locus-tag	class	description
A6J51_RS00010	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
A6J51_RS00025	COG0385	Bile acid
A6J51_RS00070	COG1126	abc transporter atp-binding protein
A6J51_RS00085	COG0285	dihydrofolate synthase activity
A6J51_RS00100	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
A6J51_RS00185	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
A6J51_RS00235	COG0280	phosphate acetyltransferase
A6J51_RS00235	COG0281	malic enzyme
A6J51_RS00245	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A6J51_RS00250	COG3023	N-Acetylmuramoyl-L-alanine amidase
A6J51_RS00270	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A6J51_RS00425	COG0494	nUDIX hydrolase
A6J51_RS00445	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A6J51_RS00470	COG1178	ABC-type Fe3 transport system permease component
A6J51_RS00480	COG0280	phosphate acetyltransferase
A6J51_RS00480	COG0857	belongs to the CobB CobQ family
A6J51_RS00520	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
A6J51_RS00530	COG0463	Glycosyl transferase, family 2
A6J51_RS00555	COG2833	Protein of unknown function (DUF455)
A6J51_RS00585	COG3676	manually curated
A6J51_RS00600	COG0004	ammonium transporteR
A6J51_RS00605	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A6J51_RS00610	COG1177	transmembrane transport
A6J51_RS00615	COG1176	ABC-type spermidine putrescine transport system, permease component I
A6J51_RS00620	COG3842	ATPase activity
A6J51_RS00630	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A6J51_RS00635	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A6J51_RS00640	COG1862	Preprotein translocase
A6J51_RS00645	COG0123	including yeast histone deacetylase and acetoin utilization protein
A6J51_RS00650	COG1063	alcohol dehydrogenase
A6J51_RS00675	COG0805	protein transport
A6J51_RS00695	COG0745	RESPONSE REGULATOR receiver
A6J51_RS00700	COG2205	protein histidine kinase activity
A6J51_RS00735	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A6J51_RS00740	COG0803	Belongs to the bacterial solute-binding protein 9 family
A6J51_RS00780	COG3676	manually curated
A6J51_RS00790	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
A6J51_RS00790	COG0644	oxidoreductase
A6J51_RS00845	COG1522	sequence-specific DNA binding
A6J51_RS00855	COG2832	Protein of unknown function (DUF454)
A6J51_RS00900	COG1477	protein flavinylation
A6J51_RS00905	COG2991	Protein conserved in bacteria
A6J51_RS00915	COG1045	serine acetyltransferase
A6J51_RS00975	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A6J51_RS00980	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A6J51_RS00995	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6J51_RS01005	COG1064	alcohol dehydrogenase
A6J51_RS01015	COG1196	nuclear chromosome segregation
A6J51_RS01025	COG1620	l-lactate permease
A6J51_RS01040	COG1448	Aminotransferase
A6J51_RS01065	COG1757	Na H antiporter
A6J51_RS01095	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A6J51_RS01100	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A6J51_RS01105	COG1757	Na H antiporter
A6J51_RS01125	COG3759	membrane
A6J51_RS01130	COG0720	synthase
A6J51_RS01190	COG3210	domain, Protein
A6J51_RS01220	COG3210	domain, Protein
A6J51_RS01225	COG2831	hemolysin activation secretion protein
A6J51_RS01285	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A6J51_RS01300	COG1530	ribonuclease E activity
A6J51_RS01315	COG2851	Citrate transporter
A6J51_RS01320	COG0431	NADPH-dependent FMN reductase
A6J51_RS01430	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A6J51_RS01435	COG1333	cytochrome c biogenesis protein
A6J51_RS01515	COG0121	glutamine amidotransferase
A6J51_RS01525	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A6J51_RS01525	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A6J51_RS01545	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A6J51_RS01555	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A6J51_RS01565	COG3977	Valine--pyruvate aminotransferase
A6J51_RS01570	COG0613	PHP domain protein
A6J51_RS01645	COG0196	riboflavin kinase activity
A6J51_RS01665	COG0012	GTP binding
A6J51_RS01700	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A6J51_RS01710	COG0489	protein tyrosine kinase activity
A6J51_RS01790	COG2852	Protein conserved in bacteria
A6J51_RS01815	COG0583	DNA-binding transcription factor activity
A6J51_RS01825	COG2249	NAD(P)H dehydrogenase (quinone) activity
A6J51_RS01845	COG0511	ligase activity, forming carbon-carbon bonds
A6J51_RS01850	COG0439	Biotin carboxylase
A6J51_RS01900	COG1214	PFAM Peptidase M22, glycoprotease
A6J51_RS01930	COG1505	serine-type exopeptidase activity
A6J51_RS01975	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A6J51_RS01980	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
A6J51_RS01985	COG1956	GAF domain-containing protein
A6J51_RS02035	COG0338	D12 class N6 adenine-specific DNA methyltransferase
A6J51_RS02160	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A6J51_RS02175	COG1028	Short-chain dehydrogenase reductase Sdr
A6J51_RS02190	COG1943	Transposase
A6J51_RS02235	COG1199	ATP-dependent helicase activity
A6J51_RS02245	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
A6J51_RS02255	COG1611	Belongs to the LOG family
A6J51_RS02260	COG0557	exoribonuclease II activity
A6J51_RS02285	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A6J51_RS02300	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A6J51_RS02325	COG0514	ATP-dependent DNA helicase (RecQ)
A6J51_RS02345	COG2226	methyltransferase
A6J51_RS02355	COG1040	competence protein
A6J51_RS02360	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
A6J51_RS02385	COG1132	(ABC) transporter
A6J51_RS02400	COG0142	geranyltranstransferase activity
A6J51_RS02465	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
A6J51_RS02470	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
A6J51_RS02490	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A6J51_RS02495	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
A6J51_RS02505	COG3676	manually curated
A6J51_RS02530	COG0210	DNA helicase
A6J51_RS02540	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
A6J51_RS02545	COG1984	allophanate hydrolase subunit 2
A6J51_RS02555	COG1914	H( )-stimulated, divalent metal cation uptake system
A6J51_RS02610	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A6J51_RS02615	COG0385	Bile acid
A6J51_RS02635	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
A6J51_RS02640	COG0753	catalase activity
A6J51_RS02670	COG1943	Transposase
A6J51_RS02680	COG0339	signal peptide processing
A6J51_RS02700	COG1760	l-serine dehydratase
A6J51_RS02705	COG1760	l-serine dehydratase
A6J51_RS02750	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A6J51_RS02790	COG0564	pseudouridine synthase activity
A6J51_RS02800	COG1530	ribonuclease E activity
A6J51_RS02810	COG1115	amino acid carrier protein
A6J51_RS02830	COG1192	Involved in chromosome partitioning
A6J51_RS02910	COG1115	amino acid carrier protein
A6J51_RS02990	COG0201	protein transport
A6J51_RS03180	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A6J51_RS03210	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
A6J51_RS03215	COG0742	ribosomal rna small subunit methyltransferase
A6J51_RS03220	COG1476	TRANSCRIPTIONal
A6J51_RS03245	COG0758	DNA mediated transformation
A6J51_RS03245	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A6J51_RS03250	COG2204	response regulator
A6J51_RS03255	COG5000	phosphorelay sensor kinase activity
A6J51_RS03280	COG1652	LysM domain
A6J51_RS03330	COG0469	pyruvate kinase activity
A6J51_RS03355	COG0786	glutamate:sodium symporter activity
A6J51_RS03410	COG2089	acid synthase
A6J51_RS03480	COG1297	OPT oligopeptide transporter protein
A6J51_RS03495	COG1555	photosystem II stabilization
A6J51_RS03495	COG1596	polysaccharide export
A6J51_RS03540	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A6J51_RS03565	COG1289	transmembrane transporter activity
A6J51_RS03680	COG1546	Belongs to the CinA family
A6J51_RS03710	COG2824	Alkylphosphonate utilization operon protein PhnA
A6J51_RS03730	COG0672	)-iron permease
A6J51_RS03760	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A6J51_RS03825	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
A6J51_RS03830	COG1519	Transferase
A6J51_RS03840	COG0861	Integral membrane protein TerC family
A6J51_RS03875	COG2884	Cell division ATP-binding protein ftsE
A6J51_RS03885	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A6J51_RS03935	COG1335	isochorismatase
A6J51_RS03940	COG0859	PFAM glycosyl transferase family 9
A6J51_RS03955	COG1739	Uncharacterized protein family UPF0029
A6J51_RS04000	COG1595	DNA-templated transcription, initiation
A6J51_RS04005	COG3219	Protein conserved in bacteria
A6J51_RS04020	COG2259	Doxx family
A6J51_RS04025	COG4667	esterase of the alpha-beta hydrolase superfamily
A6J51_RS04045	COG3104	oligopeptide transport
A6J51_RS04060	COG0729	surface antigen
A6J51_RS04100	COG1546	Belongs to the CinA family
A6J51_RS04100	COG1058	Belongs to the CinA family
A6J51_RS04105	COG0616	signal peptide processing
A6J51_RS04255	COG3038	cytochrome b561
A6J51_RS04285	COG0708	Exodeoxyribonuclease III
A6J51_RS04335	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A6J51_RS04385	COG0312	modulator of DNA gyrase
A6J51_RS04400	COG2056	Na+-H+ antiporter family
A6J51_RS04415	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A6J51_RS04455	COG0583	DNA-binding transcription factor activity
A6J51_RS04465	COG0723	plastoquinol--plastocyanin reductase activity
A6J51_RS04470	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
A6J51_RS04475	COG2857	Cytochrome c1
A6J51_RS04485	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A6J51_RS04490	COG1793	dna ligase
A6J51_RS04495	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
A6J51_RS04510	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A6J51_RS04535	COG3842	ATPase activity
A6J51_RS04650	COG1368	sulfuric ester hydrolase activity
A6J51_RS04660	COG0814	amino acid
A6J51_RS04675	COG3265	gluconokinase activity
A6J51_RS04680	COG2610	gluconate transmembrane transporter activity
A6J51_RS04690	COG0288	reversible hydration of carbon dioxide
A6J51_RS04700	COG0799	negative regulation of ribosome biogenesis
A6J51_RS04725	COG0564	pseudouridine synthase activity
A6J51_RS04800	COG1643	Atp-dependent helicase
A6J51_RS04815	COG1643	Atp-dependent helicase
A6J51_RS04820	COG0038	chloride channel
A6J51_RS04830	COG1346	cytolysis
A6J51_RS04835	COG1380	Effector of murein hydrolase LrgA
A6J51_RS04850	COG0791	NLP P60 protein
A6J51_RS04865	COG2239	Acts as a magnesium transporter
A6J51_RS04890	COG0347	Belongs to the P(II) protein family
A6J51_RS04895	COG4604	ABC transporter, ATP-binding protein
A6J51_RS04905	COG4605	iron ion homeostasis
A6J51_RS04910	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A6J51_RS04975	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A6J51_RS04975	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A6J51_RS04985	COG4316	Uncharacterized protein conserved in bacteria (DUF2251)
A6J51_RS05015	COG0733	neurotransmitter:sodium symporter activity
A6J51_RS05060	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A6J51_RS05060	COG0512	Glutamine amidotransferase of anthranilate synthase
A6J51_RS05075	COG1012	belongs to the aldehyde dehydrogenase family
A6J51_RS05105	COG1127	ABC transporter
A6J51_RS05110	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A6J51_RS05115	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
A6J51_RS05120	COG2854	intermembrane phospholipid transfer
A6J51_RS05140	COG0824	Thioesterase
A6J51_RS05175	COG0625	glutathione transferase activity
A6J51_RS05180	COG2969	positive regulation of protein catabolic process
A6J51_RS05190	COG1610	YqeY-like protein
A6J51_RS05205	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A6J51_RS05210	COG2011	ABC-type metal ion transport system permease component
A6J51_RS05215	COG1464	Belongs to the NlpA lipoprotein family
A6J51_RS05250	COG0356	it plays a direct role in the translocation of protons across the membrane
A6J51_RS05305	COG1216	Glycosyl transferase, family 2
A6J51_RS05335	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A6J51_RS05340	COG0483	inositol monophosphate 1-phosphatase activity
A6J51_RS05355	COG3012	SEC-C Motif Domain Protein
A6J51_RS05375	COG0583	DNA-binding transcription factor activity
A6J51_RS05380	COG2259	Doxx family
A6J51_RS05400	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A6J51_RS05405	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A6J51_RS05450	COG1555	photosystem II stabilization
A6J51_RS05450	COG1596	polysaccharide export
A6J51_RS05480	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A6J51_RS05495	COG2954	triphosphatase activity
A6J51_RS05500	COG1981	membrane
A6J51_RS05545	COG0739	heme binding
A6J51_RS05550	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
A6J51_RS05610	COG0142	geranyltranstransferase activity
A6J51_RS05670	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A6J51_RS05680	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
A6J51_RS05705	COG2350	Protein conserved in bacteria
A6J51_RS05730	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A6J51_RS05755	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
A6J51_RS05765	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
A6J51_RS05770	COG1137	ATPase activity
A6J51_RS05810	COG2814	Major facilitator Superfamily
A6J51_RS05895	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A6J51_RS05900	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A6J51_RS05905	COG0583	DNA-binding transcription factor activity
A6J51_RS05930	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
A6J51_RS05935	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
A6J51_RS05940	COG0488	(ABC) transporter
A6J51_RS05950	COG2017	converts alpha-aldose to the beta-anomer
A6J51_RS05960	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A6J51_RS05990	COG0640	Transcriptional regulator
A6J51_RS05995	COG0708	Exodeoxyribonuclease III
A6J51_RS06005	COG3547	Transposase (IS116 IS110 IS902 family)
A6J51_RS06045	COG0606	chelatase, subunit chli
A6J51_RS06110	COG2194	sulfuric ester hydrolase activity
A6J51_RS06115	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A6J51_RS06190	COG2252	PERMEase
A6J51_RS06205	COG0372	Belongs to the citrate synthase family
A6J51_RS06220	COG2828	Protein conserved in bacteria
A6J51_RS06230	COG0009	L-threonylcarbamoyladenylate synthase
A6J51_RS06235	COG1959	2 iron, 2 sulfur cluster binding
A6J51_RS06255	COG0287	Prephenate dehydrogenase
A6J51_RS06260	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A6J51_RS06305	COG0697	spore germination
A6J51_RS06310	COG2814	Major facilitator Superfamily
A6J51_RS06385	COG0802	atpase or kinase
A6J51_RS06500	COG0471	metal ion transport
A6J51_RS06505	COG1376	ErfK ybiS ycfS ynhG family protein
A6J51_RS06510	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A6J51_RS06520	COG2830	Protein of unknown function (DUF452)
A6J51_RS06525	COG0500	methyltransferase
A6J51_RS06610	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6J51_RS06615	COG1538	Outer membrane efflux protein
A6J51_RS06630	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A6J51_RS06640	COG2999	glutathione oxidoreductase activity
A6J51_RS06665	COG1994	Peptidase M50
A6J51_RS06685	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A6J51_RS06685	COG3453	Protein conserved in bacteria
A6J51_RS06695	COG3278	Belongs to the heme-copper respiratory oxidase family
A6J51_RS06710	COG2010	Cytochrome c
A6J51_RS06725	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
A6J51_RS06730	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
A6J51_RS06770	COG1620	l-lactate permease
A6J51_RS06790	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A6J51_RS06810	COG0733	neurotransmitter:sodium symporter activity
A6J51_RS06840	COG3676	manually curated
A6J51_RS06875	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
A6J51_RS06890	COG0586	Pfam SNARE associated Golgi protein
A6J51_RS06895	COG0252	asparaginase activity
A6J51_RS06910	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A6J51_RS06955	COG3245	cytochrome
A6J51_RS06990	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
A6J51_RS06990	COG3008	intermembrane lipid transfer
A6J51_RS06995	COG2995	paraquat-inducible protein a
A6J51_RS07030	COG0826	peptidase U32
A6J51_RS07035	COG0561	phosphatase activity
A6J51_RS07055	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A6J51_RS07060	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A6J51_RS07100	COG1596	polysaccharide export
A6J51_RS07100	COG1555	photosystem II stabilization
A6J51_RS07165	COG1115	amino acid carrier protein
A6J51_RS07170	COG1272	protein, Hemolysin III
A6J51_RS07180	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
A6J51_RS07210	COG2194	sulfuric ester hydrolase activity
A6J51_RS07215	COG0778	Nitroreductase
A6J51_RS07240	COG1262	PFAM Formylglycine-generating sulfatase enzyme
A6J51_RS07260	COG1619	proteins homologs of microcin C7 resistance protein MccF
A6J51_RS07305	COG0351	phosphomethylpyrimidine kinase
A6J51_RS07335	COG0569	domain protein
A6J51_RS07340	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
A6J51_RS07340	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
A6J51_RS07405	COG5002	protein histidine kinase activity
A6J51_RS07425	COG1275	C4-dicarboxylate transporter malic acid transport protein
A6J51_RS07490	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A6J51_RS07500	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A6J51_RS07535	COG0616	signal peptide processing
A6J51_RS07565	COG2084	Dehydrogenase
A6J51_RS07595	COG1999	signal sequence binding
A6J51_RS07605	COG0028	Belongs to the TPP enzyme family
A6J51_RS07630	COG1049	propionate catabolic process, 2-methylcitrate cycle
A6J51_RS07660	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A6J51_RS07670	COG1765	OsmC-like protein
A6J51_RS07680	COG1802	Transcriptional regulator
A6J51_RS07685	COG2431	L-lysine efflux transmembrane transporter activity
A6J51_RS07690	COG1349	DNA-binding transcription factor activity
A6J51_RS07730	COG0318	PFAM AMP-dependent synthetase and ligase
A6J51_RS07855	COG3945	hemerythrin HHE cation binding domain
A6J51_RS07880	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A6J51_RS07890	COG0859	PFAM glycosyl transferase family 9
A6J51_RS07900	COG0470	DNA polymerase III
A6J51_RS07910	COG0277	FAD linked oxidase domain protein
A6J51_RS07930	COG1562	ergosterol biosynthetic process
A6J51_RS07995	COG0765	amino acid transport
A6J51_RS08035	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
A6J51_RS08045	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
A6J51_RS08095	COG1966	Carbon starvation protein
A6J51_RS08140	COG1253	flavin adenine dinucleotide binding
A6J51_RS08160	COG1607	acyl-coa hydrolase
A6J51_RS08200	COG1942	4-Oxalocrotonate Tautomerase
A6J51_RS08205	COG0436	Aminotransferase
A6J51_RS08320	COG1943	Transposase
A6J51_RS08345	COG0739	heme binding
A6J51_RS08345	COG1196	nuclear chromosome segregation
A6J51_RS08345	COG0741	lytic transglycosylase activity
A6J51_RS08350	COG2814	Major facilitator Superfamily
A6J51_RS08365	COG0697	spore germination
A6J51_RS08375	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
A6J51_RS08390	COG0348	domain, Protein
A6J51_RS08400	COG2070	2-Nitropropane dioxygenase
A6J51_RS08440	COG0210	DNA helicase
A6J51_RS08510	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A6J51_RS08535	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
A6J51_RS08545	COG1139	Iron-sulfur cluster binding protein
A6J51_RS08555	COG0247	lactate metabolic process
A6J51_RS08560	COG0477	Major facilitator Superfamily
A6J51_RS08565	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A6J51_RS08570	COG0791	NLP P60 protein
A6J51_RS08645	COG0513	Belongs to the DEAD box helicase family
A6J51_RS08650	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A6J51_RS08680	COG0308	aminopeptidase N
A6J51_RS08730	COG1194	a g-specific adenine glycosylase
A6J51_RS08740	COG1063	alcohol dehydrogenase
A6J51_RS08750	COG0800	Aldolase
A6J51_RS08760	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A6J51_RS08780	COG1737	Transcriptional regulator
A6J51_RS08820	COG3036	rescue of stalled ribosome
A6J51_RS08830	COG0822	iron-sulfur transferase activity
A6J51_RS08845	COG1304	FMN binding
A6J51_RS08850	COG3421	Type III restriction
A6J51_RS08855	COG2189	Belongs to the N(4) N(6)-methyltransferase family
A6J51_RS08900	COG0513	Belongs to the DEAD box helicase family
A6J51_RS08930	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
A6J51_RS08965	COG0543	2 iron, 2 sulfur cluster binding
A6J51_RS08965	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A6J51_RS08975	COG2990	Protein conserved in bacteria
A6J51_RS08990	COG2095	MarC family integral membrane protein
A6J51_RS08995	COG1012	belongs to the aldehyde dehydrogenase family
A6J51_RS09005	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A6J51_RS09005	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A6J51_RS09020	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
A6J51_RS09045	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A6J51_RS09050	COG0508	dehydrogenase complex catalyzes the overall conversion of
A6J51_RS09055	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
A6J51_RS09070	COG0179	Fumarylacetoacetate (FAA) hydrolase
A6J51_RS09085	COG3045	CreA protein
A6J51_RS09100	COG0793	Belongs to the peptidase S41A family
A6J51_RS09135	COG2217	Heavy metal translocating P-type atpase
A6J51_RS09140	COG0492	ferredoxin-NADP+ reductase activity
A6J51_RS09165	COG0730	response to heat
A6J51_RS09170	COG1183	phosphatidylcholine synthase activity
A6J51_RS09230	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
A6J51_RS09240	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
A6J51_RS09245	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
A6J51_RS09250	COG0789	Transcriptional regulator
A6J51_RS09285	COG1388	LysM domain
A6J51_RS09285	COG0741	lytic transglycosylase activity
A6J51_RS09320	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A6J51_RS09330	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A6J51_RS09335	COG0633	Ferredoxin
A6J51_RS09385	COG2951	lytic endotransglycosylase activity
A6J51_RS09400	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A6J51_RS09405	COG0318	PFAM AMP-dependent synthetase and ligase
A6J51_RS09440	COG2608	mercury ion transmembrane transporter activity
A6J51_RS09450	COG4797	methyltransferase
A6J51_RS09450	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A6J51_RS09465	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A6J51_RS09475	COG0523	cobalamin synthesis protein
A6J51_RS09480	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A6J51_RS09505	COG0251	oxidation-reduction process
A6J51_RS09520	COG0697	spore germination
A6J51_RS09525	COG1027	Aspartate ammonia-lyase
A6J51_RS09535	COG2353	YceI-like domain
A6J51_RS09590	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A6J51_RS09600	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A6J51_RS09605	COG2217	Heavy metal translocating P-type atpase
A6J51_RS09640	COG0583	DNA-binding transcription factor activity
A6J51_RS09655	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A6J51_RS09705	COG2197	response regulator
A6J51_RS09710	COG3850	Histidine kinase
A6J51_RS09720	COG0307	riboflavin synthase, alpha
A6J51_RS09735	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A6J51_RS09755	COG0488	(ABC) transporter
A6J51_RS09760	COG1393	Belongs to the ArsC family
A6J51_RS09795	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A6J51_RS09800	COG2890	protein-(glutamine-N5) methyltransferase activity
A6J51_RS09810	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A6J51_RS09835	COG0488	(ABC) transporter
A6J51_RS10105	COG4453	Protein conserved in bacteria
A6J51_RS10165	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A6J51_RS10210	COG1192	Involved in chromosome partitioning
A6J51_RS10380	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
A6J51_RS10395	COG0330	HflC and HflK could
A6J51_RS10400	COG0628	permease
A6J51_RS10455	COG0557	exoribonuclease II activity
A6J51_RS10480	COG1217	gtp-binding protein TYPA
A6J51_RS10510	COG2895	sulfate adenylyltransferase (ATP) activity
A6J51_RS10550	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A6J51_RS10570	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A6J51_RS10585	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
A6J51_RS10590	COG2975	iron-sulfur cluster assembly
A6J51_RS10600	COG0633	Ferredoxin
A6J51_RS10620	COG1562	ergosterol biosynthetic process
A6J51_RS10630	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
A6J51_RS10760	COG4178	(ABC) transporter
A6J51_RS10765	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A6J51_RS10800	COG2866	Carboxypeptidase
A6J51_RS10810	COG3012	SEC-C Motif Domain Protein
A6J51_RS10810	COG3318	Belongs to the UPF0149 family
A6J51_RS10885	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
A6J51_RS10895	COG2841	Protein conserved in bacteria
A6J51_RS10910	COG0405	Gamma-glutamyltransferase
A6J51_RS10925	COG0586	Pfam SNARE associated Golgi protein
A6J51_RS10930	COG0488	(ABC) transporter
A6J51_RS10950	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
A6J51_RS10960	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
A6J51_RS10990	COG2801	Transposase and inactivated derivatives
A6J51_RS11115	COG0277	FAD linked oxidase domain protein
A6J51_RS11135	COG1773	rubredoxin
A6J51_RS11250	COG0560	Phosphoserine phosphatase
A6J51_RS11255	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
A6J51_RS11265	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
A6J51_RS11270	COG2249	NAD(P)H dehydrogenase (quinone) activity
A6J51_RS11335	COG0512	Glutamine amidotransferase of anthranilate synthase
A6J51_RS11390	COG1943	Transposase
A6J51_RS11415	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A6J51_RS11425	COG0508	dehydrogenase complex catalyzes the overall conversion of
A6J51_RS11430	COG0567	Dehydrogenase, E1 component
A6J51_RS11445	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A6J51_RS11470	COG0678	peroxiredoxin activity
A6J51_RS11470	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A6J51_RS11505	COG2813	Specifically methylates the guanine in position
A6J51_RS11505	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A6J51_RS11560	COG2233	PERMEase
A6J51_RS11625	COG1607	acyl-coa hydrolase
A6J51_RS11630	COG4221	oxidoreductase activity
A6J51_RS11765	COG1196	nuclear chromosome segregation
A6J51_RS11915	COG0582	viral genome integration into host DNA
A6J51_RS11935	COG0436	Aminotransferase
A6J51_RS12005	COG0305	Participates in initiation and elongation during chromosome replication
A6J51_RS12015	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
A6J51_RS12025	COG1755	Isoprenylcysteine carboxyl methyltransferase
A6J51_RS12045	COG4208	sulfate ABC transporter
A6J51_RS12055	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A6J51_RS12065	COG1686	Belongs to the peptidase S11 family
A6J51_RS12265	COG0438	transferase activity, transferring glycosyl groups
A6J51_RS12270	COG1702	phosphate starvation-inducible protein PhoH
A6J51_RS12305	COG0312	modulator of DNA gyrase
A6J51_RS12310	COG1278	Cold shock
A6J51_RS12340	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
A6J51_RS12340	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A6J51_RS12395	COG1309	transcriptional regulator
A6J51_RS12400	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A6J51_RS12415	COG1187	pseudouridine synthase activity
A6J51_RS12420	COG0778	Nitroreductase
A6J51_RS12430	COG0626	cystathionine gamma-synthase activity
A6J51_RS12450	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A6J51_RS12455	COG2867	negative regulation of translational initiation
A6J51_RS12485	COG0471	metal ion transport
A6J51_RS12490	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A6J51_RS12500	COG1126	abc transporter atp-binding protein
A6J51_RS12505	COG0765	amino acid transport
A6J51_RS12510	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6J51_RS12520	COG2837	iron assimilation
A6J51_RS12525	COG1074	ATP-dependent DNA helicase activity
A6J51_RS12585	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
A6J51_RS12595	COG0084	hydrolase, TatD family'
A6J51_RS12615	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A6J51_RS12625	COG0681	Belongs to the peptidase S26 family
A6J51_RS12710	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A6J51_RS12730	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
A6J51_RS12740	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A6J51_RS12760	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
A6J51_RS12760	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A6J51_RS12780	COG0497	DNA recombination
A6J51_RS12820	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A6J51_RS12820	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A6J51_RS12930	COG2354	Protein conserved in bacteria
A6J51_RS12935	COG2354	Protein conserved in bacteria
A6J51_RS12960	COG1561	YicC-like family, N-terminal region