locus-tag	class	description
CYG48_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CYG48_RS00015	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CYG48_RS00020	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CYG48_RS00030	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CYG48_RS00035	COG1420	regulation of RNA biosynthetic process
CYG48_RS00040	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CYG48_RS00045	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CYG48_RS00050	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CYG48_RS00060	COG1137	ATPase activity
CYG48_RS00065	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
CYG48_RS00080	COG0776	regulation of translation
CYG48_RS00095	COG0116	Belongs to the methyltransferase superfamily
CYG48_RS00095	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CYG48_RS00100	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CYG48_RS00105	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CYG48_RS00110	COG0784	Response regulator, receiver
CYG48_RS00110	COG5002	protein histidine kinase activity
CYG48_RS00110	COG2205	protein histidine kinase activity
CYG48_RS00120	COG0280	phosphate acetyltransferase
CYG48_RS00120	COG0281	malic enzyme
CYG48_RS00125	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CYG48_RS00145	COG0180	Tryptophanyl-tRNA synthetase
CYG48_RS00155	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CYG48_RS00160	COG1214	PFAM Peptidase M22, glycoprotease
CYG48_RS00165	COG0456	acetyltransferase
CYG48_RS00180	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CYG48_RS00185	COG1702	phosphate starvation-inducible protein PhoH
CYG48_RS00190	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CYG48_RS00195	COG1253	flavin adenine dinucleotide binding
CYG48_RS00200	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CYG48_RS00205	COG1396	sequence-specific DNA binding
CYG48_RS00210	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CYG48_RS00215	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CYG48_RS00225	COG0071	Belongs to the small heat shock protein (HSP20) family
CYG48_RS00230	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CYG48_RS00240	COG0242	peptide deformylase activity
CYG48_RS00245	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CYG48_RS00250	COG0101	tRNA pseudouridine synthase activity
CYG48_RS00260	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CYG48_RS00265	COG2171	N-acyltransferase activity
CYG48_RS00290	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CYG48_RS00305	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
CYG48_RS00310	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CYG48_RS00315	COG0706	membrane insertase activity
CYG48_RS00320	COG0594	ribonuclease P activity
CYG48_RS00325	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CYG48_RS00330	COG0840	transmembrane signaling receptor activity
CYG48_RS00355	COG1276	copper resistance
CYG48_RS00360	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CYG48_RS00365	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CYG48_RS00370	COG1028	Short-chain dehydrogenase reductase Sdr
CYG48_RS00375	COG3938	Belongs to the proline racemase family
CYG48_RS00385	COG0418	dihydroorotase activity
CYG48_RS00390	COG3706	GGDEF domain
CYG48_RS00395	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CYG48_RS00405	COG0166	Belongs to the GPI family
CYG48_RS00415	COG0318	PFAM AMP-dependent synthetase and ligase
CYG48_RS00430	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CYG48_RS00435	COG0318	PFAM AMP-dependent synthetase and ligase
CYG48_RS00445	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CYG48_RS00450	COG0579	oxidoreductase
CYG48_RS00455	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CYG48_RS00480	COG2070	2-Nitropropane dioxygenase
CYG48_RS00490	COG2326	polyphosphate kinase activity
CYG48_RS00495	COG5002	protein histidine kinase activity
CYG48_RS00500	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CYG48_RS00515	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CYG48_RS00520	COG0704	Plays a role in the regulation of phosphate uptake
CYG48_RS00525	COG0745	RESPONSE REGULATOR receiver
CYG48_RS00545	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CYG48_RS00550	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CYG48_RS00560	COG2967	ApaG domain
CYG48_RS00570	COG0717	Belongs to the dCTP deaminase family
CYG48_RS00615	COG0167	dihydroorotate dehydrogenase activity
CYG48_RS00620	COG0534	Mate efflux family protein
CYG48_RS00650	COG1201	RNA secondary structure unwinding
CYG48_RS00670	COG0730	response to heat
CYG48_RS00680	COG1960	acyl-CoA dehydrogenase activity
CYG48_RS00685	COG0183	Belongs to the thiolase family
CYG48_RS00690	COG1250	3-hydroxyacyl-CoA dehydrogenase
CYG48_RS00690	COG1024	Enoyl-CoA hydratase
CYG48_RS00720	COG0246	Mannitol dehydrogenase
CYG48_RS00725	COG4948	Mandelate Racemase Muconate Lactonizing
CYG48_RS00730	COG1028	Short-chain dehydrogenase reductase Sdr
CYG48_RS00735	COG1063	alcohol dehydrogenase
CYG48_RS00740	COG2186	Transcriptional regulator
CYG48_RS00745	COG2721	sulfolactate sulfo-lyase activity
CYG48_RS00755	COG2198	Histidine kinase
CYG48_RS00755	COG2205	protein histidine kinase activity
CYG48_RS00755	COG0784	Response regulator, receiver
CYG48_RS00760	COG1970	mechanosensitive ion channel activity
CYG48_RS00765	COG0436	Aminotransferase
CYG48_RS00795	COG4585	Histidine kinase
CYG48_RS00830	COG1132	(ABC) transporter
CYG48_RS00850	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CYG48_RS00855	COG0300	oxidoreductase activity
CYG48_RS00865	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CYG48_RS00870	COG5328	Belongs to the UPF0262 family
CYG48_RS00880	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CYG48_RS00885	COG0424	maF-like protein
CYG48_RS00890	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
CYG48_RS00905	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CYG48_RS00910	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CYG48_RS00920	COG3386	PFAM SMP-30 Gluconolaconase
CYG48_RS00930	COG2094	Belongs to the DNA glycosylase MPG family
CYG48_RS00955	COG0840	transmembrane signaling receptor activity
CYG48_RS00965	COG0745	RESPONSE REGULATOR receiver
CYG48_RS00970	COG0643	Histidine kinase
CYG48_RS00970	COG2198	Histidine kinase
CYG48_RS00975	COG0835	chemotaxis
CYG48_RS00980	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CYG48_RS00985	COG2201	protein-glutamate methylesterase activity
CYG48_RS00990	COG0745	RESPONSE REGULATOR receiver
CYG48_RS00995	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
CYG48_RS01005	COG1766	The M ring may be actively involved in energy transduction
CYG48_RS01010	COG2771	luxR family
CYG48_RS01025	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CYG48_RS01030	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CYG48_RS01035	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CYG48_RS01040	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CYG48_RS01045	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CYG48_RS01055	COG4786	Flagellar basal body rod
CYG48_RS01060	COG1157	protein secretion by the type III secretion system
CYG48_RS01070	COG1815	bacterial-type flagellum-dependent cell motility
CYG48_RS01075	COG1558	bacterial-type flagellum-dependent cell motility
CYG48_RS01080	COG1677	Flagellar hook-basal body complex protein FliE
CYG48_RS01085	COG4786	Flagellar basal body rod
CYG48_RS01090	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
CYG48_RS01095	COG1706	bacterial-type flagellum-dependent cell motility
CYG48_RS01105	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
CYG48_RS01115	COG1338	Plays a role in the flagellum-specific transport system
CYG48_RS01150	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CYG48_RS01160	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CYG48_RS01170	COG1360	Flagellar Motor Protein
CYG48_RS01195	COG1749	Flagellar hook protein flgE
CYG48_RS01215	COG5443	negative regulation of bacterial-type flagellum assembly
CYG48_RS01220	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CYG48_RS01225	COG4794	Type iii secretion
CYG48_RS01230	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CYG48_RS01235	COG1684	flagellar biosynthetic protein fliR
CYG48_RS01265	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CYG48_RS01270	COG1653	transport
CYG48_RS01275	COG1175	transmembrane transport
CYG48_RS01280	COG0395	ABC-type sugar transport system, permease component
CYG48_RS01285	COG0366	Alpha amylase catalytic
CYG48_RS01290	COG3842	ATPase activity
CYG48_RS01300	COG0129	dihydroxy-acid dehydratase activity
CYG48_RS01305	COG0363	glucosamine-6-phosphate deaminase activity
CYG48_RS01310	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CYG48_RS01315	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CYG48_RS01325	COG2081	HI0933 family
CYG48_RS01330	COG0840	transmembrane signaling receptor activity
CYG48_RS01330	COG2972	Histidine kinase
CYG48_RS01345	COG2224	Isocitrate lyase
CYG48_RS01355	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CYG48_RS01360	COG3842	ATPase activity
CYG48_RS01365	COG1176	ABC-type spermidine putrescine transport system, permease component I
CYG48_RS01370	COG1177	transmembrane transport
CYG48_RS01375	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CYG48_RS01380	COG2205	protein histidine kinase activity
CYG48_RS01415	COG1959	2 iron, 2 sulfur cluster binding
CYG48_RS01430	COG3265	gluconokinase activity
CYG48_RS01440	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CYG48_RS01445	COG1028	Short-chain dehydrogenase reductase Sdr
CYG48_RS01450	COG4977	sequence-specific DNA binding
CYG48_RS01455	COG1349	DNA-binding transcription factor activity
CYG48_RS01460	COG0784	Response regulator, receiver
CYG48_RS01460	COG4191	Histidine kinase
CYG48_RS01470	COG1653	transport
CYG48_RS01475	COG1175	transmembrane transport
CYG48_RS01480	COG0395	ABC-type sugar transport system, permease component
CYG48_RS01485	COG1063	alcohol dehydrogenase
CYG48_RS01490	COG3842	ATPase activity
CYG48_RS01525	COG0248	Ppx GppA phosphatase
CYG48_RS01530	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
CYG48_RS01535	COG0477	Major facilitator Superfamily
CYG48_RS01550	COG0412	Dienelactone hydrolase
CYG48_RS01555	COG0583	DNA-binding transcription factor activity
CYG48_RS01580	COG0306	phosphate transporter
CYG48_RS01595	COG1376	ErfK ybiS ycfS ynhG family protein
CYG48_RS01600	COG1376	ErfK ybiS ycfS ynhG family protein
CYG48_RS01605	COG2818	Glycosylase
CYG48_RS01625	COG0124	histidyl-tRNA synthetase
CYG48_RS01630	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
CYG48_RS01635	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CYG48_RS01645	COG0025	NhaP-type Na H and K H
CYG48_RS01660	COG0459	protein refolding
CYG48_RS01665	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CYG48_RS01675	COG0196	riboflavin kinase activity
CYG48_RS01680	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CYG48_RS01690	COG0590	tRNA wobble adenosine to inosine editing
CYG48_RS01695	COG1187	pseudouridine synthase activity
CYG48_RS01700	COG0742	ribosomal rna small subunit methyltransferase
CYG48_RS01715	COG0312	modulator of DNA gyrase
CYG48_RS01720	COG0483	inositol monophosphate 1-phosphatase activity
CYG48_RS01730	COG1519	Transferase
CYG48_RS01740	COG1663	tetraacyldisaccharide 4'-kinase activity
CYG48_RS01750	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CYG48_RS01760	COG5001	Diguanylate cyclase
CYG48_RS01770	COG3386	PFAM SMP-30 Gluconolaconase
CYG48_RS01775	COG2197	response regulator
CYG48_RS01780	COG0489	protein tyrosine kinase activity
CYG48_RS01785	COG0598	Magnesium transport protein CorA
CYG48_RS01790	COG3158	transport of potassium into the cell
CYG48_RS01805	COG0356	it plays a direct role in the translocation of protons across the membrane
CYG48_RS01810	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CYG48_RS01815	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CYG48_RS01820	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CYG48_RS01825	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CYG48_RS01840	COG0521	Mo-molybdopterin cofactor biosynthetic process
CYG48_RS01845	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CYG48_RS01855	COG0142	geranyltranstransferase activity
CYG48_RS01870	COG1914	H( )-stimulated, divalent metal cation uptake system
CYG48_RS01885	COG0752	glycyl-tRNA synthetase alpha subunit
CYG48_RS01890	COG1704	LemA family
CYG48_RS01895	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CYG48_RS01905	COG0751	glycine-tRNA ligase activity
CYG48_RS01910	COG0840	transmembrane signaling receptor activity
CYG48_RS01920	COG0151	Belongs to the GarS family
CYG48_RS01925	COG2183	response to ionizing radiation
CYG48_RS01930	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CYG48_RS01935	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CYG48_RS01955	COG0009	L-threonylcarbamoyladenylate synthase
CYG48_RS01965	COG4638	Rieske (2fe-2S)
CYG48_RS01970	COG1960	acyl-CoA dehydrogenase activity
CYG48_RS01985	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CYG48_RS01990	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
CYG48_RS01995	COG0840	transmembrane signaling receptor activity
CYG48_RS02005	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CYG48_RS02010	COG1741	Belongs to the pirin family
CYG48_RS02035	COG2358	TRAP transporter, solute receptor (TAXI family
CYG48_RS02040	COG1722	exodeoxyribonuclease VII activity
CYG48_RS02045	COG0123	including yeast histone deacetylase and acetoin utilization protein
CYG48_RS02055	COG1268	BioY protein
CYG48_RS02060	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CYG48_RS02065	COG1122	ATPase activity
CYG48_RS02070	COG3214	Protein conserved in bacteria
CYG48_RS02075	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CYG48_RS02080	COG0366	Alpha amylase catalytic
CYG48_RS02085	COG0366	Alpha amylase catalytic
CYG48_RS02100	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CYG48_RS02100	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CYG48_RS02105	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CYG48_RS02120	COG0406	alpha-ribazole phosphatase activity
CYG48_RS02125	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CYG48_RS02130	COG0484	heat shock protein binding
CYG48_RS02140	COG0259	pyridoxamine-phosphate oxidase activity
CYG48_RS02150	COG0312	modulator of DNA gyrase
CYG48_RS02160	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CYG48_RS02160	COG1565	acr, cog1565
CYG48_RS02165	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CYG48_RS02170	COG0109	protoheme IX farnesyltransferase activity
CYG48_RS02180	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
CYG48_RS02190	COG3346	SURF1 family
CYG48_RS02195	COG3759	membrane
CYG48_RS02200	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CYG48_RS02205	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CYG48_RS02210	COG0328	RNA-DNA hybrid ribonuclease activity
CYG48_RS02220	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CYG48_RS02220	COG0678	peroxiredoxin activity
CYG48_RS02230	COG1678	Uncharacterized ACR, COG1678
CYG48_RS02245	COG3300	MHYT domain
CYG48_RS02245	COG5001	Diguanylate cyclase
CYG48_RS02250	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CYG48_RS02255	COG0612	Peptidase, M16
CYG48_RS02275	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CYG48_RS02300	COG2189	Belongs to the N(4) N(6)-methyltransferase family
CYG48_RS02320	COG1194	a g-specific adenine glycosylase
CYG48_RS02335	COG1196	nuclear chromosome segregation
CYG48_RS02340	COG0574	Belongs to the PEP-utilizing enzyme family
CYG48_RS02340	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CYG48_RS02365	COG1216	Glycosyl transferase, family 2
CYG48_RS02365	COG0438	transferase activity, transferring glycosyl groups
CYG48_RS02370	COG1215	transferase activity, transferring glycosyl groups
CYG48_RS02380	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CYG48_RS02385	COG1091	dTDP-4-dehydrorhamnose reductase activity
CYG48_RS02390	COG1088	dTDP-glucose 4,6-dehydratase activity
CYG48_RS02395	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
CYG48_RS02400	COG1216	Glycosyl transferase, family 2
CYG48_RS02400	COG0438	transferase activity, transferring glycosyl groups
CYG48_RS02445	COG2895	sulfate adenylyltransferase (ATP) activity
CYG48_RS02450	COG0175	sulfate reduction
CYG48_RS02455	COG0175	sulfate reduction
CYG48_RS02460	COG1959	2 iron, 2 sulfur cluster binding
CYG48_RS02465	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CYG48_RS02470	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
CYG48_RS02475	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
CYG48_RS02480	COG4208	sulfate ABC transporter
CYG48_RS02485	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CYG48_RS02500	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
CYG48_RS02505	COG1012	belongs to the aldehyde dehydrogenase family
CYG48_RS02510	COG3119	arylsulfatase activity
CYG48_RS02515	COG3549	Plasmid maintenance system killer
CYG48_RS02520	COG3093	addiction module antidote protein HigA
CYG48_RS02525	COG3321	synthase
CYG48_RS02525	COG1028	Short-chain dehydrogenase reductase Sdr
CYG48_RS02525	COG0604	alcohol dehydrogenase
CYG48_RS02555	COG0583	DNA-binding transcription factor activity
CYG48_RS02560	COG0625	glutathione transferase activity
CYG48_RS02580	COG5001	Diguanylate cyclase
CYG48_RS02590	COG0477	Major facilitator Superfamily
CYG48_RS02600	COG1793	dna ligase
CYG48_RS02610	COG1376	ErfK ybiS ycfS ynhG family protein
CYG48_RS02615	COG1376	ErfK ybiS ycfS ynhG family protein
CYG48_RS02620	COG1846	Transcriptional regulator
CYG48_RS02625	COG1764	response to oxidative stress
CYG48_RS02650	COG2824	Alkylphosphonate utilization operon protein PhnA
CYG48_RS02655	COG0433	COG0433 Predicted ATPase
CYG48_RS02660	COG1295	ribonuclease BN
CYG48_RS02660	COG1959	2 iron, 2 sulfur cluster binding
CYG48_RS02685	COG0656	L-ascorbic acid biosynthetic process
CYG48_RS02690	COG0667	Aldo Keto reductase
CYG48_RS02695	COG2814	Major facilitator Superfamily
CYG48_RS02710	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CYG48_RS02725	COG0730	response to heat
CYG48_RS02730	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CYG48_RS02755	COG1280	lysine exporter protein (LysE YggA)
CYG48_RS02765	COG2010	Cytochrome c
CYG48_RS02815	COG2514	catechol 2,3-dioxygenase activity
CYG48_RS02820	COG1272	protein, Hemolysin III
CYG48_RS02845	COG0583	DNA-binding transcription factor activity
CYG48_RS02855	COG1309	transcriptional regulator
CYG48_RS02860	COG1028	Short-chain dehydrogenase reductase Sdr
CYG48_RS02865	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CYG48_RS02870	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CYG48_RS02870	COG2111	Na H antiporter
CYG48_RS02875	COG2111	Na H antiporter
CYG48_RS02880	COG1006	Multisubunit Na H antiporter MnhC subunit
CYG48_RS02885	COG0651	ATP synthesis coupled electron transport
CYG48_RS02890	COG1863	multisubunit Na H antiporter MnhE subunit
CYG48_RS02895	COG2212	antiporter activity
CYG48_RS02900	COG1320	monovalent cation:proton antiporter activity
CYG48_RS02905	COG4957	zinc ion binding
CYG48_RS02910	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CYG48_RS02920	COG2166	iron-sulfur cluster assembly
CYG48_RS02930	COG2205	protein histidine kinase activity
CYG48_RS02970	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CYG48_RS02975	COG2983	Belongs to the UPF0260 family
CYG48_RS02990	COG2026	Addiction module toxin, RelE StbE family
CYG48_RS03015	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CYG48_RS03050	COG4695	Portal protein
CYG48_RS03120	COG4235	cytochrome complex assembly
CYG48_RS03125	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
CYG48_RS03130	COG1138	Cytochrome C-type biogenesis protein
CYG48_RS03135	COG3088	subunit of a heme lyase
CYG48_RS03140	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CYG48_RS03145	COG0745	RESPONSE REGULATOR receiver
CYG48_RS03150	COG2205	protein histidine kinase activity
CYG48_RS03155	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
CYG48_RS03160	COG2202	Pas domain
CYG48_RS03160	COG2205	protein histidine kinase activity
CYG48_RS03165	COG0308	aminopeptidase N
CYG48_RS03185	COG0443	Heat shock 70 kDa protein
CYG48_RS03225	COG1376	ErfK ybiS ycfS ynhG family protein
CYG48_RS03240	COG2814	Major facilitator Superfamily
CYG48_RS03250	COG0174	glutamine synthetase
CYG48_RS03260	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CYG48_RS03265	COG0463	Glycosyl transferase, family 2
CYG48_RS03275	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CYG48_RS03320	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CYG48_RS03345	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CYG48_RS03350	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CYG48_RS03365	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CYG48_RS03370	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CYG48_RS03385	COG0392	lysyltransferase activity
CYG48_RS03395	COG1758	RNA polymerase activity
CYG48_RS03405	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CYG48_RS03410	COG0586	Pfam SNARE associated Golgi protein
CYG48_RS03420	COG0736	holo-[acyl-carrier-protein] synthase activity
CYG48_RS03425	COG0681	Belongs to the peptidase S26 family
CYG48_RS03430	COG0571	ribonuclease III activity
CYG48_RS03435	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CYG48_RS03445	COG1381	Involved in DNA repair and RecF pathway recombination
CYG48_RS03465	COG1418	mRNA catabolic process
CYG48_RS03475	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
CYG48_RS03480	COG4251	negative regulation of phosphorylation
CYG48_RS03485	COG3920	Histidine kinase
CYG48_RS03485	COG2202	Pas domain
CYG48_RS03500	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CYG48_RS03505	COG0840	transmembrane signaling receptor activity
CYG48_RS03510	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CYG48_RS03515	COG5642	Protein of unknown function (DUF2384)
CYG48_RS03525	COG0668	transmembrane transport
CYG48_RS03535	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
CYG48_RS03575	COG1742	UPF0060 membrane protein
CYG48_RS03580	COG2135	peptidase activity
CYG48_RS03585	COG1183	phosphatidylcholine synthase activity
CYG48_RS03590	COG0688	phosphatidylethanolamine metabolic process
CYG48_RS03595	COG1126	abc transporter atp-binding protein
CYG48_RS03600	COG0765	amino acid transport
CYG48_RS03605	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CYG48_RS03610	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CYG48_RS03615	COG5265	(ABC) transporter
CYG48_RS03620	COG1652	LysM domain
CYG48_RS03635	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CYG48_RS03660	COG0215	cysteine-tRNA ligase activity
CYG48_RS03665	COG4221	oxidoreductase activity
CYG48_RS03670	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CYG48_RS03685	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CYG48_RS03700	COG0359	binds to the 23S rRNA
CYG48_RS03710	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CYG48_RS03715	COG0360	Binds together with S18 to 16S ribosomal RNA
CYG48_RS03730	COG0667	Aldo Keto reductase
CYG48_RS03740	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CYG48_RS03750	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CYG48_RS03755	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CYG48_RS03760	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CYG48_RS03765	COG1561	YicC-like family, N-terminal region
CYG48_RS03770	COG0194	GDP metabolic process
CYG48_RS03780	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CYG48_RS03785	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CYG48_RS03795	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CYG48_RS03810	COG0671	phosphoesterase, PA-phosphatase related
CYG48_RS03815	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CYG48_RS03825	COG1505	serine-type exopeptidase activity
CYG48_RS03840	COG0488	(ABC) transporter
CYG48_RS03855	COG0105	UTP biosynthetic process
CYG48_RS03875	COG0314	molybdopterin synthase activity
CYG48_RS03885	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CYG48_RS03890	COG0322	excinuclease ABC activity
CYG48_RS03915	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
CYG48_RS03920	COG0243	molybdopterin cofactor binding
CYG48_RS03940	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CYG48_RS03945	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CYG48_RS03950	COG0628	permease
CYG48_RS03960	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CYG48_RS03975	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
CYG48_RS03985	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CYG48_RS04005	COG0659	secondary active sulfate transmembrane transporter activity
CYG48_RS04015	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CYG48_RS04020	COG3654	unkown
CYG48_RS04025	COG2336	PFAM SpoVT AbrB
CYG48_RS04030	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
CYG48_RS04040	COG0113	porphobilinogen synthase activity
CYG48_RS04065	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CYG48_RS04070	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CYG48_RS04075	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CYG48_RS04075	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CYG48_RS04085	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CYG48_RS04090	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CYG48_RS04095	COG2814	Major facilitator Superfamily
CYG48_RS04100	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
CYG48_RS04120	COG0416	fatty acid biosynthetic process
CYG48_RS04125	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CYG48_RS04130	COG0776	regulation of translation
CYG48_RS04195	COG0438	transferase activity, transferring glycosyl groups
CYG48_RS04220	COG1612	heme a metabolic process
CYG48_RS04230	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CYG48_RS04235	COG0010	Belongs to the arginase family
CYG48_RS04240	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CYG48_RS04245	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CYG48_RS04255	COG1832	CoA-binding protein
CYG48_RS04275	COG1028	Short-chain dehydrogenase reductase Sdr
CYG48_RS04295	COG0740	serine-type endopeptidase activity
CYG48_RS04300	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CYG48_RS04305	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CYG48_RS04315	COG0667	Aldo Keto reductase
CYG48_RS04320	COG0420	3'-5' exonuclease activity
CYG48_RS04325	COG4717	serine-type aminopeptidase activity
CYG48_RS04340	COG0604	alcohol dehydrogenase
CYG48_RS04340	COG3321	synthase
CYG48_RS04340	COG1028	Short-chain dehydrogenase reductase Sdr
CYG48_RS04345	COG0156	8-amino-7-oxononanoate synthase activity
CYG48_RS04350	COG1028	Short-chain dehydrogenase reductase Sdr
CYG48_RS04355	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CYG48_RS04360	COG0489	protein tyrosine kinase activity
CYG48_RS04360	COG3206	protein involved in exopolysaccharide biosynthesis
CYG48_RS04370	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CYG48_RS04375	COG0297	glycogen (starch) synthase activity
CYG48_RS04430	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CYG48_RS04435	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CYG48_RS04440	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CYG48_RS04445	COG0649	NAD binding
CYG48_RS04455	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
CYG48_RS04460	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
CYG48_RS04465	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CYG48_RS04465	COG3743	rRNA binding
CYG48_RS04475	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CYG48_RS04480	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CYG48_RS04505	COG1007	ATP synthesis coupled electron transport
CYG48_RS04520	COG0346	lactoylglutathione lyase activity
CYG48_RS04530	COG0442	prolyl-tRNA aminoacylation
CYG48_RS04540	COG1136	(ABC) transporter
CYG48_RS04560	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CYG48_RS04575	COG0784	Response regulator, receiver
CYG48_RS04590	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CYG48_RS04610	COG0557	exoribonuclease II activity
CYG48_RS04615	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CYG48_RS04625	COG0758	DNA mediated transformation
CYG48_RS04630	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CYG48_RS04640	COG0540	Belongs to the ATCase OTCase family
CYG48_RS04645	COG1960	acyl-CoA dehydrogenase activity
CYG48_RS04665	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CYG48_RS04670	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CYG48_RS04675	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CYG48_RS04680	COG0154	amidase activity
CYG48_RS04695	COG3811	Belongs to the UPF0386 family
CYG48_RS04705	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CYG48_RS04725	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
CYG48_RS04735	COG0511	ligase activity, forming carbon-carbon bonds
CYG48_RS04740	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CYG48_RS04750	COG1530	ribonuclease E activity
CYG48_RS04755	COG0860	N-Acetylmuramoyl-L-alanine amidase
CYG48_RS04770	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CYG48_RS04920	COG0305	Participates in initiation and elongation during chromosome replication
CYG48_RS05090	COG3179	chitinase
CYG48_RS05120	COG1525	nuclease
CYG48_RS05145	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CYG48_RS05150	COG1218	3'(2'),5'-bisphosphate nucleotidase
CYG48_RS05155	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CYG48_RS05170	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CYG48_RS05190	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CYG48_RS05200	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CYG48_RS05205	COG0081	regulation of translation
CYG48_RS05210	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CYG48_RS05215	COG0222	ribosome binding
CYG48_RS05220	COG0085	RNA polymerase activity
CYG48_RS05225	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CYG48_RS05235	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CYG48_RS05240	COG0049	tRNA binding
CYG48_RS05245	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CYG48_RS05250	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CYG48_RS05255	COG0051	transcription antitermination factor activity, RNA binding
CYG48_RS05260	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CYG48_RS05265	COG0088	Forms part of the polypeptide exit tunnel
CYG48_RS05270	COG0089	rRNA binding
CYG48_RS05275	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CYG48_RS05280	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CYG48_RS05285	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CYG48_RS05290	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CYG48_RS05295	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CYG48_RS05300	COG0255	Belongs to the universal ribosomal protein uL29 family
CYG48_RS05305	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CYG48_RS05315	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CYG48_RS05320	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CYG48_RS05325	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CYG48_RS05330	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CYG48_RS05335	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CYG48_RS05340	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CYG48_RS05345	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CYG48_RS05350	COG1841	ribosomal large subunit assembly
CYG48_RS05355	COG0200	Binds to the 23S rRNA
CYG48_RS05365	COG0563	adenylate kinase activity
CYG48_RS05370	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CYG48_RS05375	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CYG48_RS05380	COG0202	RNA polymerase activity
CYG48_RS05385	COG0203	ribosomal protein L17
CYG48_RS05390	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
CYG48_RS05395	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CYG48_RS05405	COG0129	dihydroxy-acid dehydratase activity
CYG48_RS05415	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CYG48_RS05420	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CYG48_RS05435	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CYG48_RS05465	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CYG48_RS05470	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
CYG48_RS05480	COG1546	Belongs to the CinA family
CYG48_RS05480	COG1058	Belongs to the CinA family
CYG48_RS05485	COG0655	NAD(P)H dehydrogenase (quinone) activity
CYG48_RS05500	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CYG48_RS05555	COG1793	dna ligase
CYG48_RS05555	COG3285	dna ligase
CYG48_RS05590	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CYG48_RS05595	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CYG48_RS05600	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CYG48_RS05620	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CYG48_RS05625	COG0583	DNA-binding transcription factor activity
CYG48_RS05635	COG0737	Belongs to the 5'-nucleotidase family
CYG48_RS05655	COG0686	Belongs to the AlaDH PNT family
CYG48_RS05660	COG1695	Transcriptional regulator
CYG48_RS05680	COG2897	thiosulfate sulfurtransferase activity
CYG48_RS05695	COG3806	Anti-sigma factor
CYG48_RS05705	COG0306	phosphate transporter
CYG48_RS05710	COG1392	Phosphate transport regulator
CYG48_RS05750	COG0673	inositol 2-dehydrogenase activity
CYG48_RS05765	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CYG48_RS05790	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CYG48_RS05795	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CYG48_RS05800	COG4221	oxidoreductase activity
CYG48_RS05805	COG1335	isochorismatase
CYG48_RS05820	COG0582	viral genome integration into host DNA
CYG48_RS05925	COG3932	Exopolysaccharide synthesis, ExoD
CYG48_RS05955	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CYG48_RS05965	COG0525	valine-tRNA ligase activity
CYG48_RS05985	COG0316	Belongs to the HesB IscA family
CYG48_RS05990	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CYG48_RS05995	COG0018	arginyl-trna synthetase
CYG48_RS06010	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CYG48_RS06020	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CYG48_RS06025	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CYG48_RS06030	COG0805	protein transport
CYG48_RS06035	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CYG48_RS06040	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CYG48_RS06045	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CYG48_RS06050	COG3584	3D domain protein
CYG48_RS06050	COG1388	LysM domain
CYG48_RS06060	COG1862	Preprotein translocase
CYG48_RS06080	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
CYG48_RS06100	COG0544	peptidyl-prolyl cis-trans isomerase activity
CYG48_RS06105	COG0488	(ABC) transporter
CYG48_RS06125	COG0538	isocitrate dehydrogenase activity
CYG48_RS06140	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CYG48_RS06145	COG1280	lysine exporter protein (LysE YggA)
CYG48_RS06155	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CYG48_RS06165	COG2003	Belongs to the UPF0758 family
CYG48_RS06170	COG0024	Methionine aminopeptidase
CYG48_RS06175	COG3243	poly(R)-hydroxyalkanoic acid synthase
CYG48_RS06185	COG0436	Aminotransferase
CYG48_RS06195	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CYG48_RS06195	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CYG48_RS06220	COG1278	Cold shock
CYG48_RS06250	COG1126	abc transporter atp-binding protein
CYG48_RS06255	COG0765	amino acid transport
CYG48_RS06260	COG4597	amino acid ABC transporter
CYG48_RS06265	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CYG48_RS06270	COG0626	cystathionine gamma-synthase activity
CYG48_RS06285	COG2267	carboxylic ester hydrolase activity
CYG48_RS06290	COG1045	serine acetyltransferase
CYG48_RS06305	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CYG48_RS06330	COG0537	adenosine 5'-monophosphoramidase activity
CYG48_RS06355	COG1280	lysine exporter protein (LysE YggA)
CYG48_RS06365	COG0052	Belongs to the universal ribosomal protein uS2 family
CYG48_RS06370	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CYG48_RS06375	COG0528	UMP kinase activity
CYG48_RS06380	COG0233	cytoplasmic translational termination
CYG48_RS06385	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CYG48_RS06395	COG0750	zinc metalloprotease
CYG48_RS06405	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CYG48_RS06410	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CYG48_RS06415	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CYG48_RS06420	COG3494	Protein of unknown function (DUF1009)
CYG48_RS06425	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CYG48_RS06440	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CYG48_RS06445	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CYG48_RS06450	COG1840	ABC-type Fe3 transport system, periplasmic component
CYG48_RS06455	COG1176	ABC-type spermidine putrescine transport system, permease component I
CYG48_RS06460	COG3842	ATPase activity
CYG48_RS06475	COG0384	phenazine biosynthesis protein PhzF
CYG48_RS06500	COG0531	amino acid
CYG48_RS06505	COG1238	metal cluster binding
CYG48_RS06520	COG0861	Integral membrane protein TerC family
CYG48_RS06535	COG4702	Belongs to the UPF0303 family
CYG48_RS06550	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
CYG48_RS06550	COG3264	Mechanosensitive ion channel
CYG48_RS06560	COG0745	RESPONSE REGULATOR receiver
CYG48_RS06580	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
CYG48_RS06585	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CYG48_RS06610	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CYG48_RS06615	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CYG48_RS06625	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CYG48_RS06650	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CYG48_RS06655	COG0667	Aldo Keto reductase
CYG48_RS06660	COG3507	Belongs to the glycosyl hydrolase 43 family
CYG48_RS06675	COG1121	(ABC) transporter
CYG48_RS06680	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CYG48_RS06700	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CYG48_RS06705	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CYG48_RS06710	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CYG48_RS06715	COG0037	tRNA processing
CYG48_RS06720	COG0483	inositol monophosphate 1-phosphatase activity
CYG48_RS06725	COG2814	Major facilitator Superfamily
CYG48_RS06745	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CYG48_RS06760	COG0047	phosphoribosylformylglycinamidine synthase activity
CYG48_RS06765	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CYG48_RS06770	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CYG48_RS06785	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CYG48_RS06805	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CYG48_RS06820	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CYG48_RS06820	COG3608	succinylglutamate desuccinylase aspartoacylase
CYG48_RS06825	COG0746	molybdenum cofactor guanylyltransferase activity
CYG48_RS06840	COG0513	Belongs to the DEAD box helicase family
CYG48_RS06845	COG0739	heme binding
CYG48_RS06850	COG2833	Protein of unknown function (DUF455)
CYG48_RS06855	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CYG48_RS06865	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CYG48_RS06870	COG3706	GGDEF domain
CYG48_RS06875	COG2945	thiolester hydrolase activity
CYG48_RS06880	COG1104	cysteine desulfurase activity
CYG48_RS06885	COG0719	Fe-S assembly protein
CYG48_RS06890	COG0396	ATPase activity
CYG48_RS06895	COG0719	Fe-S assembly protein
CYG48_RS06900	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CYG48_RS06905	COG2151	metal-sulfur cluster biosynthetic enzyme
CYG48_RS06915	COG0577	efflux transmembrane transporter activity
CYG48_RS06915	COG1136	(ABC) transporter
CYG48_RS06920	COG0577	efflux transmembrane transporter activity
CYG48_RS06920	COG1136	(ABC) transporter
CYG48_RS06925	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CYG48_RS06955	COG0785	Cytochrome C biogenesis protein
CYG48_RS06960	COG0679	Auxin Efflux Carrier
CYG48_RS06965	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CYG48_RS06970	COG1183	phosphatidylcholine synthase activity
CYG48_RS06975	COG3845	ABC transporter
CYG48_RS06980	COG4603	Belongs to the binding-protein-dependent transport system permease family
CYG48_RS06985	COG1079	Belongs to the binding-protein-dependent transport system permease family
CYG48_RS06995	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CYG48_RS07000	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CYG48_RS07010	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CYG48_RS07020	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CYG48_RS07050	COG0174	glutamine synthetase
CYG48_RS07055	COG0347	Belongs to the P(II) protein family
CYG48_RS07060	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CYG48_RS07060	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CYG48_RS07070	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CYG48_RS07075	COG0629	single-stranded DNA binding
CYG48_RS07080	COG2095	MarC family integral membrane protein
CYG48_RS07085	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CYG48_RS07095	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CYG48_RS07110	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CYG48_RS07115	COG0343	queuine tRNA-ribosyltransferase activity
CYG48_RS07125	COG0484	heat shock protein binding
CYG48_RS07140	COG2801	Transposase and inactivated derivatives
CYG48_RS07145	COG0321	lipoyl(octanoyl) transferase activity
CYG48_RS07145	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CYG48_RS07150	COG0084	hydrolase, TatD family'
CYG48_RS07155	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CYG48_RS07165	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CYG48_RS07170	COG1686	Belongs to the peptidase S11 family
CYG48_RS07220	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CYG48_RS07225	COG0134	indole-3-glycerol-phosphate synthase activity
CYG48_RS07230	COG0315	cyclic pyranopterin monophosphate synthase activity
CYG48_RS07235	COG0303	'Molybdopterin
CYG48_RS07240	COG0415	Belongs to the DNA photolyase family
CYG48_RS07255	COG0372	Belongs to the citrate synthase family
CYG48_RS07270	COG3106	COG3106 Predicted ATPase
CYG48_RS07275	COG3768	UPF0283 membrane protein
CYG48_RS07285	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CYG48_RS07290	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CYG48_RS07295	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CYG48_RS07305	COG0633	Ferredoxin
CYG48_RS07330	COG1127	ABC transporter
CYG48_RS07335	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CYG48_RS07340	COG4948	Mandelate Racemase Muconate Lactonizing
CYG48_RS07350	COG0281	malic enzyme
CYG48_RS07350	COG0280	phosphate acetyltransferase
CYG48_RS07360	COG0823	Involved in the tonB-independent uptake of proteins
CYG48_RS07370	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
CYG48_RS07380	COG1733	regulation of RNA biosynthetic process
CYG48_RS07390	COG1794	racemase activity, acting on amino acids and derivatives
CYG48_RS07395	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CYG48_RS07400	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CYG48_RS07420	COG1280	lysine exporter protein (LysE YggA)
CYG48_RS07425	COG0656	L-ascorbic acid biosynthetic process
CYG48_RS07435	COG0440	acetolactate synthase activity
CYG48_RS07440	COG0028	Belongs to the TPP enzyme family
CYG48_RS07450	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CYG48_RS07455	COG0560	Phosphoserine phosphatase
CYG48_RS07470	COG0330	HflC and HflK could
CYG48_RS07475	COG0330	HflC and HflK could
CYG48_RS07480	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CYG48_RS07490	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CYG48_RS07515	COG1410	methionine synthase
CYG48_RS07515	COG0646	methionine synthase
CYG48_RS07530	COG5598	trimethylamine methyltransferase
CYG48_RS07535	COG5012	cobalamin binding
CYG48_RS07560	COG0646	methionine synthase
CYG48_RS07560	COG1410	methionine synthase
CYG48_RS07570	COG0583	DNA-binding transcription factor activity
CYG48_RS07585	COG0842	Transport permease protein
CYG48_RS07590	COG1131	(ABC) transporter
CYG48_RS07595	COG0730	response to heat
CYG48_RS07610	COG1607	acyl-coa hydrolase
CYG48_RS07630	COG0556	nucleotide-excision repair
CYG48_RS07670	COG0504	CTP synthase activity
CYG48_RS07680	COG0149	triose-phosphate isomerase activity
CYG48_RS07690	COG0187	DNA topoisomerase II activity
CYG48_RS07700	COG0628	permease
CYG48_RS07710	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CYG48_RS07725	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CYG48_RS07730	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CYG48_RS07740	COG0302	gtp cyclohydrolase
CYG48_RS07745	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CYG48_RS07750	COG1752	Esterase of the alpha-beta hydrolase superfamily
CYG48_RS07785	COG1686	Belongs to the peptidase S11 family
CYG48_RS07800	COG1760	l-serine dehydratase
CYG48_RS07820	COG2239	Acts as a magnesium transporter
CYG48_RS07825	COG0242	peptide deformylase activity
CYG48_RS07840	COG0321	lipoyl(octanoyl) transferase activity
CYG48_RS07875	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
CYG48_RS07880	COG2153	protein acetylation
CYG48_RS07885	COG1671	Belongs to the UPF0178 family
CYG48_RS07890	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
CYG48_RS07915	COG0546	phosphoglycolate phosphatase activity
CYG48_RS07925	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CYG48_RS07940	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CYG48_RS07945	COG0509	glycine decarboxylation via glycine cleavage system
CYG48_RS07950	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CYG48_RS07950	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CYG48_RS07975	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CYG48_RS07975	COG1648	precorrin-2 dehydrogenase activity
CYG48_RS07985	COG3956	TIGRFAM MazG family protein
CYG48_RS07990	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CYG48_RS07995	COG1923	regulation of RNA biosynthetic process
CYG48_RS08000	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CYG48_RS08005	COG0569	domain protein
CYG48_RS08010	COG2204	response regulator
CYG48_RS08015	COG5000	phosphorelay sensor kinase activity
CYG48_RS08020	COG2204	response regulator
CYG48_RS08025	COG3852	Histidine kinase
CYG48_RS08035	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CYG48_RS08035	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CYG48_RS08040	COG1546	Belongs to the CinA family
CYG48_RS08055	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CYG48_RS08065	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CYG48_RS08075	COG0508	dehydrogenase complex catalyzes the overall conversion of
CYG48_RS08080	COG0022	dehydrogenase e1 component
CYG48_RS08080	COG0508	dehydrogenase complex catalyzes the overall conversion of
CYG48_RS08085	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CYG48_RS08095	COG0148	phosphopyruvate hydratase activity
CYG48_RS08100	COG2877	3-deoxy-8-phosphooctulonate synthase activity
CYG48_RS08110	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CYG48_RS08120	COG0372	Belongs to the citrate synthase family
CYG48_RS08130	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CYG48_RS08135	COG0546	phosphoglycolate phosphatase activity
CYG48_RS08140	COG2989	Protein conserved in bacteria
CYG48_RS08145	COG0114	fumarate hydratase activity
CYG48_RS08150	COG3706	GGDEF domain
CYG48_RS08165	COG1846	Transcriptional regulator
CYG48_RS08175	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CYG48_RS08185	COG2814	Major facilitator Superfamily
CYG48_RS08190	COG0746	molybdenum cofactor guanylyltransferase activity
CYG48_RS08195	COG1763	Mo-molybdopterin cofactor biosynthetic process
CYG48_RS08205	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CYG48_RS08220	COG5425	PFAM Usg family protein
CYG48_RS08255	COG2084	Dehydrogenase
CYG48_RS08260	COG1522	sequence-specific DNA binding
CYG48_RS08265	COG1573	uracil-dna glycosylase
CYG48_RS08275	COG2202	Pas domain
CYG48_RS08275	COG2205	protein histidine kinase activity
CYG48_RS08285	COG0277	FAD linked oxidase domain protein
CYG48_RS08300	COG0210	DNA helicase
CYG48_RS08305	COG1473	amidohydrolase
CYG48_RS08315	COG1335	isochorismatase
CYG48_RS08330	COG0006	proline dipeptidase activity
CYG48_RS08340	COG2264	protein methyltransferase activity
CYG48_RS08345	COG1999	signal sequence binding
CYG48_RS08350	COG0835	chemotaxis
CYG48_RS08365	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CYG48_RS08370	COG0497	DNA recombination
CYG48_RS08375	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CYG48_RS08385	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CYG48_RS08390	COG0849	cell division
CYG48_RS08395	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CYG48_RS08400	COG1181	Belongs to the D-alanine--D-alanine ligase family
CYG48_RS08405	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CYG48_RS08410	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CYG48_RS08415	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CYG48_RS08425	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CYG48_RS08430	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CYG48_RS08440	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CYG48_RS08455	COG0275	rRNA processing
CYG48_RS08460	COG2001	Belongs to the MraZ family
CYG48_RS08480	COG3023	N-Acetylmuramoyl-L-alanine amidase
CYG48_RS08485	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CYG48_RS08535	COG0840	transmembrane signaling receptor activity
CYG48_RS08545	COG2267	carboxylic ester hydrolase activity
CYG48_RS08550	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CYG48_RS08560	COG0251	oxidation-reduction process
CYG48_RS08575	COG1376	ErfK ybiS ycfS ynhG family protein
CYG48_RS08595	COG0174	glutamine synthetase
CYG48_RS08605	COG1737	Transcriptional regulator
CYG48_RS08625	COG3842	ATPase activity
CYG48_RS08640	COG0784	Response regulator, receiver
CYG48_RS08640	COG4191	Histidine kinase
CYG48_RS08650	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CYG48_RS08660	COG0601	transmembrane transport
CYG48_RS08665	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CYG48_RS08675	COG4172	Belongs to the ABC transporter superfamily
CYG48_RS08680	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CYG48_RS08685	COG0346	lactoylglutathione lyase activity
CYG48_RS08690	COG4214	carbohydrate transport
CYG48_RS08700	COG4213	ABC transporter substrate-binding protein
CYG48_RS08705	COG0129	dihydroxy-acid dehydratase activity
CYG48_RS08720	COG1879	ABC-type sugar transport system periplasmic component
CYG48_RS08725	COG1129	ABC transporter
CYG48_RS08730	COG1172	Belongs to the binding-protein-dependent transport system permease family
CYG48_RS08735	COG1172	Belongs to the binding-protein-dependent transport system permease family
CYG48_RS08740	COG2186	Transcriptional regulator
CYG48_RS08755	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CYG48_RS08760	COG2186	Transcriptional regulator
CYG48_RS08765	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CYG48_RS08770	COG4948	Mandelate Racemase Muconate Lactonizing
CYG48_RS08775	COG3618	amidohydrolase
CYG48_RS08780	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CYG48_RS08800	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CYG48_RS08805	COG3734	2-keto-3-deoxy-galactonokinase
CYG48_RS08810	COG0800	Aldolase
CYG48_RS08815	COG2226	methyltransferase
CYG48_RS08820	COG1737	Transcriptional regulator
CYG48_RS08825	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CYG48_RS08830	COG2971	BadF BadG BcrA BcrD
CYG48_RS08835	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CYG48_RS08850	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CYG48_RS08865	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
CYG48_RS08870	COG0697	spore germination
CYG48_RS08875	COG1174	glycine betaine transport
CYG48_RS08880	COG1125	glycine betaine transport
CYG48_RS08885	COG1174	glycine betaine transport
CYG48_RS08890	COG1732	Glycine betaine
CYG48_RS09005	COG2968	Membrane
CYG48_RS09015	COG0432	Pfam Uncharacterised protein family UPF0047
CYG48_RS09045	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CYG48_RS09050	COG0358	DNA primase activity
CYG48_RS09060	COG0505	Belongs to the CarA family
CYG48_RS09065	COG0534	Mate efflux family protein
CYG48_RS09075	COG2321	neutral zinc metallopeptidase
CYG48_RS09080	COG2223	nitrite transmembrane transporter activity
CYG48_RS09085	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CYG48_RS09105	COG1573	uracil-dna glycosylase
CYG48_RS09115	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CYG48_RS09120	COG0438	transferase activity, transferring glycosyl groups
CYG48_RS09125	COG0438	transferase activity, transferring glycosyl groups
CYG48_RS09135	COG1522	sequence-specific DNA binding
CYG48_RS09140	COG0492	ferredoxin-NADP+ reductase activity
CYG48_RS09145	COG0583	DNA-binding transcription factor activity
CYG48_RS09150	COG0640	Transcriptional regulator
CYG48_RS09155	COG1902	pentaerythritol trinitrate reductase activity
CYG48_RS09165	COG0583	DNA-binding transcription factor activity
CYG48_RS09175	COG0387	Pfam Sodium calcium exchanger
CYG48_RS09180	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CYG48_RS09185	COG2133	pyrroloquinoline quinone binding
CYG48_RS09195	COG1278	Cold shock
CYG48_RS09200	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CYG48_RS09210	COG1846	Transcriptional regulator
CYG48_RS09215	COG0745	RESPONSE REGULATOR receiver
CYG48_RS09220	COG2205	protein histidine kinase activity
CYG48_RS09225	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CYG48_RS09245	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CYG48_RS09255	COG1496	oxidoreductase activity
CYG48_RS09270	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CYG48_RS09280	COG5001	Diguanylate cyclase
CYG48_RS09280	COG3300	MHYT domain
CYG48_RS09290	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CYG48_RS09295	COG3300	MHYT domain
CYG48_RS09295	COG5001	Diguanylate cyclase
CYG48_RS09300	COG0193	aminoacyl-tRNA hydrolase activity
CYG48_RS09305	COG2890	protein-(glutamine-N5) methyltransferase activity
CYG48_RS09310	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CYG48_RS09335	COG2857	Cytochrome c1
CYG48_RS09335	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CYG48_RS09355	COG1132	(ABC) transporter
CYG48_RS09360	COG1132	(ABC) transporter
CYG48_RS09365	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CYG48_RS09380	COG0408	coproporphyrinogen oxidase activity
CYG48_RS09395	COG0617	tRNA 3'-terminal CCA addition
CYG48_RS09410	COG0714	Associated with various cellular activities
CYG48_RS09430	COG0454	-acetyltransferase
CYG48_RS09435	COG0454	-acetyltransferase
CYG48_RS09440	COG0477	Major facilitator Superfamily
CYG48_RS09450	COG0435	Glutathione S-transferase
CYG48_RS09480	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CYG48_RS09485	COG3135	benzoate transporter
CYG48_RS09490	COG5001	Diguanylate cyclase
CYG48_RS09490	COG3300	MHYT domain
CYG48_RS09495	COG0740	serine-type endopeptidase activity
CYG48_RS09505	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CYG48_RS09510	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CYG48_RS09525	COG0512	Glutamine amidotransferase of anthranilate synthase
CYG48_RS09525	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CYG48_RS09535	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CYG48_RS09540	COG2197	response regulator
CYG48_RS09565	COG1435	thymidine kinase activity
CYG48_RS09580	COG4175	Glycine betaine
CYG48_RS09595	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CYG48_RS09600	COG1132	(ABC) transporter
CYG48_RS09610	COG1846	Transcriptional regulator
CYG48_RS09620	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CYG48_RS09625	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
CYG48_RS09640	COG2207	Transcriptional regulator
CYG48_RS09645	COG0640	Transcriptional regulator
CYG48_RS09660	COG0366	Alpha amylase catalytic
CYG48_RS09665	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CYG48_RS09670	COG1160	GTP binding
CYG48_RS09685	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
CYG48_RS09700	COG0024	Methionine aminopeptidase
CYG48_RS09715	COG3920	Histidine kinase
CYG48_RS09725	COG4941	Belongs to the sigma-70 factor family
CYG48_RS09730	COG3795	YCII-related domain
CYG48_RS09735	COG0625	glutathione transferase activity
CYG48_RS09745	COG1686	Belongs to the peptidase S11 family
CYG48_RS09750	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CYG48_RS09755	COG1028	Short-chain dehydrogenase reductase Sdr
CYG48_RS09765	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CYG48_RS09780	COG2852	Protein conserved in bacteria
CYG48_RS09800	COG0583	DNA-binding transcription factor activity
CYG48_RS09810	COG0583	DNA-binding transcription factor activity
CYG48_RS09825	COG0402	S-adenosylhomocysteine deaminase activity
CYG48_RS09845	COG0693	protein deglycase activity
CYG48_RS09865	COG1522	sequence-specific DNA binding
CYG48_RS09885	COG2351	hydroxyisourate hydrolase activity
CYG48_RS09890	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
CYG48_RS09905	COG4266	Belongs to the allantoicase family
CYG48_RS09920	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CYG48_RS09925	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CYG48_RS09925	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
CYG48_RS09940	COG5002	protein histidine kinase activity
CYG48_RS09940	COG2205	protein histidine kinase activity
CYG48_RS09940	COG0784	Response regulator, receiver
CYG48_RS09950	COG0513	Belongs to the DEAD box helicase family
CYG48_RS09965	COG2308	Evidence 4 Homologs of previously reported genes of
CYG48_RS09975	COG1305	Transglutaminase-like
CYG48_RS10025	COG2346	COG2346, Truncated hemoglobins
CYG48_RS10045	COG0493	'glutamate synthase
CYG48_RS10065	COG0583	DNA-binding transcription factor activity
CYG48_RS10070	COG2855	membrane
CYG48_RS10080	COG0174	glutamine synthetase
CYG48_RS10085	COG1309	transcriptional regulator
CYG48_RS10115	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CYG48_RS10120	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CYG48_RS10140	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CYG48_RS10150	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CYG48_RS10155	COG0830	nickel cation binding
CYG48_RS10160	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
CYG48_RS10165	COG0804	urea catabolic process
CYG48_RS10170	COG3755	Protein conserved in bacteria
CYG48_RS10175	COG0832	Belongs to the urease beta subunit family
CYG48_RS10180	COG0831	urea catabolic process
CYG48_RS10185	COG0829	nickel cation binding
CYG48_RS10205	COG0683	leucine binding
CYG48_RS10295	COG0564	pseudouridine synthase activity
CYG48_RS10300	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CYG48_RS10310	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CYG48_RS10335	COG0346	lactoylglutathione lyase activity
CYG48_RS10340	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CYG48_RS10355	COG2832	Protein of unknown function (DUF454)
CYG48_RS10405	COG1960	acyl-CoA dehydrogenase activity
CYG48_RS10410	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CYG48_RS10420	COG1252	NADH dehydrogenase
CYG48_RS10475	COG2111	Na H antiporter
CYG48_RS10475	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CYG48_RS10480	COG1006	Multisubunit Na H antiporter MnhC subunit
CYG48_RS10485	COG0651	ATP synthesis coupled electron transport
CYG48_RS10490	COG1863	multisubunit Na H antiporter MnhE subunit
CYG48_RS10495	COG2212	antiporter activity
CYG48_RS10500	COG1320	monovalent cation:proton antiporter activity
CYG48_RS10530	COG0482	sulfurtransferase activity
CYG48_RS10545	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CYG48_RS10560	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CYG48_RS10595	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CYG48_RS10600	COG0037	tRNA processing
CYG48_RS10610	COG2885	chlorophyll binding
CYG48_RS10615	COG0823	Involved in the tonB-independent uptake of proteins
CYG48_RS10625	COG0848	biopolymer transport protein
CYG48_RS10635	COG0824	Thioesterase
CYG48_RS10645	COG1408	metallophosphoesterase
CYG48_RS10650	COG2255	four-way junction helicase activity
CYG48_RS10655	COG0632	four-way junction helicase activity
CYG48_RS10670	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CYG48_RS10680	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CYG48_RS10685	COG0217	transcriptional regulatory protein
CYG48_RS10705	COG1692	metallophosphoesterase
CYG48_RS10715	COG1253	flavin adenine dinucleotide binding
CYG48_RS10720	COG3920	Histidine kinase
CYG48_RS10725	COG0784	Response regulator, receiver
CYG48_RS10770	COG0126	phosphoglycerate kinase activity
CYG48_RS10775	COG3588	fructose-bisphosphate aldolase
CYG48_RS10805	COG0254	rRNA binding
CYG48_RS10810	COG1132	(ABC) transporter
CYG48_RS10835	COG0483	inositol monophosphate 1-phosphatase activity
CYG48_RS10850	COG0352	thiamine-phosphate diphosphorylase activity
CYG48_RS10860	COG0640	Transcriptional regulator
CYG48_RS10875	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CYG48_RS10880	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CYG48_RS10885	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CYG48_RS10890	COG0457	Tetratricopeptide repeat
CYG48_RS10895	COG0596	Alpha beta hydrolase
CYG48_RS10900	COG0469	pyruvate kinase activity
CYG48_RS10920	COG3750	Belongs to the UPF0335 family
CYG48_RS10945	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CYG48_RS10945	COG0512	Glutamine amidotransferase of anthranilate synthase
CYG48_RS10955	COG5310	Homospermidine synthase
CYG48_RS10965	COG0737	Belongs to the 5'-nucleotidase family
CYG48_RS10970	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CYG48_RS10980	COG0330	HflC and HflK could
CYG48_RS11000	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CYG48_RS11005	COG2951	lytic endotransglycosylase activity
CYG48_RS11020	COG0070	glutamate synthase
CYG48_RS11020	COG0067	glutamate synthase
CYG48_RS11020	COG0069	glutamate synthase activity
CYG48_RS11045	COG0071	Belongs to the small heat shock protein (HSP20) family
CYG48_RS11105	COG1121	(ABC) transporter
CYG48_RS11115	COG2308	Evidence 4 Homologs of previously reported genes of
CYG48_RS11115	COG2307	Protein conserved in bacteria
CYG48_RS11130	COG0058	SHG alpha-glucan phosphorylase activity
CYG48_RS11135	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CYG48_RS11140	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CYG48_RS11145	COG0297	glycogen (starch) synthase activity
CYG48_RS11150	COG0033	Phosphoglucomutase
CYG48_RS11170	COG0446	pyridine nucleotide-disulphide oxidoreductase
CYG48_RS11170	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CYG48_RS11180	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CYG48_RS11195	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CYG48_RS11240	COG5001	Diguanylate cyclase
CYG48_RS11255	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CYG48_RS11260	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CYG48_RS11265	COG1609	Transcriptional regulator
CYG48_RS11270	COG1846	Transcriptional regulator
CYG48_RS11285	COG3742	Toxic component of a toxin-antitoxin (TA) module. An RNase
CYG48_RS11290	COG0523	cobalamin synthesis protein
CYG48_RS11315	COG0583	DNA-binding transcription factor activity
CYG48_RS11320	COG1028	Short-chain dehydrogenase reductase Sdr
CYG48_RS11340	COG0583	DNA-binding transcription factor activity
CYG48_RS11350	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
CYG48_RS11355	COG0583	DNA-binding transcription factor activity
CYG48_RS11360	COG0667	Aldo Keto reductase
CYG48_RS11380	COG0800	Aldolase
CYG48_RS11385	COG2954	triphosphatase activity
CYG48_RS11395	COG1054	Belongs to the UPF0176 family
CYG48_RS11400	COG3300	MHYT domain
CYG48_RS11400	COG5001	Diguanylate cyclase
CYG48_RS11410	COG2011	ABC-type metal ion transport system permease component
CYG48_RS11415	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CYG48_RS11425	COG0673	inositol 2-dehydrogenase activity
CYG48_RS11430	COG0110	maltose O-acetyltransferase activity
CYG48_RS11440	COG1879	ABC-type sugar transport system periplasmic component
CYG48_RS11445	COG1172	Belongs to the binding-protein-dependent transport system permease family
CYG48_RS11450	COG1129	ABC transporter
CYG48_RS11455	COG2115	Belongs to the xylose isomerase family
CYG48_RS11460	COG1070	Carbohydrate kinase
CYG48_RS11465	COG1609	Transcriptional regulator
CYG48_RS11480	COG1309	transcriptional regulator
CYG48_RS11485	COG1253	flavin adenine dinucleotide binding
CYG48_RS11490	COG0471	metal ion transport
CYG48_RS11490	COG3273	potassium ion transport
CYG48_RS11495	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CYG48_RS11500	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CYG48_RS11510	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CYG48_RS11520	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CYG48_RS11555	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CYG48_RS11560	COG0154	amidase activity
CYG48_RS11585	COG0784	Response regulator, receiver
CYG48_RS11595	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CYG48_RS11600	COG0601	transmembrane transport
CYG48_RS11610	COG1473	amidohydrolase
CYG48_RS11615	COG4172	Belongs to the ABC transporter superfamily
CYG48_RS11620	COG2390	Transcriptional regulator
CYG48_RS11630	COG1175	transmembrane transport
CYG48_RS11635	COG0395	ABC-type sugar transport system, permease component
CYG48_RS11670	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CYG48_RS11675	COG0601	transmembrane transport
CYG48_RS11710	COG1176	ABC-type spermidine putrescine transport system, permease component I
CYG48_RS11725	COG0154	amidase activity
CYG48_RS11730	COG0583	DNA-binding transcription factor activity
CYG48_RS11735	COG1960	acyl-CoA dehydrogenase activity
CYG48_RS11745	COG4335	DNA alkylation repair
CYG48_RS11750	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CYG48_RS11755	COG4208	sulfate ABC transporter
CYG48_RS11760	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
CYG48_RS11775	COG1024	Enoyl-CoA hydratase
CYG48_RS11790	COG0559	Belongs to the binding-protein-dependent transport system permease family
CYG48_RS11830	COG4993	Dehydrogenase
CYG48_RS11860	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
CYG48_RS11870	COG3685	Protein conserved in bacteria
CYG48_RS11885	COG0297	glycogen (starch) synthase activity
CYG48_RS11925	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CYG48_RS11930	COG2010	Cytochrome c
CYG48_RS11930	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CYG48_RS11940	COG0693	protein deglycase activity
CYG48_RS11950	COG3920	Histidine kinase
CYG48_RS11950	COG2202	Pas domain
CYG48_RS11960	COG3842	ATPase activity
CYG48_RS11965	COG0395	ABC-type sugar transport system, permease component
CYG48_RS11970	COG1175	transmembrane transport
CYG48_RS11980	COG1609	Transcriptional regulator
CYG48_RS12015	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CYG48_RS12020	COG0367	asparagine synthase
CYG48_RS12040	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CYG48_RS12045	COG0392	lysyltransferase activity
CYG48_RS12110	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CYG48_RS12115	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CYG48_RS12120	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
CYG48_RS12125	COG2080	2 iron, 2 sulfur cluster binding
CYG48_RS12130	COG1309	transcriptional regulator
CYG48_RS12135	COG1072	(Pantothenic acid kinase))
CYG48_RS12140	COG1501	Belongs to the glycosyl hydrolase 31 family
CYG48_RS12145	COG2188	Transcriptional regulator
CYG48_RS12150	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CYG48_RS12155	COG4989	oxidoreductase activity
CYG48_RS12175	COG3707	response regulator
CYG48_RS12180	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CYG48_RS12185	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CYG48_RS12190	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CYG48_RS12195	COG1116	anion transmembrane transporter activity
CYG48_RS12200	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CYG48_RS12205	COG2146	nitrite reductase [NAD(P)H] activity
CYG48_RS12210	COG0243	molybdopterin cofactor binding
CYG48_RS12240	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CYG48_RS12245	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CYG48_RS12260	COG1304	FMN binding
CYG48_RS12270	COG1562	ergosterol biosynthetic process
CYG48_RS12285	COG0673	inositol 2-dehydrogenase activity
CYG48_RS12300	COG3842	ATPase activity
CYG48_RS12305	COG0395	ABC-type sugar transport system, permease component
CYG48_RS12310	COG1175	transmembrane transport
CYG48_RS12315	COG1653	transport
CYG48_RS12325	COG1285	pathogenesis
CYG48_RS12340	COG3292	Two component regulator propeller
CYG48_RS12340	COG2205	protein histidine kinase activity
CYG48_RS12340	COG0745	RESPONSE REGULATOR receiver
CYG48_RS12350	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CYG48_RS12370	COG0179	Fumarylacetoacetate (FAA) hydrolase
CYG48_RS12375	COG3971	2-oxopent-4-enoate hydratase activity
CYG48_RS12380	COG3961	Belongs to the TPP enzyme family
CYG48_RS12455	COG1063	alcohol dehydrogenase
CYG48_RS12495	COG1196	nuclear chromosome segregation
CYG48_RS12495	COG0741	lytic transglycosylase activity
CYG48_RS12495	COG0739	heme binding
CYG48_RS12500	COG0542	response to heat
CYG48_RS12510	COG2890	protein-(glutamine-N5) methyltransferase activity
CYG48_RS12515	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CYG48_RS12520	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CYG48_RS12525	COG0527	aspartate kinase activity
CYG48_RS12535	COG1609	Transcriptional regulator
CYG48_RS12540	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
CYG48_RS12545	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
CYG48_RS12560	COG1175	transmembrane transport
CYG48_RS12565	COG0395	ABC-type sugar transport system, permease component
CYG48_RS12570	COG3842	ATPase activity
CYG48_RS12590	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CYG48_RS12600	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CYG48_RS12605	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CYG48_RS12615	COG2226	methyltransferase
CYG48_RS12630	COG0494	nUDIX hydrolase
CYG48_RS12640	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CYG48_RS12645	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CYG48_RS12650	COG0653	protein targeting
CYG48_RS12665	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CYG48_RS12795	COG3179	chitinase
CYG48_RS12840	COG3239	Fatty acid desaturase
CYG48_RS12920	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CYG48_RS12925	COG1295	ribonuclease BN
CYG48_RS12930	COG0300	oxidoreductase activity
CYG48_RS12940	COG2096	Adenosyltransferase
CYG48_RS12950	COG2086	electron transfer activity
CYG48_RS12960	COG1250	3-hydroxyacyl-CoA dehydrogenase
CYG48_RS12965	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CYG48_RS12970	COG0165	Argininosuccinate lyase
CYG48_RS13005	COG2884	Cell division ATP-binding protein ftsE
CYG48_RS13025	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
CYG48_RS13035	COG0287	Prephenate dehydrogenase
CYG48_RS13040	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CYG48_RS13045	COG2226	methyltransferase
CYG48_RS13050	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CYG48_RS13070	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CYG48_RS13075	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
CYG48_RS13105	COG4536	flavin adenine dinucleotide binding
CYG48_RS13110	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CYG48_RS13115	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CYG48_RS13125	COG4974	Belongs to the 'phage' integrase family
CYG48_RS13130	COG0825	malonyl-CoA metabolic process
CYG48_RS13135	COG3034	peptidoglycan biosynthetic process
CYG48_RS13145	COG0523	cobalamin synthesis protein
CYG48_RS13150	COG1686	Belongs to the peptidase S11 family
CYG48_RS13155	COG1473	amidohydrolase
CYG48_RS13185	COG0640	Transcriptional regulator
CYG48_RS13195	COG0431	NADPH-dependent FMN reductase
CYG48_RS13205	COG0798	PFAM Bile acid sodium symporter
CYG48_RS13245	COG0346	lactoylglutathione lyase activity
CYG48_RS13360	COG2963	transposase activity
CYG48_RS13365	COG3436	PFAM IS66 Orf2 family protein
CYG48_RS13370	COG4372	Transposase
CYG48_RS13385	COG3727	T/G mismatch-specific endonuclease activity
CYG48_RS13400	COG0270	DNA (cytosine-5-)-methyltransferase activity
CYG48_RS13405	COG0587	DNA-directed DNA polymerase activity
CYG48_RS13435	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CYG48_RS13450	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CYG48_RS13455	COG0156	8-amino-7-oxononanoate synthase activity
CYG48_RS13480	COG0729	surface antigen
CYG48_RS13490	COG0010	Belongs to the arginase family
CYG48_RS13495	COG0835	chemotaxis
CYG48_RS13505	COG2223	nitrite transmembrane transporter activity
CYG48_RS13515	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CYG48_RS13520	COG3383	formate dehydrogenase (NAD+) activity
CYG48_RS13535	COG0583	DNA-binding transcription factor activity
CYG48_RS13540	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CYG48_RS13545	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CYG48_RS13550	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CYG48_RS13555	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CYG48_RS13560	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CYG48_RS13585	COG4974	Belongs to the 'phage' integrase family
CYG48_RS13610	COG1028	Short-chain dehydrogenase reductase Sdr
CYG48_RS13625	COG0508	dehydrogenase complex catalyzes the overall conversion of
CYG48_RS13640	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CYG48_RS13645	COG0045	succinate-CoA ligase (ADP-forming) activity
CYG48_RS13650	COG0039	L-malate dehydrogenase activity
CYG48_RS13655	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
CYG48_RS13690	COG2264	protein methyltransferase activity
CYG48_RS13705	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CYG48_RS13710	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CYG48_RS13715	COG0181	hydroxymethylbilane synthase activity
CYG48_RS13750	COG1872	DUF167
CYG48_RS13755	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CYG48_RS13760	COG1247	-acetyltransferase
CYG48_RS13765	COG1217	gtp-binding protein TYPA
CYG48_RS13770	COG0339	signal peptide processing
CYG48_RS13790	COG0477	Major facilitator Superfamily
CYG48_RS13795	COG0137	argininosuccinate synthase activity
CYG48_RS13815	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
CYG48_RS13820	COG4120	Belongs to the binding-protein-dependent transport system permease family
CYG48_RS13830	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CYG48_RS13840	COG1595	DNA-templated transcription, initiation
CYG48_RS13850	COG2154	pterin-4-alpha-carbinolamine dehydratase
CYG48_RS13855	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
CYG48_RS13865	COG4181	ATPase activity
CYG48_RS13875	COG0670	Belongs to the BI1 family
CYG48_RS13900	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CYG48_RS13905	COG4133	protoheme IX ABC transporter activity
CYG48_RS13910	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CYG48_RS13915	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CYG48_RS13935	COG2917	probably involved in intracellular septation
CYG48_RS13940	COG0552	protein localization to endoplasmic reticulum
CYG48_RS13945	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CYG48_RS13950	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CYG48_RS13965	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CYG48_RS13970	COG1605	Chorismate mutase
CYG48_RS13970	COG0287	Prephenate dehydrogenase
CYG48_RS13975	COG0228	four-way junction DNA binding
CYG48_RS13980	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CYG48_RS13985	COG0336	Belongs to the RNA methyltransferase TrmD family
CYG48_RS13995	COG0335	large ribosomal subunit rRNA binding
CYG48_RS14005	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CYG48_RS14030	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CYG48_RS14035	COG1674	ftsk spoiiie
CYG48_RS14040	COG0004	ammonium transporteR
CYG48_RS14045	COG0347	Belongs to the P(II) protein family
CYG48_RS14050	COG1946	Acyl-CoA thioesterase
CYG48_RS14055	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CYG48_RS14060	COG2835	tetraacyldisaccharide 4'-kinase activity
CYG48_RS14070	COG3118	belongs to the thioredoxin family
CYG48_RS14095	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
CYG48_RS14110	COG0488	(ABC) transporter
CYG48_RS14135	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
CYG48_RS14150	COG1329	Transcriptional regulator
CYG48_RS14155	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CYG48_RS14160	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CYG48_RS14180	COG1028	Short-chain dehydrogenase reductase Sdr
CYG48_RS14185	COG0183	Belongs to the thiolase family
CYG48_RS14190	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
CYG48_RS14195	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CYG48_RS14200	COG0625	glutathione transferase activity
CYG48_RS14205	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CYG48_RS14210	COG0142	geranyltranstransferase activity
CYG48_RS14220	COG2885	chlorophyll binding
CYG48_RS14225	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CYG48_RS14230	COG2223	nitrite transmembrane transporter activity
CYG48_RS14235	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CYG48_RS14240	COG2197	response regulator
CYG48_RS14245	COG1132	(ABC) transporter
CYG48_RS14250	COG3459	Glycosyltransferase 36 associated
CYG48_RS14265	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CYG48_RS14270	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CYG48_RS14275	COG1473	amidohydrolase
CYG48_RS14280	COG0747	negative chemotaxis
CYG48_RS14285	COG0601	transmembrane transport
CYG48_RS14290	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CYG48_RS14295	COG0444	Belongs to the ABC transporter superfamily
CYG48_RS14300	COG4608	Belongs to the ABC transporter superfamily
CYG48_RS14305	COG4953	penicillin-binding protein 1C
CYG48_RS14310	COG2373	Large extracellular alpha-helical protein
CYG48_RS14315	COG1028	Short-chain dehydrogenase reductase Sdr
CYG48_RS14325	COG0183	Belongs to the thiolase family
CYG48_RS14335	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CYG48_RS14340	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CYG48_RS14340	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CYG48_RS14355	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CYG48_RS14360	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CYG48_RS14365	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CYG48_RS14385	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CYG48_RS14390	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CYG48_RS14400	COG0861	Integral membrane protein TerC family
CYG48_RS14415	COG0765	amino acid transport
CYG48_RS14420	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
CYG48_RS14425	COG1233	COG1233 Phytoene dehydrogenase and related
CYG48_RS14450	COG1028	Short-chain dehydrogenase reductase Sdr
CYG48_RS14455	COG1024	Enoyl-CoA hydratase
CYG48_RS14470	COG0251	oxidation-reduction process
CYG48_RS14475	COG1024	Enoyl-CoA hydratase
CYG48_RS14475	COG1250	3-hydroxyacyl-CoA dehydrogenase
CYG48_RS14480	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CYG48_RS14490	COG1082	Xylose isomerase domain protein TIM barrel
CYG48_RS14495	COG1879	ABC-type sugar transport system periplasmic component
CYG48_RS14500	COG1172	Belongs to the binding-protein-dependent transport system permease family
CYG48_RS14540	COG3483	tryptophan 2,3-dioxygenase activity
CYG48_RS14590	COG1278	Cold shock
CYG48_RS14600	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
CYG48_RS14605	COG0071	Belongs to the small heat shock protein (HSP20) family
CYG48_RS14615	COG0459	protein refolding
CYG48_RS14620	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CYG48_RS14655	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CYG48_RS14660	COG1309	transcriptional regulator
CYG48_RS14665	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CYG48_RS14670	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CYG48_RS14680	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CYG48_RS14690	COG1509	lysine 2,3-aminomutase activity
CYG48_RS14695	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
CYG48_RS14715	COG0583	DNA-binding transcription factor activity
CYG48_RS14720	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CYG48_RS14725	COG1012	belongs to the aldehyde dehydrogenase family
CYG48_RS14780	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CYG48_RS14785	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CYG48_RS14790	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CYG48_RS14800	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CYG48_RS14805	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CYG48_RS14810	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CYG48_RS14815	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CYG48_RS14820	COG0799	negative regulation of ribosome biogenesis
CYG48_RS14825	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CYG48_RS14835	COG0793	Belongs to the peptidase S41A family
CYG48_RS14845	COG0494	nUDIX hydrolase
CYG48_RS14860	COG0587	DNA-directed DNA polymerase activity
CYG48_RS14880	COG2301	Belongs to the HpcH HpaI aldolase family
CYG48_RS14890	COG0066	3-isopropylmalate dehydratase activity
CYG48_RS14895	COG0251	oxidation-reduction process
CYG48_RS14900	COG0473	3-isopropylmalate dehydrogenase activity
CYG48_RS14905	COG0671	phosphoesterase, PA-phosphatase related
CYG48_RS14910	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CYG48_RS14920	COG0288	reversible hydration of carbon dioxide
CYG48_RS14925	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
CYG48_RS14930	COG2902	Dehydrogenase
CYG48_RS14935	COG2270	Major facilitator Superfamily
CYG48_RS14940	COG0138	bifunctional purine biosynthesis protein purh
CYG48_RS14950	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CYG48_RS14955	COG0501	Belongs to the peptidase M48B family
CYG48_RS14970	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CYG48_RS14985	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CYG48_RS14990	COG0495	leucyl-tRNA aminoacylation
CYG48_RS15015	COG0357	Ribosomal RNA small subunit methyltransferase G
CYG48_RS15020	COG0445	tRNA wobble uridine modification
CYG48_RS15025	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CYG48_RS15030	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CYG48_RS15035	COG1981	membrane
CYG48_RS15040	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CYG48_RS15045	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CYG48_RS15050	COG0424	maF-like protein
CYG48_RS15055	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CYG48_RS15060	COG0237	dephospho-CoA kinase activity
CYG48_RS15070	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
CYG48_RS15075	COG3030	protein affecting phage T7 exclusion by the F plasmid
CYG48_RS15130	COG0135	phosphoribosylanthranilate isomerase activity
CYG48_RS15135	COG0133	tryptophan synthase activity
CYG48_RS15140	COG0159	tryptophan synthase activity
CYG48_RS15145	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CYG48_RS15170	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CYG48_RS15175	COG0802	atpase or kinase
CYG48_RS15180	COG2205	protein histidine kinase activity
CYG48_RS15185	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CYG48_RS15190	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CYG48_RS15195	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
CYG48_RS15195	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CYG48_RS15205	COG0642	Histidine kinase
CYG48_RS15210	COG0745	RESPONSE REGULATOR receiver
CYG48_RS15215	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
CYG48_RS15230	COG1072	(Pantothenic acid kinase))
CYG48_RS15235	COG0140	phosphoribosyl-ATP diphosphatase activity
CYG48_RS15240	COG0107	imidazoleglycerol-phosphate synthase activity
CYG48_RS15245	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CYG48_RS15250	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CYG48_RS15260	COG0131	Imidazoleglycerol-phosphate dehydratase
CYG48_RS15265	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CYG48_RS15275	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CYG48_RS15285	COG2124	cytochrome p450
CYG48_RS15295	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CYG48_RS15310	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
CYG48_RS15320	COG1643	Atp-dependent helicase
CYG48_RS15325	COG2423	ornithine cyclodeaminase activity
CYG48_RS15365	COG1454	alcohol dehydrogenase
CYG48_RS15370	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CYG48_RS15380	COG4770	biotin carboxylase activity
CYG48_RS15385	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CYG48_RS15385	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CYG48_RS15400	COG1024	Enoyl-CoA hydratase
CYG48_RS15415	COG1960	acyl-CoA dehydrogenase activity
CYG48_RS15420	COG1192	Involved in chromosome partitioning
CYG48_RS15425	COG2201	protein-glutamate methylesterase activity
CYG48_RS15435	COG0835	chemotaxis
CYG48_RS15445	COG0835	chemotaxis
CYG48_RS15455	COG0745	RESPONSE REGULATOR receiver
CYG48_RS15475	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CYG48_RS15480	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CYG48_RS15485	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CYG48_RS15490	COG1185	polyribonucleotide nucleotidyltransferase activity
CYG48_RS15495	COG2813	Specifically methylates the guanine in position
CYG48_RS15500	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CYG48_RS15510	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CYG48_RS15595	COG1129	ABC transporter
CYG48_RS15605	COG1846	Transcriptional regulator
CYG48_RS15610	COG2066	Belongs to the glutaminase family
CYG48_RS15640	COG0745	RESPONSE REGULATOR receiver
CYG48_RS15650	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CYG48_RS15655	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CYG48_RS15660	COG2188	Transcriptional regulator
CYG48_RS15665	COG2971	BadF BadG BcrA BcrD
CYG48_RS15670	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CYG48_RS15680	COG1175	transmembrane transport
CYG48_RS15685	COG0395	ABC-type sugar transport system, permease component
CYG48_RS15690	COG0673	inositol 2-dehydrogenase activity
CYG48_RS15720	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CYG48_RS15725	COG0539	negative regulation of cytoplasmic translation
CYG48_RS15745	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
CYG48_RS15755	COG0848	biopolymer transport protein
CYG48_RS15765	COG1028	Short-chain dehydrogenase reductase Sdr
CYG48_RS15770	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CYG48_RS15770	COG3064	Membrane
CYG48_RS15780	COG0195	Participates in both transcription termination and antitermination
CYG48_RS15780	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CYG48_RS15785	COG0779	Required for maturation of 30S ribosomal subunits
CYG48_RS15800	COG2951	lytic endotransglycosylase activity
CYG48_RS15805	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CYG48_RS15820	COG1309	transcriptional regulator
CYG48_RS15830	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CYG48_RS15835	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CYG48_RS15850	COG2816	NAD+ diphosphatase activity
CYG48_RS15855	COG1605	Chorismate mutase
CYG48_RS15855	COG0077	Prephenate dehydratase
CYG48_RS15860	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CYG48_RS15865	COG3474	cytochrome
CYG48_RS15875	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CYG48_RS15890	COG0456	acetyltransferase
CYG48_RS15900	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CYG48_RS15905	COG0840	transmembrane signaling receptor activity
CYG48_RS15910	COG2900	Belongs to the SlyX family
CYG48_RS15915	COG0484	heat shock protein binding
CYG48_RS15920	COG0443	Heat shock 70 kDa protein
CYG48_RS15925	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CYG48_RS15960	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CYG48_RS15965	COG1278	Cold shock
CYG48_RS15970	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CYG48_RS15980	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CYG48_RS15980	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CYG48_RS15990	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
CYG48_RS15995	COG3454	Phosphonate metabolism
CYG48_RS16000	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
CYG48_RS16005	COG0588	phosphoglycerate mutase activity
CYG48_RS16010	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CYG48_RS16015	COG0837	glucose binding
CYG48_RS16020	COG1803	Methylglyoxal synthase
CYG48_RS16025	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
CYG48_RS16030	COG4166	transmembrane transport
CYG48_RS16035	COG4174	ABC transporter (Permease)
CYG48_RS16040	COG4239	(ABC) transporter, permease
CYG48_RS16045	COG4172	Belongs to the ABC transporter superfamily
CYG48_RS16060	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CYG48_RS16075	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CYG48_RS16110	COG4964	Belongs to the GSP D family
CYG48_RS16145	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
CYG48_RS16150	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CYG48_RS16155	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CYG48_RS16165	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
CYG48_RS16170	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CYG48_RS16175	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
CYG48_RS16185	COG1079	Belongs to the binding-protein-dependent transport system permease family
CYG48_RS16190	COG1079	Belongs to the binding-protein-dependent transport system permease family
CYG48_RS16195	COG3845	ABC transporter
CYG48_RS16200	COG1744	ABC transporter substrate-binding protein PnrA-like
CYG48_RS16220	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CYG48_RS16230	COG0791	NLP P60 protein
CYG48_RS16240	COG0481	GTPase activity
CYG48_RS16265	COG2814	Major facilitator Superfamily
CYG48_RS16270	COG1309	transcriptional regulator
CYG48_RS16285	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CYG48_RS16295	COG1278	Cold shock
CYG48_RS16305	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CYG48_RS16310	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CYG48_RS16335	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CYG48_RS16340	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CYG48_RS16345	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CYG48_RS16350	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CYG48_RS16355	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CYG48_RS16355	COG0072	phenylalanine-tRNA ligase activity
CYG48_RS16370	COG0667	Aldo Keto reductase
CYG48_RS16375	COG0667	Aldo Keto reductase
CYG48_RS16390	COG1393	Belongs to the ArsC family
CYG48_RS16395	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CYG48_RS16405	COG2309	aminopeptidase activity
CYG48_RS16410	COG1570	exodeoxyribonuclease VII activity
CYG48_RS16420	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CYG48_RS16420	COG0519	Catalyzes the synthesis of GMP from XMP
CYG48_RS16435	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
CYG48_RS16445	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CYG48_RS16455	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CYG48_RS16465	COG1968	undecaprenyl-diphosphatase activity
CYG48_RS16485	COG0284	orotidine-5'-phosphate decarboxylase activity
CYG48_RS16495	COG3963	phosphatidate phosphatase activity
CYG48_RS16505	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CYG48_RS16510	COG0792	nuclease activity
CYG48_RS16515	COG0189	ligase activity
CYG48_RS16530	COG0756	dUTP diphosphatase activity
CYG48_RS16535	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CYG48_RS16545	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CYG48_RS16550	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
CYG48_RS16555	COG1877	trehalose-phosphatase activity
CYG48_RS16565	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CYG48_RS16570	COG2814	Major facilitator Superfamily
CYG48_RS16585	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CYG48_RS16590	COG2226	methyltransferase
CYG48_RS16595	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CYG48_RS16600	COG1024	Enoyl-CoA hydratase
CYG48_RS16605	COG0268	Binds directly to 16S ribosomal RNA
CYG48_RS16625	COG3976	FMN-binding domain protein
CYG48_RS16625	COG1053	succinate dehydrogenase
CYG48_RS16625	COG0431	NADPH-dependent FMN reductase
CYG48_RS16660	COG0066	3-isopropylmalate dehydratase activity
CYG48_RS16665	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CYG48_RS16700	COG1846	Transcriptional regulator
CYG48_RS16710	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CYG48_RS16715	COG0835	chemotaxis
CYG48_RS16720	COG0840	transmembrane signaling receptor activity
CYG48_RS16725	COG0835	chemotaxis
CYG48_RS16730	COG0643	Histidine kinase
CYG48_RS16730	COG2198	Histidine kinase
CYG48_RS16735	COG0745	RESPONSE REGULATOR receiver
CYG48_RS16760	COG0395	ABC-type sugar transport system, permease component
CYG48_RS16770	COG0445	tRNA wobble uridine modification
CYG48_RS16775	COG3842	ATPase activity
CYG48_RS16790	COG2176	DNA-directed DNA polymerase activity
CYG48_RS16790	COG5002	protein histidine kinase activity
CYG48_RS16800	COG0517	IMP dehydrogenase activity
CYG48_RS16800	COG1125	glycine betaine transport
CYG48_RS16805	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CYG48_RS16815	COG0385	Bile acid
CYG48_RS16820	COG1115	amino acid carrier protein
CYG48_RS16830	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CYG48_RS16835	COG3307	-O-antigen
CYG48_RS16840	COG1596	polysaccharide export
CYG48_RS16845	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CYG48_RS16855	COG1215	transferase activity, transferring glycosyl groups
CYG48_RS16860	COG2327	Polysaccharide pyruvyl transferase
CYG48_RS16865	COG0463	Glycosyl transferase, family 2
CYG48_RS16870	COG2244	polysaccharide biosynthetic process
CYG48_RS16875	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CYG48_RS16880	COG2273	Hydrolase Family 16
CYG48_RS16890	COG1215	transferase activity, transferring glycosyl groups
CYG48_RS16895	COG1215	transferase activity, transferring glycosyl groups
CYG48_RS16900	COG0489	protein tyrosine kinase activity
CYG48_RS16900	COG3206	protein involved in exopolysaccharide biosynthesis
CYG48_RS16905	COG0840	transmembrane signaling receptor activity
CYG48_RS16945	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CYG48_RS16950	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CYG48_RS16960	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CYG48_RS16965	COG4605	iron ion homeostasis
CYG48_RS16970	COG4604	ABC transporter, ATP-binding protein
CYG48_RS16980	COG4771	TonB-dependent receptor
CYG48_RS17000	COG0765	amino acid transport
CYG48_RS17005	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CYG48_RS17010	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CYG48_RS17015	COG0583	DNA-binding transcription factor activity
CYG48_RS17055	COG1309	transcriptional regulator
CYG48_RS17085	COG1454	alcohol dehydrogenase
CYG48_RS17095	COG0657	acetylesterase activity
CYG48_RS17105	COG0300	oxidoreductase activity
CYG48_RS17115	COG0583	DNA-binding transcription factor activity
CYG48_RS17120	COG0251	oxidation-reduction process
CYG48_RS17125	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CYG48_RS17130	COG0246	Mannitol dehydrogenase
CYG48_RS17135	COG3254	rhamnose metabolic process
CYG48_RS17155	COG1172	Belongs to the binding-protein-dependent transport system permease family
CYG48_RS17160	COG1129	ABC transporter
CYG48_RS17165	COG1609	Transcriptional regulator
CYG48_RS17180	COG1129	ABC transporter
CYG48_RS17190	COG1172	Belongs to the binding-protein-dependent transport system permease family
CYG48_RS17205	COG1175	transmembrane transport
CYG48_RS17210	COG1653	transport
CYG48_RS17240	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CYG48_RS17260	COG0765	amino acid transport
CYG48_RS17270	COG2186	Transcriptional regulator
CYG48_RS17280	COG1522	sequence-specific DNA binding
CYG48_RS17290	COG0840	transmembrane signaling receptor activity
CYG48_RS17300	COG4608	Belongs to the ABC transporter superfamily
CYG48_RS17305	COG0444	Belongs to the ABC transporter superfamily
CYG48_RS17310	COG1028	Short-chain dehydrogenase reductase Sdr
CYG48_RS17315	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CYG48_RS17325	COG0747	negative chemotaxis
CYG48_RS17350	COG2010	Cytochrome c
CYG48_RS17350	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CYG48_RS17355	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CYG48_RS17365	COG1473	amidohydrolase
CYG48_RS17370	COG1126	abc transporter atp-binding protein
CYG48_RS17375	COG0765	amino acid transport
CYG48_RS17395	COG3842	ATPase activity
CYG48_RS17400	COG0395	ABC-type sugar transport system, permease component
CYG48_RS17415	COG0626	cystathionine gamma-synthase activity
CYG48_RS17420	COG2186	Transcriptional regulator
CYG48_RS17430	COG0019	diaminopimelate decarboxylase activity
CYG48_RS17440	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CYG48_RS17450	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CYG48_RS17460	COG0583	DNA-binding transcription factor activity
CYG48_RS17465	COG0438	transferase activity, transferring glycosyl groups
CYG48_RS17475	COG3422	double-strand break repair
CYG48_RS17480	COG5002	protein histidine kinase activity
CYG48_RS17495	COG1396	sequence-specific DNA binding
CYG48_RS17495	COG3800	Transcriptional regulator
CYG48_RS17530	COG3321	synthase
CYG48_RS17530	COG1028	Short-chain dehydrogenase reductase Sdr
CYG48_RS17530	COG0604	alcohol dehydrogenase
CYG48_RS17535	COG0583	DNA-binding transcription factor activity
CYG48_RS17540	COG0596	Alpha beta hydrolase
CYG48_RS17560	COG0431	NADPH-dependent FMN reductase
CYG48_RS17600	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CYG48_RS17625	COG0110	maltose O-acetyltransferase activity
CYG48_RS17630	COG1271	oxidase subunit
CYG48_RS17635	COG1294	oxidase, subunit
CYG48_RS17650	COG0840	transmembrane signaling receptor activity
CYG48_RS17655	COG2358	TRAP transporter, solute receptor (TAXI family
CYG48_RS17690	COG0683	leucine binding
CYG48_RS17715	COG1012	belongs to the aldehyde dehydrogenase family
CYG48_RS17720	COG2268	Band 7 protein
CYG48_RS17730	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CYG48_RS17745	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CYG48_RS17750	COG0601	transmembrane transport
CYG48_RS17755	COG0596	Alpha beta hydrolase
CYG48_RS17785	COG1414	Transcriptional regulator
CYG48_RS17795	COG2197	response regulator
CYG48_RS17840	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CYG48_RS17875	COG1596	polysaccharide export
CYG48_RS17900	COG0444	Belongs to the ABC transporter superfamily
CYG48_RS17915	COG4172	Belongs to the ABC transporter superfamily
CYG48_RS17965	COG0463	Glycosyl transferase, family 2
CYG48_RS17970	COG0438	transferase activity, transferring glycosyl groups
CYG48_RS17985	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CYG48_RS18005	COG2197	response regulator
CYG48_RS18060	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CYG48_RS18065	COG1780	Probably involved in ribonucleotide reductase function
CYG48_RS18125	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CYG48_RS18125	COG2010	Cytochrome c
CYG48_RS18150	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CYG48_RS18165	COG0243	molybdopterin cofactor binding
CYG48_RS18200	COG0028	Belongs to the TPP enzyme family
CYG48_RS18210	COG1028	Short-chain dehydrogenase reductase Sdr
CYG48_RS18225	COG0596	Alpha beta hydrolase
CYG48_RS18235	COG0697	spore germination
CYG48_RS18270	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CYG48_RS18275	COG0028	Belongs to the TPP enzyme family
CYG48_RS18280	COG0251	oxidation-reduction process
CYG48_RS18285	COG3842	ATPase activity
CYG48_RS18290	COG1177	transmembrane transport
CYG48_RS18295	COG1176	ABC-type spermidine putrescine transport system, permease component I
CYG48_RS18330	COG4948	Mandelate Racemase Muconate Lactonizing
CYG48_RS18340	COG1802	Transcriptional regulator
CYG48_RS18350	COG0601	transmembrane transport
CYG48_RS18355	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CYG48_RS18370	COG3920	Histidine kinase
CYG48_RS18375	COG0784	Response regulator, receiver
CYG48_RS18375	COG4191	Histidine kinase
CYG48_RS18385	COG3706	GGDEF domain
CYG48_RS18390	COG4372	Transposase
CYG48_RS18395	COG3436	PFAM IS66 Orf2 family protein
CYG48_RS18400	COG2963	transposase activity
CYG48_RS18435	COG3920	Histidine kinase
CYG48_RS18445	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CYG48_RS18470	COG0840	transmembrane signaling receptor activity
CYG48_RS18480	COG5001	Diguanylate cyclase
CYG48_RS18520	COG1285	pathogenesis
CYG48_RS18535	COG1253	flavin adenine dinucleotide binding
CYG48_RS18570	COG1492	cobalamin metabolic process
CYG48_RS18645	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
CYG48_RS18655	COG1797	cobyrinic acid a,c-diamide synthase activity
CYG48_RS18660	COG3158	transport of potassium into the cell
CYG48_RS18670	COG2814	Major facilitator Superfamily
CYG48_RS18675	COG4774	siderophore transport
CYG48_RS18690	COG3077	Addiction module antitoxin, RelB DinJ family
CYG48_RS18730	COG2860	membrane
CYG48_RS18735	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CYG48_RS18740	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CYG48_RS18780	COG1090	epimerase
CYG48_RS18785	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CYG48_RS18790	COG0747	negative chemotaxis
CYG48_RS18795	COG0444	Belongs to the ABC transporter superfamily
CYG48_RS18800	COG4608	Belongs to the ABC transporter superfamily
CYG48_RS18805	COG0601	transmembrane transport
CYG48_RS18810	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CYG48_RS18815	COG0584	glycerophosphoryl diester phosphodiesterase
CYG48_RS18920	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CYG48_RS18925	COG0601	transmembrane transport
CYG48_RS18930	COG0583	DNA-binding transcription factor activity
CYG48_RS18965	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CYG48_RS18970	COG2309	aminopeptidase activity
CYG48_RS18975	COG2079	MmgE PrpD family protein
CYG48_RS19010	COG4948	Mandelate Racemase Muconate Lactonizing
CYG48_RS19035	COG2086	electron transfer activity
CYG48_RS19040	COG1024	Enoyl-CoA hydratase
CYG48_RS19050	COG1960	acyl-CoA dehydrogenase activity
CYG48_RS19055	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CYG48_RS19065	COG1304	FMN binding
CYG48_RS19070	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CYG48_RS19100	COG2814	Major facilitator Superfamily
CYG48_RS19145	COG0753	catalase activity
CYG48_RS19150	COG0697	spore germination
CYG48_RS19155	COG1028	Short-chain dehydrogenase reductase Sdr
CYG48_RS19160	COG1309	transcriptional regulator
CYG48_RS19165	COG3246	L-lysine catabolic process to acetate
CYG48_RS19200	COG1028	Short-chain dehydrogenase reductase Sdr
CYG48_RS19205	COG3836	Belongs to the HpcH HpaI aldolase family
CYG48_RS19230	COG0277	FAD linked oxidase domain protein
CYG48_RS19235	COG4166	transmembrane transport
CYG48_RS19240	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CYG48_RS19250	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CYG48_RS19255	COG0444	Belongs to the ABC transporter superfamily
CYG48_RS19260	COG4608	Belongs to the ABC transporter superfamily
CYG48_RS19265	COG0436	Aminotransferase
CYG48_RS19285	COG0559	Belongs to the binding-protein-dependent transport system permease family
CYG48_RS19310	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CYG48_RS19335	COG1846	Transcriptional regulator
CYG48_RS19335	COG1940	carbohydrate kinase activity
CYG48_RS19340	COG4213	ABC transporter substrate-binding protein
CYG48_RS19345	COG4214	carbohydrate transport
CYG48_RS19350	COG1129	ABC transporter
CYG48_RS19365	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CYG48_RS19370	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CYG48_RS19380	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CYG48_RS19390	COG3185	4-Hydroxyphenylpyruvate dioxygenase
CYG48_RS19390	COG1082	Xylose isomerase domain protein TIM barrel
CYG48_RS19395	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CYG48_RS19425	COG3485	protocatechuate 3,4-dioxygenase
CYG48_RS19430	COG3485	protocatechuate 3,4-dioxygenase
CYG48_RS19435	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CYG48_RS19440	COG0596	Alpha beta hydrolase
CYG48_RS19445	COG0583	DNA-binding transcription factor activity
CYG48_RS19455	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CYG48_RS19475	COG1192	Involved in chromosome partitioning
CYG48_RS19480	COG1475	DNA binding
CYG48_RS19485	COG1414	Transcriptional regulator
CYG48_RS19505	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
CYG48_RS19515	COG2188	Transcriptional regulator
CYG48_RS19525	COG0601	transmembrane transport
CYG48_RS19530	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CYG48_RS19535	COG0405	Gamma-glutamyltransferase
CYG48_RS19565	COG1840	ABC-type Fe3 transport system, periplasmic component
CYG48_RS19575	COG0395	ABC-type sugar transport system, permease component
CYG48_RS19590	COG2313	pseudouridylate synthase activity
CYG48_RS19595	COG1522	sequence-specific DNA binding
CYG48_RS19595	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CYG48_RS19605	COG1172	Belongs to the binding-protein-dependent transport system permease family
CYG48_RS19610	COG1172	Belongs to the binding-protein-dependent transport system permease family
CYG48_RS19620	COG1879	ABC-type sugar transport system periplasmic component
CYG48_RS19625	COG1349	DNA-binding transcription factor activity
CYG48_RS19630	COG1028	Short-chain dehydrogenase reductase Sdr
CYG48_RS19630	COG3347	Dehydrogenase
CYG48_RS19635	COG4952	isomerase
CYG48_RS19640	COG1640	4-alpha-glucanotransferase
CYG48_RS19650	COG1012	belongs to the aldehyde dehydrogenase family
CYG48_RS19660	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CYG48_RS19665	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
CYG48_RS19670	COG2080	2 iron, 2 sulfur cluster binding
CYG48_RS19675	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CYG48_RS19680	COG0784	Response regulator, receiver
CYG48_RS19680	COG4191	Histidine kinase
CYG48_RS19725	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CYG48_RS19730	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CYG48_RS19735	COG1312	Catalyzes the dehydration of D-mannonate
CYG48_RS19740	COG1063	alcohol dehydrogenase
CYG48_RS19745	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CYG48_RS19755	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CYG48_RS19765	COG1609	Transcriptional regulator
CYG48_RS19770	COG2084	Dehydrogenase
CYG48_RS19775	COG3395	kinase activity
CYG48_RS19780	COG0235	Class ii aldolase
CYG48_RS19785	COG3622	Belongs to the hyi family
CYG48_RS19790	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CYG48_RS19795	COG1028	Short-chain dehydrogenase reductase Sdr
CYG48_RS19800	COG3842	ATPase activity
CYG48_RS19810	COG1175	transmembrane transport
CYG48_RS19815	COG0395	ABC-type sugar transport system, permease component
CYG48_RS19820	COG0625	glutathione transferase activity
CYG48_RS19830	COG4251	negative regulation of phosphorylation
CYG48_RS19835	COG0784	Response regulator, receiver
CYG48_RS19850	COG0850	regulation of cytokinetic process
CYG48_RS19855	COG2894	cell division
CYG48_RS19860	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
CYG48_RS19870	COG3685	Protein conserved in bacteria
CYG48_RS19885	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CYG48_RS19890	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CYG48_RS19900	COG2354	Protein conserved in bacteria
CYG48_RS19915	COG3546	catalase activity
CYG48_RS19920	COG0671	phosphoesterase, PA-phosphatase related
CYG48_RS19935	COG0494	nUDIX hydrolase
CYG48_RS19940	COG0725	ABC transporter, periplasmic molybdate-binding protein
CYG48_RS19945	COG4149	molybdate abc transporter
CYG48_RS19950	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
CYG48_RS19960	COG0765	amino acid transport
CYG48_RS19965	COG0765	amino acid transport
CYG48_RS19970	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CYG48_RS19975	COG1126	abc transporter atp-binding protein
CYG48_RS19980	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CYG48_RS20000	COG0247	lactate metabolic process
CYG48_RS20005	COG0277	FAD linked oxidase domain protein
CYG48_RS20010	COG0277	FAD linked oxidase domain protein
CYG48_RS20025	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
CYG48_RS20035	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CYG48_RS20040	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CYG48_RS20045	COG0477	Major facilitator Superfamily
CYG48_RS20050	COG0006	proline dipeptidase activity
CYG48_RS20070	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CYG48_RS20075	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CYG48_RS20080	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CYG48_RS20125	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CYG48_RS20130	COG1840	ABC-type Fe3 transport system, periplasmic component
CYG48_RS20135	COG4208	sulfate ABC transporter
CYG48_RS20140	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CYG48_RS20145	COG0697	spore germination
CYG48_RS20165	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CYG48_RS20210	COG0028	Belongs to the TPP enzyme family
CYG48_RS20215	COG0784	Response regulator, receiver
CYG48_RS20215	COG4191	Histidine kinase
CYG48_RS20220	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
CYG48_RS20230	COG0318	PFAM AMP-dependent synthetase and ligase
CYG48_RS20235	COG1024	Enoyl-CoA hydratase
CYG48_RS20240	COG1028	Short-chain dehydrogenase reductase Sdr
CYG48_RS20265	COG0784	Response regulator, receiver
CYG48_RS20265	COG4191	Histidine kinase
CYG48_RS20275	COG1840	ABC-type Fe3 transport system, periplasmic component
CYG48_RS20285	COG3842	ATPase activity
CYG48_RS20305	COG1902	pentaerythritol trinitrate reductase activity
CYG48_RS20310	COG0025	NhaP-type Na H and K H
CYG48_RS20355	COG1940	carbohydrate kinase activity
CYG48_RS20360	COG2182	Extracellular solute-binding protein
CYG48_RS20365	COG1175	transmembrane transport
CYG48_RS20370	COG0395	ABC-type sugar transport system, permease component
CYG48_RS20375	COG0165	Argininosuccinate lyase
CYG48_RS20380	COG3842	ATPase activity
CYG48_RS20385	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CYG48_RS20390	COG0366	Alpha amylase catalytic
CYG48_RS20405	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CYG48_RS20420	COG2195	Cleaves the N-terminal amino acid of tripeptides
CYG48_RS20440	COG2137	regulation of response to DNA damage stimulus
CYG48_RS20445	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CYG48_RS20450	COG4149	molybdate abc transporter
CYG48_RS20455	COG1176	ABC-type spermidine putrescine transport system, permease component I
CYG48_RS20460	COG3842	ATPase activity
CYG48_RS20465	COG1653	transport
CYG48_RS20485	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CYG48_RS20505	COG0670	Belongs to the BI1 family
CYG48_RS20515	COG1595	DNA-templated transcription, initiation
CYG48_RS20520	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CYG48_RS20535	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CYG48_RS20550	COG0559	Belongs to the binding-protein-dependent transport system permease family
CYG48_RS20575	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
CYG48_RS20580	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CYG48_RS20610	COG1028	Short-chain dehydrogenase reductase Sdr
CYG48_RS20615	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CYG48_RS20625	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
CYG48_RS20735	COG2076	Multidrug Resistance protein
CYG48_RS20750	COG3698	Phosphodiester glycosidase
CYG48_RS20760	COG1595	DNA-templated transcription, initiation
CYG48_RS20780	COG2113	Glycine betaine
CYG48_RS20785	COG4176	ABC-type proline glycine betaine transport system permease component
CYG48_RS20815	COG1028	Short-chain dehydrogenase reductase Sdr
CYG48_RS20835	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CYG48_RS20840	COG1116	anion transmembrane transporter activity
CYG48_RS20845	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CYG48_RS20850	COG1126	abc transporter atp-binding protein
CYG48_RS20855	COG0765	amino acid transport
CYG48_RS20860	COG0765	amino acid transport
CYG48_RS20865	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CYG48_RS20870	COG3608	succinylglutamate desuccinylase aspartoacylase
CYG48_RS20875	COG0006	proline dipeptidase activity
CYG48_RS20880	COG2423	ornithine cyclodeaminase activity
CYG48_RS20885	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CYG48_RS20890	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CYG48_RS20895	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CYG48_RS20900	COG1012	belongs to the aldehyde dehydrogenase family
CYG48_RS20905	COG1522	sequence-specific DNA binding
CYG48_RS20920	COG0640	Transcriptional regulator
CYG48_RS20930	COG2199	diguanylate cyclase activity
CYG48_RS20945	COG1278	Cold shock
CYG48_RS20960	COG2186	Transcriptional regulator
CYG48_RS20965	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CYG48_RS20985	COG0318	PFAM AMP-dependent synthetase and ligase
CYG48_RS20990	COG4206	TonB-dependent receptor
CYG48_RS20995	COG4558	Periplasmic binding protein
CYG48_RS21000	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CYG48_RS21005	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CYG48_RS21025	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CYG48_RS21030	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
CYG48_RS21060	COG0697	spore germination
CYG48_RS21065	COG0697	spore germination
CYG48_RS21105	COG5001	Diguanylate cyclase
CYG48_RS21115	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CYG48_RS21120	COG0747	negative chemotaxis
CYG48_RS21125	COG0601	transmembrane transport
CYG48_RS21135	COG3964	amidohydrolase
CYG48_RS21150	COG1921	L-seryl-tRNASec selenium transferase activity
CYG48_RS21155	COG4172	Belongs to the ABC transporter superfamily
CYG48_RS21165	COG0747	negative chemotaxis
CYG48_RS21180	COG0601	transmembrane transport
CYG48_RS21185	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CYG48_RS21190	COG4172	Belongs to the ABC transporter superfamily
CYG48_RS21200	COG5001	Diguanylate cyclase
CYG48_RS21215	COG0747	negative chemotaxis
CYG48_RS21225	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CYG48_RS21250	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
CYG48_RS21255	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CYG48_RS21295	COG2822	iron ion transport
CYG48_RS21305	COG2801	Transposase and inactivated derivatives
CYG48_RS21350	COG3842	ATPase activity
CYG48_RS21360	COG0395	ABC-type sugar transport system, permease component
CYG48_RS21375	COG1278	Cold shock
CYG48_RS21380	COG2301	Belongs to the HpcH HpaI aldolase family
CYG48_RS21385	COG2030	dehydratase
CYG48_RS21395	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CYG48_RS21400	COG1960	acyl-CoA dehydrogenase activity
CYG48_RS21410	COG3842	ATPase activity
CYG48_RS21420	COG1175	transmembrane transport
CYG48_RS21425	COG1653	transport
CYG48_RS21445	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
CYG48_RS21450	COG0352	thiamine-phosphate diphosphorylase activity
CYG48_RS21455	COG0351	phosphomethylpyrimidine kinase
CYG48_RS21465	COG0243	molybdopterin cofactor binding
CYG48_RS21505	COG0683	leucine binding
CYG48_RS21520	COG0183	Belongs to the thiolase family
CYG48_RS21525	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CYG48_RS21535	COG1414	Transcriptional regulator
CYG48_RS21540	COG1028	Short-chain dehydrogenase reductase Sdr
CYG48_RS21545	COG0745	RESPONSE REGULATOR receiver
CYG48_RS21550	COG4191	Histidine kinase
CYG48_RS21550	COG0784	Response regulator, receiver
CYG48_RS21560	COG3300	MHYT domain
CYG48_RS21560	COG5001	Diguanylate cyclase
CYG48_RS21580	COG1136	(ABC) transporter
CYG48_RS21585	COG0577	efflux transmembrane transporter activity
CYG48_RS21610	COG3300	MHYT domain
CYG48_RS21610	COG5001	Diguanylate cyclase
CYG48_RS21630	COG1120	ATPase activity
CYG48_RS21635	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CYG48_RS21640	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CYG48_RS21655	COG2207	Transcriptional regulator
CYG48_RS21660	COG0326	Molecular chaperone. Has ATPase activity
CYG48_RS21665	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
CYG48_RS21690	COG1231	oxidoreductase activity
CYG48_RS21715	COG3718	enzyme involved in inositol metabolism
CYG48_RS21725	COG3962	Belongs to the TPP enzyme family
CYG48_RS21735	COG1737	Transcriptional regulator
CYG48_RS21740	COG0673	inositol 2-dehydrogenase activity
CYG48_RS21745	COG1609	Transcriptional regulator
CYG48_RS21750	COG1840	ABC-type Fe3 transport system, periplasmic component
CYG48_RS21760	COG3842	ATPase activity
CYG48_RS21770	COG1653	transport
CYG48_RS21775	COG1175	transmembrane transport
CYG48_RS21780	COG0395	ABC-type sugar transport system, permease component
CYG48_RS21785	COG3842	ATPase activity
CYG48_RS21825	COG0513	Belongs to the DEAD box helicase family
CYG48_RS21830	COG0683	leucine binding
CYG48_RS21840	COG4191	Histidine kinase
CYG48_RS21860	COG0657	acetylesterase activity
CYG48_RS21865	COG0583	DNA-binding transcription factor activity
CYG48_RS21875	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CYG48_RS21875	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CYG48_RS21880	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CYG48_RS21885	COG0028	Belongs to the TPP enzyme family
CYG48_RS21895	COG0411	ABC transporter
CYG48_RS21915	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CYG48_RS21915	COG2205	protein histidine kinase activity
CYG48_RS21920	COG0745	RESPONSE REGULATOR receiver
CYG48_RS21940	COG1764	response to oxidative stress
CYG48_RS21960	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CYG48_RS21970	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CYG48_RS21975	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CYG48_RS21980	COG1121	(ABC) transporter
CYG48_RS22030	COG1131	(ABC) transporter
CYG48_RS22035	COG4251	negative regulation of phosphorylation
CYG48_RS22040	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CYG48_RS22055	COG0444	Belongs to the ABC transporter superfamily
CYG48_RS22090	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CYG48_RS22100	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
CYG48_RS22105	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CYG48_RS22150	COG1250	3-hydroxyacyl-CoA dehydrogenase
CYG48_RS22155	COG2188	Transcriptional regulator
CYG48_RS22200	COG0455	bacterial-type flagellum organization
CYG48_RS22210	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs