locus-tag	class	description
BHS04_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BHS04_RS00050	COG2814	Major facilitator Superfamily
BHS04_RS00060	COG2259	Doxx family
BHS04_RS00070	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
BHS04_RS00075	COG3550	peptidyl-serine autophosphorylation
BHS04_RS00085	COG0189	ligase activity
BHS04_RS00090	COG0515	serine threonine protein kinase
BHS04_RS00125	COG0515	serine threonine protein kinase
BHS04_RS00130	COG0557	exoribonuclease II activity
BHS04_RS00210	COG1063	alcohol dehydrogenase
BHS04_RS00215	COG3387	PFAM Glycoside hydrolase 15-related
BHS04_RS00235	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
BHS04_RS00275	COG1690	Belongs to the RtcB family
BHS04_RS00305	COG2815	serine threonine protein kinase
BHS04_RS00305	COG0515	serine threonine protein kinase
BHS04_RS00330	COG0402	S-adenosylhomocysteine deaminase activity
BHS04_RS00335	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BHS04_RS00335	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
BHS04_RS00350	COG1028	Short-chain dehydrogenase reductase Sdr
BHS04_RS00365	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BHS04_RS00375	COG2814	Major facilitator Superfamily
BHS04_RS00380	COG3491	Belongs to the iron ascorbate-dependent oxidoreductase family
BHS04_RS00405	COG0625	glutathione transferase activity
BHS04_RS00440	COG2226	methyltransferase
BHS04_RS00445	COG3550	peptidyl-serine autophosphorylation
BHS04_RS00470	COG0477	Major facilitator Superfamily
BHS04_RS00480	COG1136	(ABC) transporter
BHS04_RS00480	COG0577	efflux transmembrane transporter activity
BHS04_RS00485	COG0577	efflux transmembrane transporter activity
BHS04_RS00525	COG2204	response regulator
BHS04_RS00530	COG0515	serine threonine protein kinase
BHS04_RS00555	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
BHS04_RS00555	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BHS04_RS00565	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BHS04_RS00600	COG0038	chloride channel
BHS04_RS00620	COG0815	Transfers the fatty acyl group on membrane lipoproteins
BHS04_RS00630	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
BHS04_RS00635	COG1073	alpha beta
BHS04_RS00685	COG4717	serine-type aminopeptidase activity
BHS04_RS00690	COG0420	3'-5' exonuclease activity
BHS04_RS00710	COG5000	phosphorelay sensor kinase activity
BHS04_RS00720	COG5006	permease, DMT superfamily
BHS04_RS00750	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BHS04_RS00780	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
BHS04_RS00785	COG2205	protein histidine kinase activity
BHS04_RS00790	COG5002	protein histidine kinase activity
BHS04_RS00810	COG0840	transmembrane signaling receptor activity
BHS04_RS00815	COG2759	Belongs to the formate--tetrahydrofolate ligase family
BHS04_RS00825	COG2205	protein histidine kinase activity
BHS04_RS00835	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BHS04_RS00840	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BHS04_RS00845	COG2204	response regulator
BHS04_RS00850	COG0446	pyridine nucleotide-disulphide oxidoreductase
BHS04_RS00915	COG2304	oxidoreductase activity
BHS04_RS00930	COG5002	protein histidine kinase activity
BHS04_RS00940	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BHS04_RS00945	COG0697	spore germination
BHS04_RS00965	COG2226	methyltransferase
BHS04_RS00970	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BHS04_RS00975	COG1404	Belongs to the peptidase S8 family
BHS04_RS00985	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BHS04_RS00995	COG1196	nuclear chromosome segregation
BHS04_RS00995	COG0741	lytic transglycosylase activity
BHS04_RS00995	COG0739	heme binding
BHS04_RS01000	COG1028	Short-chain dehydrogenase reductase Sdr
BHS04_RS01005	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BHS04_RS01010	COG1522	sequence-specific DNA binding
BHS04_RS01050	COG1309	transcriptional regulator
BHS04_RS01055	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BHS04_RS01060	COG0318	PFAM AMP-dependent synthetase and ligase
BHS04_RS01120	COG0840	transmembrane signaling receptor activity
BHS04_RS01130	COG5002	protein histidine kinase activity
BHS04_RS01195	COG4335	DNA alkylation repair
BHS04_RS01205	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BHS04_RS01220	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BHS04_RS01225	COG1127	ABC transporter
BHS04_RS01260	COG5002	protein histidine kinase activity
BHS04_RS01280	COG0745	RESPONSE REGULATOR receiver
BHS04_RS01285	COG0475	glutathione-regulated potassium exporter activity
BHS04_RS01290	COG1396	sequence-specific DNA binding
BHS04_RS01370	COG1051	belongs to the nudix hydrolase family
BHS04_RS01375	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BHS04_RS01380	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BHS04_RS01385	COG1690	Belongs to the RtcB family
BHS04_RS01410	COG2181	nitrate reductase activity
BHS04_RS01410	COG0247	lactate metabolic process
BHS04_RS01440	COG0477	Major facilitator Superfamily
BHS04_RS01455	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BHS04_RS01460	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BHS04_RS01490	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BHS04_RS01495	COG0667	Aldo Keto reductase
BHS04_RS01530	COG2197	response regulator
BHS04_RS01540	COG4948	Mandelate Racemase Muconate Lactonizing
BHS04_RS01595	COG0586	Pfam SNARE associated Golgi protein
BHS04_RS01630	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BHS04_RS01650	COG0745	RESPONSE REGULATOR receiver
BHS04_RS01670	COG5002	protein histidine kinase activity
BHS04_RS01675	COG3158	transport of potassium into the cell
BHS04_RS01700	COG0823	Involved in the tonB-independent uptake of proteins
BHS04_RS01730	COG0189	ligase activity
BHS04_RS01765	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BHS04_RS01775	COG4966	pilus assembly protein PilW
BHS04_RS01815	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BHS04_RS01820	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BHS04_RS01825	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BHS04_RS01870	COG2239	Acts as a magnesium transporter
BHS04_RS01930	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BHS04_RS01950	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BHS04_RS01955	COG0515	serine threonine protein kinase
BHS04_RS01965	COG4191	Histidine kinase
BHS04_RS01970	COG1881	PFAM PEBP family protein
BHS04_RS01985	COG0356	it plays a direct role in the translocation of protons across the membrane
BHS04_RS01990	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BHS04_RS01995	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BHS04_RS02000	COG0012	GTP binding
BHS04_RS02010	COG0372	Belongs to the citrate synthase family
BHS04_RS02015	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BHS04_RS02050	COG1408	metallophosphoesterase
BHS04_RS02080	COG0583	DNA-binding transcription factor activity
BHS04_RS02105	COG1960	acyl-CoA dehydrogenase activity
BHS04_RS02245	COG0667	Aldo Keto reductase
BHS04_RS02270	COG4191	Histidine kinase
BHS04_RS02275	COG2204	response regulator
BHS04_RS02280	COG3852	Histidine kinase
BHS04_RS02290	COG0006	proline dipeptidase activity
BHS04_RS02315	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
BHS04_RS02320	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BHS04_RS02325	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BHS04_RS02340	COG2827	Endonuclease containing a URI domain
BHS04_RS02365	COG0602	queuosine metabolic process
BHS04_RS02370	COG2816	NAD+ diphosphatase activity
BHS04_RS02375	COG0346	lactoylglutathione lyase activity
BHS04_RS02390	COG2070	2-Nitropropane dioxygenase
BHS04_RS02460	COG3436	PFAM IS66 Orf2 family protein
BHS04_RS02590	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BHS04_RS02670	COG4771	TonB-dependent receptor
BHS04_RS02680	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
BHS04_RS02680	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
BHS04_RS02705	COG2815	serine threonine protein kinase
BHS04_RS02705	COG0515	serine threonine protein kinase
BHS04_RS02735	COG0436	Aminotransferase
BHS04_RS02755	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BHS04_RS02755	COG0551	DNA topoisomerase type I activity
BHS04_RS02765	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BHS04_RS02780	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BHS04_RS02785	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BHS04_RS02820	COG0625	glutathione transferase activity
BHS04_RS02840	COG0515	serine threonine protein kinase
BHS04_RS02845	COG0842	Transport permease protein
BHS04_RS02850	COG1131	(ABC) transporter
BHS04_RS02880	COG0488	(ABC) transporter
BHS04_RS02890	COG1876	peptidase activity
BHS04_RS02895	COG0501	Belongs to the peptidase M48B family
BHS04_RS02945	COG5002	protein histidine kinase activity
BHS04_RS02970	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BHS04_RS03000	COG2373	Large extracellular alpha-helical protein
BHS04_RS03035	COG1819	glycosyl
BHS04_RS03050	COG1125	glycine betaine transport
BHS04_RS03070	COG0109	protoheme IX farnesyltransferase activity
BHS04_RS03070	COG1612	heme a metabolic process
BHS04_RS03075	COG2204	response regulator
BHS04_RS03090	COG0668	transmembrane transport
BHS04_RS03105	COG0671	phosphoesterase, PA-phosphatase related
BHS04_RS03115	COG0110	maltose O-acetyltransferase activity
BHS04_RS03120	COG4191	Histidine kinase
BHS04_RS03135	COG1793	dna ligase
BHS04_RS03140	COG3265	gluconokinase activity
BHS04_RS03150	COG2376	Dihydroxyacetone kinase
BHS04_RS03155	COG1028	Short-chain dehydrogenase reductase Sdr
BHS04_RS03180	COG0488	(ABC) transporter
BHS04_RS03210	COG1309	transcriptional regulator
BHS04_RS03220	COG4191	Histidine kinase
BHS04_RS03265	COG1192	Involved in chromosome partitioning
BHS04_RS03275	COG0501	Belongs to the peptidase M48B family
BHS04_RS03285	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
BHS04_RS03310	COG5002	protein histidine kinase activity
BHS04_RS03315	COG0308	aminopeptidase N
BHS04_RS03355	COG1846	Transcriptional regulator
BHS04_RS03360	COG1764	response to oxidative stress
BHS04_RS03380	COG1574	metal-dependent hydrolase with the TIM-barrel fold
BHS04_RS03400	COG1234	tRNA 3'-trailer cleavage
BHS04_RS03410	COG1309	transcriptional regulator
BHS04_RS03415	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BHS04_RS03445	COG1278	Cold shock
BHS04_RS03475	COG0667	Aldo Keto reductase
BHS04_RS03490	COG1131	(ABC) transporter
BHS04_RS03495	COG3795	YCII-related domain
BHS04_RS03500	COG4941	Belongs to the sigma-70 factor family
BHS04_RS03505	COG1028	Short-chain dehydrogenase reductase Sdr
BHS04_RS03520	COG0583	DNA-binding transcription factor activity
BHS04_RS03530	COG2124	cytochrome p450
BHS04_RS03535	COG4604	ABC transporter, ATP-binding protein
BHS04_RS03540	COG4605	iron ion homeostasis
BHS04_RS03545	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BHS04_RS03550	COG4607	ABC-type enterochelin transport system periplasmic component
BHS04_RS03600	COG1136	(ABC) transporter
BHS04_RS03600	COG0577	efflux transmembrane transporter activity
BHS04_RS03650	COG2031	fatty acid transporter
BHS04_RS03660	COG5002	protein histidine kinase activity
BHS04_RS03675	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
BHS04_RS03680	COG0745	RESPONSE REGULATOR receiver
BHS04_RS03690	COG3850	Histidine kinase
BHS04_RS03690	COG3437	response regulator, receiver
BHS04_RS03690	COG2205	protein histidine kinase activity
BHS04_RS03690	COG4999	Histidine kinase
BHS04_RS03695	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BHS04_RS03700	COG2201	protein-glutamate methylesterase activity
BHS04_RS03705	COG3437	response regulator, receiver
BHS04_RS03750	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BHS04_RS03755	COG0745	RESPONSE REGULATOR receiver
BHS04_RS03775	COG3483	tryptophan 2,3-dioxygenase activity
BHS04_RS03780	COG0745	RESPONSE REGULATOR receiver
BHS04_RS03785	COG3850	Histidine kinase
BHS04_RS03785	COG3437	response regulator, receiver
BHS04_RS03785	COG4999	Histidine kinase
BHS04_RS03785	COG2205	protein histidine kinase activity
BHS04_RS03800	COG5002	protein histidine kinase activity
BHS04_RS03805	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BHS04_RS03855	COG1132	(ABC) transporter
BHS04_RS03865	COG0484	heat shock protein binding
BHS04_RS03910	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BHS04_RS03970	COG0745	RESPONSE REGULATOR receiver
BHS04_RS04000	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BHS04_RS04020	COG3842	ATPase activity
BHS04_RS04030	COG0300	oxidoreductase activity
BHS04_RS04055	COG0330	HflC and HflK could
BHS04_RS04065	COG0438	transferase activity, transferring glycosyl groups
BHS04_RS04075	COG1574	metal-dependent hydrolase with the TIM-barrel fold
BHS04_RS04080	COG0583	DNA-binding transcription factor activity
BHS04_RS04100	COG0602	queuosine metabolic process
BHS04_RS04145	COG0612	Peptidase, M16
BHS04_RS04175	COG1960	acyl-CoA dehydrogenase activity
BHS04_RS04225	COG4251	negative regulation of phosphorylation
BHS04_RS04230	COG0784	Response regulator, receiver
BHS04_RS04270	COG0679	Auxin Efflux Carrier
BHS04_RS04325	COG1028	Short-chain dehydrogenase reductase Sdr
BHS04_RS04390	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
BHS04_RS04400	COG0804	urea catabolic process
BHS04_RS04405	COG0832	Belongs to the urease beta subunit family
BHS04_RS04405	COG0831	urea catabolic process
BHS04_RS04410	COG0829	nickel cation binding
BHS04_RS04435	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BHS04_RS04450	COG0604	alcohol dehydrogenase
BHS04_RS04485	COG3383	formate dehydrogenase (NAD+) activity
BHS04_RS04495	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BHS04_RS04505	COG1360	Flagellar Motor Protein
BHS04_RS04520	COG0443	Heat shock 70 kDa protein
BHS04_RS04545	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BHS04_RS04550	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
BHS04_RS04555	COG0625	glutathione transferase activity
BHS04_RS04565	COG0783	Belongs to the Dps family
BHS04_RS04580	COG0596	Alpha beta hydrolase
BHS04_RS04635	COG0840	transmembrane signaling receptor activity
BHS04_RS04665	COG2819	hydrolase of the alpha beta superfamily
BHS04_RS04680	COG1309	transcriptional regulator
BHS04_RS04685	COG1408	metallophosphoesterase
BHS04_RS04705	COG1090	epimerase
BHS04_RS04715	COG0142	geranyltranstransferase activity
BHS04_RS04725	COG1562	ergosterol biosynthetic process
BHS04_RS04785	COG0174	glutamine synthetase
BHS04_RS04800	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BHS04_RS04805	COG3844	kynureninase activity
BHS04_RS04815	COG0662	Cupin 2, conserved barrel domain protein
BHS04_RS04865	COG4191	Histidine kinase
BHS04_RS04885	COG1297	OPT oligopeptide transporter protein
BHS04_RS04890	COG2815	serine threonine protein kinase
BHS04_RS04890	COG0515	serine threonine protein kinase
BHS04_RS04895	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BHS04_RS04910	COG2204	response regulator
BHS04_RS04940	COG1846	Transcriptional regulator
BHS04_RS04970	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BHS04_RS04980	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
BHS04_RS04985	COG0363	glucosamine-6-phosphate deaminase activity
BHS04_RS04990	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BHS04_RS05015	COG0420	3'-5' exonuclease activity
BHS04_RS05050	COG1464	Belongs to the NlpA lipoprotein family
BHS04_RS05055	COG2011	ABC-type metal ion transport system permease component
BHS04_RS05060	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BHS04_RS05065	COG0626	cystathionine gamma-synthase activity
BHS04_RS05070	COG0626	cystathionine gamma-synthase activity
BHS04_RS05075	COG0460	homoserine dehydrogenase
BHS04_RS05075	COG0527	aspartate kinase activity
BHS04_RS05100	COG1858	cytochrome C peroxidase
BHS04_RS05105	COG1858	cytochrome C peroxidase
BHS04_RS05145	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BHS04_RS05160	COG3023	N-Acetylmuramoyl-L-alanine amidase
BHS04_RS05200	COG3842	ATPase activity
BHS04_RS05205	COG0644	oxidoreductase
BHS04_RS05210	COG1201	RNA secondary structure unwinding
BHS04_RS05215	COG1404	Belongs to the peptidase S8 family
BHS04_RS05235	COG2322	membrane
BHS04_RS05305	COG5002	protein histidine kinase activity
BHS04_RS05320	COG4968	Prepilin-type N-terminal cleavage methylation domain
BHS04_RS05350	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BHS04_RS05355	COG3206	protein involved in exopolysaccharide biosynthesis
BHS04_RS05355	COG0489	protein tyrosine kinase activity
BHS04_RS05360	COG0438	transferase activity, transferring glycosyl groups
BHS04_RS05365	COG0438	transferase activity, transferring glycosyl groups
BHS04_RS05380	COG0438	transferase activity, transferring glycosyl groups
BHS04_RS05390	COG0438	transferase activity, transferring glycosyl groups
BHS04_RS05415	COG1216	Glycosyl transferase, family 2
BHS04_RS05415	COG0463	Glycosyl transferase, family 2
BHS04_RS05425	COG1940	carbohydrate kinase activity
