locus-tag	class	description
NGK_RS00090	COG1956	GAF domain-containing protein
NGK_RS00095	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
NGK_RS00100	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NGK_RS00125	COG1505	serine-type exopeptidase activity
NGK_RS00155	COG1214	PFAM Peptidase M22, glycoprotease
NGK_RS00220	COG0439	Biotin carboxylase
NGK_RS00225	COG0511	ligase activity, forming carbon-carbon bonds
NGK_RS00255	COG2852	Protein conserved in bacteria
NGK_RS00295	COG0489	protein tyrosine kinase activity
NGK_RS00305	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NGK_RS00340	COG0012	GTP binding
NGK_RS00370	COG0196	riboflavin kinase activity
NGK_RS00445	COG0613	PHP domain protein
NGK_RS00450	COG3977	Valine--pyruvate aminotransferase
NGK_RS00460	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
NGK_RS00465	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
NGK_RS00475	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NGK_RS00475	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NGK_RS00485	COG0121	glutamine amidotransferase
NGK_RS00550	COG1333	cytochrome c biogenesis protein
NGK_RS00555	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
NGK_RS00580	COG0431	NADPH-dependent FMN reductase
NGK_RS00595	COG2851	Citrate transporter
NGK_RS00610	COG1530	ribonuclease E activity
NGK_RS00625	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
NGK_RS00705	COG0720	synthase
NGK_RS00710	COG3759	membrane
NGK_RS00730	COG1757	Na H antiporter
NGK_RS00740	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NGK_RS00745	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
NGK_RS00765	COG1757	Na H antiporter
NGK_RS00785	COG3676	manually curated
NGK_RS00805	COG0513	Belongs to the DEAD box helicase family
NGK_RS00815	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NGK_RS00830	COG1560	Kdo2-lipid A biosynthetic process
NGK_RS00845	COG0308	aminopeptidase N
NGK_RS00850	COG3676	manually curated
NGK_RS00900	COG0803	Belongs to the bacterial solute-binding protein 9 family
NGK_RS00905	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NGK_RS00940	COG2205	protein histidine kinase activity
NGK_RS00945	COG0745	RESPONSE REGULATOR receiver
NGK_RS00965	COG0805	protein transport
NGK_RS00990	COG1063	alcohol dehydrogenase
NGK_RS01005	COG3676	manually curated
NGK_RS01040	COG3676	manually curated
NGK_RS01080	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NGK_RS01090	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
NGK_RS01120	COG0616	signal peptide processing
NGK_RS01135	COG2084	Dehydrogenase
NGK_RS01165	COG1999	signal sequence binding
NGK_RS01175	COG0028	Belongs to the TPP enzyme family
NGK_RS01200	COG1049	propionate catabolic process, 2-methylcitrate cycle
NGK_RS01235	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
NGK_RS01245	COG1765	OsmC-like protein
NGK_RS01250	COG1802	Transcriptional regulator
NGK_RS01255	COG2431	L-lysine efflux transmembrane transporter activity
NGK_RS01290	COG0318	PFAM AMP-dependent synthetase and ligase
NGK_RS01300	COG3676	manually curated
NGK_RS01305	COG1943	Transposase
NGK_RS01335	COG0512	Glutamine amidotransferase of anthranilate synthase
NGK_RS01350	COG0123	including yeast histone deacetylase and acetoin utilization protein
NGK_RS01355	COG1862	Preprotein translocase
NGK_RS01360	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NGK_RS01365	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NGK_RS01375	COG3842	ATPase activity
NGK_RS01380	COG1176	ABC-type spermidine putrescine transport system, permease component I
NGK_RS01385	COG1177	transmembrane transport
NGK_RS01390	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NGK_RS01395	COG0004	ammonium transporteR
NGK_RS01415	COG3676	manually curated
NGK_RS01430	COG2833	Protein of unknown function (DUF455)
NGK_RS01455	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
NGK_RS01495	COG1178	ABC-type Fe3 transport system permease component
NGK_RS01515	COG1210	Utp--glucose-1-phosphate uridylyltransferase
NGK_RS01535	COG0494	nUDIX hydrolase
NGK_RS01600	COG0635	Involved in the biosynthesis of porphyrin-containing compound
NGK_RS01615	COG3023	N-Acetylmuramoyl-L-alanine amidase
NGK_RS01620	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
NGK_RS01630	COG0280	phosphate acetyltransferase
NGK_RS01630	COG0281	malic enzyme
NGK_RS01680	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
NGK_RS01760	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
NGK_RS01775	COG0285	dihydrofolate synthase activity
NGK_RS01790	COG1126	abc transporter atp-binding protein
NGK_RS01850	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
NGK_RS01855	COG1466	dna polymerase III delta subunit
NGK_RS01870	COG1561	YicC-like family, N-terminal region
NGK_RS01890	COG2354	Protein conserved in bacteria
NGK_RS01990	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
NGK_RS01990	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
NGK_RS02000	COG3161	chorismate lyase activity
NGK_RS02030	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
NGK_RS02035	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
NGK_RS02055	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NGK_RS02055	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
NGK_RS02075	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
NGK_RS02100	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
NGK_RS02170	COG0681	Belongs to the peptidase S26 family
NGK_RS02180	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
NGK_RS02200	COG0084	hydrolase, TatD family'
NGK_RS02210	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
NGK_RS02305	COG1074	ATP-dependent DNA helicase activity
NGK_RS02310	COG2837	iron assimilation
NGK_RS02320	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NGK_RS02325	COG0765	amino acid transport
NGK_RS02330	COG1126	abc transporter atp-binding protein
NGK_RS02340	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
NGK_RS02345	COG0471	metal ion transport
NGK_RS02370	COG2867	negative regulation of translational initiation
NGK_RS02375	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NGK_RS02395	COG0626	cystathionine gamma-synthase activity
NGK_RS02405	COG0778	Nitroreductase
NGK_RS02410	COG1187	pseudouridine synthase activity
NGK_RS02425	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NGK_RS02430	COG1309	transcriptional regulator
NGK_RS02475	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
NGK_RS02475	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
NGK_RS02490	COG3645	SOS response
NGK_RS02510	COG0542	response to heat
NGK_RS02520	COG1278	Cold shock
NGK_RS02525	COG0312	modulator of DNA gyrase
NGK_RS02555	COG1702	phosphate starvation-inducible protein PhoH
NGK_RS02560	COG0438	transferase activity, transferring glycosyl groups
NGK_RS02640	COG0564	pseudouridine synthase activity
NGK_RS02705	COG1686	Belongs to the peptidase S11 family
NGK_RS02710	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
NGK_RS02725	COG4208	sulfate ABC transporter
NGK_RS02740	COG1755	Isoprenylcysteine carboxyl methyltransferase
NGK_RS02745	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
NGK_RS02750	COG0305	Participates in initiation and elongation during chromosome replication
NGK_RS02795	COG0436	Aminotransferase
NGK_RS02895	COG1476	TRANSCRIPTIONal
NGK_RS02930	COG0305	Participates in initiation and elongation during chromosome replication
NGK_RS03045	COG3617	BRO family, N-terminal domain
NGK_RS03080	COG4221	oxidoreductase activity
NGK_RS03085	COG1607	acyl-coa hydrolase
NGK_RS03195	COG1966	Carbon starvation protein
NGK_RS03210	COG1012	belongs to the aldehyde dehydrogenase family
NGK_RS03225	COG1253	flavin adenine dinucleotide binding
NGK_RS03240	COG1607	acyl-coa hydrolase
NGK_RS03285	COG1942	4-Oxalocrotonate Tautomerase
NGK_RS03290	COG0436	Aminotransferase
NGK_RS03355	COG2814	Major facilitator Superfamily
NGK_RS03365	COG0697	spore germination
NGK_RS03390	COG0348	domain, Protein
