locus-tag	class	description
B1756_RS00015	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
B1756_RS00030	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
B1756_RS00045	COG0415	Belongs to the DNA photolyase family
B1756_RS00070	COG0523	cobalamin synthesis protein
B1756_RS00100	COG0673	inositol 2-dehydrogenase activity
B1756_RS00105	COG3842	ATPase activity
B1756_RS00135	COG0495	leucyl-tRNA aminoacylation
B1756_RS00150	COG0628	permease
B1756_RS00180	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
B1756_RS00185	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
B1756_RS00190	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B1756_RS00195	COG1295	ribonuclease BN
B1756_RS00220	COG0803	Belongs to the bacterial solute-binding protein 9 family
B1756_RS00220	COG3443	Belongs to the bacterial solute-binding protein 9 family
B1756_RS00225	COG1121	(ABC) transporter
B1756_RS00240	COG0857	belongs to the CobB CobQ family
B1756_RS00265	COG4191	Histidine kinase
B1756_RS00300	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
B1756_RS00320	COG0647	UMP catabolic process
B1756_RS00335	COG4770	biotin carboxylase activity
B1756_RS00345	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B1756_RS00360	COG0410	ABC transporter
B1756_RS00370	COG4177	L-phenylalanine transmembrane transporter activity
B1756_RS00375	COG0559	Belongs to the binding-protein-dependent transport system permease family
B1756_RS00380	COG0437	4 iron, 4 sulfur cluster binding
B1756_RS00400	COG0489	protein tyrosine kinase activity
B1756_RS00435	COG1131	(ABC) transporter
B1756_RS00445	COG4251	negative regulation of phosphorylation
B1756_RS00455	COG0668	transmembrane transport
B1756_RS00480	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
B1756_RS00490	COG0316	Belongs to the HesB IscA family
B1756_RS00495	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
B1756_RS00535	COG0644	oxidoreductase
B1756_RS00575	COG0587	DNA-directed DNA polymerase activity
B1756_RS00580	COG0367	asparagine synthase
B1756_RS00585	COG1506	peptidase
B1756_RS00590	COG0746	molybdenum cofactor guanylyltransferase activity
B1756_RS00610	COG0371	Dehydrogenase
B1756_RS00645	COG0069	glutamate synthase activity
B1756_RS00645	COG0070	glutamate synthase
B1756_RS00645	COG0067	glutamate synthase
B1756_RS00675	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
B1756_RS00680	COG0135	phosphoribosylanthranilate isomerase activity
B1756_RS00685	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
B1756_RS00720	COG1028	Short-chain dehydrogenase reductase Sdr
B1756_RS00745	COG0563	adenylate kinase activity
B1756_RS00765	COG0110	maltose O-acetyltransferase activity
B1756_RS00770	COG1252	NADH dehydrogenase
B1756_RS00795	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
B1756_RS00800	COG0187	DNA topoisomerase II activity
B1756_RS00805	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
B1756_RS00835	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
B1756_RS00915	COG0443	Heat shock 70 kDa protein
B1756_RS00920	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
B1756_RS00925	COG1028	Short-chain dehydrogenase reductase Sdr
B1756_RS00975	COG0596	Alpha beta hydrolase
B1756_RS00985	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
B1756_RS00985	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
B1756_RS00995	COG0154	amidase activity
B1756_RS01015	COG3842	ATPase activity
B1756_RS01020	COG0395	ABC-type sugar transport system, permease component
B1756_RS01045	COG0175	sulfate reduction
B1756_RS01060	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
B1756_RS01070	COG2391	methyltransferase activity
B1756_RS01090	COG0517	IMP dehydrogenase activity
B1756_RS01090	COG0516	GMP reductase activity
B1756_RS01110	COG0330	HflC and HflK could
B1756_RS01120	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
B1756_RS01130	COG3252	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT
B1756_RS01145	COG0281	malic enzyme
B1756_RS01145	COG0280	phosphate acetyltransferase
B1756_RS01150	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
B1756_RS01210	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B1756_RS01235	COG3243	poly(R)-hydroxyalkanoic acid synthase
B1756_RS01240	COG1028	Short-chain dehydrogenase reductase Sdr
B1756_RS01250	COG0315	cyclic pyranopterin monophosphate synthase activity
B1756_RS01255	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
B1756_RS01255	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
B1756_RS01270	COG1254	Belongs to the acylphosphatase family
B1756_RS01325	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
B1756_RS01335	COG0089	rRNA binding
B1756_RS01340	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
B1756_RS01345	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
B1756_RS01355	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
B1756_RS01360	COG0255	Belongs to the universal ribosomal protein uL29 family
B1756_RS01370	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
B1756_RS01375	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
B1756_RS01390	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
B1756_RS01400	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
B1756_RS01425	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
B1756_RS01435	COG0200	Binds to the 23S rRNA
B1756_RS01500	COG1051	belongs to the nudix hydrolase family
B1756_RS01505	COG0442	prolyl-tRNA aminoacylation
B1756_RS01510	COG3639	organic phosphonate transmembrane transporter activity
B1756_RS01515	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
B1756_RS01535	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B1756_RS01550	COG0129	dihydroxy-acid dehydratase activity
B1756_RS01560	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
B1756_RS01560	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
B1756_RS01570	COG1185	polyribonucleotide nucleotidyltransferase activity
B1756_RS01580	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
B1756_RS01585	COG0391	Required for morphogenesis under gluconeogenic growth conditions
B1756_RS01590	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B1756_RS01600	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
B1756_RS01610	COG1960	acyl-CoA dehydrogenase activity
B1756_RS01625	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B1756_RS01635	COG0604	alcohol dehydrogenase
B1756_RS01655	COG0436	Aminotransferase
B1756_RS01670	COG1013	pyruvate-flavodoxin oxidoreductase activity
B1756_RS01675	COG0674	pyruvate-flavodoxin oxidoreductase activity
B1756_RS01675	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
B1756_RS01685	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
B1756_RS01690	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B1756_RS01755	COG0719	Fe-S assembly protein
B1756_RS01760	COG0719	Fe-S assembly protein
B1756_RS01765	COG0396	ATPase activity
B1756_RS01790	COG0419	ATPase involved in DNA repair
B1756_RS01795	COG0420	3'-5' exonuclease activity
B1756_RS01805	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B1756_RS01810	COG0518	GMP synthase (glutamine-hydrolyzing) activity
B1756_RS01810	COG0519	Catalyzes the synthesis of GMP from XMP
B1756_RS01845	COG0628	permease
B1756_RS01880	COG2267	carboxylic ester hydrolase activity
B1756_RS01885	COG2030	dehydratase
B1756_RS01890	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B1756_RS01905	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
B1756_RS01915	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
B1756_RS01920	COG0066	3-isopropylmalate dehydratase activity
B1756_RS01930	COG0473	3-isopropylmalate dehydrogenase activity
B1756_RS01960	COG1121	(ABC) transporter
B1756_RS01975	COG2217	Heavy metal translocating P-type atpase
B1756_RS02005	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
B1756_RS02015	COG1268	BioY protein
B1756_RS02040	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B1756_RS02060	COG1363	Peptidase, m42
B1756_RS02075	COG0492	ferredoxin-NADP+ reductase activity
B1756_RS02085	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
B1756_RS02090	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
B1756_RS02110	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
B1756_RS02145	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
B1756_RS02150	COG0589	response to stress
B1756_RS02150	COG0475	glutathione-regulated potassium exporter activity
B1756_RS02165	COG0589	response to stress
B1756_RS02180	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
B1756_RS02185	COG0561	phosphatase activity
B1756_RS02185	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B1756_RS02250	COG0517	IMP dehydrogenase activity
B1756_RS02265	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B1756_RS02265	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B1756_RS02320	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
B1756_RS02330	COG0559	Belongs to the binding-protein-dependent transport system permease family
B1756_RS02350	COG0318	PFAM AMP-dependent synthetase and ligase
B1756_RS02450	COG1797	cobyrinic acid a,c-diamide synthase activity
B1756_RS02455	COG0346	lactoylglutathione lyase activity
B1756_RS02460	COG0284	orotidine-5'-phosphate decarboxylase activity
B1756_RS02500	COG0142	geranyltranstransferase activity
B1756_RS02510	COG0531	amino acid
B1756_RS02535	COG2337	Toxic component of a toxin-antitoxin (TA) module
B1756_RS02570	COG0287	Prephenate dehydrogenase
B1756_RS02570	COG1605	Chorismate mutase
B1756_RS02585	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B1756_RS02585	COG0574	Belongs to the PEP-utilizing enzyme family
B1756_RS02590	COG3848	Pyruvate phosphate dikinase
B1756_RS02590	COG0574	Belongs to the PEP-utilizing enzyme family
B1756_RS02615	COG4638	Rieske (2fe-2S)
B1756_RS02655	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B1756_RS02660	COG0688	phosphatidylethanolamine metabolic process
B1756_RS02675	COG0643	Histidine kinase
B1756_RS02675	COG2198	Histidine kinase
B1756_RS02680	COG2201	protein-glutamate methylesterase activity
B1756_RS02685	COG1192	Involved in chromosome partitioning
B1756_RS02695	COG0784	Response regulator, receiver
B1756_RS02695	COG0835	chemotaxis
B1756_RS02700	COG0840	transmembrane signaling receptor activity
B1756_RS02710	COG2201	protein-glutamate methylesterase activity
B1756_RS02785	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B1756_RS02790	COG0832	Belongs to the urease beta subunit family
B1756_RS02790	COG0831	urea catabolic process
B1756_RS02795	COG0804	urea catabolic process
B1756_RS02800	COG0804	urea catabolic process
B1756_RS02815	COG0829	nickel cation binding
B1756_RS02820	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
B1756_RS02825	COG0830	nickel cation binding
B1756_RS02845	COG0667	Aldo Keto reductase
B1756_RS02870	COG1131	(ABC) transporter
B1756_RS02910	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B1756_RS02940	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B1756_RS02965	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
B1756_RS03015	COG0277	FAD linked oxidase domain protein
B1756_RS03050	COG0052	Belongs to the universal ribosomal protein uS2 family
B1756_RS03055	COG0148	phosphopyruvate hydratase activity
B1756_RS03070	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
B1756_RS03095	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
B1756_RS03100	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
B1756_RS03105	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
B1756_RS03130	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
B1756_RS03155	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B1756_RS03160	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
B1756_RS03165	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
B1756_RS03175	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
B1756_RS03200	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
B1756_RS03205	COG2226	methyltransferase
B1756_RS03225	COG2201	protein-glutamate methylesterase activity
B1756_RS03230	COG2201	protein-glutamate methylesterase activity
B1756_RS03235	COG2198	Histidine kinase
B1756_RS03235	COG0643	Histidine kinase
B1756_RS03235	COG2198	Histidine kinase
B1756_RS03235	COG0643	Histidine kinase
B1756_RS03250	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
B1756_RS03255	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
B1756_RS03295	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
B1756_RS03300	COG4251	negative regulation of phosphorylation
B1756_RS03305	COG1028	Short-chain dehydrogenase reductase Sdr
B1756_RS03335	COG2855	membrane
B1756_RS03345	COG0573	inorganic phosphate transmembrane transporter activity
B1756_RS03350	COG0581	inorganic phosphate transmembrane transporter activity
B1756_RS03355	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
B1756_RS03365	COG0133	tryptophan synthase activity
B1756_RS03400	COG0717	Belongs to the dCTP deaminase family
B1756_RS03420	COG2226	methyltransferase
B1756_RS03445	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
B1756_RS03470	COG0704	Plays a role in the regulation of phosphate uptake
B1756_RS03475	COG1177	transmembrane transport
B1756_RS03485	COG3842	ATPase activity
B1756_RS03500	COG0644	oxidoreductase
B1756_RS03510	COG2086	electron transfer activity
B1756_RS03520	COG0649	NAD binding
B1756_RS03520	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B1756_RS03520	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B1756_RS03535	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
B1756_RS03570	COG1098	S1 RNA binding domain
B1756_RS03615	COG4608	Belongs to the ABC transporter superfamily
B1756_RS03620	COG0444	Belongs to the ABC transporter superfamily
B1756_RS03625	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B1756_RS03630	COG0601	transmembrane transport
B1756_RS03665	COG0438	transferase activity, transferring glycosyl groups
B1756_RS03680	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
B1756_RS03695	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
B1756_RS03705	COG0651	ATP synthesis coupled electron transport
B1756_RS03710	COG0651	ATP synthesis coupled electron transport
B1756_RS03715	COG0651	ATP synthesis coupled electron transport
B1756_RS03720	COG1006	Multisubunit Na H antiporter MnhC subunit
B1756_RS03735	COG1320	monovalent cation:proton antiporter activity
B1756_RS03765	COG0668	transmembrane transport
B1756_RS03775	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
B1756_RS03875	COG0437	4 iron, 4 sulfur cluster binding
B1756_RS03885	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B1756_RS03890	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
B1756_RS03900	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
B1756_RS03910	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
B1756_RS04030	COG0791	NLP P60 protein
B1756_RS04030	COG1388	LysM domain
B1756_RS04080	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
B1756_RS04090	COG1185	polyribonucleotide nucleotidyltransferase activity
B1756_RS04135	COG1185	polyribonucleotide nucleotidyltransferase activity
B1756_RS04160	COG2226	methyltransferase
B1756_RS04165	COG0179	Fumarylacetoacetate (FAA) hydrolase
B1756_RS04205	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B1756_RS04205	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B1756_RS04225	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B1756_RS04240	COG1573	uracil-dna glycosylase
B1756_RS04260	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B1756_RS04265	COG3268	Saccharopine dehydrogenase
B1756_RS04295	COG0714	Associated with various cellular activities
B1756_RS04300	COG1278	Cold shock
B1756_RS04320	COG0778	Nitroreductase
B1756_RS04320	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
B1756_RS04345	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
B1756_RS04350	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
B1756_RS04360	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
B1756_RS04395	COG0464	growth
B1756_RS04415	COG0589	response to stress
B1756_RS04445	COG0009	L-threonylcarbamoyladenylate synthase
B1756_RS04455	COG0714	Associated with various cellular activities
B1756_RS04460	COG1960	acyl-CoA dehydrogenase activity
B1756_RS04475	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
B1756_RS04485	COG2267	carboxylic ester hydrolase activity
B1756_RS04495	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B1756_RS04540	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B1756_RS04545	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
B1756_RS04565	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
B1756_RS04570	COG0800	Aldolase
B1756_RS04575	COG1063	alcohol dehydrogenase
B1756_RS04580	COG4948	Mandelate Racemase Muconate Lactonizing
B1756_RS04585	COG3387	PFAM Glycoside hydrolase 15-related
B1756_RS04590	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B1756_RS04635	COG1796	DNA polymerase
B1756_RS04635	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
B1756_RS04655	COG1515	deoxyribonuclease V activity
B1756_RS04660	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
B1756_RS04675	COG0822	iron-sulfur transferase activity
B1756_RS04680	COG2204	response regulator
B1756_RS04725	COG0446	pyridine nucleotide-disulphide oxidoreductase
B1756_RS04735	COG1271	oxidase subunit
B1756_RS04795	COG2204	response regulator
B1756_RS04865	COG0459	protein refolding
B1756_RS04870	COG0521	Mo-molybdopterin cofactor biosynthetic process
B1756_RS04920	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B1756_RS04920	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B1756_RS04930	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B1756_RS05000	COG1404	Belongs to the peptidase S8 family
B1756_RS05005	COG1960	acyl-CoA dehydrogenase activity
B1756_RS05020	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
B1756_RS05025	COG0596	Alpha beta hydrolase
B1756_RS05045	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B1756_RS05050	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B1756_RS05070	COG0765	amino acid transport
B1756_RS05080	COG0765	amino acid transport
B1756_RS05090	COG0306	phosphate transporter
B1756_RS05100	COG1253	flavin adenine dinucleotide binding
B1756_RS05130	COG1840	ABC-type Fe3 transport system, periplasmic component
B1756_RS05135	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
B1756_RS05150	COG0218	Necessary for normal cell division and for the maintenance of normal septation
B1756_RS05155	COG1028	Short-chain dehydrogenase reductase Sdr
B1756_RS05190	COG4251	negative regulation of phosphorylation
B1756_RS05205	COG0085	RNA polymerase activity
B1756_RS05210	COG0085	RNA polymerase activity
B1756_RS05215	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
B1756_RS05220	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
B1756_RS05245	COG0049	tRNA binding
B1756_RS05265	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
B1756_RS05275	COG1028	Short-chain dehydrogenase reductase Sdr
B1756_RS05315	COG0512	Glutamine amidotransferase of anthranilate synthase
B1756_RS05320	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
B1756_RS05340	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
B1756_RS05350	COG0475	glutathione-regulated potassium exporter activity
B1756_RS05350	COG0589	response to stress
B1756_RS05355	COG0616	signal peptide processing
B1756_RS05360	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
B1756_RS05370	COG1278	Cold shock
B1756_RS05375	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
B1756_RS05375	COG0512	Glutamine amidotransferase of anthranilate synthase
B1756_RS05385	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
B1756_RS05395	COG0438	transferase activity, transferring glycosyl groups
B1756_RS05400	COG1086	Polysaccharide biosynthesis protein
B1756_RS05435	COG1028	Short-chain dehydrogenase reductase Sdr
B1756_RS05435	COG3321	synthase
B1756_RS05435	COG0604	alcohol dehydrogenase
B1756_RS05450	COG0518	GMP synthase (glutamine-hydrolyzing) activity
B1756_RS05450	COG0519	Catalyzes the synthesis of GMP from XMP
B1756_RS05455	COG0504	CTP synthase activity
B1756_RS05485	COG0288	reversible hydration of carbon dioxide
B1756_RS05490	COG2130	NADP-dependent
B1756_RS05500	COG0842	Transport permease protein
B1756_RS05505	COG1131	(ABC) transporter
B1756_RS05550	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
B1756_RS05560	COG0140	phosphoribosyl-ATP diphosphatase activity
B1756_RS05585	COG0530	calcium, potassium:sodium antiporter activity
B1756_RS05590	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B1756_RS05595	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B1756_RS05595	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B1756_RS05605	COG0784	Response regulator, receiver
B1756_RS05610	COG0166	Belongs to the GPI family
B1756_RS05630	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
B1756_RS05645	COG1278	Cold shock
B1756_RS05680	COG0438	transferase activity, transferring glycosyl groups
B1756_RS05690	COG1063	alcohol dehydrogenase
B1756_RS05745	COG0438	transferase activity, transferring glycosyl groups
B1756_RS05765	COG0798	PFAM Bile acid sodium symporter
B1756_RS05775	COG0668	transmembrane transport
B1756_RS05785	COG0495	leucyl-tRNA aminoacylation
B1756_RS05795	COG0247	lactate metabolic process
B1756_RS05795	COG2181	nitrate reductase activity
B1756_RS05805	COG1476	TRANSCRIPTIONal
B1756_RS05815	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B1756_RS05825	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
B1756_RS05840	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
B1756_RS05875	COG4974	Belongs to the 'phage' integrase family
B1756_RS05895	COG3385	transposase activity
B1756_RS05915	COG3385	transposase activity
B1756_RS05930	COG4974	Belongs to the 'phage' integrase family
B1756_RS05990	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
B1756_RS05995	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
B1756_RS06030	COG1914	H( )-stimulated, divalent metal cation uptake system
B1756_RS06070	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
B1756_RS06075	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
B1756_RS06085	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
B1756_RS06095	COG0788	formyltetrahydrofolate deformylase activity
B1756_RS06115	COG0523	cobalamin synthesis protein
B1756_RS06135	COG2223	nitrite transmembrane transporter activity
B1756_RS06150	COG0047	phosphoribosylformylglycinamidine synthase activity
B1756_RS06165	COG1250	3-hydroxyacyl-CoA dehydrogenase
B1756_RS06205	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
B1756_RS06255	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
B1756_RS06260	COG1012	belongs to the aldehyde dehydrogenase family
B1756_RS06265	COG0783	Belongs to the Dps family
B1756_RS06270	COG0517	IMP dehydrogenase activity
B1756_RS06280	COG1011	Hydrolase
B1756_RS06285	COG1028	Short-chain dehydrogenase reductase Sdr
B1756_RS06320	COG0180	Tryptophanyl-tRNA synthetase
B1756_RS06360	COG0840	transmembrane signaling receptor activity
B1756_RS06365	COG0077	Prephenate dehydratase
B1756_RS06380	COG2309	aminopeptidase activity
B1756_RS06445	COG1132	(ABC) transporter
B1756_RS06490	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B1756_RS06490	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B1756_RS06495	COG0733	neurotransmitter:sodium symporter activity
B1756_RS06510	COG0076	glutamate decarboxylase activity
B1756_RS06560	COG0384	phenazine biosynthesis protein PhzF
B1756_RS06570	COG3290	protein histidine kinase activity
B1756_RS06570	COG0840	transmembrane signaling receptor activity
B1756_RS06575	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
B1756_RS06580	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
B1756_RS06590	COG0534	Mate efflux family protein
B1756_RS06610	COG1196	nuclear chromosome segregation
B1756_RS06625	COG0559	Belongs to the binding-protein-dependent transport system permease family
B1756_RS06635	COG0411	ABC transporter
B1756_RS06650	COG1028	Short-chain dehydrogenase reductase Sdr
B1756_RS06655	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B1756_RS06660	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
B1756_RS06700	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
B1756_RS06700	COG0116	Belongs to the methyltransferase superfamily
B1756_RS06720	COG1234	tRNA 3'-trailer cleavage
B1756_RS06875	COG5487	UPF0391 membrane protein
B1756_RS06880	COG2202	Pas domain
B1756_RS06880	COG1366	Belongs to the anti-sigma-factor antagonist family
B1756_RS06920	COG0601	transmembrane transport
B1756_RS06925	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B1756_RS06930	COG0444	Belongs to the ABC transporter superfamily
B1756_RS06935	COG4608	Belongs to the ABC transporter superfamily
B1756_RS06960	COG2226	methyltransferase
B1756_RS06965	COG1024	Enoyl-CoA hydratase
B1756_RS07010	COG2217	Heavy metal translocating P-type atpase
B1756_RS07050	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
B1756_RS07055	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
B1756_RS07080	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B1756_RS07085	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B1756_RS07095	COG1012	belongs to the aldehyde dehydrogenase family
B1756_RS07105	COG1960	acyl-CoA dehydrogenase activity
B1756_RS07110	COG1960	acyl-CoA dehydrogenase activity
B1756_RS07115	COG1024	Enoyl-CoA hydratase
B1756_RS07130	COG1028	Short-chain dehydrogenase reductase Sdr
B1756_RS07135	COG0318	PFAM AMP-dependent synthetase and ligase
B1756_RS07190	COG1172	Belongs to the binding-protein-dependent transport system permease family
B1756_RS07210	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
B1756_RS07250	COG1024	Enoyl-CoA hydratase
B1756_RS07255	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B1756_RS07265	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
B1756_RS07285	COG1024	Enoyl-CoA hydratase
B1756_RS07305	COG3383	formate dehydrogenase (NAD+) activity
B1756_RS07310	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
B1756_RS07340	COG0556	nucleotide-excision repair
B1756_RS07345	COG1247	-acetyltransferase
B1756_RS07355	COG1247	-acetyltransferase
B1756_RS07375	COG0322	excinuclease ABC activity
B1756_RS07385	COG3361	conserved protein (COG2071)
B1756_RS07395	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
B1756_RS07465	COG1335	isochorismatase
B1756_RS07475	COG0113	porphobilinogen synthase activity
B1756_RS07500	COG1064	alcohol dehydrogenase
B1756_RS07540	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
B1756_RS07550	COG0501	Belongs to the peptidase M48B family
B1756_RS07560	COG1199	ATP-dependent helicase activity
B1756_RS07565	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
B1756_RS07600	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
B1756_RS07710	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B1756_RS07715	COG0352	thiamine-phosphate diphosphorylase activity
B1756_RS07720	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
B1756_RS07825	COG1404	Belongs to the peptidase S8 family
B1756_RS07830	COG0003	Pfam Anion-transporting ATPase
B1756_RS07840	COG1131	(ABC) transporter
B1756_RS07845	COG0523	cobalamin synthesis protein
B1756_RS07850	COG0523	cobalamin synthesis protein
B1756_RS07875	COG1606	tRNA processing
B1756_RS07885	COG0805	protein transport
B1756_RS07890	COG0805	protein transport
B1756_RS07900	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
B1756_RS07920	COG1215	transferase activity, transferring glycosyl groups
B1756_RS07935	COG2204	response regulator
B1756_RS07940	COG4191	Histidine kinase
B1756_RS07940	COG0784	Response regulator, receiver
B1756_RS07945	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
B1756_RS07950	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
B1756_RS08000	COG4251	negative regulation of phosphorylation
B1756_RS08010	COG1045	serine acetyltransferase
B1756_RS08025	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B1756_RS08035	COG2827	Endonuclease containing a URI domain
B1756_RS08040	COG1691	(AIR) carboxylase
B1756_RS08050	COG1304	FMN binding
B1756_RS08060	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
B1756_RS08090	COG0527	aspartate kinase activity
B1756_RS08115	COG1160	GTP binding
B1756_RS08145	COG2226	methyltransferase
B1756_RS08185	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
B1756_RS08205	COG0519	Catalyzes the synthesis of GMP from XMP
B1756_RS08205	COG0518	GMP synthase (glutamine-hydrolyzing) activity
B1756_RS08215	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
B1756_RS08220	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
B1756_RS08225	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B1756_RS08230	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B1756_RS08235	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
B1756_RS08240	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
B1756_RS08245	COG0189	ligase activity
B1756_RS08255	COG0165	Argininosuccinate lyase
B1756_RS08260	COG0137	argininosuccinate synthase activity
B1756_RS08285	COG1902	pentaerythritol trinitrate reductase activity
B1756_RS08305	COG1064	alcohol dehydrogenase
B1756_RS08355	COG0039	L-malate dehydrogenase activity
B1756_RS08375	COG3011	Protein conserved in bacteria
B1756_RS08385	COG0556	nucleotide-excision repair
B1756_RS08440	COG0423	glycine-tRNA ligase activity
B1756_RS08460	COG4608	Belongs to the ABC transporter superfamily
B1756_RS08465	COG0444	Belongs to the ABC transporter superfamily
B1756_RS08470	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B1756_RS08475	COG0601	transmembrane transport
B1756_RS08480	COG4166	transmembrane transport
B1756_RS08530	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
B1756_RS08565	COG1648	precorrin-2 dehydrogenase activity
B1756_RS08565	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
B1756_RS08570	COG0181	hydroxymethylbilane synthase activity
B1756_RS08580	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
B1756_RS08590	COG0004	ammonium transporteR
B1756_RS08600	COG2217	Heavy metal translocating P-type atpase
B1756_RS08655	COG0714	Associated with various cellular activities
B1756_RS08665	COG0131	Imidazoleglycerol-phosphate dehydratase
B1756_RS08775	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B1756_RS08830	COG0346	lactoylglutathione lyase activity
B1756_RS08835	COG3634	alkyl hydroperoxide reductase activity
B1756_RS08890	COG0560	Phosphoserine phosphatase
B1756_RS08910	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
B1756_RS08915	COG2873	o-acetylhomoserine
B1756_RS08940	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
B1756_RS08960	COG0402	S-adenosylhomocysteine deaminase activity
B1756_RS08970	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
B1756_RS09045	COG3119	arylsulfatase activity
B1756_RS09055	COG1028	Short-chain dehydrogenase reductase Sdr
B1756_RS09095	COG0183	Belongs to the thiolase family
B1756_RS09105	COG2414	aldehyde ferredoxin oxidoreductase
B1756_RS09110	COG1022	Amp-dependent synthetase and ligase
B1756_RS09115	COG1022	Amp-dependent synthetase and ligase
B1756_RS09120	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B1756_RS09125	COG3852	Histidine kinase
B1756_RS09135	COG0528	UMP kinase activity
B1756_RS09145	COG0314	molybdopterin synthase activity
B1756_RS09185	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B1756_RS09225	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
B1756_RS09235	COG0022	dehydrogenase e1 component
B1756_RS09320	COG3385	transposase activity
B1756_RS09440	COG3385	transposase activity
B1756_RS09475	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
B1756_RS09525	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
B1756_RS09540	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B1756_RS09545	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
B1756_RS09550	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
B1756_RS09565	COG0714	Associated with various cellular activities
B1756_RS09615	COG0367	asparagine synthase
B1756_RS09625	COG1132	(ABC) transporter
B1756_RS09645	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B1756_RS09685	COG0438	transferase activity, transferring glycosyl groups
B1756_RS09685	COG0297	glycogen (starch) synthase activity
B1756_RS09695	COG0297	glycogen (starch) synthase activity
B1756_RS09695	COG0438	transferase activity, transferring glycosyl groups
B1756_RS09705	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
B1756_RS09710	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
B1756_RS09750	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
B1756_RS09770	COG4221	oxidoreductase activity
B1756_RS09785	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
B1756_RS09870	COG1121	(ABC) transporter
B1756_RS09895	COG2226	methyltransferase
B1756_RS09915	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
B1756_RS09925	COG0723	plastoquinol--plastocyanin reductase activity
B1756_RS09955	COG0151	Belongs to the GarS family
B1756_RS09965	COG1285	pathogenesis
B1756_RS09985	COG5278	phosphoserine phosphatase activity
B1756_RS09985	COG0840	transmembrane signaling receptor activity
B1756_RS09990	COG0142	geranyltranstransferase activity
B1756_RS10005	COG4191	Histidine kinase
B1756_RS10040	COG1269	ATP hydrolysis coupled proton transport
B1756_RS10065	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
B1756_RS10080	COG0318	PFAM AMP-dependent synthetase and ligase
B1756_RS10085	COG0318	PFAM AMP-dependent synthetase and ligase
B1756_RS10125	COG4251	negative regulation of phosphorylation
B1756_RS10135	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B1756_RS10155	COG1164	Oligoendopeptidase f
B1756_RS10180	COG2226	methyltransferase
B1756_RS10190	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B1756_RS10190	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B1756_RS10195	COG0351	phosphomethylpyrimidine kinase
B1756_RS10220	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
B1756_RS10235	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
B1756_RS10290	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
B1756_RS10300	COG0589	response to stress
B1756_RS10305	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
B1756_RS10315	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
B1756_RS10345	COG0683	leucine binding
B1756_RS10360	COG0083	homoserine kinase activity
B1756_RS10380	COG0531	amino acid
B1756_RS10400	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
B1756_RS10410	COG0210	DNA helicase
B1756_RS10430	COG2339	peptidase activity
B1756_RS10440	COG0494	nUDIX hydrolase
B1756_RS10445	COG0385	Bile acid
B1756_RS10490	COG2894	cell division
B1756_RS10500	COG0018	arginyl-trna synthetase
B1756_RS10520	COG3608	succinylglutamate desuccinylase aspartoacylase
B1756_RS10525	COG0404	The glycine cleavage system catalyzes the degradation of glycine
B1756_RS10550	COG3253	May function as heme-dependent peroxidase
B1756_RS10555	COG1695	Transcriptional regulator
B1756_RS10560	COG0750	zinc metalloprotease
B1756_RS10575	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
B1756_RS10585	COG2239	Acts as a magnesium transporter
B1756_RS10615	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
B1756_RS10635	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
B1756_RS10685	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
B1756_RS10690	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B1756_RS10710	COG1233	COG1233 Phytoene dehydrogenase and related
B1756_RS10715	COG2988	succinylglutamate desuccinylase activity
B1756_RS10725	COG2311	Membrane
B1756_RS10730	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
B1756_RS10735	COG1250	3-hydroxyacyl-CoA dehydrogenase
B1756_RS10750	COG1201	RNA secondary structure unwinding
B1756_RS10780	COG1234	tRNA 3'-trailer cleavage
B1756_RS10855	COG0673	inositol 2-dehydrogenase activity
B1756_RS10865	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B1756_RS10880	COG0601	transmembrane transport
B1756_RS10885	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B1756_RS10895	COG0747	negative chemotaxis
B1756_RS10905	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
B1756_RS10910	COG0673	inositol 2-dehydrogenase activity
B1756_RS10970	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
B1756_RS10985	COG0444	Belongs to the ABC transporter superfamily
B1756_RS10990	COG4608	Belongs to the ABC transporter superfamily
B1756_RS11005	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B1756_RS11010	COG4948	Mandelate Racemase Muconate Lactonizing
B1756_RS11015	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
B1756_RS11070	COG0167	dihydroorotate dehydrogenase activity
B1756_RS11100	COG1201	RNA secondary structure unwinding
B1756_RS11135	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B1756_RS11165	COG1215	transferase activity, transferring glycosyl groups
B1756_RS11175	COG0494	nUDIX hydrolase
B1756_RS11195	COG3548	integral membrane protein
B1756_RS11220	COG0557	exoribonuclease II activity
B1756_RS11235	COG0430	RNA-3'-phosphate cyclase activity
B1756_RS11240	COG2153	protein acetylation
B1756_RS11260	COG1136	(ABC) transporter
B1756_RS11265	COG0577	efflux transmembrane transporter activity
B1756_RS11275	COG0784	Response regulator, receiver
B1756_RS11275	COG4191	Histidine kinase
B1756_RS11280	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
B1756_RS11285	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
B1756_RS11315	COG0157	Belongs to the NadC ModD family
B1756_RS11320	COG0318	PFAM AMP-dependent synthetase and ligase
B1756_RS11330	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
B1756_RS11335	COG1250	3-hydroxyacyl-CoA dehydrogenase
B1756_RS11345	COG0318	PFAM AMP-dependent synthetase and ligase
B1756_RS11350	COG2030	dehydratase
B1756_RS11360	COG0183	Belongs to the thiolase family
B1756_RS11370	COG1960	acyl-CoA dehydrogenase activity
B1756_RS11390	COG3842	ATPase activity
B1756_RS11395	COG0395	ABC-type sugar transport system, permease component
B1756_RS11400	COG1175	transmembrane transport
B1756_RS11405	COG1028	Short-chain dehydrogenase reductase Sdr
B1756_RS11425	COG1960	acyl-CoA dehydrogenase activity
B1756_RS11435	COG0534	Mate efflux family protein
B1756_RS11440	COG1028	Short-chain dehydrogenase reductase Sdr
B1756_RS11480	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
B1756_RS11495	COG0330	HflC and HflK could
B1756_RS11510	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
B1756_RS11520	COG0710	3-dehydroquinate dehydratase activity
B1756_RS11590	COG1465	3-dehydroquinate synthase
B1756_RS11620	COG1067	ATP-dependent peptidase activity
B1756_RS11620	COG0470	DNA polymerase III
B1756_RS11625	COG1056	cytidyltransferase-related domain
B1756_RS11625	COG1051	belongs to the nudix hydrolase family
B1756_RS11640	COG0459	protein refolding
B1756_RS11675	COG0252	asparaginase activity
B1756_RS11695	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
B1756_RS11695	COG1648	precorrin-2 dehydrogenase activity
B1756_RS11715	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
B1756_RS11790	COG0483	inositol monophosphate 1-phosphatase activity
B1756_RS11795	COG0517	IMP dehydrogenase activity
B1756_RS11805	COG2154	pterin-4-alpha-carbinolamine dehydratase
B1756_RS11810	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
B1756_RS11815	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
B1756_RS11815	COG1648	precorrin-2 dehydrogenase activity
B1756_RS11835	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
B1756_RS11850	COG0358	DNA primase activity
B1756_RS11890	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B1756_RS11900	COG0189	ligase activity
B1756_RS11950	COG0596	Alpha beta hydrolase
B1756_RS11955	COG0525	valine-tRNA ligase activity
B1756_RS11975	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
B1756_RS11980	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B1756_RS11985	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B1756_RS11990	COG4865	methylaspartate mutase activity
B1756_RS12050	COG0489	protein tyrosine kinase activity
B1756_RS12075	COG2719	SpoVR family
B1756_RS12090	COG2766	serine protein kinase
B1756_RS12105	COG0589	response to stress
B1756_RS12110	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B1756_RS12120	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B1756_RS12130	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B1756_RS12150	COG1899	peptidyl-lysine modification to peptidyl-hypusine
B1756_RS12165	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
B1756_RS12205	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