BHS04_RS05440	COG0438	transferase activity, transferring glycosyl groups
BHS04_RS05445	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BHS04_RS05455	COG3795	YCII-related domain
BHS04_RS05500	COG3724	N-succinylarginine dihydrolase activity
BHS04_RS05505	COG1560	Kdo2-lipid A biosynthetic process
BHS04_RS05520	COG1137	ATPase activity
BHS04_RS05550	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BHS04_RS05550	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BHS04_RS05550	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BHS04_RS05560	COG1490	D-aminoacyl-tRNA deacylase activity
BHS04_RS05565	COG2027	D-alanyl-D-alanine carboxypeptidase
BHS04_RS05570	COG0629	single-stranded DNA binding
BHS04_RS05575	COG2009	succinate dehydrogenase
BHS04_RS05580	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BHS04_RS05590	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BHS04_RS05600	COG4191	Histidine kinase
BHS04_RS05605	COG2204	response regulator
BHS04_RS05615	COG1007	ATP synthesis coupled electron transport
BHS04_RS05630	COG0713	ATP synthesis coupled electron transport
BHS04_RS05635	COG0839	Belongs to the complex I subunit 6 family
BHS04_RS05660	COG0560	Phosphoserine phosphatase
BHS04_RS05660	COG3830	Belongs to the UPF0237 family
BHS04_RS05675	COG0071	Belongs to the small heat shock protein (HSP20) family
BHS04_RS05680	COG0745	RESPONSE REGULATOR receiver
BHS04_RS05685	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
BHS04_RS05690	COG2877	3-deoxy-8-phosphooctulonate synthase activity
BHS04_RS05695	COG0504	CTP synthase activity
BHS04_RS05705	COG1132	(ABC) transporter
BHS04_RS05710	COG0656	L-ascorbic acid biosynthetic process
BHS04_RS05720	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
BHS04_RS05730	COG0564	pseudouridine synthase activity
BHS04_RS05735	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
BHS04_RS05750	COG0484	heat shock protein binding
BHS04_RS05770	COG5016	pyruvate
BHS04_RS05770	COG0511	ligase activity, forming carbon-carbon bonds
BHS04_RS05775	COG0439	Biotin carboxylase
BHS04_RS05785	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BHS04_RS05800	COG3239	Fatty acid desaturase
BHS04_RS05840	COG2264	protein methyltransferase activity
BHS04_RS05850	COG2264	protein methyltransferase activity
BHS04_RS05865	COG2204	response regulator
BHS04_RS05870	COG4191	Histidine kinase
BHS04_RS05880	COG1714	RDD family
BHS04_RS05895	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BHS04_RS05925	COG2264	protein methyltransferase activity
BHS04_RS05935	COG0612	Peptidase, M16
BHS04_RS05995	COG1959	2 iron, 2 sulfur cluster binding
BHS04_RS06000	COG0719	Fe-S assembly protein
BHS04_RS06005	COG0396	ATPase activity
BHS04_RS06010	COG0719	Fe-S assembly protein
BHS04_RS06020	COG0822	iron-sulfur transferase activity
BHS04_RS06035	COG1446	asparaginase
BHS04_RS06070	COG4191	Histidine kinase
BHS04_RS06075	COG2204	response regulator
BHS04_RS06095	COG1376	ErfK ybiS ycfS ynhG family protein
BHS04_RS06100	COG0432	Pfam Uncharacterised protein family UPF0047
BHS04_RS06120	COG0544	peptidyl-prolyl cis-trans isomerase activity
BHS04_RS06130	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
BHS04_RS06180	COG5000	phosphorelay sensor kinase activity
BHS04_RS06200	COG2162	N-hydroxyarylamine O-acetyltransferase activity
BHS04_RS06225	COG1040	competence protein
BHS04_RS06235	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
BHS04_RS06245	COG1690	Belongs to the RtcB family
BHS04_RS06250	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BHS04_RS06300	COG3852	Histidine kinase
BHS04_RS06305	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BHS04_RS06315	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
BHS04_RS06325	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BHS04_RS06330	COG0156	8-amino-7-oxononanoate synthase activity
BHS04_RS06335	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
BHS04_RS06360	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
BHS04_RS06365	COG3273	potassium ion transport
BHS04_RS06365	COG0471	metal ion transport
BHS04_RS06395	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BHS04_RS06415	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BHS04_RS06435	COG3279	Response regulator of the LytR AlgR family
BHS04_RS06440	COG3275	phosphorelay sensor kinase activity
BHS04_RS06460	COG0297	glycogen (starch) synthase activity
BHS04_RS06485	COG4535	Mg2 and Co2 transporter CorC
BHS04_RS06545	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
BHS04_RS06565	COG4771	TonB-dependent receptor
BHS04_RS06575	COG3720	iron ion transport
BHS04_RS06585	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BHS04_RS06590	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
BHS04_RS06715	COG3604	Transcriptional regulator
BHS04_RS06735	COG0745	RESPONSE REGULATOR receiver
BHS04_RS06740	COG5002	protein histidine kinase activity
BHS04_RS06760	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BHS04_RS06775	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BHS04_RS06800	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BHS04_RS06805	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
BHS04_RS06810	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BHS04_RS06845	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BHS04_RS06855	COG0123	including yeast histone deacetylase and acetoin utilization protein
BHS04_RS06910	COG0405	Gamma-glutamyltransferase
BHS04_RS06920	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BHS04_RS06925	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BHS04_RS06955	COG2183	response to ionizing radiation
BHS04_RS06970	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
BHS04_RS06985	COG1413	lyase activity
BHS04_RS06995	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BHS04_RS07000	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BHS04_RS07025	COG1028	Short-chain dehydrogenase reductase Sdr
BHS04_RS07075	COG1028	Short-chain dehydrogenase reductase Sdr
BHS04_RS07100	COG0564	pseudouridine synthase activity
BHS04_RS07105	COG1215	transferase activity, transferring glycosyl groups
BHS04_RS07120	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BHS04_RS07135	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BHS04_RS07145	COG0242	peptide deformylase activity
BHS04_RS07150	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BHS04_RS07160	COG0739	heme binding
BHS04_RS07165	COG0776	regulation of translation
BHS04_RS07180	COG1183	phosphatidylcholine synthase activity
BHS04_RS07185	COG1058	Belongs to the CinA family
BHS04_RS07185	COG1546	Belongs to the CinA family
BHS04_RS07205	COG1252	NADH dehydrogenase
BHS04_RS07210	COG0606	chelatase, subunit chli
BHS04_RS07280	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
BHS04_RS07285	COG0116	Belongs to the methyltransferase superfamily
BHS04_RS07285	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BHS04_RS07305	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BHS04_RS07310	COG0154	amidase activity
BHS04_RS07315	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BHS04_RS07340	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BHS04_RS07345	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BHS04_RS07350	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BHS04_RS07375	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BHS04_RS07385	COG1666	GTP binding
BHS04_RS07390	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BHS04_RS07395	COG0515	serine threonine protein kinase
BHS04_RS07415	COG0542	response to heat
BHS04_RS07510	COG1515	deoxyribonuclease V activity
BHS04_RS07540	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BHS04_RS07575	COG0210	DNA helicase
BHS04_RS07590	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
BHS04_RS07600	COG1690	Belongs to the RtcB family
BHS04_RS07615	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BHS04_RS07625	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BHS04_RS07630	COG0318	PFAM AMP-dependent synthetase and ligase
BHS04_RS07670	COG2967	ApaG domain
BHS04_RS07690	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BHS04_RS07710	COG0009	L-threonylcarbamoyladenylate synthase
BHS04_RS07715	COG1090	epimerase
BHS04_RS07750	COG2205	protein histidine kinase activity
BHS04_RS07750	COG2202	Pas domain
BHS04_RS07760	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BHS04_RS07760	COG0723	plastoquinol--plastocyanin reductase activity
BHS04_RS07775	COG2814	Major facilitator Superfamily
BHS04_RS07780	COG0531	amino acid
BHS04_RS07785	COG2264	protein methyltransferase activity
BHS04_RS07810	COG0450	alkyl hydroperoxide reductase
BHS04_RS07820	COG3604	Transcriptional regulator
BHS04_RS07845	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
BHS04_RS07855	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BHS04_RS07865	COG1045	serine acetyltransferase
BHS04_RS07870	COG0318	PFAM AMP-dependent synthetase and ligase
BHS04_RS07880	COG0583	DNA-binding transcription factor activity
BHS04_RS07885	COG0477	Major facilitator Superfamily
BHS04_RS07890	COG2815	serine threonine protein kinase
BHS04_RS07890	COG0515	serine threonine protein kinase
BHS04_RS07900	COG1238	metal cluster binding
BHS04_RS07910	COG0628	permease
BHS04_RS07940	COG1187	pseudouridine synthase activity
BHS04_RS07955	COG0512	Glutamine amidotransferase of anthranilate synthase
BHS04_RS07960	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BHS04_RS07995	COG1131	(ABC) transporter
BHS04_RS08005	COG2264	protein methyltransferase activity
BHS04_RS08015	COG0300	oxidoreductase activity
BHS04_RS08015	COG1028	Short-chain dehydrogenase reductase Sdr
BHS04_RS08015	COG3321	synthase
BHS04_RS08015	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BHS04_RS08015	COG0318	PFAM AMP-dependent synthetase and ligase
BHS04_RS08020	COG4591	ABC-type transport system involved in lipoprotein release permease component
BHS04_RS08025	COG0577	efflux transmembrane transporter activity
BHS04_RS08055	COG2010	Cytochrome c
BHS04_RS08085	COG1278	Cold shock
BHS04_RS08095	COG2378	regulation of single-species biofilm formation
BHS04_RS08165	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BHS04_RS08185	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BHS04_RS08215	COG2267	carboxylic ester hydrolase activity
BHS04_RS08225	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
BHS04_RS08240	COG3275	phosphorelay sensor kinase activity
BHS04_RS08245	COG3279	Response regulator of the LytR AlgR family
BHS04_RS08340	COG2814	Major facilitator Superfamily
BHS04_RS08355	COG0179	Fumarylacetoacetate (FAA) hydrolase
BHS04_RS08360	COG1802	Transcriptional regulator
BHS04_RS08440	COG2937	Belongs to the GPAT DAPAT family
BHS04_RS08445	COG0277	FAD linked oxidase domain protein
BHS04_RS08450	COG1309	transcriptional regulator
BHS04_RS08460	COG0642	Histidine kinase
BHS04_RS08475	COG0823	Involved in the tonB-independent uptake of proteins
BHS04_RS08475	COG1506	peptidase
BHS04_RS08480	COG0583	DNA-binding transcription factor activity
BHS04_RS08565	COG1309	transcriptional regulator
BHS04_RS08570	COG1733	regulation of RNA biosynthetic process
BHS04_RS08585	COG0577	efflux transmembrane transporter activity
BHS04_RS08585	COG1136	(ABC) transporter
BHS04_RS08590	COG3848	Pyruvate phosphate dikinase
BHS04_RS08590	COG0574	Belongs to the PEP-utilizing enzyme family
BHS04_RS08610	COG0596	Alpha beta hydrolase
BHS04_RS08625	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BHS04_RS08655	COG2801	Transposase and inactivated derivatives
BHS04_RS08675	COG2801	Transposase and inactivated derivatives
BHS04_RS08695	COG0515	serine threonine protein kinase
BHS04_RS08695	COG0457	Tetratricopeptide repeat
BHS04_RS08750	COG0590	tRNA wobble adenosine to inosine editing
BHS04_RS08770	COG0583	DNA-binding transcription factor activity
BHS04_RS08800	COG0640	Transcriptional regulator
BHS04_RS08810	COG1073	alpha beta
BHS04_RS08830	COG2815	serine threonine protein kinase
BHS04_RS08830	COG0515	serine threonine protein kinase
BHS04_RS08880	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BHS04_RS08935	COG1741	Belongs to the pirin family
BHS04_RS09025	COG2801	Transposase and inactivated derivatives
BHS04_RS09070	COG3436	PFAM IS66 Orf2 family protein
BHS04_RS09100	COG1132	(ABC) transporter
BHS04_RS09105	COG1132	(ABC) transporter
BHS04_RS09120	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BHS04_RS09145	COG3436	PFAM IS66 Orf2 family protein
BHS04_RS09175	COG3436	PFAM IS66 Orf2 family protein
BHS04_RS09220	COG1309	transcriptional regulator
BHS04_RS09285	COG2801	Transposase and inactivated derivatives
BHS04_RS09325	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BHS04_RS09340	COG1714	RDD family
BHS04_RS09505	COG2801	Transposase and inactivated derivatives
BHS04_RS09630	COG4653	Phage capsid family
BHS04_RS09640	COG0338	D12 class N6 adenine-specific DNA methyltransferase
BHS04_RS09655	COG5518	Phage portal protein
BHS04_RS09680	COG3436	PFAM IS66 Orf2 family protein
BHS04_RS09690	COG3436	PFAM IS66 Orf2 family protein
BHS04_RS09740	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BHS04_RS09755	COG2801	Transposase and inactivated derivatives
BHS04_RS09770	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BHS04_RS09770	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BHS04_RS09775	COG1619	proteins homologs of microcin C7 resistance protein MccF
BHS04_RS09780	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BHS04_RS09785	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BHS04_RS09790	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BHS04_RS09795	COG0483	inositol monophosphate 1-phosphatase activity
BHS04_RS09815	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BHS04_RS09850	COG1100	Small GTP-binding protein
BHS04_RS09870	COG0515	serine threonine protein kinase
BHS04_RS09875	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BHS04_RS09880	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BHS04_RS09890	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BHS04_RS09915	COG0590	tRNA wobble adenosine to inosine editing
BHS04_RS09935	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BHS04_RS09965	COG1088	dTDP-glucose 4,6-dehydratase activity
BHS04_RS09980	COG0514	ATP-dependent DNA helicase (RecQ)
BHS04_RS09990	COG2003	Belongs to the UPF0758 family
BHS04_RS09995	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BHS04_RS10000	COG0492	ferredoxin-NADP+ reductase activity
BHS04_RS10005	COG0626	cystathionine gamma-synthase activity
BHS04_RS10010	COG0315	cyclic pyranopterin monophosphate synthase activity
BHS04_RS10050	COG1832	CoA-binding protein
BHS04_RS10070	COG2226	methyltransferase
BHS04_RS10075	COG1410	methionine synthase
BHS04_RS10075	COG0646	methionine synthase
BHS04_RS10105	COG1028	Short-chain dehydrogenase reductase Sdr
BHS04_RS10115	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BHS04_RS10150	COG0424	maF-like protein
BHS04_RS10175	COG0210	DNA helicase
BHS04_RS10200	COG2137	regulation of response to DNA damage stimulus
BHS04_RS10225	COG0709	Synthesizes selenophosphate from selenide and ATP
BHS04_RS10230	COG0860	N-Acetylmuramoyl-L-alanine amidase
BHS04_RS10235	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
BHS04_RS10240	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BHS04_RS10280	COG0544	peptidyl-prolyl cis-trans isomerase activity
BHS04_RS10285	COG0740	serine-type endopeptidase activity
BHS04_RS10295	COG1505	serine-type exopeptidase activity
BHS04_RS10305	COG4166	transmembrane transport
BHS04_RS10325	COG1678	Uncharacterized ACR, COG1678
BHS04_RS10330	COG0271	Belongs to the BolA IbaG family
BHS04_RS10335	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
BHS04_RS10345	COG0006	proline dipeptidase activity
BHS04_RS10355	COG3148	PFAM DTW domain containing protein
BHS04_RS10365	COG1595	DNA-templated transcription, initiation
BHS04_RS10380	COG1573	uracil-dna glycosylase
BHS04_RS10385	COG1024	Enoyl-CoA hydratase
BHS04_RS10390	COG0626	cystathionine gamma-synthase activity
BHS04_RS10410	COG2030	dehydratase
BHS04_RS10425	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
BHS04_RS10430	COG0631	protein serine/threonine phosphatase activity
BHS04_RS10440	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BHS04_RS10455	COG0484	heat shock protein binding
BHS04_RS10465	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BHS04_RS10470	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BHS04_RS10480	COG1428	Deoxynucleoside kinase
BHS04_RS10485	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
BHS04_RS10490	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
BHS04_RS10495	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BHS04_RS10515	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
BHS04_RS10535	COG0779	Required for maturation of 30S ribosomal subunits
BHS04_RS10550	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BHS04_RS10560	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BHS04_RS10565	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BHS04_RS10570	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BHS04_RS10575	COG1185	polyribonucleotide nucleotidyltransferase activity
BHS04_RS10585	COG0739	heme binding
BHS04_RS10590	COG0756	dUTP diphosphatase activity
BHS04_RS10605	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BHS04_RS10630	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BHS04_RS10645	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BHS04_RS10665	COG0612	Peptidase, M16
BHS04_RS10675	COG4974	Belongs to the 'phage' integrase family
BHS04_RS10680	COG1228	amidohydrolase
BHS04_RS10705	COG2356	endonuclease I
BHS04_RS10730	COG1309	transcriptional regulator
BHS04_RS10745	COG1643	Atp-dependent helicase
BHS04_RS10755	COG1063	alcohol dehydrogenase
BHS04_RS10785	COG2130	NADP-dependent
BHS04_RS10880	COG4999	Histidine kinase
BHS04_RS10880	COG3850	Histidine kinase
BHS04_RS10880	COG3437	response regulator, receiver
BHS04_RS10880	COG2205	protein histidine kinase activity
BHS04_RS10970	COG1250	3-hydroxyacyl-CoA dehydrogenase
BHS04_RS10995	COG4584	PFAM Integrase catalytic
BHS04_RS10995	COG2390	Transcriptional regulator
BHS04_RS11000	COG1752	Esterase of the alpha-beta hydrolase superfamily
BHS04_RS11015	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BHS04_RS11035	COG2133	pyrroloquinoline quinone binding
BHS04_RS11065	COG0657	acetylesterase activity
BHS04_RS11110	COG1268	BioY protein
BHS04_RS11165	COG0596	Alpha beta hydrolase
BHS04_RS11230	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BHS04_RS11270	COG3226	Transcriptional regulator
BHS04_RS11280	COG0737	Belongs to the 5'-nucleotidase family
BHS04_RS11315	COG2226	methyltransferase
BHS04_RS11325	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BHS04_RS11330	COG0277	FAD linked oxidase domain protein
BHS04_RS11370	COG4176	ABC-type proline glycine betaine transport system permease component
BHS04_RS11375	COG2113	Glycine betaine
BHS04_RS11380	COG3869	Catalyzes the specific phosphorylation of arginine residues in
BHS04_RS11400	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BHS04_RS11410	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BHS04_RS11420	COG4651	solute:proton antiporter activity
BHS04_RS11420	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BHS04_RS11430	COG1703	isobutyryl-CoA mutase activity
BHS04_RS11430	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BHS04_RS11430	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BHS04_RS11435	COG1703	isobutyryl-CoA mutase activity
BHS04_RS11450	COG0328	RNA-DNA hybrid ribonuclease activity
BHS04_RS11455	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
BHS04_RS11460	COG2070	2-Nitropropane dioxygenase
BHS04_RS11465	COG1136	(ABC) transporter
BHS04_RS11465	COG0577	efflux transmembrane transporter activity
BHS04_RS11525	COG0460	homoserine dehydrogenase
BHS04_RS11525	COG0527	aspartate kinase activity
BHS04_RS11530	COG0306	phosphate transporter
BHS04_RS11540	COG3321	synthase
BHS04_RS11540	COG1028	Short-chain dehydrogenase reductase Sdr
BHS04_RS11540	COG0604	alcohol dehydrogenase
BHS04_RS11545	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BHS04_RS11555	COG0427	acetyl-CoA hydrolase
BHS04_RS11560	COG0339	signal peptide processing
BHS04_RS11565	COG0351	phosphomethylpyrimidine kinase
BHS04_RS11575	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BHS04_RS11605	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
BHS04_RS11620	COG0017	Asparaginyl-tRNA synthetase
BHS04_RS11665	COG2124	cytochrome p450
BHS04_RS11675	COG0813	purine-nucleoside phosphorylase activity
BHS04_RS11690	COG0513	Belongs to the DEAD box helicase family
BHS04_RS11715	COG1063	alcohol dehydrogenase
BHS04_RS11730	COG3850	Histidine kinase
BHS04_RS11730	COG2205	protein histidine kinase activity
BHS04_RS11730	COG4999	Histidine kinase
BHS04_RS11730	COG3437	response regulator, receiver
BHS04_RS11745	COG3541	Predicted nucleotidyltransferase
BHS04_RS11765	COG3228	Belongs to the MtfA family
BHS04_RS11770	COG1072	(Pantothenic acid kinase))
BHS04_RS11780	COG2153	protein acetylation
BHS04_RS11790	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BHS04_RS11800	COG0741	lytic transglycosylase activity
BHS04_RS11800	COG0739	heme binding
BHS04_RS11800	COG1196	nuclear chromosome segregation
BHS04_RS11815	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BHS04_RS11820	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BHS04_RS11825	COG2895	sulfate adenylyltransferase (ATP) activity
BHS04_RS11830	COG0175	sulfate reduction
BHS04_RS11835	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BHS04_RS11835	COG1648	precorrin-2 dehydrogenase activity
BHS04_RS11840	COG1648	precorrin-2 dehydrogenase activity
BHS04_RS11840	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BHS04_RS11845	COG0175	sulfate reduction
BHS04_RS11880	COG0047	phosphoribosylformylglycinamidine synthase activity
BHS04_RS11880	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BHS04_RS11885	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BHS04_RS11890	COG0517	IMP dehydrogenase activity
BHS04_RS11895	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BHS04_RS11930	COG0019	diaminopimelate decarboxylase activity
BHS04_RS11935	COG1215	transferase activity, transferring glycosyl groups
BHS04_RS11945	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
BHS04_RS11955	COG0438	transferase activity, transferring glycosyl groups
BHS04_RS11960	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BHS04_RS11985	COG5002	protein histidine kinase activity
BHS04_RS11990	COG1218	3'(2'),5'-bisphosphate nucleotidase
BHS04_RS12000	COG3663	DNA glycosylase
BHS04_RS12015	COG1228	amidohydrolase
BHS04_RS12025	COG2363	Small membrane protein
BHS04_RS12060	COG2943	transferase activity, transferring hexosyl groups
BHS04_RS12070	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
BHS04_RS12085	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BHS04_RS12090	COG0386	Belongs to the glutathione peroxidase family
BHS04_RS12130	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BHS04_RS12145	COG0515	serine threonine protein kinase
BHS04_RS12145	COG3064	Membrane
BHS04_RS12145	COG4991	sh3 domain protein
BHS04_RS12165	COG1301	dicarboxylic acid transport
BHS04_RS12170	COG1047	Peptidyl-prolyl cis-trans
BHS04_RS12185	COG0488	(ABC) transporter
BHS04_RS12190	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BHS04_RS12210	COG1187	pseudouridine synthase activity
BHS04_RS12235	COG2373	Large extracellular alpha-helical protein
BHS04_RS12240	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BHS04_RS12245	COG4953	penicillin-binding protein 1C
BHS04_RS12270	COG4943	cyclic-guanylate-specific phosphodiesterase activity
BHS04_RS12290	COG1136	(ABC) transporter
BHS04_RS12290	COG0577	efflux transmembrane transporter activity
BHS04_RS12300	COG1136	(ABC) transporter
BHS04_RS12335	COG1191	sigma factor activity
BHS04_RS12390	COG1987	bacterial-type flagellum assembly
BHS04_RS12400	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BHS04_RS12405	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BHS04_RS12460	COG4789	Type iii secretion
BHS04_RS12465	COG1716	ATPase activity
BHS04_RS12510	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BHS04_RS12520	COG0714	Associated with various cellular activities
BHS04_RS12545	COG0616	signal peptide processing
BHS04_RS12560	COG0187	DNA topoisomerase II activity
BHS04_RS12565	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BHS04_RS12575	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BHS04_RS12680	COG1459	type II secretion system
BHS04_RS12710	COG0312	modulator of DNA gyrase
BHS04_RS12715	COG0312	modulator of DNA gyrase
BHS04_RS12725	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BHS04_RS12745	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BHS04_RS12785	COG3300	MHYT domain
BHS04_RS12785	COG5001	Diguanylate cyclase
BHS04_RS12800	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BHS04_RS12805	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BHS04_RS12810	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BHS04_RS12815	COG1022	Amp-dependent synthetase and ligase
BHS04_RS12850	COG0416	fatty acid biosynthetic process
BHS04_RS12865	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BHS04_RS12875	COG0564	pseudouridine synthase activity
BHS04_RS12910	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BHS04_RS12915	COG4589	Belongs to the CDS family
BHS04_RS12920	COG0750	zinc metalloprotease
BHS04_RS12925	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BHS04_RS12930	COG1214	PFAM Peptidase M22, glycoprotease
BHS04_RS12935	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BHS04_RS12955	COG0314	molybdopterin synthase activity
BHS04_RS12985	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BHS04_RS12995	COG0406	alpha-ribazole phosphatase activity
BHS04_RS13005	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BHS04_RS13025	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BHS04_RS13025	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BHS04_RS13065	COG0515	serine threonine protein kinase
BHS04_RS13075	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BHS04_RS13095	COG0584	glycerophosphoryl diester phosphodiesterase
BHS04_RS13145	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
BHS04_RS13165	COG3104	oligopeptide transport
BHS04_RS13190	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BHS04_RS13210	COG0456	acetyltransferase
BHS04_RS13220	COG1074	ATP-dependent DNA helicase activity
BHS04_RS13225	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BHS04_RS13265	COG0658	competence protein
BHS04_RS13265	COG2333	competence protein COMEC
BHS04_RS13270	COG1329	Transcriptional regulator
BHS04_RS13295	COG0556	nucleotide-excision repair
BHS04_RS13300	COG0322	excinuclease ABC activity
BHS04_RS13325	COG3487	Iron-regulated protein
BHS04_RS13360	COG0424	maF-like protein
BHS04_RS13365	COG3706	GGDEF domain
BHS04_RS13370	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BHS04_RS13390	COG0772	Belongs to the SEDS family
BHS04_RS13410	COG3118	belongs to the thioredoxin family
BHS04_RS13425	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
BHS04_RS13430	COG0181	hydroxymethylbilane synthase activity
BHS04_RS13435	COG1587	Uroporphyrinogen-III synthase
BHS04_RS13440	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BHS04_RS13480	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BHS04_RS13485	COG0022	dehydrogenase e1 component
BHS04_RS13490	COG0508	dehydrogenase complex catalyzes the overall conversion of
BHS04_RS13505	COG3852	Histidine kinase
BHS04_RS13535	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BHS04_RS13580	COG0784	Response regulator, receiver
BHS04_RS13630	COG1100	Small GTP-binding protein
BHS04_RS13635	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BHS04_RS13645	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BHS04_RS13650	COG1024	Enoyl-CoA hydratase
BHS04_RS13655	COG1683	Conserved Protein
BHS04_RS13660	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BHS04_RS13665	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BHS04_RS13670	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BHS04_RS13680	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
BHS04_RS13685	COG0285	dihydrofolate synthase activity
BHS04_RS13705	COG1396	sequence-specific DNA binding
BHS04_RS13715	COG1309	transcriptional regulator
BHS04_RS13720	COG1024	Enoyl-CoA hydratase
BHS04_RS13775	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
BHS04_RS13785	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BHS04_RS13790	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
BHS04_RS13795	COG1034	ATP synthesis coupled electron transport
BHS04_RS13800	COG0649	NAD binding
BHS04_RS13805	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BHS04_RS13815	COG3119	arylsulfatase activity
BHS04_RS13825	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BHS04_RS13830	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BHS04_RS13845	COG3119	arylsulfatase activity
BHS04_RS13860	COG0613	PHP domain protein
BHS04_RS13880	COG1166	arginine decarboxylase activity
BHS04_RS13895	COG0484	heat shock protein binding
BHS04_RS13910	COG0443	Heat shock 70 kDa protein
BHS04_RS13960	COG1796	DNA polymerase
BHS04_RS13960	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
BHS04_RS13970	COG0521	Mo-molybdopterin cofactor biosynthetic process
BHS04_RS13990	COG4191	Histidine kinase
BHS04_RS14000	COG1233	COG1233 Phytoene dehydrogenase and related
BHS04_RS14035	COG0577	efflux transmembrane transporter activity
BHS04_RS14035	COG1136	(ABC) transporter
BHS04_RS14055	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
BHS04_RS14065	COG0534	Mate efflux family protein
BHS04_RS14100	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BHS04_RS14120	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BHS04_RS14145	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BHS04_RS14145	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BHS04_RS14155	COG0084	hydrolase, TatD family'
BHS04_RS14165	COG3481	metal-dependent phosphohydrolase, HD sub domain
BHS04_RS14170	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BHS04_RS14180	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
BHS04_RS14190	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
BHS04_RS14200	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BHS04_RS14205	COG0126	phosphoglycerate kinase activity
BHS04_RS14210	COG0149	triose-phosphate isomerase activity
BHS04_RS14275	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BHS04_RS14305	COG1595	DNA-templated transcription, initiation
BHS04_RS14335	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BHS04_RS14340	COG1116	anion transmembrane transporter activity
BHS04_RS14380	COG1012	belongs to the aldehyde dehydrogenase family
BHS04_RS14385	COG0583	DNA-binding transcription factor activity
BHS04_RS14395	COG1012	belongs to the aldehyde dehydrogenase family
BHS04_RS14400	COG1739	Uncharacterized protein family UPF0029
BHS04_RS14405	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BHS04_RS14475	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BHS04_RS14525	COG1309	transcriptional regulator
BHS04_RS14540	COG2072	flavoprotein involved in K transport
BHS04_RS14555	COG0628	permease
BHS04_RS14575	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BHS04_RS14660	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BHS04_RS14705	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BHS04_RS14745	COG2366	antibiotic biosynthetic process
BHS04_RS14750	COG1183	phosphatidylcholine synthase activity
BHS04_RS14765	COG0515	serine threonine protein kinase
BHS04_RS14770	COG0515	serine threonine protein kinase
BHS04_RS14780	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BHS04_RS14785	COG0138	bifunctional purine biosynthesis protein purh
BHS04_RS14795	COG0151	Belongs to the GarS family
BHS04_RS14815	COG0438	transferase activity, transferring glycosyl groups
BHS04_RS14825	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BHS04_RS14835	COG1215	transferase activity, transferring glycosyl groups
BHS04_RS14840	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BHS04_RS14930	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BHS04_RS14935	COG1120	ATPase activity
BHS04_RS14965	COG0302	gtp cyclohydrolase
BHS04_RS14970	COG0277	FAD linked oxidase domain protein
BHS04_RS14990	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BHS04_RS15000	COG0745	RESPONSE REGULATOR receiver
BHS04_RS15010	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BHS04_RS15020	COG1846	Transcriptional regulator
BHS04_RS15035	COG1960	acyl-CoA dehydrogenase activity
BHS04_RS15040	COG1301	dicarboxylic acid transport
BHS04_RS15055	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
BHS04_RS15070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BHS04_RS15075	COG1692	metallophosphoesterase
BHS04_RS15095	COG0515	serine threonine protein kinase
BHS04_RS15105	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
BHS04_RS15110	COG5002	protein histidine kinase activity
BHS04_RS15155	COG1196	nuclear chromosome segregation
BHS04_RS15155	COG0745	RESPONSE REGULATOR receiver
BHS04_RS15170	COG1543	Belongs to the glycosyl hydrolase 57 family
BHS04_RS15175	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BHS04_RS15190	COG1496	oxidoreductase activity
BHS04_RS15210	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BHS04_RS15235	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
BHS04_RS15260	COG0490	domain, Protein
BHS04_RS15260	COG0471	metal ion transport
BHS04_RS15265	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
BHS04_RS15270	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
BHS04_RS15280	COG0484	heat shock protein binding
BHS04_RS15285	COG0443	Heat shock 70 kDa protein
BHS04_RS15310	COG0237	dephospho-CoA kinase activity
BHS04_RS15325	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BHS04_RS15350	COG0167	dihydroorotate dehydrogenase activity
BHS04_RS15365	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
BHS04_RS15370	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BHS04_RS15405	COG3852	Histidine kinase
BHS04_RS15420	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BHS04_RS15430	COG0509	glycine decarboxylation via glycine cleavage system
BHS04_RS15435	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BHS04_RS15435	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BHS04_RS15440	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BHS04_RS15465	COG1960	acyl-CoA dehydrogenase activity
BHS04_RS15475	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BHS04_RS15500	COG1643	Atp-dependent helicase
BHS04_RS15530	COG0189	ligase activity
BHS04_RS15540	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BHS04_RS15565	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BHS04_RS15570	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BHS04_RS15590	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BHS04_RS15595	COG0081	regulation of translation
BHS04_RS15600	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BHS04_RS15605	COG0222	ribosome binding
BHS04_RS15610	COG0085	RNA polymerase activity
BHS04_RS15615	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BHS04_RS15630	COG1196	nuclear chromosome segregation
BHS04_RS15630	COG0739	heme binding
BHS04_RS15630	COG0741	lytic transglycosylase activity
BHS04_RS15655	COG1381	Involved in DNA repair and RecF pathway recombination
BHS04_RS15680	COG0515	serine threonine protein kinase
BHS04_RS15680	COG2815	serine threonine protein kinase
BHS04_RS15695	COG3604	Transcriptional regulator
BHS04_RS15710	COG5002	protein histidine kinase activity
BHS04_RS15715	COG0515	serine threonine protein kinase
BHS04_RS15720	COG0752	glycyl-tRNA synthetase alpha subunit
BHS04_RS15725	COG0751	glycine-tRNA ligase activity
BHS04_RS15750	COG1450	Type ii and iii secretion system protein
BHS04_RS15825	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BHS04_RS15875	COG1505	serine-type exopeptidase activity
BHS04_RS15905	COG2205	protein histidine kinase activity
BHS04_RS15905	COG0784	Response regulator, receiver
BHS04_RS15945	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
BHS04_RS15945	COG3608	succinylglutamate desuccinylase aspartoacylase
BHS04_RS15965	COG2311	Membrane
BHS04_RS15970	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BHS04_RS15995	COG4302	ethanolamine ammonia-lyase activity
BHS04_RS16030	COG3590	peptidase
BHS04_RS16040	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
BHS04_RS16040	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
BHS04_RS16085	COG2354	Protein conserved in bacteria
BHS04_RS16095	COG2130	NADP-dependent
BHS04_RS16105	COG0330	HflC and HflK could
BHS04_RS16160	COG1643	Atp-dependent helicase
BHS04_RS16185	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BHS04_RS16195	COG3436	PFAM IS66 Orf2 family protein
BHS04_RS16210	COG4584	PFAM Integrase catalytic
BHS04_RS16215	COG1484	DNA-dependent DNA replication
BHS04_RS16245	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BHS04_RS16255	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
BHS04_RS16260	COG2921	Belongs to the UPF0250 family
BHS04_RS16275	COG0443	Heat shock 70 kDa protein
BHS04_RS16340	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BHS04_RS16340	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
BHS04_RS16345	COG0425	Belongs to the sulfur carrier protein TusA family
BHS04_RS16350	COG1131	(ABC) transporter
BHS04_RS16360	COG0768	penicillin binding
BHS04_RS16380	COG2204	response regulator
BHS04_RS16385	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BHS04_RS16405	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
BHS04_RS16410	COG1605	Chorismate mutase
BHS04_RS16410	COG0077	Prephenate dehydratase
BHS04_RS16415	COG0077	Prephenate dehydratase
BHS04_RS16415	COG1605	Chorismate mutase
BHS04_RS16420	COG2153	protein acetylation
BHS04_RS16450	COG0489	protein tyrosine kinase activity
BHS04_RS16455	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BHS04_RS16460	COG0391	Required for morphogenesis under gluconeogenic growth conditions
BHS04_RS16485	COG3088	subunit of a heme lyase
BHS04_RS16490	COG3173	Aminoglycoside phosphotransferase
BHS04_RS16500	COG2755	lipolytic protein G-D-S-L family
BHS04_RS16500	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
BHS04_RS16515	COG5507	3-demethylubiquinone-9 3-methyltransferase
BHS04_RS16540	COG2205	protein histidine kinase activity
BHS04_RS16590	COG3811	Belongs to the UPF0386 family
BHS04_RS16605	COG2755	lipolytic protein G-D-S-L family
BHS04_RS16605	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
BHS04_RS16615	COG0318	PFAM AMP-dependent synthetase and ligase
BHS04_RS16660	COG1024	Enoyl-CoA hydratase
BHS04_RS16690	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BHS04_RS16695	COG1138	Cytochrome C-type biogenesis protein
BHS04_RS16700	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
BHS04_RS16720	COG1131	(ABC) transporter
BHS04_RS16765	COG0352	thiamine-phosphate diphosphorylase activity
BHS04_RS16770	COG2022	thiamine diphosphate biosynthetic process
BHS04_RS16825	COG2267	carboxylic ester hydrolase activity
BHS04_RS16830	COG0598	Magnesium transport protein CorA
BHS04_RS16890	COG0018	arginyl-trna synthetase
BHS04_RS16895	COG5002	protein histidine kinase activity
BHS04_RS16920	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BHS04_RS16925	COG0049	tRNA binding
BHS04_RS16930	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BHS04_RS16935	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BHS04_RS16940	COG0051	transcription antitermination factor activity, RNA binding
BHS04_RS16945	COG0088	Forms part of the polypeptide exit tunnel
BHS04_RS16950	COG0089	rRNA binding
BHS04_RS16955	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BHS04_RS16960	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BHS04_RS16965	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BHS04_RS16970	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BHS04_RS16975	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BHS04_RS16980	COG0255	Belongs to the universal ribosomal protein uL29 family
BHS04_RS16985	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BHS04_RS16990	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BHS04_RS16995	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BHS04_RS17005	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BHS04_RS17010	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BHS04_RS17015	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BHS04_RS17020	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BHS04_RS17025	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BHS04_RS17030	COG1841	ribosomal large subunit assembly
BHS04_RS17035	COG0200	Binds to the 23S rRNA
BHS04_RS17040	COG0201	protein transport
BHS04_RS17045	COG0563	adenylate kinase activity
BHS04_RS17050	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BHS04_RS17055	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BHS04_RS17060	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BHS04_RS17065	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BHS04_RS17070	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BHS04_RS17075	COG0202	RNA polymerase activity
BHS04_RS17080	COG0203	ribosomal protein L17
BHS04_RS17110	COG3604	Transcriptional regulator
BHS04_RS17120	COG2313	pseudouridylate synthase activity
BHS04_RS17125	COG1956	GAF domain-containing protein
BHS04_RS17140	COG0488	(ABC) transporter
BHS04_RS17155	COG0741	lytic transglycosylase activity
BHS04_RS17160	COG1278	Cold shock
BHS04_RS17190	COG0564	pseudouridine synthase activity
BHS04_RS17210	COG1297	OPT oligopeptide transporter protein
BHS04_RS17215	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BHS04_RS17230	COG0714	Associated with various cellular activities
BHS04_RS17240	COG1196	nuclear chromosome segregation
BHS04_RS17240	COG0741	lytic transglycosylase activity
BHS04_RS17240	COG0739	heme binding
BHS04_RS17270	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BHS04_RS17315	COG1217	gtp-binding protein TYPA
BHS04_RS17320	COG0596	Alpha beta hydrolase
BHS04_RS17325	COG2204	response regulator
BHS04_RS17340	COG0742	ribosomal rna small subunit methyltransferase
BHS04_RS17345	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BHS04_RS17350	COG0436	Aminotransferase
BHS04_RS17360	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BHS04_RS17365	COG1902	pentaerythritol trinitrate reductase activity
BHS04_RS17395	COG0242	peptide deformylase activity
BHS04_RS17450	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BHS04_RS17455	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BHS04_RS17465	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BHS04_RS17470	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BHS04_RS17470	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BHS04_RS17480	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BHS04_RS17505	COG4191	Histidine kinase
BHS04_RS17510	COG2132	Multicopper oxidase
BHS04_RS17535	COG2132	Multicopper oxidase
BHS04_RS17545	COG2217	Heavy metal translocating P-type atpase
BHS04_RS17565	COG0667	Aldo Keto reductase
BHS04_RS17635	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BHS04_RS17675	COG1546	Belongs to the CinA family
BHS04_RS17675	COG1058	Belongs to the CinA family
BHS04_RS17695	COG3590	peptidase
BHS04_RS17750	COG0745	RESPONSE REGULATOR receiver
BHS04_RS17755	COG5002	protein histidine kinase activity
BHS04_RS17775	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BHS04_RS17790	COG3791	Glutathione-dependent formaldehyde-activating
BHS04_RS17795	COG0673	inositol 2-dehydrogenase activity
BHS04_RS17825	COG2986	histidine ammonia-lyase
BHS04_RS17830	COG0527	aspartate kinase activity
BHS04_RS17855	COG1215	transferase activity, transferring glycosyl groups
BHS04_RS17870	COG0210	DNA helicase
BHS04_RS17875	COG0443	Heat shock 70 kDa protein
BHS04_RS17905	COG2146	nitrite reductase [NAD(P)H] activity
BHS04_RS17905	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
BHS04_RS17940	COG0529	Catalyzes the synthesis of activated sulfate
BHS04_RS17945	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
BHS04_RS18195	COG3436	PFAM IS66 Orf2 family protein
BHS04_RS18260	COG3239	Fatty acid desaturase
BHS04_RS18275	COG0617	tRNA 3'-terminal CCA addition
BHS04_RS18280	COG0482	sulfurtransferase activity
BHS04_RS18290	COG0776	regulation of translation
BHS04_RS18325	COG0481	GTPase activity
BHS04_RS18330	COG0681	Belongs to the peptidase S26 family
BHS04_RS18335	COG0540	Belongs to the ATCase OTCase family
BHS04_RS18345	COG0505	Belongs to the CarA family
BHS04_RS18370	COG1022	Amp-dependent synthetase and ligase
BHS04_RS18375	COG0372	Belongs to the citrate synthase family
BHS04_RS18380	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BHS04_RS18385	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BHS04_RS18390	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BHS04_RS18405	COG2226	methyltransferase
BHS04_RS18410	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
BHS04_RS18420	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
BHS04_RS18435	COG4948	Mandelate Racemase Muconate Lactonizing
BHS04_RS18465	COG5002	protein histidine kinase activity
BHS04_RS18470	COG0538	isocitrate dehydrogenase activity
BHS04_RS18480	COG1053	succinate dehydrogenase
BHS04_RS18485	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BHS04_RS18490	COG0045	succinate-CoA ligase (ADP-forming) activity
BHS04_RS18495	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BHS04_RS18505	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BHS04_RS18510	COG0228	four-way junction DNA binding
BHS04_RS18515	COG1837	Belongs to the UPF0109 family
BHS04_RS18520	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BHS04_RS18525	COG0336	Belongs to the RNA methyltransferase TrmD family
BHS04_RS18530	COG0335	large ribosomal subunit rRNA binding
BHS04_RS18540	COG0792	nuclease activity
BHS04_RS18545	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
BHS04_RS18560	COG2204	response regulator
BHS04_RS18575	COG0728	peptidoglycan biosynthetic process
BHS04_RS18605	COG1404	Belongs to the peptidase S8 family
BHS04_RS18615	COG0154	amidase activity
BHS04_RS18650	COG2255	four-way junction helicase activity
BHS04_RS18655	COG4305	rare lipoprotein A
BHS04_RS18660	COG2304	oxidoreductase activity
BHS04_RS18680	COG1028	Short-chain dehydrogenase reductase Sdr
BHS04_RS18715	COG1278	Cold shock
BHS04_RS18725	COG0545	Peptidyl-prolyl cis-trans isomerase
BHS04_RS18745	COG0628	permease
BHS04_RS18760	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BHS04_RS18765	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BHS04_RS18770	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BHS04_RS18775	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BHS04_RS18780	COG0072	phenylalanine-tRNA ligase activity
BHS04_RS18785	COG0776	regulation of translation
BHS04_RS18860	COG0438	transferase activity, transferring glycosyl groups
BHS04_RS18875	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BHS04_RS18920	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BHS04_RS18930	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
BHS04_RS18935	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BHS04_RS18940	COG1535	isochorismatase
BHS04_RS18940	COG3433	isochorismatase activity
BHS04_RS18945	COG1021	2,3-dihydroxybenzoate-AMP ligase
BHS04_RS18950	COG1169	isochorismate synthase
BHS04_RS18955	COG1028	Short-chain dehydrogenase reductase Sdr
BHS04_RS18970	COG1136	(ABC) transporter
BHS04_RS18970	COG0577	efflux transmembrane transporter activity
BHS04_RS19000	COG3973	AAA domain
BHS04_RS19030	COG3436	PFAM IS66 Orf2 family protein
BHS04_RS19040	COG3436	PFAM IS66 Orf2 family protein
BHS04_RS19065	COG1484	DNA-dependent DNA replication
BHS04_RS19070	COG0156	8-amino-7-oxononanoate synthase activity
BHS04_RS19090	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BHS04_RS19105	COG2076	Multidrug Resistance protein
BHS04_RS19125	COG1335	isochorismatase
BHS04_RS19145	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BHS04_RS19165	COG0640	Transcriptional regulator
BHS04_RS19170	COG0477	Major facilitator Superfamily
BHS04_RS19175	COG3227	Zinc metalloprotease (Elastase)
BHS04_RS19205	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BHS04_RS19220	COG0366	Alpha amylase catalytic
BHS04_RS19225	COG1595	DNA-templated transcription, initiation
BHS04_RS19240	COG5002	protein histidine kinase activity
BHS04_RS19275	COG0515	serine threonine protein kinase
BHS04_RS19320	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BHS04_RS19340	COG2521	methyltransferase
BHS04_RS19340	COG2136	Putative SAM-dependent methyltransferase
BHS04_RS19360	COG2197	response regulator
BHS04_RS19365	COG0612	Peptidase, M16
BHS04_RS19375	COG0564	pseudouridine synthase activity
BHS04_RS19390	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BHS04_RS19400	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BHS04_RS19425	COG0688	phosphatidylethanolamine metabolic process
BHS04_RS19460	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BHS04_RS19470	COG3781	membrane
BHS04_RS19475	COG0745	RESPONSE REGULATOR receiver
BHS04_RS19500	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BHS04_RS19500	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BHS04_RS19520	COG1830	Aldolase
BHS04_RS19540	COG0456	acetyltransferase
BHS04_RS19545	COG0156	8-amino-7-oxononanoate synthase activity
BHS04_RS19570	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BHS04_RS19575	COG0840	transmembrane signaling receptor activity
BHS04_RS19575	COG3290	protein histidine kinase activity
BHS04_RS19585	COG1024	Enoyl-CoA hydratase
BHS04_RS19595	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BHS04_RS19600	COG1960	acyl-CoA dehydrogenase activity
BHS04_RS19610	COG0571	ribonuclease III activity
BHS04_RS19625	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BHS04_RS19630	COG1160	GTP binding
BHS04_RS19675	COG0519	Catalyzes the synthesis of GMP from XMP
BHS04_RS19685	COG0517	IMP dehydrogenase activity
BHS04_RS19685	COG0516	GMP reductase activity
BHS04_RS19690	COG0443	Heat shock 70 kDa protein
BHS04_RS19720	COG0586	Pfam SNARE associated Golgi protein
BHS04_RS19730	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
BHS04_RS19735	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BHS04_RS19750	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BHS04_RS19760	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
BHS04_RS19765	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
BHS04_RS19770	COG0183	Belongs to the thiolase family
BHS04_RS19785	COG1960	acyl-CoA dehydrogenase activity
BHS04_RS19790	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
BHS04_RS19795	COG1960	acyl-CoA dehydrogenase activity
BHS04_RS19805	COG1024	Enoyl-CoA hydratase
BHS04_RS19810	COG1250	3-hydroxyacyl-CoA dehydrogenase
BHS04_RS19825	COG0489	protein tyrosine kinase activity
BHS04_RS19895	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BHS04_RS19930	COG0430	RNA-3'-phosphate cyclase activity
BHS04_RS19945	COG3852	Histidine kinase
BHS04_RS20015	COG2165	general secretion pathway protein
BHS04_RS20040	COG1946	Acyl-CoA thioesterase
BHS04_RS20055	COG1047	Peptidyl-prolyl cis-trans
BHS04_RS20060	COG3359	exonuclease
BHS04_RS20065	COG1111	helicase
BHS04_RS20065	COG1205	dead DEAH box helicase
BHS04_RS20070	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
BHS04_RS20085	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BHS04_RS20100	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BHS04_RS20105	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
BHS04_RS20120	COG4974	Belongs to the 'phage' integrase family
BHS04_RS20130	COG0009	L-threonylcarbamoyladenylate synthase
BHS04_RS20135	COG0475	glutathione-regulated potassium exporter activity
BHS04_RS20135	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BHS04_RS20155	COG0398	Pfam SNARE associated Golgi protein
BHS04_RS20190	COG2205	protein histidine kinase activity
BHS04_RS20195	COG0028	Belongs to the TPP enzyme family
BHS04_RS20200	COG2111	Na H antiporter
BHS04_RS20200	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BHS04_RS20205	COG2111	Na H antiporter
BHS04_RS20210	COG1006	Multisubunit Na H antiporter MnhC subunit
BHS04_RS20215	COG0651	ATP synthesis coupled electron transport
BHS04_RS20220	COG1863	multisubunit Na H antiporter MnhE subunit
BHS04_RS20225	COG2212	antiporter activity
BHS04_RS20230	COG1320	monovalent cation:proton antiporter activity
BHS04_RS20245	COG1845	cytochrome c oxidase, subunit III
BHS04_RS20250	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BHS04_RS20250	COG1845	cytochrome c oxidase, subunit III
BHS04_RS20255	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BHS04_RS20285	COG0437	4 iron, 4 sulfur cluster binding
BHS04_RS20295	COG1301	dicarboxylic acid transport
BHS04_RS20305	COG4191	Histidine kinase
BHS04_RS20305	COG0784	Response regulator, receiver
BHS04_RS20310	COG2814	Major facilitator Superfamily
BHS04_RS20315	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
BHS04_RS20340	COG0860	N-Acetylmuramoyl-L-alanine amidase
BHS04_RS20370	COG0110	maltose O-acetyltransferase activity
BHS04_RS20390	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BHS04_RS20395	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
BHS04_RS20440	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BHS04_RS20450	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BHS04_RS20455	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BHS04_RS20455	COG1116	anion transmembrane transporter activity
BHS04_RS20460	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BHS04_RS20485	COG0067	glutamate synthase
BHS04_RS20485	COG0070	glutamate synthase
BHS04_RS20485	COG0069	glutamate synthase activity
BHS04_RS20495	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BHS04_RS20500	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
BHS04_RS20510	COG4654	Cytochrome c, class I
BHS04_RS20515	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BHS04_RS20545	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BHS04_RS20560	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BHS04_RS20600	COG0585	pseudouridine synthase activity
BHS04_RS20625	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BHS04_RS20635	COG1028	Short-chain dehydrogenase reductase Sdr
BHS04_RS20660	COG0708	Exodeoxyribonuclease III
BHS04_RS20750	COG0488	(ABC) transporter
BHS04_RS20830	COG0667	Aldo Keto reductase
BHS04_RS20910	COG0823	Involved in the tonB-independent uptake of proteins
BHS04_RS20920	COG0205	6-phosphofructokinase activity
BHS04_RS20925	COG0515	serine threonine protein kinase
BHS04_RS20925	COG2815	serine threonine protein kinase
BHS04_RS20965	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BHS04_RS21005	COG0741	lytic transglycosylase activity
BHS04_RS21015	COG1733	regulation of RNA biosynthetic process
BHS04_RS21020	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BHS04_RS21025	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BHS04_RS21030	COG0825	malonyl-CoA metabolic process
BHS04_RS21065	COG2766	serine protein kinase
BHS04_RS21070	COG0443	Heat shock 70 kDa protein
BHS04_RS21075	COG0515	serine threonine protein kinase
BHS04_RS21085	COG0495	leucyl-tRNA aminoacylation
BHS04_RS21100	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BHS04_RS21115	COG0101	tRNA pseudouridine synthase activity
BHS04_RS21150	COG1606	tRNA processing
BHS04_RS21155	COG2046	Belongs to the sulfate adenylyltransferase family
BHS04_RS21155	COG0529	Catalyzes the synthesis of activated sulfate
BHS04_RS21170	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
BHS04_RS21180	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BHS04_RS21190	COG4585	Histidine kinase
BHS04_RS21205	COG1131	(ABC) transporter
BHS04_RS21220	COG3321	synthase
BHS04_RS21220	COG1028	Short-chain dehydrogenase reductase Sdr
BHS04_RS21220	COG0604	alcohol dehydrogenase
BHS04_RS21230	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BHS04_RS21240	COG0513	Belongs to the DEAD box helicase family
BHS04_RS21245	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BHS04_RS21260	COG1408	metallophosphoesterase
BHS04_RS21315	COG1181	Belongs to the D-alanine--D-alanine ligase family
BHS04_RS21330	COG0113	porphobilinogen synthase activity
BHS04_RS21340	COG1131	(ABC) transporter
BHS04_RS21415	COG0625	glutathione transferase activity
BHS04_RS21435	COG0583	DNA-binding transcription factor activity
BHS04_RS21460	COG1028	Short-chain dehydrogenase reductase Sdr
BHS04_RS21490	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BHS04_RS21500	COG4974	Belongs to the 'phage' integrase family
BHS04_RS21510	COG2801	Transposase and inactivated derivatives
BHS04_RS21515	COG0582	viral genome integration into host DNA
BHS04_RS21545	COG0515	serine threonine protein kinase
BHS04_RS21545	COG2815	serine threonine protein kinase
BHS04_RS21575	COG2801	Transposase and inactivated derivatives
BHS04_RS21655	COG0745	RESPONSE REGULATOR receiver
BHS04_RS21665	COG0686	Belongs to the AlaDH PNT family
BHS04_RS21670	COG1595	DNA-templated transcription, initiation
BHS04_RS21680	COG0745	RESPONSE REGULATOR receiver
BHS04_RS21690	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
BHS04_RS21695	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
BHS04_RS21695	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
BHS04_RS21725	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BHS04_RS21735	COG3220	belongs to the UPF0276 family
BHS04_RS21750	COG0745	RESPONSE REGULATOR receiver
BHS04_RS21795	COG0577	efflux transmembrane transporter activity
BHS04_RS21795	COG1136	(ABC) transporter
BHS04_RS21800	COG1136	(ABC) transporter
BHS04_RS21805	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BHS04_RS21820	COG0542	response to heat
BHS04_RS21855	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BHS04_RS21865	COG3876	Protein conserved in bacteria
BHS04_RS21880	COG1193	negative regulation of DNA recombination
BHS04_RS21905	COG2204	response regulator
BHS04_RS21910	COG4191	Histidine kinase
BHS04_RS21920	COG1136	(ABC) transporter
BHS04_RS21925	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BHS04_RS21930	COG0577	efflux transmembrane transporter activity
BHS04_RS21930	COG1136	(ABC) transporter
BHS04_RS21935	COG0693	protein deglycase activity
BHS04_RS21940	COG0745	RESPONSE REGULATOR receiver
BHS04_RS21960	COG1028	Short-chain dehydrogenase reductase Sdr
BHS04_RS21965	COG1408	metallophosphoesterase
BHS04_RS21985	COG0557	exoribonuclease II activity
BHS04_RS21995	COG0303	'Molybdopterin
BHS04_RS22000	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BHS04_RS22000	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BHS04_RS22025	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BHS04_RS22030	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BHS04_RS22045	COG0140	phosphoribosyl-ATP diphosphatase activity
BHS04_RS22045	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BHS04_RS22055	COG0107	imidazoleglycerol-phosphate synthase activity
BHS04_RS22060	COG0131	Imidazoleglycerol-phosphate dehydratase
BHS04_RS22065	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BHS04_RS22070	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
BHS04_RS22075	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BHS04_RS22085	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BHS04_RS22090	COG2022	thiamine diphosphate biosynthetic process
BHS04_RS22090	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BHS04_RS22095	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
BHS04_RS22095	COG2199	diguanylate cyclase activity
BHS04_RS22110	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
BHS04_RS22120	COG0471	metal ion transport
BHS04_RS22130	COG2204	response regulator
BHS04_RS22150	COG4191	Histidine kinase
BHS04_RS22155	COG0745	RESPONSE REGULATOR receiver
BHS04_RS22155	COG4566	intracellular signal transduction
BHS04_RS22160	COG2205	protein histidine kinase activity
BHS04_RS22195	COG3852	Histidine kinase
BHS04_RS22255	COG2204	response regulator
BHS04_RS22260	COG4191	Histidine kinase
BHS04_RS22265	COG1309	transcriptional regulator
BHS04_RS22270	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
BHS04_RS22285	COG3425	synthase
BHS04_RS22290	COG0071	Belongs to the small heat shock protein (HSP20) family
BHS04_RS22355	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BHS04_RS22375	COG1942	4-Oxalocrotonate Tautomerase
BHS04_RS22390	COG0076	glutamate decarboxylase activity
BHS04_RS22455	COG0003	Pfam Anion-transporting ATPase
BHS04_RS22495	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BHS04_RS22505	COG1960	acyl-CoA dehydrogenase activity
BHS04_RS22510	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BHS04_RS22550	COG0737	Belongs to the 5'-nucleotidase family
BHS04_RS22580	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BHS04_RS22590	COG0730	response to heat
BHS04_RS22630	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BHS04_RS22650	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BHS04_RS22680	COG0515	serine threonine protein kinase
BHS04_RS22690	COG2204	response regulator
BHS04_RS22710	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
BHS04_RS22720	COG1228	amidohydrolase
BHS04_RS22725	COG0121	glutamine amidotransferase
BHS04_RS22735	COG0802	atpase or kinase
BHS04_RS22740	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BHS04_RS22740	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
BHS04_RS22745	COG0736	holo-[acyl-carrier-protein] synthase activity
BHS04_RS22750	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
BHS04_RS22755	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BHS04_RS22760	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BHS04_RS22770	COG2353	YceI-like domain
BHS04_RS22775	COG0583	DNA-binding transcription factor activity
BHS04_RS22780	COG1741	Belongs to the pirin family
BHS04_RS22785	COG1741	Belongs to the pirin family
BHS04_RS22790	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BHS04_RS22795	COG0037	tRNA processing
BHS04_RS22835	COG2226	methyltransferase
BHS04_RS22845	COG0515	serine threonine protein kinase
BHS04_RS22845	COG2815	serine threonine protein kinase
BHS04_RS22855	COG0515	serine threonine protein kinase
BHS04_RS22895	COG3246	L-lysine catabolic process to acetate
BHS04_RS22900	COG1607	acyl-coa hydrolase
BHS04_RS22905	COG5012	cobalamin binding
BHS04_RS22915	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
BHS04_RS22920	COG0753	catalase activity
BHS04_RS22930	COG0604	alcohol dehydrogenase
BHS04_RS22940	COG1573	uracil-dna glycosylase
BHS04_RS22950	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BHS04_RS22965	COG0631	protein serine/threonine phosphatase activity
BHS04_RS23015	COG0318	PFAM AMP-dependent synthetase and ligase
BHS04_RS23020	COG1742	UPF0060 membrane protein
BHS04_RS23030	COG0583	DNA-binding transcription factor activity
BHS04_RS23035	COG0702	epimerase
BHS04_RS23065	COG2119	membrane
BHS04_RS23085	COG4464	protein tyrosine phosphatase activity
BHS04_RS23090	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
BHS04_RS23105	COG0010	Belongs to the arginase family
BHS04_RS23115	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BHS04_RS23120	COG2815	serine threonine protein kinase
BHS04_RS23120	COG0515	serine threonine protein kinase
BHS04_RS23125	COG3268	Saccharopine dehydrogenase
BHS04_RS23140	COG0745	RESPONSE REGULATOR receiver
BHS04_RS23175	COG5002	protein histidine kinase activity
BHS04_RS23180	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BHS04_RS23195	COG0739	heme binding
BHS04_RS23200	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
BHS04_RS23205	COG0148	phosphopyruvate hydratase activity
BHS04_RS23220	COG1494	fructose-1,6-bisphosphatase
BHS04_RS23225	COG0824	Thioesterase
BHS04_RS23230	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
BHS04_RS23240	COG0525	valine-tRNA ligase activity
BHS04_RS23255	COG3706	GGDEF domain
BHS04_RS23275	COG0459	protein refolding
BHS04_RS23450	COG1222	aaa ATPase
BHS04_RS23465	COG0667	Aldo Keto reductase
BHS04_RS23470	COG4221	oxidoreductase activity
BHS04_RS23480	COG3119	arylsulfatase activity
BHS04_RS23495	COG3321	synthase
BHS04_RS23495	COG1028	Short-chain dehydrogenase reductase Sdr
BHS04_RS23495	COG0604	alcohol dehydrogenase
BHS04_RS23580	COG1032	radical SAM domain protein
BHS04_RS23610	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BHS04_RS23645	COG0515	serine threonine protein kinase
BHS04_RS23655	COG4771	TonB-dependent receptor
BHS04_RS23670	COG2770	Histidine kinase
BHS04_RS23670	COG2208	phosphoserine phosphatase activity
BHS04_RS23675	COG0750	zinc metalloprotease
BHS04_RS23685	COG0022	dehydrogenase e1 component
BHS04_RS23740	COG1042	CoA-binding domain protein
BHS04_RS23740	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BHS04_RS23740	COG0045	succinate-CoA ligase (ADP-forming) activity
BHS04_RS23765	COG2885	chlorophyll binding
BHS04_RS23785	COG0343	queuine tRNA-ribosyltransferase activity
BHS04_RS23790	COG0488	(ABC) transporter
BHS04_RS23800	COG1295	ribonuclease BN
BHS04_RS23845	COG0477	Major facilitator Superfamily
BHS04_RS23885	COG0463	Glycosyl transferase, family 2
BHS04_RS23895	COG1215	transferase activity, transferring glycosyl groups
BHS04_RS23940	COG0741	lytic transglycosylase activity
BHS04_RS23965	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BHS04_RS24010	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
BHS04_RS24015	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BHS04_RS24035	COG1570	exodeoxyribonuclease VII activity
BHS04_RS24120	COG4608	Belongs to the ABC transporter superfamily
BHS04_RS24125	COG0444	Belongs to the ABC transporter superfamily
BHS04_RS24145	COG0811	peptide transport
BHS04_RS24155	COG1960	acyl-CoA dehydrogenase activity
BHS04_RS24165	COG2030	dehydratase
BHS04_RS24180	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BHS04_RS24190	COG0714	Associated with various cellular activities
BHS04_RS24200	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BHS04_RS24205	COG1193	negative regulation of DNA recombination
BHS04_RS24245	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
BHS04_RS24245	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BHS04_RS24255	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BHS04_RS24260	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BHS04_RS24265	COG1862	Preprotein translocase
BHS04_RS24270	COG0343	queuine tRNA-ribosyltransferase activity
BHS04_RS24280	COG2385	sporulation resulting in formation of a cellular spore
BHS04_RS24300	COG1509	lysine 2,3-aminomutase activity
BHS04_RS24310	COG0515	serine threonine protein kinase
BHS04_RS24420	COG0194	GDP metabolic process
BHS04_RS24425	COG1561	YicC-like family, N-terminal region
BHS04_RS24435	COG2835	tetraacyldisaccharide 4'-kinase activity
BHS04_RS24440	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
BHS04_RS24440	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
BHS04_RS24450	COG1663	tetraacyldisaccharide 4'-kinase activity
BHS04_RS24475	COG1132	(ABC) transporter
BHS04_RS24485	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BHS04_RS24495	COG2095	MarC family integral membrane protein
BHS04_RS24515	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BHS04_RS24520	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BHS04_RS24525	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BHS04_RS24535	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BHS04_RS24540	COG1136	(ABC) transporter
BHS04_RS24550	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BHS04_RS24560	COG1595	DNA-templated transcription, initiation
BHS04_RS24575	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BHS04_RS24575	COG0662	Cupin 2, conserved barrel domain protein
BHS04_RS24580	COG1480	7TM receptor with intracellular HD hydrolase
BHS04_RS24600	COG3956	TIGRFAM MazG family protein
BHS04_RS24605	COG0268	Binds directly to 16S ribosomal RNA
BHS04_RS24620	COG0495	leucyl-tRNA aminoacylation
BHS04_RS24625	COG4771	TonB-dependent receptor
BHS04_RS24635	COG2084	Dehydrogenase
BHS04_RS24645	COG1131	(ABC) transporter
BHS04_RS24650	COG0745	RESPONSE REGULATOR receiver
BHS04_RS24655	COG2201	protein-glutamate methylesterase activity
BHS04_RS24660	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BHS04_RS24675	COG0835	chemotaxis
BHS04_RS24685	COG0643	Histidine kinase
BHS04_RS24685	COG2198	Histidine kinase
BHS04_RS24685	COG0784	Response regulator, receiver
BHS04_RS24685	COG0643	Histidine kinase
BHS04_RS24685	COG2198	Histidine kinase
BHS04_RS24685	COG0784	Response regulator, receiver
BHS04_RS24690	COG0745	RESPONSE REGULATOR receiver
BHS04_RS24700	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BHS04_RS24705	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BHS04_RS24715	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BHS04_RS24715	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BHS04_RS24720	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BHS04_RS24725	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BHS04_RS24730	COG0698	ribose 5-phosphate isomerase
BHS04_RS24735	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BHS04_RS24740	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BHS04_RS24745	COG1028	Short-chain dehydrogenase reductase Sdr
BHS04_RS24750	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BHS04_RS24755	COG0416	fatty acid biosynthetic process
BHS04_RS24760	COG0333	Belongs to the bacterial ribosomal protein bL32 family
BHS04_RS24765	COG1399	metal-binding, possibly nucleic acid-binding protein
BHS04_RS24780	COG0745	RESPONSE REGULATOR receiver
BHS04_RS24785	COG5002	protein histidine kinase activity
BHS04_RS24795	COG2062	phosphohistidine phosphatase, SixA
BHS04_RS24805	COG0730	response to heat
BHS04_RS24815	COG0659	secondary active sulfate transmembrane transporter activity
BHS04_RS24825	COG5002	protein histidine kinase activity
BHS04_RS24830	COG0745	RESPONSE REGULATOR receiver
BHS04_RS24840	COG0573	inorganic phosphate transmembrane transporter activity
BHS04_RS24845	COG0581	inorganic phosphate transmembrane transporter activity
BHS04_RS24850	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BHS04_RS24865	COG0745	RESPONSE REGULATOR receiver
BHS04_RS24870	COG1253	flavin adenine dinucleotide binding
BHS04_RS24885	COG3436	PFAM IS66 Orf2 family protein
BHS04_RS24920	COG2885	chlorophyll binding
BHS04_RS24920	COG3047	cAMP biosynthetic process
BHS04_RS25015	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
BHS04_RS25020	COG4208	sulfate ABC transporter
BHS04_RS25035	COG0542	response to heat
BHS04_RS25055	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BHS04_RS25065	COG1529	Aldehyde oxidase and xanthine dehydrogenase
BHS04_RS25080	COG0542	response to heat
BHS04_RS25095	COG0477	Major facilitator Superfamily
BHS04_RS25105	COG0154	amidase activity
BHS04_RS25115	COG0583	DNA-binding transcription factor activity
BHS04_RS25120	COG0514	ATP-dependent DNA helicase (RecQ)
BHS04_RS25135	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BHS04_RS25210	COG1324	tolerance protein
BHS04_RS25225	COG0527	aspartate kinase activity
BHS04_RS25265	COG1595	DNA-templated transcription, initiation
BHS04_RS25285	COG2223	nitrite transmembrane transporter activity
BHS04_RS25305	COG1758	RNA polymerase activity
BHS04_RS25325	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BHS04_RS25330	COG0459	protein refolding
BHS04_RS25350	COG3829	transcription factor binding
BHS04_RS25360	COG1196	nuclear chromosome segregation
BHS04_RS25365	COG1253	flavin adenine dinucleotide binding
BHS04_RS25375	COG2843	Capsule synthesis protein
BHS04_RS25380	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BHS04_RS25385	COG2890	protein-(glutamine-N5) methyltransferase activity
BHS04_RS25390	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BHS04_RS25425	COG2124	cytochrome p450
BHS04_RS25465	COG2264	protein methyltransferase activity
BHS04_RS25505	COG1231	oxidoreductase activity
BHS04_RS25550	COG1028	Short-chain dehydrogenase reductase Sdr
BHS04_RS25580	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
BHS04_RS25615	COG3220	belongs to the UPF0276 family
BHS04_RS25640	COG3800	Transcriptional regulator
BHS04_RS25640	COG1396	sequence-specific DNA binding
BHS04_RS25655	COG0730	response to heat
BHS04_RS25665	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BHS04_RS25680	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BHS04_RS25680	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
BHS04_RS25685	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
BHS04_RS25695	COG2255	four-way junction helicase activity
BHS04_RS25710	COG0632	four-way junction helicase activity
BHS04_RS25715	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
BHS04_RS25720	COG0217	transcriptional regulatory protein
BHS04_RS25735	COG2204	response regulator
BHS04_RS25750	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BHS04_RS25755	COG0430	RNA-3'-phosphate cyclase activity
BHS04_RS25760	COG1690	Belongs to the RtcB family
BHS04_RS25765	COG4650	regulator
BHS04_RS25790	COG2205	protein histidine kinase activity
BHS04_RS25840	COG3011	Protein conserved in bacteria
BHS04_RS25860	COG1104	cysteine desulfurase activity
BHS04_RS25865	COG0822	iron-sulfur transferase activity
BHS04_RS25870	COG0316	Belongs to the HesB IscA family
BHS04_RS25885	COG0633	Ferredoxin
BHS04_RS25955	COG1304	FMN binding
BHS04_RS25985	COG0501	Belongs to the peptidase M48B family
BHS04_RS26020	COG5002	protein histidine kinase activity
BHS04_RS26025	COG0612	Peptidase, M16
BHS04_RS26050	COG1012	belongs to the aldehyde dehydrogenase family
BHS04_RS26055	COG3284	Transcriptional regulator
BHS04_RS26060	COG2885	chlorophyll binding
BHS04_RS26070	COG0457	Tetratricopeptide repeat
BHS04_RS26070	COG0515	serine threonine protein kinase
BHS04_RS26085	COG2204	response regulator
BHS04_RS26090	COG2819	hydrolase of the alpha beta superfamily
BHS04_RS26105	COG0745	RESPONSE REGULATOR receiver
BHS04_RS26135	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BHS04_RS26185	COG1280	lysine exporter protein (LysE YggA)
BHS04_RS26200	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BHS04_RS26205	COG1435	thymidine kinase activity
BHS04_RS26215	COG2088	sporulation resulting in formation of a cellular spore
BHS04_RS26220	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BHS04_RS26225	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
BHS04_RS26230	COG0193	aminoacyl-tRNA hydrolase activity
BHS04_RS26235	COG0360	Binds together with S18 to 16S ribosomal RNA
BHS04_RS26240	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BHS04_RS26245	COG0359	binds to the 23S rRNA
BHS04_RS26255	COG3275	phosphorelay sensor kinase activity
BHS04_RS26260	COG3279	Response regulator of the LytR AlgR family
BHS04_RS26270	COG0351	phosphomethylpyrimidine kinase
BHS04_RS26270	COG0352	thiamine-phosphate diphosphorylase activity
BHS04_RS26270	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
BHS04_RS26275	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
BHS04_RS26280	COG0352	thiamine-phosphate diphosphorylase activity
BHS04_RS26305	COG0542	response to heat
BHS04_RS26315	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BHS04_RS26325	COG2311	Membrane
BHS04_RS26330	COG2311	Membrane
BHS04_RS26345	COG1733	regulation of RNA biosynthetic process
BHS04_RS26350	COG0702	epimerase
BHS04_RS26365	COG1438	arginine binding
BHS04_RS26370	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BHS04_RS26375	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BHS04_RS26385	COG0165	Argininosuccinate lyase
BHS04_RS26390	COG0137	argininosuccinate synthase activity
BHS04_RS26400	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
BHS04_RS26430	COG0515	serine threonine protein kinase
BHS04_RS26450	COG0789	Transcriptional regulator
BHS04_RS26465	COG5002	protein histidine kinase activity
BHS04_RS26470	COG2204	response regulator
BHS04_RS26475	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BHS04_RS26485	COG3186	Phenylalanine-4-hydroxylase
BHS04_RS26525	COG0183	Belongs to the thiolase family
BHS04_RS26530	COG1024	Enoyl-CoA hydratase
BHS04_RS26530	COG1250	3-hydroxyacyl-CoA dehydrogenase
BHS04_RS26545	COG0254	rRNA binding
BHS04_RS26560	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BHS04_RS26565	COG2201	protein-glutamate methylesterase activity
BHS04_RS26595	COG2885	chlorophyll binding
BHS04_RS26600	COG2204	response regulator
BHS04_RS26615	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
BHS04_RS26620	COG0443	Heat shock 70 kDa protein
BHS04_RS26640	COG2135	peptidase activity
BHS04_RS26655	COG0232	Belongs to the dGTPase family. Type 2 subfamily
BHS04_RS26675	COG1132	(ABC) transporter
BHS04_RS26680	COG0577	efflux transmembrane transporter activity
BHS04_RS26700	COG0641	radical SAM
BHS04_RS26720	COG0515	serine threonine protein kinase
BHS04_RS26720	COG2815	serine threonine protein kinase
BHS04_RS26760	COG5000	phosphorelay sensor kinase activity
BHS04_RS26785	COG0745	RESPONSE REGULATOR receiver
BHS04_RS26810	COG3047	cAMP biosynthetic process
BHS04_RS26810	COG2885	chlorophyll binding
BHS04_RS26825	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
BHS04_RS26825	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BHS04_RS26830	COG0252	asparaginase activity
BHS04_RS26940	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BHS04_RS27030	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BHS04_RS27035	COG0513	Belongs to the DEAD box helicase family
BHS04_RS27040	COG0564	pseudouridine synthase activity
BHS04_RS27060	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
BHS04_RS27075	COG0076	glutamate decarboxylase activity
BHS04_RS27080	COG0531	amino acid
BHS04_RS27090	COG0531	amino acid
BHS04_RS27105	COG2860	membrane
BHS04_RS27120	COG3059	membrane
BHS04_RS27130	COG0251	oxidation-reduction process
BHS04_RS27170	COG0412	Dienelactone hydrolase
BHS04_RS27190	COG2207	Transcriptional regulator
BHS04_RS27210	COG3591	Belongs to the peptidase S1B family
BHS04_RS27210	COG1864	DNA RNA non-specific endonuclease
BHS04_RS27270	COG2815	serine threonine protein kinase
BHS04_RS27270	COG0515	serine threonine protein kinase
BHS04_RS27280	COG2204	response regulator
BHS04_RS27300	COG2375	cellular response to nickel ion
BHS04_RS27300	COG1132	(ABC) transporter
BHS04_RS27305	COG1132	(ABC) transporter
BHS04_RS27385	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BHS04_RS27455	COG2909	trisaccharide binding
BHS04_RS27475	COG1278	Cold shock
BHS04_RS27510	COG1131	(ABC) transporter
BHS04_RS27515	COG0109	protoheme IX farnesyltransferase activity
BHS04_RS27535	COG0443	Heat shock 70 kDa protein
BHS04_RS27540	COG0443	Heat shock 70 kDa protein
BHS04_RS27550	COG0737	Belongs to the 5'-nucleotidase family
BHS04_RS27605	COG0493	'glutamate synthase
BHS04_RS27605	COG0543	2 iron, 2 sulfur cluster binding
BHS04_RS27615	COG2062	phosphohistidine phosphatase, SixA
BHS04_RS27630	COG0233	cytoplasmic translational termination
BHS04_RS27635	COG0528	UMP kinase activity
BHS04_RS27640	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BHS04_RS27645	COG0052	Belongs to the universal ribosomal protein uS2 family
BHS04_RS27650	COG0653	protein targeting
BHS04_RS27655	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
BHS04_RS27665	COG0739	heme binding
BHS04_RS27670	COG0631	protein serine/threonine phosphatase activity
BHS04_RS27675	COG0497	DNA recombination
BHS04_RS27680	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BHS04_RS27685	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BHS04_RS27710	COG1309	transcriptional regulator
BHS04_RS27715	COG2814	Major facilitator Superfamily
BHS04_RS27720	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BHS04_RS27730	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BHS04_RS27745	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BHS04_RS27765	COG0463	Glycosyl transferase, family 2
BHS04_RS27770	COG3394	polysaccharide catabolic process
BHS04_RS27785	COG1250	3-hydroxyacyl-CoA dehydrogenase
BHS04_RS27785	COG1024	Enoyl-CoA hydratase
BHS04_RS27790	COG0183	Belongs to the thiolase family
BHS04_RS27795	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
BHS04_RS27800	COG1874	Beta-galactosidase
BHS04_RS27800	COG0366	Alpha amylase catalytic
BHS04_RS27815	COG3842	ATPase activity
BHS04_RS27820	COG1175	transmembrane transport
BHS04_RS27945	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BHS04_RS27980	COG2267	carboxylic ester hydrolase activity
BHS04_RS27985	COG5640	endopeptidase activity
BHS04_RS28015	COG2755	lipolytic protein G-D-S-L family
BHS04_RS28015	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
BHS04_RS28135	COG1505	serine-type exopeptidase activity
BHS04_RS28150	COG0429	hydrolase of the alpha beta-hydrolase fold
BHS04_RS28200	COG1733	regulation of RNA biosynthetic process
BHS04_RS28245	COG2321	neutral zinc metallopeptidase
BHS04_RS28250	COG0612	Peptidase, M16
BHS04_RS28260	COG1652	LysM domain
BHS04_RS28275	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
BHS04_RS28280	COG3973	AAA domain
BHS04_RS28285	COG0784	Response regulator, receiver
BHS04_RS28285	COG2205	protein histidine kinase activity
BHS04_RS28315	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
BHS04_RS28330	COG0583	DNA-binding transcription factor activity
BHS04_RS28335	COG2319	Wd-40 repeat
BHS04_RS28335	COG4249	Peptidase C14 caspase catalytic subunit p20
BHS04_RS28380	COG1126	abc transporter atp-binding protein
BHS04_RS28385	COG0765	amino acid transport
BHS04_RS28395	COG0745	RESPONSE REGULATOR receiver
BHS04_RS28400	COG1595	DNA-templated transcription, initiation
BHS04_RS28420	COG1032	radical SAM domain protein
BHS04_RS28450	COG0564	pseudouridine synthase activity
BHS04_RS28500	COG5380	lipid catabolic process
BHS04_RS28505	COG1902	pentaerythritol trinitrate reductase activity
BHS04_RS28530	COG1671	Belongs to the UPF0178 family
BHS04_RS28545	COG0588	phosphoglycerate mutase activity
BHS04_RS28560	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BHS04_RS28580	COG3278	Belongs to the heme-copper respiratory oxidase family
BHS04_RS28600	COG1309	transcriptional regulator
BHS04_RS28610	COG1309	transcriptional regulator
BHS04_RS28620	COG1024	Enoyl-CoA hydratase
BHS04_RS28630	COG0653	protein targeting
BHS04_RS28635	COG0673	inositol 2-dehydrogenase activity
BHS04_RS28660	COG0437	4 iron, 4 sulfur cluster binding
BHS04_RS28685	COG1858	cytochrome C peroxidase
BHS04_RS28700	COG3030	protein affecting phage T7 exclusion by the F plasmid
BHS04_RS28710	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BHS04_RS28720	COG1929	Belongs to the glycerate kinase type-1 family
BHS04_RS28745	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
BHS04_RS28765	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
BHS04_RS28830	COG0745	RESPONSE REGULATOR receiver
BHS04_RS28840	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
BHS04_RS28845	COG0439	Biotin carboxylase
BHS04_RS28855	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BHS04_RS28870	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BHS04_RS28880	COG1181	Belongs to the D-alanine--D-alanine ligase family
BHS04_RS28885	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BHS04_RS28890	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BHS04_RS28895	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BHS04_RS28905	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BHS04_RS28910	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BHS04_RS28915	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BHS04_RS28920	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BHS04_RS28930	COG3116	cell division
BHS04_RS28935	COG0275	rRNA processing
BHS04_RS28945	COG2001	Belongs to the MraZ family
BHS04_RS28955	COG1960	acyl-CoA dehydrogenase activity
BHS04_RS28960	COG0640	Transcriptional regulator
BHS04_RS28975	COG0515	serine threonine protein kinase
BHS04_RS29030	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BHS04_RS29030	COG0519	Catalyzes the synthesis of GMP from XMP
BHS04_RS29045	COG0628	permease
BHS04_RS29055	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BHS04_RS29060	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BHS04_RS29065	COG1254	Belongs to the acylphosphatase family
BHS04_RS29080	COG1295	ribonuclease BN
BHS04_RS29095	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BHS04_RS29105	COG1987	bacterial-type flagellum assembly
BHS04_RS29130	COG4669	(LipO)protein
BHS04_RS29150	COG0745	RESPONSE REGULATOR receiver
BHS04_RS29180	COG2304	oxidoreductase activity
BHS04_RS29200	COG0714	Associated with various cellular activities
BHS04_RS29225	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BHS04_RS29235	COG2204	response regulator
BHS04_RS29240	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
BHS04_RS29255	COG4968	Prepilin-type N-terminal cleavage methylation domain
BHS04_RS29285	COG2204	response regulator
BHS04_RS29320	COG0668	transmembrane transport
BHS04_RS29330	COG0737	Belongs to the 5'-nucleotidase family
BHS04_RS29335	COG1388	LysM domain
BHS04_RS29335	COG0741	lytic transglycosylase activity
BHS04_RS29365	COG0515	serine threonine protein kinase
BHS04_RS29380	COG1136	(ABC) transporter
BHS04_RS29380	COG0577	efflux transmembrane transporter activity
BHS04_RS29410	COG0402	S-adenosylhomocysteine deaminase activity
BHS04_RS29440	COG1744	ABC transporter substrate-binding protein PnrA-like
BHS04_RS29445	COG3845	ABC transporter
BHS04_RS29450	COG4603	Belongs to the binding-protein-dependent transport system permease family
BHS04_RS29455	COG1079	Belongs to the binding-protein-dependent transport system permease family
BHS04_RS29460	COG4191	Histidine kinase
BHS04_RS29470	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BHS04_RS29480	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
BHS04_RS29485	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
BHS04_RS29535	COG4941	Belongs to the sigma-70 factor family
BHS04_RS29555	COG0552	protein localization to endoplasmic reticulum
BHS04_RS29580	COG1215	transferase activity, transferring glycosyl groups
BHS04_RS29585	COG1181	Belongs to the D-alanine--D-alanine ligase family
BHS04_RS29600	COG0793	Belongs to the peptidase S41A family
BHS04_RS29605	COG0596	Alpha beta hydrolase
BHS04_RS29605	COG0508	dehydrogenase complex catalyzes the overall conversion of
BHS04_RS29615	COG2177	Part of the ABC transporter FtsEX involved in
BHS04_RS29620	COG2884	Cell division ATP-binding protein ftsE
BHS04_RS29635	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
BHS04_RS29645	COG0811	peptide transport
BHS04_RS29660	COG0823	Involved in the tonB-independent uptake of proteins
BHS04_RS29675	COG2223	nitrite transmembrane transporter activity
BHS04_RS29690	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BHS04_RS29700	COG3267	Type II secretory pathway component ExeA
BHS04_RS29700	COG3409	Peptidoglycan-binding domain 1 protein
BHS04_RS29710	COG0439	Biotin carboxylase
BHS04_RS29715	COG0511	ligase activity, forming carbon-carbon bonds
BHS04_RS29720	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BHS04_RS29760	COG2204	response regulator
BHS04_RS29765	COG3852	Histidine kinase
BHS04_RS29770	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
BHS04_RS29780	COG1131	(ABC) transporter
BHS04_RS29790	COG4968	Prepilin-type N-terminal cleavage methylation domain
BHS04_RS29800	COG3852	Histidine kinase
BHS04_RS29805	COG1459	type II secretion system
BHS04_RS29815	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BHS04_RS29825	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BHS04_RS29850	COG1199	ATP-dependent helicase activity
BHS04_RS29890	COG3209	COG3209 Rhs family protein
BHS04_RS29900	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BHS04_RS29915	COG0443	Heat shock 70 kDa protein
BHS04_RS29925	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
BHS04_RS29935	COG0793	Belongs to the peptidase S41A family
BHS04_RS29945	COG0584	glycerophosphoryl diester phosphodiesterase
BHS04_RS29950	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BHS04_RS29970	COG1192	Involved in chromosome partitioning
BHS04_RS29985	COG0003	Pfam Anion-transporting ATPase
BHS04_RS30010	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BHS04_RS30025	COG2766	serine protein kinase
BHS04_RS30030	COG2718	Belongs to the UPF0229 family
BHS04_RS30035	COG2719	SpoVR family
BHS04_RS30040	COG0739	heme binding
BHS04_RS30050	COG0058	SHG alpha-glucan phosphorylase activity
BHS04_RS30070	COG0339	signal peptide processing
BHS04_RS30080	COG1028	Short-chain dehydrogenase reductase Sdr
BHS04_RS30085	COG0826	peptidase U32
BHS04_RS30090	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BHS04_RS30095	COG1024	Enoyl-CoA hydratase
BHS04_RS30150	COG2204	response regulator
BHS04_RS30165	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BHS04_RS30175	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BHS04_RS30180	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BHS04_RS30185	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BHS04_RS30185	COG3453	Protein conserved in bacteria
BHS04_RS30195	COG2032	superoxide dismutase activity
BHS04_RS30250	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BHS04_RS30255	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BHS04_RS30270	COG2353	YceI-like domain
BHS04_RS30275	COG3384	dioxygenase
BHS04_RS30300	COG0183	Belongs to the thiolase family
BHS04_RS30335	COG3189	MarR family transcriptional regulator
BHS04_RS30350	COG4266	Belongs to the allantoicase family
BHS04_RS30355	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BHS04_RS30360	COG2072	flavoprotein involved in K transport
BHS04_RS30365	COG1012	belongs to the aldehyde dehydrogenase family
BHS04_RS30380	COG1960	acyl-CoA dehydrogenase activity
BHS04_RS30385	COG0300	oxidoreductase activity
BHS04_RS30400	COG2169	Transcriptional regulator
BHS04_RS30400	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BHS04_RS30410	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BHS04_RS30420	COG0805	protein transport
BHS04_RS30420	COG0805	protein transport
BHS04_RS30425	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BHS04_RS30435	COG0840	transmembrane signaling receptor activity
BHS04_RS30445	COG0300	oxidoreductase activity
BHS04_RS30450	COG0284	orotidine-5'-phosphate decarboxylase activity
BHS04_RS30460	COG0564	pseudouridine synthase activity
BHS04_RS30475	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
BHS04_RS30475	COG1793	dna ligase
BHS04_RS30500	COG2086	electron transfer activity
BHS04_RS30505	COG1960	acyl-CoA dehydrogenase activity
BHS04_RS30510	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BHS04_RS30515	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
BHS04_RS30515	COG0517	IMP dehydrogenase activity
BHS04_RS30530	COG0179	Fumarylacetoacetate (FAA) hydrolase
BHS04_RS30535	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BHS04_RS30540	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BHS04_RS30565	COG4783	chaperone-mediated protein folding
BHS04_RS30570	COG1295	ribonuclease BN
BHS04_RS30575	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
BHS04_RS30600	COG0697	spore germination
BHS04_RS30610	COG2096	Adenosyltransferase
BHS04_RS30615	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
BHS04_RS30620	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BHS04_RS30655	COG1078	dGTPase activity
BHS04_RS30660	COG1181	Belongs to the D-alanine--D-alanine ligase family
BHS04_RS30675	COG1331	Highly conserved protein containing a thioredoxin domain
BHS04_RS30685	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BHS04_RS30765	COG0508	dehydrogenase complex catalyzes the overall conversion of
BHS04_RS30765	COG0596	Alpha beta hydrolase
BHS04_RS30775	COG0515	serine threonine protein kinase
BHS04_RS30795	COG0037	tRNA processing
BHS04_RS30805	COG0308	aminopeptidase N
BHS04_RS30835	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
BHS04_RS30845	COG2205	protein histidine kinase activity
BHS04_RS30855	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
BHS04_RS30860	COG0251	oxidation-reduction process
BHS04_RS30875	COG3850	Histidine kinase
BHS04_RS30875	COG5002	protein histidine kinase activity
BHS04_RS30900	COG4607	ABC-type enterochelin transport system periplasmic component
BHS04_RS30915	COG1131	(ABC) transporter
BHS04_RS30920	COG2264	protein methyltransferase activity
BHS04_RS30935	COG4377	Putative membrane peptidase family (DUF2324)
BHS04_RS30955	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BHS04_RS30970	COG4191	Histidine kinase
BHS04_RS30975	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BHS04_RS30990	COG0564	pseudouridine synthase activity
BHS04_RS31025	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
BHS04_RS31035	COG0840	transmembrane signaling receptor activity
BHS04_RS31040	COG2201	protein-glutamate methylesterase activity
BHS04_RS31065	COG0784	Response regulator, receiver
BHS04_RS31065	COG2205	protein histidine kinase activity
BHS04_RS31065	COG2198	Histidine kinase
BHS04_RS31070	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BHS04_RS31080	COG0508	dehydrogenase complex catalyzes the overall conversion of
BHS04_RS31085	COG1278	Cold shock
BHS04_RS31105	COG4935	Belongs to the peptidase S8 family
BHS04_RS31105	COG1404	Belongs to the peptidase S8 family
BHS04_RS31110	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BHS04_RS31115	COG2815	serine threonine protein kinase
BHS04_RS31115	COG0515	serine threonine protein kinase
BHS04_RS31120	COG4771	TonB-dependent receptor
BHS04_RS31135	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
BHS04_RS31140	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BHS04_RS31155	COG0326	Molecular chaperone. Has ATPase activity
BHS04_RS31165	COG2205	protein histidine kinase activity
BHS04_RS31170	COG2080	2 iron, 2 sulfur cluster binding
BHS04_RS31175	COG1529	Aldehyde oxidase and xanthine dehydrogenase
BHS04_RS31175	COG2010	Cytochrome c
BHS04_RS31180	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
BHS04_RS31210	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
BHS04_RS31215	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BHS04_RS31220	COG0134	indole-3-glycerol-phosphate synthase activity
BHS04_RS31225	COG0135	phosphoribosylanthranilate isomerase activity
BHS04_RS31230	COG0133	tryptophan synthase activity
BHS04_RS31235	COG0159	tryptophan synthase activity
BHS04_RS31255	COG0406	alpha-ribazole phosphatase activity
BHS04_RS31275	COG1793	dna ligase
BHS04_RS31275	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
BHS04_RS31280	COG1201	RNA secondary structure unwinding
BHS04_RS31300	COG0437	4 iron, 4 sulfur cluster binding
BHS04_RS31335	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BHS04_RS31380	COG0429	hydrolase of the alpha beta-hydrolase fold
BHS04_RS31400	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BHS04_RS31420	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
BHS04_RS31445	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
BHS04_RS31460	COG0546	phosphoglycolate phosphatase activity
BHS04_RS31485	COG2205	protein histidine kinase activity
BHS04_RS31520	COG0322	excinuclease ABC activity
BHS04_RS31580	COG2188	Transcriptional regulator
BHS04_RS31635	COG1366	Belongs to the anti-sigma-factor antagonist family
BHS04_RS31705	COG0544	peptidyl-prolyl cis-trans isomerase activity
BHS04_RS31715	COG2824	Alkylphosphonate utilization operon protein PhnA
BHS04_RS31735	COG2197	response regulator
BHS04_RS31765	COG1090	epimerase
BHS04_RS31770	COG1764	response to oxidative stress
BHS04_RS31820	COG0753	catalase activity
BHS04_RS31845	COG1404	Belongs to the peptidase S8 family
BHS04_RS31900	COG3436	PFAM IS66 Orf2 family protein
BHS04_RS31915	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BHS04_RS31920	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
BHS04_RS31925	COG1231	oxidoreductase activity
BHS04_RS31965	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BHS04_RS31985	COG0004	ammonium transporteR
BHS04_RS31995	COG0515	serine threonine protein kinase
BHS04_RS32020	COG1760	l-serine dehydratase
BHS04_RS32030	COG0753	catalase activity
BHS04_RS32030	COG0693	protein deglycase activity
BHS04_RS32055	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
BHS04_RS32065	COG0438	transferase activity, transferring glycosyl groups
BHS04_RS32080	COG3938	Belongs to the proline racemase family
BHS04_RS32085	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BHS04_RS32100	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BHS04_RS32110	COG3291	Pkd domain containing protein
BHS04_RS32140	COG0300	oxidoreductase activity
BHS04_RS32180	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BHS04_RS32190	COG5002	protein histidine kinase activity
BHS04_RS32195	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
BHS04_RS32225	COG0739	heme binding
BHS04_RS32225	COG0741	lytic transglycosylase activity
BHS04_RS32225	COG1196	nuclear chromosome segregation
BHS04_RS32265	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
BHS04_RS32295	COG2885	chlorophyll binding
BHS04_RS32315	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BHS04_RS32320	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BHS04_RS32330	COG1309	transcriptional regulator
BHS04_RS32395	COG1509	lysine 2,3-aminomutase activity
BHS04_RS32410	COG3338	carbonate dehydratase activity
BHS04_RS32450	COG3409	Peptidoglycan-binding domain 1 protein
BHS04_RS32450	COG0860	N-Acetylmuramoyl-L-alanine amidase
BHS04_RS32485	COG1028	Short-chain dehydrogenase reductase Sdr
BHS04_RS32490	COG0640	Transcriptional regulator
BHS04_RS32545	COG2342	PFAM TM1410 hypothetical-related protein
BHS04_RS32595	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BHS04_RS32600	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
BHS04_RS32605	COG0469	pyruvate kinase activity
BHS04_RS32635	COG0517	IMP dehydrogenase activity
BHS04_RS32635	COG1994	Peptidase M50
BHS04_RS32660	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BHS04_RS32670	COG0515	serine threonine protein kinase
BHS04_RS32680	COG3394	polysaccharide catabolic process
BHS04_RS32685	COG2205	protein histidine kinase activity
BHS04_RS32690	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BHS04_RS32695	COG0515	serine threonine protein kinase
BHS04_RS32695	COG2815	serine threonine protein kinase
BHS04_RS32705	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BHS04_RS32730	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
BHS04_RS32735	COG1028	Short-chain dehydrogenase reductase Sdr
BHS04_RS32790	COG0473	3-isopropylmalate dehydrogenase activity
BHS04_RS32805	COG0023	Translation Initiation Factor
BHS04_RS32810	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BHS04_RS32820	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BHS04_RS32830	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
BHS04_RS32850	COG0625	glutathione transferase activity
BHS04_RS32885	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BHS04_RS32890	COG0277	FAD linked oxidase domain protein
BHS04_RS32955	COG0741	lytic transglycosylase activity
BHS04_RS32960	COG0363	glucosamine-6-phosphate deaminase activity
BHS04_RS32975	COG0318	PFAM AMP-dependent synthetase and ligase
BHS04_RS32990	COG1408	metallophosphoesterase
BHS04_RS32995	COG0235	Class ii aldolase
BHS04_RS33000	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
BHS04_RS33005	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
BHS04_RS33045	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BHS04_RS33050	COG1012	belongs to the aldehyde dehydrogenase family
BHS04_RS33055	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
BHS04_RS33060	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
BHS04_RS33065	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
BHS04_RS33105	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BHS04_RS33110	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BHS04_RS33120	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BHS04_RS33125	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BHS04_RS33130	COG1028	Short-chain dehydrogenase reductase Sdr
BHS04_RS33135	COG1028	Short-chain dehydrogenase reductase Sdr
BHS04_RS33140	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BHS04_RS33145	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BHS04_RS33150	COG1136	(ABC) transporter
BHS04_RS33150	COG0577	efflux transmembrane transporter activity
BHS04_RS33210	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
BHS04_RS33215	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
BHS04_RS33255	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BHS04_RS33260	COG2204	response regulator
BHS04_RS33270	COG2815	serine threonine protein kinase
BHS04_RS33270	COG0515	serine threonine protein kinase
BHS04_RS33280	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BHS04_RS33285	COG1960	acyl-CoA dehydrogenase activity
BHS04_RS33300	COG4783	chaperone-mediated protein folding
BHS04_RS33320	COG0740	serine-type endopeptidase activity
BHS04_RS33325	COG0114	fumarate hydratase activity
BHS04_RS33335	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
BHS04_RS33340	COG2224	Isocitrate lyase
BHS04_RS33420	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BHS04_RS33435	COG2094	Belongs to the DNA glycosylase MPG family
BHS04_RS33440	COG1640	4-alpha-glucanotransferase
BHS04_RS33470	COG0583	DNA-binding transcription factor activity
BHS04_RS33500	COG1131	(ABC) transporter
BHS04_RS33510	COG0714	Associated with various cellular activities
BHS04_RS33530	COG0667	Aldo Keto reductase
BHS04_RS33610	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
BHS04_RS33615	COG1940	carbohydrate kinase activity
BHS04_RS33650	COG3795	YCII-related domain
BHS04_RS33670	COG1968	undecaprenyl-diphosphatase activity
BHS04_RS33680	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
BHS04_RS33685	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BHS04_RS33710	COG1285	pathogenesis
BHS04_RS33715	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BHS04_RS33720	COG0523	cobalamin synthesis protein
BHS04_RS33725	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BHS04_RS33735	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BHS04_RS33745	COG3716	PTS system mannose fructose sorbose family IID component
BHS04_RS33755	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BHS04_RS33760	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BHS04_RS33760	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
BHS04_RS33765	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BHS04_RS33810	COG4771	TonB-dependent receptor
BHS04_RS33830	COG0747	negative chemotaxis
BHS04_RS33835	COG0601	transmembrane transport
BHS04_RS33840	COG0444	Belongs to the ABC transporter superfamily
BHS04_RS33900	COG1660	Displays ATPase and GTPase activities
BHS04_RS33905	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
BHS04_RS33910	COG0537	adenosine 5'-monophosphoramidase activity
BHS04_RS33925	COG1120	ATPase activity
BHS04_RS33930	COG0515	serine threonine protein kinase
BHS04_RS33940	COG0723	plastoquinol--plastocyanin reductase activity
BHS04_RS33940	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BHS04_RS33955	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BHS04_RS33970	COG4206	TonB-dependent receptor
BHS04_RS34000	COG2205	protein histidine kinase activity
BHS04_RS34000	COG0784	Response regulator, receiver
BHS04_RS34060	COG1506	peptidase
BHS04_RS34060	COG0823	Involved in the tonB-independent uptake of proteins
BHS04_RS34065	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
BHS04_RS34075	COG0443	Heat shock 70 kDa protein
BHS04_RS34085	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BHS04_RS34090	COG1024	Enoyl-CoA hydratase
BHS04_RS34100	COG0714	Associated with various cellular activities
BHS04_RS34135	COG0513	Belongs to the DEAD box helicase family
BHS04_RS34145	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
BHS04_RS34150	COG0745	RESPONSE REGULATOR receiver
BHS04_RS34155	COG1472	Belongs to the glycosyl hydrolase 3 family
BHS04_RS34165	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BHS04_RS34180	COG0745	RESPONSE REGULATOR receiver
BHS04_RS34195	COG0546	phosphoglycolate phosphatase activity
BHS04_RS34195	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
BHS04_RS34200	COG0277	FAD linked oxidase domain protein
BHS04_RS34225	COG0318	PFAM AMP-dependent synthetase and ligase
BHS04_RS34230	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BHS04_RS34235	COG1755	Isoprenylcysteine carboxyl methyltransferase
BHS04_RS34260	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
BHS04_RS34265	COG4149	molybdate abc transporter
BHS04_RS34270	COG0725	ABC transporter, periplasmic molybdate-binding protein
BHS04_RS34275	COG1846	Transcriptional regulator
BHS04_RS34280	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BHS04_RS34285	COG1434	Gram-negative-bacterium-type cell wall biogenesis
BHS04_RS34330	COG0442	prolyl-tRNA aminoacylation
BHS04_RS34335	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
BHS04_RS34350	COG4106	trans-aconitate 2-methyltransferase activity
BHS04_RS34385	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
BHS04_RS34410	COG0443	Heat shock 70 kDa protein
BHS04_RS34415	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BHS04_RS34460	COG3436	PFAM IS66 Orf2 family protein
BHS04_RS34525	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
BHS04_RS34530	COG1691	(AIR) carboxylase
BHS04_RS34540	COG2198	Histidine kinase
BHS04_RS34540	COG0643	Histidine kinase
BHS04_RS34545	COG2201	protein-glutamate methylesterase activity
BHS04_RS34550	COG0835	chemotaxis
BHS04_RS34565	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
BHS04_RS34590	COG5002	protein histidine kinase activity
BHS04_RS34590	COG2205	protein histidine kinase activity
BHS04_RS34590	COG0784	Response regulator, receiver
BHS04_RS34595	COG1100	Small GTP-binding protein
BHS04_RS34600	COG0456	acetyltransferase
BHS04_RS34620	COG2137	regulation of response to DNA damage stimulus
BHS04_RS34660	COG0024	Methionine aminopeptidase
BHS04_RS34670	COG4206	TonB-dependent receptor
BHS04_RS34675	COG1199	ATP-dependent helicase activity
BHS04_RS34700	COG0546	phosphoglycolate phosphatase activity
BHS04_RS34710	COG1597	lipid kinase activity
BHS04_RS34720	COG1420	regulation of RNA biosynthetic process
BHS04_RS34725	COG0697	spore germination
BHS04_RS34765	COG5002	protein histidine kinase activity
BHS04_RS34765	COG0784	Response regulator, receiver
BHS04_RS34765	COG2205	protein histidine kinase activity
BHS04_RS34820	COG2133	pyrroloquinoline quinone binding
BHS04_RS34825	COG1028	Short-chain dehydrogenase reductase Sdr
BHS04_RS34830	COG0583	DNA-binding transcription factor activity
BHS04_RS34905	COG0408	coproporphyrinogen oxidase activity
BHS04_RS34920	COG2267	carboxylic ester hydrolase activity
BHS04_RS34930	COG0577	efflux transmembrane transporter activity
BHS04_RS34955	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BHS04_RS34965	COG2154	pterin-4-alpha-carbinolamine dehydratase
BHS04_RS34985	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BHS04_RS34995	COG2171	N-acyltransferase activity
BHS04_RS35010	COG0076	glutamate decarboxylase activity
BHS04_RS35020	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BHS04_RS35020	COG4651	solute:proton antiporter activity
BHS04_RS35040	COG1077	Cell shape determining protein MreB Mrl
BHS04_RS35060	COG0583	DNA-binding transcription factor activity
BHS04_RS35065	COG2155	Conserved Protein
BHS04_RS35075	COG3781	membrane
BHS04_RS35125	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BHS04_RS35125	COG0574	Belongs to the PEP-utilizing enzyme family
BHS04_RS35130	COG1063	alcohol dehydrogenase
BHS04_RS35140	COG0534	Mate efflux family protein
BHS04_RS35145	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BHS04_RS35185	COG3011	Protein conserved in bacteria
BHS04_RS35190	COG1505	serine-type exopeptidase activity
BHS04_RS35205	COG3594	Acyltransferase
BHS04_RS35235	COG0308	aminopeptidase N
BHS04_RS35255	COG1668	transmembrane transport
BHS04_RS35260	COG4555	ABC transporter
BHS04_RS35275	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
BHS04_RS35300	COG3568	Endonuclease Exonuclease Phosphatase
BHS04_RS35300	COG1555	photosystem II stabilization
BHS04_RS35330	COG0477	Major facilitator Superfamily
BHS04_RS35360	COG5002	protein histidine kinase activity
BHS04_RS35365	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BHS04_RS35380	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BHS04_RS35380	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BHS04_RS35425	COG0546	phosphoglycolate phosphatase activity
BHS04_RS35445	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BHS04_RS35450	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BHS04_RS35450	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BHS04_RS35470	COG0720	synthase
BHS04_RS35475	COG4221	oxidoreductase activity
BHS04_RS35510	COG1028	Short-chain dehydrogenase reductase Sdr
BHS04_RS35520	COG2226	methyltransferase
BHS04_RS35525	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BHS04_RS35575	COG1160	GTP binding
BHS04_RS35590	COG3047	cAMP biosynthetic process
BHS04_RS35590	COG2885	chlorophyll binding
BHS04_RS35640	COG0166	Belongs to the GPI family
BHS04_RS35655	COG4771	TonB-dependent receptor
BHS04_RS35665	COG1271	oxidase subunit
BHS04_RS35690	COG1959	2 iron, 2 sulfur cluster binding
BHS04_RS35700	COG2346	COG2346, Truncated hemoglobins
BHS04_RS35705	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BHS04_RS35715	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BHS04_RS35725	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BHS04_RS35730	COG0784	Response regulator, receiver
BHS04_RS35730	COG0835	chemotaxis
BHS04_RS35735	COG2949	membrane
BHS04_RS35750	COG3118	belongs to the thioredoxin family
BHS04_RS35785	COG0840	transmembrane signaling receptor activity
BHS04_RS35820	COG0515	serine threonine protein kinase
BHS04_RS35870	COG0835	chemotaxis
BHS04_RS35885	COG0840	transmembrane signaling receptor activity
BHS04_RS35895	COG2201	protein-glutamate methylesterase activity
BHS04_RS35900	COG5002	protein histidine kinase activity
BHS04_RS35910	COG5002	protein histidine kinase activity
BHS04_RS35915	COG0745	RESPONSE REGULATOR receiver
BHS04_RS35930	COG2201	protein-glutamate methylesterase activity
BHS04_RS35950	COG0835	chemotaxis
BHS04_RS35955	COG2198	Histidine kinase
BHS04_RS35955	COG0643	Histidine kinase
BHS04_RS35970	COG5002	protein histidine kinase activity
BHS04_RS35980	COG0745	RESPONSE REGULATOR receiver
BHS04_RS35995	COG0784	Response regulator, receiver
BHS04_RS35995	COG2205	protein histidine kinase activity
BHS04_RS35995	COG5002	protein histidine kinase activity
BHS04_RS36000	COG1408	metallophosphoesterase
BHS04_RS36040	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
BHS04_RS36050	COG2226	methyltransferase
BHS04_RS36055	COG0789	Transcriptional regulator
BHS04_RS36070	COG2010	Cytochrome c
BHS04_RS36080	COG1012	belongs to the aldehyde dehydrogenase family
BHS04_RS36090	COG0183	Belongs to the thiolase family
BHS04_RS36095	COG1960	acyl-CoA dehydrogenase activity
BHS04_RS36100	COG1960	acyl-CoA dehydrogenase activity
BHS04_RS36120	COG1024	Enoyl-CoA hydratase
BHS04_RS36145	COG5002	protein histidine kinase activity
BHS04_RS36150	COG0745	RESPONSE REGULATOR receiver
BHS04_RS36185	COG5002	protein histidine kinase activity
BHS04_RS36195	COG0745	RESPONSE REGULATOR receiver
BHS04_RS36225	COG1518	maintenance of DNA repeat elements
BHS04_RS36260	COG0534	Mate efflux family protein
BHS04_RS36275	COG0443	Heat shock 70 kDa protein
BHS04_RS36280	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BHS04_RS36300	COG2205	protein histidine kinase activity
BHS04_RS36300	COG0784	Response regulator, receiver
BHS04_RS36320	COG2204	response regulator
BHS04_RS36330	COG0746	molybdenum cofactor guanylyltransferase activity
BHS04_RS36335	COG0435	Glutathione S-transferase
BHS04_RS36360	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BHS04_RS36360	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BHS04_RS36370	COG0667	Aldo Keto reductase
BHS04_RS36450	COG2270	Major facilitator Superfamily
BHS04_RS36465	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BHS04_RS36470	COG1472	Belongs to the glycosyl hydrolase 3 family
BHS04_RS36480	COG0217	transcriptional regulatory protein
BHS04_RS36485	COG2879	small protein
BHS04_RS36490	COG1966	Carbon starvation protein
BHS04_RS36510	COG1733	regulation of RNA biosynthetic process
BHS04_RS36520	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BHS04_RS36540	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BHS04_RS36580	COG2226	methyltransferase
BHS04_RS36590	COG0515	serine threonine protein kinase
BHS04_RS36590	COG2815	serine threonine protein kinase
BHS04_RS36630	COG0386	Belongs to the glutathione peroxidase family
BHS04_RS36650	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
BHS04_RS36720	COG0412	Dienelactone hydrolase
BHS04_RS36725	COG0545	Peptidyl-prolyl cis-trans isomerase
BHS04_RS36750	COG4149	molybdate abc transporter
BHS04_RS36770	COG0534	Mate efflux family protein
BHS04_RS36790	COG2205	protein histidine kinase activity
BHS04_RS36855	COG1546	Belongs to the CinA family
BHS04_RS36855	COG1058	Belongs to the CinA family
BHS04_RS36860	COG0768	penicillin binding
BHS04_RS36875	COG3852	Histidine kinase
BHS04_RS36885	COG0577	efflux transmembrane transporter activity
BHS04_RS36885	COG1136	(ABC) transporter
BHS04_RS36890	COG1136	(ABC) transporter
BHS04_RS36895	COG1136	(ABC) transporter
BHS04_RS36895	COG0577	efflux transmembrane transporter activity
BHS04_RS36905	COG0318	PFAM AMP-dependent synthetase and ligase
BHS04_RS36910	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
BHS04_RS36945	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BHS04_RS36950	COG1024	Enoyl-CoA hydratase
BHS04_RS36955	COG0308	aminopeptidase N
BHS04_RS36960	COG1560	Kdo2-lipid A biosynthetic process
BHS04_RS36975	COG2815	serine threonine protein kinase
BHS04_RS36975	COG0515	serine threonine protein kinase
BHS04_RS36980	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BHS04_RS36990	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BHS04_RS37020	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BHS04_RS37040	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BHS04_RS37050	COG0745	RESPONSE REGULATOR receiver
BHS04_RS37060	COG2205	protein histidine kinase activity
BHS04_RS37090	COG0438	transferase activity, transferring glycosyl groups
BHS04_RS37095	COG0438	transferase activity, transferring glycosyl groups
BHS04_RS37120	COG1051	belongs to the nudix hydrolase family
BHS04_RS37120	COG1056	cytidyltransferase-related domain
BHS04_RS37130	COG1028	Short-chain dehydrogenase reductase Sdr
BHS04_RS37165	COG5002	protein histidine kinase activity
BHS04_RS37270	COG3842	ATPase activity
BHS04_RS37275	COG1127	ABC transporter
BHS04_RS37300	COG0596	Alpha beta hydrolase
BHS04_RS37335	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BHS04_RS37355	COG0515	serine threonine protein kinase
BHS04_RS37360	COG3932	Exopolysaccharide synthesis, ExoD
BHS04_RS37370	COG0702	epimerase
BHS04_RS37385	COG2815	serine threonine protein kinase
BHS04_RS37385	COG0515	serine threonine protein kinase
BHS04_RS37405	COG0667	Aldo Keto reductase
BHS04_RS37415	COG4279	zinc finger
BHS04_RS37420	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BHS04_RS37450	COG1653	transport
BHS04_RS37480	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BHS04_RS37495	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BHS04_RS37495	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
BHS04_RS37520	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
BHS04_RS37550	COG1960	acyl-CoA dehydrogenase activity
BHS04_RS37555	COG0583	DNA-binding transcription factor activity
BHS04_RS37575	COG1309	transcriptional regulator
BHS04_RS37595	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BHS04_RS37610	COG1064	alcohol dehydrogenase
BHS04_RS37620	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
BHS04_RS37620	COG2755	lipolytic protein G-D-S-L family
BHS04_RS37635	COG1404	Belongs to the peptidase S8 family
BHS04_RS37640	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
BHS04_RS37730	COG0242	peptide deformylase activity
BHS04_RS37765	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BHS04_RS37780	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BHS04_RS37795	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BHS04_RS37815	COG5002	protein histidine kinase activity
BHS04_RS37820	COG0745	RESPONSE REGULATOR receiver
BHS04_RS37830	COG5001	Diguanylate cyclase
BHS04_RS37845	COG2815	serine threonine protein kinase
BHS04_RS37845	COG0515	serine threonine protein kinase
BHS04_RS37870	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BHS04_RS37880	COG0003	Pfam Anion-transporting ATPase
BHS04_RS37885	COG0516	GMP reductase activity
BHS04_RS37885	COG0517	IMP dehydrogenase activity
BHS04_RS37920	COG3942	CHAP domain
BHS04_RS37920	COG1388	LysM domain
BHS04_RS37970	COG5002	protein histidine kinase activity
BHS04_RS37980	COG3483	tryptophan 2,3-dioxygenase activity
BHS04_RS38005	COG0506	proline dehydrogenase activity
BHS04_RS38010	COG3387	PFAM Glycoside hydrolase 15-related
BHS04_RS38025	COG2814	Major facilitator Superfamily
BHS04_RS38040	COG0746	molybdenum cofactor guanylyltransferase activity
BHS04_RS38045	COG0303	'Molybdopterin
BHS04_RS38055	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BHS04_RS38075	COG0745	RESPONSE REGULATOR receiver
BHS04_RS38105	COG2304	oxidoreductase activity
BHS04_RS38145	COG2239	Acts as a magnesium transporter
BHS04_RS38150	COG5002	protein histidine kinase activity
BHS04_RS38170	COG1045	serine acetyltransferase
BHS04_RS38265	COG0038	chloride channel
BHS04_RS38295	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BHS04_RS38300	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
BHS04_RS38320	COG1475	DNA binding
BHS04_RS38325	COG1192	Involved in chromosome partitioning
BHS04_RS38340	COG0357	Ribosomal RNA small subunit methyltransferase G
BHS04_RS38345	COG0445	tRNA wobble uridine modification
BHS04_RS38350	COG2814	Major facilitator Superfamily
BHS04_RS38355	COG2267	carboxylic ester hydrolase activity
BHS04_RS38365	COG0612	Peptidase, M16
BHS04_RS38370	COG0616	signal peptide processing
BHS04_RS38385	COG0640	Transcriptional regulator
BHS04_RS38390	COG3832	glyoxalase III activity
BHS04_RS38405	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BHS04_RS38420	COG0706	membrane insertase activity
BHS04_RS38425	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
BHS04_RS38430	COG0594	ribonuclease P activity
BHS04_RS38435	COG0230	Belongs to the bacterial ribosomal protein bL34 family