locus-tag	class	description
AArc1_RS00020	COG1192	Involved in chromosome partitioning
AArc1_RS00050	COG1111	helicase
AArc1_RS00050	COG1205	dead DEAH box helicase
AArc1_RS00060	COG1205	dead DEAH box helicase
AArc1_RS00060	COG1111	helicase
AArc1_RS00075	COG0210	DNA helicase
AArc1_RS00180	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AArc1_RS00340	COG1401	restriction endodeoxyribonuclease activity
AArc1_RS00410	COG0280	phosphate acetyltransferase
AArc1_RS00410	COG0281	malic enzyme
AArc1_RS00415	COG5002	protein histidine kinase activity
AArc1_RS00460	COG1192	Involved in chromosome partitioning
AArc1_RS00470	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AArc1_RS00495	COG0410	ABC transporter
AArc1_RS00505	COG0577	efflux transmembrane transporter activity
AArc1_RS00505	COG1136	(ABC) transporter
AArc1_RS00510	COG1136	(ABC) transporter
AArc1_RS00535	COG3938	Belongs to the proline racemase family
AArc1_RS00540	COG2217	Heavy metal translocating P-type atpase
AArc1_RS00555	COG3268	Saccharopine dehydrogenase
AArc1_RS00630	COG0385	Bile acid
AArc1_RS00635	COG0277	FAD linked oxidase domain protein
AArc1_RS00665	COG1414	Transcriptional regulator
AArc1_RS00675	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AArc1_RS00680	COG0318	PFAM AMP-dependent synthetase and ligase
AArc1_RS00685	COG1960	acyl-CoA dehydrogenase activity
AArc1_RS00690	COG0183	Belongs to the thiolase family
AArc1_RS00695	COG1250	3-hydroxyacyl-CoA dehydrogenase
AArc1_RS00700	COG1024	Enoyl-CoA hydratase
AArc1_RS00735	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
AArc1_RS00740	COG2205	protein histidine kinase activity
AArc1_RS00745	COG5002	protein histidine kinase activity
AArc1_RS00785	COG1414	Transcriptional regulator
AArc1_RS00875	COG1131	(ABC) transporter
AArc1_RS00880	COG0501	Belongs to the peptidase M48B family
AArc1_RS00900	COG3290	protein histidine kinase activity
AArc1_RS00915	COG1028	Short-chain dehydrogenase reductase Sdr
AArc1_RS00930	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AArc1_RS00965	COG0375	protein maturation
AArc1_RS00970	COG0309	Hydrogenase expression formation protein (HypE)
AArc1_RS01000	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
AArc1_RS01010	COG1120	ATPase activity
AArc1_RS01015	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AArc1_RS01045	COG0733	neurotransmitter:sodium symporter activity
AArc1_RS01120	COG0719	Fe-S assembly protein
AArc1_RS01165	COG0527	aspartate kinase activity
AArc1_RS01170	COG0318	PFAM AMP-dependent synthetase and ligase
AArc1_RS01175	COG3033	Beta-eliminating lyase
AArc1_RS01205	COG0577	efflux transmembrane transporter activity
AArc1_RS01210	COG1136	(ABC) transporter
AArc1_RS01215	COG1024	Enoyl-CoA hydratase
AArc1_RS01220	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AArc1_RS01230	COG1304	FMN binding
AArc1_RS01240	COG1691	(AIR) carboxylase
AArc1_RS01245	COG2827	Endonuclease containing a URI domain
AArc1_RS01260	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AArc1_RS01270	COG0501	Belongs to the peptidase M48B family
AArc1_RS01275	COG1045	serine acetyltransferase
AArc1_RS01300	COG1902	pentaerythritol trinitrate reductase activity
AArc1_RS01350	COG0039	L-malate dehydrogenase activity
AArc1_RS01370	COG3011	Protein conserved in bacteria
AArc1_RS01380	COG0556	nucleotide-excision repair
AArc1_RS01385	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AArc1_RS01420	COG0423	glycine-tRNA ligase activity
AArc1_RS01425	COG4109	DRTGG domain
AArc1_RS01440	COG4608	Belongs to the ABC transporter superfamily
AArc1_RS01445	COG0444	Belongs to the ABC transporter superfamily
AArc1_RS01450	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AArc1_RS01455	COG0601	transmembrane transport
AArc1_RS01480	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AArc1_RS01515	COG1648	precorrin-2 dehydrogenase activity
AArc1_RS01515	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AArc1_RS01520	COG0181	hydroxymethylbilane synthase activity
AArc1_RS01530	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AArc1_RS01535	COG0004	ammonium transporteR
AArc1_RS01545	COG0113	porphobilinogen synthase activity
AArc1_RS01555	COG0348	domain, Protein
AArc1_RS01570	COG1064	alcohol dehydrogenase
AArc1_RS01590	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AArc1_RS01625	COG0501	Belongs to the peptidase M48B family
AArc1_RS01645	COG2267	carboxylic ester hydrolase activity
AArc1_RS01660	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AArc1_RS01665	COG1131	(ABC) transporter
AArc1_RS01700	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
AArc1_RS01710	COG0805	protein transport
AArc1_RS01715	COG0805	protein transport
AArc1_RS01725	COG1606	tRNA processing
AArc1_RS01755	COG0523	cobalamin synthesis protein
AArc1_RS01760	COG0523	cobalamin synthesis protein
AArc1_RS01765	COG0521	Mo-molybdopterin cofactor biosynthetic process
AArc1_RS01825	COG0671	phosphoesterase, PA-phosphatase related
AArc1_RS01850	COG1132	(ABC) transporter
AArc1_RS01975	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AArc1_RS01995	COG4221	oxidoreductase activity
AArc1_RS02015	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AArc1_RS02080	COG2226	methyltransferase
AArc1_RS02100	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AArc1_RS02110	COG0723	plastoquinol--plastocyanin reductase activity
AArc1_RS02110	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AArc1_RS02140	COG0589	response to stress
AArc1_RS02150	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
AArc1_RS02175	COG0009	L-threonylcarbamoyladenylate synthase
AArc1_RS02205	COG0589	response to stress
AArc1_RS02235	COG0456	acetyltransferase
AArc1_RS02245	COG0464	growth
AArc1_RS02275	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
AArc1_RS02280	COG3639	organic phosphonate transmembrane transporter activity
AArc1_RS02305	COG1175	transmembrane transport
AArc1_RS02310	COG0395	ABC-type sugar transport system, permease component
AArc1_RS02315	COG3842	ATPase activity
AArc1_RS02340	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AArc1_RS02345	COG0573	inorganic phosphate transmembrane transporter activity
AArc1_RS02350	COG0581	inorganic phosphate transmembrane transporter activity
AArc1_RS02360	COG0704	Plays a role in the regulation of phosphate uptake
AArc1_RS02390	COG1185	polyribonucleotide nucleotidyltransferase activity
AArc1_RS02405	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AArc1_RS02425	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AArc1_RS02425	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AArc1_RS02455	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AArc1_RS02470	COG1573	uracil-dna glycosylase
AArc1_RS02530	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AArc1_RS02550	COG0714	Associated with various cellular activities
AArc1_RS02555	COG1278	Cold shock
AArc1_RS02575	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
AArc1_RS02575	COG0778	Nitroreductase
AArc1_RS02580	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AArc1_RS02600	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AArc1_RS02615	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AArc1_RS02665	COG0765	amino acid transport
AArc1_RS02670	COG1126	abc transporter atp-binding protein
AArc1_RS02675	COG0765	amino acid transport
AArc1_RS02685	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AArc1_RS02690	COG4946	Tricorn protease homolog
AArc1_RS02690	COG0823	Involved in the tonB-independent uptake of proteins
AArc1_RS02690	COG1506	peptidase
AArc1_RS02710	COG0475	glutathione-regulated potassium exporter activity
AArc1_RS02710	COG0589	response to stress