B1756_RS12215	COG0303	'Molybdopterin
B1756_RS12230	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
B1756_RS12255	COG0501	Belongs to the peptidase M48B family
B1756_RS12285	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
B1756_RS12290	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
B1756_RS12300	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
B1756_RS12360	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B1756_RS12390	COG0561	phosphatase activity
B1756_RS12405	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
B1756_RS12410	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
B1756_RS12420	COG0247	lactate metabolic process
B1756_RS12450	COG2897	thiosulfate sulfurtransferase activity
B1756_RS12480	COG2239	Acts as a magnesium transporter
B1756_RS12485	COG0501	Belongs to the peptidase M48B family
B1756_RS12490	COG0501	Belongs to the peptidase M48B family
B1756_RS12550	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
B1756_RS12560	COG1234	tRNA 3'-trailer cleavage
B1756_RS12570	COG1378	Sugar-specific transcriptional regulator TrmB
B1756_RS12585	COG0531	amino acid
B1756_RS12600	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
B1756_RS12610	COG2264	protein methyltransferase activity
B1756_RS12670	COG1378	Sugar-specific transcriptional regulator TrmB
B1756_RS12715	COG3385	transposase activity
B1756_RS12750	COG2226	methyltransferase
B1756_RS12765	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
B1756_RS12775	COG0247	lactate metabolic process
B1756_RS12775	COG0277	FAD linked oxidase domain protein
B1756_RS12785	COG0183	Belongs to the thiolase family
B1756_RS12790	COG1960	acyl-CoA dehydrogenase activity
B1756_RS12795	COG0318	PFAM AMP-dependent synthetase and ligase
B1756_RS12820	COG1960	acyl-CoA dehydrogenase activity
B1756_RS12825	COG1414	Transcriptional regulator
B1756_RS12850	COG0411	ABC transporter
B1756_RS12870	COG0318	PFAM AMP-dependent synthetase and ligase
B1756_RS12880	COG0183	Belongs to the thiolase family
B1756_RS12885	COG1250	3-hydroxyacyl-CoA dehydrogenase
B1756_RS12900	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B1756_RS12925	COG0179	Fumarylacetoacetate (FAA) hydrolase
B1756_RS12930	COG0045	succinate-CoA ligase (ADP-forming) activity
B1756_RS12945	COG1414	Transcriptional regulator
B1756_RS12960	COG1028	Short-chain dehydrogenase reductase Sdr
B1756_RS12975	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
B1756_RS13045	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
B1756_RS13050	COG4251	negative regulation of phosphorylation
B1756_RS13070	COG0372	Belongs to the citrate synthase family
B1756_RS13110	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
B1756_RS13135	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
B1756_RS13145	COG0589	response to stress
B1756_RS13150	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
B1756_RS13150	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
B1756_RS13160	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
B1756_RS13175	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B1756_RS13195	COG0657	acetylesterase activity
B1756_RS13205	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
B1756_RS13235	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
B1756_RS13260	COG0778	Nitroreductase
B1756_RS13265	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
B1756_RS13270	COG2171	N-acyltransferase activity
B1756_RS13275	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
B1756_RS13280	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B1756_RS13350	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
B1756_RS13375	COG0019	diaminopimelate decarboxylase activity
B1756_RS13385	COG0517	IMP dehydrogenase activity
B1756_RS13400	COG1024	Enoyl-CoA hydratase
B1756_RS13405	COG3246	L-lysine catabolic process to acetate
B1756_RS13410	COG0300	oxidoreductase activity
B1756_RS13420	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B1756_RS13440	COG0501	Belongs to the peptidase M48B family
B1756_RS13450	COG0318	PFAM AMP-dependent synthetase and ligase
B1756_RS13460	COG0138	bifunctional purine biosynthesis protein purh
B1756_RS13490	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
B1756_RS13495	COG0037	tRNA processing
B1756_RS13500	COG1024	Enoyl-CoA hydratase
B1756_RS13520	COG4106	trans-aconitate 2-methyltransferase activity
B1756_RS13525	COG0589	response to stress
B1756_RS13545	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
B1756_RS13550	COG0095	Lipoate-protein ligase
B1756_RS13555	COG0012	GTP binding
B1756_RS13585	COG0183	Belongs to the thiolase family
B1756_RS13610	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
B1756_RS13620	COG0668	transmembrane transport
B1756_RS13645	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
B1756_RS13650	COG0673	inositol 2-dehydrogenase activity
B1756_RS13675	COG3685	Protein conserved in bacteria
B1756_RS13705	COG0463	Glycosyl transferase, family 2
B1756_RS13710	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
B1756_RS13715	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
B1756_RS13720	COG4191	Histidine kinase
B1756_RS13735	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B1756_RS13740	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B1756_RS13780	COG3385	transposase activity
B1756_RS13850	COG1966	Carbon starvation protein
B1756_RS13870	COG0523	cobalamin synthesis protein
B1756_RS13885	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
B1756_RS13905	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B1756_RS13910	COG1233	COG1233 Phytoene dehydrogenase and related
B1756_RS13925	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
B1756_RS13930	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
B1756_RS13935	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
B1756_RS13975	COG3971	2-oxopent-4-enoate hydratase activity
B1756_RS13980	COG3971	2-oxopent-4-enoate hydratase activity
B1756_RS13985	COG0346	lactoylglutathione lyase activity
B1756_RS13990	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B1756_RS13995	COG4569	acetaldehyde dehydrogenase (acetylating) activity
B1756_RS14010	COG1414	Transcriptional regulator
B1756_RS14020	COG1414	Transcriptional regulator
B1756_RS14045	COG3385	transposase activity
B1756_RS14090	COG1113	amino acid transport
B1756_RS14100	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B1756_RS14105	COG0318	PFAM AMP-dependent synthetase and ligase
B1756_RS14110	COG1960	acyl-CoA dehydrogenase activity
B1756_RS14115	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
B1756_RS14125	COG0183	Belongs to the thiolase family
B1756_RS14150	COG1082	Xylose isomerase domain protein TIM barrel
B1756_RS14155	COG1078	dGTPase activity
B1756_RS14185	COG0101	tRNA pseudouridine synthase activity
B1756_RS14200	COG0346	lactoylglutathione lyase activity
B1756_RS14205	COG0393	Putative heavy-metal-binding
B1756_RS14290	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
B1756_RS14295	COG1748	Saccharopine dehydrogenase
B1756_RS14300	COG0156	8-amino-7-oxononanoate synthase activity
B1756_RS14415	COG0509	glycine decarboxylation via glycine cleavage system
B1756_RS14420	COG0404	The glycine cleavage system catalyzes the degradation of glycine
B1756_RS14425	COG0277	FAD linked oxidase domain protein
B1756_RS14425	COG0247	lactate metabolic process
B1756_RS14470	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
B1756_RS14475	COG0463	Glycosyl transferase, family 2
B1756_RS14475	COG1216	Glycosyl transferase, family 2
B1756_RS14505	COG0574	Belongs to the PEP-utilizing enzyme family
B1756_RS14505	COG3848	Pyruvate phosphate dikinase
B1756_RS14510	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
B1756_RS14515	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
B1756_RS14520	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
B1756_RS14525	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
B1756_RS14610	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
B1756_RS14615	COG0277	FAD linked oxidase domain protein
B1756_RS14615	COG0247	lactate metabolic process
B1756_RS14620	COG2205	protein histidine kinase activity
B1756_RS14625	COG2205	protein histidine kinase activity
B1756_RS14630	COG0024	Methionine aminopeptidase
B1756_RS14660	COG2312	Erythromycin esterase
B1756_RS14665	COG1132	(ABC) transporter
B1756_RS14680	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
B1756_RS14695	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
B1756_RS14720	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
B1756_RS14730	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B1756_RS14740	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
B1756_RS14750	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
B1756_RS14760	COG1420	regulation of RNA biosynthetic process
B1756_RS14780	COG0105	UTP biosynthetic process
B1756_RS14800	COG1444	tRNA N-acetyltransferase activity
B1756_RS14805	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
B1756_RS14810	COG4221	oxidoreductase activity
B1756_RS14825	COG1793	dna ligase
B1756_RS14860	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
B1756_RS14870	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
B1756_RS14910	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
B1756_RS14950	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
B1756_RS14955	COG1830	Aldolase
B1756_RS14965	COG1250	3-hydroxyacyl-CoA dehydrogenase
B1756_RS14975	COG1960	acyl-CoA dehydrogenase activity
B1756_RS14980	COG1278	Cold shock
B1756_RS14995	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B1756_RS15000	COG0492	ferredoxin-NADP+ reductase activity
B1756_RS15005	COG1120	ATPase activity
B1756_RS15025	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B1756_RS15030	COG0667	Aldo Keto reductase
B1756_RS15050	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B1756_RS15050	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B1756_RS15055	COG1703	isobutyryl-CoA mutase activity
B1756_RS15065	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B1756_RS15095	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
B1756_RS15100	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
B1756_RS15105	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
B1756_RS15110	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B1756_RS15115	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B1756_RS15120	COG0649	NAD binding
B1756_RS15145	COG0713	ATP synthesis coupled electron transport
B1756_RS15160	COG1007	ATP synthesis coupled electron transport
B1756_RS15175	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
B1756_RS15180	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
B1756_RS15190	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B1756_RS15220	COG4555	ABC transporter
B1756_RS15240	COG1858	cytochrome C peroxidase
B1756_RS15250	COG1138	Cytochrome C-type biogenesis protein
B1756_RS15280	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
B1756_RS15305	COG0589	response to stress
B1756_RS15315	COG1253	flavin adenine dinucleotide binding
B1756_RS15320	COG0589	response to stress
B1756_RS15330	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
B1756_RS15335	COG0492	ferredoxin-NADP+ reductase activity
B1756_RS15345	COG3842	ATPase activity
B1756_RS15350	COG1176	ABC-type spermidine putrescine transport system, permease component I
B1756_RS15355	COG1177	transmembrane transport
B1756_RS15400	COG0589	response to stress
B1756_RS15415	COG0471	metal ion transport
B1756_RS15415	COG3273	potassium ion transport
B1756_RS15425	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
B1756_RS15430	COG0569	domain protein
B1756_RS15445	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
B1756_RS15455	COG0183	Belongs to the thiolase family
B1756_RS15470	COG0589	response to stress
B1756_RS15480	COG2897	thiosulfate sulfurtransferase activity
B1756_RS15485	COG1252	NADH dehydrogenase
B1756_RS15500	COG0450	alkyl hydroperoxide reductase
B1756_RS15505	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B1756_RS15505	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B1756_RS15520	COG0589	response to stress
B1756_RS15525	COG0446	pyridine nucleotide-disulphide oxidoreductase
B1756_RS15535	COG1271	oxidase subunit
B1756_RS15545	COG0589	response to stress
B1756_RS15555	COG0277	FAD linked oxidase domain protein
B1756_RS15560	COG2610	gluconate transmembrane transporter activity
B1756_RS15585	COG1414	Transcriptional regulator
B1756_RS15595	COG1139	Iron-sulfur cluster binding protein
B1756_RS15605	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
B1756_RS15615	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
B1756_RS15640	COG4948	Mandelate Racemase Muconate Lactonizing
B1756_RS15645	COG3119	arylsulfatase activity
B1756_RS15655	COG2226	methyltransferase
B1756_RS15680	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
B1756_RS15685	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
B1756_RS15770	COG0589	response to stress
B1756_RS15780	COG3118	belongs to the thioredoxin family
B1756_RS15810	COG0425	Belongs to the sulfur carrier protein TusA family
B1756_RS15815	COG2210	Belongs to the sulfur carrier protein TusA family
B1756_RS15825	COG0446	pyridine nucleotide-disulphide oxidoreductase
B1756_RS15850	COG0714	Associated with various cellular activities
B1756_RS15855	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B1756_RS15865	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B1756_RS15870	COG3971	2-oxopent-4-enoate hydratase activity
B1756_RS15900	COG0346	lactoylglutathione lyase activity
B1756_RS15905	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B1756_RS15910	COG4569	acetaldehyde dehydrogenase (acetylating) activity
B1756_RS15930	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
B1756_RS15940	COG0318	PFAM AMP-dependent synthetase and ligase
B1756_RS15995	COG0584	glycerophosphoryl diester phosphodiesterase
B1756_RS16000	COG0784	Response regulator, receiver
B1756_RS16005	COG1028	Short-chain dehydrogenase reductase Sdr
B1756_RS16015	COG0174	glutamine synthetase
B1756_RS16050	COG4191	Histidine kinase
B1756_RS16080	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
B1756_RS16115	COG2135	peptidase activity
B1756_RS16125	COG0251	oxidation-reduction process
B1756_RS16150	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
B1756_RS16155	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
B1756_RS16180	COG2252	PERMEase
B1756_RS16185	COG0569	domain protein
B1756_RS16190	COG0589	response to stress
B1756_RS16195	COG0318	PFAM AMP-dependent synthetase and ligase
B1756_RS16200	COG1024	Enoyl-CoA hydratase
B1756_RS16285	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B1756_RS16295	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
B1756_RS16305	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
B1756_RS16310	COG1028	Short-chain dehydrogenase reductase Sdr
B1756_RS16320	COG0471	metal ion transport
B1756_RS16330	COG0589	response to stress
B1756_RS16335	COG0003	Pfam Anion-transporting ATPase
B1756_RS16345	COG1546	Belongs to the CinA family
B1756_RS16345	COG1058	Belongs to the CinA family
B1756_RS16425	COG0484	heat shock protein binding
B1756_RS16430	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B1756_RS16475	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
B1756_RS16495	COG0483	inositol monophosphate 1-phosphatase activity
B1756_RS16515	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
B1756_RS16530	COG1024	Enoyl-CoA hydratase
B1756_RS16545	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
B1756_RS16550	COG0126	phosphoglycerate kinase activity
B1756_RS16575	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
B1756_RS16580	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
B1756_RS16595	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
B1756_RS16600	COG2759	Belongs to the formate--tetrahydrofolate ligase family
B1756_RS16605	COG3383	formate dehydrogenase (NAD+) activity
B1756_RS16610	COG0251	oxidation-reduction process
B1756_RS16615	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
B1756_RS16620	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
B1756_RS16635	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
B1756_RS16645	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
B1756_RS16650	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
B1756_RS16655	COG0404	The glycine cleavage system catalyzes the degradation of glycine
B1756_RS16665	COG1045	serine acetyltransferase
B1756_RS16695	COG1012	belongs to the aldehyde dehydrogenase family
B1756_RS16740	COG1028	Short-chain dehydrogenase reductase Sdr
B1756_RS16760	COG2807	transmembrane transport
B1756_RS16780	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
B1756_RS16810	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
B1756_RS16825	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B1756_RS16830	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
B1756_RS16875	COG0702	epimerase
B1756_RS16895	COG0546	phosphoglycolate phosphatase activity
B1756_RS16910	COG0475	glutathione-regulated potassium exporter activity
B1756_RS16915	COG4651	solute:proton antiporter activity
B1756_RS16915	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
B1756_RS16955	COG2096	Adenosyltransferase
B1756_RS16990	COG3385	transposase activity
B1756_RS17010	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
B1756_RS17030	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
B1756_RS17040	COG1832	CoA-binding protein
B1756_RS17060	COG2133	pyrroloquinoline quinone binding
B1756_RS17105	COG0134	indole-3-glycerol-phosphate synthase activity
B1756_RS17110	COG0133	tryptophan synthase activity
B1756_RS17115	COG0159	tryptophan synthase activity
B1756_RS17135	COG0585	pseudouridine synthase activity
B1756_RS17150	COG1366	Belongs to the anti-sigma-factor antagonist family
B1756_RS17195	COG3639	organic phosphonate transmembrane transporter activity
B1756_RS17225	COG0704	Plays a role in the regulation of phosphate uptake
B1756_RS17235	COG0581	inorganic phosphate transmembrane transporter activity
B1756_RS17240	COG0573	inorganic phosphate transmembrane transporter activity
B1756_RS17280	COG0189	ligase activity
B1756_RS17285	COG2244	polysaccharide biosynthetic process
B1756_RS17295	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B1756_RS17295	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B1756_RS17330	COG0484	heat shock protein binding
B1756_RS17340	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
B1756_RS17345	COG0573	inorganic phosphate transmembrane transporter activity
B1756_RS17350	COG0581	inorganic phosphate transmembrane transporter activity
B1756_RS17355	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
B1756_RS17365	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B1756_RS17370	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B1756_RS17375	COG0628	permease
B1756_RS17415	COG1522	sequence-specific DNA binding
B1756_RS17435	COG1013	pyruvate-flavodoxin oxidoreductase activity
B1756_RS17455	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
B1756_RS17470	COG3118	belongs to the thioredoxin family
B1756_RS17490	COG0318	PFAM AMP-dependent synthetase and ligase
B1756_RS17500	COG0006	proline dipeptidase activity
B1756_RS17505	COG2873	o-acetylhomoserine
B1756_RS17540	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
B1756_RS17545	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
B1756_RS17550	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
B1756_RS17560	COG4948	Mandelate Racemase Muconate Lactonizing
B1756_RS17615	COG0589	response to stress
B1756_RS17625	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B1756_RS17625	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B1756_RS17635	COG2239	Acts as a magnesium transporter
B1756_RS17640	COG1227	inorganic diphosphatase activity
B1756_RS17645	COG1058	Belongs to the CinA family
B1756_RS17645	COG1546	Belongs to the CinA family
B1756_RS17650	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
B1756_RS17655	COG1763	Mo-molybdopterin cofactor biosynthetic process
B1756_RS17670	COG5002	protein histidine kinase activity
B1756_RS17680	COG1733	regulation of RNA biosynthetic process
B1756_RS17695	COG1024	Enoyl-CoA hydratase
B1756_RS17710	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
B1756_RS17715	COG0540	Belongs to the ATCase OTCase family
B1756_RS17730	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
B1756_RS17750	COG1940	carbohydrate kinase activity
B1756_RS17770	COG0460	homoserine dehydrogenase
B1756_RS17780	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
B1756_RS17785	COG0051	transcription antitermination factor activity, RNA binding
B1756_RS17945	COG1074	ATP-dependent DNA helicase activity
B1756_RS17950	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
B1756_RS17960	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
B1756_RS17975	COG1252	NADH dehydrogenase
B1756_RS18010	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B1756_RS18035	COG1914	H( )-stimulated, divalent metal cation uptake system
B1756_RS18040	COG1028	Short-chain dehydrogenase reductase Sdr
B1756_RS18045	COG0435	Glutathione S-transferase
B1756_RS18075	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
B1756_RS18080	COG1111	helicase
B1756_RS18080	COG1205	dead DEAH box helicase
B1756_RS18100	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
B1756_RS18105	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
B1756_RS18110	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
B1756_RS18115	COG3290	protein histidine kinase activity
B1756_RS18115	COG0840	transmembrane signaling receptor activity
B1756_RS18120	COG1331	Highly conserved protein containing a thioredoxin domain
B1756_RS18140	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
B1756_RS18150	COG0301	tRNA thio-modification
B1756_RS18155	COG0840	transmembrane signaling receptor activity
B1756_RS18160	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
B1756_RS18170	COG1047	Peptidyl-prolyl cis-trans
B1756_RS18220	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B1756_RS18225	COG0745	RESPONSE REGULATOR receiver
B1756_RS18235	COG0436	Aminotransferase
B1756_RS18260	COG0434	BtpA family
B1756_RS18310	COG1139	Iron-sulfur cluster binding protein
B1756_RS18355	COG2205	protein histidine kinase activity
B1756_RS18370	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
B1756_RS18390	COG2226	methyltransferase
B1756_RS18395	COG2226	methyltransferase
B1756_RS18400	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
B1756_RS18405	COG0602	queuosine metabolic process
B1756_RS18420	COG1058	Belongs to the CinA family
B1756_RS18420	COG1546	Belongs to the CinA family
B1756_RS18440	COG0436	Aminotransferase
B1756_RS18465	COG1012	belongs to the aldehyde dehydrogenase family
B1756_RS18480	COG1960	acyl-CoA dehydrogenase activity
B1756_RS18490	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
B1756_RS18495	COG2301	Belongs to the HpcH HpaI aldolase family
B1756_RS18500	COG2030	dehydratase
B1756_RS18520	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B1756_RS18530	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B1756_RS18535	COG0154	amidase activity
B1756_RS18555	COG0318	PFAM AMP-dependent synthetase and ligase
B1756_RS18560	COG4948	Mandelate Racemase Muconate Lactonizing
B1756_RS18565	COG1575	Belongs to the MenA family. Type 1 subfamily
B1756_RS18595	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
B1756_RS18600	COG0484	heat shock protein binding
B1756_RS18605	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
B1756_RS18640	COG0107	imidazoleglycerol-phosphate synthase activity
B1756_RS18670	COG1136	(ABC) transporter
B1756_RS18670	COG0577	efflux transmembrane transporter activity
B1756_RS18690	COG2264	protein methyltransferase activity
B1756_RS18745	COG4974	Belongs to the 'phage' integrase family
B1756_RS18765	COG0114	fumarate hydratase activity
B1756_RS18795	COG0215	cysteine-tRNA ligase activity
B1756_RS18885	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B1756_RS18890	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B1756_RS18895	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
B1756_RS18925	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
B1756_RS18995	COG2199	diguanylate cyclase activity
B1756_RS18995	COG2202	Pas domain
B1756_RS18995	COG2200	EAL domain