locus-tag	class	description
DV445_RS00005	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
DV445_RS00035	COG0513	Belongs to the DEAD box helicase family
DV445_RS00055	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DV445_RS00080	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DV445_RS00135	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
DV445_RS00140	COG2207	Transcriptional regulator
DV445_RS00150	COG0488	(ABC) transporter
DV445_RS00155	COG0604	alcohol dehydrogenase
DV445_RS00160	COG1733	regulation of RNA biosynthetic process
DV445_RS00170	COG3384	dioxygenase
DV445_RS00175	COG1335	isochorismatase
DV445_RS00180	COG1522	sequence-specific DNA binding
DV445_RS00185	COG1733	regulation of RNA biosynthetic process
DV445_RS00190	COG0778	Nitroreductase
DV445_RS00220	COG0583	DNA-binding transcription factor activity
DV445_RS00225	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DV445_RS00315	COG1881	PFAM PEBP family protein
DV445_RS00325	COG0625	glutathione transferase activity
DV445_RS00335	COG0456	acetyltransferase
DV445_RS00350	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DV445_RS00400	COG1757	Na H antiporter
DV445_RS00410	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DV445_RS00410	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DV445_RS00425	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
DV445_RS00435	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
DV445_RS00440	COG0431	NADPH-dependent FMN reductase
DV445_RS00450	COG2017	converts alpha-aldose to the beta-anomer
DV445_RS00465	COG0765	amino acid transport
DV445_RS00475	COG1126	abc transporter atp-binding protein
DV445_RS00480	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DV445_RS00485	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DV445_RS00490	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DV445_RS00495	COG1649	PFAM Uncharacterised BCR, COG1649
DV445_RS00495	COG0726	polysaccharide deacetylase
DV445_RS00505	COG1555	photosystem II stabilization
DV445_RS00505	COG1596	polysaccharide export
DV445_RS00570	COG3104	oligopeptide transport
DV445_RS00620	COG1116	anion transmembrane transporter activity
DV445_RS00650	COG0489	protein tyrosine kinase activity
DV445_RS00660	COG1127	ABC transporter
DV445_RS00665	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DV445_RS00670	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
DV445_RS00690	COG5266	PFAM Nickel transport complex, NikM subunit, transmembrane
DV445_RS00695	COG2239	Acts as a magnesium transporter
DV445_RS00700	COG0616	signal peptide processing
DV445_RS00700	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DV445_RS00710	COG1611	Belongs to the LOG family
DV445_RS00730	COG1333	cytochrome c biogenesis protein
DV445_RS00735	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DV445_RS00745	COG0723	plastoquinol--plastocyanin reductase activity
DV445_RS00750	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DV445_RS00755	COG2857	Cytochrome c1
DV445_RS00760	COG0625	glutathione transferase activity
DV445_RS00765	COG2969	positive regulation of protein catabolic process
DV445_RS00770	COG0861	Integral membrane protein TerC family
DV445_RS00785	COG0583	DNA-binding transcription factor activity
DV445_RS00790	COG3842	ATPase activity
DV445_RS00795	COG0688	phosphatidylethanolamine metabolic process
DV445_RS00805	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DV445_RS00815	COG1505	serine-type exopeptidase activity
DV445_RS00855	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
DV445_RS00860	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DV445_RS00875	COG0613	PHP domain protein
DV445_RS00905	COG1192	Involved in chromosome partitioning
DV445_RS00955	COG0791	NLP P60 protein
DV445_RS00985	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DV445_RS01010	COG3676	manually curated
DV445_RS01040	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DV445_RS01050	COG0201	protein transport
DV445_RS01055	COG0200	Binds to the 23S rRNA
DV445_RS01160	COG0644	oxidoreductase
DV445_RS01175	COG0142	geranyltranstransferase activity
DV445_RS01220	COG0612	Peptidase, M16
DV445_RS01235	COG2027	D-alanyl-D-alanine carboxypeptidase
DV445_RS01240	COG1047	Peptidyl-prolyl cis-trans
DV445_RS01245	COG0210	DNA helicase
DV445_RS01275	COG1643	Atp-dependent helicase
DV445_RS01315	COG2119	membrane
DV445_RS01355	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DV445_RS01375	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DV445_RS01390	COG0557	exoribonuclease II activity
DV445_RS01400	COG0471	metal ion transport
DV445_RS01405	COG2962	Rard protein
DV445_RS01435	COG0142	geranyltranstransferase activity