AArc1_RS02720	COG0116	Belongs to the methyltransferase superfamily
AArc1_RS02720	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AArc1_RS02730	COG1607	acyl-coa hydrolase
AArc1_RS02740	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AArc1_RS02745	COG3639	organic phosphonate transmembrane transporter activity
AArc1_RS02750	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
AArc1_RS02760	COG1078	dGTPase activity
AArc1_RS02770	COG1234	tRNA 3'-trailer cleavage
AArc1_RS02775	COG2205	protein histidine kinase activity
AArc1_RS02810	COG0697	spore germination
AArc1_RS02825	COG2873	o-acetylhomoserine
AArc1_RS02830	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AArc1_RS02850	COG0560	Phosphoserine phosphatase
AArc1_RS02900	COG3842	ATPase activity
AArc1_RS02905	COG0395	ABC-type sugar transport system, permease component
AArc1_RS02910	COG1175	transmembrane transport
AArc1_RS02920	COG1285	pathogenesis
AArc1_RS02925	COG0647	UMP catabolic process
AArc1_RS02965	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AArc1_RS02975	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AArc1_RS02995	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AArc1_RS03000	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AArc1_RS03005	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AArc1_RS03015	COG0131	Imidazoleglycerol-phosphate dehydratase
AArc1_RS03040	COG1739	Uncharacterized protein family UPF0029
AArc1_RS03060	COG3119	arylsulfatase activity
AArc1_RS03085	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AArc1_RS03100	COG0314	molybdopterin synthase activity
AArc1_RS03105	COG0528	UMP kinase activity
AArc1_RS03125	COG3253	May function as heme-dependent peroxidase
AArc1_RS03185	COG2894	cell division
AArc1_RS03225	COG0385	Bile acid
AArc1_RS03230	COG0494	nUDIX hydrolase
AArc1_RS03240	COG2339	peptidase activity
AArc1_RS03255	COG0210	DNA helicase
AArc1_RS03265	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AArc1_RS03275	COG0714	Associated with various cellular activities
AArc1_RS03320	COG0142	geranyltranstransferase activity
AArc1_RS03350	COG1063	alcohol dehydrogenase
AArc1_RS03415	COG0318	PFAM AMP-dependent synthetase and ligase
AArc1_RS03460	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AArc1_RS03465	COG1164	Oligoendopeptidase f
AArc1_RS03475	COG2311	Membrane
AArc1_RS03480	COG2133	pyrroloquinoline quinone binding
AArc1_RS03495	COG1234	tRNA 3'-trailer cleavage
AArc1_RS03520	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AArc1_RS03535	COG1045	serine acetyltransferase
AArc1_RS03545	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AArc1_RS03550	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AArc1_RS03555	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AArc1_RS03565	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AArc1_RS03575	COG0589	response to stress
AArc1_RS03580	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AArc1_RS03585	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AArc1_RS03590	COG0251	oxidation-reduction process
AArc1_RS03595	COG3383	formate dehydrogenase (NAD+) activity
AArc1_RS03605	COG2759	Belongs to the formate--tetrahydrofolate ligase family
AArc1_RS03610	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AArc1_RS03620	COG2086	electron transfer activity
AArc1_RS03625	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AArc1_RS03630	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AArc1_RS03650	COG1063	alcohol dehydrogenase
AArc1_RS03655	COG2205	protein histidine kinase activity
AArc1_RS03665	COG1201	RNA secondary structure unwinding
AArc1_RS03700	COG1250	3-hydroxyacyl-CoA dehydrogenase
AArc1_RS03725	COG1028	Short-chain dehydrogenase reductase Sdr
AArc1_RS03730	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AArc1_RS03805	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
AArc1_RS03820	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AArc1_RS03825	COG0017	Asparaginyl-tRNA synthetase
AArc1_RS03845	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AArc1_RS03850	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
AArc1_RS03850	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
AArc1_RS03855	COG0589	response to stress
AArc1_RS03865	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AArc1_RS03895	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
AArc1_RS03905	COG1959	2 iron, 2 sulfur cluster binding
AArc1_RS03905	COG1295	ribonuclease BN
AArc1_RS03925	COG2135	peptidase activity
AArc1_RS03985	COG0531	amino acid
AArc1_RS03990	COG0531	amino acid
AArc1_RS04015	COG1366	Belongs to the anti-sigma-factor antagonist family
AArc1_RS04015	COG2202	Pas domain
AArc1_RS04045	COG1515	deoxyribonuclease V activity
AArc1_RS04050	COG1028	Short-chain dehydrogenase reductase Sdr
AArc1_RS04075	COG0003	Pfam Anion-transporting ATPase
AArc1_RS04085	COG0436	Aminotransferase
AArc1_RS04095	COG1058	Belongs to the CinA family
AArc1_RS04095	COG1546	Belongs to the CinA family
AArc1_RS04135	COG4191	Histidine kinase
AArc1_RS04180	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AArc1_RS04190	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AArc1_RS04200	COG0303	'Molybdopterin
AArc1_RS04225	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AArc1_RS04225	COG1796	DNA polymerase
AArc1_RS04260	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AArc1_RS04270	COG4948	Mandelate Racemase Muconate Lactonizing
AArc1_RS04275	COG1063	alcohol dehydrogenase
AArc1_RS04280	COG0800	Aldolase
AArc1_RS04285	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AArc1_RS04305	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AArc1_RS04310	COG2030	dehydratase
AArc1_RS04315	COG1960	acyl-CoA dehydrogenase activity
AArc1_RS04325	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AArc1_RS04325	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AArc1_RS04335	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AArc1_RS04335	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AArc1_RS04340	COG0589	response to stress
AArc1_RS04350	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AArc1_RS04360	COG1024	Enoyl-CoA hydratase
AArc1_RS04365	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AArc1_RS04380	COG0183	Belongs to the thiolase family
AArc1_RS04385	COG1250	3-hydroxyacyl-CoA dehydrogenase
AArc1_RS04390	COG1960	acyl-CoA dehydrogenase activity
AArc1_RS04405	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AArc1_RS04410	COG1414	Transcriptional regulator
AArc1_RS04430	COG0483	inositol monophosphate 1-phosphatase activity
AArc1_RS04435	COG0517	IMP dehydrogenase activity
AArc1_RS04445	COG2154	pterin-4-alpha-carbinolamine dehydratase
AArc1_RS04455	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AArc1_RS04470	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AArc1_RS04475	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AArc1_RS04490	COG0358	DNA primase activity
AArc1_RS04530	COG0525	valine-tRNA ligase activity
AArc1_RS04540	COG4347	Protein of unknown function (DUF1405)
AArc1_RS04550	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
AArc1_RS04555	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AArc1_RS04570	COG0083	homoserine kinase activity
AArc1_RS04610	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
AArc1_RS04615	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AArc1_RS04630	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AArc1_RS04655	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AArc1_RS04675	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AArc1_RS04690	COG1028	Short-chain dehydrogenase reductase Sdr
AArc1_RS04700	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AArc1_RS04705	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AArc1_RS04710	COG3976	FMN-binding domain protein
AArc1_RS04710	COG1053	succinate dehydrogenase
AArc1_RS04715	COG0430	RNA-3'-phosphate cyclase activity
AArc1_RS04725	COG0557	exoribonuclease II activity
AArc1_RS04750	COG0492	ferredoxin-NADP+ reductase activity
AArc1_RS04760	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AArc1_RS04765	COG0601	transmembrane transport
AArc1_RS04795	COG2814	Major facilitator Superfamily
AArc1_RS04820	COG0372	Belongs to the citrate synthase family
AArc1_RS04840	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AArc1_RS04845	COG0251	oxidation-reduction process
AArc1_RS04925	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AArc1_RS04970	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
AArc1_RS05000	COG2897	thiosulfate sulfurtransferase activity
AArc1_RS05030	COG0247	lactate metabolic process
AArc1_RS05040	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AArc1_RS05045	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AArc1_RS05080	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AArc1_RS05110	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AArc1_RS05125	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AArc1_RS05135	COG1473	amidohydrolase
AArc1_RS05145	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AArc1_RS05150	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AArc1_RS05160	COG1473	amidohydrolase
AArc1_RS05175	COG0006	proline dipeptidase activity
AArc1_RS05190	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AArc1_RS05200	COG1720	tRNA m6t6A37 methyltransferase activity
AArc1_RS05210	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AArc1_RS05220	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AArc1_RS05245	COG1562	ergosterol biosynthetic process
AArc1_RS05265	COG1233	COG1233 Phytoene dehydrogenase and related
AArc1_RS05330	COG1216	Glycosyl transferase, family 2
AArc1_RS05365	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AArc1_RS05385	COG0037	tRNA processing
AArc1_RS05410	COG4106	trans-aconitate 2-methyltransferase activity
AArc1_RS05425	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
AArc1_RS05430	COG0095	Lipoate-protein ligase
AArc1_RS05440	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AArc1_RS05450	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AArc1_RS05465	COG0798	PFAM Bile acid sodium symporter
AArc1_RS05525	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AArc1_RS05530	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AArc1_RS05540	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AArc1_RS05580	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AArc1_RS05635	COG3842	ATPase activity
AArc1_RS05640	COG4208	sulfate ABC transporter
AArc1_RS05655	COG1414	Transcriptional regulator
AArc1_RS05660	COG1960	acyl-CoA dehydrogenase activity
AArc1_RS05665	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AArc1_RS05680	COG2358	TRAP transporter, solute receptor (TAXI family
AArc1_RS05710	COG0101	tRNA pseudouridine synthase activity
AArc1_RS05720	COG1957	nucleoside hydrolase
AArc1_RS05735	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AArc1_RS05785	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AArc1_RS05785	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AArc1_RS05790	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AArc1_RS05800	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
AArc1_RS05830	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AArc1_RS05845	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AArc1_RS05860	COG1966	Carbon starvation protein
AArc1_RS05865	COG0003	Pfam Anion-transporting ATPase
AArc1_RS05875	COG0523	cobalamin synthesis protein
AArc1_RS05910	COG1960	acyl-CoA dehydrogenase activity
AArc1_RS05920	COG0183	Belongs to the thiolase family
AArc1_RS05925	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AArc1_RS05935	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AArc1_RS05940	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AArc1_RS05950	COG0179	Fumarylacetoacetate (FAA) hydrolase
AArc1_RS05960	COG1028	Short-chain dehydrogenase reductase Sdr
AArc1_RS05965	COG1522	sequence-specific DNA binding
AArc1_RS05970	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AArc1_RS05975	COG1012	belongs to the aldehyde dehydrogenase family
AArc1_RS05995	COG1078	dGTPase activity
AArc1_RS06005	COG2897	thiosulfate sulfurtransferase activity
AArc1_RS06010	COG0446	pyridine nucleotide-disulphide oxidoreductase
AArc1_RS06020	COG0450	alkyl hydroperoxide reductase
AArc1_RS06030	COG0492	ferredoxin-NADP+ reductase activity
AArc1_RS06035	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AArc1_RS06035	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AArc1_RS06050	COG0531	amino acid
AArc1_RS06055	COG0589	response to stress
AArc1_RS06060	COG0446	pyridine nucleotide-disulphide oxidoreductase
AArc1_RS06070	COG1271	oxidase subunit
AArc1_RS06085	COG0673	inositol 2-dehydrogenase activity
AArc1_RS06090	COG1082	Xylose isomerase domain protein TIM barrel
AArc1_RS06100	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AArc1_RS06125	COG0668	transmembrane transport
AArc1_RS06130	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AArc1_RS06155	COG0626	cystathionine gamma-synthase activity
AArc1_RS06175	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AArc1_RS06240	COG0446	pyridine nucleotide-disulphide oxidoreductase
AArc1_RS06245	COG2210	Belongs to the sulfur carrier protein TusA family
AArc1_RS06250	COG0425	Belongs to the sulfur carrier protein TusA family
AArc1_RS06255	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AArc1_RS06255	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AArc1_RS06285	COG0243	molybdopterin cofactor binding
AArc1_RS06290	COG0437	4 iron, 4 sulfur cluster binding
AArc1_RS06310	COG3118	belongs to the thioredoxin family
AArc1_RS06320	COG0589	response to stress
AArc1_RS06390	COG1012	belongs to the aldehyde dehydrogenase family
AArc1_RS06400	COG3119	arylsulfatase activity
AArc1_RS06440	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AArc1_RS06470	COG0589	response to stress
AArc1_RS06490	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
AArc1_RS06505	COG0589	response to stress
AArc1_RS06565	COG1858	cytochrome C peroxidase
AArc1_RS06575	COG1138	Cytochrome C-type biogenesis protein
AArc1_RS06590	COG4555	ABC transporter
AArc1_RS06605	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
AArc1_RS06620	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AArc1_RS06630	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AArc1_RS06635	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AArc1_RS06645	COG2226	methyltransferase
AArc1_RS06720	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AArc1_RS06740	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AArc1_RS06805	COG4974	Belongs to the 'phage' integrase family
AArc1_RS06900	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AArc1_RS06910	COG0105	UTP biosynthetic process
AArc1_RS06930	COG1444	tRNA N-acetyltransferase activity
AArc1_RS06935	COG4221	oxidoreductase activity
AArc1_RS06965	COG1192	Involved in chromosome partitioning
AArc1_RS06970	COG2201	protein-glutamate methylesterase activity
AArc1_RS06975	COG0643	Histidine kinase
AArc1_RS06975	COG2198	Histidine kinase
AArc1_RS06990	COG0688	phosphatidylethanolamine metabolic process
AArc1_RS06995	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AArc1_RS07020	COG1605	Chorismate mutase
AArc1_RS07020	COG0287	Prephenate dehydrogenase
AArc1_RS07025	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AArc1_RS07030	COG0142	geranyltranstransferase activity
AArc1_RS07040	COG0531	amino acid
AArc1_RS07055	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AArc1_RS07075	COG2201	protein-glutamate methylesterase activity
AArc1_RS07090	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AArc1_RS07100	COG1757	Na H antiporter
AArc1_RS07105	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AArc1_RS07125	COG2252	PERMEase
AArc1_RS07140	COG0435	Glutathione S-transferase
AArc1_RS07220	COG0179	Fumarylacetoacetate (FAA) hydrolase
AArc1_RS07250	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AArc1_RS07275	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AArc1_RS07335	COG0509	glycine decarboxylation via glycine cleavage system
AArc1_RS07340	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AArc1_RS07390	COG0628	permease
AArc1_RS07395	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AArc1_RS07400	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AArc1_RS07415	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AArc1_RS07425	COG0573	inorganic phosphate transmembrane transporter activity
AArc1_RS07430	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AArc1_RS07465	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AArc1_RS07470	COG0088	Forms part of the polypeptide exit tunnel
AArc1_RS07475	COG0089	rRNA binding
AArc1_RS07485	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AArc1_RS07495	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AArc1_RS07500	COG0255	Belongs to the universal ribosomal protein uL29 family
AArc1_RS07510	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AArc1_RS07515	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AArc1_RS07530	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AArc1_RS07540	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AArc1_RS07565	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AArc1_RS07575	COG0200	Binds to the 23S rRNA
AArc1_RS07595	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AArc1_RS07610	COG0563	adenylate kinase activity
AArc1_RS07620	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AArc1_RS07625	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AArc1_RS07660	COG0110	maltose O-acetyltransferase activity
AArc1_RS07665	COG1252	NADH dehydrogenase
AArc1_RS07690	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AArc1_RS07695	COG0187	DNA topoisomerase II activity
AArc1_RS07715	COG0475	glutathione-regulated potassium exporter activity
AArc1_RS07715	COG0589	response to stress
AArc1_RS07720	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AArc1_RS07735	COG0531	amino acid
AArc1_RS07750	COG0483	inositol monophosphate 1-phosphatase activity
AArc1_RS07755	COG2205	protein histidine kinase activity
AArc1_RS07905	COG2096	Adenosyltransferase
AArc1_RS07975	COG0463	Glycosyl transferase, family 2
AArc1_RS07980	COG0463	Glycosyl transferase, family 2
AArc1_RS07985	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AArc1_RS08020	COG1132	(ABC) transporter
AArc1_RS08045	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
AArc1_RS08050	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AArc1_RS08070	COG4608	Belongs to the ABC transporter superfamily
AArc1_RS08075	COG0444	Belongs to the ABC transporter superfamily
AArc1_RS08080	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AArc1_RS08085	COG0601	transmembrane transport
AArc1_RS08090	COG4166	transmembrane transport
AArc1_RS08130	COG4651	solute:proton antiporter activity
AArc1_RS08130	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AArc1_RS08140	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AArc1_RS08140	COG4651	solute:proton antiporter activity
AArc1_RS08145	COG0475	glutathione-regulated potassium exporter activity
AArc1_RS08160	COG0284	orotidine-5'-phosphate decarboxylase activity
AArc1_RS08185	COG0071	Belongs to the small heat shock protein (HSP20) family
AArc1_RS08220	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AArc1_RS08220	COG1213	nucleotidyl transferase
AArc1_RS08230	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AArc1_RS08235	COG1793	dna ligase
AArc1_RS08245	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AArc1_RS08260	COG1185	polyribonucleotide nucleotidyltransferase activity
AArc1_RS08270	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AArc1_RS08270	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AArc1_RS08280	COG0129	dihydroxy-acid dehydratase activity
AArc1_RS08295	COG0243	molybdopterin cofactor binding
AArc1_RS08300	COG0437	4 iron, 4 sulfur cluster binding
AArc1_RS08345	COG0437	4 iron, 4 sulfur cluster binding
AArc1_RS08350	COG3383	formate dehydrogenase (NAD+) activity
AArc1_RS08355	COG0746	molybdenum cofactor guanylyltransferase activity
AArc1_RS08400	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AArc1_RS08405	COG0484	heat shock protein binding
AArc1_RS08480	COG1254	Belongs to the acylphosphatase family
AArc1_RS08490	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AArc1_RS08490	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AArc1_RS08495	COG0315	cyclic pyranopterin monophosphate synthase activity
AArc1_RS08500	COG1028	Short-chain dehydrogenase reductase Sdr
AArc1_RS08505	COG3243	poly(R)-hydroxyalkanoic acid synthase
AArc1_RS08530	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AArc1_RS08570	COG0280	phosphate acetyltransferase
AArc1_RS08570	COG0281	malic enzyme
AArc1_RS08580	COG3252	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT
AArc1_RS08595	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AArc1_RS08600	COG0415	Belongs to the DNA photolyase family
AArc1_RS08605	COG3046	protein related to deoxyribodipyrimidine photolyase
AArc1_RS08625	COG0330	HflC and HflK could
AArc1_RS08645	COG0517	IMP dehydrogenase activity
AArc1_RS08645	COG0516	GMP reductase activity
AArc1_RS08675	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AArc1_RS08695	COG0175	sulfate reduction
AArc1_RS08745	COG2203	Gaf domain
AArc1_RS08745	COG0840	transmembrane signaling receptor activity
AArc1_RS08755	COG1028	Short-chain dehydrogenase reductase Sdr
AArc1_RS08760	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AArc1_RS08765	COG0443	Heat shock 70 kDa protein
AArc1_RS08840	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AArc1_RS08860	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AArc1_RS08865	COG0778	Nitroreductase
AArc1_RS08890	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AArc1_RS08920	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AArc1_RS08940	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AArc1_RS08960	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AArc1_RS08970	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AArc1_RS09010	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AArc1_RS09020	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AArc1_RS09025	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AArc1_RS09030	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AArc1_RS09055	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AArc1_RS09070	COG0148	phosphopyruvate hydratase activity
AArc1_RS09075	COG0052	Belongs to the universal ribosomal protein uS2 family
AArc1_RS09080	COG1280	lysine exporter protein (LysE YggA)
AArc1_RS09105	COG0277	FAD linked oxidase domain protein
AArc1_RS09125	COG0436	Aminotransferase
AArc1_RS09145	COG0644	oxidoreductase
AArc1_RS09150	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AArc1_RS09155	COG2086	electron transfer activity
AArc1_RS09160	COG0489	protein tyrosine kinase activity
AArc1_RS09180	COG1013	pyruvate-flavodoxin oxidoreductase activity
AArc1_RS09185	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AArc1_RS09185	COG0674	pyruvate-flavodoxin oxidoreductase activity
AArc1_RS09195	COG0704	Plays a role in the regulation of phosphate uptake
AArc1_RS09205	COG0644	oxidoreductase
AArc1_RS09215	COG2086	electron transfer activity
AArc1_RS09245	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AArc1_RS09250	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AArc1_RS09260	COG0437	4 iron, 4 sulfur cluster binding
AArc1_RS09270	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AArc1_RS09310	COG2871	sodium ion transport
AArc1_RS09340	COG0346	lactoylglutathione lyase activity
AArc1_RS09350	COG0656	L-ascorbic acid biosynthetic process
AArc1_RS09355	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AArc1_RS09355	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AArc1_RS09385	COG0484	heat shock protein binding
AArc1_RS09400	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AArc1_RS09405	COG0135	phosphoribosylanthranilate isomerase activity
AArc1_RS09410	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AArc1_RS09415	COG0512	Glutamine amidotransferase of anthranilate synthase
AArc1_RS09415	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AArc1_RS09495	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AArc1_RS09515	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
AArc1_RS09520	COG1335	isochorismatase
AArc1_RS09540	COG0405	Gamma-glutamyltransferase
AArc1_RS09615	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AArc1_RS09620	COG0644	oxidoreductase
AArc1_RS09650	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AArc1_RS09655	COG0316	Belongs to the HesB IscA family
AArc1_RS09665	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AArc1_RS09690	COG0668	transmembrane transport
AArc1_RS09700	COG0673	inositol 2-dehydrogenase activity
AArc1_RS09710	COG0415	Belongs to the DNA photolyase family
AArc1_RS09715	COG0671	phosphoesterase, PA-phosphatase related
AArc1_RS09725	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AArc1_RS09745	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AArc1_RS09750	COG0542	response to heat
AArc1_RS09755	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
AArc1_RS09765	COG0697	spore germination
AArc1_RS09775	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AArc1_RS09780	COG1120	ATPase activity
AArc1_RS09785	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AArc1_RS09820	COG0215	cysteine-tRNA ligase activity
AArc1_RS09845	COG0114	fumarate hydratase activity
AArc1_RS09920	COG2264	protein methyltransferase activity
AArc1_RS09935	COG1136	(ABC) transporter
AArc1_RS09935	COG0577	efflux transmembrane transporter activity
AArc1_RS09960	COG0107	imidazoleglycerol-phosphate synthase activity
AArc1_RS09980	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AArc1_RS09985	COG1169	isochorismate synthase
AArc1_RS09990	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AArc1_RS09995	COG0484	heat shock protein binding
AArc1_RS10000	COG2226	methyltransferase
AArc1_RS10010	COG1575	Belongs to the MenA family. Type 1 subfamily
AArc1_RS10015	COG4948	Mandelate Racemase Muconate Lactonizing
AArc1_RS10020	COG0318	PFAM AMP-dependent synthetase and ligase
AArc1_RS10040	COG0154	amidase activity
AArc1_RS10045	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AArc1_RS10055	COG0596	Alpha beta hydrolase
AArc1_RS10065	COG0437	4 iron, 4 sulfur cluster binding
AArc1_RS10085	COG0489	protein tyrosine kinase activity
AArc1_RS10100	COG0587	DNA-directed DNA polymerase activity
AArc1_RS10120	COG0154	amidase activity
AArc1_RS10130	COG0436	Aminotransferase
AArc1_RS10135	COG1522	sequence-specific DNA binding
AArc1_RS10150	COG1902	pentaerythritol trinitrate reductase activity
AArc1_RS10155	COG0434	BtpA family
AArc1_RS10175	COG0081	regulation of translation
AArc1_RS10190	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AArc1_RS10210	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
AArc1_RS10235	COG0647	UMP catabolic process
AArc1_RS10260	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AArc1_RS10265	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
AArc1_RS10275	COG0783	Belongs to the Dps family
AArc1_RS10280	COG1012	belongs to the aldehyde dehydrogenase family
AArc1_RS10315	COG0803	Belongs to the bacterial solute-binding protein 9 family
AArc1_RS10315	COG3443	Belongs to the bacterial solute-binding protein 9 family
AArc1_RS10320	COG1121	(ABC) transporter
AArc1_RS10335	COG0857	belongs to the CobB CobQ family
AArc1_RS10365	COG1546	Belongs to the CinA family
AArc1_RS10365	COG1058	Belongs to the CinA family
AArc1_RS10370	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AArc1_RS10375	COG1763	Mo-molybdopterin cofactor biosynthetic process
AArc1_RS10395	COG1024	Enoyl-CoA hydratase
AArc1_RS10420	COG0540	Belongs to the ATCase OTCase family
AArc1_RS10455	COG1940	carbohydrate kinase activity
AArc1_RS10470	COG0460	homoserine dehydrogenase
AArc1_RS10475	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AArc1_RS10480	COG0051	transcription antitermination factor activity, RNA binding
AArc1_RS10505	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AArc1_RS10555	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AArc1_RS10575	COG3842	ATPase activity
AArc1_RS10650	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AArc1_RS10660	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AArc1_RS10665	COG2234	aminopeptidase activity
AArc1_RS10675	COG1047	Peptidyl-prolyl cis-trans
AArc1_RS10685	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
AArc1_RS10690	COG0301	tRNA thio-modification
AArc1_RS10700	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AArc1_RS10715	COG3852	Histidine kinase
AArc1_RS10725	COG1331	Highly conserved protein containing a thioredoxin domain
AArc1_RS10735	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AArc1_RS10740	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AArc1_RS10745	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AArc1_RS10755	COG1111	helicase
AArc1_RS10755	COG1205	dead DEAH box helicase
AArc1_RS10760	COG0151	Belongs to the GarS family
AArc1_RS10795	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AArc1_RS10800	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AArc1_RS10840	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AArc1_RS10865	COG0824	Thioesterase
AArc1_RS10885	COG0126	phosphoglycerate kinase activity
AArc1_RS10905	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AArc1_RS10910	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AArc1_RS10915	COG4865	methylaspartate mutase activity
AArc1_RS10960	COG0489	protein tyrosine kinase activity
AArc1_RS11040	COG1648	precorrin-2 dehydrogenase activity
AArc1_RS11040	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AArc1_RS11060	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
AArc1_RS11110	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AArc1_RS11120	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AArc1_RS11130	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AArc1_RS11135	COG0589	response to stress
AArc1_RS11150	COG2766	serine protein kinase
AArc1_RS11185	COG0584	glycerophosphoryl diester phosphodiesterase
AArc1_RS11190	COG0784	Response regulator, receiver
AArc1_RS11195	COG1028	Short-chain dehydrogenase reductase Sdr
AArc1_RS11275	COG1131	(ABC) transporter
AArc1_RS11290	COG1522	sequence-specific DNA binding
AArc1_RS11300	COG1013	pyruvate-flavodoxin oxidoreductase activity
AArc1_RS11330	COG0022	dehydrogenase e1 component
AArc1_RS11335	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AArc1_RS11350	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AArc1_RS11365	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AArc1_RS11375	COG0006	proline dipeptidase activity
AArc1_RS11380	COG0784	Response regulator, receiver
AArc1_RS11390	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AArc1_RS11400	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AArc1_RS11405	COG2855	membrane
AArc1_RS11415	COG0573	inorganic phosphate transmembrane transporter activity
AArc1_RS11420	COG0581	inorganic phosphate transmembrane transporter activity
AArc1_RS11425	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AArc1_RS11430	COG0840	transmembrane signaling receptor activity
AArc1_RS11460	COG1506	peptidase
AArc1_RS11490	COG0371	Dehydrogenase
AArc1_RS11520	COG0070	glutamate synthase
AArc1_RS11520	COG0069	glutamate synthase activity
AArc1_RS11520	COG0067	glutamate synthase
AArc1_RS11525	COG0442	prolyl-tRNA aminoacylation
AArc1_RS11535	COG2205	protein histidine kinase activity
AArc1_RS11545	COG1074	ATP-dependent DNA helicase activity
AArc1_RS11560	COG0028	Belongs to the TPP enzyme family
AArc1_RS11565	COG0517	IMP dehydrogenase activity
AArc1_RS11565	COG1125	glycine betaine transport
AArc1_RS11620	COG0585	pseudouridine synthase activity
AArc1_RS11625	COG4191	Histidine kinase
AArc1_RS11630	COG3920	Histidine kinase
AArc1_RS11630	COG2202	Pas domain
AArc1_RS11640	COG1830	Aldolase
AArc1_RS11645	COG0159	tryptophan synthase activity
AArc1_RS11650	COG0133	tryptophan synthase activity
AArc1_RS11655	COG0134	indole-3-glycerol-phosphate synthase activity
AArc1_RS11665	COG0671	phosphoesterase, PA-phosphatase related
AArc1_RS11685	COG0668	transmembrane transport
AArc1_RS11695	COG0697	spore germination
AArc1_RS11715	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AArc1_RS11725	COG1832	CoA-binding protein
AArc1_RS11735	COG0109	protoheme IX farnesyltransferase activity
AArc1_RS11885	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AArc1_RS11895	COG2271	Major facilitator Superfamily
AArc1_RS11920	COG0517	IMP dehydrogenase activity
AArc1_RS11955	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
AArc1_RS11970	COG2267	carboxylic ester hydrolase activity
AArc1_RS11975	COG1797	cobyrinic acid a,c-diamide synthase activity
AArc1_RS12035	COG0673	inositol 2-dehydrogenase activity
AArc1_RS12060	COG0667	Aldo Keto reductase
AArc1_RS12120	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AArc1_RS12145	COG2201	protein-glutamate methylesterase activity
AArc1_RS12150	COG2201	protein-glutamate methylesterase activity
AArc1_RS12155	COG0643	Histidine kinase
AArc1_RS12155	COG0784	Response regulator, receiver
AArc1_RS12155	COG2198	Histidine kinase
AArc1_RS12170	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
AArc1_RS12175	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AArc1_RS12215	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
AArc1_RS12220	COG1028	Short-chain dehydrogenase reductase Sdr
AArc1_RS12240	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AArc1_RS12275	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AArc1_RS12305	COG0189	ligase activity
AArc1_RS12320	COG1053	succinate dehydrogenase
AArc1_RS12350	COG1960	acyl-CoA dehydrogenase activity
AArc1_RS12355	COG1250	3-hydroxyacyl-CoA dehydrogenase
AArc1_RS12360	COG0745	RESPONSE REGULATOR receiver
AArc1_RS12405	COG4251	negative regulation of phosphorylation
AArc1_RS12445	COG0471	metal ion transport
AArc1_RS12450	COG4770	biotin carboxylase activity
AArc1_RS12460	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AArc1_RS12465	COG0733	neurotransmitter:sodium symporter activity
AArc1_RS12510	COG0446	pyridine nucleotide-disulphide oxidoreductase
AArc1_RS12515	COG0516	GMP reductase activity
AArc1_RS12515	COG0517	IMP dehydrogenase activity
AArc1_RS12530	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
AArc1_RS12585	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AArc1_RS12585	COG0561	phosphatase activity
AArc1_RS12590	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
AArc1_RS12610	COG0475	glutathione-regulated potassium exporter activity
AArc1_RS12610	COG0589	response to stress
AArc1_RS12615	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AArc1_RS12630	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AArc1_RS12730	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AArc1_RS12750	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AArc1_RS12815	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AArc1_RS12820	COG0167	dihydroorotate dehydrogenase activity
AArc1_RS12830	COG2079	MmgE PrpD family protein
AArc1_RS12840	COG2030	dehydratase
AArc1_RS12845	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AArc1_RS12850	COG0589	response to stress
AArc1_RS12855	COG0534	Mate efflux family protein
AArc1_RS12905	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AArc1_RS12915	COG0438	transferase activity, transferring glycosyl groups
AArc1_RS12955	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AArc1_RS12990	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AArc1_RS13000	COG0651	ATP synthesis coupled electron transport
AArc1_RS13005	COG0651	ATP synthesis coupled electron transport
AArc1_RS13010	COG0651	ATP synthesis coupled electron transport
AArc1_RS13015	COG1006	Multisubunit Na H antiporter MnhC subunit
AArc1_RS13030	COG1320	monovalent cation:proton antiporter activity
AArc1_RS13050	COG0668	transmembrane transport
AArc1_RS13060	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
AArc1_RS13065	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AArc1_RS13170	COG1201	RNA secondary structure unwinding
AArc1_RS13190	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AArc1_RS13190	COG0519	Catalyzes the synthesis of GMP from XMP
AArc1_RS13195	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AArc1_RS13215	COG0419	ATPase involved in DNA repair
AArc1_RS13240	COG1404	Belongs to the peptidase S8 family
AArc1_RS13245	COG0396	ATPase activity
AArc1_RS13250	COG0719	Fe-S assembly protein
AArc1_RS13270	COG1012	belongs to the aldehyde dehydrogenase family
AArc1_RS13275	COG0506	proline dehydrogenase activity
AArc1_RS13330	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AArc1_RS13335	COG0010	Belongs to the arginase family
AArc1_RS13340	COG1228	amidohydrolase
AArc1_RS13345	COG2986	histidine ammonia-lyase
AArc1_RS13350	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
AArc1_RS13365	COG2226	methyltransferase
AArc1_RS13385	COG0717	Belongs to the dCTP deaminase family
AArc1_RS13400	COG0572	uridine kinase
AArc1_RS13410	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AArc1_RS13415	COG0602	queuosine metabolic process
AArc1_RS13435	COG1058	Belongs to the CinA family
AArc1_RS13435	COG1546	Belongs to the CinA family
AArc1_RS13455	COG0436	Aminotransferase
AArc1_RS13480	COG3361	conserved protein (COG2071)
AArc1_RS13490	COG1914	H( )-stimulated, divalent metal cation uptake system
AArc1_RS13520	COG1960	acyl-CoA dehydrogenase activity
AArc1_RS13535	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AArc1_RS13540	COG2301	Belongs to the HpcH HpaI aldolase family
AArc1_RS13545	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AArc1_RS13550	COG1607	acyl-coa hydrolase
AArc1_RS13560	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AArc1_RS13575	COG0126	phosphoglycerate kinase activity
AArc1_RS13585	COG0438	transferase activity, transferring glycosyl groups
AArc1_RS13590	COG0589	response to stress
AArc1_RS13605	COG1830	Aldolase
AArc1_RS13615	COG2423	ornithine cyclodeaminase activity
AArc1_RS13625	COG1278	Cold shock
AArc1_RS13650	COG0745	RESPONSE REGULATOR receiver
AArc1_RS13650	COG2205	protein histidine kinase activity
AArc1_RS13650	COG4191	Histidine kinase
AArc1_RS13655	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AArc1_RS13660	COG0109	protoheme IX farnesyltransferase activity
AArc1_RS13670	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AArc1_RS13675	COG0667	Aldo Keto reductase
AArc1_RS13690	COG1131	(ABC) transporter
AArc1_RS13700	COG4251	negative regulation of phosphorylation
AArc1_RS13725	COG0495	leucyl-tRNA aminoacylation
AArc1_RS13740	COG0436	Aminotransferase
AArc1_RS13745	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AArc1_RS13755	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AArc1_RS13760	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AArc1_RS13765	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AArc1_RS13770	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AArc1_RS13775	COG0649	NAD binding
AArc1_RS13780	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AArc1_RS13790	COG0839	Belongs to the complex I subunit 6 family
AArc1_RS13800	COG0713	ATP synthesis coupled electron transport
AArc1_RS13810	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AArc1_RS13815	COG1007	ATP synthesis coupled electron transport
AArc1_RS13825	COG2239	Acts as a magnesium transporter
AArc1_RS13840	COG1028	Short-chain dehydrogenase reductase Sdr
AArc1_RS13875	COG1098	S1 RNA binding domain
AArc1_RS13910	COG0589	response to stress
AArc1_RS13920	COG4608	Belongs to the ABC transporter superfamily
AArc1_RS13935	COG0601	transmembrane transport
AArc1_RS13945	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AArc1_RS13955	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AArc1_RS13960	COG0492	ferredoxin-NADP+ reductase activity
AArc1_RS13975	COG1363	Peptidase, m42
AArc1_RS13990	COG2154	pterin-4-alpha-carbinolamine dehydratase
AArc1_RS13995	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AArc1_RS14005	COG1703	isobutyryl-CoA mutase activity
AArc1_RS14010	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AArc1_RS14010	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AArc1_RS14045	COG2226	methyltransferase
AArc1_RS14055	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AArc1_RS14060	COG2202	Pas domain
AArc1_RS14060	COG3920	Histidine kinase
AArc1_RS14090	COG1122	ATPase activity
AArc1_RS14105	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AArc1_RS14375	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AArc1_RS14380	COG1121	(ABC) transporter
AArc1_RS14405	COG0473	3-isopropylmalate dehydrogenase activity
AArc1_RS14415	COG0066	3-isopropylmalate dehydratase activity
AArc1_RS14420	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AArc1_RS14430	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AArc1_RS14440	COG0028	Belongs to the TPP enzyme family
AArc1_RS14445	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AArc1_RS14490	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AArc1_RS14540	COG1139	Iron-sulfur cluster binding protein
AArc1_RS14645	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AArc1_RS14650	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AArc1_RS14655	COG0247	lactate metabolic process
AArc1_RS14655	COG0277	FAD linked oxidase domain protein
AArc1_RS14660	COG1620	l-lactate permease
AArc1_RS14670	COG1139	Iron-sulfur cluster binding protein
AArc1_RS14675	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AArc1_RS14715	COG1196	nuclear chromosome segregation
AArc1_RS14735	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
AArc1_RS14740	COG0534	Mate efflux family protein
AArc1_RS14745	COG2217	Heavy metal translocating P-type atpase
AArc1_RS14760	COG0534	Mate efflux family protein
AArc1_RS14765	COG0384	phenazine biosynthesis protein PhzF
AArc1_RS14775	COG0076	glutamate decarboxylase activity
AArc1_RS14790	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AArc1_RS14790	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AArc1_RS14800	COG2759	Belongs to the formate--tetrahydrofolate ligase family
AArc1_RS14830	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AArc1_RS14840	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AArc1_RS14845	COG0512	Glutamine amidotransferase of anthranilate synthase
AArc1_RS14870	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AArc1_RS14880	COG0330	HflC and HflK could
AArc1_RS14910	COG0710	3-dehydroquinate dehydratase activity
AArc1_RS14925	COG1465	3-dehydroquinate synthase
AArc1_RS14945	COG0470	DNA polymerase III
AArc1_RS14945	COG1067	ATP-dependent peptidase activity
AArc1_RS14950	COG1051	belongs to the nudix hydrolase family
AArc1_RS14950	COG1056	cytidyltransferase-related domain
AArc1_RS14965	COG0459	protein refolding
AArc1_RS14995	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AArc1_RS15015	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
AArc1_RS15055	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AArc1_RS15075	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AArc1_RS15100	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AArc1_RS15105	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
AArc1_RS15130	COG0601	transmembrane transport
AArc1_RS15135	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AArc1_RS15140	COG0444	Belongs to the ABC transporter superfamily
AArc1_RS15145	COG4608	Belongs to the ABC transporter superfamily
AArc1_RS15180	COG4106	trans-aconitate 2-methyltransferase activity
AArc1_RS15185	COG1024	Enoyl-CoA hydratase
AArc1_RS15230	COG1278	Cold shock
AArc1_RS15260	COG4608	Belongs to the ABC transporter superfamily
AArc1_RS15265	COG0444	Belongs to the ABC transporter superfamily
AArc1_RS15270	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AArc1_RS15275	COG0601	transmembrane transport
AArc1_RS15305	COG1366	Belongs to the anti-sigma-factor antagonist family
AArc1_RS15305	COG2202	Pas domain
AArc1_RS15420	COG2204	response regulator
AArc1_RS15425	COG0784	Response regulator, receiver
AArc1_RS15520	COG0616	signal peptide processing
AArc1_RS15540	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AArc1_RS15550	COG1215	transferase activity, transferring glycosyl groups
AArc1_RS15575	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AArc1_RS15585	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AArc1_RS15585	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AArc1_RS15605	COG0166	Belongs to the GPI family
AArc1_RS15625	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AArc1_RS15635	COG0504	CTP synthase activity
AArc1_RS15640	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AArc1_RS15640	COG0519	Catalyzes the synthesis of GMP from XMP
AArc1_RS15660	COG0521	Mo-molybdopterin cofactor biosynthetic process
AArc1_RS15665	COG0604	alcohol dehydrogenase
AArc1_RS15665	COG1028	Short-chain dehydrogenase reductase Sdr
AArc1_RS15665	COG3321	synthase
AArc1_RS15695	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
AArc1_RS15740	COG0138	bifunctional purine biosynthesis protein purh
AArc1_RS15745	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AArc1_RS15750	COG0318	PFAM AMP-dependent synthetase and ligase
AArc1_RS15785	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AArc1_RS15795	COG0300	oxidoreductase activity
AArc1_RS15800	COG3246	L-lysine catabolic process to acetate
AArc1_RS15805	COG1024	Enoyl-CoA hydratase
AArc1_RS15830	COG0019	diaminopimelate decarboxylase activity
AArc1_RS15835	COG2171	N-acyltransferase activity
AArc1_RS15840	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AArc1_RS15845	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AArc1_RS15855	COG0628	permease
AArc1_RS15860	COG0501	Belongs to the peptidase M48B family
AArc1_RS15885	COG2264	protein methyltransferase activity
AArc1_RS15900	COG2814	Major facilitator Superfamily
AArc1_RS15925	COG0415	Belongs to the DNA photolyase family
AArc1_RS15960	COG0501	Belongs to the peptidase M48B family
AArc1_RS15965	COG0501	Belongs to the peptidase M48B family
AArc1_RS15990	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AArc1_RS15995	COG1234	tRNA 3'-trailer cleavage
AArc1_RS16010	COG1378	Sugar-specific transcriptional regulator TrmB
AArc1_RS16040	COG4555	ABC transporter
AArc1_RS16055	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AArc1_RS16060	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AArc1_RS16075	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AArc1_RS16080	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AArc1_RS16085	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AArc1_RS16100	COG1028	Short-chain dehydrogenase reductase Sdr
AArc1_RS16110	COG0252	asparaginase activity
AArc1_RS16150	COG1028	Short-chain dehydrogenase reductase Sdr
AArc1_RS16160	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AArc1_RS16165	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AArc1_RS16190	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AArc1_RS16195	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AArc1_RS16220	COG0309	Hydrogenase expression formation protein (HypE)
AArc1_RS16230	COG0351	phosphomethylpyrimidine kinase
AArc1_RS16240	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AArc1_RS16300	COG1446	asparaginase
AArc1_RS16305	COG0024	Methionine aminopeptidase
AArc1_RS16325	COG0252	asparaginase activity
AArc1_RS16345	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AArc1_RS16350	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AArc1_RS16355	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AArc1_RS16385	COG3422	double-strand break repair
AArc1_RS16395	COG0628	permease
AArc1_RS16405	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AArc1_RS16460	COG4948	Mandelate Racemase Muconate Lactonizing
AArc1_RS16465	COG0436	Aminotransferase
AArc1_RS16470	COG1028	Short-chain dehydrogenase reductase Sdr
AArc1_RS16480	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AArc1_RS16490	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AArc1_RS16530	COG2873	o-acetylhomoserine
AArc1_RS16535	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AArc1_RS16570	COG0318	PFAM AMP-dependent synthetase and ligase
AArc1_RS16615	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
AArc1_RS16630	COG0616	signal peptide processing
AArc1_RS16635	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AArc1_RS16660	COG2239	Acts as a magnesium transporter
AArc1_RS16665	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AArc1_RS16700	COG1404	Belongs to the peptidase S8 family
AArc1_RS16715	COG3361	conserved protein (COG2071)
AArc1_RS16725	COG0459	protein refolding
AArc1_RS16730	COG1185	polyribonucleotide nucleotidyltransferase activity
AArc1_RS16750	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AArc1_RS16755	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AArc1_RS16770	COG1131	(ABC) transporter
AArc1_RS16785	COG0322	excinuclease ABC activity
AArc1_RS16795	COG0023	Translation Initiation Factor
AArc1_RS16810	COG1247	-acetyltransferase
AArc1_RS16855	COG0556	nucleotide-excision repair
AArc1_RS16920	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AArc1_RS16930	COG1086	Polysaccharide biosynthesis protein
AArc1_RS16955	COG0123	including yeast histone deacetylase and acetoin utilization protein
AArc1_RS17030	COG1335	isochorismatase
AArc1_RS17070	COG0183	Belongs to the thiolase family
AArc1_RS17085	COG2414	aldehyde ferredoxin oxidoreductase
AArc1_RS17095	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AArc1_RS17110	COG1278	Cold shock
AArc1_RS17120	COG0288	reversible hydration of carbon dioxide
AArc1_RS17125	COG2130	NADP-dependent
AArc1_RS17140	COG0842	Transport permease protein
AArc1_RS17145	COG1131	(ABC) transporter
AArc1_RS17190	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AArc1_RS17195	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AArc1_RS17225	COG0085	RNA polymerase activity
AArc1_RS17230	COG0085	RNA polymerase activity
AArc1_RS17235	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AArc1_RS17240	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AArc1_RS17255	COG0049	tRNA binding
AArc1_RS17260	COG0840	transmembrane signaling receptor activity
AArc1_RS17270	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AArc1_RS17280	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
AArc1_RS17300	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AArc1_RS17320	COG0788	formyltetrahydrofolate deformylase activity
AArc1_RS17335	COG0523	cobalamin synthesis protein
AArc1_RS17360	COG0047	phosphoribosylformylglycinamidine synthase activity
AArc1_RS17375	COG2217	Heavy metal translocating P-type atpase
AArc1_RS17400	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AArc1_RS17505	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AArc1_RS17685	COG0022	dehydrogenase e1 component
AArc1_RS17700	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AArc1_RS17720	COG4581	dead DEAH box helicase
AArc1_RS17760	COG1234	tRNA 3'-trailer cleavage
AArc1_RS17765	COG3639	organic phosphonate transmembrane transporter activity
AArc1_RS17770	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
AArc1_RS17830	COG0840	transmembrane signaling receptor activity
AArc1_RS17835	COG1605	Chorismate mutase
AArc1_RS17835	COG0077	Prephenate dehydratase
AArc1_RS17845	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AArc1_RS17855	COG0495	leucyl-tRNA aminoacylation
AArc1_RS17865	COG2181	nitrate reductase activity
AArc1_RS17865	COG0247	lactate metabolic process
AArc1_RS17880	COG1418	mRNA catabolic process
AArc1_RS17885	COG0822	iron-sulfur transferase activity
AArc1_RS17915	COG1960	acyl-CoA dehydrogenase activity
AArc1_RS17930	COG4191	Histidine kinase
AArc1_RS17965	COG1131	(ABC) transporter
AArc1_RS17970	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AArc1_RS17980	COG0402	S-adenosylhomocysteine deaminase activity
AArc1_RS18000	COG2217	Heavy metal translocating P-type atpase
AArc1_RS18005	COG2985	domain, Protein
AArc1_RS18005	COG0569	domain protein
AArc1_RS18045	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AArc1_RS18055	COG0352	thiamine-phosphate diphosphorylase activity
AArc1_RS18060	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
AArc1_RS18125	COG3634	alkyl hydroperoxide reductase activity
AArc1_RS18130	COG0346	lactoylglutathione lyase activity
AArc1_RS18215	COG0137	argininosuccinate synthase activity
AArc1_RS18220	COG0165	Argininosuccinate lyase
AArc1_RS18230	COG0189	ligase activity
AArc1_RS18235	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AArc1_RS18240	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AArc1_RS18245	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AArc1_RS18250	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AArc1_RS18255	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AArc1_RS18260	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AArc1_RS18270	COG0519	Catalyzes the synthesis of GMP from XMP
AArc1_RS18270	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AArc1_RS18275	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AArc1_RS18290	COG3181	Tripartite tricarboxylate transporter family receptor
AArc1_RS18295	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AArc1_RS18320	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AArc1_RS18365	COG2226	methyltransferase
AArc1_RS18370	COG1840	ABC-type Fe3 transport system, periplasmic component
AArc1_RS18375	COG4149	molybdate abc transporter
AArc1_RS18400	COG1160	GTP binding