locus-tag	class	description
BZG34_RS00055	COG0338	D12 class N6 adenine-specific DNA methyltransferase
BZG34_RS00125	COG1956	GAF domain-containing protein
BZG34_RS00130	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BZG34_RS00135	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BZG34_RS00170	COG1505	serine-type exopeptidase activity
BZG34_RS00200	COG1214	PFAM Peptidase M22, glycoprotease
BZG34_RS00260	COG0439	Biotin carboxylase
BZG34_RS00265	COG0511	ligase activity, forming carbon-carbon bonds
BZG34_RS00300	COG2852	Protein conserved in bacteria
BZG34_RS00345	COG0489	protein tyrosine kinase activity
BZG34_RS00355	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BZG34_RS00390	COG0012	GTP binding
BZG34_RS00430	COG0196	riboflavin kinase activity
BZG34_RS00545	COG0613	PHP domain protein
BZG34_RS00550	COG3977	Valine--pyruvate aminotransferase
BZG34_RS00560	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BZG34_RS00565	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BZG34_RS00575	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BZG34_RS00575	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BZG34_RS00585	COG0121	glutamine amidotransferase
BZG34_RS00670	COG1333	cytochrome c biogenesis protein
BZG34_RS00675	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BZG34_RS00705	COG0431	NADPH-dependent FMN reductase
BZG34_RS00715	COG2851	Citrate transporter
BZG34_RS00730	COG1530	ribonuclease E activity
BZG34_RS00745	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BZG34_RS00830	COG0720	synthase
BZG34_RS00840	COG3759	membrane
BZG34_RS00860	COG1757	Na H antiporter
BZG34_RS00870	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BZG34_RS00875	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BZG34_RS00895	COG1757	Na H antiporter
BZG34_RS00945	COG0513	Belongs to the DEAD box helicase family
BZG34_RS00955	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BZG34_RS00970	COG1560	Kdo2-lipid A biosynthetic process
BZG34_RS00985	COG0308	aminopeptidase N
BZG34_RS00990	COG3676	manually curated
BZG34_RS01040	COG0803	Belongs to the bacterial solute-binding protein 9 family
BZG34_RS01045	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BZG34_RS01085	COG0745	RESPONSE REGULATOR receiver
BZG34_RS01105	COG0805	protein transport
BZG34_RS01130	COG1063	alcohol dehydrogenase
BZG34_RS01160	COG1643	Atp-dependent helicase
BZG34_RS01175	COG1643	Atp-dependent helicase
BZG34_RS01190	COG1346	cytolysis
BZG34_RS01195	COG1380	Effector of murein hydrolase LrgA
BZG34_RS01210	COG0791	NLP P60 protein
BZG34_RS01225	COG2239	Acts as a magnesium transporter
BZG34_RS01235	COG0640	Transcriptional regulator
BZG34_RS01250	COG0347	Belongs to the P(II) protein family
BZG34_RS01255	COG3676	manually curated
BZG34_RS01265	COG0561	phosphatase activity
BZG34_RS01270	COG0564	pseudouridine synthase activity
BZG34_RS01540	COG0305	Participates in initiation and elongation during chromosome replication
BZG34_RS01650	COG3617	BRO family, N-terminal domain
BZG34_RS01695	COG4221	oxidoreductase activity
BZG34_RS01700	COG1607	acyl-coa hydrolase
BZG34_RS01730	COG3676	manually curated
BZG34_RS01820	COG3676	manually curated
BZG34_RS01830	COG1966	Carbon starvation protein
BZG34_RS01850	COG1012	belongs to the aldehyde dehydrogenase family
BZG34_RS01865	COG1253	flavin adenine dinucleotide binding
BZG34_RS01880	COG1607	acyl-coa hydrolase
BZG34_RS01920	COG1942	4-Oxalocrotonate Tautomerase
BZG34_RS01925	COG0436	Aminotransferase
BZG34_RS02005	COG2814	Major facilitator Superfamily
BZG34_RS02020	COG0697	spore germination
BZG34_RS02045	COG0348	domain, Protein
BZG34_RS02055	COG2070	2-Nitropropane dioxygenase
BZG34_RS02130	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BZG34_RS02185	COG1518	maintenance of DNA repeat elements
BZG34_RS02235	COG3945	hemerythrin HHE cation binding domain
BZG34_RS02270	COG0859	PFAM glycosyl transferase family 9
BZG34_RS02300	COG0277	FAD linked oxidase domain protein
BZG34_RS02320	COG1562	ergosterol biosynthetic process
