locus-tag	class	description
NEJAP_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
NEJAP_RS00010	COG0592	DNA-directed DNA polymerase activity
NEJAP_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
NEJAP_RS00030	COG3813	Protein conserved in bacteria
NEJAP_RS00035	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
NEJAP_RS00045	COG0583	DNA-binding transcription factor activity
NEJAP_RS00050	COG0019	diaminopimelate decarboxylase activity
NEJAP_RS00055	COG1522	sequence-specific DNA binding
NEJAP_RS00070	COG0751	glycine-tRNA ligase activity
NEJAP_RS00075	COG0752	glycyl-tRNA synthetase alpha subunit
NEJAP_RS00080	COG1560	Kdo2-lipid A biosynthetic process
NEJAP_RS00085	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
NEJAP_RS00090	COG0569	domain protein
NEJAP_RS00095	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
NEJAP_RS00105	COG0242	peptide deformylase activity
NEJAP_RS00115	COG0758	DNA mediated transformation
NEJAP_RS00120	COG0009	L-threonylcarbamoyladenylate synthase
NEJAP_RS00125	COG0408	coproporphyrinogen oxidase activity
NEJAP_RS00130	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
NEJAP_RS00135	COG1067	ATP-dependent peptidase activity
NEJAP_RS00155	COG1522	sequence-specific DNA binding
NEJAP_RS00185	COG1858	cytochrome C peroxidase
NEJAP_RS00225	COG0583	DNA-binding transcription factor activity
NEJAP_RS00245	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
NEJAP_RS00250	COG0339	signal peptide processing
NEJAP_RS00260	COG0519	Catalyzes the synthesis of GMP from XMP
NEJAP_RS00265	COG0534	Mate efflux family protein
NEJAP_RS00270	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NEJAP_RS00275	COG1121	(ABC) transporter
NEJAP_RS00280	COG0735	belongs to the Fur family
NEJAP_RS00285	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
NEJAP_RS00315	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
NEJAP_RS00320	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
NEJAP_RS00330	COG0535	radical SAM domain protein
NEJAP_RS00340	COG0739	heme binding
NEJAP_RS00350	COG2354	Protein conserved in bacteria
NEJAP_RS00375	COG2205	protein histidine kinase activity
NEJAP_RS00375	COG2202	Pas domain
NEJAP_RS00390	COG1280	lysine exporter protein (LysE YggA)
NEJAP_RS00420	COG1131	(ABC) transporter
NEJAP_RS00465	COG0583	DNA-binding transcription factor activity
NEJAP_RS00475	COG2203	Gaf domain
NEJAP_RS00475	COG2199	diguanylate cyclase activity
NEJAP_RS00485	COG3768	UPF0283 membrane protein
NEJAP_RS00490	COG3106	COG3106 Predicted ATPase
NEJAP_RS00515	COG2197	response regulator
NEJAP_RS00520	COG0840	transmembrane signaling receptor activity
NEJAP_RS00530	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
NEJAP_RS00535	COG4988	ABC transporter
NEJAP_RS00545	COG4890	Cyd operon protein YbgT
NEJAP_RS00550	COG1294	oxidase, subunit
NEJAP_RS00560	COG0446	pyridine nucleotide-disulphide oxidoreductase
NEJAP_RS00585	COG0154	amidase activity
NEJAP_RS00595	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
NEJAP_RS00635	COG2759	Belongs to the formate--tetrahydrofolate ligase family
NEJAP_RS00640	COG0840	transmembrane signaling receptor activity
NEJAP_RS00650	COG0788	formyltetrahydrofolate deformylase activity
NEJAP_RS00660	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
NEJAP_RS00670	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NEJAP_RS00680	COG2267	carboxylic ester hydrolase activity
NEJAP_RS00705	COG0583	DNA-binding transcription factor activity
NEJAP_RS00710	COG2515	1-aminocyclopropane-1-carboxylate deaminase
NEJAP_RS00715	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
NEJAP_RS00720	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
NEJAP_RS00725	COG0386	Belongs to the glutathione peroxidase family
NEJAP_RS00735	COG2423	ornithine cyclodeaminase activity
NEJAP_RS00740	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NEJAP_RS00750	COG1304	FMN binding
NEJAP_RS00765	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
NEJAP_RS00770	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
NEJAP_RS00770	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
NEJAP_RS00775	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
NEJAP_RS00780	COG1028	Short-chain dehydrogenase reductase Sdr
NEJAP_RS00805	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
NEJAP_RS00820	COG0131	Imidazoleglycerol-phosphate dehydratase
NEJAP_RS00825	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
NEJAP_RS00830	COG0107	imidazoleglycerol-phosphate synthase activity
NEJAP_RS00845	COG2200	EAL domain
NEJAP_RS00875	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
NEJAP_RS00880	COG1122	ATPase activity
NEJAP_RS00885	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
NEJAP_RS00890	COG1268	BioY protein
NEJAP_RS00925	COG4221	oxidoreductase activity
NEJAP_RS00945	COG0222	ribosome binding
NEJAP_RS00975	COG0583	DNA-binding transcription factor activity
NEJAP_RS00995	COG0583	DNA-binding transcription factor activity
NEJAP_RS01000	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
NEJAP_RS01015	COG1187	pseudouridine synthase activity
NEJAP_RS01020	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
NEJAP_RS01025	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
NEJAP_RS01030	COG0501	Belongs to the peptidase M48B family
NEJAP_RS01035	COG1309	transcriptional regulator
NEJAP_RS01040	COG0742	ribosomal rna small subunit methyltransferase
NEJAP_RS01050	COG2884	Cell division ATP-binding protein ftsE
NEJAP_RS01055	COG2177	Part of the ABC transporter FtsEX involved in
NEJAP_RS01065	COG2363	Small membrane protein
NEJAP_RS01075	COG2022	thiamine diphosphate biosynthetic process
NEJAP_RS01080	COG0220	tRNA (guanine-N7-)-methyltransferase activity
NEJAP_RS01090	COG0659	secondary active sulfate transmembrane transporter activity
NEJAP_RS01100	COG0745	RESPONSE REGULATOR receiver
NEJAP_RS01105	COG2205	protein histidine kinase activity
NEJAP_RS01120	COG0004	ammonium transporteR
NEJAP_RS01150	COG0210	DNA helicase
NEJAP_RS01170	COG0427	acetyl-CoA hydrolase
NEJAP_RS01175	COG0427	acetyl-CoA hydrolase
NEJAP_RS01180	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NEJAP_RS01195	COG0348	domain, Protein
NEJAP_RS01195	COG3901	Regulator of nitric oxide reductase transcription
NEJAP_RS01215	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
NEJAP_RS01235	COG3706	GGDEF domain
NEJAP_RS01235	COG4251	negative regulation of phosphorylation
NEJAP_RS01235	COG2203	Gaf domain
NEJAP_RS01235	COG5001	Diguanylate cyclase
NEJAP_RS01240	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
NEJAP_RS01245	COG5001	Diguanylate cyclase
NEJAP_RS01245	COG3300	MHYT domain
NEJAP_RS01255	COG0129	dihydroxy-acid dehydratase activity
NEJAP_RS01265	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NEJAP_RS01290	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
NEJAP_RS01290	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
NEJAP_RS01300	COG0306	phosphate transporter
NEJAP_RS01305	COG1392	Phosphate transport regulator
NEJAP_RS01345	COG1560	Kdo2-lipid A biosynthetic process
NEJAP_RS01350	COG1132	(ABC) transporter
NEJAP_RS01355	COG1519	Transferase
NEJAP_RS01375	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
NEJAP_RS01395	COG0635	Involved in the biosynthesis of porphyrin-containing compound
NEJAP_RS01400	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
NEJAP_RS01410	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
NEJAP_RS01410	COG2813	Specifically methylates the guanine in position
NEJAP_RS01415	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
NEJAP_RS01420	COG1872	DUF167
NEJAP_RS01455	COG0540	Belongs to the ATCase OTCase family
NEJAP_RS01465	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
NEJAP_RS01470	COG1678	Uncharacterized ACR, COG1678
NEJAP_RS01480	COG0189	ligase activity
NEJAP_RS01485	COG1385	rRNA (uridine-N3-)-methyltransferase activity
NEJAP_RS01495	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
NEJAP_RS01500	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
NEJAP_RS01505	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
NEJAP_RS01510	COG0126	phosphoglycerate kinase activity
NEJAP_RS01520	COG2095	MarC family integral membrane protein
NEJAP_RS01530	COG0251	oxidation-reduction process
NEJAP_RS01535	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
NEJAP_RS01560	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NEJAP_RS01565	COG1012	belongs to the aldehyde dehydrogenase family
NEJAP_RS01570	COG4336	lyase activity
NEJAP_RS01580	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
NEJAP_RS01585	COG1984	allophanate hydrolase subunit 2
NEJAP_RS01610	COG0109	protoheme IX farnesyltransferase activity
NEJAP_RS01615	COG1612	heme a metabolic process
NEJAP_RS01640	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
NEJAP_RS01645	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NEJAP_RS01650	COG1565	acr, cog1565
NEJAP_RS01650	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
NEJAP_RS01670	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
NEJAP_RS01680	COG1511	domain protein
NEJAP_RS01680	COG3264	Mechanosensitive ion channel
NEJAP_RS01690	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NEJAP_RS01695	COG3123	guanosine phosphorylase activity
NEJAP_RS01700	COG0583	DNA-binding transcription factor activity
NEJAP_RS01705	COG2814	Major facilitator Superfamily
NEJAP_RS01715	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
NEJAP_RS01725	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NEJAP_RS01730	COG0179	Fumarylacetoacetate (FAA) hydrolase
NEJAP_RS01740	COG1981	membrane
NEJAP_RS01750	COG2226	methyltransferase
NEJAP_RS01760	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
NEJAP_RS01765	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
NEJAP_RS01775	COG0018	arginyl-trna synthetase
NEJAP_RS01780	COG0840	transmembrane signaling receptor activity
NEJAP_RS01785	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
NEJAP_RS01790	COG0254	rRNA binding
NEJAP_RS01800	COG0281	malic enzyme
NEJAP_RS01835	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
NEJAP_RS01840	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
NEJAP_RS01850	COG0070	glutamate synthase
NEJAP_RS01850	COG0069	glutamate synthase activity
NEJAP_RS01850	COG0067	glutamate synthase
NEJAP_RS01855	COG0493	'glutamate synthase
NEJAP_RS01875	COG0251	oxidation-reduction process
NEJAP_RS01900	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NEJAP_RS01905	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
NEJAP_RS01905	COG0506	proline dehydrogenase activity
NEJAP_RS01905	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
NEJAP_RS01915	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
NEJAP_RS01920	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
NEJAP_RS01930	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
NEJAP_RS01935	COG0288	reversible hydration of carbon dioxide
NEJAP_RS01945	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
NEJAP_RS01960	COG0488	(ABC) transporter
NEJAP_RS01970	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
NEJAP_RS01980	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NEJAP_RS01980	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NEJAP_RS01995	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
NEJAP_RS02000	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NEJAP_RS02010	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
NEJAP_RS02035	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NEJAP_RS02065	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
NEJAP_RS02070	COG0142	geranyltranstransferase activity
NEJAP_RS02075	COG1722	exodeoxyribonuclease VII activity
NEJAP_RS02080	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
NEJAP_RS02085	COG1360	Flagellar Motor Protein
NEJAP_RS02125	COG0829	nickel cation binding
NEJAP_RS02130	COG0831	urea catabolic process
NEJAP_RS02135	COG0832	Belongs to the urease beta subunit family
NEJAP_RS02140	COG0804	urea catabolic process
NEJAP_RS02145	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
NEJAP_RS02155	COG0830	nickel cation binding
NEJAP_RS02165	COG0433	COG0433 Predicted ATPase
NEJAP_RS02170	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NEJAP_RS02175	COG0438	transferase activity, transferring glycosyl groups
NEJAP_RS02180	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
NEJAP_RS02205	COG0625	glutathione transferase activity
NEJAP_RS02230	COG1177	transmembrane transport
NEJAP_RS02235	COG1176	ABC-type spermidine putrescine transport system, permease component I
NEJAP_RS02245	COG3842	ATPase activity
NEJAP_RS02250	COG4115	mRNA cleavage
NEJAP_RS02255	COG2161	toxin-antitoxin pair type II binding
NEJAP_RS02290	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
NEJAP_RS02295	COG0733	neurotransmitter:sodium symporter activity
NEJAP_RS02305	COG2914	Belongs to the UPF0125 (RnfH) family
NEJAP_RS02315	COG0735	belongs to the Fur family
NEJAP_RS02320	COG0497	DNA recombination
NEJAP_RS02325	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
NEJAP_RS02330	COG0443	Heat shock 70 kDa protein
NEJAP_RS02340	COG1045	serine acetyltransferase
NEJAP_RS02345	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
NEJAP_RS02360	COG3323	Protein of unknown function (DUF1653)
NEJAP_RS02360	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
NEJAP_RS02370	COG1394	ATPase activity, coupled to movement of substances
NEJAP_RS02375	COG1269	ATP hydrolysis coupled proton transport
NEJAP_RS02395	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
NEJAP_RS02410	COG1051	belongs to the nudix hydrolase family
NEJAP_RS02425	COG4536	flavin adenine dinucleotide binding
NEJAP_RS02430	COG4137	Cytochrome C assembly protein
NEJAP_RS02435	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
NEJAP_RS02440	COG0228	four-way junction DNA binding
NEJAP_RS02445	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
NEJAP_RS02450	COG0336	Belongs to the RNA methyltransferase TrmD family
NEJAP_RS02455	COG0335	large ribosomal subunit rRNA binding
NEJAP_RS02465	COG4974	Belongs to the 'phage' integrase family
NEJAP_RS02470	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NEJAP_RS02485	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
NEJAP_RS02510	COG2771	luxR family
NEJAP_RS02510	COG2200	EAL domain
NEJAP_RS02515	COG0494	nUDIX hydrolase
NEJAP_RS02520	COG3151	Protein conserved in bacteria
NEJAP_RS02530	COG3150	esterase
NEJAP_RS02550	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
NEJAP_RS02555	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
NEJAP_RS02565	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
NEJAP_RS02570	COG0768	penicillin binding
NEJAP_RS02575	COG0772	Belongs to the SEDS family
NEJAP_RS02580	COG2951	lytic endotransglycosylase activity
NEJAP_RS02585	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
NEJAP_RS02590	COG1686	Belongs to the peptidase S11 family
NEJAP_RS02605	COG0321	lipoyl(octanoyl) transferase activity
NEJAP_RS02610	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
NEJAP_RS02635	COG0495	leucyl-tRNA aminoacylation
NEJAP_RS02650	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
NEJAP_RS02660	COG0513	Belongs to the DEAD box helicase family
NEJAP_RS02665	COG2258	MOSC domain
NEJAP_RS02700	COG4535	Mg2 and Co2 transporter CorC
NEJAP_RS02705	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
NEJAP_RS02710	COG1702	phosphate starvation-inducible protein PhoH
NEJAP_RS02715	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NEJAP_RS02725	COG1509	lysine 2,3-aminomutase activity
NEJAP_RS02730	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
NEJAP_RS02745	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
NEJAP_RS02755	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NEJAP_RS02765	COG0456	acetyltransferase
NEJAP_RS02770	COG3706	GGDEF domain
NEJAP_RS02770	COG2203	Gaf domain
NEJAP_RS02770	COG5001	Diguanylate cyclase
NEJAP_RS02770	COG4251	negative regulation of phosphorylation
NEJAP_RS02775	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NEJAP_RS02780	COG1522	sequence-specific DNA binding
NEJAP_RS02790	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
NEJAP_RS02805	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
NEJAP_RS02815	COG1012	belongs to the aldehyde dehydrogenase family
NEJAP_RS02820	COG0583	DNA-binding transcription factor activity
NEJAP_RS02855	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
NEJAP_RS02860	COG0084	hydrolase, TatD family'
NEJAP_RS02875	COG2885	chlorophyll binding
NEJAP_RS02880	COG3074	FtsZ-dependent cytokinesis
NEJAP_RS02905	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
NEJAP_RS02915	COG0052	Belongs to the universal ribosomal protein uS2 family
NEJAP_RS02920	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
NEJAP_RS02925	COG0528	UMP kinase activity
NEJAP_RS02930	COG0233	cytoplasmic translational termination
NEJAP_RS02940	COG0575	Belongs to the CDS family
NEJAP_RS02960	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NEJAP_RS02965	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
NEJAP_RS02970	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NEJAP_RS02980	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
NEJAP_RS02985	COG0587	DNA-directed DNA polymerase activity
NEJAP_RS02990	COG0825	malonyl-CoA metabolic process
NEJAP_RS02995	COG0037	tRNA processing
NEJAP_RS03000	COG0504	CTP synthase activity
NEJAP_RS03005	COG0148	phosphopyruvate hydratase activity
NEJAP_RS03015	COG0585	pseudouridine synthase activity
NEJAP_RS03020	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
NEJAP_RS03025	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
NEJAP_RS03045	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
NEJAP_RS03050	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
NEJAP_RS03055	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
NEJAP_RS03090	COG1757	Na H antiporter
NEJAP_RS03115	COG1760	l-serine dehydratase
NEJAP_RS03125	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
NEJAP_RS03130	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NEJAP_RS03140	COG0010	Belongs to the arginase family
NEJAP_RS03145	COG1012	belongs to the aldehyde dehydrogenase family
NEJAP_RS03150	COG2197	response regulator
NEJAP_RS03165	COG0174	glutamine synthetase
NEJAP_RS03170	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
NEJAP_RS03175	COG3842	ATPase activity
NEJAP_RS03180	COG1176	ABC-type spermidine putrescine transport system, permease component I
NEJAP_RS03185	COG1177	transmembrane transport
NEJAP_RS03190	COG0519	Catalyzes the synthesis of GMP from XMP
NEJAP_RS03200	COG2808	Putative FMN-binding domain
NEJAP_RS03205	COG1280	lysine exporter protein (LysE YggA)
NEJAP_RS03215	COG0174	glutamine synthetase
NEJAP_RS03220	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NEJAP_RS03240	COG1696	Membrane protein involved in D-alanine export
NEJAP_RS03245	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
NEJAP_RS03245	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
NEJAP_RS03255	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
NEJAP_RS03275	COG1757	Na H antiporter
NEJAP_RS03280	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NEJAP_RS03295	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
NEJAP_RS03300	COG1546	Belongs to the CinA family
NEJAP_RS03305	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
NEJAP_RS03310	COG2137	regulation of response to DNA damage stimulus
NEJAP_RS03315	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
NEJAP_RS03320	COG0527	aspartate kinase activity
NEJAP_RS03325	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
NEJAP_RS03350	COG0301	tRNA thio-modification
NEJAP_RS03350	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NEJAP_RS03355	COG3630	sodium ion export across plasma membrane
NEJAP_RS03360	COG0511	ligase activity, forming carbon-carbon bonds
NEJAP_RS03360	COG5016	pyruvate
NEJAP_RS03365	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
NEJAP_RS03370	COG0123	including yeast histone deacetylase and acetoin utilization protein
NEJAP_RS03410	COG2871	sodium ion transport
NEJAP_RS03485	COG2747	anti-sigma28 factor FlgM
NEJAP_RS03495	COG0835	chemotaxis
NEJAP_RS03495	COG0784	Response regulator, receiver
NEJAP_RS03500	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
NEJAP_RS03505	COG1815	bacterial-type flagellum-dependent cell motility
NEJAP_RS03510	COG1558	bacterial-type flagellum-dependent cell motility
NEJAP_RS03525	COG4787	bacterial-type flagellum-dependent cell motility
NEJAP_RS03535	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
NEJAP_RS03540	COG1706	bacterial-type flagellum-dependent cell motility
NEJAP_RS03545	COG1705	Flagellar rod assembly protein muramidase FlgJ
NEJAP_RS03545	COG3951	Flagellar rod assembly protein muramidase FlgJ
NEJAP_RS03555	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
NEJAP_RS03600	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NEJAP_RS03610	COG2205	protein histidine kinase activity
NEJAP_RS03610	COG0784	Response regulator, receiver
NEJAP_RS03620	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NEJAP_RS03635	COG1677	Flagellar hook-basal body complex protein FliE
NEJAP_RS03695	COG1987	bacterial-type flagellum assembly
NEJAP_RS03700	COG1684	flagellar biosynthetic protein fliR
NEJAP_RS03740	COG0784	Response regulator, receiver
NEJAP_RS03740	COG2198	Histidine kinase
NEJAP_RS03740	COG0643	Histidine kinase
NEJAP_RS03745	COG2201	protein-glutamate methylesterase activity
NEJAP_RS03750	COG1192	Involved in chromosome partitioning
NEJAP_RS03765	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
NEJAP_RS03775	COG4133	protoheme IX ABC transporter activity
NEJAP_RS03795	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
NEJAP_RS03800	COG1138	Cytochrome C-type biogenesis protein
NEJAP_RS03820	COG3115	cell septum assembly
NEJAP_RS03820	COG3115	cell septum assembly
NEJAP_RS03825	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
NEJAP_RS03830	COG3089	Belongs to the UPF0270 family
NEJAP_RS03840	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NEJAP_RS03840	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
NEJAP_RS03845	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
NEJAP_RS03865	COG1063	alcohol dehydrogenase
NEJAP_RS03880	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
NEJAP_RS03890	COG2030	dehydratase
NEJAP_RS03895	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
NEJAP_RS03905	COG0583	DNA-binding transcription factor activity
NEJAP_RS03925	COG0358	DNA primase activity
NEJAP_RS03935	COG0828	Belongs to the bacterial ribosomal protein bS21 family
NEJAP_RS03940	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
NEJAP_RS03945	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
NEJAP_RS03950	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
NEJAP_RS03955	COG0617	tRNA 3'-terminal CCA addition
NEJAP_RS03960	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NEJAP_RS03965	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
NEJAP_RS03975	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
NEJAP_RS03990	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
NEJAP_RS04000	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
NEJAP_RS04005	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
NEJAP_RS04015	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
NEJAP_RS04020	COG0546	phosphoglycolate phosphatase activity
NEJAP_RS04035	COG0489	protein tyrosine kinase activity
NEJAP_RS04070	COG0367	asparagine synthase
NEJAP_RS04075	COG0438	transferase activity, transferring glycosyl groups
NEJAP_RS04080	COG0438	transferase activity, transferring glycosyl groups
NEJAP_RS04150	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
NEJAP_RS04225	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
NEJAP_RS04235	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
NEJAP_RS04240	COG2204	response regulator
NEJAP_RS04245	COG2198	Histidine kinase
NEJAP_RS04245	COG0643	Histidine kinase
NEJAP_RS04275	COG3267	Type II secretory pathway component ExeA
NEJAP_RS04275	COG3409	Peptidoglycan-binding domain 1 protein
NEJAP_RS04280	COG3409	Peptidoglycan-binding domain 1 protein
NEJAP_RS04280	COG3267	Type II secretory pathway component ExeA
NEJAP_RS04285	COG1686	Belongs to the peptidase S11 family
NEJAP_RS04295	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
NEJAP_RS04300	COG0134	indole-3-glycerol-phosphate synthase activity
NEJAP_RS04305	COG1765	OsmC-like protein
NEJAP_RS04320	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
NEJAP_RS04325	COG0359	binds to the 23S rRNA
NEJAP_RS04330	COG0305	Participates in initiation and elongation during chromosome replication
NEJAP_RS04340	COG2226	methyltransferase
NEJAP_RS04345	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
NEJAP_RS04355	COG1720	tRNA m6t6A37 methyltransferase activity
NEJAP_RS04365	COG1283	sodium-dependent phosphate transmembrane transporter activity
NEJAP_RS04370	COG1040	competence protein
NEJAP_RS04375	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
NEJAP_RS04380	COG0156	8-amino-7-oxononanoate synthase activity
NEJAP_RS04390	COG2226	methyltransferase
NEJAP_RS04390	COG1073	alpha beta
NEJAP_RS04395	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
NEJAP_RS04410	COG0596	Alpha beta hydrolase
NEJAP_RS04415	COG0545	Peptidyl-prolyl cis-trans isomerase
NEJAP_RS04425	COG1570	exodeoxyribonuclease VII activity
NEJAP_RS04435	COG0519	Catalyzes the synthesis of GMP from XMP
NEJAP_RS04435	COG0518	GMP synthase (glutamine-hydrolyzing) activity
NEJAP_RS04440	COG0590	tRNA wobble adenosine to inosine editing
NEJAP_RS04445	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
NEJAP_RS04470	COG2350	Protein conserved in bacteria
NEJAP_RS04475	COG2917	probably involved in intracellular septation
NEJAP_RS04480	COG0613	PHP domain protein
NEJAP_RS04485	COG0009	L-threonylcarbamoyladenylate synthase
NEJAP_RS04500	COG1028	Short-chain dehydrogenase reductase Sdr
NEJAP_RS04510	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NEJAP_RS04520	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
NEJAP_RS04530	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
NEJAP_RS04535	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
NEJAP_RS04545	COG0776	regulation of translation
NEJAP_RS04555	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
NEJAP_RS04560	COG0284	orotidine-5'-phosphate decarboxylase activity
NEJAP_RS04565	COG1940	carbohydrate kinase activity
NEJAP_RS04580	COG0277	FAD linked oxidase domain protein
NEJAP_RS04590	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
NEJAP_RS04600	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
NEJAP_RS04605	COG2186	Transcriptional regulator
NEJAP_RS04615	COG0508	dehydrogenase complex catalyzes the overall conversion of
NEJAP_RS04620	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
NEJAP_RS04625	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
NEJAP_RS04680	COG0438	transferase activity, transferring glycosyl groups
NEJAP_RS04690	COG0673	inositol 2-dehydrogenase activity
NEJAP_RS04700	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
NEJAP_RS04710	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
NEJAP_RS04715	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
NEJAP_RS04730	COG0166	Belongs to the GPI family
NEJAP_RS04735	COG1210	Utp--glucose-1-phosphate uridylyltransferase
NEJAP_RS04750	COG0489	protein tyrosine kinase activity
NEJAP_RS04750	COG3206	protein involved in exopolysaccharide biosynthesis
NEJAP_RS04755	COG4464	protein tyrosine phosphatase activity
NEJAP_RS04765	COG0521	Mo-molybdopterin cofactor biosynthetic process
NEJAP_RS04770	COG2119	membrane
NEJAP_RS04780	COG1346	cytolysis
NEJAP_RS04785	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
NEJAP_RS04790	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
NEJAP_RS04795	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
NEJAP_RS04800	COG0723	plastoquinol--plastocyanin reductase activity
NEJAP_RS04805	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
NEJAP_RS04810	COG2857	Cytochrome c1
NEJAP_RS04815	COG0625	glutathione transferase activity
NEJAP_RS04820	COG2969	positive regulation of protein catabolic process
NEJAP_RS04825	COG2823	Periplasmic or secreted lipoprotein
NEJAP_RS04830	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
NEJAP_RS04835	COG0792	nuclease activity
NEJAP_RS04845	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
NEJAP_RS04865	COG2001	Belongs to the MraZ family
NEJAP_RS04870	COG0275	rRNA processing
NEJAP_RS04890	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
NEJAP_RS04895	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NEJAP_RS04905	COG0772	Belongs to the SEDS family
NEJAP_RS04910	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
NEJAP_RS04920	COG1181	Belongs to the D-alanine--D-alanine ligase family
NEJAP_RS04925	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
NEJAP_RS04940	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
NEJAP_RS04950	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
NEJAP_RS04955	COG0494	nUDIX hydrolase
NEJAP_RS04960	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
NEJAP_RS04965	COG0237	dephospho-CoA kinase activity
NEJAP_RS05005	COG3023	N-Acetylmuramoyl-L-alanine amidase
NEJAP_RS05010	COG3842	ATPase activity
NEJAP_RS05025	COG1840	ABC-type Fe3 transport system, periplasmic component
NEJAP_RS05035	COG0534	Mate efflux family protein
NEJAP_RS05040	COG1028	Short-chain dehydrogenase reductase Sdr
NEJAP_RS05050	COG3012	SEC-C Motif Domain Protein
NEJAP_RS05055	COG2925	Exonuclease
NEJAP_RS05065	COG1025	Belongs to the peptidase M16 family
NEJAP_RS05090	COG3022	response to hydroperoxide
NEJAP_RS05105	COG2837	iron assimilation
NEJAP_RS05110	COG4771	TonB-dependent receptor
NEJAP_RS05120	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NEJAP_RS05125	COG5002	protein histidine kinase activity
NEJAP_RS05125	COG0784	Response regulator, receiver
NEJAP_RS05125	COG2205	protein histidine kinase activity
NEJAP_RS05130	COG0784	Response regulator, receiver
NEJAP_RS05130	COG2205	protein histidine kinase activity
NEJAP_RS05130	COG5002	protein histidine kinase activity
NEJAP_RS05165	COG1262	PFAM Formylglycine-generating sulfatase enzyme
NEJAP_RS05170	COG2877	3-deoxy-8-phosphooctulonate synthase activity
NEJAP_RS05175	COG0748	coenzyme F420 binding
NEJAP_RS05185	COG1704	LemA family
NEJAP_RS05200	COG5001	Diguanylate cyclase
NEJAP_RS05200	COG4251	negative regulation of phosphorylation
NEJAP_RS05200	COG3706	GGDEF domain
NEJAP_RS05200	COG2203	Gaf domain
NEJAP_RS05210	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NEJAP_RS05215	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NEJAP_RS05220	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NEJAP_RS05225	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
NEJAP_RS05230	COG4660	Part of a membrane complex involved in electron transport
NEJAP_RS05235	COG4659	FMN binding
NEJAP_RS05240	COG4658	electron transport chain
NEJAP_RS05250	COG2878	Part of a membrane complex involved in electron transport
NEJAP_RS05255	COG4657	Part of a membrane complex involved in electron transport
NEJAP_RS05265	COG0175	sulfate reduction
NEJAP_RS05270	COG0730	response to heat
NEJAP_RS05275	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NEJAP_RS05285	COG0175	sulfate reduction
NEJAP_RS05290	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
NEJAP_RS05290	COG1648	precorrin-2 dehydrogenase activity
NEJAP_RS05340	COG2827	Endonuclease containing a URI domain
NEJAP_RS05350	COG0577	efflux transmembrane transporter activity
NEJAP_RS05350	COG1136	(ABC) transporter
NEJAP_RS05355	COG1136	(ABC) transporter
NEJAP_RS05355	COG0577	efflux transmembrane transporter activity
NEJAP_RS05365	COG0436	Aminotransferase
NEJAP_RS05370	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NEJAP_RS05400	COG1793	dna ligase
NEJAP_RS05410	COG3706	GGDEF domain
NEJAP_RS05425	COG2010	Cytochrome c
NEJAP_RS05440	COG0678	peroxiredoxin activity
NEJAP_RS05450	COG3038	cytochrome b561
NEJAP_RS05465	COG0189	ligase activity
NEJAP_RS05475	COG0189	ligase activity
NEJAP_RS05475	COG4067	protein conserved in archaea
NEJAP_RS05520	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NEJAP_RS05560	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
NEJAP_RS05565	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
NEJAP_RS05570	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
NEJAP_RS05580	COG3100	YcgL domain-containing protein
NEJAP_RS05585	COG2983	Belongs to the UPF0260 family
NEJAP_RS05605	COG0545	Peptidyl-prolyl cis-trans isomerase
NEJAP_RS05610	COG1362	aminopeptidase activity
NEJAP_RS05625	COG0714	Associated with various cellular activities
NEJAP_RS05650	COG0745	RESPONSE REGULATOR receiver
NEJAP_RS05660	COG2814	Major facilitator Superfamily
NEJAP_RS05680	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
NEJAP_RS05685	COG1074	ATP-dependent DNA helicase activity
NEJAP_RS05690	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
NEJAP_RS05700	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
NEJAP_RS05705	COG0579	oxidoreductase
NEJAP_RS05715	COG0668	transmembrane transport
NEJAP_RS05725	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
NEJAP_RS05730	COG2199	diguanylate cyclase activity
NEJAP_RS05735	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
NEJAP_RS05740	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
NEJAP_RS05745	COG1611	Belongs to the LOG family
NEJAP_RS05750	COG0183	Belongs to the thiolase family
NEJAP_RS05755	COG0739	heme binding
NEJAP_RS05765	COG0121	glutamine amidotransferase
NEJAP_RS05770	COG0318	PFAM AMP-dependent synthetase and ligase
NEJAP_RS05775	COG1643	Atp-dependent helicase
NEJAP_RS05800	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
NEJAP_RS05805	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NEJAP_RS05815	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NEJAP_RS05820	COG2151	metal-sulfur cluster biosynthetic enzyme
NEJAP_RS05825	COG3396	Phenylacetate-CoA oxygenase
NEJAP_RS05830	COG3460	Phenylacetate-CoA oxygenase
NEJAP_RS05835	COG3396	Phenylacetate-CoA oxygenase
NEJAP_RS05845	COG1704	LemA family
NEJAP_RS05865	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
NEJAP_RS05905	COG1322	Protein conserved in bacteria
NEJAP_RS05925	COG1842	Phage shock protein A
NEJAP_RS05930	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
NEJAP_RS05945	COG1331	Highly conserved protein containing a thioredoxin domain
NEJAP_RS05985	COG0745	RESPONSE REGULATOR receiver
NEJAP_RS06010	COG0348	domain, Protein
NEJAP_RS06015	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NEJAP_RS06045	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
NEJAP_RS06050	COG0626	cystathionine gamma-synthase activity
NEJAP_RS06085	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
NEJAP_RS06090	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NEJAP_RS06095	COG0583	DNA-binding transcription factor activity
NEJAP_RS06105	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NEJAP_RS06110	COG0583	DNA-binding transcription factor activity
NEJAP_RS06115	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NEJAP_RS06120	COG0243	molybdopterin cofactor binding
NEJAP_RS06145	COG1522	sequence-specific DNA binding
NEJAP_RS06155	COG1473	amidohydrolase
NEJAP_RS06160	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
NEJAP_RS06165	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
NEJAP_RS06170	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
NEJAP_RS06175	COG0006	proline dipeptidase activity
NEJAP_RS06190	COG2146	nitrite reductase [NAD(P)H] activity
NEJAP_RS06195	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NEJAP_RS06200	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NEJAP_RS06210	COG2223	nitrite transmembrane transporter activity
NEJAP_RS06220	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NEJAP_RS06220	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
NEJAP_RS06245	COG2040	homocysteine
NEJAP_RS06250	COG0840	transmembrane signaling receptor activity
NEJAP_RS06295	COG1448	Aminotransferase
NEJAP_RS06310	COG0741	lytic transglycosylase activity
NEJAP_RS06335	COG2271	Major facilitator Superfamily
NEJAP_RS06340	COG0133	tryptophan synthase activity
NEJAP_RS06365	COG3706	GGDEF domain
NEJAP_RS06370	COG0659	secondary active sulfate transmembrane transporter activity
NEJAP_RS06375	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
NEJAP_RS06380	COG0385	Bile acid
NEJAP_RS06385	COG0602	queuosine metabolic process
NEJAP_RS06395	COG2974	May be involved in recombination
NEJAP_RS06400	COG1643	Atp-dependent helicase
NEJAP_RS06420	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
NEJAP_RS06445	COG2217	Heavy metal translocating P-type atpase
NEJAP_RS06460	COG2010	Cytochrome c
NEJAP_RS06475	COG3278	Belongs to the heme-copper respiratory oxidase family
NEJAP_RS06505	COG3287	FIST C domain
NEJAP_RS06505	COG2200	EAL domain
NEJAP_RS06505	COG2199	diguanylate cyclase activity
NEJAP_RS06520	COG0534	Mate efflux family protein
NEJAP_RS06525	COG3243	poly(R)-hydroxyalkanoic acid synthase
NEJAP_RS06530	COG0840	transmembrane signaling receptor activity
NEJAP_RS06560	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
NEJAP_RS06565	COG0488	(ABC) transporter
NEJAP_RS06570	COG0589	response to stress
NEJAP_RS06585	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
NEJAP_RS06590	COG0514	ATP-dependent DNA helicase (RecQ)
NEJAP_RS06605	COG1309	transcriptional regulator
NEJAP_RS06610	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
NEJAP_RS06615	COG4266	Belongs to the allantoicase family
NEJAP_RS06645	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NEJAP_RS06675	COG3474	cytochrome
NEJAP_RS06710	COG0402	S-adenosylhomocysteine deaminase activity
NEJAP_RS06720	COG1529	Aldehyde oxidase and xanthine dehydrogenase
NEJAP_RS06730	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NEJAP_RS06740	COG0384	phenazine biosynthesis protein PhzF
NEJAP_RS06750	COG0019	diaminopimelate decarboxylase activity
NEJAP_RS06775	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
NEJAP_RS06780	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
NEJAP_RS06785	COG3454	Phosphonate metabolism
NEJAP_RS06790	COG4778	phosphonate C-P lyase system protein PhnL
NEJAP_RS06795	COG4107	phosphonate C-P lyase system protein PhnK
NEJAP_RS06800	COG3627	carbon phosphorus lyase activity
NEJAP_RS06805	COG3626	phosphonate metabolism
NEJAP_RS06810	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
NEJAP_RS06815	COG3624	Phosphonate C-P lyase system protein PhnG
NEJAP_RS06820	COG2188	Transcriptional regulator
NEJAP_RS06825	COG3639	organic phosphonate transmembrane transporter activity
NEJAP_RS06830	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
NEJAP_RS06835	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
NEJAP_RS06840	COG1115	amino acid carrier protein
NEJAP_RS06850	COG2814	Major facilitator Superfamily
NEJAP_RS06860	COG1024	Enoyl-CoA hydratase
NEJAP_RS06865	COG4221	oxidoreductase activity
NEJAP_RS06870	COG0546	phosphoglycolate phosphatase activity
NEJAP_RS06880	COG0424	maF-like protein
NEJAP_RS06885	COG1399	metal-binding, possibly nucleic acid-binding protein
NEJAP_RS06890	COG0333	Belongs to the bacterial ribosomal protein bL32 family
NEJAP_RS06895	COG0416	fatty acid biosynthetic process
NEJAP_RS06910	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NEJAP_RS06915	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NEJAP_RS06920	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NEJAP_RS06925	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
NEJAP_RS06930	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
NEJAP_RS06945	COG0084	hydrolase, TatD family'
NEJAP_RS06955	COG0039	L-malate dehydrogenase activity
NEJAP_RS06960	COG0835	chemotaxis
NEJAP_RS06965	COG2920	part of a sulfur-relay system
NEJAP_RS06980	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
NEJAP_RS06985	COG0670	Belongs to the BI1 family
NEJAP_RS06990	COG0564	pseudouridine synthase activity
NEJAP_RS06995	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
NEJAP_RS07000	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
NEJAP_RS07010	COG2084	Dehydrogenase
NEJAP_RS07025	COG0583	DNA-binding transcription factor activity
NEJAP_RS07040	COG0322	excinuclease ABC activity
NEJAP_RS07290	COG1802	Transcriptional regulator
NEJAP_RS07290	COG4626	Terminase
NEJAP_RS07295	COG4695	Portal protein
NEJAP_RS07385	COG1426	Protein conserved in bacteria
NEJAP_RS07450	COG2204	response regulator
NEJAP_RS07485	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NEJAP_RS07505	COG4935	Belongs to the peptidase S8 family
NEJAP_RS07505	COG1404	Belongs to the peptidase S8 family
NEJAP_RS07590	COG0850	regulation of cytokinetic process
NEJAP_RS07600	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
NEJAP_RS07615	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
NEJAP_RS07620	COG0066	3-isopropylmalate dehydratase activity
NEJAP_RS07625	COG0473	3-isopropylmalate dehydrogenase activity
NEJAP_RS07635	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
NEJAP_RS07645	COG0101	tRNA pseudouridine synthase activity
NEJAP_RS07650	COG0135	phosphoribosylanthranilate isomerase activity
NEJAP_RS07655	COG0133	tryptophan synthase activity
NEJAP_RS07660	COG0159	tryptophan synthase activity
NEJAP_RS07665	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
NEJAP_RS07670	COG0285	dihydrofolate synthase activity
NEJAP_RS07680	COG1286	toxin biosynthetic process
NEJAP_RS07710	COG1355	regulation of microtubule-based process
NEJAP_RS07725	COG1451	nucleotide metabolic process
NEJAP_RS07750	COG1802	Transcriptional regulator
NEJAP_RS07755	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
NEJAP_RS07760	COG0372	Belongs to the citrate synthase family
NEJAP_RS07765	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
NEJAP_RS07780	COG0552	protein localization to endoplasmic reticulum
NEJAP_RS07790	COG2255	four-way junction helicase activity
NEJAP_RS07815	COG0823	Involved in the tonB-independent uptake of proteins
NEJAP_RS07820	COG2885	chlorophyll binding
NEJAP_RS07825	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
NEJAP_RS07830	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
NEJAP_RS07835	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
NEJAP_RS07840	COG0390	transport system, permease component
NEJAP_RS07845	COG2022	thiamine diphosphate biosynthetic process
NEJAP_RS07855	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
NEJAP_RS07860	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NEJAP_RS07865	COG0686	Belongs to the AlaDH PNT family
NEJAP_RS07875	COG0280	phosphate acetyltransferase
NEJAP_RS07885	COG2197	response regulator
NEJAP_RS07890	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
NEJAP_RS07900	COG0589	response to stress
NEJAP_RS07905	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
NEJAP_RS07905	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
NEJAP_RS07910	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
NEJAP_RS07910	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
NEJAP_RS07915	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
NEJAP_RS07925	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
NEJAP_RS07940	COG2176	DNA-directed DNA polymerase activity
NEJAP_RS07955	COG2207	Transcriptional regulator
NEJAP_RS07980	COG1846	Transcriptional regulator
NEJAP_RS07990	COG0778	Nitroreductase
NEJAP_RS07995	COG2264	protein methyltransferase activity
NEJAP_RS08020	COG2095	MarC family integral membrane protein
NEJAP_RS08035	COG3214	Protein conserved in bacteria
NEJAP_RS08040	COG2824	Alkylphosphonate utilization operon protein PhnA
NEJAP_RS08060	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
NEJAP_RS08065	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
NEJAP_RS08070	COG0583	DNA-binding transcription factor activity
NEJAP_RS08075	COG0076	glutamate decarboxylase activity
NEJAP_RS08085	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NEJAP_RS08095	COG1414	Transcriptional regulator
NEJAP_RS08115	COG0589	response to stress
NEJAP_RS08125	COG1609	Transcriptional regulator
NEJAP_RS08150	COG1012	belongs to the aldehyde dehydrogenase family
NEJAP_RS08155	COG0318	PFAM AMP-dependent synthetase and ligase
NEJAP_RS08220	COG0730	response to heat
NEJAP_RS08230	COG0251	oxidation-reduction process
NEJAP_RS08235	COG2515	1-aminocyclopropane-1-carboxylate deaminase
NEJAP_RS08255	COG2267	carboxylic ester hydrolase activity
NEJAP_RS08260	COG0243	molybdopterin cofactor binding
NEJAP_RS08265	COG0437	4 iron, 4 sulfur cluster binding
NEJAP_RS08275	COG1012	belongs to the aldehyde dehydrogenase family
NEJAP_RS08300	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NEJAP_RS08305	COG0812	UDP-N-acetylmuramate dehydrogenase activity
NEJAP_RS08310	COG0840	transmembrane signaling receptor activity
NEJAP_RS08320	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
NEJAP_RS08325	COG0564	pseudouridine synthase activity
NEJAP_RS08360	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
NEJAP_RS08365	COG1199	ATP-dependent helicase activity
NEJAP_RS08380	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
NEJAP_RS08415	COG2890	protein-(glutamine-N5) methyltransferase activity
NEJAP_RS08420	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
NEJAP_RS08425	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
NEJAP_RS08430	COG1530	ribonuclease E activity
NEJAP_RS08455	COG1061	Type III restriction enzyme res subunit
NEJAP_RS08470	COG2226	methyltransferase
NEJAP_RS08480	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
NEJAP_RS08490	COG0215	cysteine-tRNA ligase activity
NEJAP_RS08505	COG2217	Heavy metal translocating P-type atpase
NEJAP_RS08510	COG0789	Transcriptional regulator
NEJAP_RS08535	COG0544	peptidyl-prolyl cis-trans isomerase activity
NEJAP_RS08540	COG0740	serine-type endopeptidase activity
NEJAP_RS08545	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
NEJAP_RS08560	COG2321	neutral zinc metallopeptidase
NEJAP_RS08570	COG4681	YaeQ
NEJAP_RS08575	COG0517	IMP dehydrogenase activity
NEJAP_RS08575	COG0516	GMP reductase activity
NEJAP_RS08610	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
NEJAP_RS08630	COG4232	protein-disulfide reductase activity
NEJAP_RS08645	COG0683	leucine binding
NEJAP_RS08665	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NEJAP_RS08665	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NEJAP_RS08680	COG0435	Glutathione S-transferase
NEJAP_RS08695	COG0513	Belongs to the DEAD box helicase family
NEJAP_RS08700	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
NEJAP_RS08720	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NEJAP_RS08735	COG2207	Transcriptional regulator
NEJAP_RS08740	COG0318	PFAM AMP-dependent synthetase and ligase
NEJAP_RS08755	COG4770	biotin carboxylase activity
NEJAP_RS08760	COG1024	Enoyl-CoA hydratase
NEJAP_RS08765	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NEJAP_RS08770	COG1960	acyl-CoA dehydrogenase activity
NEJAP_RS08775	COG0789	Transcriptional regulator
NEJAP_RS08805	COG0183	Belongs to the thiolase family
NEJAP_RS08810	COG4771	TonB-dependent receptor
NEJAP_RS08820	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
NEJAP_RS08825	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
NEJAP_RS08830	COG0583	DNA-binding transcription factor activity
NEJAP_RS08845	COG0679	Auxin Efflux Carrier
NEJAP_RS08865	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
NEJAP_RS08880	COG1960	acyl-CoA dehydrogenase activity
NEJAP_RS08885	COG1024	Enoyl-CoA hydratase
NEJAP_RS08890	COG1024	Enoyl-CoA hydratase
NEJAP_RS08925	COG2315	Protein conserved in bacteria
NEJAP_RS08950	COG0745	RESPONSE REGULATOR receiver
NEJAP_RS08960	COG0583	DNA-binding transcription factor activity
NEJAP_RS08965	COG0277	FAD linked oxidase domain protein
NEJAP_RS08965	COG0247	lactate metabolic process
NEJAP_RS08975	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
NEJAP_RS08990	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
NEJAP_RS08995	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
NEJAP_RS09000	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
NEJAP_RS09005	COG2721	sulfolactate sulfo-lyase activity
NEJAP_RS09010	COG0179	Fumarylacetoacetate (FAA) hydrolase
NEJAP_RS09015	COG1802	Transcriptional regulator
NEJAP_RS09020	COG1959	2 iron, 2 sulfur cluster binding
NEJAP_RS09030	COG0183	Belongs to the thiolase family
NEJAP_RS09035	COG2050	protein possibly involved in aromatic compounds catabolism
NEJAP_RS09040	COG1250	3-hydroxyacyl-CoA dehydrogenase
NEJAP_RS09045	COG1024	Enoyl-CoA hydratase
NEJAP_RS09050	COG1024	Enoyl-CoA hydratase
NEJAP_RS09060	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
NEJAP_RS09095	COG3327	negative regulation of DNA-templated transcription, initiation
NEJAP_RS09115	COG0589	response to stress
NEJAP_RS09125	COG0583	DNA-binding transcription factor activity
NEJAP_RS09140	COG0625	glutathione transferase activity
NEJAP_RS09145	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
NEJAP_RS09150	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
NEJAP_RS09160	COG2081	HI0933 family
NEJAP_RS09190	COG0454	-acetyltransferase
NEJAP_RS09200	COG4251	negative regulation of phosphorylation
NEJAP_RS09200	COG3706	GGDEF domain
NEJAP_RS09200	COG2203	Gaf domain
NEJAP_RS09200	COG5001	Diguanylate cyclase
NEJAP_RS09205	COG1944	ATP diphosphatase activity
NEJAP_RS09220	COG1804	L-carnitine dehydratase bile acid-inducible protein F
NEJAP_RS09225	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NEJAP_RS09240	COG2267	carboxylic ester hydrolase activity
NEJAP_RS09245	COG4566	intracellular signal transduction
NEJAP_RS09250	COG4191	Histidine kinase
NEJAP_RS09255	COG0318	PFAM AMP-dependent synthetase and ligase
NEJAP_RS09265	COG2200	EAL domain
NEJAP_RS09265	COG2199	diguanylate cyclase activity
NEJAP_RS09270	COG2030	dehydratase
NEJAP_RS09275	COG1960	acyl-CoA dehydrogenase activity
NEJAP_RS09280	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
NEJAP_RS09300	COG0435	Glutathione S-transferase
NEJAP_RS09315	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NEJAP_RS09330	COG0697	spore germination
NEJAP_RS09350	COG0583	DNA-binding transcription factor activity
NEJAP_RS09355	COG2084	Dehydrogenase
NEJAP_RS09365	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
NEJAP_RS09385	COG0174	glutamine synthetase
NEJAP_RS09415	COG0318	PFAM AMP-dependent synthetase and ligase
NEJAP_RS09420	COG4206	TonB-dependent receptor
NEJAP_RS09435	COG1797	cobyrinic acid a,c-diamide synthase activity
NEJAP_RS09440	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
NEJAP_RS09450	COG1492	cobalamin metabolic process
NEJAP_RS09460	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
NEJAP_RS09470	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
NEJAP_RS09490	COG1049	propionate catabolic process, 2-methylcitrate cycle
NEJAP_RS09520	COG0840	transmembrane signaling receptor activity
NEJAP_RS09540	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NEJAP_RS09545	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
NEJAP_RS09550	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NEJAP_RS09555	COG3706	GGDEF domain
NEJAP_RS09570	COG3706	GGDEF domain
NEJAP_RS09585	COG1280	lysine exporter protein (LysE YggA)
NEJAP_RS09595	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NEJAP_RS09600	COG1252	NADH dehydrogenase
NEJAP_RS09605	COG1132	(ABC) transporter
NEJAP_RS09625	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
NEJAP_RS09645	COG3383	formate dehydrogenase (NAD+) activity
NEJAP_RS09650	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
NEJAP_RS09665	COG1410	methionine synthase
NEJAP_RS09665	COG0646	methionine synthase
NEJAP_RS09685	COG0189	ligase activity