DV445_RS01470	COG1643	Atp-dependent helicase
DV445_RS01475	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
DV445_RS01485	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DV445_RS01525	COG0840	transmembrane signaling receptor activity
DV445_RS01580	COG2226	methyltransferase
DV445_RS01610	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DV445_RS01615	COG0640	Transcriptional regulator
DV445_RS01635	COG1596	polysaccharide export
DV445_RS01635	COG1555	photosystem II stabilization
DV445_RS01715	COG1335	isochorismatase
DV445_RS01720	COG0859	PFAM glycosyl transferase family 9
DV445_RS01740	COG1739	Uncharacterized protein family UPF0029
DV445_RS01800	COG0698	ribose 5-phosphate isomerase
DV445_RS01840	COG4650	regulator
DV445_RS01850	COG1132	(ABC) transporter
DV445_RS01855	COG0758	DNA mediated transformation
DV445_RS01870	COG0742	ribosomal rna small subunit methyltransferase
DV445_RS01875	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
DV445_RS01950	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
DV445_RS01975	COG1289	transmembrane transporter activity
DV445_RS02000	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
DV445_RS02020	COG2375	cellular response to nickel ion
DV445_RS02035	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DV445_RS02070	COG0288	reversible hydration of carbon dioxide
DV445_RS02085	COG0406	alpha-ribazole phosphatase activity
DV445_RS02100	COG0356	it plays a direct role in the translocation of protons across the membrane
DV445_RS02195	COG0628	permease
DV445_RS02225	COG0697	spore germination
DV445_RS02235	COG2832	Protein of unknown function (DUF454)
DV445_RS02240	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
DV445_RS02250	COG0339	signal peptide processing
DV445_RS02295	COG0312	modulator of DNA gyrase
DV445_RS02315	COG1199	ATP-dependent helicase activity
DV445_RS02320	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
DV445_RS02355	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DV445_RS02365	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DV445_RS02370	COG0483	inositol monophosphate 1-phosphatase activity
DV445_RS02425	COG1012	belongs to the aldehyde dehydrogenase family
DV445_RS02455	COG0514	ATP-dependent DNA helicase (RecQ)
DV445_RS02480	COG2252	PERMEase
DV445_RS02490	COG1530	ribonuclease E activity
DV445_RS02510	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DV445_RS02520	COG0824	Thioesterase
DV445_RS02530	COG2954	triphosphatase activity
DV445_RS02535	COG1981	membrane
DV445_RS02545	COG1380	Effector of murein hydrolase LrgA
DV445_RS02550	COG1346	cytolysis
DV445_RS02595	COG2819	hydrolase of the alpha beta superfamily
DV445_RS02605	COG2884	Cell division ATP-binding protein ftsE
DV445_RS02625	COG0583	DNA-binding transcription factor activity
DV445_RS02630	COG0799	negative regulation of ribosome biogenesis
DV445_RS02635	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
DV445_RS02655	COG0517	IMP dehydrogenase activity
DV445_RS02655	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
DV445_RS02695	COG0642	Histidine kinase
DV445_RS02725	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
DV445_RS02730	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
DV445_RS02745	COG2056	Na+-H+ antiporter family
DV445_RS02755	COG0739	heme binding
DV445_RS02810	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DV445_RS02835	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DV445_RS02855	COG4221	oxidoreductase activity
DV445_RS02860	COG4149	molybdate abc transporter
DV445_RS02865	COG0826	peptidase U32
DV445_RS02890	COG3154	lipid carrier protein
DV445_RS02900	COG0024	Methionine aminopeptidase
DV445_RS02935	COG0187	DNA topoisomerase II activity
DV445_RS02950	COG1045	serine acetyltransferase
DV445_RS02975	COG0297	glycogen (starch) synthase activity
DV445_RS02985	COG0733	neurotransmitter:sodium symporter activity
DV445_RS03010	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DV445_RS03125	COG1215	transferase activity, transferring glycosyl groups
DV445_RS03140	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DV445_RS03145	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DV445_RS03150	COG0583	DNA-binding transcription factor activity
DV445_RS03160	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
DV445_RS03170	COG2807	transmembrane transport
DV445_RS03180	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DV445_RS03185	COG0315	cyclic pyranopterin monophosphate synthase activity
DV445_RS03210	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
DV445_RS03255	COG0196	riboflavin kinase activity
DV445_RS03260	COG0765	amino acid transport
DV445_RS03275	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DV445_RS03305	COG0415	Belongs to the DNA photolyase family
DV445_RS03310	COG0429	hydrolase of the alpha beta-hydrolase fold
DV445_RS03345	COG1187	pseudouridine synthase activity
DV445_RS03370	COG1247	-acetyltransferase
DV445_RS03405	COG0463	Glycosyl transferase, family 2
DV445_RS03420	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
DV445_RS03460	COG3278	Belongs to the heme-copper respiratory oxidase family
DV445_RS03475	COG2010	Cytochrome c
DV445_RS03480	COG0500	methyltransferase
DV445_RS03485	COG2321	neutral zinc metallopeptidase
DV445_RS03490	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
DV445_RS03500	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DV445_RS03500	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
DV445_RS03565	COG0729	surface antigen
DV445_RS03570	COG0859	PFAM glycosyl transferase family 9
DV445_RS03580	COG1881	PFAM PEBP family protein
DV445_RS03595	COG1733	regulation of RNA biosynthetic process
DV445_RS03600	COG2249	NAD(P)H dehydrogenase (quinone) activity
DV445_RS03610	COG1629	transport
DV445_RS03610	COG4774	siderophore transport
DV445_RS03630	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DV445_RS03645	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DV445_RS03675	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
DV445_RS03680	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
DV445_RS03695	COG1115	amino acid carrier protein
DV445_RS03700	COG0626	cystathionine gamma-synthase activity
DV445_RS03710	COG1970	mechanosensitive ion channel activity
DV445_RS03720	COG4166	transmembrane transport
DV445_RS03725	COG2885	chlorophyll binding
DV445_RS03735	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DV445_RS03770	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
DV445_RS03780	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
DV445_RS03805	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DV445_RS03805	COG1199	ATP-dependent helicase activity
DV445_RS03840	COG3209	COG3209 Rhs family protein
DV445_RS03885	COG3209	COG3209 Rhs family protein
DV445_RS03975	COG2814	Major facilitator Superfamily
DV445_RS04000	COG4968	Prepilin-type N-terminal cleavage methylation domain
DV445_RS04005	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DV445_RS04035	COG1538	Outer membrane efflux protein
DV445_RS04040	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DV445_RS04070	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
DV445_RS04120	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DV445_RS04125	COG0121	glutamine amidotransferase
DV445_RS04165	COG1278	Cold shock
DV445_RS04170	COG2814	Major facilitator Superfamily
DV445_RS04175	COG4452	Inner membrane protein CreD
DV445_RS04180	COG0745	RESPONSE REGULATOR receiver
DV445_RS04200	COG2205	protein histidine kinase activity
DV445_RS04235	COG0511	ligase activity, forming carbon-carbon bonds
DV445_RS04255	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
DV445_RS04340	COG0268	Binds directly to 16S ribosomal RNA
DV445_RS04380	COG1773	rubredoxin
DV445_RS04385	COG0305	Participates in initiation and elongation during chromosome replication
DV445_RS04400	COG4966	pilus assembly protein PilW
DV445_RS04420	COG1233	COG1233 Phytoene dehydrogenase and related
DV445_RS04445	COG1879	ABC-type sugar transport system periplasmic component
DV445_RS04450	COG1129	ABC transporter
DV445_RS04455	COG4211	Belongs to the binding-protein-dependent transport system permease family
DV445_RS04500	COG1555	photosystem II stabilization
DV445_RS04500	COG1596	polysaccharide export
DV445_RS04510	COG1064	alcohol dehydrogenase
DV445_RS04530	COG3012	SEC-C Motif Domain Protein
DV445_RS04540	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
DV445_RS04615	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DV445_RS04620	COG1115	amino acid carrier protein
DV445_RS04625	COG0529	Catalyzes the synthesis of activated sulfate
DV445_RS04625	COG2895	sulfate adenylyltransferase (ATP) activity
DV445_RS04630	COG4589	Belongs to the CDS family
DV445_RS04650	COG0039	L-malate dehydrogenase activity
DV445_RS04665	COG1053	succinate dehydrogenase
DV445_RS04675	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
DV445_RS04685	COG0567	Dehydrogenase, E1 component
DV445_RS04690	COG0508	dehydrogenase complex catalyzes the overall conversion of
DV445_RS04695	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DV445_RS04700	COG1690	Belongs to the RtcB family
DV445_RS04735	COG2841	Protein conserved in bacteria
DV445_RS04740	COG1091	dTDP-4-dehydrorhamnose reductase activity
DV445_RS04760	COG3245	cytochrome
DV445_RS04795	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DV445_RS04800	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DV445_RS04835	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DV445_RS04910	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DV445_RS04965	COG5007	Belongs to the BolA IbaG family
DV445_RS04970	COG2350	Protein conserved in bacteria
DV445_RS05040	COG0561	phosphatase activity
DV445_RS05070	COG0708	Exodeoxyribonuclease III
DV445_RS05095	COG2204	response regulator
DV445_RS05100	COG5000	phosphorelay sensor kinase activity
DV445_RS05130	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DV445_RS05155	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
DV445_RS05160	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
DV445_RS05165	COG1034	ATP synthesis coupled electron transport
DV445_RS05205	COG1605	Chorismate mutase
DV445_RS05205	COG0287	Prephenate dehydrogenase
DV445_RS05230	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DV445_RS05235	COG2354	Protein conserved in bacteria
DV445_RS05285	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DV445_RS05295	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DV445_RS05310	COG1047	Peptidyl-prolyl cis-trans
DV445_RS05320	COG0277	FAD linked oxidase domain protein
DV445_RS05355	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
DV445_RS05385	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
DV445_RS05385	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
DV445_RS05385	COG0506	proline dehydrogenase activity
DV445_RS05395	COG1063	alcohol dehydrogenase
DV445_RS05400	COG2233	PERMEase
DV445_RS05425	COG1058	Belongs to the CinA family
DV445_RS05425	COG1546	Belongs to the CinA family
DV445_RS05435	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
DV445_RS05440	COG3945	hemerythrin HHE cation binding domain
DV445_RS05465	COG2959	enzyme of heme biosynthesis
DV445_RS05475	COG2304	oxidoreductase activity
DV445_RS05495	COG1464	Belongs to the NlpA lipoprotein family
DV445_RS05500	COG2011	ABC-type metal ion transport system permease component
DV445_RS05505	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DV445_RS05510	COG0803	Belongs to the bacterial solute-binding protein 9 family
DV445_RS05545	COG1187	pseudouridine synthase activity
DV445_RS05575	COG3279	Response regulator of the LytR AlgR family
DV445_RS05580	COG1519	Transferase
DV445_RS05625	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DV445_RS05630	COG4605	iron ion homeostasis
DV445_RS05635	COG4604	ABC transporter, ATP-binding protein
DV445_RS05640	COG0714	Associated with various cellular activities
DV445_RS05680	COG1555	photosystem II stabilization
DV445_RS05680	COG1596	polysaccharide export
DV445_RS05710	COG3541	Predicted nucleotidyltransferase
DV445_RS05740	COG1215	transferase activity, transferring glycosyl groups
DV445_RS05745	COG2824	Alkylphosphonate utilization operon protein PhnA
DV445_RS05770	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DV445_RS05775	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DV445_RS05790	COG1994	Peptidase M50
DV445_RS05800	COG0009	L-threonylcarbamoyladenylate synthase
DV445_RS05825	COG0469	pyruvate kinase activity
DV445_RS05840	COG4185	zeta toxin
DV445_RS05910	COG0270	DNA (cytosine-5-)-methyltransferase activity
DV445_RS05980	COG1396	sequence-specific DNA binding
DV445_RS05995	COG3645	SOS response
DV445_RS06015	COG1802	Transcriptional regulator
DV445_RS06015	COG4626	Terminase
DV445_RS06020	COG1484	DNA-dependent DNA replication
DV445_RS06050	COG1783	phage Terminase large subunit
DV445_RS06060	COG2369	cell adhesion
DV445_RS06260	COG1702	phosphate starvation-inducible protein PhoH
DV445_RS06265	COG0791	NLP P60 protein
DV445_RS06295	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DV445_RS06325	COG4174	ABC transporter (Permease)
DV445_RS06350	COG0778	Nitroreductase
DV445_RS06385	COG1560	Kdo2-lipid A biosynthetic process
DV445_RS06395	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DV445_RS06445	COG0084	hydrolase, TatD family'
DV445_RS06450	COG0730	response to heat
DV445_RS06455	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
DV445_RS06485	COG2226	methyltransferase
DV445_RS06505	COG1129	ABC transporter
DV445_RS06505	COG0842	Transport permease protein
DV445_RS06510	COG2315	Protein conserved in bacteria
DV445_RS06545	COG1794	racemase activity, acting on amino acids and derivatives
DV445_RS06550	COG0842	Transport permease protein
DV445_RS06590	COG0492	ferredoxin-NADP+ reductase activity
DV445_RS06620	COG3275	phosphorelay sensor kinase activity
DV445_RS06630	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DV445_RS06645	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
DV445_RS06660	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
DV445_RS06665	COG4120	Belongs to the binding-protein-dependent transport system permease family
DV445_RS06675	COG2960	long-chain fatty acid transporting porin activity
DV445_RS06680	COG1074	ATP-dependent DNA helicase activity
DV445_RS06700	COG2733	membrane
DV445_RS06715	COG0204	Acyl-transferase
DV445_RS06750	COG4178	(ABC) transporter
DV445_RS06755	COG4774	siderophore transport
DV445_RS06775	COG0569	domain protein
DV445_RS06850	COG0512	Glutamine amidotransferase of anthranilate synthase
DV445_RS06850	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DV445_RS06860	COG3568	Endonuclease Exonuclease Phosphatase
DV445_RS06870	COG0671	phosphoesterase, PA-phosphatase related
DV445_RS06870	COG2453	phosphatase
DV445_RS06900	COG2975	iron-sulfur cluster assembly
DV445_RS06935	COG0316	Belongs to the HesB IscA family
DV445_RS06945	COG0822	iron-sulfur transferase activity
DV445_RS06975	COG1304	FMN binding
DV445_RS06980	COG0123	including yeast histone deacetylase and acetoin utilization protein
DV445_RS06985	COG0318	PFAM AMP-dependent synthetase and ligase
DV445_RS07000	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
DV445_RS07005	COG1280	lysine exporter protein (LysE YggA)
DV445_RS07015	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
DV445_RS07030	COG0471	metal ion transport
DV445_RS07055	COG0488	(ABC) transporter
DV445_RS07065	COG0772	Belongs to the SEDS family
DV445_RS07070	COG0768	penicillin binding
DV445_RS07085	COG1077	Cell shape determining protein MreB Mrl
DV445_RS07100	COG4884	unkown
DV445_RS07100	COG3831	ATPase activity
DV445_RS07105	COG1278	Cold shock
DV445_RS07165	COG0521	Mo-molybdopterin cofactor biosynthetic process
DV445_RS07170	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
DV445_RS07230	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DV445_RS07240	COG0393	Putative heavy-metal-binding
DV445_RS07245	COG0393	Putative heavy-metal-binding
DV445_RS07275	COG0494	nUDIX hydrolase
DV445_RS07280	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
DV445_RS07280	COG3264	Mechanosensitive ion channel
DV445_RS07285	COG3012	SEC-C Motif Domain Protein
DV445_RS07285	COG3318	Belongs to the UPF0149 family
DV445_RS07310	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DV445_RS07320	COG0508	dehydrogenase complex catalyzes the overall conversion of
DV445_RS07330	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
DV445_RS07340	COG1177	transmembrane transport
DV445_RS07345	COG1176	ABC-type spermidine putrescine transport system, permease component I
DV445_RS07350	COG3842	ATPase activity
DV445_RS07360	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DV445_RS07370	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
DV445_RS07395	COG2866	Carboxypeptidase
DV445_RS07400	COG0697	spore germination
DV445_RS07410	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DV445_RS07430	COG0859	PFAM glycosyl transferase family 9
DV445_RS07455	COG1561	YicC-like family, N-terminal region
DV445_RS07470	COG0517	IMP dehydrogenase activity
DV445_RS07470	COG1125	glycine betaine transport
DV445_RS07490	COG1648	precorrin-2 dehydrogenase activity
DV445_RS07490	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DV445_RS07500	COG0248	Ppx GppA phosphatase
DV445_RS07515	COG1610	YqeY-like protein
DV445_RS07535	COG0756	dUTP diphosphatase activity
DV445_RS07560	COG0523	cobalamin synthesis protein
DV445_RS07600	COG0488	(ABC) transporter
DV445_RS07610	COG0012	GTP binding
DV445_RS07615	COG0338	D12 class N6 adenine-specific DNA methyltransferase
DV445_RS07640	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
DV445_RS07700	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DV445_RS07715	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
DV445_RS07735	COG2217	Heavy metal translocating P-type atpase
DV445_RS07740	COG2608	mercury ion transmembrane transporter activity
DV445_RS07745	COG0789	Transcriptional regulator
DV445_RS07790	COG1397	ADP-ribosylglycohydrolase
DV445_RS07880	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DV445_RS07890	COG1902	pentaerythritol trinitrate reductase activity
DV445_RS07910	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
DV445_RS07915	COG1765	OsmC-like protein
DV445_RS07920	COG0857	belongs to the CobB CobQ family
DV445_RS07920	COG0280	phosphate acetyltransferase
DV445_RS07930	COG1253	flavin adenine dinucleotide binding
DV445_RS07940	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DV445_RS07945	COG1183	phosphatidylcholine synthase activity
DV445_RS07970	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DV445_RS07980	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
DV445_RS08025	COG1234	tRNA 3'-trailer cleavage
DV445_RS08035	COG0679	Auxin Efflux Carrier
DV445_RS08040	COG1619	proteins homologs of microcin C7 resistance protein MccF
DV445_RS08050	COG0281	malic enzyme
DV445_RS08050	COG0280	phosphate acetyltransferase
DV445_RS08060	COG0628	permease
DV445_RS08065	COG3161	chorismate lyase activity
DV445_RS08085	COG0307	riboflavin synthase, alpha
DV445_RS08090	COG4221	oxidoreductase activity
DV445_RS08095	COG3909	cytochrome
DV445_RS08100	COG2814	Major facilitator Superfamily
DV445_RS08105	COG0247	lactate metabolic process
DV445_RS08115	COG2848	UPF0210 protein
DV445_RS08120	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
DV445_RS08135	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DV445_RS08145	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
DV445_RS08160	COG0385	Bile acid
DV445_RS08170	COG0252	asparaginase activity
DV445_RS08175	COG0564	pseudouridine synthase activity
DV445_RS08225	COG0730	response to heat
DV445_RS08230	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
DV445_RS08235	COG0488	(ABC) transporter
DV445_RS08255	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DV445_RS08265	COG0720	synthase
DV445_RS08270	COG0826	peptidase U32
DV445_RS08280	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
DV445_RS08285	COG0589	response to stress
DV445_RS08290	COG0330	HflC and HflK could
DV445_RS08300	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
DV445_RS08305	COG1085	galactose-1-phosphate uridylyltransferase
DV445_RS08335	COG1862	Preprotein translocase
DV445_RS08340	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DV445_RS08345	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DV445_RS08360	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
DV445_RS08380	COG3038	cytochrome b561
DV445_RS08420	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DV445_RS08470	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
DV445_RS08485	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DV445_RS08495	COG1595	DNA-templated transcription, initiation
DV445_RS08515	COG2259	Doxx family
DV445_RS08545	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DV445_RS08570	COG0733	neurotransmitter:sodium symporter activity
DV445_RS08635	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DV445_RS08640	COG1854	S-ribosylhomocysteine lyase activity
DV445_RS08645	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
DV445_RS08650	COG1518	maintenance of DNA repeat elements
DV445_RS08655	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DV445_RS08710	COG0477	Major facilitator Superfamily
DV445_RS08740	COG0436	Aminotransferase
DV445_RS08745	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DV445_RS08760	COG2274	protein secretion by the type I secretion system
DV445_RS08830	COG1324	tolerance protein
DV445_RS08840	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DV445_RS08845	COG0586	Pfam SNARE associated Golgi protein
DV445_RS08850	COG2608	mercury ion transmembrane transporter activity
DV445_RS08855	COG1028	Short-chain dehydrogenase reductase Sdr
DV445_RS08860	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DV445_RS08870	COG1686	Belongs to the peptidase S11 family
DV445_RS08875	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DV445_RS08880	COG0484	heat shock protein binding
DV445_RS08890	COG2995	paraquat-inducible protein a
DV445_RS08920	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DV445_RS08945	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DV445_RS08955	COG1408	metallophosphoesterase
DV445_RS08995	COG1966	Carbon starvation protein
DV445_RS09005	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
DV445_RS09030	COG0497	DNA recombination
DV445_RS09070	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DV445_RS09100	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
DV445_RS09105	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DV445_RS09125	COG0277	FAD linked oxidase domain protein
DV445_RS09135	COG0681	Belongs to the peptidase S26 family
DV445_RS09150	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
DV445_RS09160	COG1448	Aminotransferase
DV445_RS09165	COG1049	propionate catabolic process, 2-methylcitrate cycle
DV445_RS09170	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
DV445_RS09185	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
DV445_RS09185	COG3008	intermembrane lipid transfer
DV445_RS09200	COG2369	cell adhesion
DV445_RS09210	COG4373	Mu-like prophage FluMu protein gp28
DV445_RS09495	COG0513	Belongs to the DEAD box helicase family
DV445_RS09505	COG0612	Peptidase, M16
DV445_RS09540	COG0741	lytic transglycosylase activity
DV445_RS09540	COG1388	LysM domain
DV445_RS09555	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DV445_RS09570	COG0512	Glutamine amidotransferase of anthranilate synthase
DV445_RS09605	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DV445_RS09815	COG0175	sulfate reduction
DV445_RS09875	COG0708	Exodeoxyribonuclease III
DV445_RS09890	COG0786	glutamate:sodium symporter activity
DV445_RS09895	COG0179	Fumarylacetoacetate (FAA) hydrolase
DV445_RS09910	COG1217	gtp-binding protein TYPA
DV445_RS09915	COG0598	Magnesium transport protein CorA
DV445_RS09920	COG1607	acyl-coa hydrolase
DV445_RS09925	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DV445_RS09930	COG1393	Belongs to the ArsC family
DV445_RS09960	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DV445_RS09960	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DV445_RS09995	COG3676	manually curated
DV445_RS10025	COG0105	UTP biosynthetic process
DV445_RS10030	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
DV445_RS10085	COG3800	Transcriptional regulator
DV445_RS10085	COG1396	sequence-specific DNA binding
DV445_RS10135	COG1027	Aspartate ammonia-lyase
DV445_RS10155	COG1028	Short-chain dehydrogenase reductase Sdr
DV445_RS10205	COG0582	viral genome integration into host DNA
DV445_RS10230	COG0745	RESPONSE REGULATOR receiver
DV445_RS10235	COG0277	FAD linked oxidase domain protein
DV445_RS10240	COG2837	iron assimilation
DV445_RS10245	COG2951	lytic endotransglycosylase activity
DV445_RS10275	COG1012	belongs to the aldehyde dehydrogenase family
DV445_RS10295	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
DV445_RS10305	COG4172	Belongs to the ABC transporter superfamily
DV445_RS10310	COG4239	(ABC) transporter, permease
DV445_RS10335	COG2353	YceI-like domain
DV445_RS10395	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
DV445_RS10410	COG0285	dihydrofolate synthase activity
DV445_RS10415	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DV445_RS10435	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DV445_RS10475	COG1012	belongs to the aldehyde dehydrogenase family
DV445_RS10485	COG4208	sulfate ABC transporter
DV445_RS10545	COG0586	Pfam SNARE associated Golgi protein
DV445_RS10560	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DV445_RS10570	COG1534	Rna-binding protein
DV445_RS10575	COG2095	MarC family integral membrane protein
DV445_RS10600	COG0433	COG0433 Predicted ATPase
DV445_RS10610	COG0560	Phosphoserine phosphatase
DV445_RS10645	COG0277	FAD linked oxidase domain protein
DV445_RS10660	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DV445_RS10680	COG0084	hydrolase, TatD family'
DV445_RS10695	COG0408	coproporphyrinogen oxidase activity
DV445_RS10735	COG3263	regulation of cellular component size
DV445_RS10760	COG0633	Ferredoxin
DV445_RS10765	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DV445_RS10770	COG1757	Na H antiporter
DV445_RS10775	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DV445_RS10870	COG0625	glutathione transferase activity
DV445_RS10875	COG0443	Heat shock 70 kDa protein
DV445_RS10895	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DV445_RS10895	COG2813	Specifically methylates the guanine in position
DV445_RS10910	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DV445_RS10915	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DV445_RS10920	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
DV445_RS10925	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DV445_RS10930	COG4558	Periplasmic binding protein
DV445_RS10935	COG4771	TonB-dependent receptor
DV445_RS10945	COG2314	TM2 domain
DV445_RS10950	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
DV445_RS10980	COG2267	carboxylic ester hydrolase activity
DV445_RS10985	COG0351	phosphomethylpyrimidine kinase
DV445_RS11020	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
DV445_RS11020	COG0644	oxidoreductase
DV445_RS11025	COG1968	undecaprenyl-diphosphatase activity
DV445_RS11055	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DV445_RS11065	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
DV445_RS11080	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DV445_RS11110	COG2852	Protein conserved in bacteria
DV445_RS11115	COG2233	PERMEase
DV445_RS11125	COG0538	isocitrate dehydrogenase activity
DV445_RS11160	COG3245	cytochrome
DV445_RS11170	COG0028	Belongs to the TPP enzyme family
DV445_RS11175	COG0440	acetolactate synthase activity
DV445_RS11180	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
