locus-tag	class	description
DV171_RS00090	COG0318	PFAM AMP-dependent synthetase and ligase
DV171_RS00120	COG1349	DNA-binding transcription factor activity
DV171_RS00125	COG2431	L-lysine efflux transmembrane transporter activity
DV171_RS00130	COG1802	Transcriptional regulator
DV171_RS00140	COG1765	OsmC-like protein
DV171_RS00150	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DV171_RS00180	COG1049	propionate catabolic process, 2-methylcitrate cycle
DV171_RS00205	COG0028	Belongs to the TPP enzyme family
DV171_RS00225	COG1999	signal sequence binding
DV171_RS00255	COG2084	Dehydrogenase
DV171_RS00270	COG0616	signal peptide processing
DV171_RS00305	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DV171_RS00315	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DV171_RS00400	COG1275	C4-dicarboxylate transporter malic acid transport protein
DV171_RS00420	COG5002	protein histidine kinase activity
DV171_RS00470	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
DV171_RS00470	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
DV171_RS00475	COG0569	domain protein
DV171_RS00500	COG0351	phosphomethylpyrimidine kinase
DV171_RS00655	COG0494	nUDIX hydrolase
DV171_RS00675	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DV171_RS00700	COG1178	ABC-type Fe3 transport system permease component
DV171_RS00750	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
DV171_RS00780	COG2833	Protein of unknown function (DUF455)
DV171_RS00810	COG3676	manually curated
DV171_RS00845	COG0004	ammonium transporteR
DV171_RS00850	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DV171_RS00860	COG1177	transmembrane transport
DV171_RS00865	COG1176	ABC-type spermidine putrescine transport system, permease component I
DV171_RS00870	COG3842	ATPase activity
DV171_RS00880	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DV171_RS00885	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DV171_RS00890	COG1862	Preprotein translocase
DV171_RS00895	COG0123	including yeast histone deacetylase and acetoin utilization protein
DV171_RS00900	COG1063	alcohol dehydrogenase
DV171_RS00925	COG0805	protein transport
DV171_RS00945	COG0745	RESPONSE REGULATOR receiver
DV171_RS00950	COG2205	protein histidine kinase activity
DV171_RS00985	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DV171_RS00990	COG0803	Belongs to the bacterial solute-binding protein 9 family
DV171_RS01035	COG2274	protein secretion by the type I secretion system
DV171_RS01065	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
DV171_RS01065	COG0644	oxidoreductase
DV171_RS01110	COG1522	sequence-specific DNA binding
DV171_RS01120	COG2832	Protein of unknown function (DUF454)
DV171_RS01170	COG1477	protein flavinylation
DV171_RS01175	COG2991	Protein conserved in bacteria
DV171_RS01185	COG1045	serine acetyltransferase
DV171_RS01255	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DV171_RS01260	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DV171_RS01270	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DV171_RS01290	COG1196	nuclear chromosome segregation
DV171_RS01310	COG1620	l-lactate permease
DV171_RS01325	COG1448	Aminotransferase
DV171_RS01350	COG1757	Na H antiporter
DV171_RS01385	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DV171_RS01390	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DV171_RS01400	COG1757	Na H antiporter
DV171_RS01420	COG3759	membrane
DV171_RS01425	COG0720	synthase
DV171_RS01485	COG3210	domain, Protein
DV171_RS01540	COG3210	domain, Protein
DV171_RS01545	COG2831	hemolysin activation secretion protein
DV171_RS01630	COG1530	ribonuclease E activity
DV171_RS01645	COG2851	Citrate transporter
DV171_RS01650	COG0431	NADPH-dependent FMN reductase
DV171_RS01685	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DV171_RS01690	COG1333	cytochrome c biogenesis protein
DV171_RS01780	COG0121	glutamine amidotransferase
DV171_RS01790	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DV171_RS01790	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DV171_RS01805	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DV171_RS01815	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DV171_RS01825	COG3977	Valine--pyruvate aminotransferase
DV171_RS01830	COG0613	PHP domain protein
DV171_RS01895	COG0546	phosphoglycolate phosphatase activity
DV171_RS01915	COG0196	riboflavin kinase activity
DV171_RS01945	COG0012	GTP binding
DV171_RS01980	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DV171_RS01990	COG0489	protein tyrosine kinase activity
DV171_RS02040	COG2852	Protein conserved in bacteria
DV171_RS02060	COG0583	DNA-binding transcription factor activity
DV171_RS02070	COG2249	NAD(P)H dehydrogenase (quinone) activity
DV171_RS02095	COG0511	ligase activity, forming carbon-carbon bonds
DV171_RS02100	COG0439	Biotin carboxylase
DV171_RS02165	COG1214	PFAM Peptidase M22, glycoprotease
DV171_RS02195	COG1505	serine-type exopeptidase activity
DV171_RS02240	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DV171_RS02245	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DV171_RS02250	COG1956	GAF domain-containing protein
DV171_RS02320	COG0338	D12 class N6 adenine-specific DNA methyltransferase
DV171_RS02465	COG1028	Short-chain dehydrogenase reductase Sdr
DV171_RS02480	COG1943	Transposase
DV171_RS02525	COG0483	inositol monophosphate 1-phosphatase activity
DV171_RS02530	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DV171_RS02570	COG1216	Glycosyl transferase, family 2
DV171_RS02635	COG0356	it plays a direct role in the translocation of protons across the membrane
DV171_RS02675	COG1464	Belongs to the NlpA lipoprotein family
DV171_RS02680	COG2011	ABC-type metal ion transport system permease component
DV171_RS02685	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DV171_RS02700	COG1610	YqeY-like protein
DV171_RS02705	COG2969	positive regulation of protein catabolic process
DV171_RS02710	COG0625	glutathione transferase activity
DV171_RS02735	COG0824	Thioesterase
DV171_RS02755	COG2854	intermembrane phospholipid transfer
DV171_RS02760	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
DV171_RS02765	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DV171_RS02770	COG1127	ABC transporter
DV171_RS02795	COG1012	belongs to the aldehyde dehydrogenase family
DV171_RS02805	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DV171_RS02805	COG0512	Glutamine amidotransferase of anthranilate synthase
DV171_RS02845	COG3676	manually curated
DV171_RS02850	COG0733	neurotransmitter:sodium symporter activity
DV171_RS02875	COG4316	Uncharacterized protein conserved in bacteria (DUF2251)
DV171_RS02955	COG4605	iron ion homeostasis
DV171_RS02965	COG4604	ABC transporter, ATP-binding protein
DV171_RS02970	COG0347	Belongs to the P(II) protein family
DV171_RS03000	COG2239	Acts as a magnesium transporter
DV171_RS03015	COG0791	NLP P60 protein
DV171_RS03030	COG1380	Effector of murein hydrolase LrgA
DV171_RS03035	COG1346	cytolysis
DV171_RS03045	COG0038	chloride channel
DV171_RS03050	COG1643	Atp-dependent helicase
DV171_RS03065	COG1643	Atp-dependent helicase
DV171_RS03105	COG1555	photosystem II stabilization
DV171_RS03105	COG1596	polysaccharide export
DV171_RS03140	COG0564	pseudouridine synthase activity
DV171_RS03165	COG0799	negative regulation of ribosome biogenesis
DV171_RS03175	COG0288	reversible hydration of carbon dioxide
DV171_RS03185	COG2610	gluconate transmembrane transporter activity
DV171_RS03190	COG3265	gluconokinase activity
DV171_RS03205	COG0814	amino acid
DV171_RS03215	COG1368	sulfuric ester hydrolase activity
DV171_RS03365	COG3842	ATPase activity
DV171_RS03390	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DV171_RS03405	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
DV171_RS03410	COG1793	dna ligase
DV171_RS03415	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DV171_RS03425	COG2857	Cytochrome c1
DV171_RS03430	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DV171_RS03435	COG0723	plastoquinol--plastocyanin reductase activity
DV171_RS03445	COG0583	DNA-binding transcription factor activity
DV171_RS03490	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DV171_RS03525	COG0312	modulator of DNA gyrase
DV171_RS03585	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
DV171_RS03640	COG0708	Exodeoxyribonuclease III
DV171_RS03670	COG3038	cytochrome b561
DV171_RS03700	COG0024	Methionine aminopeptidase
DV171_RS03885	COG0616	signal peptide processing
DV171_RS03885	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DV171_RS03890	COG1546	Belongs to the CinA family
DV171_RS03890	COG1058	Belongs to the CinA family
DV171_RS03950	COG3104	oligopeptide transport
DV171_RS03970	COG4667	esterase of the alpha-beta hydrolase superfamily
DV171_RS03975	COG2259	Doxx family
DV171_RS03990	COG3219	Protein conserved in bacteria
DV171_RS03995	COG1595	DNA-templated transcription, initiation
DV171_RS04045	COG1739	Uncharacterized protein family UPF0029
DV171_RS04060	COG0859	PFAM glycosyl transferase family 9
DV171_RS04065	COG1335	isochorismatase
DV171_RS04115	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DV171_RS04125	COG2884	Cell division ATP-binding protein ftsE
DV171_RS04160	COG0861	Integral membrane protein TerC family
DV171_RS04170	COG1519	Transferase
DV171_RS04175	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
DV171_RS04250	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DV171_RS04295	COG2824	Alkylphosphonate utilization operon protein PhnA
DV171_RS04325	COG1546	Belongs to the CinA family
DV171_RS04380	COG1289	transmembrane transporter activity
DV171_RS04405	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DV171_RS04450	COG1596	polysaccharide export
DV171_RS04450	COG1555	photosystem II stabilization
DV171_RS04460	COG1297	OPT oligopeptide transporter protein
DV171_RS04575	COG0786	glutamate:sodium symporter activity
DV171_RS04610	COG0469	pyruvate kinase activity
DV171_RS04660	COG1652	LysM domain
DV171_RS04685	COG5000	phosphorelay sensor kinase activity
DV171_RS04690	COG2204	response regulator
DV171_RS04695	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DV171_RS04695	COG0758	DNA mediated transformation
DV171_RS04720	COG1476	TRANSCRIPTIONal
DV171_RS04725	COG0742	ribosomal rna small subunit methyltransferase
DV171_RS04730	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
DV171_RS04760	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DV171_RS04960	COG0201	protein transport
DV171_RS05045	COG1115	amino acid carrier protein
DV171_RS05130	COG1192	Involved in chromosome partitioning
DV171_RS05150	COG1115	amino acid carrier protein
DV171_RS05160	COG1530	ribonuclease E activity
DV171_RS05170	COG0564	pseudouridine synthase activity
DV171_RS05235	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DV171_RS05280	COG1760	l-serine dehydratase
DV171_RS05330	COG0753	catalase activity
DV171_RS05355	COG0385	Bile acid
DV171_RS05365	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DV171_RS05425	COG1914	H( )-stimulated, divalent metal cation uptake system
DV171_RS05435	COG1984	allophanate hydrolase subunit 2
DV171_RS05440	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
DV171_RS05450	COG0210	DNA helicase
DV171_RS05470	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
DV171_RS05475	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DV171_RS05495	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
DV171_RS05500	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
DV171_RS05510	COG1034	ATP synthesis coupled electron transport
DV171_RS05565	COG0142	geranyltranstransferase activity
DV171_RS05580	COG1132	(ABC) transporter
DV171_RS05610	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
DV171_RS05615	COG1040	competence protein
DV171_RS05640	COG0514	ATP-dependent DNA helicase (RecQ)
DV171_RS05665	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DV171_RS05680	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DV171_RS05695	COG0557	exoribonuclease II activity
DV171_RS05700	COG1611	Belongs to the LOG family
DV171_RS05710	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DV171_RS05720	COG1199	ATP-dependent helicase activity
DV171_RS05770	COG0583	DNA-binding transcription factor activity
DV171_RS05775	COG2259	Doxx family
DV171_RS05790	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DV171_RS05795	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DV171_RS05840	COG1596	polysaccharide export
DV171_RS05840	COG1555	photosystem II stabilization
DV171_RS05875	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
DV171_RS05885	COG2954	triphosphatase activity
DV171_RS05890	COG1981	membrane
DV171_RS05930	COG0739	heme binding
DV171_RS05940	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
DV171_RS06000	COG0142	geranyltranstransferase activity
DV171_RS06070	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DV171_RS06085	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
DV171_RS06110	COG2350	Protein conserved in bacteria
DV171_RS06135	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DV171_RS06160	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
DV171_RS06170	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
DV171_RS06175	COG1137	ATPase activity
DV171_RS06205	COG2814	Major facilitator Superfamily
DV171_RS06345	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DV171_RS06350	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DV171_RS06355	COG0583	DNA-binding transcription factor activity
DV171_RS06380	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
DV171_RS06385	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
DV171_RS06390	COG0488	(ABC) transporter
DV171_RS06400	COG2017	converts alpha-aldose to the beta-anomer
DV171_RS06415	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DV171_RS06455	COG0708	Exodeoxyribonuclease III
DV171_RS06500	COG2960	long-chain fatty acid transporting porin activity
DV171_RS06570	COG2194	sulfuric ester hydrolase activity
DV171_RS06575	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DV171_RS06650	COG2252	PERMEase
DV171_RS06665	COG0372	Belongs to the citrate synthase family
DV171_RS06680	COG2828	Protein conserved in bacteria
DV171_RS06690	COG0009	L-threonylcarbamoyladenylate synthase
DV171_RS06695	COG1959	2 iron, 2 sulfur cluster binding
DV171_RS06710	COG0287	Prephenate dehydrogenase
DV171_RS06715	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DV171_RS06750	COG0697	spore germination
DV171_RS06760	COG2814	Major facilitator Superfamily
DV171_RS06835	COG0802	atpase or kinase
DV171_RS06930	COG0471	metal ion transport
DV171_RS06935	COG1376	ErfK ybiS ycfS ynhG family protein
DV171_RS06940	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DV171_RS06950	COG2830	Protein of unknown function (DUF452)
DV171_RS06955	COG0500	methyltransferase
DV171_RS07040	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DV171_RS07055	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DV171_RS07065	COG2999	glutathione oxidoreductase activity
DV171_RS07090	COG1994	Peptidase M50
DV171_RS07110	COG3453	Protein conserved in bacteria
DV171_RS07110	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DV171_RS07120	COG3278	Belongs to the heme-copper respiratory oxidase family
DV171_RS07135	COG2010	Cytochrome c
DV171_RS07150	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
DV171_RS07155	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
DV171_RS07190	COG1620	l-lactate permease
DV171_RS07200	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DV171_RS07220	COG0733	neurotransmitter:sodium symporter activity
DV171_RS07300	COG0586	Pfam SNARE associated Golgi protein
DV171_RS07305	COG0252	asparaginase activity
DV171_RS07325	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DV171_RS07340	COG0187	DNA topoisomerase II activity
DV171_RS07370	COG3245	cytochrome
DV171_RS07410	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
DV171_RS07410	COG3008	intermembrane lipid transfer
DV171_RS07415	COG2995	paraquat-inducible protein a
DV171_RS07450	COG0826	peptidase U32
DV171_RS07460	COG0561	phosphatase activity
DV171_RS07480	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DV171_RS07485	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DV171_RS07525	COG1596	polysaccharide export
DV171_RS07525	COG1555	photosystem II stabilization
DV171_RS07600	COG1115	amino acid carrier protein
DV171_RS07605	COG1272	protein, Hemolysin III
DV171_RS07615	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
DV171_RS07650	COG2194	sulfuric ester hydrolase activity
DV171_RS07655	COG0778	Nitroreductase
DV171_RS07675	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DV171_RS07695	COG1619	proteins homologs of microcin C7 resistance protein MccF
DV171_RS07745	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DV171_RS07770	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DV171_RS07780	COG0280	phosphate acetyltransferase
DV171_RS07780	COG0281	malic enzyme
DV171_RS07835	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
DV171_RS07920	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
DV171_RS07935	COG0285	dihydrofolate synthase activity
DV171_RS07950	COG1126	abc transporter atp-binding protein
DV171_RS08010	COG0385	Bile acid
DV171_RS08025	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
DV171_RS08030	COG1466	dna polymerase III delta subunit
DV171_RS08045	COG1561	YicC-like family, N-terminal region
DV171_RS08070	COG3263	regulation of cellular component size
DV171_RS08075	COG3263	regulation of cellular component size
DV171_RS08180	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DV171_RS08180	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DV171_RS08215	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
DV171_RS08220	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DV171_RS08225	COG0497	DNA recombination
DV171_RS08245	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
DV171_RS08245	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DV171_RS08265	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DV171_RS08275	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
DV171_RS08295	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DV171_RS08385	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DV171_RS08405	COG0084	hydrolase, TatD family'
DV171_RS08415	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
DV171_RS08480	COG1074	ATP-dependent DNA helicase activity
DV171_RS08485	COG2837	iron assimilation
DV171_RS08495	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DV171_RS08500	COG0765	amino acid transport
DV171_RS08505	COG1126	abc transporter atp-binding protein
DV171_RS08515	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DV171_RS08520	COG0471	metal ion transport
DV171_RS08555	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DV171_RS08575	COG0626	cystathionine gamma-synthase activity
DV171_RS08585	COG0778	Nitroreductase
DV171_RS08590	COG1187	pseudouridine synthase activity
DV171_RS08605	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DV171_RS08610	COG1309	transcriptional regulator
DV171_RS08705	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
DV171_RS08705	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
DV171_RS08775	COG1278	Cold shock
DV171_RS08780	COG0312	modulator of DNA gyrase
DV171_RS08815	COG1702	phosphate starvation-inducible protein PhoH
DV171_RS08970	COG0564	pseudouridine synthase activity
DV171_RS09045	COG1686	Belongs to the peptidase S11 family
DV171_RS09055	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DV171_RS09065	COG4208	sulfate ABC transporter
DV171_RS09080	COG1755	Isoprenylcysteine carboxyl methyltransferase
DV171_RS09095	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DV171_RS09105	COG0305	Participates in initiation and elongation during chromosome replication
DV171_RS09155	COG0436	Aminotransferase
DV171_RS09325	COG1196	nuclear chromosome segregation
DV171_RS09460	COG4221	oxidoreductase activity
DV171_RS09465	COG1607	acyl-coa hydrolase
DV171_RS09500	COG2233	PERMEase
DV171_RS09515	COG0590	tRNA wobble adenosine to inosine editing
DV171_RS09545	COG2813	Specifically methylates the guanine in position
DV171_RS09545	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DV171_RS09585	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
DV171_RS09585	COG0678	peroxiredoxin activity
DV171_RS09610	COG1053	succinate dehydrogenase
DV171_RS09615	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DV171_RS09635	COG0567	Dehydrogenase, E1 component
DV171_RS09640	COG0508	dehydrogenase complex catalyzes the overall conversion of
DV171_RS09650	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DV171_RS09675	COG1943	Transposase
DV171_RS09795	COG2249	NAD(P)H dehydrogenase (quinone) activity
DV171_RS09800	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
DV171_RS09810	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
DV171_RS09820	COG0560	Phosphoserine phosphatase
DV171_RS09960	COG0277	FAD linked oxidase domain protein
DV171_RS10055	COG2801	Transposase and inactivated derivatives
DV171_RS10090	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
DV171_RS10100	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
DV171_RS10120	COG0488	(ABC) transporter
DV171_RS10125	COG0586	Pfam SNARE associated Golgi protein
DV171_RS10165	COG0405	Gamma-glutamyltransferase
DV171_RS10180	COG2841	Protein conserved in bacteria
DV171_RS10190	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
DV171_RS10205	COG0494	nUDIX hydrolase
DV171_RS10260	COG3012	SEC-C Motif Domain Protein
DV171_RS10260	COG3318	Belongs to the UPF0149 family
DV171_RS10270	COG2866	Carboxypeptidase
DV171_RS10300	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DV171_RS10305	COG4178	(ABC) transporter
DV171_RS10315	COG4178	(ABC) transporter
DV171_RS10505	COG2369	cell adhesion
DV171_RS10510	COG5005	Phage virion morphogenesis
DV171_RS10515	COG4388	Caudovirus prohead serine protease
DV171_RS10520	COG4397	Mu-like prophage major head subunit gpT
DV171_RS10665	COG0300	oxidoreductase activity
DV171_RS10670	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
DV171_RS10695	COG0633	Ferredoxin
DV171_RS10710	COG2975	iron-sulfur cluster assembly
DV171_RS10715	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
DV171_RS10730	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DV171_RS10750	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DV171_RS10800	COG2895	sulfate adenylyltransferase (ATP) activity
DV171_RS10835	COG1217	gtp-binding protein TYPA
DV171_RS10860	COG0557	exoribonuclease II activity
DV171_RS10915	COG0628	permease
DV171_RS10985	COG0488	(ABC) transporter
DV171_RS11010	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DV171_RS11025	COG2890	protein-(glutamine-N5) methyltransferase activity
DV171_RS11030	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DV171_RS11060	COG1393	Belongs to the ArsC family
DV171_RS11065	COG0488	(ABC) transporter
DV171_RS11085	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DV171_RS11110	COG2197	response regulator
DV171_RS11165	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DV171_RS11180	COG0583	DNA-binding transcription factor activity
DV171_RS11215	COG2217	Heavy metal translocating P-type atpase
DV171_RS11220	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DV171_RS11230	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DV171_RS11275	COG2353	YceI-like domain
DV171_RS11285	COG1027	Aspartate ammonia-lyase
DV171_RS11290	COG0697	spore germination
DV171_RS11300	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DV171_RS11305	COG0251	oxidation-reduction process
DV171_RS11325	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DV171_RS11330	COG0523	cobalamin synthesis protein
DV171_RS11340	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DV171_RS11355	COG4797	methyltransferase
DV171_RS11355	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DV171_RS11365	COG2608	mercury ion transmembrane transporter activity
DV171_RS11400	COG0318	PFAM AMP-dependent synthetase and ligase
DV171_RS11405	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DV171_RS11415	COG3676	manually curated
DV171_RS11420	COG2951	lytic endotransglycosylase activity
DV171_RS11440	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DV171_RS11470	COG0633	Ferredoxin
DV171_RS11475	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DV171_RS11485	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DV171_RS11520	COG0741	lytic transglycosylase activity
DV171_RS11520	COG1388	LysM domain
DV171_RS11555	COG0789	Transcriptional regulator
DV171_RS11560	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
DV171_RS11565	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
DV171_RS11570	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
DV171_RS11625	COG1183	phosphatidylcholine synthase activity
DV171_RS11630	COG0730	response to heat
DV171_RS11665	COG0492	ferredoxin-NADP+ reductase activity
DV171_RS11670	COG2217	Heavy metal translocating P-type atpase
DV171_RS11695	COG1943	Transposase
DV171_RS11720	COG0793	Belongs to the peptidase S41A family
DV171_RS11735	COG3045	CreA protein
DV171_RS11750	COG0179	Fumarylacetoacetate (FAA) hydrolase
DV171_RS11765	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
DV171_RS11770	COG0508	dehydrogenase complex catalyzes the overall conversion of
DV171_RS11775	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DV171_RS11805	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
DV171_RS11815	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DV171_RS11815	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DV171_RS11840	COG1012	belongs to the aldehyde dehydrogenase family
DV171_RS11845	COG2095	MarC family integral membrane protein
DV171_RS11860	COG2990	Protein conserved in bacteria
DV171_RS11870	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DV171_RS11870	COG0543	2 iron, 2 sulfur cluster binding
DV171_RS11910	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DV171_RS11940	COG0513	Belongs to the DEAD box helicase family
DV171_RS11990	COG2189	Belongs to the N(4) N(6)-methyltransferase family
DV171_RS11995	COG3421	Type III restriction
DV171_RS12000	COG1304	FMN binding
DV171_RS12020	COG0822	iron-sulfur transferase activity
DV171_RS12030	COG3036	rescue of stalled ribosome
DV171_RS12045	COG3676	manually curated
DV171_RS12070	COG1737	Transcriptional regulator
DV171_RS12085	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
DV171_RS12095	COG0800	Aldolase
DV171_RS12105	COG1194	a g-specific adenine glycosylase
DV171_RS12160	COG0308	aminopeptidase N
DV171_RS12170	COG1560	Kdo2-lipid A biosynthetic process
DV171_RS12185	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DV171_RS12195	COG0513	Belongs to the DEAD box helicase family
DV171_RS12285	COG0791	NLP P60 protein
DV171_RS12295	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DV171_RS12300	COG0477	Major facilitator Superfamily
DV171_RS12305	COG0247	lactate metabolic process
DV171_RS12315	COG1139	Iron-sulfur cluster binding protein
DV171_RS12320	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
DV171_RS12345	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DV171_RS12375	COG0210	DNA helicase
DV171_RS12430	COG2070	2-Nitropropane dioxygenase
DV171_RS12440	COG0348	domain, Protein
DV171_RS12465	COG0697	spore germination
DV171_RS12480	COG2814	Major facilitator Superfamily
DV171_RS12485	COG0739	heme binding
DV171_RS12485	COG1196	nuclear chromosome segregation
DV171_RS12485	COG0741	lytic transglycosylase activity
DV171_RS12505	COG1943	Transposase
DV171_RS12585	COG0436	Aminotransferase
DV171_RS12590	COG1942	4-Oxalocrotonate Tautomerase
DV171_RS12630	COG1607	acyl-coa hydrolase
DV171_RS12645	COG1253	flavin adenine dinucleotide binding
DV171_RS12695	COG1966	Carbon starvation protein
DV171_RS12770	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
DV171_RS12820	COG0765	amino acid transport
DV171_RS12890	COG1562	ergosterol biosynthetic process
DV171_RS12905	COG0277	FAD linked oxidase domain protein
DV171_RS12930	COG0859	PFAM glycosyl transferase family 9
DV171_RS12940	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DV171_RS12965	COG3945	hemerythrin HHE cation binding domain