BZG34_RS02360	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BZG34_RS02390	COG0765	amino acid transport
BZG34_RS02415	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
BZG34_RS02425	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BZG34_RS02435	COG0589	response to stress
BZG34_RS02520	COG0590	tRNA wobble adenosine to inosine editing
BZG34_RS02555	COG2813	Specifically methylates the guanine in position
BZG34_RS02555	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BZG34_RS02595	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
BZG34_RS02595	COG0678	peroxiredoxin activity
BZG34_RS02625	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BZG34_RS02645	COG0567	Dehydrogenase, E1 component
BZG34_RS02650	COG0508	dehydrogenase complex catalyzes the overall conversion of
BZG34_RS02655	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BZG34_RS02685	COG2963	transposase activity
BZG34_RS02690	COG2801	Transposase and inactivated derivatives
BZG34_RS02695	COG2801	Transposase and inactivated derivatives
BZG34_RS02710	COG1139	Iron-sulfur cluster binding protein
BZG34_RS02720	COG0247	lactate metabolic process
BZG34_RS02725	COG0477	Major facilitator Superfamily
BZG34_RS02730	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BZG34_RS02735	COG0791	NLP P60 protein
BZG34_RS02795	COG0277	FAD linked oxidase domain protein
BZG34_RS02815	COG1773	rubredoxin
BZG34_RS02830	COG2963	transposase activity
BZG34_RS02835	COG2801	Transposase and inactivated derivatives
BZG34_RS02840	COG2801	Transposase and inactivated derivatives
BZG34_RS02865	COG4150	thiosulfate binding
BZG34_RS02875	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BZG34_RS02900	COG0488	(ABC) transporter
BZG34_RS02905	COG0586	Pfam SNARE associated Golgi protein
BZG34_RS02920	COG1476	TRANSCRIPTIONal
BZG34_RS02945	COG2841	Protein conserved in bacteria
BZG34_RS02965	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
BZG34_RS03040	COG3318	Belongs to the UPF0149 family
BZG34_RS03040	COG3012	SEC-C Motif Domain Protein
BZG34_RS03050	COG2866	Carboxypeptidase
BZG34_RS03075	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BZG34_RS03105	COG0300	oxidoreductase activity
BZG34_RS03110	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
BZG34_RS03115	COG1562	ergosterol biosynthetic process
BZG34_RS03160	COG2975	iron-sulfur cluster assembly
BZG34_RS03165	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
BZG34_RS03180	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BZG34_RS03200	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BZG34_RS03260	COG1217	gtp-binding protein TYPA
BZG34_RS03280	COG0557	exoribonuclease II activity
BZG34_RS03335	COG0628	permease
BZG34_RS03365	COG1192	Involved in chromosome partitioning
BZG34_RS03410	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BZG34_RS03455	COG4453	Protein conserved in bacteria
BZG34_RS03700	COG0488	(ABC) transporter
BZG34_RS03725	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BZG34_RS03785	COG1393	Belongs to the ArsC family
BZG34_RS03790	COG0488	(ABC) transporter
BZG34_RS03820	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BZG34_RS03840	COG3850	Histidine kinase
BZG34_RS03845	COG2197	response regulator
BZG34_RS03875	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BZG34_RS03900	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BZG34_RS03930	COG0210	DNA helicase
BZG34_RS03975	COG3676	manually curated
BZG34_RS04025	COG3093	addiction module antidote protein HigA
BZG34_RS04090	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BZG34_RS04105	COG0800	Aldolase
BZG34_RS04120	COG1194	a g-specific adenine glycosylase
BZG34_RS04210	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BZG34_RS04215	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BZG34_RS04275	COG2217	Heavy metal translocating P-type atpase
BZG34_RS04280	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BZG34_RS04290	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BZG34_RS04335	COG3676	manually curated