DV445_RS11185	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DV445_RS11195	COG0287	Prephenate dehydrogenase
DV445_RS11225	COG0793	Belongs to the peptidase S41A family
DV445_RS11255	COG0778	Nitroreductase
DV445_RS11260	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DV445_RS11265	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DV445_RS11270	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DV445_RS11285	COG3313	Fe-S protein
DV445_RS11325	COG2991	Protein conserved in bacteria
DV445_RS11330	COG1477	protein flavinylation
DV445_RS11345	COG3738	Protein conserved in bacteria
DV445_RS11355	COG2833	Protein of unknown function (DUF455)
DV445_RS11405	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DV445_RS11415	COG1002	Type II restriction enzyme, methylase subunits
DV445_RS11420	COG3392	D12 class N6 adenine-specific DNA methyltransferase
DV445_RS11485	COG3646	Phage regulatory protein
DV445_RS11540	COG4397	Mu-like prophage major head subunit gpT
DV445_RS11560	COG4383	Mu-like prophage protein gp29
DV445_RS11630	COG0776	regulation of translation
DV445_RS11655	COG4396	Host-nuclease inhibitor protein Gam
DV445_RS11715	COG1028	Short-chain dehydrogenase reductase Sdr
DV445_RS11720	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DV445_RS11755	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
DV445_RS11755	COG0678	peroxiredoxin activity
DV445_RS11770	COG2885	chlorophyll binding
DV445_RS11770	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
DV445_RS11775	COG1196	nuclear chromosome segregation
DV445_RS11790	COG0617	tRNA 3'-terminal CCA addition
DV445_RS11815	COG0802	atpase or kinase
DV445_RS11830	COG2186	Transcriptional regulator
DV445_RS11835	COG0247	lactate metabolic process
DV445_RS11845	COG1139	Iron-sulfur cluster binding protein
DV445_RS11850	COG1620	l-lactate permease
DV445_RS11865	COG2878	Part of a membrane complex involved in electron transport
DV445_RS11885	COG0741	lytic transglycosylase activity
DV445_RS11905	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DV445_RS11945	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
DV445_RS11955	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
DV445_RS11965	COG0800	Aldolase
DV445_RS11980	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
DV445_RS11985	COG1137	ATPase activity
DV445_RS12000	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DV445_RS12030	COG0300	oxidoreductase activity
DV445_RS12040	COG4178	(ABC) transporter
DV445_RS12060	COG3256	nitric oxide reductase
DV445_RS12075	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DV445_RS12170	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DV445_RS12230	COG1073	alpha beta
DV445_RS12295	COG1999	signal sequence binding
DV445_RS12315	COG0436	Aminotransferase
DV445_RS12340	COG0195	Participates in both transcription termination and antitermination
DV445_RS12340	COG2251	uridine kinase activity
DV445_RS12350	COG0805	protein transport
DV445_RS12380	COG3045	CreA protein
DV445_RS12400	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DV445_RS12440	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
DV445_RS12480	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DV445_RS12485	COG1376	ErfK ybiS ycfS ynhG family protein
DV445_RS12500	COG0312	modulator of DNA gyrase
DV445_RS12505	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DV445_RS12510	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DV445_RS12515	COG1562	ergosterol biosynthetic process
DV445_RS12520	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DV445_RS12550	COG0582	viral genome integration into host DNA
DV445_RS12645	COG0629	single-stranded DNA binding
DV445_RS12665	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
DV445_RS12670	COG2948	multi-organism process
DV445_RS12685	COG3704	protein secretion by the type IV secretion system
DV445_RS12695	COG3451	type IV secretory pathway VirB4
DV445_RS12730	COG1253	flavin adenine dinucleotide binding
DV445_RS12735	COG0702	epimerase
DV445_RS12745	COG3585	molybdate ion transport
DV445_RS12760	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DV445_RS12765	COG0318	PFAM AMP-dependent synthetase and ligase
DV445_RS12780	COG4942	peptidase
DV445_RS12800	COG0519	Catalyzes the synthesis of GMP from XMP
DV445_RS12805	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
DV445_RS12810	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DV445_RS12820	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DV445_RS12835	COG0308	aminopeptidase N
DV445_RS12840	COG1530	ribonuclease E activity
DV445_RS12860	COG1793	dna ligase
DV445_RS12865	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid