locus-tag	class	description
G4V53_RS00085	COG1956	GAF domain-containing protein
G4V53_RS00090	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
G4V53_RS00095	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
G4V53_RS00120	COG1505	serine-type exopeptidase activity
G4V53_RS00150	COG1214	PFAM Peptidase M22, glycoprotease
G4V53_RS00220	COG0439	Biotin carboxylase
G4V53_RS00225	COG0511	ligase activity, forming carbon-carbon bonds
G4V53_RS00255	COG2852	Protein conserved in bacteria
G4V53_RS00280	COG0489	protein tyrosine kinase activity
G4V53_RS00290	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G4V53_RS00320	COG0012	GTP binding
G4V53_RS00345	COG0196	riboflavin kinase activity
G4V53_RS00415	COG0613	PHP domain protein
G4V53_RS00420	COG3977	Valine--pyruvate aminotransferase
G4V53_RS00430	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
G4V53_RS00435	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
G4V53_RS00455	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
G4V53_RS00455	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
G4V53_RS00465	COG0121	glutamine amidotransferase
G4V53_RS00520	COG1333	cytochrome c biogenesis protein
G4V53_RS00525	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
G4V53_RS00550	COG0431	NADPH-dependent FMN reductase
G4V53_RS00555	COG2851	Citrate transporter
G4V53_RS00570	COG1530	ribonuclease E activity
G4V53_RS00585	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
G4V53_RS00665	COG0720	synthase
G4V53_RS00670	COG3759	membrane
G4V53_RS00690	COG1757	Na H antiporter
G4V53_RS00695	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
G4V53_RS00700	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
G4V53_RS00715	COG1757	Na H antiporter
G4V53_RS00760	COG0513	Belongs to the DEAD box helicase family
G4V53_RS00765	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
G4V53_RS00785	COG1560	Kdo2-lipid A biosynthetic process
G4V53_RS00795	COG0308	aminopeptidase N
G4V53_RS00800	COG3676	manually curated
G4V53_RS00835	COG0803	Belongs to the bacterial solute-binding protein 9 family
G4V53_RS00840	COG1108	ABC-type Mn2 Zn2 transport systems permease components
G4V53_RS00875	COG2205	protein histidine kinase activity
G4V53_RS00880	COG0745	RESPONSE REGULATOR receiver
G4V53_RS00900	COG0805	protein transport
G4V53_RS00925	COG1063	alcohol dehydrogenase
G4V53_RS00935	COG0123	including yeast histone deacetylase and acetoin utilization protein
G4V53_RS00940	COG1862	Preprotein translocase
G4V53_RS00945	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
G4V53_RS00950	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
G4V53_RS00960	COG3842	ATPase activity
G4V53_RS00965	COG1176	ABC-type spermidine putrescine transport system, permease component I
G4V53_RS00970	COG1177	transmembrane transport
G4V53_RS00975	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G4V53_RS00980	COG0004	ammonium transporteR
G4V53_RS00995	COG3676	manually curated
G4V53_RS01010	COG2833	Protein of unknown function (DUF455)
G4V53_RS01030	COG1216	Glycosyl transferase, family 2
G4V53_RS01035	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
G4V53_RS01080	COG1178	ABC-type Fe3 transport system permease component
G4V53_RS01100	COG1210	Utp--glucose-1-phosphate uridylyltransferase
G4V53_RS01120	COG0494	nUDIX hydrolase
G4V53_RS01180	COG0635	Involved in the biosynthesis of porphyrin-containing compound
G4V53_RS01195	COG3023	N-Acetylmuramoyl-L-alanine amidase
G4V53_RS01200	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
G4V53_RS01210	COG0280	phosphate acetyltransferase
G4V53_RS01210	COG0281	malic enzyme
G4V53_RS01260	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
G4V53_RS01335	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
G4V53_RS01350	COG0285	dihydrofolate synthase activity
G4V53_RS01365	COG1126	abc transporter atp-binding protein
G4V53_RS01435	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
G4V53_RS01440	COG1466	dna polymerase III delta subunit
G4V53_RS01455	COG1561	YicC-like family, N-terminal region
G4V53_RS01570	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
G4V53_RS01570	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
G4V53_RS01580	COG3161	chorismate lyase activity
G4V53_RS01615	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
G4V53_RS01620	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
G4V53_RS01645	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
G4V53_RS01645	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G4V53_RS01665	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
G4V53_RS01690	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
G4V53_RS01765	COG0681	Belongs to the peptidase S26 family
G4V53_RS01775	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
G4V53_RS01795	COG0084	hydrolase, TatD family'
G4V53_RS01805	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
G4V53_RS01890	COG1074	ATP-dependent DNA helicase activity
G4V53_RS01895	COG2837	iron assimilation
G4V53_RS01900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G4V53_RS01905	COG0765	amino acid transport
G4V53_RS01910	COG1126	abc transporter atp-binding protein
G4V53_RS01920	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
G4V53_RS01925	COG0471	metal ion transport
G4V53_RS01950	COG2867	negative regulation of translational initiation
G4V53_RS01955	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
G4V53_RS01975	COG0626	cystathionine gamma-synthase activity
G4V53_RS01990	COG1187	pseudouridine synthase activity
G4V53_RS02005	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
G4V53_RS02010	COG1309	transcriptional regulator
G4V53_RS02050	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
G4V53_RS02050	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
G4V53_RS02065	COG3645	SOS response
G4V53_RS02085	COG0542	response to heat
G4V53_RS02095	COG1278	Cold shock
G4V53_RS02100	COG0312	modulator of DNA gyrase
G4V53_RS02130	COG1702	phosphate starvation-inducible protein PhoH
G4V53_RS02205	COG0564	pseudouridine synthase activity
G4V53_RS02270	COG1686	Belongs to the peptidase S11 family
G4V53_RS02275	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
G4V53_RS02290	COG4208	sulfate ABC transporter
G4V53_RS02305	COG1755	Isoprenylcysteine carboxyl methyltransferase
G4V53_RS02310	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
G4V53_RS02315	COG0305	Participates in initiation and elongation during chromosome replication
G4V53_RS02360	COG0436	Aminotransferase
G4V53_RS02380	COG0582	viral genome integration into host DNA
G4V53_RS02455	COG1476	TRANSCRIPTIONal
G4V53_RS02500	COG0305	Participates in initiation and elongation during chromosome replication
G4V53_RS02545	COG5410	chromosome segregation
G4V53_RS02700	COG3676	manually curated
G4V53_RS02705	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
G4V53_RS02710	COG0318	PFAM AMP-dependent synthetase and ligase
G4V53_RS02760	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
G4V53_RS02770	COG0523	cobalamin synthesis protein
G4V53_RS02775	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
G4V53_RS02800	COG0251	oxidation-reduction process
G4V53_RS02815	COG0697	spore germination
G4V53_RS02820	COG1629	transport
G4V53_RS02820	COG4206	TonB-dependent receptor
G4V53_RS02835	COG1027	Aspartate ammonia-lyase
G4V53_RS02850	COG3676	manually curated
G4V53_RS02865	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
G4V53_RS02875	COG0508	dehydrogenase complex catalyzes the overall conversion of
G4V53_RS02880	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
G4V53_RS02890	COG0179	Fumarylacetoacetate (FAA) hydrolase
G4V53_RS02905	COG3045	CreA protein
G4V53_RS02915	COG0793	Belongs to the peptidase S41A family
G4V53_RS02955	COG2217	Heavy metal translocating P-type atpase
G4V53_RS02960	COG0492	ferredoxin-NADP+ reductase activity
G4V53_RS02985	COG0730	response to heat
G4V53_RS02990	COG1183	phosphatidylcholine synthase activity
G4V53_RS03045	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
G4V53_RS03050	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
G4V53_RS03060	COG0789	Transcriptional regulator
G4V53_RS03080	COG0733	neurotransmitter:sodium symporter activity
G4V53_RS03090	COG0741	lytic transglycosylase activity
G4V53_RS03090	COG1388	LysM domain
G4V53_RS03120	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
G4V53_RS03125	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
G4V53_RS03130	COG0633	Ferredoxin
G4V53_RS03165	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
G4V53_RS03175	COG2951	lytic endotransglycosylase activity
G4V53_RS03200	COG3036	rescue of stalled ribosome
G4V53_RS03205	COG0316	Belongs to the HesB IscA family
G4V53_RS03210	COG0822	iron-sulfur transferase activity
G4V53_RS03240	COG1304	FMN binding
G4V53_RS03245	COG3421	Type III restriction
G4V53_RS03250	COG2189	Belongs to the N(4) N(6)-methyltransferase family
G4V53_RS03255	COG2189	Belongs to the N(4) N(6)-methyltransferase family
G4V53_RS03305	COG0513	Belongs to the DEAD box helicase family
G4V53_RS03325	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
G4V53_RS03355	COG0543	2 iron, 2 sulfur cluster binding
G4V53_RS03355	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
G4V53_RS03365	COG2990	Protein conserved in bacteria
G4V53_RS03380	COG2095	MarC family integral membrane protein
G4V53_RS03385	COG1012	belongs to the aldehyde dehydrogenase family
G4V53_RS03400	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
G4V53_RS03400	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
G4V53_RS03420	COG3676	manually curated
G4V53_RS03465	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
G4V53_RS03475	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
G4V53_RS03480	COG2217	Heavy metal translocating P-type atpase
G4V53_RS03530	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
G4V53_RS03535	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
G4V53_RS03610	COG2831	hemolysin activation secretion protein
G4V53_RS03620	COG1194	a g-specific adenine glycosylase
G4V53_RS03640	COG0800	Aldolase
G4V53_RS03655	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
G4V53_RS03720	COG3676	manually curated
G4V53_RS03750	COG0210	DNA helicase
G4V53_RS03770	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
G4V53_RS03795	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
G4V53_RS03815	COG2197	response regulator
G4V53_RS03820	COG3850	Histidine kinase
G4V53_RS03830	COG0307	riboflavin synthase, alpha
G4V53_RS03845	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
G4V53_RS03865	COG0488	(ABC) transporter
G4V53_RS03870	COG1393	Belongs to the ArsC family
G4V53_RS03920	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
G4V53_RS03945	COG0488	(ABC) transporter
G4V53_RS04180	COG4453	Protein conserved in bacteria
G4V53_RS04215	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
G4V53_RS04255	COG1192	Involved in chromosome partitioning
G4V53_RS04285	COG0628	permease
G4V53_RS04330	COG0557	exoribonuclease II activity
G4V53_RS04345	COG1217	gtp-binding protein TYPA
G4V53_RS04400	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
G4V53_RS04420	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
G4V53_RS04435	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
G4V53_RS04440	COG2975	iron-sulfur cluster assembly
G4V53_RS04470	COG1562	ergosterol biosynthetic process
G4V53_RS04475	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
G4V53_RS04480	COG0300	oxidoreductase activity
G4V53_RS04510	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
G4V53_RS04525	COG2866	Carboxypeptidase
G4V53_RS04535	COG3318	Belongs to the UPF0149 family
G4V53_RS04535	COG3012	SEC-C Motif Domain Protein
G4V53_RS04595	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
G4V53_RS04620	COG2841	Protein conserved in bacteria
G4V53_RS04625	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
G4V53_RS04650	COG1476	TRANSCRIPTIONal
G4V53_RS04660	COG0586	Pfam SNARE associated Golgi protein
G4V53_RS04665	COG0488	(ABC) transporter
G4V53_RS04690	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
G4V53_RS04700	COG4150	thiosulfate binding
G4V53_RS04715	COG2801	Transposase and inactivated derivatives
G4V53_RS04720	COG2801	Transposase and inactivated derivatives
G4V53_RS04725	COG2963	transposase activity
G4V53_RS04740	COG1773	rubredoxin
G4V53_RS04760	COG0277	FAD linked oxidase domain protein
G4V53_RS04805	COG0791	NLP P60 protein
G4V53_RS04810	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
G4V53_RS04815	COG0477	Major facilitator Superfamily
G4V53_RS04820	COG0247	lactate metabolic process
G4V53_RS04830	COG1139	Iron-sulfur cluster binding protein
G4V53_RS04845	COG2801	Transposase and inactivated derivatives
G4V53_RS04850	COG2801	Transposase and inactivated derivatives
G4V53_RS04855	COG2963	transposase activity
G4V53_RS04880	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
G4V53_RS04885	COG0508	dehydrogenase complex catalyzes the overall conversion of
G4V53_RS04890	COG0567	Dehydrogenase, E1 component
G4V53_RS04905	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
G4V53_RS04930	COG0678	peroxiredoxin activity
G4V53_RS04930	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
G4V53_RS04965	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
G4V53_RS04965	COG2813	Specifically methylates the guanine in position
G4V53_RS05000	COG0590	tRNA wobble adenosine to inosine editing
G4V53_RS05070	COG0589	response to stress
G4V53_RS05075	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
G4V53_RS05080	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
G4V53_RS05105	COG0765	amino acid transport
G4V53_RS05130	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
G4V53_RS05170	COG1562	ergosterol biosynthetic process
G4V53_RS05185	COG0277	FAD linked oxidase domain protein
G4V53_RS05190	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
G4V53_RS05205	COG0859	PFAM glycosyl transferase family 9
G4V53_RS05215	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
G4V53_RS05240	COG3945	hemerythrin HHE cation binding domain
G4V53_RS05315	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
G4V53_RS05395	COG2070	2-Nitropropane dioxygenase
G4V53_RS05405	COG0348	domain, Protein
G4V53_RS05420	COG0697	spore germination
G4V53_RS05430	COG2814	Major facilitator Superfamily
G4V53_RS05490	COG0436	Aminotransferase
G4V53_RS05495	COG1942	4-Oxalocrotonate Tautomerase
G4V53_RS05525	COG1607	acyl-coa hydrolase
G4V53_RS05540	COG1253	flavin adenine dinucleotide binding
G4V53_RS05550	COG1012	belongs to the aldehyde dehydrogenase family
G4V53_RS05565	COG1966	Carbon starvation protein
G4V53_RS05575	COG3676	manually curated
G4V53_RS05665	COG3676	manually curated
G4V53_RS05690	COG1607	acyl-coa hydrolase
G4V53_RS05695	COG4221	oxidoreductase activity
G4V53_RS05730	COG3617	BRO family, N-terminal domain
G4V53_RS05815	COG1484	DNA-dependent DNA replication
G4V53_RS05820	COG4626	Terminase
G4V53_RS05820	COG1802	Transcriptional regulator
G4V53_RS06055	COG0564	pseudouridine synthase activity
G4V53_RS06060	COG0561	phosphatase activity
G4V53_RS06070	COG3676	manually curated
G4V53_RS06075	COG0347	Belongs to the P(II) protein family
G4V53_RS06090	COG0640	Transcriptional regulator
G4V53_RS06100	COG2239	Acts as a magnesium transporter
G4V53_RS06110	COG0791	NLP P60 protein
G4V53_RS06120	COG1380	Effector of murein hydrolase LrgA
G4V53_RS06125	COG1346	cytolysis
G4V53_RS06135	COG0038	chloride channel
G4V53_RS06140	COG1643	Atp-dependent helicase
G4V53_RS06155	COG1643	Atp-dependent helicase
G4V53_RS06185	COG0512	Glutamine amidotransferase of anthranilate synthase
G4V53_RS06220	COG3676	manually curated
G4V53_RS06230	COG0318	PFAM AMP-dependent synthetase and ligase
G4V53_RS06265	COG2431	L-lysine efflux transmembrane transporter activity
G4V53_RS06270	COG1802	Transcriptional regulator
G4V53_RS06275	COG1765	OsmC-like protein
G4V53_RS06285	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
G4V53_RS06320	COG1049	propionate catabolic process, 2-methylcitrate cycle
G4V53_RS06345	COG0028	Belongs to the TPP enzyme family
G4V53_RS06360	COG1999	signal sequence binding
G4V53_RS06405	COG0616	signal peptide processing
G4V53_RS06435	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
G4V53_RS06445	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
G4V53_RS06490	COG3676	manually curated
G4V53_RS06575	COG1619	proteins homologs of microcin C7 resistance protein MccF
G4V53_RS06590	COG1262	PFAM Formylglycine-generating sulfatase enzyme
G4V53_RS06610	COG0778	Nitroreductase
G4V53_RS06615	COG2194	sulfuric ester hydrolase activity
G4V53_RS06640	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
G4V53_RS06650	COG1272	protein, Hemolysin III
G4V53_RS06655	COG1115	amino acid carrier protein
G4V53_RS06715	COG3676	manually curated
G4V53_RS06760	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
G4V53_RS06765	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
G4V53_RS06785	COG0561	phosphatase activity
G4V53_RS06790	COG0826	peptidase U32
G4V53_RS06805	COG3676	manually curated
G4V53_RS06815	COG2995	paraquat-inducible protein a
G4V53_RS06820	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
G4V53_RS06820	COG3008	intermembrane lipid transfer
G4V53_RS06830	COG0519	Catalyzes the synthesis of GMP from XMP
G4V53_RS06860	COG3245	cytochrome
G4V53_RS06870	COG1448	Aminotransferase
G4V53_RS06905	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
G4V53_RS06920	COG0252	asparaginase activity
G4V53_RS06925	COG0586	Pfam SNARE associated Golgi protein
G4V53_RS06940	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
G4V53_RS06980	COG1028	Short-chain dehydrogenase reductase Sdr
G4V53_RS07010	COG0733	neurotransmitter:sodium symporter activity
G4V53_RS07035	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
G4V53_RS07045	COG2186	Transcriptional regulator
G4V53_RS07050	COG1620	l-lactate permease
G4V53_RS07085	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
G4V53_RS07090	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
G4V53_RS07100	COG2010	Cytochrome c
G4V53_RS07115	COG3278	Belongs to the heme-copper respiratory oxidase family
G4V53_RS07125	COG3453	Protein conserved in bacteria
G4V53_RS07125	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G4V53_RS07145	COG1994	Peptidase M50
G4V53_RS07150	COG2999	glutathione oxidoreductase activity
G4V53_RS07155	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
G4V53_RS07260	COG3676	manually curated
G4V53_RS07270	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
G4V53_RS07270	COG0644	oxidoreductase
G4V53_RS07280	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
G4V53_RS07325	COG1522	sequence-specific DNA binding
G4V53_RS07335	COG2832	Protein of unknown function (DUF454)
G4V53_RS07345	COG3676	manually curated
G4V53_RS07380	COG1477	protein flavinylation
G4V53_RS07385	COG2991	Protein conserved in bacteria
G4V53_RS07395	COG1045	serine acetyltransferase
G4V53_RS07455	COG1116	anion transmembrane transporter activity
G4V53_RS07470	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
G4V53_RS07475	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
G4V53_RS07485	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G4V53_RS07495	COG1064	alcohol dehydrogenase
G4V53_RS07505	COG1196	nuclear chromosome segregation
G4V53_RS07520	COG1620	l-lactate permease
G4V53_RS07535	COG1448	Aminotransferase
G4V53_RS07585	COG0560	Phosphoserine phosphatase
G4V53_RS07590	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
G4V53_RS07600	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
G4V53_RS07605	COG2249	NAD(P)H dehydrogenase (quinone) activity
G4V53_RS07610	COG0583	DNA-binding transcription factor activity
G4V53_RS07645	COG0500	methyltransferase
G4V53_RS07650	COG2830	Protein of unknown function (DUF452)
G4V53_RS07660	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
G4V53_RS07665	COG1376	ErfK ybiS ycfS ynhG family protein
G4V53_RS07670	COG0471	metal ion transport
G4V53_RS07735	COG0802	atpase or kinase
G4V53_RS07795	COG0697	spore germination
G4V53_RS07815	COG0287	Prephenate dehydrogenase
G4V53_RS07830	COG1959	2 iron, 2 sulfur cluster binding
G4V53_RS07835	COG0009	L-threonylcarbamoyladenylate synthase
G4V53_RS07860	COG0372	Belongs to the citrate synthase family
G4V53_RS07870	COG2252	PERMEase
G4V53_RS07930	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
G4V53_RS07935	COG2194	sulfuric ester hydrolase activity
G4V53_RS08000	COG2960	long-chain fatty acid transporting porin activity
G4V53_RS08035	COG0708	Exodeoxyribonuclease III
G4V53_RS08075	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
G4V53_RS08100	COG0488	(ABC) transporter
G4V53_RS08105	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
G4V53_RS08110	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
G4V53_RS08120	COG0583	DNA-binding transcription factor activity
G4V53_RS08125	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
G4V53_RS08130	COG0635	Involved in the biosynthesis of porphyrin-containing compound
G4V53_RS08225	COG2814	Major facilitator Superfamily
G4V53_RS08255	COG1137	ATPase activity
G4V53_RS08260	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
G4V53_RS08270	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
G4V53_RS08395	COG1484	DNA-dependent DNA replication
G4V53_RS08510	COG0569	domain protein
G4V53_RS08525	COG3676	manually curated
G4V53_RS08545	COG0351	phosphomethylpyrimidine kinase
G4V53_RS08620	COG3617	BRO family, N-terminal domain
G4V53_RS08650	COG2350	Protein conserved in bacteria
G4V53_RS08670	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
G4V53_RS08680	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
G4V53_RS08740	COG0142	geranyltranstransferase activity
G4V53_RS08790	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
G4V53_RS08795	COG0739	heme binding
G4V53_RS08820	COG1981	membrane
G4V53_RS08825	COG2954	triphosphatase activity
G4V53_RS08835	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
G4V53_RS08900	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
G4V53_RS08925	COG2259	Doxx family
G4V53_RS08930	COG0583	DNA-binding transcription factor activity
G4V53_RS08935	COG0415	Belongs to the DNA photolyase family
G4V53_RS08940	COG1199	ATP-dependent helicase activity
G4V53_RS08950	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
G4V53_RS08965	COG0557	exoribonuclease II activity
G4V53_RS08970	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
G4V53_RS08985	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
G4V53_RS09005	COG0514	ATP-dependent DNA helicase (RecQ)
G4V53_RS09020	COG2226	methyltransferase
G4V53_RS09030	COG1040	competence protein
G4V53_RS09035	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
G4V53_RS09060	COG1132	(ABC) transporter
G4V53_RS09080	COG0142	geranyltranstransferase activity
G4V53_RS09155	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
G4V53_RS09160	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
G4V53_RS09180	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G4V53_RS09195	COG3676	manually curated
G4V53_RS09205	COG0210	DNA helicase
G4V53_RS09235	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
G4V53_RS09255	COG0753	catalase activity
G4V53_RS09265	COG1858	cytochrome C peroxidase
G4V53_RS09270	COG0339	signal peptide processing
G4V53_RS09285	COG1760	l-serine dehydratase
G4V53_RS09325	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
G4V53_RS09380	COG1530	ribonuclease E activity
G4V53_RS09390	COG1115	amino acid carrier protein
G4V53_RS09405	COG1192	Involved in chromosome partitioning
G4V53_RS09500	COG1115	amino acid carrier protein
G4V53_RS09580	COG0257	Belongs to the bacterial ribosomal protein bL36 family
G4V53_RS09590	COG0201	protein transport
G4V53_RS09795	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
G4V53_RS09825	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
G4V53_RS09830	COG0742	ribosomal rna small subunit methyltransferase
G4V53_RS09860	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
G4V53_RS09860	COG0758	DNA mediated transformation
G4V53_RS09865	COG2204	response regulator
G4V53_RS09870	COG5000	phosphorelay sensor kinase activity
G4V53_RS09900	COG1652	LysM domain
G4V53_RS09945	COG0469	pyruvate kinase activity
G4V53_RS09980	COG0786	glutamate:sodium symporter activity
G4V53_RS10035	COG1297	OPT oligopeptide transporter protein
G4V53_RS10085	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
G4V53_RS10110	COG1289	transmembrane transporter activity
G4V53_RS10130	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
G4V53_RS10135	COG1519	Transferase
G4V53_RS10145	COG0861	Integral membrane protein TerC family
G4V53_RS10175	COG2884	Cell division ATP-binding protein ftsE
G4V53_RS10180	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G4V53_RS10225	COG1335	isochorismatase
G4V53_RS10230	COG0859	PFAM glycosyl transferase family 9
G4V53_RS10245	COG1739	Uncharacterized protein family UPF0029
G4V53_RS10280	COG1595	DNA-templated transcription, initiation
G4V53_RS10285	COG3219	Protein conserved in bacteria
G4V53_RS10300	COG2259	Doxx family
G4V53_RS10320	COG3104	oligopeptide transport
G4V53_RS10330	COG0729	surface antigen
G4V53_RS10370	COG1058	Belongs to the CinA family
G4V53_RS10370	COG1546	Belongs to the CinA family
G4V53_RS10375	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
G4V53_RS10375	COG0616	signal peptide processing
G4V53_RS10510	COG0024	Methionine aminopeptidase
G4V53_RS10540	COG3038	cytochrome b561
G4V53_RS10565	COG0708	Exodeoxyribonuclease III
G4V53_RS10610	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
G4V53_RS10655	COG0312	modulator of DNA gyrase
G4V53_RS10660	COG0765	amino acid transport
G4V53_RS10670	COG1126	abc transporter atp-binding protein
G4V53_RS10675	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G4V53_RS10685	COG2056	Na+-H+ antiporter family
G4V53_RS10695	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
G4V53_RS10740	COG0583	DNA-binding transcription factor activity
G4V53_RS10750	COG0723	plastoquinol--plastocyanin reductase activity
G4V53_RS10755	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
G4V53_RS10760	COG2857	Cytochrome c1
G4V53_RS10770	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G4V53_RS10775	COG1793	dna ligase
G4V53_RS10780	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
G4V53_RS10795	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
G4V53_RS10800	COG3842	ATPase activity
G4V53_RS10875	COG2824	Alkylphosphonate utilization operon protein PhnA
G4V53_RS10905	COG1546	Belongs to the CinA family
G4V53_RS11010	COG1368	sulfuric ester hydrolase activity
G4V53_RS11020	COG0814	amino acid
G4V53_RS11035	COG3265	gluconokinase activity
G4V53_RS11040	COG2610	gluconate transmembrane transporter activity
G4V53_RS11055	COG0288	reversible hydration of carbon dioxide
G4V53_RS11065	COG0799	negative regulation of ribosome biogenesis
G4V53_RS11100	COG4604	ABC transporter, ATP-binding protein
G4V53_RS11110	COG4605	iron ion homeostasis
G4V53_RS11115	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G4V53_RS11145	COG0733	neurotransmitter:sodium symporter activity
G4V53_RS11175	COG4316	Uncharacterized protein conserved in bacteria (DUF2251)
G4V53_RS11225	COG0512	Glutamine amidotransferase of anthranilate synthase
G4V53_RS11225	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
G4V53_RS11235	COG1012	belongs to the aldehyde dehydrogenase family
G4V53_RS11250	COG1127	ABC transporter
G4V53_RS11255	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
G4V53_RS11260	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
G4V53_RS11265	COG2854	intermembrane phospholipid transfer
G4V53_RS11285	COG0824	Thioesterase
G4V53_RS11330	COG0625	glutathione transferase activity
G4V53_RS11335	COG2969	positive regulation of protein catabolic process
G4V53_RS11345	COG1610	YqeY-like protein
G4V53_RS11365	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
G4V53_RS11370	COG2011	ABC-type metal ion transport system permease component
G4V53_RS11375	COG1464	Belongs to the NlpA lipoprotein family
G4V53_RS11400	COG0356	it plays a direct role in the translocation of protons across the membrane
G4V53_RS11460	COG1442	glycosyl transferase family 8
G4V53_RS11475	COG1385	rRNA (uridine-N3-)-methyltransferase activity
G4V53_RS11480	COG0483	inositol monophosphate 1-phosphatase activity
G4V53_RS11490	COG1028	Short-chain dehydrogenase reductase Sdr
G4V53_RS11505	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
G4V53_RS11555	COG1399	metal-binding, possibly nucleic acid-binding protein
G4V53_RS11635	COG0629	single-stranded DNA binding
G4V53_RS11645	COG4962	Type ii secretion system protein e
G4V53_RS11650	COG3838	Conjugal transfer protein Trbc
G4V53_RS11660	COG3451	type IV secretory pathway VirB4
G4V53_RS11665	COG3701	Conjugal transfer protein
G4V53_RS11670	COG3504	Conjugal transfer protein
G4V53_RS11680	COG2948	multi-organism process
G4V53_RS11785	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone