locus-tag	class	description
H4O27_RS00020	COG0753	catalase activity
H4O27_RS00030	COG0859	PFAM glycosyl transferase family 9
H4O27_RS00040	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H4O27_RS00050	COG1560	Kdo2-lipid A biosynthetic process
H4O27_RS00060	COG0287	Prephenate dehydrogenase
H4O27_RS00075	COG1959	2 iron, 2 sulfur cluster binding
H4O27_RS00105	COG3278	Belongs to the heme-copper respiratory oxidase family
H4O27_RS00120	COG2010	Cytochrome c
H4O27_RS00130	COG0720	synthase
H4O27_RS00145	COG1620	l-lactate permease
H4O27_RS00155	COG2801	Transposase and inactivated derivatives
H4O27_RS00180	COG0012	GTP binding
H4O27_RS00225	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H4O27_RS00300	COG0142	geranyltranstransferase activity
H4O27_RS00315	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
H4O27_RS00370	COG1555	photosystem II stabilization
H4O27_RS00385	COG0469	pyruvate kinase activity
H4O27_RS00450	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H4O27_RS00450	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H4O27_RS00460	COG5000	phosphorelay sensor kinase activity
H4O27_RS00465	COG2204	response regulator
H4O27_RS00470	COG0758	DNA mediated transformation
H4O27_RS00485	COG1476	TRANSCRIPTIONal
H4O27_RS00490	COG0742	ribosomal rna small subunit methyltransferase
H4O27_RS00495	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H4O27_RS00575	COG2885	chlorophyll binding
H4O27_RS00620	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
H4O27_RS00630	COG0732	type I restriction modification DNA specificity domain
H4O27_RS00635	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
H4O27_RS00740	COG0201	protein transport
H4O27_RS00750	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H4O27_RS00790	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H4O27_RS00825	COG2119	membrane
H4O27_RS00890	COG0356	it plays a direct role in the translocation of protons across the membrane
H4O27_RS00970	COG2807	transmembrane transport
H4O27_RS00980	COG1970	mechanosensitive ion channel activity
H4O27_RS00995	COG0791	NLP P60 protein
H4O27_RS01005	COG1346	cytolysis
H4O27_RS01030	COG2814	Major facilitator Superfamily
H4O27_RS01065	COG1609	Transcriptional regulator
H4O27_RS01075	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H4O27_RS01075	COG0512	Glutamine amidotransferase of anthranilate synthase
H4O27_RS01110	COG0456	acetyltransferase
H4O27_RS01115	COG1214	PFAM Peptidase M22, glycoprotease
H4O27_RS01125	COG3279	Response regulator of the LytR AlgR family
H4O27_RS01130	COG0406	alpha-ribazole phosphatase activity
H4O27_RS01165	COG0489	protein tyrosine kinase activity
H4O27_RS01170	COG5487	UPF0391 membrane protein
H4O27_RS01180	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
H4O27_RS01185	COG1137	ATPase activity
H4O27_RS01190	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
H4O27_RS01275	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
H4O27_RS01290	COG0312	modulator of DNA gyrase
H4O27_RS01305	COG0714	Associated with various cellular activities
H4O27_RS01330	COG2056	Na+-H+ antiporter family
H4O27_RS01345	COG1902	pentaerythritol trinitrate reductase activity
H4O27_RS01390	COG2239	Acts as a magnesium transporter
H4O27_RS01395	COG0583	DNA-binding transcription factor activity
H4O27_RS01405	COG0723	plastoquinol--plastocyanin reductase activity
H4O27_RS01410	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H4O27_RS01415	COG2857	Cytochrome c1
H4O27_RS01420	COG0625	glutathione transferase activity
H4O27_RS01425	COG2969	positive regulation of protein catabolic process
H4O27_RS01470	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H4O27_RS01475	COG0315	cyclic pyranopterin monophosphate synthase activity
H4O27_RS01535	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H4O27_RS01590	COG2801	Transposase and inactivated derivatives
H4O27_RS01595	COG2801	Transposase and inactivated derivatives
H4O27_RS01700	COG2081	HI0933 family
H4O27_RS01705	COG0814	amino acid
H4O27_RS01715	COG0628	permease
H4O27_RS01720	COG0339	signal peptide processing
H4O27_RS01725	COG3949	Membrane
H4O27_RS01750	COG0210	DNA helicase
H4O27_RS01755	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H4O27_RS01765	COG2878	Part of a membrane complex involved in electron transport
H4O27_RS01775	COG4604	ABC transporter, ATP-binding protein
H4O27_RS01780	COG4605	iron ion homeostasis
H4O27_RS01785	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
H4O27_RS01790	COG0500	methyltransferase
H4O27_RS01795	COG2830	Protein of unknown function (DUF452)
H4O27_RS01805	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H4O27_RS01810	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H4O27_RS01825	COG4607	ABC-type enterochelin transport system periplasmic component
H4O27_RS01895	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
H4O27_RS01925	COG0196	riboflavin kinase activity
H4O27_RS01945	COG2885	chlorophyll binding
H4O27_RS01955	COG0739	heme binding
H4O27_RS01980	COG0613	PHP domain protein
H4O27_RS02000	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H4O27_RS02005	COG0640	Transcriptional regulator
H4O27_RS02065	COG2610	gluconate transmembrane transporter activity
H4O27_RS02070	COG3265	gluconokinase activity
H4O27_RS02095	COG2350	Protein conserved in bacteria
H4O27_RS02145	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H4O27_RS02150	COG2999	glutathione oxidoreductase activity
H4O27_RS02170	COG0513	Belongs to the DEAD box helicase family
H4O27_RS02180	COG2175	clavaminate synthase activity
H4O27_RS02200	COG1045	serine acetyltransferase
H4O27_RS02230	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H4O27_RS02250	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H4O27_RS02260	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
H4O27_RS02270	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H4O27_RS02280	COG1733	regulation of RNA biosynthetic process
H4O27_RS02285	COG2910	NAD(P)H-binding
H4O27_RS02340	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
H4O27_RS02345	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H4O27_RS02350	COG1280	lysine exporter protein (LysE YggA)
H4O27_RS02360	COG2801	Transposase and inactivated derivatives
H4O27_RS02365	COG0121	glutamine amidotransferase
H4O27_RS02420	COG1333	cytochrome c biogenesis protein
H4O27_RS02425	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H4O27_RS02440	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H4O27_RS02445	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H4O27_RS02505	COG1518	maintenance of DNA repeat elements
H4O27_RS02510	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
H4O27_RS02530	COG0477	Major facilitator Superfamily
H4O27_RS02545	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H4O27_RS02550	COG2423	ornithine cyclodeaminase activity
H4O27_RS02570	COG1741	Belongs to the pirin family
H4O27_RS02605	COG0583	DNA-binding transcription factor activity
H4O27_RS02615	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H4O27_RS02625	COG4221	oxidoreductase activity
H4O27_RS02645	COG0583	DNA-binding transcription factor activity
H4O27_RS02650	COG0475	glutathione-regulated potassium exporter activity
H4O27_RS02650	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H4O27_RS02660	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H4O27_RS02670	COG1028	Short-chain dehydrogenase reductase Sdr
H4O27_RS02680	COG4224	UPF0291 protein
H4O27_RS02685	COG1733	regulation of RNA biosynthetic process
H4O27_RS02690	COG2153	protein acetylation
H4O27_RS02695	COG1028	Short-chain dehydrogenase reductase Sdr
H4O27_RS02700	COG0435	Glutathione S-transferase
H4O27_RS02725	COG2918	glutathione biosynthetic process
H4O27_RS02745	COG2358	TRAP transporter, solute receptor (TAXI family
H4O27_RS02750	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H4O27_RS02755	COG1966	Carbon starvation protein
H4O27_RS02785	COG0697	spore germination
H4O27_RS02810	COG2252	PERMEase
H4O27_RS02830	COG1280	lysine exporter protein (LysE YggA)
H4O27_RS02845	COG2828	Protein conserved in bacteria
H4O27_RS02850	COG0009	L-threonylcarbamoyladenylate synthase
H4O27_RS02855	COG1794	racemase activity, acting on amino acids and derivatives
H4O27_RS02860	COG1994	Peptidase M50
H4O27_RS02870	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H4O27_RS02875	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H4O27_RS02880	COG0583	DNA-binding transcription factor activity
H4O27_RS02890	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
H4O27_RS02895	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
H4O27_RS02900	COG2967	ApaG domain
H4O27_RS02905	COG1115	amino acid carrier protein
H4O27_RS02945	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
H4O27_RS02945	COG0644	oxidoreductase
H4O27_RS02950	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
H4O27_RS02960	COG0187	DNA topoisomerase II activity
H4O27_RS02980	COG0433	COG0433 Predicted ATPase
H4O27_RS02990	COG2814	Major facilitator Superfamily
H4O27_RS03000	COG2991	Protein conserved in bacteria
H4O27_RS03005	COG1477	protein flavinylation
H4O27_RS03020	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H4O27_RS03045	COG0656	L-ascorbic acid biosynthetic process
H4O27_RS03060	COG1999	signal sequence binding
H4O27_RS03070	COG3064	Membrane
H4O27_RS03070	COG3525	Glycosyl hydrolase, family 20, catalytic domain
H4O27_RS03070	COG3583	domain protein
H4O27_RS03075	COG0028	Belongs to the TPP enzyme family
H4O27_RS03115	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
H4O27_RS03125	COG1477	protein flavinylation
H4O27_RS03135	COG1215	transferase activity, transferring glycosyl groups
H4O27_RS03140	COG0726	polysaccharide deacetylase
H4O27_RS03140	COG1649	PFAM Uncharacterised BCR, COG1649
H4O27_RS03155	COG0733	neurotransmitter:sodium symporter activity
H4O27_RS03170	COG0582	viral genome integration into host DNA
H4O27_RS03190	COG0471	metal ion transport
H4O27_RS03195	COG2995	paraquat-inducible protein a
