locus-tag	class	description
LA24_RS00050	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LA24_RS00055	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LA24_RS00075	COG2259	Doxx family
LA24_RS00080	COG0583	DNA-binding transcription factor activity
LA24_RS00105	COG1385	rRNA (uridine-N3-)-methyltransferase activity
LA24_RS00125	COG1216	Glycosyl transferase, family 2
LA24_RS00180	COG0356	it plays a direct role in the translocation of protons across the membrane
LA24_RS00215	COG1464	Belongs to the NlpA lipoprotein family
LA24_RS00220	COG2011	ABC-type metal ion transport system permease component
LA24_RS00225	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LA24_RS00245	COG1610	YqeY-like protein
LA24_RS00255	COG2969	positive regulation of protein catabolic process
LA24_RS00260	COG0625	glutathione transferase activity
LA24_RS00295	COG0824	Thioesterase
LA24_RS00315	COG2854	intermembrane phospholipid transfer
LA24_RS00320	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
LA24_RS00325	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LA24_RS00330	COG1127	ABC transporter
LA24_RS00345	COG1012	belongs to the aldehyde dehydrogenase family
LA24_RS00355	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LA24_RS00355	COG0512	Glutamine amidotransferase of anthranilate synthase
LA24_RS00385	COG3676	manually curated
LA24_RS00390	COG0733	neurotransmitter:sodium symporter activity
LA24_RS00415	COG4316	Uncharacterized protein conserved in bacteria (DUF2251)
LA24_RS00425	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LA24_RS00425	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LA24_RS00480	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LA24_RS00485	COG4605	iron ion homeostasis
LA24_RS00495	COG4604	ABC transporter, ATP-binding protein
LA24_RS00505	COG0347	Belongs to the P(II) protein family
LA24_RS00530	COG2239	Acts as a magnesium transporter
LA24_RS00540	COG0791	NLP P60 protein
LA24_RS00555	COG1346	cytolysis
LA24_RS00565	COG0038	chloride channel
LA24_RS00570	COG1643	Atp-dependent helicase
LA24_RS00585	COG1643	Atp-dependent helicase
LA24_RS00630	COG1555	photosystem II stabilization
LA24_RS00630	COG1596	polysaccharide export
LA24_RS00670	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
LA24_RS00695	COG1289	transmembrane transporter activity
LA24_RS00765	COG1546	Belongs to the CinA family
LA24_RS00795	COG2824	Alkylphosphonate utilization operon protein PhnA
LA24_RS00840	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LA24_RS00875	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
LA24_RS00880	COG1519	Transferase
LA24_RS00890	COG0861	Integral membrane protein TerC family
LA24_RS00920	COG2884	Cell division ATP-binding protein ftsE
LA24_RS00925	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LA24_RS00975	COG1335	isochorismatase
LA24_RS00980	COG0859	PFAM glycosyl transferase family 9
LA24_RS00995	COG1739	Uncharacterized protein family UPF0029
LA24_RS01015	COG3676	manually curated
LA24_RS01040	COG1595	DNA-templated transcription, initiation
LA24_RS01045	COG3219	Protein conserved in bacteria
LA24_RS01060	COG2259	Doxx family
LA24_RS01065	COG4667	esterase of the alpha-beta hydrolase superfamily
LA24_RS01085	COG3104	oligopeptide transport
LA24_RS01100	COG0729	surface antigen
LA24_RS01130	COG1058	Belongs to the CinA family
LA24_RS01130	COG1546	Belongs to the CinA family
LA24_RS01135	COG0616	signal peptide processing
LA24_RS01285	COG0024	Methionine aminopeptidase
LA24_RS01315	COG3038	cytochrome b561
LA24_RS01335	COG0708	Exodeoxyribonuclease III
LA24_RS01380	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
LA24_RS01430	COG0312	modulator of DNA gyrase
LA24_RS01440	COG2056	Na+-H+ antiporter family
LA24_RS01455	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LA24_RS01490	COG0583	DNA-binding transcription factor activity
LA24_RS01500	COG0723	plastoquinol--plastocyanin reductase activity
LA24_RS01505	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
LA24_RS01510	COG2857	Cytochrome c1
LA24_RS01520	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LA24_RS01525	COG1793	dna ligase
LA24_RS01530	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
LA24_RS01545	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LA24_RS01550	COG3842	ATPase activity
LA24_RS01630	COG1368	sulfuric ester hydrolase activity
LA24_RS01640	COG0814	amino acid
LA24_RS01655	COG3265	gluconokinase activity
LA24_RS01660	COG2610	gluconate transmembrane transporter activity
LA24_RS01670	COG0288	reversible hydration of carbon dioxide
LA24_RS01680	COG0799	negative regulation of ribosome biogenesis
LA24_RS01705	COG0564	pseudouridine synthase activity
LA24_RS01735	COG1596	polysaccharide export
LA24_RS01735	COG1555	photosystem II stabilization
LA24_RS01750	COG1297	OPT oligopeptide transporter protein
LA24_RS01775	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LA24_RS01795	COG2089	acid synthase
LA24_RS01880	COG0786	glutamate:sodium symporter activity
LA24_RS01910	COG0469	pyruvate kinase activity
LA24_RS02025	COG1652	LysM domain
LA24_RS02055	COG5000	phosphorelay sensor kinase activity
LA24_RS02060	COG2204	response regulator
LA24_RS02065	COG0758	DNA mediated transformation
LA24_RS02090	COG1476	TRANSCRIPTIONal
LA24_RS02095	COG0742	ribosomal rna small subunit methyltransferase
LA24_RS02100	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
LA24_RS02130	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LA24_RS02305	COG0201	protein transport
LA24_RS02385	COG1115	amino acid carrier protein
LA24_RS02470	COG1192	Involved in chromosome partitioning
LA24_RS02485	COG1115	amino acid carrier protein
LA24_RS02495	COG1530	ribonuclease E activity
LA24_RS02505	COG0564	pseudouridine synthase activity
LA24_RS02550	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LA24_RS02595	COG1760	l-serine dehydratase
LA24_RS02615	COG0339	signal peptide processing
LA24_RS02625	COG1943	Transposase
LA24_RS02640	COG0753	catalase activity
LA24_RS02645	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
LA24_RS02645	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
LA24_RS02660	COG0385	Bile acid
LA24_RS02665	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LA24_RS02720	COG1914	H( )-stimulated, divalent metal cation uptake system
LA24_RS02730	COG1984	allophanate hydrolase subunit 2
LA24_RS02735	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
LA24_RS02745	COG0210	DNA helicase
LA24_RS02770	COG3676	manually curated
LA24_RS02785	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LA24_RS02805	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
LA24_RS02810	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
LA24_RS02875	COG0142	geranyltranstransferase activity
LA24_RS02890	COG1132	(ABC) transporter
LA24_RS02915	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
LA24_RS02920	COG1040	competence protein
LA24_RS02930	COG2226	methyltransferase
LA24_RS02950	COG0514	ATP-dependent DNA helicase (RecQ)
LA24_RS02970	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LA24_RS02985	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LA24_RS02990	COG0557	exoribonuclease II activity
LA24_RS02995	COG1611	Belongs to the LOG family
LA24_RS03005	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
LA24_RS03015	COG1199	ATP-dependent helicase activity
LA24_RS03065	COG1943	Transposase
LA24_RS03075	COG1028	Short-chain dehydrogenase reductase Sdr
LA24_RS03090	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
LA24_RS03205	COG0338	D12 class N6 adenine-specific DNA methyltransferase
LA24_RS03250	COG1956	GAF domain-containing protein
LA24_RS03255	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
LA24_RS03260	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LA24_RS03290	COG1505	serine-type exopeptidase activity
LA24_RS03320	COG1214	PFAM Peptidase M22, glycoprotease
LA24_RS03370	COG0439	Biotin carboxylase
LA24_RS03375	COG0511	ligase activity, forming carbon-carbon bonds
LA24_RS03395	COG2249	NAD(P)H dehydrogenase (quinone) activity
LA24_RS03400	COG0583	DNA-binding transcription factor activity
LA24_RS03425	COG2852	Protein conserved in bacteria
LA24_RS03460	COG0489	protein tyrosine kinase activity
LA24_RS03470	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LA24_RS03505	COG0012	GTP binding
LA24_RS03535	COG0196	riboflavin kinase activity
LA24_RS03590	COG0613	PHP domain protein
LA24_RS03595	COG3977	Valine--pyruvate aminotransferase
LA24_RS03605	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LA24_RS03625	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LA24_RS03655	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LA24_RS03655	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LA24_RS03665	COG0121	glutamine amidotransferase
LA24_RS03725	COG1333	cytochrome c biogenesis protein
LA24_RS03730	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LA24_RS03760	COG0431	NADPH-dependent FMN reductase
LA24_RS03770	COG2851	Citrate transporter
LA24_RS03775	COG0745	RESPONSE REGULATOR receiver
LA24_RS03785	COG1530	ribonuclease E activity
LA24_RS03800	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LA24_RS03855	COG2831	hemolysin activation secretion protein
LA24_RS03980	COG0720	synthase
LA24_RS03985	COG3759	membrane
LA24_RS04005	COG1757	Na H antiporter
LA24_RS04015	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LA24_RS04020	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
LA24_RS04045	COG1757	Na H antiporter
LA24_RS04065	COG1448	Aminotransferase
LA24_RS04080	COG1620	l-lactate permease
LA24_RS04095	COG1196	nuclear chromosome segregation
LA24_RS04100	COG1064	alcohol dehydrogenase
LA24_RS04110	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LA24_RS04120	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LA24_RS04125	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LA24_RS04170	COG1045	serine acetyltransferase
LA24_RS04180	COG2991	Protein conserved in bacteria
LA24_RS04185	COG1477	protein flavinylation
LA24_RS04225	COG2832	Protein of unknown function (DUF454)
LA24_RS04235	COG1522	sequence-specific DNA binding
LA24_RS04275	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
LA24_RS04275	COG0644	oxidoreductase
LA24_RS04285	COG3676	manually curated
LA24_RS04310	COG0803	Belongs to the bacterial solute-binding protein 9 family
LA24_RS04315	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LA24_RS04350	COG2205	protein histidine kinase activity
LA24_RS04355	COG0745	RESPONSE REGULATOR receiver
LA24_RS04375	COG0805	protein transport
LA24_RS04400	COG1063	alcohol dehydrogenase
LA24_RS04405	COG0123	including yeast histone deacetylase and acetoin utilization protein
LA24_RS04410	COG1862	Preprotein translocase
LA24_RS04415	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LA24_RS04420	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LA24_RS04430	COG3842	ATPase activity
LA24_RS04435	COG1176	ABC-type spermidine putrescine transport system, permease component I
LA24_RS04440	COG1177	transmembrane transport
LA24_RS04445	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LA24_RS04450	COG0004	ammonium transporteR
LA24_RS04480	COG2833	Protein of unknown function (DUF455)
LA24_RS04500	COG0463	Glycosyl transferase, family 2
LA24_RS04515	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
LA24_RS04560	COG1178	ABC-type Fe3 transport system permease component
LA24_RS04580	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LA24_RS04600	COG0494	nUDIX hydrolase
LA24_RS04620	COG2732	(Barnase) inhibitor
LA24_RS04745	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LA24_RS04765	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
LA24_RS04775	COG0281	malic enzyme
LA24_RS04775	COG0280	phosphate acetyltransferase
LA24_RS04825	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
LA24_RS04890	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
LA24_RS04905	COG0285	dihydrofolate synthase activity
LA24_RS04920	COG1126	abc transporter atp-binding protein
LA24_RS04970	COG0385	Bile acid
LA24_RS04980	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
LA24_RS04985	COG1466	dna polymerase III delta subunit
LA24_RS05000	COG1561	YicC-like family, N-terminal region
LA24_RS05015	COG2354	Protein conserved in bacteria
LA24_RS05125	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
LA24_RS05125	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LA24_RS05160	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
LA24_RS05165	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
LA24_RS05170	COG0497	DNA recombination
LA24_RS05185	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LA24_RS05185	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
LA24_RS05205	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
LA24_RS05215	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
LA24_RS05230	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LA24_RS05305	COG0681	Belongs to the peptidase S26 family
LA24_RS05315	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
LA24_RS05335	COG0084	hydrolase, TatD family'
LA24_RS05345	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
LA24_RS05405	COG1074	ATP-dependent DNA helicase activity
LA24_RS05410	COG2837	iron assimilation
LA24_RS05415	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LA24_RS05420	COG0765	amino acid transport
LA24_RS05425	COG1126	abc transporter atp-binding protein
LA24_RS05435	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LA24_RS05440	COG0471	metal ion transport
LA24_RS05465	COG2867	negative regulation of translational initiation
LA24_RS05470	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LA24_RS05490	COG0626	cystathionine gamma-synthase activity
LA24_RS05500	COG0778	Nitroreductase
LA24_RS05505	COG1187	pseudouridine synthase activity
LA24_RS05520	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LA24_RS05525	COG1309	transcriptional regulator
LA24_RS05570	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
LA24_RS05570	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
LA24_RS05600	COG1278	Cold shock
LA24_RS05605	COG0312	modulator of DNA gyrase
LA24_RS05635	COG1702	phosphate starvation-inducible protein PhoH
LA24_RS05640	COG0438	transferase activity, transferring glycosyl groups
LA24_RS05820	COG1686	Belongs to the peptidase S11 family
LA24_RS05825	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LA24_RS05835	COG4208	sulfate ABC transporter
LA24_RS05850	COG1755	Isoprenylcysteine carboxyl methyltransferase
LA24_RS05855	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LA24_RS05860	COG0305	Participates in initiation and elongation during chromosome replication
LA24_RS05905	COG0436	Aminotransferase
LA24_RS05925	COG0582	viral genome integration into host DNA
LA24_RS06075	COG1196	nuclear chromosome segregation
LA24_RS06195	COG4221	oxidoreductase activity
LA24_RS06200	COG1607	acyl-coa hydrolase
LA24_RS06235	COG2233	PERMEase
LA24_RS06290	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LA24_RS06290	COG2813	Specifically methylates the guanine in position
LA24_RS06330	COG0678	peroxiredoxin activity
LA24_RS06330	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
LA24_RS06360	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
LA24_RS06375	COG0567	Dehydrogenase, E1 component
LA24_RS06380	COG0508	dehydrogenase complex catalyzes the overall conversion of
LA24_RS06385	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LA24_RS06405	COG1943	Transposase
LA24_RS06440	COG0512	Glutamine amidotransferase of anthranilate synthase
LA24_RS06455	COG3676	manually curated
LA24_RS06495	COG2249	NAD(P)H dehydrogenase (quinone) activity
LA24_RS06500	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
LA24_RS06510	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
LA24_RS06515	COG0560	Phosphoserine phosphatase
LA24_RS06620	COG1773	rubredoxin
LA24_RS06640	COG0277	FAD linked oxidase domain protein
LA24_RS06775	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
LA24_RS06785	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
LA24_RS06805	COG0488	(ABC) transporter
LA24_RS06810	COG0586	Pfam SNARE associated Golgi protein
LA24_RS06825	COG0405	Gamma-glutamyltransferase
LA24_RS06830	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
LA24_RS06835	COG2841	Protein conserved in bacteria
LA24_RS06845	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
LA24_RS06860	COG0494	nUDIX hydrolase
LA24_RS06905	COG3318	Belongs to the UPF0149 family
LA24_RS06905	COG3012	SEC-C Motif Domain Protein
LA24_RS06915	COG2866	Carboxypeptidase
LA24_RS06940	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LA24_RS06945	COG4178	(ABC) transporter
LA24_RS07005	COG3093	addiction module antidote protein HigA
LA24_RS07025	COG3392	D12 class N6 adenine-specific DNA methyltransferase
LA24_RS07030	COG4178	(ABC) transporter
LA24_RS07065	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
LA24_RS07070	COG1562	ergosterol biosynthetic process
LA24_RS07090	COG0633	Ferredoxin
LA24_RS07105	COG2975	iron-sulfur cluster assembly
LA24_RS07110	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
LA24_RS07125	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LA24_RS07145	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LA24_RS07190	COG2895	sulfate adenylyltransferase (ATP) activity
LA24_RS07225	COG1217	gtp-binding protein TYPA
LA24_RS07250	COG0557	exoribonuclease II activity
LA24_RS07310	COG0628	permease
LA24_RS07315	COG0330	HflC and HflK could
LA24_RS07330	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
LA24_RS07375	COG0488	(ABC) transporter
LA24_RS07400	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
LA24_RS07405	COG2890	protein-(glutamine-N5) methyltransferase activity
LA24_RS07440	COG1393	Belongs to the ArsC family
LA24_RS07445	COG0488	(ABC) transporter
LA24_RS07465	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LA24_RS07485	COG0307	riboflavin synthase, alpha
LA24_RS07495	COG3850	Histidine kinase
LA24_RS07500	COG2197	response regulator
LA24_RS07530	COG1216	Glycosyl transferase, family 2
LA24_RS07555	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LA24_RS07570	COG0583	DNA-binding transcription factor activity
LA24_RS07605	COG2217	Heavy metal translocating P-type atpase
LA24_RS07610	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LA24_RS07620	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
LA24_RS07670	COG2353	YceI-like domain
LA24_RS07675	COG1027	Aspartate ammonia-lyase
LA24_RS07680	COG0697	spore germination
LA24_RS07695	COG0251	oxidation-reduction process
LA24_RS07720	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LA24_RS07725	COG0523	cobalamin synthesis protein
LA24_RS07735	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LA24_RS07750	COG4797	methyltransferase
LA24_RS07750	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LA24_RS07755	COG2608	mercury ion transmembrane transporter activity
LA24_RS07785	COG0318	PFAM AMP-dependent synthetase and ligase
LA24_RS07790	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LA24_RS07800	COG2951	lytic endotransglycosylase activity
LA24_RS07810	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LA24_RS07840	COG0633	Ferredoxin
LA24_RS07845	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LA24_RS07855	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LA24_RS07880	COG1388	LysM domain
LA24_RS07880	COG0741	lytic transglycosylase activity
LA24_RS07910	COG0789	Transcriptional regulator
LA24_RS07915	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
LA24_RS07920	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
LA24_RS07925	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
LA24_RS07985	COG1183	phosphatidylcholine synthase activity
LA24_RS07990	COG0730	response to heat
LA24_RS08015	COG0492	ferredoxin-NADP+ reductase activity
LA24_RS08020	COG2217	Heavy metal translocating P-type atpase
LA24_RS08050	COG0793	Belongs to the peptidase S41A family
LA24_RS08065	COG3045	CreA protein
LA24_RS08080	COG0179	Fumarylacetoacetate (FAA) hydrolase
LA24_RS08095	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
LA24_RS08100	COG0508	dehydrogenase complex catalyzes the overall conversion of
LA24_RS08105	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LA24_RS08125	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
LA24_RS08135	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LA24_RS08135	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LA24_RS08145	COG1012	belongs to the aldehyde dehydrogenase family
LA24_RS08150	COG2095	MarC family integral membrane protein
LA24_RS08165	COG2990	Protein conserved in bacteria
LA24_RS08175	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LA24_RS08175	COG0543	2 iron, 2 sulfur cluster binding
LA24_RS08200	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
LA24_RS08225	COG0513	Belongs to the DEAD box helicase family
LA24_RS08270	COG2189	Belongs to the N(4) N(6)-methyltransferase family
LA24_RS08275	COG2189	Belongs to the N(4) N(6)-methyltransferase family
LA24_RS08280	COG3421	Type III restriction
LA24_RS08285	COG1304	FMN binding
LA24_RS08310	COG0822	iron-sulfur transferase activity
LA24_RS08320	COG3036	rescue of stalled ribosome
LA24_RS08365	COG1737	Transcriptional regulator
LA24_RS08380	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
LA24_RS08390	COG0800	Aldolase
LA24_RS08400	COG1194	a g-specific adenine glycosylase
LA24_RS08425	COG3676	manually curated
LA24_RS08450	COG0308	aminopeptidase N
LA24_RS08465	COG1560	Kdo2-lipid A biosynthetic process
LA24_RS08480	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LA24_RS08490	COG0513	Belongs to the DEAD box helicase family
LA24_RS08560	COG0791	NLP P60 protein
LA24_RS08565	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LA24_RS08570	COG0477	Major facilitator Superfamily
LA24_RS08575	COG0247	lactate metabolic process
LA24_RS08585	COG1139	Iron-sulfur cluster binding protein
LA24_RS08590	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
LA24_RS08615	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
LA24_RS08660	COG0210	DNA helicase
LA24_RS08705	COG2070	2-Nitropropane dioxygenase
LA24_RS08715	COG0348	domain, Protein
LA24_RS08730	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
LA24_RS08740	COG0697	spore germination
LA24_RS08750	COG2814	Major facilitator Superfamily
LA24_RS08755	COG0739	heme binding
LA24_RS08755	COG0741	lytic transglycosylase activity
LA24_RS08755	COG1196	nuclear chromosome segregation
LA24_RS08775	COG1943	Transposase
LA24_RS08825	COG0436	Aminotransferase
LA24_RS08830	COG1942	4-Oxalocrotonate Tautomerase
LA24_RS08870	COG1607	acyl-coa hydrolase
LA24_RS08885	COG1253	flavin adenine dinucleotide binding
LA24_RS08915	COG1966	Carbon starvation protein
LA24_RS08960	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
LA24_RS08995	COG0765	amino acid transport
LA24_RS09060	COG1562	ergosterol biosynthetic process
LA24_RS09080	COG0277	FAD linked oxidase domain protein
LA24_RS09095	COG0859	PFAM glycosyl transferase family 9
LA24_RS09105	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LA24_RS09110	COG1881	PFAM PEBP family protein
LA24_RS09125	COG3945	hemerythrin HHE cation binding domain
LA24_RS09200	COG0318	PFAM AMP-dependent synthetase and ligase
LA24_RS09230	COG1349	DNA-binding transcription factor activity
LA24_RS09235	COG2431	L-lysine efflux transmembrane transporter activity
LA24_RS09240	COG1802	Transcriptional regulator
LA24_RS09245	COG1765	OsmC-like protein
LA24_RS09255	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
LA24_RS09285	COG1049	propionate catabolic process, 2-methylcitrate cycle
LA24_RS09310	COG0028	Belongs to the TPP enzyme family
LA24_RS09320	COG1999	signal sequence binding
LA24_RS09350	COG2084	Dehydrogenase
LA24_RS09375	COG0616	signal peptide processing
LA24_RS09410	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LA24_RS09420	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LA24_RS09470	COG3547	Transposase (IS116 IS110 IS902 family)
LA24_RS09480	COG1275	C4-dicarboxylate transporter malic acid transport protein
LA24_RS09495	COG5002	protein histidine kinase activity
LA24_RS09550	COG0569	domain protein
LA24_RS09570	COG0351	phosphomethylpyrimidine kinase
LA24_RS09610	COG1619	proteins homologs of microcin C7 resistance protein MccF
LA24_RS09630	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LA24_RS09645	COG0778	Nitroreductase
LA24_RS09650	COG2194	sulfuric ester hydrolase activity
LA24_RS09680	COG1160	GTP binding
LA24_RS09690	COG1272	protein, Hemolysin III
LA24_RS09695	COG1115	amino acid carrier protein
LA24_RS09755	COG1596	polysaccharide export
LA24_RS09755	COG1555	photosystem II stabilization
LA24_RS09790	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LA24_RS09795	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LA24_RS09815	COG0561	phosphatase activity
LA24_RS09825	COG0826	peptidase U32
LA24_RS09860	COG2995	paraquat-inducible protein a
LA24_RS09865	COG3008	intermembrane lipid transfer
LA24_RS09865	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
LA24_RS09905	COG3245	cytochrome
LA24_RS09950	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LA24_RS09965	COG0252	asparaginase activity
LA24_RS09970	COG0586	Pfam SNARE associated Golgi protein
LA24_RS10015	COG3676	manually curated
LA24_RS10045	COG0733	neurotransmitter:sodium symporter activity
LA24_RS10065	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
LA24_RS10085	COG1620	l-lactate permease
LA24_RS10120	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
LA24_RS10125	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
LA24_RS10135	COG2010	Cytochrome c
LA24_RS10150	COG3278	Belongs to the heme-copper respiratory oxidase family
LA24_RS10160	COG3453	Protein conserved in bacteria
LA24_RS10160	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LA24_RS10180	COG1994	Peptidase M50
LA24_RS10195	COG2999	glutathione oxidoreductase activity
LA24_RS10200	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LA24_RS10210	COG1538	Outer membrane efflux protein
LA24_RS10215	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LA24_RS10300	COG0500	methyltransferase
LA24_RS10305	COG2830	Protein of unknown function (DUF452)
LA24_RS10315	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LA24_RS10320	COG1376	ErfK ybiS ycfS ynhG family protein
LA24_RS10325	COG0471	metal ion transport
LA24_RS10390	COG0802	atpase or kinase
LA24_RS10450	COG2814	Major facilitator Superfamily
LA24_RS10455	COG0697	spore germination
LA24_RS10515	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LA24_RS10520	COG0287	Prephenate dehydrogenase
LA24_RS10535	COG1959	2 iron, 2 sulfur cluster binding
LA24_RS10540	COG0009	L-threonylcarbamoyladenylate synthase
LA24_RS10550	COG2828	Protein conserved in bacteria
LA24_RS10560	COG5505	Protein of unknown function (DUF819)
LA24_RS10570	COG0372	Belongs to the citrate synthase family
LA24_RS10585	COG2252	PERMEase
LA24_RS10645	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LA24_RS10650	COG2194	sulfuric ester hydrolase activity
LA24_RS10720	COG2960	long-chain fatty acid transporting porin activity
LA24_RS10750	COG0708	Exodeoxyribonuclease III
LA24_RS10795	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LA24_RS10805	COG2017	converts alpha-aldose to the beta-anomer
LA24_RS10815	COG0488	(ABC) transporter
LA24_RS10820	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
LA24_RS10825	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
LA24_RS10845	COG0583	DNA-binding transcription factor activity
LA24_RS10850	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LA24_RS10855	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LA24_RS10945	COG2814	Major facilitator Superfamily
LA24_RS10975	COG1137	ATPase activity
LA24_RS10980	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
LA24_RS10990	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
LA24_RS11015	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LA24_RS11040	COG2350	Protein conserved in bacteria
LA24_RS11065	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
LA24_RS11080	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LA24_RS11140	COG0142	geranyltranstransferase activity
LA24_RS11190	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
LA24_RS11195	COG0739	heme binding
LA24_RS11225	COG1981	membrane
LA24_RS11230	COG2954	triphosphatase activity
LA24_RS11240	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LA24_RS11260	COG3676	manually curated
LA24_RS11275	COG1555	photosystem II stabilization
LA24_RS11275	COG1596	polysaccharide export