NGK_RS03400	COG2070	2-Nitropropane dioxygenase
NGK_RS03475	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
NGK_RS03570	COG3945	hemerythrin HHE cation binding domain
NGK_RS03605	COG0859	PFAM glycosyl transferase family 9
NGK_RS03620	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
NGK_RS03625	COG0277	FAD linked oxidase domain protein
NGK_RS03645	COG1562	ergosterol biosynthetic process
NGK_RS03685	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
NGK_RS03715	COG0765	amino acid transport
NGK_RS03745	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
NGK_RS03750	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
NGK_RS03755	COG0589	response to stress
NGK_RS03835	COG0590	tRNA wobble adenosine to inosine editing
NGK_RS03875	COG2813	Specifically methylates the guanine in position
NGK_RS03875	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
NGK_RS03915	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
NGK_RS03915	COG0678	peroxiredoxin activity
NGK_RS03945	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
NGK_RS03960	COG0567	Dehydrogenase, E1 component
NGK_RS03965	COG0508	dehydrogenase complex catalyzes the overall conversion of
NGK_RS03970	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NGK_RS03995	COG2963	transposase activity
NGK_RS04015	COG1139	Iron-sulfur cluster binding protein
NGK_RS04025	COG0247	lactate metabolic process
NGK_RS04030	COG0477	Major facilitator Superfamily
NGK_RS04035	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NGK_RS04040	COG0791	NLP P60 protein
NGK_RS04095	COG0277	FAD linked oxidase domain protein
NGK_RS04120	COG1773	rubredoxin
NGK_RS04130	COG2963	transposase activity
NGK_RS04155	COG4150	thiosulfate binding
NGK_RS04165	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
NGK_RS04190	COG0488	(ABC) transporter
NGK_RS04195	COG0586	Pfam SNARE associated Golgi protein
NGK_RS04205	COG1476	TRANSCRIPTIONal
NGK_RS04225	COG2841	Protein conserved in bacteria
NGK_RS04245	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
NGK_RS04305	COG3012	SEC-C Motif Domain Protein
NGK_RS04305	COG3318	Belongs to the UPF0149 family
NGK_RS04315	COG2866	Carboxypeptidase
NGK_RS04340	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
NGK_RS04345	COG4178	(ABC) transporter
NGK_RS04375	COG0300	oxidoreductase activity
NGK_RS04380	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
NGK_RS04385	COG1562	ergosterol biosynthetic process
NGK_RS04425	COG2975	iron-sulfur cluster assembly
NGK_RS04430	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
NGK_RS04445	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NGK_RS04465	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
NGK_RS04525	COG1217	gtp-binding protein TYPA
NGK_RS04545	COG0557	exoribonuclease II activity
NGK_RS04600	COG0628	permease
NGK_RS04625	COG1192	Involved in chromosome partitioning
NGK_RS04665	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
NGK_RS04705	COG4453	Protein conserved in bacteria
NGK_RS04940	COG0488	(ABC) transporter
NGK_RS04965	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
NGK_RS05015	COG1393	Belongs to the ArsC family
NGK_RS05020	COG0488	(ABC) transporter
NGK_RS05045	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
NGK_RS05060	COG0307	riboflavin synthase, alpha
NGK_RS05070	COG3850	Histidine kinase
NGK_RS05075	COG2197	response regulator
NGK_RS05085	COG3676	manually curated
NGK_RS05095	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
NGK_RS05120	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
NGK_RS05145	COG0210	DNA helicase
NGK_RS05170	COG0582	viral genome integration into host DNA
NGK_RS05190	COG3676	manually curated
NGK_RS05235	COG3093	addiction module antidote protein HigA
NGK_RS05300	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
NGK_RS05310	COG0800	Aldolase
NGK_RS05325	COG1194	a g-specific adenine glycosylase
NGK_RS05340	COG2831	hemolysin activation secretion protein
NGK_RS05405	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
NGK_RS05410	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
NGK_RS05470	COG2217	Heavy metal translocating P-type atpase
NGK_RS05475	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
NGK_RS05485	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
NGK_RS05530	COG3676	manually curated
NGK_RS05555	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
NGK_RS05555	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NGK_RS05570	COG1012	belongs to the aldehyde dehydrogenase family
NGK_RS05575	COG2095	MarC family integral membrane protein
NGK_RS05590	COG2990	Protein conserved in bacteria
NGK_RS05600	COG0543	2 iron, 2 sulfur cluster binding
NGK_RS05600	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NGK_RS05625	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
NGK_RS05650	COG0513	Belongs to the DEAD box helicase family
NGK_RS05700	COG2189	Belongs to the N(4) N(6)-methyltransferase family
NGK_RS05705	COG2189	Belongs to the N(4) N(6)-methyltransferase family
NGK_RS05710	COG3421	Type III restriction
NGK_RS05715	COG1304	FMN binding
NGK_RS05745	COG0822	iron-sulfur transferase activity
NGK_RS05750	COG0316	Belongs to the HesB IscA family
NGK_RS05755	COG3036	rescue of stalled ribosome
NGK_RS05770	COG3676	manually curated
NGK_RS05785	COG2951	lytic endotransglycosylase activity
NGK_RS05800	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
NGK_RS05840	COG0633	Ferredoxin
NGK_RS05845	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NGK_RS05850	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NGK_RS05875	COG1388	LysM domain
NGK_RS05875	COG0741	lytic transglycosylase activity
NGK_RS05885	COG0733	neurotransmitter:sodium symporter activity
NGK_RS05905	COG0789	Transcriptional regulator
NGK_RS05915	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
NGK_RS05920	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
NGK_RS05980	COG1183	phosphatidylcholine synthase activity
NGK_RS05985	COG0730	response to heat
NGK_RS06015	COG0492	ferredoxin-NADP+ reductase activity
NGK_RS06020	COG2217	Heavy metal translocating P-type atpase
NGK_RS06065	COG0793	Belongs to the peptidase S41A family
NGK_RS06075	COG3045	CreA protein
NGK_RS06090	COG0179	Fumarylacetoacetate (FAA) hydrolase
NGK_RS06100	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
NGK_RS06105	COG0508	dehydrogenase complex catalyzes the overall conversion of
NGK_RS06115	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NGK_RS06145	COG3676	manually curated
NGK_RS06155	COG1027	Aspartate ammonia-lyase
NGK_RS06175	COG0697	spore germination
NGK_RS06190	COG0251	oxidation-reduction process
NGK_RS06215	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
NGK_RS06220	COG0523	cobalamin synthesis protein
NGK_RS06230	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NGK_RS06260	COG2814	Major facilitator Superfamily
NGK_RS06265	COG2814	Major facilitator Superfamily
NGK_RS06290	COG0318	PFAM AMP-dependent synthetase and ligase
NGK_RS06295	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
NGK_RS06300	COG3676	manually curated
NGK_RS06450	COG5410	chromosome segregation
NGK_RS06505	COG1484	DNA-dependent DNA replication
NGK_RS06645	COG1442	glycosyl transferase family 8
NGK_RS06645	COG1216	Glycosyl transferase, family 2
NGK_RS06710	COG1619	proteins homologs of microcin C7 resistance protein MccF
NGK_RS06725	COG1262	PFAM Formylglycine-generating sulfatase enzyme
NGK_RS06755	COG0778	Nitroreductase
NGK_RS06760	COG2194	sulfuric ester hydrolase activity
NGK_RS06790	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
NGK_RS06800	COG1272	protein, Hemolysin III
NGK_RS06805	COG1115	amino acid carrier protein
NGK_RS06870	COG3676	manually curated
NGK_RS06915	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
NGK_RS06920	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NGK_RS06940	COG0561	phosphatase activity
NGK_RS06950	COG0826	peptidase U32
NGK_RS06965	COG3676	manually curated
NGK_RS06975	COG2995	paraquat-inducible protein a
NGK_RS06980	COG3008	intermembrane lipid transfer
NGK_RS06980	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
NGK_RS06990	COG0519	Catalyzes the synthesis of GMP from XMP
NGK_RS07020	COG3245	cytochrome
NGK_RS07030	COG1448	Aminotransferase
NGK_RS07065	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NGK_RS07080	COG0252	asparaginase activity
NGK_RS07085	COG0586	Pfam SNARE associated Golgi protein
NGK_RS07100	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
NGK_RS07135	COG1028	Short-chain dehydrogenase reductase Sdr
NGK_RS07140	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NGK_RS07165	COG0733	neurotransmitter:sodium symporter activity
NGK_RS07185	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
NGK_RS07200	COG1620	l-lactate permease
NGK_RS07240	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
NGK_RS07245	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
NGK_RS07255	COG2010	Cytochrome c
NGK_RS07270	COG3278	Belongs to the heme-copper respiratory oxidase family
NGK_RS07280	COG3453	Protein conserved in bacteria
NGK_RS07280	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NGK_RS07300	COG1994	Peptidase M50
NGK_RS07305	COG2999	glutathione oxidoreductase activity
NGK_RS07310	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NGK_RS07410	COG3676	manually curated
NGK_RS07420	COG0644	oxidoreductase
NGK_RS07420	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
NGK_RS07430	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
NGK_RS07460	COG3901	Regulator of nitric oxide reductase transcription
NGK_RS07460	COG0348	domain, Protein
NGK_RS07495	COG1522	sequence-specific DNA binding
NGK_RS07505	COG2832	Protein of unknown function (DUF454)
NGK_RS07520	COG3676	manually curated
NGK_RS07555	COG1477	protein flavinylation
NGK_RS07560	COG2991	Protein conserved in bacteria
NGK_RS07570	COG1045	serine acetyltransferase
NGK_RS07625	COG1116	anion transmembrane transporter activity
NGK_RS07640	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
NGK_RS07645	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NGK_RS07655	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NGK_RS07665	COG1196	nuclear chromosome segregation
NGK_RS07690	COG1620	l-lactate permease
NGK_RS07705	COG1448	Aminotransferase
NGK_RS07775	COG0560	Phosphoserine phosphatase
NGK_RS07785	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
NGK_RS07795	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
NGK_RS07800	COG2249	NAD(P)H dehydrogenase (quinone) activity
NGK_RS07805	COG0583	DNA-binding transcription factor activity
NGK_RS07855	COG0500	methyltransferase
NGK_RS07860	COG2830	Protein of unknown function (DUF452)
NGK_RS07870	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NGK_RS07875	COG1376	ErfK ybiS ycfS ynhG family protein
NGK_RS07880	COG0471	metal ion transport
NGK_RS07960	COG0802	atpase or kinase
NGK_RS08010	COG2814	Major facilitator Superfamily
NGK_RS08020	COG0697	spore germination
NGK_RS08035	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NGK_RS08040	COG0287	Prephenate dehydrogenase
NGK_RS08055	COG1959	2 iron, 2 sulfur cluster binding
NGK_RS08060	COG0009	L-threonylcarbamoyladenylate synthase
NGK_RS08085	COG0372	Belongs to the citrate synthase family
NGK_RS08100	COG2252	PERMEase
NGK_RS08160	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
NGK_RS08165	COG2194	sulfuric ester hydrolase activity
NGK_RS08230	COG2960	long-chain fatty acid transporting porin activity
NGK_RS08280	COG0708	Exodeoxyribonuclease III
NGK_RS08355	COG0488	(ABC) transporter
NGK_RS08360	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
NGK_RS08365	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
NGK_RS08385	COG0583	DNA-binding transcription factor activity
NGK_RS08390	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NGK_RS08395	COG0635	Involved in the biosynthesis of porphyrin-containing compound
NGK_RS08515	COG2814	Major facilitator Superfamily
NGK_RS08545	COG1137	ATPase activity
NGK_RS08550	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
NGK_RS08560	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
NGK_RS08700	COG4626	Terminase
NGK_RS08700	COG1802	Transcriptional regulator
NGK_RS08710	COG1484	DNA-dependent DNA replication
NGK_RS08855	COG0564	pseudouridine synthase activity
NGK_RS08860	COG3676	manually curated
NGK_RS08865	COG0347	Belongs to the P(II) protein family
NGK_RS08880	COG0640	Transcriptional regulator
NGK_RS08890	COG2239	Acts as a magnesium transporter
NGK_RS08900	COG0791	NLP P60 protein
NGK_RS08910	COG1380	Effector of murein hydrolase LrgA
NGK_RS08915	COG1346	cytolysis
NGK_RS08925	COG0038	chloride channel
NGK_RS08930	COG1643	Atp-dependent helicase
NGK_RS08945	COG1643	Atp-dependent helicase
NGK_RS09045	COG0569	domain protein
NGK_RS09060	COG3676	manually curated
NGK_RS09080	COG0351	phosphomethylpyrimidine kinase
NGK_RS09160	COG3617	BRO family, N-terminal domain
NGK_RS09190	COG2350	Protein conserved in bacteria
NGK_RS09210	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
NGK_RS09225	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NGK_RS09280	COG0142	geranyltranstransferase activity
NGK_RS09330	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
NGK_RS09335	COG0739	heme binding
NGK_RS09370	COG1981	membrane
NGK_RS09375	COG2954	triphosphatase activity
NGK_RS09385	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
NGK_RS09445	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
NGK_RS09470	COG2259	Doxx family
NGK_RS09475	COG0583	DNA-binding transcription factor activity
NGK_RS09480	COG0415	Belongs to the DNA photolyase family
NGK_RS09485	COG1199	ATP-dependent helicase activity
NGK_RS09495	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
NGK_RS09510	COG0557	exoribonuclease II activity
NGK_RS09515	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NGK_RS09530	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NGK_RS09550	COG0514	ATP-dependent DNA helicase (RecQ)
NGK_RS09560	COG2226	methyltransferase
NGK_RS09570	COG1040	competence protein
NGK_RS09575	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
NGK_RS09600	COG1132	(ABC) transporter
NGK_RS09615	COG0142	geranyltranstransferase activity
NGK_RS09685	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
NGK_RS09690	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
NGK_RS09710	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NGK_RS09725	COG3676	manually curated
NGK_RS09775	COG1546	Belongs to the CinA family
NGK_RS09805	COG2824	Alkylphosphonate utilization operon protein PhnA
NGK_RS09810	COG2837	iron assimilation
NGK_RS09855	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NGK_RS09900	COG3842	ATPase activity
NGK_RS09905	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NGK_RS09920	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
NGK_RS09925	COG1793	dna ligase
NGK_RS09930	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NGK_RS09940	COG2857	Cytochrome c1
NGK_RS09945	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
NGK_RS09950	COG0723	plastoquinol--plastocyanin reductase activity
NGK_RS09960	COG0583	DNA-binding transcription factor activity
NGK_RS10000	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
NGK_RS10015	COG2056	Na+-H+ antiporter family
NGK_RS10025	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NGK_RS10030	COG1126	abc transporter atp-binding protein
NGK_RS10040	COG0765	amino acid transport
NGK_RS10045	COG0312	modulator of DNA gyrase
NGK_RS10095	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
NGK_RS10145	COG0708	Exodeoxyribonuclease III
NGK_RS10170	COG3038	cytochrome b561
NGK_RS10200	COG0024	Methionine aminopeptidase
NGK_RS10315	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
NGK_RS10315	COG0616	signal peptide processing
NGK_RS10320	COG1546	Belongs to the CinA family
NGK_RS10320	COG1058	Belongs to the CinA family
NGK_RS10355	COG0729	surface antigen
NGK_RS10365	COG3104	oligopeptide transport
NGK_RS10390	COG2259	Doxx family
NGK_RS10405	COG3219	Protein conserved in bacteria
NGK_RS10410	COG1595	DNA-templated transcription, initiation
NGK_RS10450	COG1739	Uncharacterized protein family UPF0029
NGK_RS10465	COG0859	PFAM glycosyl transferase family 9
NGK_RS10470	COG1335	isochorismatase
NGK_RS10515	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NGK_RS10520	COG2884	Cell division ATP-binding protein ftsE
NGK_RS10550	COG0861	Integral membrane protein TerC family
NGK_RS10560	COG1519	Transferase
NGK_RS10565	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
NGK_RS10595	COG1289	transmembrane transporter activity
NGK_RS10620	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
NGK_RS10680	COG1297	OPT oligopeptide transporter protein
NGK_RS10730	COG0786	glutamate:sodium symporter activity
NGK_RS10775	COG0469	pyruvate kinase activity
NGK_RS10885	COG1652	LysM domain
NGK_RS10915	COG5000	phosphorelay sensor kinase activity
NGK_RS10920	COG2204	response regulator
NGK_RS10925	COG0758	DNA mediated transformation
NGK_RS10950	COG0742	ribosomal rna small subunit methyltransferase
NGK_RS10955	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
NGK_RS10985	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
NGK_RS11185	COG0201	protein transport
NGK_RS11195	COG0257	Belongs to the bacterial ribosomal protein bL36 family
NGK_RS11270	COG1115	amino acid carrier protein
NGK_RS11360	COG1192	Involved in chromosome partitioning
NGK_RS11375	COG1115	amino acid carrier protein
NGK_RS11385	COG1530	ribonuclease E activity
NGK_RS11435	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
NGK_RS11480	COG1760	l-serine dehydratase
NGK_RS11495	COG0339	signal peptide processing
NGK_RS11500	COG1858	cytochrome C peroxidase
NGK_RS11510	COG0753	catalase activity
NGK_RS11540	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NGK_RS11575	COG0210	DNA helicase
NGK_RS11600	COG1368	sulfuric ester hydrolase activity
NGK_RS11610	COG0814	amino acid
NGK_RS11625	COG3265	gluconokinase activity
NGK_RS11630	COG2610	gluconate transmembrane transporter activity
NGK_RS11640	COG0288	reversible hydration of carbon dioxide
NGK_RS11650	COG0799	negative regulation of ribosome biogenesis
NGK_RS11680	COG3676	manually curated
NGK_RS11685	COG4604	ABC transporter, ATP-binding protein
NGK_RS11695	COG4605	iron ion homeostasis
NGK_RS11700	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NGK_RS11725	COG0733	neurotransmitter:sodium symporter activity
NGK_RS11755	COG4316	Uncharacterized protein conserved in bacteria (DUF2251)
NGK_RS11810	COG0512	Glutamine amidotransferase of anthranilate synthase
NGK_RS11810	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
NGK_RS11830	COG1127	ABC transporter
NGK_RS11835	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
NGK_RS11840	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
NGK_RS11845	COG2854	intermembrane phospholipid transfer
NGK_RS11865	COG0824	Thioesterase
NGK_RS11900	COG0625	glutathione transferase activity
NGK_RS11905	COG2969	positive regulation of protein catabolic process
NGK_RS11915	COG1610	YqeY-like protein
NGK_RS11935	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
NGK_RS11940	COG2011	ABC-type metal ion transport system permease component
NGK_RS11945	COG1464	Belongs to the NlpA lipoprotein family
NGK_RS11975	COG0356	it plays a direct role in the translocation of protons across the membrane
NGK_RS12025	COG1216	Glycosyl transferase, family 2
NGK_RS12035	COG1442	glycosyl transferase family 8
NGK_RS12040	COG1216	Glycosyl transferase, family 2
NGK_RS12050	COG1385	rRNA (uridine-N3-)-methyltransferase activity
NGK_RS12055	COG0483	inositol monophosphate 1-phosphatase activity
NGK_RS12065	COG1028	Short-chain dehydrogenase reductase Sdr
NGK_RS12080	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
NGK_RS12125	COG1399	metal-binding, possibly nucleic acid-binding protein
NGK_RS12185	COG0592	DNA-directed DNA polymerase activity
NGK_RS12270	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3