H4O27_RS03200	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H4O27_RS03200	COG3008	intermembrane lipid transfer
H4O27_RS03210	COG2801	Transposase and inactivated derivatives
H4O27_RS03220	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H4O27_RS03240	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H4O27_RS03250	COG0281	malic enzyme
H4O27_RS03250	COG0280	phosphate acetyltransferase
H4O27_RS03260	COG3909	cytochrome
H4O27_RS03265	COG4221	oxidoreductase activity
H4O27_RS03275	COG0523	cobalamin synthesis protein
H4O27_RS03285	COG4174	ABC transporter (Permease)
H4O27_RS03290	COG4239	(ABC) transporter, permease
H4O27_RS03295	COG0318	PFAM AMP-dependent synthetase and ligase
H4O27_RS03300	COG4172	Belongs to the ABC transporter superfamily
H4O27_RS03310	COG2733	membrane
H4O27_RS03345	COG0084	hydrolase, TatD family'
H4O27_RS03350	COG1652	LysM domain
H4O27_RS03360	COG0730	response to heat
H4O27_RS03365	COG1183	phosphatidylcholine synthase activity
H4O27_RS03405	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
H4O27_RS03405	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
H4O27_RS03480	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H4O27_RS03510	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H4O27_RS03515	COG0667	Aldo Keto reductase
H4O27_RS03550	COG2159	amidohydrolase
H4O27_RS03565	COG1053	succinate dehydrogenase
H4O27_RS03580	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H4O27_RS03585	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H4O27_RS03590	COG1120	ATPase activity
H4O27_RS03595	COG1082	Xylose isomerase domain protein TIM barrel
H4O27_RS03595	COG3185	4-Hydroxyphenylpyruvate dioxygenase
H4O27_RS03605	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H4O27_RS03610	COG2828	Protein conserved in bacteria
H4O27_RS03615	COG0583	DNA-binding transcription factor activity
H4O27_RS03630	COG0778	Nitroreductase
H4O27_RS03635	COG0583	DNA-binding transcription factor activity
H4O27_RS03645	COG1846	Transcriptional regulator
H4O27_RS03650	COG1902	pentaerythritol trinitrate reductase activity
H4O27_RS03655	COG2267	carboxylic ester hydrolase activity
H4O27_RS03660	COG4977	sequence-specific DNA binding
H4O27_RS03670	COG0569	domain protein
H4O27_RS03680	COG3118	belongs to the thioredoxin family
H4O27_RS03700	COG2070	2-Nitropropane dioxygenase
H4O27_RS03705	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
H4O27_RS03725	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H4O27_RS03740	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H4O27_RS03780	COG3647	Membrane
H4O27_RS03795	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
H4O27_RS03795	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H4O27_RS03840	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
H4O27_RS03850	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H4O27_RS03885	COG1555	photosystem II stabilization
H4O27_RS03910	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
H4O27_RS03965	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
H4O27_RS03970	COG0859	PFAM glycosyl transferase family 9
H4O27_RS03990	COG0277	FAD linked oxidase domain protein
H4O27_RS04015	COG2070	2-Nitropropane dioxygenase
H4O27_RS04035	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H4O27_RS04060	COG2233	PERMEase
H4O27_RS04115	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H4O27_RS04130	COG0725	ABC transporter, periplasmic molybdate-binding protein
H4O27_RS04135	COG4149	molybdate abc transporter
H4O27_RS04140	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
H4O27_RS04150	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H4O27_RS04160	COG0681	Belongs to the peptidase S26 family
H4O27_RS04170	COG2801	Transposase and inactivated derivatives
H4O27_RS04210	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H4O27_RS04215	COG2217	Heavy metal translocating P-type atpase
H4O27_RS04230	COG0175	sulfate reduction
H4O27_RS04250	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
H4O27_RS04320	COG0277	FAD linked oxidase domain protein
H4O27_RS04340	COG1523	belongs to the glycosyl hydrolase 13 family
H4O27_RS04355	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H4O27_RS04370	COG0318	PFAM AMP-dependent synthetase and ligase
H4O27_RS04400	COG0497	DNA recombination
H4O27_RS04420	COG1929	Belongs to the glycerate kinase type-1 family
H4O27_RS04425	COG2610	gluconate transmembrane transporter activity
H4O27_RS04430	COG3835	regulator
H4O27_RS04445	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H4O27_RS04455	COG1309	transcriptional regulator
H4O27_RS04485	COG3210	domain, Protein
H4O27_RS04580	COG0488	(ABC) transporter
H4O27_RS04585	COG0346	lactoylglutathione lyase activity
H4O27_RS04590	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H4O27_RS04600	COG1177	transmembrane transport
H4O27_RS04605	COG1176	ABC-type spermidine putrescine transport system, permease component I
H4O27_RS04610	COG3842	ATPase activity
H4O27_RS04650	COG0793	Belongs to the peptidase S41A family
H4O27_RS04660	COG3045	CreA protein
H4O27_RS04675	COG3753	Protein conserved in bacteria
H4O27_RS04680	COG1238	metal cluster binding
H4O27_RS04685	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H4O27_RS04725	COG2813	Specifically methylates the guanine in position
H4O27_RS04725	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H4O27_RS04730	COG1607	acyl-coa hydrolase
H4O27_RS04735	COG0598	Magnesium transport protein CorA
H4O27_RS04740	COG1217	gtp-binding protein TYPA
H4O27_RS04755	COG0385	Bile acid
H4O27_RS04770	COG0590	tRNA wobble adenosine to inosine editing
H4O27_RS04790	COG0583	DNA-binding transcription factor activity
H4O27_RS04805	COG0628	permease
H4O27_RS04815	COG0521	Mo-molybdopterin cofactor biosynthetic process
H4O27_RS04825	COG0488	(ABC) transporter
H4O27_RS04840	COG0492	ferredoxin-NADP+ reductase activity
H4O27_RS04855	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H4O27_RS04875	COG2841	Protein conserved in bacteria
H4O27_RS04880	COG1074	ATP-dependent DNA helicase activity
H4O27_RS04885	COG2837	iron assimilation
H4O27_RS04890	COG1408	metallophosphoesterase
H4O27_RS04895	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
H4O27_RS04910	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
H4O27_RS04930	COG0617	tRNA 3'-terminal CCA addition
H4O27_RS04955	COG0513	Belongs to the DEAD box helicase family
H4O27_RS04960	COG1388	LysM domain
H4O27_RS04960	COG0741	lytic transglycosylase activity
H4O27_RS04980	COG0678	peroxiredoxin activity
H4O27_RS04980	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H4O27_RS05000	COG2801	Transposase and inactivated derivatives
H4O27_RS05015	COG1012	belongs to the aldehyde dehydrogenase family
H4O27_RS05040	COG4774	siderophore transport
H4O27_RS05070	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
H4O27_RS05075	COG0105	UTP biosynthetic process
H4O27_RS05090	COG1426	Protein conserved in bacteria
H4O27_RS05100	COG0564	pseudouridine synthase activity
H4O27_RS05125	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
H4O27_RS05135	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H4O27_RS05145	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H4O27_RS05165	COG1114	Component of the transport system for branched-chain amino acids
H4O27_RS05185	COG1704	LemA family
H4O27_RS05220	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
H4O27_RS05265	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H4O27_RS05270	COG0765	amino acid transport
H4O27_RS05275	COG1126	abc transporter atp-binding protein
H4O27_RS05280	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
H4O27_RS05290	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H4O27_RS05320	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H4O27_RS05340	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H4O27_RS05345	COG0842	Transport permease protein
H4O27_RS05345	COG1129	ABC transporter
H4O27_RS05350	COG0842	Transport permease protein
H4O27_RS05360	COG1538	Outer membrane efflux protein
H4O27_RS05365	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H4O27_RS05375	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H4O27_RS05380	COG0633	Ferredoxin
H4O27_RS05385	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H4O27_RS05430	COG1139	Iron-sulfur cluster binding protein
H4O27_RS05440	COG0247	lactate metabolic process
H4O27_RS05445	COG0477	Major facilitator Superfamily
H4O27_RS05450	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H4O27_RS05455	COG0791	NLP P60 protein
H4O27_RS05460	COG0408	coproporphyrinogen oxidase activity
H4O27_RS05500	COG0251	oxidation-reduction process
H4O27_RS05505	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H4O27_RS05510	COG0697	spore germination
H4O27_RS05640	COG3210	domain, Protein
H4O27_RS05645	COG2831	hemolysin activation secretion protein
H4O27_RS05655	COG3676	manually curated
H4O27_RS05675	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
H4O27_RS05680	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H4O27_RS05685	COG0288	reversible hydration of carbon dioxide
H4O27_RS05700	COG4208	sulfate ABC transporter
H4O27_RS05720	COG0512	Glutamine amidotransferase of anthranilate synthase
H4O27_RS05730	COG3568	Endonuclease Exonuclease Phosphatase
H4O27_RS05735	COG0557	exoribonuclease II activity
H4O27_RS05765	COG0463	Glycosyl transferase, family 2
H4O27_RS05785	COG2801	Transposase and inactivated derivatives
H4O27_RS05795	COG1393	Belongs to the ArsC family
H4O27_RS05825	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H4O27_RS05835	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
H4O27_RS05860	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H4O27_RS05865	COG3318	Belongs to the UPF0149 family
H4O27_RS05865	COG3012	SEC-C Motif Domain Protein
H4O27_RS05895	COG2866	Carboxypeptidase
H4O27_RS05920	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
H4O27_RS05930	COG0456	acetyltransferase
H4O27_RS05940	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
H4O27_RS05960	COG1028	Short-chain dehydrogenase reductase Sdr
H4O27_RS05970	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
H4O27_RS05975	COG0508	dehydrogenase complex catalyzes the overall conversion of
H4O27_RS05980	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H4O27_RS05990	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H4O27_RS06010	COG0626	cystathionine gamma-synthase activity
H4O27_RS06020	COG1562	ergosterol biosynthetic process
H4O27_RS06030	COG1027	Aspartate ammonia-lyase
H4O27_RS06035	COG0436	Aminotransferase
H4O27_RS06060	COG4178	(ABC) transporter
H4O27_RS06065	COG4774	siderophore transport
H4O27_RS06110	COG0741	lytic transglycosylase activity
H4O27_RS06155	COG0681	Belongs to the peptidase S26 family
H4O27_RS06340	COG4453	Protein conserved in bacteria
H4O27_RS06395	COG2831	hemolysin activation secretion protein
H4O27_RS06400	COG3210	domain, Protein
H4O27_RS06465	COG1278	Cold shock
H4O27_RS06490	COG2894	cell division
H4O27_RS06520	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H4O27_RS06535	COG0307	riboflavin synthase, alpha
H4O27_RS06545	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
H4O27_RS06605	COG0488	(ABC) transporter
H4O27_RS06625	COG1294	oxidase, subunit
H4O27_RS06635	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
H4O27_RS06640	COG4988	ABC transporter
H4O27_RS06670	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
H4O27_RS06680	COG3676	manually curated
H4O27_RS06690	COG2831	hemolysin activation secretion protein
H4O27_RS06695	COG3210	domain, Protein
H4O27_RS06710	COG3210	domain, Protein
H4O27_RS06780	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
H4O27_RS06785	COG0625	glutathione transferase activity
H4O27_RS06795	COG5005	Phage virion morphogenesis
H4O27_RS06800	COG2369	cell adhesion
H4O27_RS06805	COG4383	Mu-like prophage protein gp29
H4O27_RS06810	COG4373	Mu-like prophage FluMu protein gp28
H4O27_RS06830	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H4O27_RS07125	COG2801	Transposase and inactivated derivatives
H4O27_RS07130	COG2095	MarC family integral membrane protein
H4O27_RS07135	COG0772	Belongs to the SEDS family
H4O27_RS07140	COG0768	penicillin binding
H4O27_RS07145	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
H4O27_RS07150	COG1792	Involved in formation and maintenance of cell shape
H4O27_RS07155	COG1077	Cell shape determining protein MreB Mrl
H4O27_RS07195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H4O27_RS07225	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H4O27_RS07225	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H4O27_RS07230	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H4O27_RS07325	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H4O27_RS07330	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
H4O27_RS07350	COG2814	Major facilitator Superfamily
H4O27_RS07355	COG2608	mercury ion transmembrane transporter activity
H4O27_RS07360	COG2217	Heavy metal translocating P-type atpase
H4O27_RS07375	COG0006	proline dipeptidase activity
H4O27_RS07405	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H4O27_RS07435	COG2814	Major facilitator Superfamily
H4O27_RS07440	COG1196	nuclear chromosome segregation
H4O27_RS07440	COG0741	lytic transglycosylase activity
H4O27_RS07440	COG0739	heme binding
H4O27_RS07445	COG0248	Ppx GppA phosphatase
H4O27_RS07455	COG0667	Aldo Keto reductase
H4O27_RS07465	COG1280	lysine exporter protein (LysE YggA)
H4O27_RS07475	COG0330	HflC and HflK could
H4O27_RS07515	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H4O27_RS07520	COG1686	Belongs to the peptidase S11 family
H4O27_RS07525	COG1943	Transposase
H4O27_RS07550	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H4O27_RS07555	COG0305	Participates in initiation and elongation during chromosome replication
H4O27_RS07680	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H4O27_RS07685	COG0303	'Molybdopterin
H4O27_RS07705	COG3850	Histidine kinase
H4O27_RS07710	COG2197	response regulator
H4O27_RS07725	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
H4O27_RS07730	COG1882	Formate acetyltransferase
H4O27_RS07755	COG0822	iron-sulfur transferase activity
H4O27_RS07760	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H4O27_RS07790	COG0471	metal ion transport
H4O27_RS07795	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H4O27_RS07800	COG2321	neutral zinc metallopeptidase
H4O27_RS07805	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
H4O27_RS07820	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H4O27_RS07870	COG1187	pseudouridine synthase activity
H4O27_RS07880	COG2801	Transposase and inactivated derivatives
H4O27_RS07890	COG0733	neurotransmitter:sodium symporter activity
H4O27_RS07920	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H4O27_RS07985	COG0789	Transcriptional regulator
H4O27_RS08025	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H4O27_RS08035	COG0508	dehydrogenase complex catalyzes the overall conversion of
H4O27_RS08040	COG0567	Dehydrogenase, E1 component
H4O27_RS08050	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
H4O27_RS08055	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H4O27_RS08060	COG1053	succinate dehydrogenase
H4O27_RS08175	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H4O27_RS08185	COG0076	glutamate decarboxylase activity
H4O27_RS08190	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H4O27_RS08210	COG1278	Cold shock
H4O27_RS08235	COG0798	PFAM Bile acid sodium symporter
H4O27_RS08255	COG0438	transferase activity, transferring glycosyl groups
H4O27_RS08260	COG1132	(ABC) transporter
H4O27_RS08280	COG1187	pseudouridine synthase activity
H4O27_RS08285	COG1064	alcohol dehydrogenase
H4O27_RS08300	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H4O27_RS08305	COG2951	lytic endotransglycosylase activity
H4O27_RS08350	COG5002	protein histidine kinase activity
H4O27_RS08355	COG1764	response to oxidative stress
H4O27_RS08360	COG2193	ferroxidase activity
H4O27_RS08370	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
H4O27_RS08370	COG3264	Mechanosensitive ion channel
H4O27_RS08375	COG0494	nUDIX hydrolase
H4O27_RS08395	COG1607	acyl-coa hydrolase
H4O27_RS08400	COG2315	Protein conserved in bacteria
H4O27_RS08420	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
H4O27_RS08430	COG0471	metal ion transport
H4O27_RS08435	COG0569	domain protein
H4O27_RS08450	COG0501	Belongs to the peptidase M48B family
H4O27_RS08455	COG1686	Belongs to the peptidase S11 family
H4O27_RS08475	COG1194	a g-specific adenine glycosylase
H4O27_RS08480	COG0765	amino acid transport
H4O27_RS08485	COG0826	peptidase U32
H4O27_RS08495	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H4O27_RS08500	COG2011	ABC-type metal ion transport system permease component
H4O27_RS08505	COG1464	Belongs to the NlpA lipoprotein family
H4O27_RS08525	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H4O27_RS08530	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
H4O27_RS08560	COG0561	phosphatase activity
H4O27_RS08565	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
H4O27_RS08570	COG1140	nitrate reductase beta subunit
H4O27_RS08575	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
H4O27_RS08580	COG2181	nitrate reductase activity
H4O27_RS08590	COG2223	nitrite transmembrane transporter activity
H4O27_RS08595	COG3850	Histidine kinase
H4O27_RS08600	COG2197	response regulator
H4O27_RS08605	COG0741	lytic transglycosylase activity
H4O27_RS08625	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H4O27_RS08635	COG1610	YqeY-like protein
H4O27_RS08655	COG0702	epimerase
H4O27_RS08660	COG1702	phosphate starvation-inducible protein PhoH
H4O27_RS08665	COG3720	iron ion transport
H4O27_RS08670	COG1629	transport
H4O27_RS08670	COG4771	TonB-dependent receptor
H4O27_RS08675	COG4558	Periplasmic binding protein
H4O27_RS08685	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
H4O27_RS08710	COG0560	Phosphoserine phosphatase
H4O27_RS08715	COG1757	Na H antiporter
H4O27_RS08720	COG0738	Major facilitator superfamily
H4O27_RS08725	COG1238	metal cluster binding
H4O27_RS08730	COG1448	Aminotransferase
H4O27_RS08745	COG2833	Protein of unknown function (DUF455)
H4O27_RS08765	COG0857	belongs to the CobB CobQ family
H4O27_RS08765	COG0280	phosphate acetyltransferase
H4O27_RS08790	COG0084	hydrolase, TatD family'
H4O27_RS08795	COG0252	asparaginase activity
H4O27_RS08805	COG0586	Pfam SNARE associated Golgi protein
H4O27_RS08820	COG1448	Aminotransferase
H4O27_RS08835	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
H4O27_RS08855	COG1115	amino acid carrier protein
H4O27_RS08860	COG1272	protein, Hemolysin III
H4O27_RS08895	COG0625	glutathione transferase activity
H4O27_RS08905	COG2431	L-lysine efflux transmembrane transporter activity
H4O27_RS08915	COG1765	OsmC-like protein
H4O27_RS08920	COG0351	phosphomethylpyrimidine kinase
H4O27_RS08925	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
H4O27_RS08940	COG1012	belongs to the aldehyde dehydrogenase family
H4O27_RS08970	COG2801	Transposase and inactivated derivatives
H4O27_RS09030	COG0312	modulator of DNA gyrase
H4O27_RS09035	COG0438	transferase activity, transferring glycosyl groups
H4O27_RS09045	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
H4O27_RS09060	COG0285	dihydrofolate synthase activity
H4O27_RS09100	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H4O27_RS09115	COG3275	phosphorelay sensor kinase activity
H4O27_RS09120	COG1561	YicC-like family, N-terminal region
H4O27_RS09140	COG0527	aspartate kinase activity
H4O27_RS09195	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H4O27_RS09225	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
H4O27_RS09235	COG0800	Aldolase
H4O27_RS09305	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H4O27_RS09435	COG4942	peptidase
H4O27_RS09450	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H4O27_RS09465	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H4O27_RS09490	COG3615	Tellurite resistance protein tehB
H4O27_RS09490	COG0500	methyltransferase
H4O27_RS09505	COG1619	proteins homologs of microcin C7 resistance protein MccF
H4O27_RS09515	COG2801	Transposase and inactivated derivatives
H4O27_RS09525	COG0195	Participates in both transcription termination and antitermination
H4O27_RS09540	COG0778	Nitroreductase
H4O27_RS09550	COG3423	Transcriptional regulator
H4O27_RS09740	COG2369	cell adhesion
H4O27_RS09850	COG3392	D12 class N6 adenine-specific DNA methyltransferase
H4O27_RS09855	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H4O27_RS09860	COG2814	Major facilitator Superfamily
H4O27_RS09870	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H4O27_RS09875	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H4O27_RS09880	COG1862	Preprotein translocase
H4O27_RS09885	COG0123	including yeast histone deacetylase and acetoin utilization protein
H4O27_RS09895	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
H4O27_RS09900	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
H4O27_RS09905	COG2116	formate transmembrane transporter activity
H4O27_RS09910	COG2864	formate dehydrogenase
H4O27_RS09915	COG0437	4 iron, 4 sulfur cluster binding
H4O27_RS09920	COG0243	molybdopterin cofactor binding
H4O27_RS09920	COG3383	formate dehydrogenase (NAD+) activity
H4O27_RS09960	COG1538	Outer membrane efflux protein
H4O27_RS09970	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H4O27_RS09985	COG4535	Mg2 and Co2 transporter CorC
H4O27_RS10005	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H4O27_RS10010	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H4O27_RS10015	COG1757	Na H antiporter
H4O27_RS10030	COG2354	Protein conserved in bacteria
H4O27_RS10040	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H4O27_RS10055	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H4O27_RS10070	COG3945	hemerythrin HHE cation binding domain
H4O27_RS10145	COG2818	Glycosylase
H4O27_RS10160	COG1522	sequence-specific DNA binding
H4O27_RS10170	COG2832	Protein of unknown function (DUF454)
H4O27_RS10180	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H4O27_RS10235	COG0805	protein transport
H4O27_RS10250	COG0745	RESPONSE REGULATOR receiver
H4O27_RS10255	COG2205	protein histidine kinase activity
H4O27_RS10295	COG0583	DNA-binding transcription factor activity
H4O27_RS10315	COG3177	Filamentation induced by cAMP protein fic
H4O27_RS10365	COG1733	regulation of RNA biosynthetic process
H4O27_RS10375	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H4O27_RS10380	COG0308	aminopeptidase N
H4O27_RS10385	COG1960	acyl-CoA dehydrogenase activity
H4O27_RS10395	COG2814	Major facilitator Superfamily
H4O27_RS10400	COG0318	PFAM AMP-dependent synthetase and ligase
H4O27_RS10405	COG1012	belongs to the aldehyde dehydrogenase family
H4O27_RS10410	COG1024	Enoyl-CoA hydratase
H4O27_RS10450	COG2801	Transposase and inactivated derivatives
H4O27_RS10475	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H4O27_RS10485	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H4O27_RS10485	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H4O27_RS10500	COG0438	transferase activity, transferring glycosyl groups
H4O27_RS10520	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H4O27_RS10535	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H4O27_RS10540	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H4O27_RS10570	COG0511	ligase activity, forming carbon-carbon bonds
H4O27_RS10575	COG0439	Biotin carboxylase
H4O27_RS10590	COG4166	transmembrane transport
H4O27_RS10610	COG0640	Transcriptional regulator
H4O27_RS10620	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H4O27_RS10630	COG3177	Filamentation induced by cAMP protein fic
H4O27_RS10665	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H4O27_RS10690	COG0488	(ABC) transporter
H4O27_RS10715	COG0802	atpase or kinase
H4O27_RS10725	COG0456	acetyltransferase
H4O27_RS10735	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H4O27_RS10750	COG1530	ribonuclease E activity
H4O27_RS10765	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H4O27_RS10770	COG1555	photosystem II stabilization
H4O27_RS10830	COG1289	transmembrane transporter activity
H4O27_RS10835	COG1131	(ABC) transporter
H4O27_RS10855	COG0297	glycogen (starch) synthase activity
H4O27_RS10865	COG0668	transmembrane transport
H4O27_RS10870	COG0842	Transport permease protein
H4O27_RS10935	COG2962	Rard protein
H4O27_RS10950	COG2837	iron assimilation
H4O27_RS10960	COG0672	)-iron permease
H4O27_RS10980	COG2801	Transposase and inactivated derivatives
H4O27_RS11085	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
H4O27_RS11095	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H4O27_RS11100	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H4O27_RS11105	COG2824	Alkylphosphonate utilization operon protein PhnA
H4O27_RS11135	COG1981	membrane
H4O27_RS11140	COG2954	triphosphatase activity
H4O27_RS11155	COG0612	Peptidase, M16
H4O27_RS11250	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H4O27_RS11260	COG2884	Cell division ATP-binding protein ftsE
H4O27_RS11270	COG1546	Belongs to the CinA family
H4O27_RS11290	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H4O27_RS11295	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
H4O27_RS11300	COG0405	Gamma-glutamyltransferase
H4O27_RS11325	COG0859	PFAM glycosyl transferase family 9
H4O27_RS11340	COG1739	Uncharacterized protein family UPF0029
H4O27_RS11360	COG0514	ATP-dependent DNA helicase (RecQ)
H4O27_RS11365	COG2259	Doxx family
H4O27_RS11380	COG3219	Protein conserved in bacteria
H4O27_RS11385	COG1595	DNA-templated transcription, initiation
H4O27_RS11395	COG1199	ATP-dependent helicase activity
H4O27_RS11420	COG1674	ftsk spoiiie
H4O27_RS11435	COG1040	competence protein
H4O27_RS11440	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H4O27_RS11480	COG1132	(ABC) transporter
H4O27_RS11485	COG1752	Esterase of the alpha-beta hydrolase superfamily
H4O27_RS11525	COG0142	geranyltranstransferase activity
H4O27_RS11540	COG0729	surface antigen
H4O27_RS11550	COG2040	homocysteine
H4O27_RS11570	COG0531	amino acid
H4O27_RS11580	COG0557	exoribonuclease II activity
H4O27_RS11605	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H4O27_RS11625	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
H4O27_RS11640	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
H4O27_RS11645	COG1234	tRNA 3'-trailer cleavage
H4O27_RS11650	COG1034	ATP synthesis coupled electron transport
H4O27_RS11695	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
H4O27_RS11700	COG0415	Belongs to the DNA photolyase family
H4O27_RS11710	COG1519	Transferase
H4O27_RS11740	COG1115	amino acid carrier protein
H4O27_RS11750	COG0583	DNA-binding transcription factor activity
H4O27_RS11825	COG2801	Transposase and inactivated derivatives
H4O27_RS11865	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
H4O27_RS11890	COG2801	Transposase and inactivated derivatives
H4O27_RS11960	COG0708	Exodeoxyribonuclease III
H4O27_RS11985	COG2801	Transposase and inactivated derivatives
H4O27_RS12010	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H4O27_RS12025	COG2860	membrane
H4O27_RS12035	COG0671	phosphoesterase, PA-phosphatase related
H4O27_RS12040	COG1546	Belongs to the CinA family
H4O27_RS12040	COG1058	Belongs to the CinA family
H4O27_RS12065	COG2823	Periplasmic or secreted lipoprotein
H4O27_RS12115	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H4O27_RS12115	COG0616	signal peptide processing
H4O27_RS12120	COG0583	DNA-binding transcription factor activity
H4O27_RS12125	COG2259	Doxx family
H4O27_RS12155	COG0799	negative regulation of ribosome biogenesis
H4O27_RS12165	COG3909	cytochrome
H4O27_RS12175	COG1643	Atp-dependent helicase
H4O27_RS12195	COG1192	Involved in chromosome partitioning
H4O27_RS12235	COG2032	superoxide dismutase activity
H4O27_RS12240	COG3180	Ammonia monooxygenase
H4O27_RS12275	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H4O27_RS12285	COG0824	Thioesterase
H4O27_RS12310	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H4O27_RS12315	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H4O27_RS12325	COG1127	ABC transporter
H4O27_RS12345	COG1530	ribonuclease E activity
H4O27_RS12355	COG0133	tryptophan synthase activity
H4O27_RS12370	COG0385	Bile acid
H4O27_RS12385	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H4O27_RS12385	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H4O27_RS12470	COG0786	glutamate:sodium symporter activity
H4O27_RS12495	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H4O27_RS12500	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H4O27_RS12505	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H4O27_RS12510	COG1956	GAF domain-containing protein
H4O27_RS12520	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H4O27_RS12545	COG1793	dna ligase
H4O27_RS12550	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H4O27_RS12575	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H4O27_RS12585	COG1505	serine-type exopeptidase activity
H4O27_RS12590	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
H4O27_RS12605	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H4O27_RS12630	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H4O27_RS12635	COG1053	succinate dehydrogenase
H4O27_RS12640	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
H4O27_RS12645	COG1984	allophanate hydrolase subunit 2
H4O27_RS12655	COG1914	H( )-stimulated, divalent metal cation uptake system
H4O27_RS12665	COG3691	Protein conserved in bacteria
H4O27_RS12680	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
H4O27_RS12685	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
H4O27_RS12695	COG0483	inositol monophosphate 1-phosphatase activity
H4O27_RS12700	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H4O27_RS12710	COG0297	glycogen (starch) synthase activity
H4O27_RS12710	COG0438	transferase activity, transferring glycosyl groups
H4O27_RS12720	COG1216	Glycosyl transferase, family 2
H4O27_RS12770	COG1028	Short-chain dehydrogenase reductase Sdr
H4O27_RS12785	COG0331	[acyl-carrier-protein] S-malonyltransferase activity