locus-tag	class	description
LA50_RS00110	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
LA50_RS00125	COG0330	HflC and HflK could
LA50_RS00130	COG0628	permease
LA50_RS00190	COG0557	exoribonuclease II activity
LA50_RS00215	COG1217	gtp-binding protein TYPA
LA50_RS00250	COG2895	sulfate adenylyltransferase (ATP) activity
LA50_RS00290	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LA50_RS00310	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LA50_RS00325	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
LA50_RS00330	COG2975	iron-sulfur cluster assembly
LA50_RS00345	COG0633	Ferredoxin
LA50_RS00365	COG1562	ergosterol biosynthetic process
LA50_RS00370	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
LA50_RS00405	COG4178	(ABC) transporter
LA50_RS00410	COG3392	D12 class N6 adenine-specific DNA methyltransferase
LA50_RS00430	COG3093	addiction module antidote protein HigA
LA50_RS00490	COG4178	(ABC) transporter
LA50_RS00495	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LA50_RS00520	COG2866	Carboxypeptidase
LA50_RS00530	COG3012	SEC-C Motif Domain Protein
LA50_RS00530	COG3318	Belongs to the UPF0149 family
LA50_RS00575	COG0494	nUDIX hydrolase
LA50_RS00590	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
LA50_RS00600	COG2841	Protein conserved in bacteria
LA50_RS00605	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
LA50_RS00610	COG0405	Gamma-glutamyltransferase
LA50_RS00625	COG0586	Pfam SNARE associated Golgi protein
LA50_RS00630	COG0488	(ABC) transporter
LA50_RS00650	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
LA50_RS00660	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
LA50_RS00795	COG0277	FAD linked oxidase domain protein
LA50_RS00820	COG1773	rubredoxin
LA50_RS00925	COG0560	Phosphoserine phosphatase
LA50_RS00930	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
LA50_RS00940	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
LA50_RS00945	COG2249	NAD(P)H dehydrogenase (quinone) activity
LA50_RS00985	COG3676	manually curated
LA50_RS01000	COG0512	Glutamine amidotransferase of anthranilate synthase
LA50_RS01035	COG1943	Transposase
LA50_RS01055	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LA50_RS01060	COG0508	dehydrogenase complex catalyzes the overall conversion of
LA50_RS01065	COG0567	Dehydrogenase, E1 component
LA50_RS01080	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
LA50_RS01110	COG0678	peroxiredoxin activity
LA50_RS01110	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
LA50_RS01150	COG2813	Specifically methylates the guanine in position
LA50_RS01150	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LA50_RS01205	COG2233	PERMEase
LA50_RS01240	COG1607	acyl-coa hydrolase
LA50_RS01245	COG4221	oxidoreductase activity
LA50_RS01365	COG1196	nuclear chromosome segregation
LA50_RS01515	COG0582	viral genome integration into host DNA
LA50_RS01535	COG0436	Aminotransferase
LA50_RS01580	COG0305	Participates in initiation and elongation during chromosome replication
LA50_RS01585	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LA50_RS01590	COG1755	Isoprenylcysteine carboxyl methyltransferase
LA50_RS01605	COG4208	sulfate ABC transporter
LA50_RS01615	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LA50_RS01620	COG1686	Belongs to the peptidase S11 family
LA50_RS01800	COG0438	transferase activity, transferring glycosyl groups
LA50_RS01805	COG1702	phosphate starvation-inducible protein PhoH
LA50_RS01835	COG0312	modulator of DNA gyrase
LA50_RS01840	COG1278	Cold shock
LA50_RS01870	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
LA50_RS01870	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
LA50_RS01915	COG1309	transcriptional regulator
LA50_RS01920	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LA50_RS01935	COG1187	pseudouridine synthase activity
LA50_RS01940	COG0778	Nitroreductase
LA50_RS01950	COG0626	cystathionine gamma-synthase activity
LA50_RS01970	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LA50_RS01975	COG2867	negative regulation of translational initiation
LA50_RS02000	COG0471	metal ion transport
LA50_RS02005	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LA50_RS02015	COG1126	abc transporter atp-binding protein
LA50_RS02020	COG0765	amino acid transport
LA50_RS02025	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LA50_RS02030	COG2837	iron assimilation
LA50_RS02035	COG1074	ATP-dependent DNA helicase activity
LA50_RS02095	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
LA50_RS02105	COG0084	hydrolase, TatD family'
LA50_RS02125	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
LA50_RS02135	COG0681	Belongs to the peptidase S26 family
LA50_RS02210	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LA50_RS02225	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
LA50_RS02235	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
LA50_RS02255	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
LA50_RS02255	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LA50_RS02270	COG0497	DNA recombination
LA50_RS02275	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
LA50_RS02280	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
LA50_RS02315	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
LA50_RS02315	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LA50_RS02425	COG2354	Protein conserved in bacteria
LA50_RS02440	COG1561	YicC-like family, N-terminal region
LA50_RS02455	COG1466	dna polymerase III delta subunit
LA50_RS02460	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
LA50_RS02470	COG0385	Bile acid
LA50_RS02520	COG1126	abc transporter atp-binding protein
LA50_RS02535	COG0285	dihydrofolate synthase activity
LA50_RS02550	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
LA50_RS02615	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
LA50_RS02665	COG0281	malic enzyme
LA50_RS02665	COG0280	phosphate acetyltransferase
LA50_RS02675	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
LA50_RS02695	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LA50_RS02820	COG2732	(Barnase) inhibitor
LA50_RS02840	COG0494	nUDIX hydrolase
LA50_RS02860	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LA50_RS02880	COG1178	ABC-type Fe3 transport system permease component
LA50_RS02925	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
LA50_RS02930	COG1216	Glycosyl transferase, family 2
LA50_RS02950	COG2833	Protein of unknown function (DUF455)
LA50_RS02980	COG0004	ammonium transporteR
LA50_RS02985	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LA50_RS02990	COG1177	transmembrane transport
LA50_RS02995	COG1176	ABC-type spermidine putrescine transport system, permease component I
LA50_RS03000	COG3842	ATPase activity
LA50_RS03010	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LA50_RS03015	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LA50_RS03020	COG1862	Preprotein translocase
LA50_RS03025	COG0123	including yeast histone deacetylase and acetoin utilization protein
LA50_RS03030	COG1063	alcohol dehydrogenase
LA50_RS03055	COG0805	protein transport
LA50_RS03075	COG0745	RESPONSE REGULATOR receiver
LA50_RS03080	COG2205	protein histidine kinase activity
LA50_RS03115	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LA50_RS03120	COG0803	Belongs to the bacterial solute-binding protein 9 family
LA50_RS03145	COG3676	manually curated
LA50_RS03155	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
LA50_RS03155	COG0644	oxidoreductase
LA50_RS03195	COG1522	sequence-specific DNA binding
LA50_RS03205	COG2832	Protein of unknown function (DUF454)
LA50_RS03245	COG1477	protein flavinylation
LA50_RS03250	COG2991	Protein conserved in bacteria
LA50_RS03260	COG1045	serine acetyltransferase
LA50_RS03305	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LA50_RS03310	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LA50_RS03320	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LA50_RS03330	COG1064	alcohol dehydrogenase
LA50_RS03335	COG1196	nuclear chromosome segregation
LA50_RS03350	COG1620	l-lactate permease
LA50_RS03365	COG1448	Aminotransferase
LA50_RS03385	COG1757	Na H antiporter
LA50_RS03410	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
LA50_RS03415	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LA50_RS03425	COG1757	Na H antiporter
LA50_RS03445	COG3759	membrane
LA50_RS03450	COG0720	synthase
LA50_RS03580	COG2831	hemolysin activation secretion protein
LA50_RS03635	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LA50_RS03650	COG1530	ribonuclease E activity
LA50_RS03660	COG0745	RESPONSE REGULATOR receiver
LA50_RS03665	COG2851	Citrate transporter
LA50_RS03675	COG0431	NADPH-dependent FMN reductase
LA50_RS03710	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LA50_RS03715	COG1333	cytochrome c biogenesis protein
LA50_RS03775	COG0121	glutamine amidotransferase
LA50_RS03785	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LA50_RS03785	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LA50_RS03805	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LA50_RS03810	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LA50_RS03820	COG3977	Valine--pyruvate aminotransferase
LA50_RS03825	COG0613	PHP domain protein
LA50_RS03880	COG0196	riboflavin kinase activity
LA50_RS03910	COG0012	GTP binding
LA50_RS03945	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LA50_RS03955	COG0489	protein tyrosine kinase activity
LA50_RS04040	COG2852	Protein conserved in bacteria
LA50_RS04065	COG0583	DNA-binding transcription factor activity
LA50_RS04070	COG2249	NAD(P)H dehydrogenase (quinone) activity
LA50_RS04090	COG0511	ligase activity, forming carbon-carbon bonds
LA50_RS04095	COG0439	Biotin carboxylase
LA50_RS04145	COG1214	PFAM Peptidase M22, glycoprotease
LA50_RS04175	COG1505	serine-type exopeptidase activity
LA50_RS04205	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LA50_RS04210	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
LA50_RS04215	COG1956	GAF domain-containing protein
LA50_RS04260	COG0338	D12 class N6 adenine-specific DNA methyltransferase
LA50_RS04375	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
LA50_RS04390	COG1028	Short-chain dehydrogenase reductase Sdr
LA50_RS04400	COG1943	Transposase
LA50_RS04500	COG1199	ATP-dependent helicase activity
LA50_RS04510	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
LA50_RS04520	COG1611	Belongs to the LOG family
LA50_RS04525	COG0557	exoribonuclease II activity
LA50_RS04530	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LA50_RS04545	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LA50_RS04565	COG0514	ATP-dependent DNA helicase (RecQ)
LA50_RS04585	COG2226	methyltransferase
LA50_RS04595	COG1040	competence protein
LA50_RS04600	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
LA50_RS04625	COG1132	(ABC) transporter
LA50_RS04640	COG0142	geranyltranstransferase activity
LA50_RS04705	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
LA50_RS04710	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
LA50_RS04730	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LA50_RS04745	COG3676	manually curated
LA50_RS04770	COG0210	DNA helicase
LA50_RS04780	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
LA50_RS04785	COG1984	allophanate hydrolase subunit 2
LA50_RS04795	COG1914	H( )-stimulated, divalent metal cation uptake system
LA50_RS04850	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LA50_RS04855	COG0385	Bile acid
LA50_RS04870	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
LA50_RS04870	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
LA50_RS04875	COG0753	catalase activity
LA50_RS04890	COG1943	Transposase
LA50_RS04900	COG0339	signal peptide processing
LA50_RS04920	COG1760	l-serine dehydratase
LA50_RS04965	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LA50_RS05010	COG0564	pseudouridine synthase activity
LA50_RS05020	COG1530	ribonuclease E activity
LA50_RS05030	COG1115	amino acid carrier protein
LA50_RS05045	COG1192	Involved in chromosome partitioning
LA50_RS05125	COG1115	amino acid carrier protein
LA50_RS05205	COG0201	protein transport
LA50_RS05380	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LA50_RS05410	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
LA50_RS05415	COG0742	ribosomal rna small subunit methyltransferase
LA50_RS05420	COG1476	TRANSCRIPTIONal
LA50_RS05445	COG0758	DNA mediated transformation
LA50_RS05450	COG2204	response regulator
LA50_RS05455	COG5000	phosphorelay sensor kinase activity
LA50_RS05485	COG1652	LysM domain
LA50_RS05600	COG0469	pyruvate kinase activity
LA50_RS05630	COG0786	glutamate:sodium symporter activity
LA50_RS05715	COG2089	acid synthase
LA50_RS05740	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LA50_RS05765	COG1297	OPT oligopeptide transporter protein
LA50_RS05780	COG1555	photosystem II stabilization
LA50_RS05780	COG1596	polysaccharide export
LA50_RS05820	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
LA50_RS05875	COG1546	Belongs to the CinA family
LA50_RS05905	COG2824	Alkylphosphonate utilization operon protein PhnA
LA50_RS05950	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LA50_RS05980	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
LA50_RS05985	COG1519	Transferase
LA50_RS05995	COG0861	Integral membrane protein TerC family
LA50_RS06025	COG2884	Cell division ATP-binding protein ftsE
LA50_RS06030	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LA50_RS06080	COG1335	isochorismatase
LA50_RS06085	COG0859	PFAM glycosyl transferase family 9
LA50_RS06100	COG1739	Uncharacterized protein family UPF0029
LA50_RS06120	COG3676	manually curated
LA50_RS06145	COG1595	DNA-templated transcription, initiation
LA50_RS06150	COG3219	Protein conserved in bacteria
LA50_RS06165	COG2259	Doxx family
LA50_RS06170	COG4667	esterase of the alpha-beta hydrolase superfamily
LA50_RS06190	COG3104	oligopeptide transport
LA50_RS06200	COG0729	surface antigen
LA50_RS06230	COG1058	Belongs to the CinA family
LA50_RS06230	COG1546	Belongs to the CinA family
LA50_RS06235	COG0616	signal peptide processing
LA50_RS06385	COG0024	Methionine aminopeptidase
LA50_RS06415	COG3038	cytochrome b561
LA50_RS06435	COG0708	Exodeoxyribonuclease III
LA50_RS06480	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
LA50_RS06530	COG0312	modulator of DNA gyrase
LA50_RS06540	COG2056	Na+-H+ antiporter family
LA50_RS06555	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LA50_RS06590	COG0583	DNA-binding transcription factor activity
LA50_RS06600	COG0723	plastoquinol--plastocyanin reductase activity
LA50_RS06605	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
LA50_RS06610	COG2857	Cytochrome c1
LA50_RS06620	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LA50_RS06625	COG1793	dna ligase
LA50_RS06630	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
LA50_RS06645	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LA50_RS06650	COG3842	ATPase activity
LA50_RS06725	COG1368	sulfuric ester hydrolase activity
LA50_RS06735	COG0814	amino acid
LA50_RS06750	COG3265	gluconokinase activity
LA50_RS06755	COG2610	gluconate transmembrane transporter activity
LA50_RS06765	COG0288	reversible hydration of carbon dioxide
LA50_RS06775	COG0799	negative regulation of ribosome biogenesis
LA50_RS06800	COG0564	pseudouridine synthase activity
LA50_RS06835	COG1596	polysaccharide export
LA50_RS06835	COG1555	photosystem II stabilization
LA50_RS06880	COG1643	Atp-dependent helicase
LA50_RS06895	COG1643	Atp-dependent helicase
LA50_RS06900	COG0038	chloride channel
LA50_RS06910	COG1346	cytolysis
LA50_RS06925	COG0791	NLP P60 protein
LA50_RS06935	COG2239	Acts as a magnesium transporter
LA50_RS06965	COG0347	Belongs to the P(II) protein family
LA50_RS06975	COG4604	ABC transporter, ATP-binding protein
LA50_RS06985	COG4605	iron ion homeostasis
LA50_RS06990	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LA50_RS07040	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LA50_RS07040	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LA50_RS07050	COG4316	Uncharacterized protein conserved in bacteria (DUF2251)
LA50_RS07075	COG0733	neurotransmitter:sodium symporter activity
LA50_RS07080	COG3676	manually curated
LA50_RS07115	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LA50_RS07115	COG0512	Glutamine amidotransferase of anthranilate synthase
LA50_RS07125	COG1012	belongs to the aldehyde dehydrogenase family
LA50_RS07140	COG1127	ABC transporter
LA50_RS07145	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LA50_RS07150	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
LA50_RS07155	COG2854	intermembrane phospholipid transfer
LA50_RS07175	COG0824	Thioesterase
LA50_RS07210	COG0625	glutathione transferase activity
LA50_RS07215	COG2969	positive regulation of protein catabolic process
LA50_RS07225	COG1610	YqeY-like protein
LA50_RS07245	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LA50_RS07250	COG2011	ABC-type metal ion transport system permease component
LA50_RS07255	COG1464	Belongs to the NlpA lipoprotein family
LA50_RS07290	COG0356	it plays a direct role in the translocation of protons across the membrane
LA50_RS07350	COG1216	Glycosyl transferase, family 2
LA50_RS07370	COG1385	rRNA (uridine-N3-)-methyltransferase activity
LA50_RS07395	COG0583	DNA-binding transcription factor activity
LA50_RS07400	COG2259	Doxx family
LA50_RS07420	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LA50_RS07425	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LA50_RS07470	COG1555	photosystem II stabilization
LA50_RS07470	COG1596	polysaccharide export
LA50_RS07490	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LA50_RS07500	COG2954	triphosphatase activity
LA50_RS07505	COG1981	membrane
LA50_RS07535	COG0739	heme binding
LA50_RS07540	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
LA50_RS07590	COG0142	geranyltranstransferase activity
LA50_RS07650	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LA50_RS07665	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
LA50_RS07690	COG2350	Protein conserved in bacteria
LA50_RS07715	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LA50_RS07740	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
LA50_RS07750	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
LA50_RS07755	COG1137	ATPase activity
LA50_RS07785	COG2814	Major facilitator Superfamily
LA50_RS07880	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LA50_RS07885	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LA50_RS07890	COG0583	DNA-binding transcription factor activity
LA50_RS07910	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
LA50_RS07915	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
LA50_RS07920	COG0488	(ABC) transporter
LA50_RS07930	COG2017	converts alpha-aldose to the beta-anomer
LA50_RS07940	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LA50_RS07985	COG0708	Exodeoxyribonuclease III
LA50_RS08015	COG2960	long-chain fatty acid transporting porin activity
LA50_RS08080	COG2194	sulfuric ester hydrolase activity
LA50_RS08085	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LA50_RS08145	COG2252	PERMEase
LA50_RS08160	COG0372	Belongs to the citrate synthase family
LA50_RS08170	COG5505	Protein of unknown function (DUF819)
LA50_RS08180	COG2828	Protein conserved in bacteria
LA50_RS08190	COG0009	L-threonylcarbamoyladenylate synthase
LA50_RS08195	COG1959	2 iron, 2 sulfur cluster binding
LA50_RS08210	COG0287	Prephenate dehydrogenase
LA50_RS08215	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LA50_RS08270	COG0697	spore germination
LA50_RS08275	COG2814	Major facilitator Superfamily
LA50_RS08335	COG0802	atpase or kinase
LA50_RS08410	COG0471	metal ion transport
LA50_RS08415	COG1376	ErfK ybiS ycfS ynhG family protein
LA50_RS08420	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LA50_RS08430	COG2830	Protein of unknown function (DUF452)
LA50_RS08435	COG0500	methyltransferase
LA50_RS08520	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LA50_RS08525	COG1538	Outer membrane efflux protein
LA50_RS08535	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LA50_RS08540	COG2999	glutathione oxidoreductase activity
LA50_RS08555	COG1994	Peptidase M50
LA50_RS08575	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LA50_RS08575	COG3453	Protein conserved in bacteria
LA50_RS08585	COG3278	Belongs to the heme-copper respiratory oxidase family
LA50_RS08600	COG2010	Cytochrome c
LA50_RS08610	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
LA50_RS08615	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
LA50_RS08650	COG1620	l-lactate permease
LA50_RS08670	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
LA50_RS08690	COG0733	neurotransmitter:sodium symporter activity
LA50_RS08720	COG3676	manually curated
LA50_RS08755	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
LA50_RS08770	COG0586	Pfam SNARE associated Golgi protein
LA50_RS08775	COG0252	asparaginase activity
LA50_RS08790	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LA50_RS08835	COG3245	cytochrome
LA50_RS08875	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
LA50_RS08875	COG3008	intermembrane lipid transfer
LA50_RS08880	COG2995	paraquat-inducible protein a
LA50_RS08915	COG0826	peptidase U32
LA50_RS08925	COG0561	phosphatase activity
LA50_RS08945	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LA50_RS08950	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LA50_RS08985	COG1555	photosystem II stabilization
LA50_RS08985	COG1596	polysaccharide export
LA50_RS09045	COG1115	amino acid carrier protein
LA50_RS09050	COG1272	protein, Hemolysin III
LA50_RS09060	COG1160	GTP binding
LA50_RS09090	COG2194	sulfuric ester hydrolase activity
LA50_RS09095	COG0778	Nitroreductase
LA50_RS09110	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LA50_RS09140	COG1619	proteins homologs of microcin C7 resistance protein MccF
LA50_RS09180	COG0351	phosphomethylpyrimidine kinase
LA50_RS09200	COG0569	domain protein
LA50_RS09255	COG5002	protein histidine kinase activity
LA50_RS09270	COG1275	C4-dicarboxylate transporter malic acid transport protein
LA50_RS09280	COG3547	Transposase (IS116 IS110 IS902 family)
LA50_RS09330	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LA50_RS09340	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LA50_RS09375	COG0616	signal peptide processing
LA50_RS09400	COG2084	Dehydrogenase
LA50_RS09430	COG1999	signal sequence binding
LA50_RS09440	COG0028	Belongs to the TPP enzyme family
LA50_RS09465	COG1049	propionate catabolic process, 2-methylcitrate cycle
LA50_RS09495	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
LA50_RS09505	COG1765	OsmC-like protein
LA50_RS09510	COG1802	Transcriptional regulator
LA50_RS09515	COG2431	L-lysine efflux transmembrane transporter activity
LA50_RS09520	COG1349	DNA-binding transcription factor activity
LA50_RS09550	COG0318	PFAM AMP-dependent synthetase and ligase
LA50_RS09625	COG3945	hemerythrin HHE cation binding domain
LA50_RS09640	COG1881	PFAM PEBP family protein
LA50_RS09645	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LA50_RS09655	COG0859	PFAM glycosyl transferase family 9
LA50_RS09670	COG0277	FAD linked oxidase domain protein
LA50_RS09690	COG1562	ergosterol biosynthetic process
LA50_RS09755	COG0765	amino acid transport
LA50_RS09790	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
LA50_RS09835	COG1966	Carbon starvation protein
LA50_RS09865	COG1253	flavin adenine dinucleotide binding
LA50_RS09880	COG1607	acyl-coa hydrolase
LA50_RS09920	COG1942	4-Oxalocrotonate Tautomerase
LA50_RS09925	COG0436	Aminotransferase
LA50_RS09965	COG1943	Transposase
LA50_RS09985	COG1196	nuclear chromosome segregation
LA50_RS09985	COG0739	heme binding
LA50_RS09985	COG0741	lytic transglycosylase activity
LA50_RS09990	COG2814	Major facilitator Superfamily
LA50_RS10000	COG0697	spore germination
LA50_RS10010	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
LA50_RS10025	COG0348	domain, Protein
LA50_RS10035	COG2070	2-Nitropropane dioxygenase
LA50_RS10080	COG0210	DNA helicase
LA50_RS10120	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
LA50_RS10145	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
LA50_RS10150	COG1139	Iron-sulfur cluster binding protein
LA50_RS10160	COG0247	lactate metabolic process
LA50_RS10165	COG0477	Major facilitator Superfamily
LA50_RS10170	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LA50_RS10175	COG0791	NLP P60 protein
LA50_RS10245	COG0513	Belongs to the DEAD box helicase family
LA50_RS10255	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LA50_RS10270	COG1560	Kdo2-lipid A biosynthetic process
LA50_RS10285	COG0308	aminopeptidase N
LA50_RS10315	COG3676	manually curated
LA50_RS10340	COG1194	a g-specific adenine glycosylase
LA50_RS10350	COG0800	Aldolase
LA50_RS10360	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
LA50_RS10375	COG1737	Transcriptional regulator
LA50_RS10420	COG3036	rescue of stalled ribosome
LA50_RS10430	COG0822	iron-sulfur transferase activity
LA50_RS10455	COG1304	FMN binding
LA50_RS10460	COG3421	Type III restriction
LA50_RS10465	COG2189	Belongs to the N(4) N(6)-methyltransferase family
LA50_RS10470	COG2189	Belongs to the N(4) N(6)-methyltransferase family
LA50_RS10515	COG0513	Belongs to the DEAD box helicase family
LA50_RS10540	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
LA50_RS10565	COG0543	2 iron, 2 sulfur cluster binding
LA50_RS10565	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LA50_RS10575	COG2990	Protein conserved in bacteria
LA50_RS10590	COG2095	MarC family integral membrane protein
LA50_RS10595	COG1012	belongs to the aldehyde dehydrogenase family
LA50_RS10605	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LA50_RS10605	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LA50_RS10615	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
LA50_RS10635	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LA50_RS10640	COG0508	dehydrogenase complex catalyzes the overall conversion of
LA50_RS10645	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
LA50_RS10660	COG0179	Fumarylacetoacetate (FAA) hydrolase
LA50_RS10675	COG3045	CreA protein
LA50_RS10690	COG0793	Belongs to the peptidase S41A family
LA50_RS10720	COG2217	Heavy metal translocating P-type atpase
LA50_RS10725	COG0492	ferredoxin-NADP+ reductase activity
LA50_RS10750	COG0730	response to heat
LA50_RS10755	COG1183	phosphatidylcholine synthase activity
LA50_RS10815	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
LA50_RS10820	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
LA50_RS10825	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
LA50_RS10830	COG0789	Transcriptional regulator
LA50_RS10860	COG0741	lytic transglycosylase activity
LA50_RS10860	COG1388	LysM domain
LA50_RS10885	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LA50_RS10895	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LA50_RS10900	COG0633	Ferredoxin
LA50_RS10930	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LA50_RS10940	COG2951	lytic endotransglycosylase activity
LA50_RS10950	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LA50_RS10955	COG0318	PFAM AMP-dependent synthetase and ligase
LA50_RS10985	COG2608	mercury ion transmembrane transporter activity
LA50_RS10990	COG4797	methyltransferase
LA50_RS10990	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LA50_RS11005	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LA50_RS11015	COG0523	cobalamin synthesis protein
LA50_RS11020	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LA50_RS11045	COG0251	oxidation-reduction process
LA50_RS11060	COG0697	spore germination
LA50_RS11065	COG1027	Aspartate ammonia-lyase
LA50_RS11070	COG2353	YceI-like domain
LA50_RS11120	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
LA50_RS11130	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LA50_RS11135	COG2217	Heavy metal translocating P-type atpase
LA50_RS11170	COG0583	DNA-binding transcription factor activity
LA50_RS11185	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LA50_RS11205	COG1216	Glycosyl transferase, family 2
LA50_RS11235	COG2197	response regulator
LA50_RS11240	COG3850	Histidine kinase
LA50_RS11250	COG0307	riboflavin synthase, alpha
LA50_RS11270	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LA50_RS11290	COG0488	(ABC) transporter
LA50_RS11295	COG1393	Belongs to the ArsC family
LA50_RS11330	COG2890	protein-(glutamine-N5) methyltransferase activity
LA50_RS11335	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
LA50_RS11360	COG0488	(ABC) transporter