activity
I5Q59_RS23950	COG0514	ATP-dependent DNA helicase (RecQ)
I5Q59_RS23960	COG0515	serine threonine protein kinase
I5Q59_RS24030	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I5Q59_RS24110	COG1324	tolerance protein
I5Q59_RS24130	COG0527	aspartate kinase activity
I5Q59_RS24180	COG2223	nitrite transmembrane transporter activity
I5Q59_RS24195	COG1758	RNA polymerase activity
I5Q59_RS24215	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I5Q59_RS24220	COG0459	protein refolding
I5Q59_RS24240	COG3829	transcription factor binding
I5Q59_RS24250	COG1196	nuclear chromosome segregation
I5Q59_RS24255	COG1253	flavin adenine dinucleotide binding
I5Q59_RS24265	COG2843	Capsule synthesis protein
I5Q59_RS24270	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I5Q59_RS24275	COG2890	protein-(glutamine-N5) methyltransferase activity
I5Q59_RS24280	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I5Q59_RS24330	COG2124	cytochrome p450
I5Q59_RS24355	COG2264	protein methyltransferase activity
I5Q59_RS24385	COG1231	oxidoreductase activity
I5Q59_RS24470	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I5Q59_RS24505	COG3220	belongs to the UPF0276 family
I5Q59_RS24520	COG3800	Transcriptional regulator
I5Q59_RS24520	COG1396	sequence-specific DNA binding
I5Q59_RS24535	COG0730	response to heat
I5Q59_RS24545	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I5Q59_RS24560	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I5Q59_RS24560	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I5Q59_RS24565	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
I5Q59_RS24575	COG2255	four-way junction helicase activity
I5Q59_RS24590	COG0632	four-way junction helicase activity
I5Q59_RS24595	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
I5Q59_RS24600	COG0217	transcriptional regulatory protein
I5Q59_RS24615	COG2204	response regulator
I5Q59_RS24630	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I5Q59_RS24635	COG0430	RNA-3'-phosphate cyclase activity
I5Q59_RS24640	COG1690	Belongs to the RtcB family
I5Q59_RS24645	COG4650	regulator
I5Q59_RS24665	COG3852	Histidine kinase
I5Q59_RS24715	COG3011	Protein conserved in bacteria
I5Q59_RS24730	COG1104	cysteine desulfurase activity
I5Q59_RS24735	COG0822	iron-sulfur transferase activity
I5Q59_RS24740	COG0316	Belongs to the HesB IscA family
I5Q59_RS24755	COG0633	Ferredoxin
I5Q59_RS24840	COG1304	FMN binding
I5Q59_RS24870	COG0501	Belongs to the peptidase M48B family
I5Q59_RS24880	COG1846	Transcriptional regulator
I5Q59_RS24905	COG5002	protein histidine kinase activity
I5Q59_RS24910	COG0612	Peptidase, M16
I5Q59_RS24935	COG1012	belongs to the aldehyde dehydrogenase family
I5Q59_RS24940	COG3284	Transcriptional regulator
I5Q59_RS24945	COG2885	chlorophyll binding
I5Q59_RS24960	COG0515	serine threonine protein kinase
I5Q59_RS24960	COG0457	Tetratricopeptide repeat
I5Q59_RS24975	COG2204	response regulator
I5Q59_RS24990	COG0745	RESPONSE REGULATOR receiver
I5Q59_RS25020	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I5Q59_RS25085	COG1280	lysine exporter protein (LysE YggA)
I5Q59_RS25090	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I5Q59_RS25100	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I5Q59_RS25105	COG1435	thymidine kinase activity
I5Q59_RS25115	COG2088	sporulation resulting in formation of a cellular spore
I5Q59_RS25120	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I5Q59_RS25125	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I5Q59_RS25130	COG0193	aminoacyl-tRNA hydrolase activity
I5Q59_RS25135	COG0360	Binds together with S18 to 16S ribosomal RNA
I5Q59_RS25140	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I5Q59_RS25145	COG0359	binds to the 23S rRNA
I5Q59_RS25155	COG3275	phosphorelay sensor kinase activity
I5Q59_RS25160	COG3279	Response regulator of the LytR AlgR family
I5Q59_RS25170	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I5Q59_RS25170	COG0351	phosphomethylpyrimidine kinase
I5Q59_RS25170	COG0352	thiamine-phosphate diphosphorylase activity
I5Q59_RS25175	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I5Q59_RS25180	COG0352	thiamine-phosphate diphosphorylase activity
I5Q59_RS25205	COG0542	response to heat
I5Q59_RS25215	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I5Q59_RS25225	COG2311	Membrane
I5Q59_RS25240	COG1733	regulation of RNA biosynthetic process
I5Q59_RS25245	COG0702	epimerase
I5Q59_RS25260	COG1438	arginine binding
I5Q59_RS25265	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I5Q59_RS25270	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I5Q59_RS25280	COG0165	Argininosuccinate lyase
I5Q59_RS25285	COG0137	argininosuccinate synthase activity
I5Q59_RS25295	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I5Q59_RS25325	COG0515	serine threonine protein kinase
I5Q59_RS25345	COG0789	Transcriptional regulator
I5Q59_RS25360	COG5002	protein histidine kinase activity
I5Q59_RS25365	COG2204	response regulator
I5Q59_RS25370	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I5Q59_RS25380	COG3186	Phenylalanine-4-hydroxylase
I5Q59_RS25415	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I5Q59_RS25420	COG0183	Belongs to the thiolase family
I5Q59_RS25425	COG1250	3-hydroxyacyl-CoA dehydrogenase
I5Q59_RS25425	COG1024	Enoyl-CoA hydratase
I5Q59_RS25440	COG0254	rRNA binding
I5Q59_RS25455	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I5Q59_RS25460	COG2201	protein-glutamate methylesterase activity
I5Q59_RS25500	COG2885	chlorophyll binding
I5Q59_RS25505	COG2204	response regulator
I5Q59_RS25540	COG0443	Heat shock 70 kDa protein
I5Q59_RS25550	COG2135	peptidase activity
I5Q59_RS25565	COG0232	Belongs to the dGTPase family. Type 2 subfamily
I5Q59_RS25585	COG1132	(ABC) transporter
I5Q59_RS25590	COG0577	efflux transmembrane transporter activity
I5Q59_RS25610	COG0641	radical SAM
I5Q59_RS25630	COG2815	serine threonine protein kinase
I5Q59_RS25630	COG0515	serine threonine protein kinase
I5Q59_RS25665	COG5000	phosphorelay sensor kinase activity
I5Q59_RS25715	COG3047	cAMP biosynthetic process
I5Q59_RS25715	COG2885	chlorophyll binding
I5Q59_RS25730	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I5Q59_RS25730	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I5Q59_RS25735	COG0252	asparaginase activity
I5Q59_RS25785	COG1028	Short-chain dehydrogenase reductase Sdr
I5Q59_RS25795	COG1309	transcriptional regulator
I5Q59_RS25805	COG0745	RESPONSE REGULATOR receiver
I5Q59_RS25820	COG3344	reverse transcriptase
I5Q59_RS25840	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I5Q59_RS25855	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I5Q59_RS25860	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I5Q59_RS25865	COG1053	succinate dehydrogenase
I5Q59_RS25885	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I5Q59_RS25890	COG0513	Belongs to the DEAD box helicase family
I5Q59_RS25900	COG0564	pseudouridine synthase activity
I5Q59_RS25925	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I5Q59_RS25935	COG3942	CHAP domain
I5Q59_RS25935	COG1388	LysM domain
I5Q59_RS25950	COG3059	membrane
I5Q59_RS25985	COG0412	Dienelactone hydrolase
I5Q59_RS26095	COG2375	cellular response to nickel ion
I5Q59_RS26095	COG1132	(ABC) transporter
I5Q59_RS26100	COG1132	(ABC) transporter
I5Q59_RS26160	COG3485	protocatechuate 3,4-dioxygenase
I5Q59_RS26165	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I5Q59_RS26225	COG2909	trisaccharide binding
I5Q59_RS26255	COG1278	Cold shock
I5Q59_RS26275	COG2205	protein histidine kinase activity
I5Q59_RS26290	COG1131	(ABC) transporter
I5Q59_RS26295	COG0109	protoheme IX farnesyltransferase activity
I5Q59_RS26315	COG0443	Heat shock 70 kDa protein
I5Q59_RS26320	COG0443	Heat shock 70 kDa protein
I5Q59_RS26330	COG0737	Belongs to the 5'-nucleotidase family
I5Q59_RS26385	COG0543	2 iron, 2 sulfur cluster binding
I5Q59_RS26385	COG0493	'glutamate synthase
I5Q59_RS26395	COG2062	phosphohistidine phosphatase, SixA
I5Q59_RS26410	COG0233	cytoplasmic translational termination
I5Q59_RS26415	COG0528	UMP kinase activity
I5Q59_RS26420	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I5Q59_RS26425	COG0052	Belongs to the universal ribosomal protein uS2 family
I5Q59_RS26430	COG0653	protein targeting
I5Q59_RS26435	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
I5Q59_RS26445	COG0739	heme binding
I5Q59_RS26450	COG0631	protein serine/threonine phosphatase activity
I5Q59_RS26455	COG0497	DNA recombination
I5Q59_RS26460	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I5Q59_RS26465	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I5Q59_RS26490	COG2814	Major facilitator Superfamily
I5Q59_RS26495	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I5Q59_RS26505	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I5Q59_RS26520	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I5Q59_RS26540	COG1215	transferase activity, transferring glycosyl groups
I5Q59_RS26545	COG3394	polysaccharide catabolic process
I5Q59_RS26560	COG1250	3-hydroxyacyl-CoA dehydrogenase
I5Q59_RS26560	COG1024	Enoyl-CoA hydratase
I5Q59_RS26565	COG0183	Belongs to the thiolase family
I5Q59_RS26570	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I5Q59_RS26575	COG1874	Beta-galactosidase
I5Q59_RS26575	COG0366	Alpha amylase catalytic
I5Q59_RS26590	COG3842	ATPase activity
I5Q59_RS26595	COG1175	transmembrane transport
I5Q59_RS26675	COG5640	endopeptidase activity
I5Q59_RS26735	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
I5Q59_RS26750	COG4941	Belongs to the sigma-70 factor family
I5Q59_RS26760	COG0501	Belongs to the peptidase M48B family
I5Q59_RS26790	COG1051	belongs to the nudix hydrolase family
I5Q59_RS26805	COG0590	tRNA wobble adenosine to inosine editing
I5Q59_RS26870	COG2801	Transposase and inactivated derivatives
I5Q59_RS26900	COG3227	Zinc metalloprotease (Elastase)
I5Q59_RS26980	COG1505	serine-type exopeptidase activity
I5Q59_RS26995	COG0429	hydrolase of the alpha beta-hydrolase fold
I5Q59_RS27060	COG0612	Peptidase, M16
I5Q59_RS27070	COG1652	LysM domain
I5Q59_RS27085	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
I5Q59_RS27090	COG3973	AAA domain
I5Q59_RS27125	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
I5Q59_RS27140	COG0583	DNA-binding transcription factor activity
I5Q59_RS27145	COG4249	Peptidase C14 caspase catalytic subunit p20
I5Q59_RS27145	COG2319	Wd-40 repeat
I5Q59_RS27190	COG1126	abc transporter atp-binding protein
I5Q59_RS27195	COG0765	amino acid transport
I5Q59_RS27205	COG0745	RESPONSE REGULATOR receiver
I5Q59_RS27230	COG1032	radical SAM domain protein
I5Q59_RS27290	COG5380	lipid catabolic process
I5Q59_RS27305	COG1671	Belongs to the UPF0178 family
I5Q59_RS27320	COG0588	phosphoglycerate mutase activity
I5Q59_RS27335	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I5Q59_RS27375	COG3278	Belongs to the heme-copper respiratory oxidase family
I5Q59_RS27395	COG1309	transcriptional regulator
I5Q59_RS27405	COG1309	transcriptional regulator
I5Q59_RS27425	COG0653	protein targeting
I5Q59_RS27430	COG0673	inositol 2-dehydrogenase activity
I5Q59_RS27455	COG0437	4 iron, 4 sulfur cluster binding
I5Q59_RS27480	COG1858	cytochrome C peroxidase
I5Q59_RS27495	COG3030	protein affecting phage T7 exclusion by the F plasmid
I5Q59_RS27505	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I5Q59_RS27515	COG1929	Belongs to the glycerate kinase type-1 family
I5Q59_RS27540	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I5Q59_RS27560	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
I5Q59_RS27620	COG0745	RESPONSE REGULATOR receiver
I5Q59_RS27625	COG1024	Enoyl-CoA hydratase
I5Q59_RS27640	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I5Q59_RS27655	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I5Q59_RS27660	COG1181	Belongs to the D-alanine--D-alanine ligase family
I5Q59_RS27665	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I5Q59_RS27670	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I5Q59_RS27675	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I5Q59_RS27685	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I5Q59_RS27690	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I5Q59_RS27695	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I5Q59_RS27700	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I5Q59_RS27710	COG3116	cell division
I5Q59_RS27715	COG0275	rRNA processing
I5Q59_RS27725	COG2001	Belongs to the MraZ family
I5Q59_RS27735	COG1960	acyl-CoA dehydrogenase activity
I5Q59_RS27755	COG0515	serine threonine protein kinase
I5Q59_RS27810	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I5Q59_RS27810	COG0519	Catalyzes the synthesis of GMP from XMP
I5Q59_RS27825	COG0628	permease
I5Q59_RS27835	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I5Q59_RS27840	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I5Q59_RS27845	COG1254	Belongs to the acylphosphatase family
I5Q59_RS27860	COG1295	ribonuclease BN
I5Q59_RS27875	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I5Q59_RS27885	COG1987	bacterial-type flagellum assembly
I5Q59_RS27910	COG4669	(LipO)protein
I5Q59_RS27930	COG0745	RESPONSE REGULATOR receiver
I5Q59_RS27960	COG2304	oxidoreductase activity
I5Q59_RS27980	COG0714	Associated with various cellular activities
I5Q59_RS27985	COG2267	carboxylic ester hydrolase activity
I5Q59_RS27995	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I5Q59_RS28005	COG2204	response regulator
I5Q59_RS28020	COG4968	Prepilin-type N-terminal cleavage methylation domain
I5Q59_RS28050	COG2204	response regulator
I5Q59_RS28085	COG0668	transmembrane transport
I5Q59_RS28095	COG0737	Belongs to the 5'-nucleotidase family
I5Q59_RS28100	COG1388	LysM domain
I5Q59_RS28100	COG0741	lytic transglycosylase activity
I5Q59_RS28130	COG0515	serine threonine protein kinase
I5Q59_RS28145	COG1136	(ABC) transporter
I5Q59_RS28175	COG0402	S-adenosylhomocysteine deaminase activity
I5Q59_RS28180	COG0295	cytidine deaminase activity
I5Q59_RS28205	COG1744	ABC transporter substrate-binding protein PnrA-like
I5Q59_RS28210	COG3845	ABC transporter
I5Q59_RS28215	COG4603	Belongs to the binding-protein-dependent transport system permease family
I5Q59_RS28220	COG1079	Belongs to the binding-protein-dependent transport system permease family
I5Q59_RS28225	COG4191	Histidine kinase
I5Q59_RS28235	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I5Q59_RS28245	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
I5Q59_RS28250	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I5Q59_RS28305	COG4941	Belongs to the sigma-70 factor family
I5Q59_RS28325	COG0552	protein localization to endoplasmic reticulum
I5Q59_RS28350	COG1215	transferase activity, transferring glycosyl groups
I5Q59_RS28355	COG1181	Belongs to the D-alanine--D-alanine ligase family
I5Q59_RS28370	COG0793	Belongs to the peptidase S41A family
I5Q59_RS28375	COG0508	dehydrogenase complex catalyzes the overall conversion of
I5Q59_RS28375	COG0596	Alpha beta hydrolase
I5Q59_RS28385	COG2177	Part of the ABC transporter FtsEX involved in
I5Q59_RS28390	COG2884	Cell division ATP-binding protein ftsE
I5Q59_RS28405	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I5Q59_RS28415	COG0811	peptide transport
I5Q59_RS28430	COG0823	Involved in the tonB-independent uptake of proteins
I5Q59_RS28450	COG2814	Major facilitator Superfamily
I5Q59_RS28465	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I5Q59_RS28475	COG3267	Type II secretory pathway component ExeA
I5Q59_RS28475	COG3409	Peptidoglycan-binding domain 1 protein
I5Q59_RS28485	COG0439	Biotin carboxylase
I5Q59_RS28490	COG0511	ligase activity, forming carbon-carbon bonds
I5Q59_RS28495	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I5Q59_RS28535	COG2204	response regulator
I5Q59_RS28540	COG3852	Histidine kinase
I5Q59_RS28545	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
I5Q59_RS28555	COG1131	(ABC) transporter
I5Q59_RS28565	COG4968	Prepilin-type N-terminal cleavage methylation domain
I5Q59_RS28575	COG3852	Histidine kinase
I5Q59_RS28580	COG1459	type II secretion system
I5Q59_RS28590	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I5Q59_RS28600	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I5Q59_RS28625	COG1199	ATP-dependent helicase activity
I5Q59_RS28660	COG1858	cytochrome C peroxidase
I5Q59_RS28665	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I5Q59_RS28680	COG0443	Heat shock 70 kDa protein
I5Q59_RS28690	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
I5Q59_RS28700	COG0793	Belongs to the peptidase S41A family
I5Q59_RS28710	COG0584	glycerophosphoryl diester phosphodiesterase
I5Q59_RS28715	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I5Q59_RS28735	COG1192	Involved in chromosome partitioning
I5Q59_RS28750	COG0003	Pfam Anion-transporting ATPase
I5Q59_RS28775	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I5Q59_RS28790	COG2766	serine protein kinase
I5Q59_RS28795	COG2718	Belongs to the UPF0229 family
I5Q59_RS28800	COG2719	SpoVR family
I5Q59_RS28805	COG0739	heme binding
I5Q59_RS28815	COG0058	SHG alpha-glucan phosphorylase activity
I5Q59_RS28840	COG1028	Short-chain dehydrogenase reductase Sdr
I5Q59_RS28845	COG0826	peptidase U32
I5Q59_RS28855	COG1024	Enoyl-CoA hydratase
I5Q59_RS28870	COG0587	DNA-directed DNA polymerase activity
I5Q59_RS28935	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I5Q59_RS28945	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I5Q59_RS28950	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I5Q59_RS28955	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I5Q59_RS28955	COG3453	Protein conserved in bacteria
I5Q59_RS28965	COG2032	superoxide dismutase activity
I5Q59_RS29020	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I5Q59_RS29025	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I5Q59_RS29040	COG2353	YceI-like domain
I5Q59_RS29045	COG3384	dioxygenase
I5Q59_RS29070	COG0183	Belongs to the thiolase family
I5Q59_RS29105	COG3189	MarR family transcriptional regulator
I5Q59_RS29115	COG1012	belongs to the aldehyde dehydrogenase family
I5Q59_RS29125	COG2826	transposase and inactivated derivatives, IS30 family
I5Q59_RS29155	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I5Q59_RS29155	COG2169	Transcriptional regulator
I5Q59_RS29165	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I5Q59_RS29175	COG0805	protein transport
I5Q59_RS29175	COG0805	protein transport
I5Q59_RS29180	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I5Q59_RS29190	COG0840	transmembrane signaling receptor activity
I5Q59_RS29195	COG0123	including yeast histone deacetylase and acetoin utilization protein
I5Q59_RS29200	COG0300	oxidoreductase activity
I5Q59_RS29205	COG0284	orotidine-5'-phosphate decarboxylase activity
I5Q59_RS29215	COG0564	pseudouridine synthase activity
I5Q59_RS29230	COG1793	dna ligase
I5Q59_RS29230	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
I5Q59_RS29255	COG2086	electron transfer activity
I5Q59_RS29260	COG1960	acyl-CoA dehydrogenase activity
I5Q59_RS29265	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I5Q59_RS29270	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I5Q59_RS29270	COG0517	IMP dehydrogenase activity
I5Q59_RS29285	COG0179	Fumarylacetoacetate (FAA) hydrolase
I5Q59_RS29290	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I5Q59_RS29295	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I5Q59_RS29300	COG0019	diaminopimelate decarboxylase activity
I5Q59_RS29320	COG4783	chaperone-mediated protein folding
I5Q59_RS29325	COG1295	ribonuclease BN
I5Q59_RS29330	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
I5Q59_RS29355	COG0697	spore germination
I5Q59_RS29365	COG2096	Adenosyltransferase
I5Q59_RS29370	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I5Q59_RS29405	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I5Q59_RS29410	COG1078	dGTPase activity
I5Q59_RS29415	COG1181	Belongs to the D-alanine--D-alanine ligase family
I5Q59_RS29430	COG1331	Highly conserved protein containing a thioredoxin domain
I5Q59_RS29440	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I5Q59_RS29515	COG0187	DNA topoisomerase II activity
I5Q59_RS29530	COG0596	Alpha beta hydrolase
I5Q59_RS29530	COG0508	dehydrogenase complex catalyzes the overall conversion of
I5Q59_RS29540	COG0515	serine threonine protein kinase
I5Q59_RS29560	COG0037	tRNA processing
I5Q59_RS29570	COG0308	aminopeptidase N
I5Q59_RS29600	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
I5Q59_RS29610	COG2205	protein histidine kinase activity
I5Q59_RS29620	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I5Q59_RS29625	COG0251	oxidation-reduction process
I5Q59_RS29640	COG0642	Histidine kinase
I5Q59_RS29660	COG4607	ABC-type enterochelin transport system periplasmic component
I5Q59_RS29675	COG1131	(ABC) transporter
I5Q59_RS29680	COG2264	protein methyltransferase activity
I5Q59_RS29695	COG4377	Putative membrane peptidase family (DUF2324)
I5Q59_RS29715	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I5Q59_RS29720	COG2201	protein-glutamate methylesterase activity
I5Q59_RS29730	COG4191	Histidine kinase
I5Q59_RS29735	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I5Q59_RS29780	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I5Q59_RS29785	COG0542	response to heat
I5Q59_RS29795	COG2201	protein-glutamate methylesterase activity
I5Q59_RS29820	COG2205	protein histidine kinase activity
I5Q59_RS29820	COG0784	Response regulator, receiver
I5Q59_RS29820	COG2198	Histidine kinase
I5Q59_RS29825	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I5Q59_RS29835	COG0508	dehydrogenase complex catalyzes the overall conversion of
I5Q59_RS29840	COG1278	Cold shock
I5Q59_RS29860	COG1404	Belongs to the peptidase S8 family
I5Q59_RS29860	COG4935	Belongs to the peptidase S8 family
I5Q59_RS29865	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I5Q59_RS29870	COG2815	serine threonine protein kinase
I5Q59_RS29870	COG0515	serine threonine protein kinase
I5Q59_RS29875	COG4771	TonB-dependent receptor
I5Q59_RS29890	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
I5Q59_RS29895	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I5Q59_RS29910	COG0326	Molecular chaperone. Has ATPase activity
I5Q59_RS29920	COG2205	protein histidine kinase activity
I5Q59_RS29925	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I5Q59_RS29950	COG1233	COG1233 Phytoene dehydrogenase and related
I5Q59_RS29955	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
I5Q59_RS29960	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I5Q59_RS29965	COG0134	indole-3-glycerol-phosphate synthase activity
I5Q59_RS29970	COG0135	phosphoribosylanthranilate isomerase activity
I5Q59_RS29975	COG0133	tryptophan synthase activity
I5Q59_RS29980	COG0159	tryptophan synthase activity
I5Q59_RS30020	COG1793	dna ligase
I5Q59_RS30020	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
I5Q59_RS30025	COG1201	RNA secondary structure unwinding
I5Q59_RS30045	COG0437	4 iron, 4 sulfur cluster binding
I5Q59_RS30080	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I5Q59_RS30125	COG0429	hydrolase of the alpha beta-hydrolase fold
I5Q59_RS30165	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I5Q59_RS30190	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
I5Q59_RS30205	COG0546	phosphoglycolate phosphatase activity
I5Q59_RS30230	COG2205	protein histidine kinase activity
I5Q59_RS30260	COG0322	excinuclease ABC activity
I5Q59_RS30290	COG1741	Belongs to the pirin family
I5Q59_RS30375	COG2197	response regulator
I5Q59_RS30395	COG0544	peptidyl-prolyl cis-trans isomerase activity
I5Q59_RS30405	COG2824	Alkylphosphonate utilization operon protein PhnA
I5Q59_RS30410	COG0785	Cytochrome C biogenesis protein
I5Q59_RS30415	COG0583	DNA-binding transcription factor activity
I5Q59_RS30425	COG1028	Short-chain dehydrogenase reductase Sdr
I5Q59_RS30440	COG2188	Transcriptional regulator
I5Q59_RS30455	COG0500	methyltransferase
I5Q59_RS30470	COG0583	DNA-binding transcription factor activity
I5Q59_RS30475	COG3387	PFAM Glycoside hydrolase 15-related
I5Q59_RS30480	COG1063	alcohol dehydrogenase
I5Q59_RS30485	COG0667	Aldo Keto reductase
I5Q59_RS30520	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I5Q59_RS30535	COG0004	ammonium transporteR
I5Q59_RS30545	COG0515	serine threonine protein kinase
I5Q59_RS30560	COG1760	l-serine dehydratase
I5Q59_RS30570	COG0693	protein deglycase activity
I5Q59_RS30570	COG0753	catalase activity
I5Q59_RS30595	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
I5Q59_RS30605	COG0438	transferase activity, transferring glycosyl groups
I5Q59_RS30615	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I5Q59_RS30620	COG3938	Belongs to the proline racemase family
I5Q59_RS30625	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I5Q59_RS30640	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I5Q59_RS30650	COG3291	Pkd domain containing protein
I5Q59_RS30680	COG0300	oxidoreductase activity
I5Q59_RS30720	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I5Q59_RS30725	COG4221	oxidoreductase activity
I5Q59_RS30735	COG5002	protein histidine kinase activity
I5Q59_RS30740	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
I5Q59_RS30780	COG2814	Major facilitator Superfamily
I5Q59_RS30815	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
I5Q59_RS30840	COG2885	chlorophyll binding
I5Q59_RS30850	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I5Q59_RS30855	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I5Q59_RS30865	COG1309	transcriptional regulator
I5Q59_RS30925	COG1509	lysine 2,3-aminomutase activity
I5Q59_RS30980	COG0640	Transcriptional regulator
I5Q59_RS31015	COG2342	PFAM TM1410 hypothetical-related protein
I5Q59_RS31030	COG4584	PFAM Integrase catalytic
I5Q59_RS31035	COG1484	DNA-dependent DNA replication
I5Q59_RS31075	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I5Q59_RS31080	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
I5Q59_RS31085	COG0469	pyruvate kinase activity
I5Q59_RS31115	COG0517	IMP dehydrogenase activity
I5Q59_RS31115	COG1994	Peptidase M50
I5Q59_RS31140	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I5Q59_RS31150	COG0515	serine threonine protein kinase
I5Q59_RS31160	COG3394	polysaccharide catabolic process
I5Q59_RS31165	COG2205	protein histidine kinase activity
I5Q59_RS31170	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I5Q59_RS31175	COG2815	serine threonine protein kinase
I5Q59_RS31175	COG0515	serine threonine protein kinase
I5Q59_RS31185	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I5Q59_RS31200	COG0248	Ppx GppA phosphatase
I5Q59_RS31210	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I5Q59_RS31215	COG1028	Short-chain dehydrogenase reductase Sdr
I5Q59_RS31270	COG0473	3-isopropylmalate dehydrogenase activity
I5Q59_RS31275	COG0023	Translation Initiation Factor
I5Q59_RS31280	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I5Q59_RS31290	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I5Q59_RS31300	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
I5Q59_RS31320	COG0625	glutathione transferase activity
I5Q59_RS31355	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I5Q59_RS31360	COG0277	FAD linked oxidase domain protein
I5Q59_RS31420	COG1309	transcriptional regulator
I5Q59_RS31425	COG0741	lytic transglycosylase activity
I5Q59_RS31430	COG0363	glucosamine-6-phosphate deaminase activity
I5Q59_RS31445	COG0318	PFAM AMP-dependent synthetase and ligase
I5Q59_RS31485	COG1408	metallophosphoesterase
I5Q59_RS31490	COG0235	Class ii aldolase
I5Q59_RS31495	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
I5Q59_RS31500	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
I5Q59_RS31525	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I5Q59_RS31530	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I5Q59_RS31535	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I5Q59_RS31540	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I5Q59_RS31545	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I5Q59_RS31555	COG1028	Short-chain dehydrogenase reductase Sdr
I5Q59_RS31560	COG1028	Short-chain dehydrogenase reductase Sdr
I5Q59_RS31565	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I5Q59_RS31570	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I5Q59_RS31575	COG1136	(ABC) transporter
I5Q59_RS31575	COG0577	efflux transmembrane transporter activity
I5Q59_RS31630	COG0745	RESPONSE REGULATOR receiver
I5Q59_RS31650	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
I5Q59_RS31690	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I5Q59_RS31695	COG2204	response regulator
I5Q59_RS31705	COG2815	serine threonine protein kinase
I5Q59_RS31705	COG0515	serine threonine protein kinase
I5Q59_RS31720	COG1960	acyl-CoA dehydrogenase activity
I5Q59_RS31735	COG4783	chaperone-mediated protein folding
I5Q59_RS31750	COG0740	serine-type endopeptidase activity
I5Q59_RS31755	COG0114	fumarate hydratase activity
I5Q59_RS31765	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I5Q59_RS31770	COG2224	Isocitrate lyase
I5Q59_RS31845	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I5Q59_RS31860	COG2094	Belongs to the DNA glycosylase MPG family
I5Q59_RS31865	COG1640	4-alpha-glucanotransferase
I5Q59_RS31890	COG0583	DNA-binding transcription factor activity
I5Q59_RS31930	COG1131	(ABC) transporter
I5Q59_RS31940	COG0714	Associated with various cellular activities
I5Q59_RS31965	COG0667	Aldo Keto reductase
I5Q59_RS32040	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I5Q59_RS32045	COG1940	carbohydrate kinase activity
I5Q59_RS32095	COG3119	arylsulfatase activity
I5Q59_RS32110	COG3795	YCII-related domain
I5Q59_RS32130	COG1968	undecaprenyl-diphosphatase activity
I5Q59_RS32135	COG3012	SEC-C Motif Domain Protein
I5Q59_RS32140	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I5Q59_RS32145	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I5Q59_RS32170	COG1285	pathogenesis
I5Q59_RS32175	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I5Q59_RS32180	COG0523	cobalamin synthesis protein
I5Q59_RS32190	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I5Q59_RS32200	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I5Q59_RS32210	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I5Q59_RS32220	COG3716	PTS system mannose fructose sorbose family IID component
I5Q59_RS32230	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I5Q59_RS32235	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5Q59_RS32235	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I5Q59_RS32240	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I5Q59_RS32285	COG4771	TonB-dependent receptor
I5Q59_RS32310	COG0601	transmembrane transport
I5Q59_RS32315	COG0444	Belongs to the ABC transporter superfamily
I5Q59_RS32320	COG4608	Belongs to the ABC transporter superfamily
I5Q59_RS32355	COG0515	serine threonine protein kinase
I5Q59_RS32370	COG1660	Displays ATPase and GTPase activities
I5Q59_RS32375	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
I5Q59_RS32380	COG0537	adenosine 5'-monophosphoramidase activity
I5Q59_RS32395	COG1120	ATPase activity
I5Q59_RS32410	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I5Q59_RS32410	COG0723	plastoquinol--plastocyanin reductase activity
I5Q59_RS32425	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5Q59_RS32440	COG4206	TonB-dependent receptor
I5Q59_RS32470	COG2205	protein histidine kinase activity
I5Q59_RS32470	COG3437	response regulator, receiver
I5Q59_RS32470	COG3850	Histidine kinase
I5Q59_RS32470	COG4999	Histidine kinase
I5Q59_RS32525	COG0823	Involved in the tonB-independent uptake of proteins
I5Q59_RS32525	COG1506	peptidase
I5Q59_RS32530	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I5Q59_RS32540	COG0443	Heat shock 70 kDa protein
I5Q59_RS32550	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I5Q59_RS32555	COG1024	Enoyl-CoA hydratase
I5Q59_RS32565	COG0714	Associated with various cellular activities
I5Q59_RS32605	COG0513	Belongs to the DEAD box helicase family
I5Q59_RS32615	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
I5Q59_RS32620	COG0745	RESPONSE REGULATOR receiver
I5Q59_RS32625	COG1472	Belongs to the glycosyl hydrolase 3 family
I5Q59_RS32635	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I5Q59_RS32650	COG0745	RESPONSE REGULATOR receiver
I5Q59_RS32665	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I5Q59_RS32665	COG0546	phosphoglycolate phosphatase activity
I5Q59_RS32670	COG0277	FAD linked oxidase domain protein
I5Q59_RS32695	COG0318	PFAM AMP-dependent synthetase and ligase
I5Q59_RS32700	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I5Q59_RS32705	COG1755	Isoprenylcysteine carboxyl methyltransferase
I5Q59_RS32725	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
I5Q59_RS32730	COG4149	molybdate abc transporter
I5Q59_RS32735	COG0725	ABC transporter, periplasmic molybdate-binding protein
I5Q59_RS32740	COG1846	Transcriptional regulator
I5Q59_RS32745	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I5Q59_RS32750	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I5Q59_RS32790	COG0442	prolyl-tRNA aminoacylation
I5Q59_RS32795	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
I5Q59_RS32810	COG4106	trans-aconitate 2-methyltransferase activity
I5Q59_RS32845	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
I5Q59_RS32870	COG0443	Heat shock 70 kDa protein
I5Q59_RS32875	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I5Q59_RS32950	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
I5Q59_RS32955	COG1691	(AIR) carboxylase
I5Q59_RS32965	COG0643	Histidine kinase
I5Q59_RS32965	COG2198	Histidine kinase
I5Q59_RS32970	COG2201	protein-glutamate methylesterase activity
I5Q59_RS32975	COG0835	chemotaxis
I5Q59_RS32990	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I5Q59_RS33015	COG2205	protein histidine kinase activity
I5Q59_RS33015	COG0784	Response regulator, receiver
I5Q59_RS33015	COG5002	protein histidine kinase activity
I5Q59_RS33020	COG1100	Small GTP-binding protein
I5Q59_RS33025	COG0456	acetyltransferase
I5Q59_RS33045	COG2137	regulation of response to DNA damage stimulus
I5Q59_RS33075	COG0024	Methionine aminopeptidase
I5Q59_RS33085	COG4206	TonB-dependent receptor
I5Q59_RS33090	COG1199	ATP-dependent helicase activity
I5Q59_RS33115	COG0546	phosphoglycolate phosphatase activity
I5Q59_RS33125	COG1597	lipid kinase activity
I5Q59_RS33135	COG1420	regulation of RNA biosynthetic process
I5Q59_RS33140	COG0697	spore germination
I5Q59_RS33155	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I5Q59_RS33160	COG0235	Class ii aldolase
I5Q59_RS33175	COG0784	Response regulator, receiver
I5Q59_RS33175	COG5002	protein histidine kinase activity
I5Q59_RS33175	COG2205	protein histidine kinase activity
I5Q59_RS33230	COG2133	pyrroloquinoline quinone binding
I5Q59_RS33235	COG1028	Short-chain dehydrogenase reductase Sdr
I5Q59_RS33310	COG0408	coproporphyrinogen oxidase activity
I5Q59_RS33325	COG2267	carboxylic ester hydrolase activity
I5Q59_RS33335	COG0577	efflux transmembrane transporter activity
I5Q59_RS33360	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I5Q59_RS33370	COG2154	pterin-4-alpha-carbinolamine dehydratase
I5Q59_RS33390	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I5Q59_RS33400	COG2171	N-acyltransferase activity
I5Q59_RS33420	COG0076	glutamate decarboxylase activity
I5Q59_RS33430	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I5Q59_RS33430	COG4651	solute:proton antiporter activity
I5Q59_RS33450	COG1077	Cell shape determining protein MreB Mrl
I5Q59_RS33465	COG0583	DNA-binding transcription factor activity
I5Q59_RS33470	COG2155	Conserved Protein
I5Q59_RS33480	COG3781	membrane
I5Q59_RS33505	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I5Q59_RS33505	COG0574	Belongs to the PEP-utilizing enzyme family
I5Q59_RS33510	COG1063	alcohol dehydrogenase
I5Q59_RS33520	COG0534	Mate efflux family protein
I5Q59_RS33525	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I5Q59_RS33555	COG1505	serine-type exopeptidase activity
I5Q59_RS33570	COG3594	Acyltransferase
I5Q59_RS33610	COG0308	aminopeptidase N
I5Q59_RS33630	COG1668	transmembrane transport
I5Q59_RS33635	COG4555	ABC transporter
I5Q59_RS33650	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
I5Q59_RS33675	COG3568	Endonuclease Exonuclease Phosphatase
I5Q59_RS33675	COG1555	photosystem II stabilization
I5Q59_RS33705	COG0477	Major facilitator Superfamily
I5Q59_RS33735	COG5002	protein histidine kinase activity
I5Q59_RS33740	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I5Q59_RS33755	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I5Q59_RS33755	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I5Q59_RS33795	COG0546	phosphoglycolate phosphatase activity
I5Q59_RS33815	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I5Q59_RS33820	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I5Q59_RS33820	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I5Q59_RS33840	COG0720	synthase
I5Q59_RS33845	COG4221	oxidoreductase activity
I5Q59_RS33885	COG1028	Short-chain dehydrogenase reductase Sdr
I5Q59_RS33900	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I5Q59_RS33950	COG1160	GTP binding
I5Q59_RS33965	COG2885	chlorophyll binding
I5Q59_RS33965	COG3047	cAMP biosynthetic process
I5Q59_RS34015	COG0166	Belongs to the GPI family
I5Q59_RS34020	COG1028	Short-chain dehydrogenase reductase Sdr
I5Q59_RS34030	COG4771	TonB-dependent receptor
I5Q59_RS34040	COG1271	oxidase subunit
I5Q59_RS34065	COG1959	2 iron, 2 sulfur cluster binding
I5Q59_RS34075	COG2346	COG2346, Truncated hemoglobins
I5Q59_RS34080	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I5Q59_RS34090	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I5Q59_RS34100	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I5Q59_RS34105	COG0784	Response regulator, receiver
I5Q59_RS34105	COG0835	chemotaxis
I5Q59_RS34110	COG2949	membrane
I5Q59_RS34125	COG3118	belongs to the thioredoxin family
I5Q59_RS34180	COG2205	protein histidine kinase activity
I5Q59_RS34180	COG5002	protein histidine kinase activity
I5Q59_RS34180	COG0784	Response regulator, receiver
I5Q59_RS34200	COG0835	chemotaxis
I5Q59_RS34215	COG0840	transmembrane signaling receptor activity
I5Q59_RS34225	COG2201	protein-glutamate methylesterase activity
I5Q59_RS34230	COG5002	protein histidine kinase activity
I5Q59_RS34240	COG5002	protein histidine kinase activity
I5Q59_RS34245	COG0745	RESPONSE REGULATOR receiver
I5Q59_RS34260	COG2201	protein-glutamate methylesterase activity
I5Q59_RS34280	COG0835	chemotaxis
I5Q59_RS34285	COG0643	Histidine kinase
I5Q59_RS34285	COG2198	Histidine kinase
I5Q59_RS34295	COG5002	protein histidine kinase activity
I5Q59_RS34305	COG0745	RESPONSE REGULATOR receiver
I5Q59_RS34320	COG2205	protein histidine kinase activity
I5Q59_RS34320	COG5002	protein histidine kinase activity
I5Q59_RS34320	COG0784	Response regulator, receiver
I5Q59_RS34325	COG1408	metallophosphoesterase
I5Q59_RS34360	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
I5Q59_RS34370	COG2226	methyltransferase
I5Q59_RS34375	COG0789	Transcriptional regulator
I5Q59_RS34390	COG1012	belongs to the aldehyde dehydrogenase family
I5Q59_RS34400	COG0183	Belongs to the thiolase family
I5Q59_RS34430	COG5002	protein histidine kinase activity
I5Q59_RS34465	COG0745	RESPONSE REGULATOR receiver
I5Q59_RS34475	COG5002	protein histidine kinase activity
I5Q59_RS34545	COG1518	maintenance of DNA repeat elements
I5Q59_RS34570	COG1203	CRISPR-associated helicase, Cas3
I5Q59_RS34580	COG0534	Mate efflux family protein
I5Q59_RS34595	COG0443	Heat shock 70 kDa protein
I5Q59_RS34600	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I5Q59_RS34635	COG2204	response regulator
I5Q59_RS34645	COG0746	molybdenum cofactor guanylyltransferase activity
I5Q59_RS34660	COG2267	carboxylic ester hydrolase activity
I5Q59_RS34670	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I5Q59_RS34670	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I5Q59_RS34680	COG0667	Aldo Keto reductase
I5Q59_RS34745	COG2270	Major facilitator Superfamily
I5Q59_RS34760	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I5Q59_RS34770	COG0217	transcriptional regulatory protein
I5Q59_RS34795	COG1733	regulation of RNA biosynthetic process
I5Q59_RS34825	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I5Q59_RS34875	COG0515	serine threonine protein kinase
I5Q59_RS34875	COG2815	serine threonine protein kinase
I5Q59_RS34915	COG0386	Belongs to the glutathione peroxidase family
I5Q59_RS34935	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
I5Q59_RS35010	COG0412	Dienelactone hydrolase
I5Q59_RS35015	COG0545	Peptidyl-prolyl cis-trans isomerase
I5Q59_RS35040	COG4149	molybdate abc transporter
I5Q59_RS35060	COG0534	Mate efflux family protein
I5Q59_RS35080	COG2205	protein histidine kinase activity
I5Q59_RS35160	COG1058	Belongs to the CinA family
I5Q59_RS35160	COG1546	Belongs to the CinA family
I5Q59_RS35165	COG0768	penicillin binding
I5Q59_RS35180	COG3852	Histidine kinase
I5Q59_RS35190	COG0577	efflux transmembrane transporter activity
I5Q59_RS35190	COG1136	(ABC) transporter
I5Q59_RS35195	COG1136	(ABC) transporter
I5Q59_RS35200	COG0577	efflux transmembrane transporter activity
I5Q59_RS35200	COG1136	(ABC) transporter
I5Q59_RS35210	COG0318	PFAM AMP-dependent synthetase and ligase
I5Q59_RS35215	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
I5Q59_RS35225	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I5Q59_RS35245	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I5Q59_RS35250	COG1024	Enoyl-CoA hydratase
I5Q59_RS35255	COG0308	aminopeptidase N
I5Q59_RS35260	COG1560	Kdo2-lipid A biosynthetic process
I5Q59_RS35275	COG2815	serine threonine protein kinase
I5Q59_RS35275	COG0515	serine threonine protein kinase
I5Q59_RS35280	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I5Q59_RS35290	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I5Q59_RS35340	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I5Q59_RS35350	COG0745	RESPONSE REGULATOR receiver
I5Q59_RS35360	COG2205	protein histidine kinase activity
I5Q59_RS35390	COG0438	transferase activity, transferring glycosyl groups
I5Q59_RS35395	COG0438	transferase activity, transferring glycosyl groups
I5Q59_RS35420	COG1056	cytidyltransferase-related domain
I5Q59_RS35420	COG1051	belongs to the nudix hydrolase family
I5Q59_RS35430	COG1028	Short-chain dehydrogenase reductase Sdr
I5Q59_RS35495	COG0515	serine threonine protein kinase
I5Q59_RS35575	COG3842	ATPase activity
I5Q59_RS35580	COG1127	ABC transporter
I5Q59_RS35605	COG0596	Alpha beta hydrolase
I5Q59_RS35645	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I5Q59_RS35680	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I5Q59_RS35690	COG0515	serine threonine protein kinase
I5Q59_RS35695	COG3932	Exopolysaccharide synthesis, ExoD
I5Q59_RS35705	COG0702	epimerase
I5Q59_RS35730	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
I5Q59_RS35735	COG1468	defense response to virus
I5Q59_RS35735	COG1518	maintenance of DNA repeat elements
I5Q59_RS35745	COG1857	crispr-associated protein
I5Q59_RS35755	COG1203	CRISPR-associated helicase, Cas3
I5Q59_RS35775	COG0515	serine threonine protein kinase
I5Q59_RS35795	COG4279	zinc finger
I5Q59_RS35800	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I5Q59_RS35850	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I5Q59_RS35905	COG1653	transport
I5Q59_RS35935	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I5Q59_RS35950	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I5Q59_RS35950	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I5Q59_RS35975	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
I5Q59_RS35990	COG1960	acyl-CoA dehydrogenase activity
I5Q59_RS35995	COG0583	DNA-binding transcription factor activity
I5Q59_RS36015	COG1309	transcriptional regulator
I5Q59_RS36035	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I5Q59_RS36050	COG1064	alcohol dehydrogenase
I5Q59_RS36060	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I5Q59_RS36060	COG2755	lipolytic protein G-D-S-L family
I5Q59_RS36080	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I5Q59_RS36165	COG0242	peptide deformylase activity
I5Q59_RS36195	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I5Q59_RS36215	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I5Q59_RS36230	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I5Q59_RS36250	COG5002	protein histidine kinase activity
I5Q59_RS36255	COG0745	RESPONSE REGULATOR receiver
I5Q59_RS36270	COG5001	Diguanylate cyclase
I5Q59_RS36285	COG0515	serine threonine protein kinase
I5Q59_RS36285	COG2815	serine threonine protein kinase
I5Q59_RS36310	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I5Q59_RS36320	COG0003	Pfam Anion-transporting ATPase
I5Q59_RS36360	COG1388	LysM domain
I5Q59_RS36360	COG3942	CHAP domain
I5Q59_RS36385	COG3290	protein histidine kinase activity
I5Q59_RS36385	COG3829	transcription factor binding
I5Q59_RS36410	COG5002	protein histidine kinase activity
I5Q59_RS36420	COG3483	tryptophan 2,3-dioxygenase activity
I5Q59_RS36440	COG0506	proline dehydrogenase activity
I5Q59_RS36445	COG3387	PFAM Glycoside hydrolase 15-related
I5Q59_RS36460	COG2814	Major facilitator Superfamily
I5Q59_RS36475	COG0746	molybdenum cofactor guanylyltransferase activity
I5Q59_RS36490	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I5Q59_RS36515	COG0745	RESPONSE REGULATOR receiver
I5Q59_RS36555	COG2304	oxidoreductase activity
I5Q59_RS36600	COG2239	Acts as a magnesium transporter
I5Q59_RS36605	COG5002	protein histidine kinase activity
I5Q59_RS36625	COG1045	serine acetyltransferase
I5Q59_RS36695	COG0038	chloride channel
I5Q59_RS36720	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I5Q59_RS36725	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
I5Q59_RS36745	COG1475	DNA binding
I5Q59_RS36750	COG1192	Involved in chromosome partitioning
I5Q59_RS36765	COG0357	Ribosomal RNA small subunit methyltransferase G
I5Q59_RS36770	COG0445	tRNA wobble uridine modification
I5Q59_RS36775	COG2814	Major facilitator Superfamily
I5Q59_RS36780	COG2267	carboxylic ester hydrolase activity
I5Q59_RS36790	COG0612	Peptidase, M16
I5Q59_RS36795	COG0616	signal peptide processing
I5Q59_RS36810	COG0640	Transcriptional regulator
I5Q59_RS36815	COG3832	glyoxalase III activity
I5Q59_RS36830	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I5Q59_RS36845	COG0706	membrane insertase activity
I5Q59_RS36850	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I5Q59_RS36855	COG0594	ribonuclease P activity
I5Q59_RS36860	COG0230	Belongs to the bacterial ribosomal protein bL34 family