BZG34_RS04365	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BZG34_RS04365	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BZG34_RS04380	COG1012	belongs to the aldehyde dehydrogenase family
BZG34_RS04385	COG2095	MarC family integral membrane protein
BZG34_RS04400	COG2990	Protein conserved in bacteria
BZG34_RS04410	COG0543	2 iron, 2 sulfur cluster binding
BZG34_RS04410	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BZG34_RS04440	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BZG34_RS04470	COG0513	Belongs to the DEAD box helicase family
BZG34_RS04525	COG2189	Belongs to the N(4) N(6)-methyltransferase family
BZG34_RS04530	COG2189	Belongs to the N(4) N(6)-methyltransferase family
BZG34_RS04535	COG3421	Type III restriction
BZG34_RS04540	COG1304	FMN binding
BZG34_RS04570	COG0822	iron-sulfur transferase activity
BZG34_RS04575	COG0316	Belongs to the HesB IscA family
BZG34_RS04580	COG3036	rescue of stalled ribosome
BZG34_RS04595	COG3676	manually curated
BZG34_RS04610	COG2951	lytic endotransglycosylase activity
BZG34_RS04625	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BZG34_RS04660	COG0633	Ferredoxin
BZG34_RS04665	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BZG34_RS04670	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BZG34_RS04705	COG1388	LysM domain
BZG34_RS04705	COG0741	lytic transglycosylase activity
BZG34_RS04715	COG0733	neurotransmitter:sodium symporter activity
BZG34_RS04735	COG0789	Transcriptional regulator
BZG34_RS04745	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
BZG34_RS04750	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
BZG34_RS04810	COG1183	phosphatidylcholine synthase activity
BZG34_RS04815	COG0730	response to heat
BZG34_RS04845	COG0492	ferredoxin-NADP+ reductase activity
BZG34_RS04850	COG2217	Heavy metal translocating P-type atpase
BZG34_RS04890	COG0793	Belongs to the peptidase S41A family
BZG34_RS04905	COG3045	CreA protein
BZG34_RS04920	COG0179	Fumarylacetoacetate (FAA) hydrolase
BZG34_RS04930	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
BZG34_RS04935	COG0508	dehydrogenase complex catalyzes the overall conversion of
BZG34_RS04945	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BZG34_RS04965	COG3676	manually curated
BZG34_RS04980	COG1027	Aspartate ammonia-lyase
BZG34_RS05000	COG0697	spore germination
BZG34_RS05015	COG0251	oxidation-reduction process
BZG34_RS05040	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BZG34_RS05045	COG0523	cobalamin synthesis protein
BZG34_RS05055	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BZG34_RS05090	COG2814	Major facilitator Superfamily
BZG34_RS05110	COG0318	PFAM AMP-dependent synthetase and ligase
BZG34_RS05115	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BZG34_RS05280	COG5410	chromosome segregation
BZG34_RS05330	COG0305	Participates in initiation and elongation during chromosome replication
BZG34_RS05465	COG0436	Aminotransferase
BZG34_RS05510	COG0305	Participates in initiation and elongation during chromosome replication
BZG34_RS05520	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BZG34_RS05530	COG1755	Isoprenylcysteine carboxyl methyltransferase
BZG34_RS05545	COG4208	sulfate ABC transporter
BZG34_RS05555	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BZG34_RS05560	COG1686	Belongs to the peptidase S11 family
BZG34_RS05630	COG0564	pseudouridine synthase activity
BZG34_RS05715	COG0438	transferase activity, transferring glycosyl groups
BZG34_RS05720	COG1702	phosphate starvation-inducible protein PhoH
BZG34_RS05755	COG0312	modulator of DNA gyrase
BZG34_RS05760	COG1278	Cold shock
BZG34_RS05770	COG0542	response to heat
BZG34_RS05790	COG3645	SOS response
BZG34_RS05805	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
BZG34_RS05805	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
BZG34_RS05870	COG1309	transcriptional regulator
BZG34_RS05875	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BZG34_RS05890	COG1187	pseudouridine synthase activity
BZG34_RS05895	COG0778	Nitroreductase
BZG34_RS05905	COG0626	cystathionine gamma-synthase activity
BZG34_RS05925	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BZG34_RS05930	COG2867	negative regulation of translational initiation
BZG34_RS05960	COG0471	metal ion transport
BZG34_RS05965	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BZG34_RS05975	COG1126	abc transporter atp-binding protein
BZG34_RS05980	COG0765	amino acid transport
BZG34_RS05985	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BZG34_RS05995	COG2837	iron assimilation
BZG34_RS06000	COG1074	ATP-dependent DNA helicase activity
BZG34_RS06110	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
BZG34_RS06120	COG0084	hydrolase, TatD family'
BZG34_RS06140	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BZG34_RS06150	COG0681	Belongs to the peptidase S26 family
BZG34_RS06235	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BZG34_RS06265	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BZG34_RS06285	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
BZG34_RS06285	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BZG34_RS06310	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BZG34_RS06315	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
BZG34_RS06350	COG3161	chorismate lyase activity
BZG34_RS06360	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BZG34_RS06360	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BZG34_RS06490	COG1561	YicC-like family, N-terminal region
BZG34_RS06505	COG1466	dna polymerase III delta subunit
BZG34_RS06510	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
BZG34_RS06580	COG1126	abc transporter atp-binding protein
BZG34_RS06595	COG0285	dihydrofolate synthase activity
BZG34_RS06610	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
BZG34_RS06705	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
BZG34_RS06760	COG0281	malic enzyme
BZG34_RS06760	COG0280	phosphate acetyltransferase
BZG34_RS06770	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BZG34_RS06775	COG3023	N-Acetylmuramoyl-L-alanine amidase
BZG34_RS06790	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BZG34_RS06865	COG0494	nUDIX hydrolase
BZG34_RS06885	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BZG34_RS06910	COG1178	ABC-type Fe3 transport system permease component
BZG34_RS06950	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
BZG34_RS06980	COG2833	Protein of unknown function (DUF455)
BZG34_RS06995	COG3676	manually curated
BZG34_RS07020	COG0004	ammonium transporteR
BZG34_RS07025	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BZG34_RS07035	COG1177	transmembrane transport
BZG34_RS07040	COG1176	ABC-type spermidine putrescine transport system, permease component I
BZG34_RS07045	COG3842	ATPase activity
BZG34_RS07055	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BZG34_RS07060	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BZG34_RS07065	COG1862	Preprotein translocase
BZG34_RS07070	COG0123	including yeast histone deacetylase and acetoin utilization protein
BZG34_RS07085	COG0512	Glutamine amidotransferase of anthranilate synthase
BZG34_RS07135	COG0318	PFAM AMP-dependent synthetase and ligase
BZG34_RS07170	COG2431	L-lysine efflux transmembrane transporter activity
BZG34_RS07175	COG1802	Transcriptional regulator
BZG34_RS07185	COG1765	OsmC-like protein
BZG34_RS07195	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BZG34_RS07225	COG1049	propionate catabolic process, 2-methylcitrate cycle
BZG34_RS07250	COG0028	Belongs to the TPP enzyme family
BZG34_RS07260	COG1999	signal sequence binding
BZG34_RS07290	COG2084	Dehydrogenase
BZG34_RS07305	COG0616	signal peptide processing
BZG34_RS07335	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BZG34_RS07345	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BZG34_RS07480	COG1619	proteins homologs of microcin C7 resistance protein MccF
BZG34_RS07495	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BZG34_RS07520	COG0778	Nitroreductase
BZG34_RS07525	COG2194	sulfuric ester hydrolase activity
BZG34_RS07555	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BZG34_RS07565	COG1272	protein, Hemolysin III
BZG34_RS07570	COG1115	amino acid carrier protein
BZG34_RS07645	COG3676	manually curated
BZG34_RS07715	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BZG34_RS07720	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BZG34_RS07740	COG0561	phosphatase activity
BZG34_RS07750	COG0826	peptidase U32
BZG34_RS07775	COG3676	manually curated
BZG34_RS07785	COG2995	paraquat-inducible protein a
BZG34_RS07790	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BZG34_RS07790	COG3008	intermembrane lipid transfer
BZG34_RS07800	COG0519	Catalyzes the synthesis of GMP from XMP
BZG34_RS07845	COG3245	cytochrome
BZG34_RS07855	COG1448	Aminotransferase
BZG34_RS07890	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BZG34_RS07905	COG0252	asparaginase activity
BZG34_RS07910	COG0586	Pfam SNARE associated Golgi protein
BZG34_RS07925	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
BZG34_RS07955	COG1028	Short-chain dehydrogenase reductase Sdr
BZG34_RS07990	COG0733	neurotransmitter:sodium symporter activity
BZG34_RS08005	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BZG34_RS08020	COG1620	l-lactate permease
BZG34_RS08070	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
BZG34_RS08075	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
BZG34_RS08090	COG2010	Cytochrome c
BZG34_RS08105	COG3278	Belongs to the heme-copper respiratory oxidase family
BZG34_RS08115	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BZG34_RS08115	COG3453	Protein conserved in bacteria
BZG34_RS08135	COG1994	Peptidase M50
BZG34_RS08140	COG2999	glutathione oxidoreductase activity
BZG34_RS08150	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BZG34_RS08265	COG3676	manually curated
BZG34_RS08275	COG0644	oxidoreductase
BZG34_RS08275	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
BZG34_RS08285	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
BZG34_RS08305	COG3901	Regulator of nitric oxide reductase transcription
BZG34_RS08305	COG0348	domain, Protein
BZG34_RS08345	COG1522	sequence-specific DNA binding
BZG34_RS08355	COG2832	Protein of unknown function (DUF454)
BZG34_RS08370	COG3676	manually curated
BZG34_RS08405	COG1477	protein flavinylation
BZG34_RS08410	COG2991	Protein conserved in bacteria
BZG34_RS08420	COG1045	serine acetyltransferase
BZG34_RS08470	COG1116	anion transmembrane transporter activity
BZG34_RS08485	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BZG34_RS08490	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BZG34_RS08500	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BZG34_RS08510	COG1196	nuclear chromosome segregation
BZG34_RS08535	COG1620	l-lactate permease
BZG34_RS08550	COG1448	Aminotransferase
BZG34_RS08630	COG0560	Phosphoserine phosphatase
BZG34_RS08640	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
BZG34_RS08650	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
BZG34_RS08655	COG2249	NAD(P)H dehydrogenase (quinone) activity
BZG34_RS08665	COG0583	DNA-binding transcription factor activity
BZG34_RS08700	COG0500	methyltransferase
BZG34_RS08705	COG2830	Protein of unknown function (DUF452)
BZG34_RS08715	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BZG34_RS08720	COG1376	ErfK ybiS ycfS ynhG family protein
BZG34_RS08835	COG0802	atpase or kinase
BZG34_RS08915	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BZG34_RS08920	COG0287	Prephenate dehydrogenase
BZG34_RS08940	COG1959	2 iron, 2 sulfur cluster binding
BZG34_RS08945	COG0009	L-threonylcarbamoyladenylate synthase
BZG34_RS08975	COG0372	Belongs to the citrate synthase family
BZG34_RS08990	COG2252	PERMEase
BZG34_RS09065	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BZG34_RS09070	COG2194	sulfuric ester hydrolase activity
BZG34_RS09135	COG2960	long-chain fatty acid transporting porin activity
BZG34_RS09195	COG0708	Exodeoxyribonuclease III
BZG34_RS09245	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BZG34_RS09270	COG0488	(ABC) transporter
BZG34_RS09275	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
BZG34_RS09280	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
BZG34_RS09305	COG0583	DNA-binding transcription factor activity
BZG34_RS09310	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BZG34_RS09315	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BZG34_RS09440	COG2814	Major facilitator Superfamily
BZG34_RS09470	COG1137	ATPase activity
BZG34_RS09475	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
BZG34_RS09485	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
BZG34_RS09625	COG1802	Transcriptional regulator
BZG34_RS09625	COG4626	Terminase
BZG34_RS09630	COG1484	DNA-dependent DNA replication
BZG34_RS09750	COG0569	domain protein
BZG34_RS09785	COG0351	phosphomethylpyrimidine kinase
BZG34_RS09865	COG3617	BRO family, N-terminal domain
BZG34_RS09895	COG2350	Protein conserved in bacteria
BZG34_RS09920	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
BZG34_RS09935	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BZG34_RS10000	COG0142	geranyltranstransferase activity
BZG34_RS10060	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
BZG34_RS10070	COG0739	heme binding
BZG34_RS10110	COG1981	membrane
BZG34_RS10115	COG2954	triphosphatase activity
BZG34_RS10125	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BZG34_RS10205	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BZG34_RS10230	COG2259	Doxx family
BZG34_RS10235	COG0583	DNA-binding transcription factor activity
BZG34_RS10240	COG0415	Belongs to the DNA photolyase family
BZG34_RS10245	COG1199	ATP-dependent helicase activity
BZG34_RS10260	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
BZG34_RS10280	COG0557	exoribonuclease II activity
BZG34_RS10290	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BZG34_RS10305	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BZG34_RS10325	COG0514	ATP-dependent DNA helicase (RecQ)
BZG34_RS10340	COG2226	methyltransferase
BZG34_RS10350	COG1040	competence protein
BZG34_RS10355	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BZG34_RS10385	COG1132	(ABC) transporter
BZG34_RS10400	COG0142	geranyltranstransferase activity
BZG34_RS10475	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
BZG34_RS10480	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
BZG34_RS10500	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BZG34_RS10520	COG3676	manually curated
BZG34_RS10620	COG1546	Belongs to the CinA family
BZG34_RS10650	COG2824	Alkylphosphonate utilization operon protein PhnA
BZG34_RS10760	COG3842	ATPase activity
BZG34_RS10765	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BZG34_RS10780	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
BZG34_RS10785	COG1793	dna ligase
BZG34_RS10790	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BZG34_RS10800	COG2857	Cytochrome c1
BZG34_RS10805	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BZG34_RS10810	COG0723	plastoquinol--plastocyanin reductase activity
BZG34_RS10820	COG0583	DNA-binding transcription factor activity
BZG34_RS10870	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BZG34_RS10890	COG2056	Na+-H+ antiporter family
BZG34_RS10900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BZG34_RS10905	COG1126	abc transporter atp-binding protein
BZG34_RS10915	COG0765	amino acid transport
BZG34_RS10920	COG0312	modulator of DNA gyrase
BZG34_RS10980	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
BZG34_RS11035	COG0708	Exodeoxyribonuclease III
BZG34_RS11065	COG3038	cytochrome b561
BZG34_RS11095	COG0024	Methionine aminopeptidase
BZG34_RS11240	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
BZG34_RS11240	COG0616	signal peptide processing
BZG34_RS11245	COG1058	Belongs to the CinA family
BZG34_RS11245	COG1546	Belongs to the CinA family
BZG34_RS11300	COG0729	surface antigen
BZG34_RS11310	COG3104	oligopeptide transport
BZG34_RS11335	COG2259	Doxx family
BZG34_RS11350	COG3219	Protein conserved in bacteria
BZG34_RS11355	COG1595	DNA-templated transcription, initiation
BZG34_RS11395	COG1739	Uncharacterized protein family UPF0029
BZG34_RS11410	COG0859	PFAM glycosyl transferase family 9
BZG34_RS11415	COG1335	isochorismatase
BZG34_RS11465	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BZG34_RS11475	COG2884	Cell division ATP-binding protein ftsE
BZG34_RS11505	COG0861	Integral membrane protein TerC family
BZG34_RS11515	COG1519	Transferase
BZG34_RS11520	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
BZG34_RS11560	COG1289	transmembrane transporter activity
BZG34_RS11585	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BZG34_RS11660	COG1297	OPT oligopeptide transporter protein
BZG34_RS11715	COG0786	glutamate:sodium symporter activity
BZG34_RS11745	COG0469	pyruvate kinase activity
BZG34_RS11840	COG1652	LysM domain
BZG34_RS11870	COG5000	phosphorelay sensor kinase activity
BZG34_RS11875	COG2204	response regulator
BZG34_RS11880	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BZG34_RS11880	COG0758	DNA mediated transformation
BZG34_RS11905	COG0742	ribosomal rna small subunit methyltransferase
BZG34_RS11910	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
BZG34_RS11940	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BZG34_RS12145	COG0201	protein transport
BZG34_RS12155	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BZG34_RS12260	COG1115	amino acid carrier protein
BZG34_RS12360	COG1192	Involved in chromosome partitioning
BZG34_RS12375	COG1115	amino acid carrier protein
BZG34_RS12385	COG1530	ribonuclease E activity
BZG34_RS12435	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BZG34_RS12480	COG1760	l-serine dehydratase
BZG34_RS12500	COG0339	signal peptide processing
BZG34_RS12510	COG1858	cytochrome C peroxidase
BZG34_RS12525	COG0753	catalase activity
BZG34_RS12555	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BZG34_RS12590	COG0210	DNA helicase
BZG34_RS12635	COG1368	sulfuric ester hydrolase activity
BZG34_RS12645	COG0814	amino acid
BZG34_RS12665	COG3265	gluconokinase activity
BZG34_RS12680	COG0288	reversible hydration of carbon dioxide
BZG34_RS12690	COG0799	negative regulation of ribosome biogenesis
BZG34_RS12720	COG3676	manually curated
BZG34_RS12725	COG4604	ABC transporter, ATP-binding protein
BZG34_RS12735	COG4605	iron ion homeostasis
BZG34_RS12740	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BZG34_RS12775	COG0733	neurotransmitter:sodium symporter activity
BZG34_RS12805	COG4316	Uncharacterized protein conserved in bacteria (DUF2251)
BZG34_RS12875	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BZG34_RS12875	COG0512	Glutamine amidotransferase of anthranilate synthase
BZG34_RS12885	COG1012	belongs to the aldehyde dehydrogenase family
BZG34_RS12905	COG1127	ABC transporter
BZG34_RS12910	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BZG34_RS12915	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BZG34_RS12920	COG2854	intermembrane phospholipid transfer
BZG34_RS12940	COG0824	Thioesterase
BZG34_RS12980	COG0625	glutathione transferase activity
BZG34_RS12985	COG2969	positive regulation of protein catabolic process
BZG34_RS12990	COG1610	YqeY-like protein
BZG34_RS13010	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BZG34_RS13015	COG2011	ABC-type metal ion transport system permease component
BZG34_RS13020	COG1464	Belongs to the NlpA lipoprotein family
BZG34_RS13055	COG0356	it plays a direct role in the translocation of protons across the membrane
BZG34_RS13115	COG1442	glycosyl transferase family 8
BZG34_RS13120	COG1216	Glycosyl transferase, family 2
BZG34_RS13125	COG1216	Glycosyl transferase, family 2
BZG34_RS13140	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BZG34_RS13145	COG0483	inositol monophosphate 1-phosphatase activity
BZG34_RS13160	COG1028	Short-chain dehydrogenase reductase Sdr
BZG34_RS13175	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BZG34_RS13225	COG1399	metal-binding, possibly nucleic acid-binding protein