NEJAP_RS09685	COG1181	Belongs to the D-alanine--D-alanine ligase family
NEJAP_RS09685	COG2918	glutathione biosynthetic process
NEJAP_RS09720	COG5642	Protein of unknown function (DUF2384)
NEJAP_RS09810	COG0826	peptidase U32
NEJAP_RS09825	COG0604	alcohol dehydrogenase
NEJAP_RS09835	COG1846	Transcriptional regulator
NEJAP_RS09850	COG1917	Cupin 2, conserved barrel domain protein
NEJAP_RS09870	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
NEJAP_RS09875	COG0583	DNA-binding transcription factor activity
NEJAP_RS09895	COG2358	TRAP transporter, solute receptor (TAXI family
NEJAP_RS09910	COG2902	Dehydrogenase
NEJAP_RS09930	COG3437	response regulator, receiver
NEJAP_RS09930	COG0784	Response regulator, receiver
NEJAP_RS10005	COG3586	endonuclease activity
NEJAP_RS10015	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
NEJAP_RS10025	COG0557	exoribonuclease II activity
NEJAP_RS10030	COG0210	DNA helicase
NEJAP_RS10035	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
NEJAP_RS10045	COG1283	sodium-dependent phosphate transmembrane transporter activity
NEJAP_RS10050	COG0306	phosphate transporter
NEJAP_RS10075	COG1846	Transcriptional regulator
NEJAP_RS10080	COG3384	dioxygenase
NEJAP_RS10085	COG2814	Major facilitator Superfamily
NEJAP_RS10095	COG1741	Belongs to the pirin family
NEJAP_RS10100	COG1335	isochorismatase
NEJAP_RS10160	COG1012	belongs to the aldehyde dehydrogenase family
NEJAP_RS10180	COG3971	2-oxopent-4-enoate hydratase activity
NEJAP_RS10185	COG2204	response regulator
NEJAP_RS10200	COG2197	response regulator
NEJAP_RS10225	COG0419	ATPase involved in DNA repair
NEJAP_RS10230	COG0420	3'-5' exonuclease activity
NEJAP_RS10240	COG0300	oxidoreductase activity
NEJAP_RS10260	COG0179	Fumarylacetoacetate (FAA) hydrolase
NEJAP_RS10265	COG0346	lactoylglutathione lyase activity
NEJAP_RS10290	COG3706	GGDEF domain
NEJAP_RS10300	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
NEJAP_RS10310	COG4191	Histidine kinase
NEJAP_RS10325	COG1295	ribonuclease BN
NEJAP_RS10330	COG1393	Belongs to the ArsC family
NEJAP_RS10345	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NEJAP_RS10350	COG0583	DNA-binding transcription factor activity
NEJAP_RS10375	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
NEJAP_RS10385	COG2814	Major facilitator Superfamily
NEJAP_RS10390	COG5001	Diguanylate cyclase
NEJAP_RS10395	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
NEJAP_RS10400	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
NEJAP_RS10405	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
NEJAP_RS10410	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
NEJAP_RS10415	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
NEJAP_RS10420	COG0531	amino acid
NEJAP_RS10420	COG1674	ftsk spoiiie
NEJAP_RS10430	COG0492	ferredoxin-NADP+ reductase activity
NEJAP_RS10435	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
NEJAP_RS10440	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
NEJAP_RS10445	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
NEJAP_RS10450	COG0542	response to heat
NEJAP_RS10455	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
NEJAP_RS10460	COG1278	Cold shock
NEJAP_RS10470	COG1187	pseudouridine synthase activity
NEJAP_RS10505	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
NEJAP_RS10510	COG0314	molybdopterin synthase activity
NEJAP_RS10520	COG0482	sulfurtransferase activity
NEJAP_RS10525	COG2915	High frequency lysogenization protein hflD homolog
NEJAP_RS10540	COG1742	UPF0060 membrane protein
NEJAP_RS10565	COG2850	peptidyl-arginine hydroxylation
NEJAP_RS10595	COG0840	transmembrane signaling receptor activity
NEJAP_RS10610	COG1942	4-Oxalocrotonate Tautomerase
NEJAP_RS10630	COG0583	DNA-binding transcription factor activity
NEJAP_RS10635	COG0697	spore germination
NEJAP_RS10660	COG1024	Enoyl-CoA hydratase
NEJAP_RS10690	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
NEJAP_RS10720	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
NEJAP_RS10730	COG1804	L-carnitine dehydratase bile acid-inducible protein F
NEJAP_RS10740	COG1794	racemase activity, acting on amino acids and derivatives
NEJAP_RS10745	COG0583	DNA-binding transcription factor activity
NEJAP_RS10760	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NEJAP_RS10775	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
NEJAP_RS10780	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
NEJAP_RS10780	COG0316	Belongs to the HesB IscA family
NEJAP_RS10785	COG0475	glutathione-regulated potassium exporter activity
NEJAP_RS10785	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
NEJAP_RS10795	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NEJAP_RS10800	COG0564	pseudouridine synthase activity
NEJAP_RS10805	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NEJAP_RS10815	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NEJAP_RS10820	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
NEJAP_RS10830	COG0425	Belongs to the sulfur carrier protein TusA family
NEJAP_RS10845	COG2703	oxygen carrier activity
NEJAP_RS10850	COG1309	transcriptional regulator
NEJAP_RS10855	COG0133	tryptophan synthase activity
NEJAP_RS10860	COG0159	tryptophan synthase activity
NEJAP_RS10875	COG0789	Transcriptional regulator
NEJAP_RS10895	COG3220	belongs to the UPF0276 family
NEJAP_RS10905	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NEJAP_RS10910	COG2962	Rard protein
NEJAP_RS10925	COG1054	Belongs to the UPF0176 family
NEJAP_RS10945	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
NEJAP_RS10960	COG0628	permease
NEJAP_RS10970	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
NEJAP_RS10975	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
NEJAP_RS11010	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
NEJAP_RS11015	COG1278	Cold shock
NEJAP_RS11030	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
NEJAP_RS11035	COG2835	tetraacyldisaccharide 4'-kinase activity
NEJAP_RS11040	COG1663	tetraacyldisaccharide 4'-kinase activity
NEJAP_RS11050	COG0811	peptide transport
NEJAP_RS11055	COG2333	competence protein COMEC
NEJAP_RS11055	COG0658	competence protein
NEJAP_RS11090	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NEJAP_RS11100	COG1477	protein flavinylation
NEJAP_RS11105	COG2871	sodium ion transport
NEJAP_RS11110	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
NEJAP_RS11115	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
NEJAP_RS11125	COG1805	sodium ion transport
NEJAP_RS11130	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
NEJAP_RS11140	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
NEJAP_RS11150	COG0668	transmembrane transport
NEJAP_RS11155	COG1472	Belongs to the glycosyl hydrolase 3 family
NEJAP_RS11160	COG1376	ErfK ybiS ycfS ynhG family protein
NEJAP_RS11170	COG0616	signal peptide processing
NEJAP_RS11180	COG2816	NAD+ diphosphatase activity
NEJAP_RS11185	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
NEJAP_RS11190	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
NEJAP_RS11195	COG0328	RNA-DNA hybrid ribonuclease activity
NEJAP_RS11205	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NEJAP_RS11220	COG4166	transmembrane transport
NEJAP_RS11225	COG4174	ABC transporter (Permease)
NEJAP_RS11230	COG4239	(ABC) transporter, permease
NEJAP_RS11235	COG4172	Belongs to the ABC transporter superfamily
NEJAP_RS11245	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
NEJAP_RS11250	COG0217	transcriptional regulatory protein
NEJAP_RS11255	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
NEJAP_RS11275	COG3850	Histidine kinase
NEJAP_RS11275	COG3437	response regulator, receiver
NEJAP_RS11275	COG2205	protein histidine kinase activity
NEJAP_RS11275	COG4999	Histidine kinase
NEJAP_RS11285	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NEJAP_RS11305	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NEJAP_RS11335	COG3706	GGDEF domain
NEJAP_RS11345	COG0546	phosphoglycolate phosphatase activity
NEJAP_RS11360	COG0308	aminopeptidase N
NEJAP_RS11375	COG0705	Rhomboid family
NEJAP_RS11380	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
NEJAP_RS11385	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
NEJAP_RS11390	COG2515	1-aminocyclopropane-1-carboxylate deaminase
NEJAP_RS11410	COG2818	Glycosylase
NEJAP_RS11415	COG0436	Aminotransferase
NEJAP_RS11425	COG1639	'signal transduction protein
NEJAP_RS11440	COG0501	Belongs to the peptidase M48B family
NEJAP_RS11450	COG0708	Exodeoxyribonuclease III
NEJAP_RS11460	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NEJAP_RS11465	COG0640	Transcriptional regulator
NEJAP_RS11470	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NEJAP_RS11470	COG1042	CoA-binding domain protein
NEJAP_RS11470	COG0045	succinate-CoA ligase (ADP-forming) activity
NEJAP_RS11485	COG1280	lysine exporter protein (LysE YggA)
NEJAP_RS11490	COG3122	Protein conserved in bacteria
NEJAP_RS11500	COG4991	sh3 domain protein
NEJAP_RS11520	COG3101	peptidyl-lysine hydroxylation
NEJAP_RS11530	COG0737	Belongs to the 5'-nucleotidase family
NEJAP_RS11540	COG3258	Cytochrome c
NEJAP_RS11570	COG1024	Enoyl-CoA hydratase
NEJAP_RS11580	COG0037	tRNA processing
NEJAP_RS11590	COG1944	ATP diphosphatase activity
NEJAP_RS11630	COG0513	Belongs to the DEAD box helicase family
NEJAP_RS11635	COG3133	Outer membrane lipoprotein
NEJAP_RS11650	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
NEJAP_RS11655	COG0702	epimerase
NEJAP_RS11660	COG2855	membrane
NEJAP_RS11680	COG4286	Uncharacterised protein family (UPF0160)
NEJAP_RS11705	COG1280	lysine exporter protein (LysE YggA)
NEJAP_RS11740	COG0271	Belongs to the BolA IbaG family
NEJAP_RS11775	COG0004	ammonium transporteR
NEJAP_RS11780	COG0116	Belongs to the methyltransferase superfamily
NEJAP_RS11780	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
NEJAP_RS11785	COG3130	regulation of translation
NEJAP_RS11805	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
NEJAP_RS11810	COG1090	epimerase
NEJAP_RS11815	COG0307	riboflavin synthase, alpha
NEJAP_RS11850	COG1605	Chorismate mutase
NEJAP_RS11850	COG0077	Prephenate dehydratase
NEJAP_RS11855	COG2823	Periplasmic or secreted lipoprotein
NEJAP_RS11855	COG1652	LysM domain
NEJAP_RS11865	COG2326	polyphosphate kinase activity
NEJAP_RS11875	COG0513	Belongs to the DEAD box helicase family
NEJAP_RS11890	COG0733	neurotransmitter:sodium symporter activity
NEJAP_RS11895	COG0840	transmembrane signaling receptor activity
NEJAP_RS11905	COG3321	synthase
NEJAP_RS11905	COG1028	Short-chain dehydrogenase reductase Sdr
NEJAP_RS11905	COG0604	alcohol dehydrogenase
NEJAP_RS11910	COG0156	8-amino-7-oxononanoate synthase activity
NEJAP_RS11920	COG1368	sulfuric ester hydrolase activity
NEJAP_RS11925	COG1028	Short-chain dehydrogenase reductase Sdr
NEJAP_RS11930	COG1218	3'(2'),5'-bisphosphate nucleotidase
NEJAP_RS11955	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
NEJAP_RS11985	COG1309	transcriptional regulator
NEJAP_RS11990	COG4175	Glycine betaine
NEJAP_RS12010	COG1012	belongs to the aldehyde dehydrogenase family
NEJAP_RS12020	COG0583	DNA-binding transcription factor activity
NEJAP_RS12025	COG0277	FAD linked oxidase domain protein
NEJAP_RS12030	COG0277	FAD linked oxidase domain protein
NEJAP_RS12035	COG0247	lactate metabolic process
NEJAP_RS12065	COG2205	protein histidine kinase activity
NEJAP_RS12065	COG0784	Response regulator, receiver
NEJAP_RS12080	COG3132	Protein of unknown function, DUF480
NEJAP_RS12085	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
NEJAP_RS12090	COG0302	gtp cyclohydrolase
NEJAP_RS12100	COG0604	alcohol dehydrogenase
NEJAP_RS12110	COG0415	Belongs to the DNA photolyase family
NEJAP_RS12120	COG3806	Anti-sigma factor
NEJAP_RS12125	COG1595	DNA-templated transcription, initiation
NEJAP_RS12130	COG1233	COG1233 Phytoene dehydrogenase and related
NEJAP_RS12140	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
NEJAP_RS12160	COG1028	Short-chain dehydrogenase reductase Sdr
NEJAP_RS12175	COG2814	Major facilitator Superfamily
NEJAP_RS12185	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
NEJAP_RS12200	COG0247	lactate metabolic process
NEJAP_RS12200	COG2181	nitrate reductase activity
NEJAP_RS12205	COG0446	pyridine nucleotide-disulphide oxidoreductase
NEJAP_RS12205	COG1902	pentaerythritol trinitrate reductase activity
NEJAP_RS12225	COG4628	conserved protein (DUF2132)
NEJAP_RS12260	COG1854	S-ribosylhomocysteine lyase activity
NEJAP_RS12265	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
NEJAP_RS12280	COG2995	paraquat-inducible protein a
NEJAP_RS12285	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
NEJAP_RS12300	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NEJAP_RS12345	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
NEJAP_RS12350	COG1053	succinate dehydrogenase
NEJAP_RS12355	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
NEJAP_RS12375	COG1238	metal cluster binding
NEJAP_RS12380	COG0514	ATP-dependent DNA helicase (RecQ)
NEJAP_RS12400	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NEJAP_RS12410	COG0840	transmembrane signaling receptor activity
NEJAP_RS12415	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
NEJAP_RS12430	COG0217	transcriptional regulatory protein
NEJAP_RS12435	COG2989	Protein conserved in bacteria
NEJAP_RS12515	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NEJAP_RS12520	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
NEJAP_RS12525	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NEJAP_RS12530	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
NEJAP_RS12540	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
NEJAP_RS12565	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
NEJAP_RS12570	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
NEJAP_RS12575	COG0235	Class ii aldolase
NEJAP_RS12600	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
NEJAP_RS12605	COG0418	dihydroorotase activity
NEJAP_RS12610	COG3437	response regulator, receiver
NEJAP_RS12615	COG0488	(ABC) transporter
NEJAP_RS12620	COG1278	Cold shock
NEJAP_RS12625	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
NEJAP_RS12630	COG0583	DNA-binding transcription factor activity
NEJAP_RS12640	COG1902	pentaerythritol trinitrate reductase activity
NEJAP_RS12645	COG3154	lipid carrier protein
NEJAP_RS12650	COG0826	peptidase U32
NEJAP_RS12655	COG0826	peptidase U32
NEJAP_RS12660	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
NEJAP_RS12670	COG4191	Histidine kinase
NEJAP_RS12680	COG2204	response regulator
NEJAP_RS12685	COG5001	Diguanylate cyclase
NEJAP_RS12685	COG3300	MHYT domain
NEJAP_RS12695	COG0745	RESPONSE REGULATOR receiver
NEJAP_RS12720	COG2207	Transcriptional regulator
NEJAP_RS12730	COG0579	oxidoreductase
NEJAP_RS12740	COG1802	Transcriptional regulator
NEJAP_RS12755	COG4172	Belongs to the ABC transporter superfamily
NEJAP_RS12760	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NEJAP_RS12770	COG0747	negative chemotaxis
NEJAP_RS12825	COG1132	(ABC) transporter
NEJAP_RS12875	COG0247	lactate metabolic process
NEJAP_RS12880	COG0277	FAD linked oxidase domain protein
NEJAP_RS12885	COG0277	FAD linked oxidase domain protein
NEJAP_RS12890	COG2832	Protein of unknown function (DUF454)
NEJAP_RS12915	COG1116	anion transmembrane transporter activity
NEJAP_RS12920	COG0251	oxidation-reduction process
NEJAP_RS12940	COG1917	Cupin 2, conserved barrel domain protein
NEJAP_RS12940	COG4977	sequence-specific DNA binding
NEJAP_RS12965	COG1132	(ABC) transporter
NEJAP_RS13015	COG0745	RESPONSE REGULATOR receiver
NEJAP_RS13020	COG5002	protein histidine kinase activity
NEJAP_RS13025	COG2304	oxidoreductase activity
NEJAP_RS13045	COG4191	Histidine kinase
NEJAP_RS13080	COG1804	L-carnitine dehydratase bile acid-inducible protein F
NEJAP_RS13090	COG2207	Transcriptional regulator
NEJAP_RS13095	COG1454	alcohol dehydrogenase
NEJAP_RS13100	COG1012	belongs to the aldehyde dehydrogenase family
NEJAP_RS13105	COG1960	acyl-CoA dehydrogenase activity
NEJAP_RS13120	COG0183	Belongs to the thiolase family
NEJAP_RS13125	COG1028	Short-chain dehydrogenase reductase Sdr
NEJAP_RS13130	COG0318	PFAM AMP-dependent synthetase and ligase
NEJAP_RS13195	COG0714	Associated with various cellular activities
NEJAP_RS13200	COG3119	arylsulfatase activity
NEJAP_RS13235	COG0556	nucleotide-excision repair
NEJAP_RS13240	COG0436	Aminotransferase
NEJAP_RS13250	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NEJAP_RS13255	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NEJAP_RS13260	COG1538	Outer membrane efflux protein
NEJAP_RS13275	COG0717	Belongs to the dCTP deaminase family
NEJAP_RS13280	COG0489	protein tyrosine kinase activity
NEJAP_RS13300	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NEJAP_RS13300	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NEJAP_RS13310	COG4597	amino acid ABC transporter
NEJAP_RS13315	COG0765	amino acid transport
NEJAP_RS13320	COG1126	abc transporter atp-binding protein
NEJAP_RS13330	COG0659	secondary active sulfate transmembrane transporter activity
NEJAP_RS13335	COG0590	tRNA wobble adenosine to inosine editing
NEJAP_RS13335	COG0037	tRNA processing
NEJAP_RS13340	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NEJAP_RS13370	COG2205	protein histidine kinase activity
NEJAP_RS13380	COG2204	response regulator
NEJAP_RS13385	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
NEJAP_RS13390	COG3530	Putative quorum-sensing-regulated virulence factor
NEJAP_RS13395	COG0500	methyltransferase
NEJAP_RS13400	COG1444	tRNA N-acetyltransferase activity
NEJAP_RS13420	COG0625	glutathione transferase activity
NEJAP_RS13425	COG1671	Belongs to the UPF0178 family
NEJAP_RS13445	COG0023	Translation Initiation Factor
NEJAP_RS13465	COG0456	acetyltransferase
NEJAP_RS13470	COG0778	Nitroreductase
NEJAP_RS13480	COG0842	Transport permease protein
NEJAP_RS13485	COG1131	(ABC) transporter
NEJAP_RS13495	COG2203	Gaf domain
NEJAP_RS13495	COG4251	negative regulation of phosphorylation
NEJAP_RS13495	COG5001	Diguanylate cyclase
NEJAP_RS13495	COG3706	GGDEF domain
NEJAP_RS13565	COG2391	methyltransferase activity
NEJAP_RS13575	COG1879	ABC-type sugar transport system periplasmic component
NEJAP_RS13595	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NEJAP_RS13610	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
NEJAP_RS13625	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
NEJAP_RS13635	COG0659	secondary active sulfate transmembrane transporter activity
NEJAP_RS13640	COG3901	Regulator of nitric oxide reductase transcription
NEJAP_RS13640	COG0348	domain, Protein
NEJAP_RS13655	COG0776	regulation of translation
NEJAP_RS13660	COG0072	phenylalanine-tRNA ligase activity
NEJAP_RS13665	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
NEJAP_RS13675	COG0291	Belongs to the bacterial ribosomal protein bL35 family
NEJAP_RS13680	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
NEJAP_RS13685	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
NEJAP_RS13690	COG2186	Transcriptional regulator
NEJAP_RS13695	COG0247	lactate metabolic process
NEJAP_RS13700	COG1139	Iron-sulfur cluster binding protein
NEJAP_RS13720	COG1739	Uncharacterized protein family UPF0029
NEJAP_RS13730	COG0583	DNA-binding transcription factor activity
NEJAP_RS13735	COG0702	epimerase
NEJAP_RS13750	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NEJAP_RS13760	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NEJAP_RS13760	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NEJAP_RS13765	COG0509	glycine decarboxylation via glycine cleavage system
NEJAP_RS13770	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
NEJAP_RS13775	COG1760	l-serine dehydratase
NEJAP_RS13780	COG1115	amino acid carrier protein
NEJAP_RS13785	COG0404	The glycine cleavage system catalyzes the degradation of glycine
NEJAP_RS13795	COG0417	DNA replication proofreading
NEJAP_RS13815	COG3425	synthase
NEJAP_RS13820	COG1304	FMN binding
NEJAP_RS13830	COG1538	Outer membrane efflux protein
NEJAP_RS13840	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NEJAP_RS13845	COG2274	protein secretion by the type I secretion system
NEJAP_RS13860	COG0137	argininosuccinate synthase activity
NEJAP_RS13870	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
NEJAP_RS13875	COG0450	alkyl hydroperoxide reductase
NEJAP_RS13880	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
NEJAP_RS13885	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NEJAP_RS13890	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
NEJAP_RS13895	COG0583	DNA-binding transcription factor activity
NEJAP_RS13905	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
NEJAP_RS13950	COG0517	IMP dehydrogenase activity
NEJAP_RS13950	COG0617	tRNA 3'-terminal CCA addition
NEJAP_RS13950	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
NEJAP_RS13955	COG0788	formyltetrahydrofolate deformylase activity
NEJAP_RS13960	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
NEJAP_RS13980	COG0716	FMN binding
NEJAP_RS13990	COG0523	cobalamin synthesis protein
NEJAP_RS14000	COG3706	GGDEF domain
NEJAP_RS14005	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
NEJAP_RS14005	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
NEJAP_RS14020	COG1522	sequence-specific DNA binding
NEJAP_RS14025	COG0405	Gamma-glutamyltransferase
NEJAP_RS14040	COG1902	pentaerythritol trinitrate reductase activity
NEJAP_RS14040	COG0446	pyridine nucleotide-disulphide oxidoreductase
NEJAP_RS14045	COG1250	3-hydroxyacyl-CoA dehydrogenase
NEJAP_RS14045	COG1024	Enoyl-CoA hydratase
NEJAP_RS14060	COG0826	peptidase U32
NEJAP_RS14065	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
NEJAP_RS14080	COG0006	proline dipeptidase activity
NEJAP_RS14085	COG0583	DNA-binding transcription factor activity
NEJAP_RS14090	COG2866	Carboxypeptidase
NEJAP_RS14095	COG4608	Belongs to the ABC transporter superfamily
NEJAP_RS14105	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NEJAP_RS14110	COG0601	transmembrane transport
NEJAP_RS14120	COG0459	protein refolding
NEJAP_RS14125	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
NEJAP_RS14135	COG1028	Short-chain dehydrogenase reductase Sdr
NEJAP_RS14140	COG2211	Major facilitator Superfamily
NEJAP_RS14155	COG1666	GTP binding
NEJAP_RS14165	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
NEJAP_RS14165	COG4932	domain protein
NEJAP_RS14165	COG3266	domain, Protein
NEJAP_RS14175	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NEJAP_RS14185	COG2326	polyphosphate kinase activity
NEJAP_RS14200	COG2096	Adenosyltransferase
NEJAP_RS14205	COG1639	'signal transduction protein
NEJAP_RS14215	COG0604	alcohol dehydrogenase
NEJAP_RS14220	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NEJAP_RS14235	COG0011	TIGRFAM Protein of
NEJAP_RS14240	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
NEJAP_RS14270	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NEJAP_RS14275	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
NEJAP_RS14280	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
NEJAP_RS14285	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NEJAP_RS14290	COG5007	Belongs to the BolA IbaG family
NEJAP_RS14305	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
NEJAP_RS14310	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
NEJAP_RS14315	COG1127	ABC transporter
NEJAP_RS14335	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
NEJAP_RS14340	COG1137	ATPase activity
NEJAP_RS14350	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
NEJAP_RS14360	COG1660	Displays ATPase and GTPase activities
NEJAP_RS14370	COG2239	Acts as a magnesium transporter
NEJAP_RS14375	COG3028	Belongs to the UPF0307 family
NEJAP_RS14390	COG1530	ribonuclease E activity
NEJAP_RS14400	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
NEJAP_RS14405	COG1792	Involved in formation and maintenance of cell shape
NEJAP_RS14410	COG1077	Cell shape determining protein MreB Mrl
NEJAP_RS14415	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NEJAP_RS14420	COG0154	amidase activity
NEJAP_RS14465	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NEJAP_RS14470	COG2165	general secretion pathway protein
NEJAP_RS14485	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NEJAP_RS14500	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
NEJAP_RS14505	COG0625	glutathione transferase activity
NEJAP_RS14515	COG3138	arginine N-succinyltransferase
NEJAP_RS14520	COG3138	arginine N-succinyltransferase
NEJAP_RS14525	COG1012	belongs to the aldehyde dehydrogenase family
NEJAP_RS14530	COG3724	N-succinylarginine dihydrolase activity
NEJAP_RS14545	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
NEJAP_RS14550	COG1469	GTP cyclohydrolase I activity
NEJAP_RS14555	COG0583	DNA-binding transcription factor activity
NEJAP_RS14560	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
NEJAP_RS14580	COG2384	SAM-dependent methyltransferase
NEJAP_RS14585	COG0488	(ABC) transporter
NEJAP_RS14610	COG1017	nitric oxide dioxygenase activity
NEJAP_RS14610	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NEJAP_RS14640	COG2318	DinB family
NEJAP_RS14650	COG0183	Belongs to the thiolase family
NEJAP_RS14655	COG1960	acyl-CoA dehydrogenase activity
NEJAP_RS14685	COG0583	DNA-binding transcription factor activity
NEJAP_RS14720	COG0303	'Molybdopterin
NEJAP_RS14725	COG0521	Mo-molybdopterin cofactor biosynthetic process
NEJAP_RS14735	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
NEJAP_RS14745	COG1115	amino acid carrier protein
NEJAP_RS14760	COG0288	reversible hydration of carbon dioxide
NEJAP_RS14765	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NEJAP_RS14770	COG2181	nitrate reductase activity
NEJAP_RS14775	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
NEJAP_RS14780	COG1140	nitrate reductase beta subunit
NEJAP_RS14785	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
NEJAP_RS14790	COG2223	nitrite transmembrane transporter activity
NEJAP_RS14800	COG3850	Histidine kinase
NEJAP_RS14805	COG2197	response regulator
NEJAP_RS14810	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
NEJAP_RS14830	COG5001	Diguanylate cyclase
NEJAP_RS14835	COG2223	nitrite transmembrane transporter activity
NEJAP_RS14885	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
NEJAP_RS14890	COG1801	Protein of unknown function DUF72
NEJAP_RS14905	COG2900	Belongs to the SlyX family
NEJAP_RS14910	COG2937	Belongs to the GPAT DAPAT family
NEJAP_RS14915	COG0742	ribosomal rna small subunit methyltransferase
NEJAP_RS14920	COG1968	undecaprenyl-diphosphatase activity
NEJAP_RS14925	COG1214	PFAM Peptidase M22, glycoprotease
NEJAP_RS14935	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
NEJAP_RS14940	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
NEJAP_RS14945	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
NEJAP_RS14960	COG0730	response to heat
NEJAP_RS14975	COG1573	uracil-dna glycosylase
NEJAP_RS14980	COG0625	glutathione transferase activity
NEJAP_RS15010	COG1187	pseudouridine synthase activity
NEJAP_RS15035	COG0840	transmembrane signaling receptor activity
NEJAP_RS15040	COG0583	DNA-binding transcription factor activity
NEJAP_RS15055	COG0477	Major facilitator Superfamily
NEJAP_RS15080	COG0625	glutathione transferase activity
NEJAP_RS15090	COG0583	DNA-binding transcription factor activity
NEJAP_RS15195	COG1280	lysine exporter protein (LysE YggA)
NEJAP_RS15205	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NEJAP_RS15210	COG0513	Belongs to the DEAD box helicase family
NEJAP_RS15225	COG0577	efflux transmembrane transporter activity
NEJAP_RS15230	COG4181	ATPase activity
NEJAP_RS15240	COG0745	RESPONSE REGULATOR receiver
NEJAP_RS15255	COG0429	hydrolase of the alpha beta-hydrolase fold
NEJAP_RS15330	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
NEJAP_RS15335	COG0010	Belongs to the arginase family
NEJAP_RS15340	COG1228	amidohydrolase
NEJAP_RS15345	COG2188	Transcriptional regulator
NEJAP_RS15360	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
NEJAP_RS15365	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
NEJAP_RS15380	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
NEJAP_RS15385	COG0511	ligase activity, forming carbon-carbon bonds
NEJAP_RS15395	COG2264	protein methyltransferase activity
NEJAP_RS15425	COG0151	Belongs to the GarS family
NEJAP_RS15460	COG0508	dehydrogenase complex catalyzes the overall conversion of
NEJAP_RS15465	COG2766	serine protein kinase
NEJAP_RS15470	COG2718	Belongs to the UPF0229 family
NEJAP_RS15475	COG2719	SpoVR family
NEJAP_RS15480	COG0537	adenosine 5'-monophosphoramidase activity
NEJAP_RS15490	COG1279	arginine transmembrane transporter activity
NEJAP_RS15500	COG0280	phosphate acetyltransferase
NEJAP_RS15505	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
NEJAP_RS15520	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NEJAP_RS15525	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
NEJAP_RS15530	COG0563	adenylate kinase activity
NEJAP_RS15535	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
NEJAP_RS15545	COG3956	TIGRFAM MazG family protein
NEJAP_RS15550	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NEJAP_RS15570	COG2154	pterin-4-alpha-carbinolamine dehydratase
NEJAP_RS15580	COG3448	diguanylate cyclase activity
NEJAP_RS15580	COG4175	Glycine betaine
NEJAP_RS15585	COG4176	ABC-type proline glycine betaine transport system permease component
NEJAP_RS15600	COG0736	holo-[acyl-carrier-protein] synthase activity
NEJAP_RS15605	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
NEJAP_RS15610	COG1381	Involved in DNA repair and RecF pathway recombination
NEJAP_RS15615	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
NEJAP_RS15620	COG0571	ribonuclease III activity
NEJAP_RS15630	COG0681	Belongs to the peptidase S26 family
NEJAP_RS15635	COG0481	GTPase activity
NEJAP_RS15640	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NEJAP_RS15645	COG3086	response to oxidative stress
NEJAP_RS15695	COG1160	GTP binding
NEJAP_RS15705	COG2976	Protein conserved in bacteria
NEJAP_RS15710	COG0124	histidyl-tRNA synthetase
NEJAP_RS15720	COG3063	Type IV pilus biogenesis stability protein PilW
NEJAP_RS15725	COG0820	rRNA (adenine-C2-)-methyltransferase activity
NEJAP_RS15730	COG0105	UTP biosynthetic process
NEJAP_RS15750	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
NEJAP_RS15790	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
NEJAP_RS15800	COG0330	HflC and HflK could
NEJAP_RS15805	COG0330	HflC and HflK could
NEJAP_RS15810	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
NEJAP_RS15815	COG1923	regulation of RNA biosynthetic process
NEJAP_RS15820	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
NEJAP_RS15825	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
NEJAP_RS15830	COG0860	N-Acetylmuramoyl-L-alanine amidase
NEJAP_RS15835	COG0802	atpase or kinase
NEJAP_RS15840	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
NEJAP_RS15840	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
NEJAP_RS15855	COG0714	Associated with various cellular activities
NEJAP_RS15865	COG2010	Cytochrome c
NEJAP_RS15870	COG0583	DNA-binding transcription factor activity
NEJAP_RS15875	COG0697	spore germination
NEJAP_RS15885	COG1845	cytochrome c oxidase, subunit III
NEJAP_RS15890	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
NEJAP_RS15895	COG1162	GTPase activity
NEJAP_RS15910	COG0688	phosphatidylethanolamine metabolic process
NEJAP_RS15920	COG0840	transmembrane signaling receptor activity
NEJAP_RS15925	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
NEJAP_RS15935	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
NEJAP_RS15940	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
NEJAP_RS15960	COG3909	cytochrome
NEJAP_RS15965	COG0716	FMN binding
NEJAP_RS15985	COG2391	methyltransferase activity
NEJAP_RS15995	COG0795	lipopolysaccharide-transporting ATPase activity
NEJAP_RS16000	COG0795	lipopolysaccharide-transporting ATPase activity
NEJAP_RS16015	COG0525	valine-tRNA ligase activity
NEJAP_RS16030	COG1309	transcriptional regulator
NEJAP_RS16045	COG1335	isochorismatase
NEJAP_RS16050	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NEJAP_RS16075	COG2201	protein-glutamate methylesterase activity
NEJAP_RS16080	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
NEJAP_RS16090	COG0840	transmembrane signaling receptor activity
NEJAP_RS16095	COG0835	chemotaxis
NEJAP_RS16100	COG2198	Histidine kinase
NEJAP_RS16100	COG0643	Histidine kinase
NEJAP_RS16105	COG0745	RESPONSE REGULATOR receiver
NEJAP_RS16120	COG1047	Peptidyl-prolyl cis-trans
NEJAP_RS16130	COG0259	pyridoxamine-phosphate oxidase activity
NEJAP_RS16140	COG2995	paraquat-inducible protein a
NEJAP_RS16145	COG3008	intermembrane lipid transfer
NEJAP_RS16185	COG0436	Aminotransferase
NEJAP_RS16190	COG1393	Belongs to the ArsC family
NEJAP_RS16200	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NEJAP_RS16205	COG2226	methyltransferase
NEJAP_RS16240	COG0729	surface antigen
NEJAP_RS16245	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NEJAP_RS16270	COG0583	DNA-binding transcription factor activity
NEJAP_RS16285	COG2095	MarC family integral membrane protein
NEJAP_RS16295	COG1960	acyl-CoA dehydrogenase activity
NEJAP_RS16325	COG0791	NLP P60 protein
NEJAP_RS16340	COG0513	Belongs to the DEAD box helicase family
NEJAP_RS16350	COG0277	FAD linked oxidase domain protein
NEJAP_RS16355	COG0678	peroxiredoxin activity
NEJAP_RS16355	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
NEJAP_RS16365	COG1970	mechanosensitive ion channel activity
NEJAP_RS16370	COG0330	HflC and HflK could
NEJAP_RS16385	COG0513	Belongs to the DEAD box helicase family
NEJAP_RS16450	COG0583	DNA-binding transcription factor activity
NEJAP_RS16465	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
NEJAP_RS16475	COG0686	Belongs to the AlaDH PNT family
NEJAP_RS16480	COG0183	Belongs to the thiolase family
NEJAP_RS16485	COG1024	Enoyl-CoA hydratase
NEJAP_RS16485	COG1250	3-hydroxyacyl-CoA dehydrogenase
NEJAP_RS16505	COG1024	Enoyl-CoA hydratase
NEJAP_RS16530	COG1960	acyl-CoA dehydrogenase activity
NEJAP_RS16540	COG0840	transmembrane signaling receptor activity
NEJAP_RS16545	COG0753	catalase activity
NEJAP_RS16555	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NEJAP_RS16555	COG5549	protein import
NEJAP_RS16570	COG0668	transmembrane transport
NEJAP_RS16580	COG0589	response to stress
NEJAP_RS16590	COG4447	cellulose binding
NEJAP_RS16610	COG0411	ABC transporter
NEJAP_RS16670	COG1027	Aspartate ammonia-lyase
NEJAP_RS16675	COG0252	asparaginase activity
NEJAP_RS16680	COG1832	CoA-binding protein
NEJAP_RS16685	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
NEJAP_RS16690	COG2890	protein-(glutamine-N5) methyltransferase activity
NEJAP_RS16695	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
NEJAP_RS16700	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
NEJAP_RS16710	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
NEJAP_RS16720	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
NEJAP_RS16725	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
NEJAP_RS16730	COG0193	aminoacyl-tRNA hydrolase activity
NEJAP_RS16735	COG0012	GTP binding
NEJAP_RS16755	COG2200	EAL domain
NEJAP_RS16760	COG3830	Belongs to the UPF0237 family
NEJAP_RS16760	COG0560	Phosphoserine phosphatase
NEJAP_RS16765	COG0557	exoribonuclease II activity
NEJAP_RS16780	COG1862	Preprotein translocase
NEJAP_RS16785	COG0343	queuine tRNA-ribosyltransferase activity
NEJAP_RS16790	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
NEJAP_RS16840	COG0477	Major facilitator Superfamily
NEJAP_RS16845	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
NEJAP_RS16850	COG0531	amino acid
NEJAP_RS16860	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NEJAP_RS16865	COG1177	transmembrane transport
NEJAP_RS16870	COG1176	ABC-type spermidine putrescine transport system, permease component I
NEJAP_RS16875	COG3842	ATPase activity
NEJAP_RS16880	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
NEJAP_RS16890	COG1012	belongs to the aldehyde dehydrogenase family
NEJAP_RS16895	COG5001	Diguanylate cyclase
NEJAP_RS16895	COG4251	negative regulation of phosphorylation
NEJAP_RS16895	COG2203	Gaf domain
NEJAP_RS16895	COG3706	GGDEF domain
NEJAP_RS16905	COG1132	(ABC) transporter
NEJAP_RS16940	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
NEJAP_RS16945	COG1119	ATPase activity
NEJAP_RS16950	COG5001	Diguanylate cyclase
NEJAP_RS16950	COG5002	protein histidine kinase activity
NEJAP_RS16965	COG0840	transmembrane signaling receptor activity
NEJAP_RS16975	COG2130	NADP-dependent
NEJAP_RS16980	COG0693	protein deglycase activity
NEJAP_RS16990	COG1028	Short-chain dehydrogenase reductase Sdr
NEJAP_RS16995	COG2239	Acts as a magnesium transporter
NEJAP_RS17005	COG4771	TonB-dependent receptor
NEJAP_RS17015	COG5002	protein histidine kinase activity
NEJAP_RS17015	COG2205	protein histidine kinase activity
NEJAP_RS17015	COG0784	Response regulator, receiver
NEJAP_RS17065	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NEJAP_RS17075	COG0676	glucose-6-phosphate 1-epimerase activity
NEJAP_RS17100	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
NEJAP_RS17105	COG0351	phosphomethylpyrimidine kinase
NEJAP_RS17115	COG0671	phosphoesterase, PA-phosphatase related
NEJAP_RS17120	COG2267	carboxylic ester hydrolase activity
NEJAP_RS17125	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
NEJAP_RS17130	COG0697	spore germination
NEJAP_RS17135	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NEJAP_RS17145	COG0227	Belongs to the bacterial ribosomal protein bL28 family
NEJAP_RS17155	COG2003	Belongs to the UPF0758 family
NEJAP_RS17160	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
NEJAP_RS17165	COG0756	dUTP diphosphatase activity
NEJAP_RS17175	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
NEJAP_RS17180	COG1309	transcriptional regulator
NEJAP_RS17185	COG2861	carbohydrate metabolic process
NEJAP_RS17190	COG0793	Belongs to the peptidase S41A family
NEJAP_RS17195	COG4942	peptidase
NEJAP_RS17200	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
NEJAP_RS17205	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NEJAP_RS17215	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
NEJAP_RS17225	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
NEJAP_RS17235	COG3852	Histidine kinase
NEJAP_RS17245	COG1217	gtp-binding protein TYPA
NEJAP_RS17255	COG1490	D-aminoacyl-tRNA deacylase activity
NEJAP_RS17260	COG3148	PFAM DTW domain containing protein
NEJAP_RS17270	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
NEJAP_RS17275	COG1763	Mo-molybdopterin cofactor biosynthetic process
NEJAP_RS17300	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
NEJAP_RS17305	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
NEJAP_RS17310	COG1183	phosphatidylcholine synthase activity
NEJAP_RS17315	COG0583	DNA-binding transcription factor activity
NEJAP_RS17330	COG0028	Belongs to the TPP enzyme family
NEJAP_RS17340	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
NEJAP_RS17350	COG0463	Glycosyl transferase, family 2
NEJAP_RS17370	COG0745	RESPONSE REGULATOR receiver
NEJAP_RS17380	COG1918	ferrous iron import across plasma membrane
NEJAP_RS17380	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
NEJAP_RS17395	COG1063	alcohol dehydrogenase
NEJAP_RS17400	COG0156	8-amino-7-oxononanoate synthase activity
NEJAP_RS17410	COG1522	sequence-specific DNA binding
NEJAP_RS17430	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
NEJAP_RS17480	COG1047	Peptidyl-prolyl cis-trans
NEJAP_RS17495	COG0196	riboflavin kinase activity
NEJAP_RS17500	COG0728	peptidoglycan biosynthetic process
NEJAP_RS17505	COG0268	Binds directly to 16S ribosomal RNA
NEJAP_RS17510	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
NEJAP_RS17515	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
NEJAP_RS17525	COG0261	This protein binds to 23S rRNA in the presence of protein L20
NEJAP_RS17530	COG0142	geranyltranstransferase activity
NEJAP_RS17535	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
NEJAP_RS17550	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
NEJAP_RS17555	COG0315	cyclic pyranopterin monophosphate synthase activity
NEJAP_RS17565	COG0303	'Molybdopterin
NEJAP_RS17570	COG3094	Invasion gene expression up-regulator, SirB
NEJAP_RS17575	COG1091	dTDP-4-dehydrorhamnose reductase activity
NEJAP_RS17590	COG0203	ribosomal protein L17
NEJAP_RS17595	COG0202	RNA polymerase activity
NEJAP_RS17600	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
NEJAP_RS17605	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
NEJAP_RS17610	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
NEJAP_RS17615	COG0257	Belongs to the bacterial ribosomal protein bL36 family
NEJAP_RS17625	COG0200	Binds to the 23S rRNA
NEJAP_RS17630	COG1841	ribosomal large subunit assembly
NEJAP_RS17635	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
NEJAP_RS17640	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
NEJAP_RS17645	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
NEJAP_RS17650	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
NEJAP_RS17655	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
NEJAP_RS17660	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
NEJAP_RS17665	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
NEJAP_RS17670	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
NEJAP_RS17675	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
NEJAP_RS17680	COG0255	Belongs to the universal ribosomal protein uL29 family
NEJAP_RS17685	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
NEJAP_RS17690	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
NEJAP_RS17695	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
NEJAP_RS17700	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
NEJAP_RS17705	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
NEJAP_RS17710	COG0089	rRNA binding
NEJAP_RS17715	COG0088	Forms part of the polypeptide exit tunnel
NEJAP_RS17720	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
NEJAP_RS17730	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
NEJAP_RS17735	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
NEJAP_RS17740	COG0049	tRNA binding
NEJAP_RS17745	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
NEJAP_RS17755	COG0085	RNA polymerase activity
NEJAP_RS17760	COG0222	ribosome binding
NEJAP_RS17765	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
NEJAP_RS17770	COG0081	regulation of translation
NEJAP_RS17775	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
NEJAP_RS17795	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
NEJAP_RS17825	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
NEJAP_RS17830	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
NEJAP_RS17830	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
NEJAP_RS17845	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
NEJAP_RS17855	COG0730	response to heat
NEJAP_RS17870	COG0494	nUDIX hydrolase
NEJAP_RS17895	COG0667	Aldo Keto reductase
NEJAP_RS17900	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
NEJAP_RS17905	COG0509	glycine decarboxylation via glycine cleavage system
NEJAP_RS17910	COG0404	The glycine cleavage system catalyzes the degradation of glycine
NEJAP_RS17915	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NEJAP_RS17920	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NEJAP_RS17925	COG0006	proline dipeptidase activity
NEJAP_RS17930	COG3079	Belongs to the UPF0149 family
NEJAP_RS17950	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
NEJAP_RS17965	COG2261	transglycosylase associated protein
NEJAP_RS17980	COG0181	hydroxymethylbilane synthase activity
NEJAP_RS17990	COG2959	enzyme of heme biosynthesis
NEJAP_RS17995	COG3071	HemY protein
NEJAP_RS18010	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
NEJAP_RS18030	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
NEJAP_RS18035	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
NEJAP_RS18040	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
NEJAP_RS18045	COG1011	Hydrolase
NEJAP_RS18050	COG0494	nUDIX hydrolase
NEJAP_RS18060	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
NEJAP_RS18070	COG0583	DNA-binding transcription factor activity
NEJAP_RS18080	COG0179	Fumarylacetoacetate (FAA) hydrolase
NEJAP_RS18100	COG4181	ATPase activity
NEJAP_RS18115	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
NEJAP_RS18120	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
NEJAP_RS18135	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
NEJAP_RS18140	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
NEJAP_RS18145	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
NEJAP_RS18150	COG0840	transmembrane signaling receptor activity
NEJAP_RS18155	COG2204	response regulator
NEJAP_RS18165	COG0469	pyruvate kinase activity
NEJAP_RS18170	COG2183	response to ionizing radiation
NEJAP_RS18175	COG2918	glutathione biosynthetic process
NEJAP_RS18195	COG0545	Peptidyl-prolyl cis-trans isomerase
NEJAP_RS18205	COG0488	(ABC) transporter
NEJAP_RS18215	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NEJAP_RS18225	COG0194	GDP metabolic process
NEJAP_RS18230	COG4566	intracellular signal transduction
NEJAP_RS18235	COG4191	Histidine kinase
NEJAP_RS18240	COG0318	PFAM AMP-dependent synthetase and ligase
NEJAP_RS18250	COG2030	dehydratase
NEJAP_RS18260	COG1028	Short-chain dehydrogenase reductase Sdr
NEJAP_RS18265	COG5001	Diguanylate cyclase
NEJAP_RS18265	COG3300	MHYT domain
NEJAP_RS18275	COG0789	Transcriptional regulator
NEJAP_RS18285	COG2304	oxidoreductase activity
NEJAP_RS18290	COG2304	oxidoreductase activity
NEJAP_RS18305	COG0714	Associated with various cellular activities
NEJAP_RS18330	COG1476	TRANSCRIPTIONal
NEJAP_RS18365	COG4974	Belongs to the 'phage' integrase family
NEJAP_RS18395	COG0189	ligase activity
NEJAP_RS18395	COG4067	protein conserved in archaea
NEJAP_RS18405	COG0189	ligase activity
NEJAP_RS18460	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
NEJAP_RS18480	COG0582	viral genome integration into host DNA
NEJAP_RS18485	COG1561	YicC-like family, N-terminal region
NEJAP_RS18490	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
NEJAP_RS18495	COG0708	Exodeoxyribonuclease III
NEJAP_RS18500	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
NEJAP_RS18525	COG2165	general secretion pathway protein
NEJAP_RS18540	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
NEJAP_RS18550	COG3409	Peptidoglycan-binding domain 1 protein
NEJAP_RS18550	COG3267	Type II secretory pathway component ExeA
NEJAP_RS18585	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
NEJAP_RS18620	COG0739	heme binding
NEJAP_RS18630	COG0316	Belongs to the HesB IscA family
NEJAP_RS18635	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
NEJAP_RS18640	COG0038	chloride channel
NEJAP_RS18645	COG0352	thiamine-phosphate diphosphorylase activity
NEJAP_RS18650	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
NEJAP_RS18665	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NEJAP_RS18675	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
NEJAP_RS18680	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NEJAP_RS18685	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
NEJAP_RS18695	COG0436	Aminotransferase
NEJAP_RS18700	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
NEJAP_RS18725	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
NEJAP_RS18730	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
NEJAP_RS18750	COG2813	Specifically methylates the guanine in position
NEJAP_RS18760	COG1185	polyribonucleotide nucleotidyltransferase activity
NEJAP_RS18765	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
NEJAP_RS18770	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
NEJAP_RS18775	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
NEJAP_RS18780	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
NEJAP_RS18785	COG0195	Participates in both transcription termination and antitermination
NEJAP_RS18810	COG0149	triose-phosphate isomerase activity
NEJAP_RS18815	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NEJAP_RS18820	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
NEJAP_RS18830	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
NEJAP_RS18850	COG0505	Belongs to the CarA family
NEJAP_RS18875	COG0805	protein transport
NEJAP_RS18880	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NEJAP_RS18885	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NEJAP_RS18890	COG0140	phosphoribosyl-ATP diphosphatase activity
NEJAP_RS18895	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
NEJAP_RS18900	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
NEJAP_RS18920	COG0218	Necessary for normal cell division and for the maintenance of normal septation
NEJAP_RS18925	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NEJAP_RS18925	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NEJAP_RS18935	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
NEJAP_RS18940	COG0210	DNA helicase
NEJAP_RS18970	COG0573	inorganic phosphate transmembrane transporter activity
NEJAP_RS18975	COG0573	inorganic phosphate transmembrane transporter activity
NEJAP_RS18980	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
NEJAP_RS18990	COG4251	negative regulation of phosphorylation
NEJAP_RS18990	COG5001	Diguanylate cyclase
NEJAP_RS18990	COG3706	GGDEF domain
NEJAP_RS18990	COG2203	Gaf domain
NEJAP_RS19000	COG3161	chorismate lyase activity
NEJAP_RS19005	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
NEJAP_RS19020	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
NEJAP_RS19030	COG2130	NADP-dependent
NEJAP_RS19080	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
NEJAP_RS19085	COG1737	Transcriptional regulator
NEJAP_RS19095	COG0069	glutamate synthase activity
NEJAP_RS19105	COG2515	1-aminocyclopropane-1-carboxylate deaminase
NEJAP_RS19110	COG1126	abc transporter atp-binding protein
NEJAP_RS19115	COG0765	amino acid transport
NEJAP_RS19120	COG4597	amino acid ABC transporter
NEJAP_RS19125	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NEJAP_RS19130	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
NEJAP_RS19140	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
NEJAP_RS19145	COG1454	alcohol dehydrogenase
NEJAP_RS19155	COG1414	Transcriptional regulator
NEJAP_RS19160	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
NEJAP_RS19165	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
NEJAP_RS19175	COG0355	proton-transporting ATP synthase activity, rotational mechanism
NEJAP_RS19180	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
NEJAP_RS19185	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
NEJAP_RS19190	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
NEJAP_RS19195	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NEJAP_RS19200	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
NEJAP_RS19210	COG0356	it plays a direct role in the translocation of protons across the membrane
NEJAP_RS19220	COG1475	DNA binding
NEJAP_RS19225	COG1192	Involved in chromosome partitioning
NEJAP_RS19230	COG0357	Ribosomal RNA small subunit methyltransferase G
NEJAP_RS19235	COG0445	tRNA wobble uridine modification
NEJAP_RS19245	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NEJAP_RS19255	COG3845	ABC transporter
NEJAP_RS19260	COG4603	Belongs to the binding-protein-dependent transport system permease family
NEJAP_RS19265	COG1079	Belongs to the binding-protein-dependent transport system permease family
NEJAP_RS19275	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
NEJAP_RS19285	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
NEJAP_RS19300	COG0625	glutathione transferase activity
NEJAP_RS19305	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
NEJAP_RS19310	COG0706	membrane insertase activity
NEJAP_RS19315	COG0594	ribonuclease P activity
NEJAP_RS19320	COG0230	Belongs to the bacterial ribosomal protein bL34 family