locus-tag	class	description
H7A79_RS00060	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H7A79_RS00065	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
H7A79_RS00075	COG1177	transmembrane transport
H7A79_RS00080	COG1176	ABC-type spermidine putrescine transport system, permease component I
H7A79_RS00085	COG3842	ATPase activity
H7A79_RS00100	COG0643	Histidine kinase
H7A79_RS00100	COG2198	Histidine kinase
H7A79_RS00105	COG2201	protein-glutamate methylesterase activity
H7A79_RS00120	COG0826	peptidase U32
H7A79_RS00130	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H7A79_RS00130	COG0512	Glutamine amidotransferase of anthranilate synthase
H7A79_RS00155	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
H7A79_RS00165	COG2801	Transposase and inactivated derivatives
H7A79_RS00205	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H7A79_RS00215	COG1505	serine-type exopeptidase activity
H7A79_RS00220	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
H7A79_RS00235	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H7A79_RS00245	COG0833	amino acid
H7A79_RS00250	COG1253	flavin adenine dinucleotide binding
H7A79_RS00255	COG1994	Peptidase M50
H7A79_RS00260	COG3340	Belongs to the peptidase S51 family
H7A79_RS00265	COG0009	L-threonylcarbamoyladenylate synthase
H7A79_RS00290	COG0613	PHP domain protein
H7A79_RS00300	COG2501	S4 domain
H7A79_RS00305	COG0753	catalase activity
H7A79_RS00310	COG1530	ribonuclease E activity
H7A79_RS00315	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H7A79_RS00320	COG1333	cytochrome c biogenesis protein
H7A79_RS00335	COG2818	Glycosylase
H7A79_RS00355	COG3676	manually curated
H7A79_RS00385	COG1555	photosystem II stabilization
H7A79_RS00415	COG4263	nitrous-oxide reductase activity
H7A79_RS00430	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
H7A79_RS00515	COG0582	viral genome integration into host DNA
H7A79_RS00565	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H7A79_RS00580	COG3676	manually curated
H7A79_RS00620	COG2801	Transposase and inactivated derivatives
H7A79_RS00625	COG1053	succinate dehydrogenase
H7A79_RS00630	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H7A79_RS00635	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
H7A79_RS00655	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H7A79_RS00665	COG3256	nitric oxide reductase
H7A79_RS00680	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
H7A79_RS00685	COG0508	dehydrogenase complex catalyzes the overall conversion of
H7A79_RS00695	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H7A79_RS00710	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7A79_RS00715	COG0765	amino acid transport
H7A79_RS00720	COG1126	abc transporter atp-binding protein
H7A79_RS00730	COG2867	negative regulation of translational initiation
H7A79_RS00805	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H7A79_RS00860	COG3676	manually curated
H7A79_RS00865	COG3676	manually curated
H7A79_RS00870	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H7A79_RS00895	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
H7A79_RS00905	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
H7A79_RS00910	COG3052	prosthetic group binding
H7A79_RS00915	COG2301	Belongs to the HpcH HpaI aldolase family
H7A79_RS00920	COG3051	citrate lyase alpha subunit
H7A79_RS00930	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
H7A79_RS00940	COG0488	(ABC) transporter
H7A79_RS00995	COG2801	Transposase and inactivated derivatives
H7A79_RS01015	COG2431	L-lysine efflux transmembrane transporter activity
H7A79_RS01065	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
H7A79_RS01145	COG3210	domain, Protein
H7A79_RS01155	COG3210	domain, Protein
H7A79_RS01160	COG2831	hemolysin activation secretion protein
H7A79_RS01165	COG3676	manually curated
H7A79_RS01230	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
H7A79_RS01230	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H7A79_RS01240	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
H7A79_RS01250	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H7A79_RS01255	COG1765	OsmC-like protein
H7A79_RS01265	COG2878	Part of a membrane complex involved in electron transport
H7A79_RS01280	COG0277	FAD linked oxidase domain protein
H7A79_RS01285	COG1882	Formate acetyltransferase
H7A79_RS01290	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
H7A79_RS01295	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H7A79_RS01300	COG0741	lytic transglycosylase activity
H7A79_RS01400	COG2217	Heavy metal translocating P-type atpase
H7A79_RS01430	COG0204	Acyl-transferase
H7A79_RS01440	COG0038	chloride channel
H7A79_RS01450	COG3676	manually curated
H7A79_RS01455	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H7A79_RS01460	COG0477	Major facilitator Superfamily
H7A79_RS01595	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H7A79_RS01640	COG1116	anion transmembrane transporter activity
H7A79_RS01640	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H7A79_RS01645	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H7A79_RS01665	COG2833	Protein of unknown function (DUF455)
H7A79_RS01680	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
H7A79_RS01690	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H7A79_RS01695	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H7A79_RS01705	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H7A79_RS01710	COG0633	Ferredoxin
H7A79_RS01715	COG3676	manually curated
H7A79_RS01880	COG2801	Transposase and inactivated derivatives
H7A79_RS01895	COG1126	abc transporter atp-binding protein
H7A79_RS01965	COG0678	peroxiredoxin activity
H7A79_RS01965	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H7A79_RS01970	COG0307	riboflavin synthase, alpha
H7A79_RS01975	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H7A79_RS01980	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H7A79_RS01985	COG3676	manually curated
H7A79_RS02015	COG0521	Mo-molybdopterin cofactor biosynthetic process
H7A79_RS02030	COG1064	alcohol dehydrogenase
H7A79_RS02045	COG1561	YicC-like family, N-terminal region
H7A79_RS02055	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H7A79_RS02090	COG0582	viral genome integration into host DNA
H7A79_RS02100	COG0582	viral genome integration into host DNA
H7A79_RS02120	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H7A79_RS02130	COG1610	YqeY-like protein
H7A79_RS02135	COG1715	Restriction endonuclease
H7A79_RS02150	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H7A79_RS02160	COG0628	permease
H7A79_RS02220	COG1028	Short-chain dehydrogenase reductase Sdr
H7A79_RS02230	COG3676	manually curated
H7A79_RS02305	COG4174	ABC transporter (Permease)
H7A79_RS02315	COG4239	(ABC) transporter, permease
H7A79_RS02320	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
H7A79_RS02355	COG0805	protein transport
H7A79_RS02365	COG0318	PFAM AMP-dependent synthetase and ligase
H7A79_RS02380	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H7A79_RS02400	COG0280	phosphate acetyltransferase
H7A79_RS02400	COG0281	malic enzyme
H7A79_RS02410	COG3676	manually curated
H7A79_RS02450	COG0745	RESPONSE REGULATOR receiver
H7A79_RS02455	COG2205	protein histidine kinase activity
H7A79_RS02505	COG4172	Belongs to the ABC transporter superfamily
H7A79_RS02515	COG0741	lytic transglycosylase activity
H7A79_RS02530	COG3451	type IV secretory pathway VirB4
H7A79_RS02600	COG4453	Protein conserved in bacteria
H7A79_RS02715	COG2337	Toxic component of a toxin-antitoxin (TA) module
H7A79_RS02750	COG3620	sequence-specific DNA binding
H7A79_RS02780	COG3676	manually curated
H7A79_RS02795	COG0582	viral genome integration into host DNA
H7A79_RS02800	COG1686	Belongs to the peptidase S11 family
H7A79_RS02815	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H7A79_RS02820	COG3318	Belongs to the UPF0149 family
H7A79_RS02820	COG3012	SEC-C Motif Domain Protein
H7A79_RS02825	COG1496	oxidoreductase activity
H7A79_RS02840	COG1012	belongs to the aldehyde dehydrogenase family
H7A79_RS02845	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H7A79_RS02860	COG3411	Ferredoxin
H7A79_RS02910	COG0039	L-malate dehydrogenase activity
H7A79_RS02915	COG2009	succinate dehydrogenase
H7A79_RS02925	COG1053	succinate dehydrogenase
H7A79_RS02930	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H7A79_RS02935	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
H7A79_RS02945	COG0567	Dehydrogenase, E1 component
H7A79_RS02950	COG0508	dehydrogenase complex catalyzes the overall conversion of
H7A79_RS02960	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H7A79_RS02975	COG0523	cobalamin synthesis protein
H7A79_RS02980	COG3422	double-strand break repair
H7A79_RS02985	COG0560	Phosphoserine phosphatase
H7A79_RS02990	COG1028	Short-chain dehydrogenase reductase Sdr
H7A79_RS03000	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
H7A79_RS03020	COG1737	Transcriptional regulator
H7A79_RS03035	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
H7A79_RS03045	COG0800	Aldolase
H7A79_RS03065	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H7A79_RS03080	COG1337	RAMP superfamily
H7A79_RS03110	COG1309	transcriptional regulator
H7A79_RS03140	COG0564	pseudouridine synthase activity
H7A79_RS03150	COG1530	ribonuclease E activity
H7A79_RS03165	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H7A79_RS03170	COG0483	inositol monophosphate 1-phosphatase activity
H7A79_RS03175	COG1166	arginine decarboxylase activity
H7A79_RS03210	COG1555	photosystem II stabilization
H7A79_RS03220	COG1546	Belongs to the CinA family
H7A79_RS03220	COG1058	Belongs to the CinA family
H7A79_RS03235	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H7A79_RS03250	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H7A79_RS03270	COG0667	Aldo Keto reductase
H7A79_RS03280	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H7A79_RS03285	COG0803	Belongs to the bacterial solute-binding protein 9 family
H7A79_RS03290	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H7A79_RS03295	COG0733	neurotransmitter:sodium symporter activity
H7A79_RS03315	COG0612	Peptidase, M16
H7A79_RS03320	COG2095	MarC family integral membrane protein
H7A79_RS03330	COG0772	Belongs to the SEDS family
H7A79_RS03335	COG0768	penicillin binding
H7A79_RS03340	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
H7A79_RS03345	COG1792	Involved in formation and maintenance of cell shape
H7A79_RS03350	COG1077	Cell shape determining protein MreB Mrl
H7A79_RS03365	COG3676	manually curated
H7A79_RS03390	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H7A79_RS03415	COG0488	(ABC) transporter
H7A79_RS03465	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
H7A79_RS03495	COG0583	DNA-binding transcription factor activity
H7A79_RS03500	COG2259	Doxx family
H7A79_RS03515	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H7A79_RS03535	COG0488	(ABC) transporter
H7A79_RS03555	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
H7A79_RS03575	COG0732	type I restriction modification DNA specificity domain
H7A79_RS03580	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
H7A79_RS03620	COG0347	Belongs to the P(II) protein family
H7A79_RS03650	COG1686	Belongs to the peptidase S11 family
H7A79_RS03655	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H7A79_RS03660	COG0133	tryptophan synthase activity
H7A79_RS03700	COG0210	DNA helicase
H7A79_RS03720	COG1192	Involved in chromosome partitioning
H7A79_RS03850	COG3621	Patatin-like phospholipase
H7A79_RS03890	COG2189	Belongs to the N(4) N(6)-methyltransferase family
H7A79_RS03910	COG3676	manually curated
H7A79_RS04000	COG3676	manually curated
H7A79_RS04020	COG5293	efflux transmembrane transporter activity
H7A79_RS04140	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H7A79_RS04195	COG3676	manually curated
H7A79_RS04245	COG1194	a g-specific adenine glycosylase
H7A79_RS04255	COG1187	pseudouridine synthase activity
H7A79_RS04265	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H7A79_RS04275	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
H7A79_RS04295	COG1272	protein, Hemolysin III
H7A79_RS04300	COG1970	mechanosensitive ion channel activity
H7A79_RS04315	COG0287	Prephenate dehydrogenase
H7A79_RS04325	COG0668	transmembrane transport
H7A79_RS04330	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H7A79_RS04335	COG3676	manually curated
H7A79_RS04400	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H7A79_RS04410	COG2608	mercury ion transmembrane transporter activity
H7A79_RS04415	COG2217	Heavy metal translocating P-type atpase
H7A79_RS04420	COG0497	DNA recombination
H7A79_RS04425	COG0251	oxidation-reduction process
H7A79_RS04435	COG1027	Aspartate ammonia-lyase
H7A79_RS04440	COG0730	response to heat
H7A79_RS04445	COG1183	phosphatidylcholine synthase activity
H7A79_RS04455	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
H7A79_RS04490	COG0179	Fumarylacetoacetate (FAA) hydrolase
H7A79_RS04495	COG0084	hydrolase, TatD family'
H7A79_RS04500	COG3676	manually curated
H7A79_RS04510	COG3568	Endonuclease Exonuclease Phosphatase
H7A79_RS04585	COG1428	Deoxynucleoside kinase
H7A79_RS04595	COG3094	Invasion gene expression up-regulator, SirB
H7A79_RS04645	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
H7A79_RS04650	COG5266	PFAM Nickel transport complex, NikM subunit, transmembrane
H7A79_RS04655	COG1858	cytochrome C peroxidase
H7A79_RS04740	COG1477	protein flavinylation
H7A79_RS04745	COG2991	Protein conserved in bacteria
H7A79_RS04785	COG2369	cell adhesion
H7A79_RS04810	COG0456	acetyltransferase
H7A79_RS04815	COG1214	PFAM Peptidase M22, glycoprotease
H7A79_RS04820	COG0714	Associated with various cellular activities
H7A79_RS04845	COG3676	manually curated
H7A79_RS04860	COG1187	pseudouridine synthase activity
H7A79_RS04915	COG0492	ferredoxin-NADP+ reductase activity
H7A79_RS04920	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H7A79_RS04930	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
H7A79_RS04975	COG0110	maltose O-acetyltransferase activity
H7A79_RS04980	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H7A79_RS04990	COG1454	alcohol dehydrogenase
H7A79_RS04990	COG1012	belongs to the aldehyde dehydrogenase family
H7A79_RS05005	COG1028	Short-chain dehydrogenase reductase Sdr
H7A79_RS05040	COG3008	intermembrane lipid transfer
H7A79_RS05040	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H7A79_RS05045	COG2995	paraquat-inducible protein a
H7A79_RS05050	COG1704	LemA family
H7A79_RS05065	COG2226	methyltransferase
H7A79_RS05070	COG1388	LysM domain
H7A79_RS05070	COG1388	LysM domain
H7A79_RS05070	COG0741	lytic transglycosylase activity
H7A79_RS05070	COG0741	lytic transglycosylase activity
H7A79_RS05145	COG3676	manually curated
H7A79_RS05160	COG3676	manually curated
H7A79_RS05420	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H7A79_RS05440	COG4373	Mu-like prophage FluMu protein gp28
H7A79_RS05445	COG4383	Mu-like prophage protein gp29
H7A79_RS05450	COG2369	cell adhesion
H7A79_RS05455	COG5005	Phage virion morphogenesis
H7A79_RS05475	COG2369	cell adhesion
H7A79_RS05500	COG2879	small protein
H7A79_RS05505	COG1966	Carbon starvation protein
H7A79_RS05520	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H7A79_RS05545	COG0538	isocitrate dehydrogenase activity
H7A79_RS05550	COG1187	pseudouridine synthase activity
H7A79_RS05590	COG2841	Protein conserved in bacteria
H7A79_RS05595	COG0778	Nitroreductase
H7A79_RS05600	COG1562	ergosterol biosynthetic process
H7A79_RS05660	COG0730	response to heat
H7A79_RS05695	COG0673	inositol 2-dehydrogenase activity
H7A79_RS05705	COG0859	PFAM glycosyl transferase family 9
H7A79_RS05720	COG3392	D12 class N6 adenine-specific DNA methyltransferase
H7A79_RS05800	COG4386	tail sheath protein
H7A79_RS05825	COG4397	Mu-like prophage major head subunit gpT
H7A79_RS05830	COG4388	Caudovirus prohead serine protease
H7A79_RS05835	COG5005	Phage virion morphogenesis
H7A79_RS05840	COG2369	cell adhesion
H7A79_RS05845	COG4383	Mu-like prophage protein gp29
H7A79_RS05915	COG1598	PFAM Uncharacterised protein family UPF0150
H7A79_RS05920	COG1724	mRNA binding
H7A79_RS05945	COG4396	Host-nuclease inhibitor protein Gam
H7A79_RS06045	COG0697	spore germination
H7A79_RS06070	COG0793	Belongs to the peptidase S41A family
H7A79_RS06090	COG0633	Ferredoxin
H7A79_RS06105	COG2017	converts alpha-aldose to the beta-anomer
H7A79_RS06115	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H7A79_RS06145	COG0494	nUDIX hydrolase
H7A79_RS06160	COG1957	nucleoside hydrolase
H7A79_RS06195	COG0330	HflC and HflK could
H7A79_RS06215	COG2814	Major facilitator Superfamily
H7A79_RS06240	COG0248	Ppx GppA phosphatase
H7A79_RS06275	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H7A79_RS06285	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H7A79_RS06285	COG0475	glutathione-regulated potassium exporter activity
H7A79_RS06290	COG4178	(ABC) transporter
H7A79_RS06295	COG4774	siderophore transport
H7A79_RS06310	COG3059	membrane
H7A79_RS06315	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H7A79_RS06340	COG1335	isochorismatase
H7A79_RS06365	COG0431	NADPH-dependent FMN reductase
H7A79_RS06380	COG0252	asparaginase activity
H7A79_RS06385	COG2975	iron-sulfur cluster assembly
H7A79_RS06400	COG5510	response to toxic substance
H7A79_RS06430	COG2165	general secretion pathway protein
H7A79_RS06435	COG0305	Participates in initiation and elongation during chromosome replication
H7A79_RS06445	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H7A79_RS06455	COG3676	manually curated
H7A79_RS06575	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H7A79_RS06600	COG3676	manually curated
H7A79_RS06615	COG0557	exoribonuclease II activity
H7A79_RS06625	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H7A79_RS06630	COG2951	lytic endotransglycosylase activity
H7A79_RS06640	COG3676	manually curated
H7A79_RS06670	COG0408	coproporphyrinogen oxidase activity
H7A79_RS06675	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H7A79_RS06680	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H7A79_RS06690	COG0626	cystathionine gamma-synthase activity
H7A79_RS06695	COG0583	DNA-binding transcription factor activity
H7A79_RS06705	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H7A79_RS06720	COG0285	dihydrofolate synthase activity
H7A79_RS06730	COG1286	toxin biosynthetic process
H7A79_RS06735	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
H7A79_RS06760	COG0513	Belongs to the DEAD box helicase family
H7A79_RS06775	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H7A79_RS06800	COG1309	transcriptional regulator
H7A79_RS06810	COG0300	oxidoreductase activity
H7A79_RS06815	COG0702	epimerase
H7A79_RS06835	COG0123	including yeast histone deacetylase and acetoin utilization protein
H7A79_RS06840	COG1862	Preprotein translocase
H7A79_RS06845	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H7A79_RS06850	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H7A79_RS06870	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
H7A79_RS06895	COG0586	Pfam SNARE associated Golgi protein
H7A79_RS06900	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H7A79_RS06900	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H7A79_RS06910	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
H7A79_RS06935	COG0471	metal ion transport
H7A79_RS06960	COG3676	manually curated
H7A79_RS06990	COG3676	manually curated
H7A79_RS07010	COG0366	Alpha amylase catalytic
H7A79_RS07020	COG1959	2 iron, 2 sulfur cluster binding
H7A79_RS07040	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H7A79_RS07050	COG0720	synthase
H7A79_RS07055	COG3759	membrane
H7A79_RS07075	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H7A79_RS07095	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H7A79_RS07105	COG0786	glutamate:sodium symporter activity
H7A79_RS07120	COG0471	metal ion transport
H7A79_RS07130	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H7A79_RS07150	COG0728	peptidoglycan biosynthetic process
H7A79_RS07220	COG3219	Protein conserved in bacteria
H7A79_RS07240	COG2259	Doxx family
H7A79_RS07245	COG3945	hemerythrin HHE cation binding domain
H7A79_RS07350	COG3676	manually curated
H7A79_RS07365	COG2274	protein secretion by the type I secretion system
H7A79_RS07445	COG0277	FAD linked oxidase domain protein
H7A79_RS07465	COG1064	alcohol dehydrogenase
H7A79_RS07480	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H7A79_RS07485	COG2814	Major facilitator Superfamily
H7A79_RS07490	COG2116	formate transmembrane transporter activity
H7A79_RS07505	COG1448	Aminotransferase
H7A79_RS07510	COG0058	SHG alpha-glucan phosphorylase activity
H7A79_RS07515	COG0297	glycogen (starch) synthase activity
H7A79_RS07530	COG1523	belongs to the glycosyl hydrolase 13 family
H7A79_RS07580	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
H7A79_RS07595	COG0745	RESPONSE REGULATOR receiver
H7A79_RS07595	COG2972	Histidine kinase
H7A79_RS07600	COG2321	neutral zinc metallopeptidase
H7A79_RS07605	COG0010	Belongs to the arginase family
H7A79_RS07610	COG0586	Pfam SNARE associated Golgi protein
H7A79_RS07635	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H7A79_RS07675	COG2350	Protein conserved in bacteria
H7A79_RS07695	COG3676	manually curated
H7A79_RS07715	COG0488	(ABC) transporter
H7A79_RS07725	COG3245	cytochrome
H7A79_RS07735	COG0028	Belongs to the TPP enzyme family
H7A79_RS07740	COG0440	acetolactate synthase activity
H7A79_RS07750	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
H7A79_RS07755	COG0436	Aminotransferase
H7A79_RS07770	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H7A79_RS07770	COG2813	Specifically methylates the guanine in position
H7A79_RS07775	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H7A79_RS07780	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
H7A79_RS07805	COG0617	tRNA 3'-terminal CCA addition
H7A79_RS07815	COG3084	Protein conserved in bacteria
H7A79_RS07820	COG1074	ATP-dependent DNA helicase activity
H7A79_RS07835	COG1217	gtp-binding protein TYPA
H7A79_RS07865	COG1538	Outer membrane efflux protein
H7A79_RS07870	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H7A79_RS07875	COG0084	hydrolase, TatD family'
H7A79_RS07890	COG2315	Protein conserved in bacteria
H7A79_RS07910	COG1999	signal sequence binding
H7A79_RS07945	COG4942	peptidase
H7A79_RS07955	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H7A79_RS07965	COG0802	atpase or kinase
H7A79_RS08005	COG0616	signal peptide processing
H7A79_RS08005	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H7A79_RS08010	COG1643	Atp-dependent helicase
H7A79_RS08020	COG1396	sequence-specific DNA binding
H7A79_RS08030	COG1643	Atp-dependent helicase
H7A79_RS08040	COG0791	NLP P60 protein
H7A79_RS08050	COG1380	Effector of murein hydrolase LrgA
H7A79_RS08055	COG1346	cytolysis
H7A79_RS08060	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H7A79_RS08070	COG0315	cyclic pyranopterin monophosphate synthase activity
H7A79_RS08075	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H7A79_RS08085	COG3676	manually curated
H7A79_RS08100	COG2837	iron assimilation
H7A79_RS08105	COG1408	metallophosphoesterase
H7A79_RS08125	COG2866	Carboxypeptidase
H7A79_RS08165	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
H7A79_RS08170	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
H7A79_RS08210	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H7A79_RS08230	COG2999	glutathione oxidoreductase activity
H7A79_RS08250	COG3265	gluconokinase activity
H7A79_RS08255	COG3676	manually curated
H7A79_RS08260	COG2610	gluconate transmembrane transporter activity
H7A79_RS08265	COG0569	domain protein
H7A79_RS08275	COG0708	Exodeoxyribonuclease III
H7A79_RS08285	COG0339	signal peptide processing
H7A79_RS08340	COG3676	manually curated
H7A79_RS08385	COG3676	manually curated
H7A79_RS08420	COG1724	mRNA binding
H7A79_RS08425	COG1598	PFAM Uncharacterised protein family UPF0150
H7A79_RS08485	COG0741	lytic transglycosylase activity
H7A79_RS08485	COG1196	nuclear chromosome segregation
H7A79_RS08485	COG0739	heme binding
H7A79_RS08520	COG1724	mRNA binding
H7A79_RS08525	COG1598	PFAM Uncharacterised protein family UPF0150
H7A79_RS08560	COG4695	Portal protein
H7A79_RS08655	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H7A79_RS08665	COG1724	mRNA binding
H7A79_RS08670	COG1598	PFAM Uncharacterised protein family UPF0150
H7A79_RS08710	COG0681	Belongs to the peptidase S26 family
H7A79_RS08725	COG2801	Transposase and inactivated derivatives
H7A79_RS08750	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
H7A79_RS08790	COG0494	nUDIX hydrolase
H7A79_RS08800	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H7A79_RS08815	COG0385	Bile acid
H7A79_RS08825	COG1702	phosphate starvation-inducible protein PhoH
H7A79_RS08920	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H7A79_RS08925	COG0280	phosphate acetyltransferase
H7A79_RS08925	COG0857	belongs to the CobB CobQ family
H7A79_RS09035	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H7A79_RS09045	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H7A79_RS09045	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H7A79_RS09085	COG0438	transferase activity, transferring glycosyl groups
H7A79_RS09100	COG0438	transferase activity, transferring glycosyl groups
H7A79_RS09110	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H7A79_RS09125	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H7A79_RS09130	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H7A79_RS09145	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H7A79_RS09165	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
H7A79_RS09190	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
H7A79_RS09215	COG0288	reversible hydration of carbon dioxide
H7A79_RS09225	COG0799	negative regulation of ribosome biogenesis
H7A79_RS09235	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H7A79_RS09245	COG0582	viral genome integration into host DNA
H7A79_RS09300	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H7A79_RS09335	COG0582	viral genome integration into host DNA
H7A79_RS09450	COG2070	2-Nitropropane dioxygenase
H7A79_RS09465	COG2369	cell adhesion
H7A79_RS09490	COG1160	GTP binding
H7A79_RS09530	COG1704	LemA family
H7A79_RS09535	COG1088	dTDP-glucose 4,6-dehydratase activity
H7A79_RS09560	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
H7A79_RS09625	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
H7A79_RS09630	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
H7A79_RS09640	COG1215	transferase activity, transferring glycosyl groups
H7A79_RS09680	COG1024	Enoyl-CoA hydratase
H7A79_RS09700	COG3104	oligopeptide transport
H7A79_RS09705	COG0561	phosphatase activity
H7A79_RS09745	COG1012	belongs to the aldehyde dehydrogenase family
H7A79_RS09755	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
H7A79_RS09770	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H7A79_RS09790	COG0406	alpha-ribazole phosphatase activity
H7A79_RS09820	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H7A79_RS09825	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H7A79_RS09830	COG1127	ABC transporter
H7A79_RS09865	COG3384	dioxygenase
H7A79_RS09870	COG0489	protein tyrosine kinase activity
H7A79_RS09885	COG2252	PERMEase
H7A79_RS09930	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H7A79_RS09960	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H7A79_RS09970	COG2204	response regulator
H7A79_RS09975	COG5000	phosphorelay sensor kinase activity
H7A79_RS09985	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H7A79_RS09985	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H7A79_RS10005	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H7A79_RS10005	COG0758	DNA mediated transformation
H7A79_RS10030	COG0742	ribosomal rna small subunit methyltransferase
H7A79_RS10035	COG0814	amino acid
H7A79_RS10040	COG1760	l-serine dehydratase
H7A79_RS10045	COG0514	ATP-dependent DNA helicase (RecQ)
H7A79_RS10070	COG0612	Peptidase, M16
H7A79_RS10085	COG2884	Cell division ATP-binding protein ftsE
H7A79_RS10115	COG0436	Aminotransferase
H7A79_RS10125	COG3676	manually curated
H7A79_RS10140	COG0708	Exodeoxyribonuclease III
H7A79_RS10165	COG2233	PERMEase
H7A79_RS10175	COG0439	Biotin carboxylase
H7A79_RS10180	COG0511	ligase activity, forming carbon-carbon bonds
H7A79_RS10200	COG1794	racemase activity, acting on amino acids and derivatives
H7A79_RS10230	COG2832	Protein of unknown function (DUF454)
H7A79_RS10295	COG0814	amino acid
H7A79_RS10315	COG2119	membrane
H7A79_RS10355	COG1289	transmembrane transporter activity
H7A79_RS10360	COG0861	Integral membrane protein TerC family
H7A79_RS10380	COG0583	DNA-binding transcription factor activity
H7A79_RS10395	COG4166	transmembrane transport
H7A79_RS10400	COG1560	Kdo2-lipid A biosynthetic process
H7A79_RS10475	COG2337	Toxic component of a toxin-antitoxin (TA) module
H7A79_RS10495	COG3620	sequence-specific DNA binding
H7A79_RS10525	COG3676	manually curated
H7A79_RS10585	COG2801	Transposase and inactivated derivatives
H7A79_RS10640	COG1045	serine acetyltransferase
H7A79_RS10695	COG1247	-acetyltransferase
H7A79_RS10715	COG0557	exoribonuclease II activity
H7A79_RS10815	COG0356	it plays a direct role in the translocation of protons across the membrane
H7A79_RS10850	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
H7A79_RS10940	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
H7A79_RS10965	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H7A79_RS10970	COG1132	(ABC) transporter
H7A79_RS10990	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H7A79_RS11035	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H7A79_RS11040	COG1115	amino acid carrier protein
H7A79_RS11055	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H7A79_RS11070	COG0484	heat shock protein binding
H7A79_RS11100	COG1519	Transferase
H7A79_RS11110	COG0412	Dienelactone hydrolase
H7A79_RS11115	COG5487	UPF0391 membrane protein
H7A79_RS11140	COG0729	surface antigen
H7A79_RS11155	COG3676	manually curated
H7A79_RS11165	COG3909	cytochrome
H7A79_RS11170	COG4221	oxidoreductase activity
H7A79_RS11185	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H7A79_RS11205	COG1611	Belongs to the LOG family
H7A79_RS11240	COG1739	Uncharacterized protein family UPF0029
H7A79_RS11265	COG3676	manually curated
H7A79_RS11280	COG0210	DNA helicase
H7A79_RS11300	COG1125	glycine betaine transport
H7A79_RS11300	COG0517	IMP dehydrogenase activity
H7A79_RS11305	COG1174	glycine betaine transport
H7A79_RS11335	COG0405	Gamma-glutamyltransferase
H7A79_RS11340	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
H7A79_RS11365	COG0142	geranyltranstransferase activity
H7A79_RS11375	COG3676	manually curated
H7A79_RS11440	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H7A79_RS11455	COG2837	iron assimilation
H7A79_RS11470	COG0672	)-iron permease
H7A79_RS11525	COG2369	cell adhesion
H7A79_RS11530	COG2954	triphosphatase activity
H7A79_RS11535	COG1981	membrane
H7A79_RS11550	COG0387	Pfam Sodium calcium exchanger
H7A79_RS11555	COG3135	benzoate transporter
H7A79_RS11565	COG3676	manually curated
H7A79_RS11580	COG1199	ATP-dependent helicase activity
H7A79_RS11590	COG3676	manually curated
H7A79_RS11595	COG3676	manually curated
H7A79_RS11615	COG3676	manually curated
H7A79_RS11665	COG0859	PFAM glycosyl transferase family 9
H7A79_RS11670	COG1335	isochorismatase
H7A79_RS11715	COG3676	manually curated
H7A79_RS11745	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H7A79_RS11775	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H7A79_RS11830	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H7A79_RS11840	COG1028	Short-chain dehydrogenase reductase Sdr
H7A79_RS11845	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H7A79_RS11880	COG1555	photosystem II stabilization
H7A79_RS11950	COG0739	heme binding
H7A79_RS11960	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H7A79_RS12025	COG0531	amino acid
H7A79_RS12030	COG1982	Orn Lys Arg decarboxylase major
H7A79_RS12040	COG3676	manually curated
H7A79_RS12110	COG1546	Belongs to the CinA family
H7A79_RS12115	COG1752	Esterase of the alpha-beta hydrolase superfamily
H7A79_RS12135	COG4608	Belongs to the ABC transporter superfamily
H7A79_RS12145	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H7A79_RS12150	COG0601	transmembrane transport
H7A79_RS12175	COG1649	PFAM Uncharacterised BCR, COG1649
H7A79_RS12175	COG0726	polysaccharide deacetylase
H7A79_RS12180	COG1215	transferase activity, transferring glycosyl groups
H7A79_RS12275	COG1393	Belongs to the ArsC family
H7A79_RS12305	COG4535	Mg2 and Co2 transporter CorC
H7A79_RS12325	COG1215	transferase activity, transferring glycosyl groups
H7A79_RS12350	COG1733	regulation of RNA biosynthetic process
H7A79_RS12355	COG4224	UPF0291 protein
H7A79_RS12370	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H7A79_RS12395	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H7A79_RS12425	COG1595	DNA-templated transcription, initiation
H7A79_RS12445	COG0822	iron-sulfur transferase activity
H7A79_RS12465	COG1304	FMN binding
H7A79_RS12470	COG1629	transport
H7A79_RS12470	COG4771	TonB-dependent receptor
H7A79_RS12480	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H7A79_RS12485	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
H7A79_RS12495	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H7A79_RS12500	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H7A79_RS12505	COG0583	DNA-binding transcription factor activity
H7A79_RS12520	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
H7A79_RS12525	COG2967	ApaG domain
H7A79_RS12530	COG1115	amino acid carrier protein
H7A79_RS12535	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
H7A79_RS12590	COG1555	photosystem II stabilization
H7A79_RS12650	COG2733	membrane
H7A79_RS12655	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H7A79_RS12675	COG1793	dna ligase
H7A79_RS12680	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H7A79_RS12710	COG0012	GTP binding
H7A79_RS12720	COG0583	DNA-binding transcription factor activity
H7A79_RS12750	COG2814	Major facilitator Superfamily
H7A79_RS12780	COG1619	proteins homologs of microcin C7 resistance protein MccF
H7A79_RS12800	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H7A79_RS12805	COG2011	ABC-type metal ion transport system permease component
H7A79_RS12810	COG1464	Belongs to the NlpA lipoprotein family
H7A79_RS12815	COG2801	Transposase and inactivated derivatives
H7A79_RS12850	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H7A79_RS12870	COG0512	Glutamine amidotransferase of anthranilate synthase
H7A79_RS12880	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H7A79_RS12890	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
H7A79_RS12915	COG1238	metal cluster binding
H7A79_RS12940	COG4120	Belongs to the binding-protein-dependent transport system permease family
H7A79_RS12945	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
H7A79_RS13015	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H7A79_RS13055	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
H7A79_RS13075	COG1956	GAF domain-containing protein
H7A79_RS13090	COG0739	heme binding
H7A79_RS13110	COG1609	Transcriptional regulator
H7A79_RS13150	COG1929	Belongs to the glycerate kinase type-1 family
H7A79_RS13155	COG0513	Belongs to the DEAD box helicase family
H7A79_RS13160	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
H7A79_RS13185	COG3676	manually curated
H7A79_RS13195	COG0312	modulator of DNA gyrase
H7A79_RS13225	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H7A79_RS13240	COG1120	ATPase activity
H7A79_RS13315	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
H7A79_RS13380	COG0201	protein transport
H7A79_RS13390	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H7A79_RS13455	COG2801	Transposase and inactivated derivatives
H7A79_RS13460	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
H7A79_RS13470	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H7A79_RS13485	COG1575	Belongs to the MenA family. Type 1 subfamily
H7A79_RS13505	COG0723	plastoquinol--plastocyanin reductase activity
H7A79_RS13510	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H7A79_RS13515	COG2857	Cytochrome c1
H7A79_RS13525	COG1757	Na H antiporter
H7A79_RS13535	COG0501	Belongs to the peptidase M48B family
H7A79_RS13555	COG2239	Acts as a magnesium transporter
H7A79_RS13560	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H7A79_RS13585	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
H7A79_RS13590	COG1984	allophanate hydrolase subunit 2
H7A79_RS13600	COG1914	H( )-stimulated, divalent metal cation uptake system
H7A79_RS13610	COG0121	glutamine amidotransferase
H7A79_RS13615	COG3676	manually curated
H7A79_RS13625	COG0471	metal ion transport
H7A79_RS13645	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
H7A79_RS13645	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
H7A79_RS13685	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H7A79_RS13685	COG3453	Protein conserved in bacteria
H7A79_RS13695	COG3278	Belongs to the heme-copper respiratory oxidase family
H7A79_RS13710	COG2010	Cytochrome c
H7A79_RS13760	COG0433	COG0433 Predicted ATPase
H7A79_RS13770	COG3676	manually curated
H7A79_RS13845	COG2369	cell adhesion
H7A79_RS13860	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
H7A79_RS13930	COG3676	manually curated
H7A79_RS13935	COG3676	manually curated
H7A79_RS13980	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H7A79_RS13990	COG0308	aminopeptidase N
H7A79_RS14005	COG1192	Involved in chromosome partitioning
H7A79_RS14110	COG3392	D12 class N6 adenine-specific DNA methyltransferase
H7A79_RS14120	COG0625	glutathione transferase activity
H7A79_RS14125	COG2969	positive regulation of protein catabolic process
H7A79_RS14140	COG0268	Binds directly to 16S ribosomal RNA
H7A79_RS14160	COG3676	manually curated
H7A79_RS14180	COG2354	Protein conserved in bacteria
H7A79_RS14195	COG0765	amino acid transport
H7A79_RS14205	COG0312	modulator of DNA gyrase
H7A79_RS14235	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H7A79_RS14245	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H7A79_RS14255	COG0741	lytic transglycosylase activity
H7A79_RS14260	COG2186	Transcriptional regulator
H7A79_RS14265	COG0247	lactate metabolic process
H7A79_RS14275	COG1139	Iron-sulfur cluster binding protein
H7A79_RS14280	COG1620	l-lactate permease
H7A79_RS14285	COG3279	Response regulator of the LytR AlgR family
H7A79_RS14290	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H7A79_RS14295	COG0824	Thioesterase
H7A79_RS14315	COG2056	Na+-H+ antiporter family
H7A79_RS14330	COG2211	Major facilitator Superfamily
H7A79_RS14340	COG3676	manually curated
H7A79_RS14355	COG1278	Cold shock
H7A79_RS14380	COG3676	manually curated
H7A79_RS14385	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H7A79_RS14395	COG0196	riboflavin kinase activity
H7A79_RS14415	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
H7A79_RS14425	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
H7A79_RS14430	COG1137	ATPase activity
H7A79_RS14435	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
H7A79_RS14500	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
H7A79_RS14510	COG0142	geranyltranstransferase activity
H7A79_RS14530	COG0859	PFAM glycosyl transferase family 9
H7A79_RS14540	COG3909	cytochrome